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<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1B4</accession>
    <name>A0A132B1B4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_744072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947454">
        <property type="protein sequence ID" value="KUJ06168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1B4"/>
    <dbReference type="GeneID" id="28830744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744072"/>
    <dbReference type="InParanoid" id="A0A132B1B4"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24670" checksum="D1C397CED9D9CE25" modified="2016-05-11" version="1">MDSLQMQKAVRPRISYKIAVVHQSLVHFINNHSVYQPLLFPLDYLSWQSLQLLHITAHIGDITLMTSPGTRWQGLNSGGRFDGGSSGRRGGSGWSGGGGGGGAEGSRRTLCRNIQQGGRCRLSAGCTFSHDLSNSNSHESPLQPRERLADTPEQQHTREDYNSWKRLIKTPPKRNDIGTIELLWNSALTILNADDRDWKQMLPRNLDDKRIMAVNIFRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1W6</accession>
    <name>A0A132B1W6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_790591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060646.1">
        <property type="nucleotide sequence ID" value="XM_018223387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1W6"/>
    <dbReference type="GeneID" id="28833113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790591"/>
    <dbReference type="InParanoid" id="A0A132B1W6"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="257"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="47075" checksum="99C0E41BA363CA1F" modified="2016-05-11" version="1">MAPVSTLQNGLSQNGVSHETVSPDTDVNSVLSLANKVSELAVLQTHQVPVPQEEFLQAIQRLQIAVEGPAHYVARKRHEPNEYAATLLAIDSGVLEALVDNGRKPLSAQELAKKSKTDPLLITRFMRILTAIALFDEVDLDLYRSNEISEWLARPGQADGYRLIARWILPITSNVSSLWKTDRLFQFPDESKGEHNPFIETFKTTQWDMLRKDPDLKRAFDSYMPIRRNGLRVPWYEIYPAATELDIQGYSEQHEPPLLVDVGGNTGYESASFKAANPHIKGRAVVQDLAETLNSSVAPEGVERQVYDCFTPQPIKGARAYFMKALLHDFDDAESRRLLRHTVDAMGPESSLLIDDWVLPDTNAPVAGGTYDIMMWLLLSGMERSEGQWRALLESLGLEIKRIWRKEGVGEGVIEAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1Z1</accession>
    <name>A0A132B1Z1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_662331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060608.1">
        <property type="nucleotide sequence ID" value="XM_018212639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1Z1"/>
    <dbReference type="FunCoup" id="A0A132B1Z1">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B1Z1"/>
    <dbReference type="GeneID" id="28822365"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662331"/>
    <dbReference type="InParanoid" id="A0A132B1Z1"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008860">
        <property type="term" value="F:ferredoxin-NAD+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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            <position position="30"/>
        </location>
        <ligand>
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        </ligand>
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            <position position="38"/>
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        </ligand>
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        </ligand>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="194"/>
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        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        </ligand>
    </feature>
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            <position position="367"/>
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        </ligand>
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        <location>
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        </ligand>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ06253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="463" mass="50951" checksum="83E8C8957690EDA9" modified="2016-05-11" version="1">MAVIGSGPAGFYTAYKVMSKIENSVVDMYEHLPVPFGLVRFGVAPDHPEVKNCQDKFEEVAESPRFNFVGNISIGDDVGALPLRSLLPHYDAILFAYGASRDRTLGIPGEDTLKGIYSARAFVGWYNGLPEYSDLAPDLTLGEEAVVVGQGNVALDVTRILLQDTSVLKSTDITENAIETLQKSKVRRVRVVGRRGPMQAAFTIKEIRELMNLPSVEFEPVNGSLIPEDLKGLPRPSRRIMEVIKKGSKATEPTKKWSLDFCLSPKAFDASPTIHSQLGSVSFEKTTLNPDPFDPNARAIGTSQMVDISSSLAFRSIGYKSEPLAEFSELNIPFNDKSGTIPNDHLGRVVNEDGLVTPLKGMYCAGWVKRGPTGVIASTMADAFQTADSVAEDWHSHAAFLNSVDNEALGWDGVKQEAEKKGLRRVSWQDWKRIDAEERRRGSAQGKEREKFTKVEDMLAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B200</accession>
    <name>A0A132B200_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_412240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="381"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="635" mass="72169" checksum="3639D3D0177EE50B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Z6</accession>
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        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the CutC family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="267" mass="29383" checksum="AF24D3D8742FCC61" modified="2016-05-11" version="1">MHVIDPGLDFRFKLHNPANPTFPTTQLRSRDQVKIHLSTPLLVMPLLEIACFNIESGLIAQAAGADRIELCKNQQLGGTTPLLSDFQELKKHVEIPINVMIRPRGGDFTYDVNEIQQMGVELESFRDHGADGFVFGILGAGKVDIEKCRDLIEKAQGLPCTFHRAFDEIAEKDMLEQLNVLMECGFTSVLSSGGQKNAQEGIEVLKRLVETSKRRIDVIVGGGVRSTNLQEIERATGSGTFHSSAIVDGGEVTSKEEVEALKGIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4D3</accession>
    <name>A0A132B4D3_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4D3"/>
    <dbReference type="GeneID" id="28830658"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743202"/>
    <dbReference type="InParanoid" id="A0A132B4D3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="27893" checksum="1744A9D1AB2E0530" modified="2016-05-11" version="1">MDTNTQQNSLADVCSHPEAARDIESRDSTAPEIIVERTSPARSEGTPNYHGTHSVIEHQPANITSIHTPSESDEEPSATNVRKELKDSLAKVQLEMIRLNPTLFQKEDKSTKSLQAQLARLSAAIRAVDTVKQDTTEELKRQHKQDLEAKVSTLEKELEGKRKNAKALAEKHRADTLDLVQQVFDAGERILSREEALLEQDLRWMEAYEAKASRESEADKELEQRPDSSSLWMQEQATKDCSVIETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4M4</accession>
    <name>A0A132B4M4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_790240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061219.1">
        <property type="nucleotide sequence ID" value="XM_018223347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4M4"/>
    <dbReference type="STRING" id="149040.A0A132B4M4"/>
    <dbReference type="GeneID" id="28833073"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790240"/>
    <dbReference type="InParanoid" id="A0A132B4M4"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.30:FF:000006">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="284"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ06864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="377" mass="40366" checksum="53883B22C1EB74CE" modified="2016-05-11" version="1">MANNPLGTESILQHMADALPTHPQGDTGSDFSSSYEAIALFAHACMAAVGFRLVGFGEGQKMEAECTRLAPRLAPQWNSSFGSHSFLYAHSQSSMQYVVKIDRLGGKAEIRGIGLGDERISRFEVTAKDYVSSAALPLRITLNQSGEEDRSDLPSKLKDIFISPSRIQDLASLFKVTIIQKLMPGLHKEGYEEASNAGASAREDAEDERAEGHARRNPRQDPLRDPGLPEPARPYPFMPDVAQPRHPVPQGDFPPPGFDDEYDMNRPLRGMAPQFPGASSPFNIGHDDLNPPGLGPHDPLRGSFVGGGGLPRPGGMGGMHPTFDDPLFGGQGGVARQDPRAPPGARYDPLGPGDGPQRGGNGRPPNPFGGFGSGDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5G4</accession>
    <name>A0A132B5G4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_371883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061584.1">
        <property type="nucleotide sequence ID" value="XM_018207063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5G4"/>
    <dbReference type="GeneID" id="28816789"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_371883"/>
    <dbReference type="InParanoid" id="A0A132B5G4"/>
    <dbReference type="OrthoDB" id="4696326at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="49990" checksum="77F5C5C951E2D6E3" modified="2016-05-11" version="1">MANINYEEVYPTHISHLESPMYSHNASENQQNVPPEVVRDEVGLEHDPSQAQNFISDKGKFQELVASVPATPQYARDDKMAMAGEDAGPSEPRKYCGMSKKMMYAVSALVVIIVIVAVVGAVGGAVASKKSSKSTSVSPTSTSSATGVSATSSATPSATAASSAKLGAIAASNFQDDKSYLSVYYQTGSDIMYMIYPSSGSFSSLQNLTLSTTPKTGTPLAAVSVNGTSGAELSLYYLDTFNNIIEATFSSSLSSTTLTSNAITVIALNSTVSPLTSLAALYLDGYGYRAYYQNTTGYIYELVNGGSAWKAGSKLSALATSGSPLSASMVTVPHINIFYIGETVDELYNIAYDSSWLATKMVTSGTLTSWNSSISSLASAGQSDPNILRTYYIGSDEEIYEFGIESNSTWTTMTAAPDQSPHWSTSDSVGPGAIASLGWSDQMRLYYFHGGNLRQATLDNTTWSVQDLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5K4</accession>
    <name>A0A132B5K4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_601769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061529.1">
        <property type="nucleotide sequence ID" value="XM_018210212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5K4"/>
    <dbReference type="STRING" id="149040.A0A132B5K4"/>
    <dbReference type="GeneID" id="28819938"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601769"/>
    <dbReference type="InParanoid" id="A0A132B5K4"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="614" mass="67824" checksum="EB8948CA2639DE89" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B740</accession>
    <name>A0A132B740_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_691115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062581.1">
        <property type="nucleotide sequence ID" value="XM_018216236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B740"/>
    <dbReference type="GeneID" id="28825962"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691115"/>
    <dbReference type="InParanoid" id="A0A132B740"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287919" evidence="6">
        <location>
            <begin position="19"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="71"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="495"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="594" mass="62126" checksum="351C387395E68BAF" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B785</accession>
    <name>A0A132B785_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_725586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062214.1">
        <property type="nucleotide sequence ID" value="XM_018218988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B785"/>
    <dbReference type="GeneID" id="28828714"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725586"/>
    <dbReference type="InParanoid" id="A0A132B785"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="29414" checksum="44C453CF0116A507" modified="2016-05-11" version="1">MSLPLFTDPGILWVTSKITHPDHLSEQTYLNWYDNEHIPEVLSVTPIASLLRFRNLDPNAERPYLATCPLQDMADGGELRKVSVKSEKLPDDSGVLGGSSHDCADLDYRFYQLIQKYEPNGSEATLGKTKTIVTGGFDMGPEVSEQEFHDWYDKEHLELLSQLPGYLRTTRYKLLNHRTNAEARAIKGLPSRPNDTAIEKTEPPMFHAVHEFSIEELDNEAAMKTIGTERAKRIFSNATKSEYAVYRLEKSFGDGKFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B845</accession>
    <name>A0A132B845_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_725576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062202.1">
        <property type="nucleotide sequence ID" value="XM_018218985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B845"/>
    <dbReference type="STRING" id="149040.A0A132B845"/>
    <dbReference type="GeneID" id="28828711"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725576"/>
    <dbReference type="InParanoid" id="A0A132B845"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF19">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ07847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="494" mass="56423" checksum="CA519A3544705BDC" modified="2016-05-11" version="1">MAYYLQIAATLIAIYIQHGCKPAKRYPNWDPFLGLDAFVLFGIKAIQGKSSIEYRKLQLKYGPTFTMKRLTKASFIQTSSSKNIQAVNTTKFDDWSVGPSRQDIAIPFMENGIFTDDGESWKRARALVRPTFTRAEVADLEHFEKHLGRFLELIPKDGSMFDLQDLSRRLFLDTSSEFIFGQSIQSLLPQTPAETFEFMKAFDYSLLGLGLRLVSGPFLPLFFFDPTWKRAYTKVHRFMDKNIKIALERRRKIVETGEDTEAQGVRKPYILLNQMVLDTQDVFSLRAQIINIFFPARDTAAYAFSNAMFELARHPKVWDELRAEVSQIGDSKLTFELIKNLKVAKAIVNETLRLHIPATRLSRTALRDTILPVGGGPDQLSPLFVPKGTYIEMDINALHRDPKIWGGDALEFNPLRWAKGRTLWEARWEYLPFGGGIRMCPAQPMALAQVTYLLVRMAQEFKAVENRDHVSEYVEEIKMTVSSRNGVKISLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9I7</accession>
    <name>A0A132B9I7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_659411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062692.1">
        <property type="nucleotide sequence ID" value="XM_018212515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9I7"/>
    <dbReference type="GeneID" id="28822241"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659411"/>
    <dbReference type="InParanoid" id="A0A132B9I7"/>
    <dbReference type="OrthoDB" id="5270965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10551" checksum="A28DB5F80E9CD1BF" modified="2016-05-11" version="1">MAAKSQRASEQEVRSWGFPHVFTWTDGPNAYYSPHSHRGLTTHLILKGQLTITFPKGETPEKKTYTVGDRVDVEAGRVHEVWMGSEGCTYVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9W8</accession>
    <name>A0A132B9W8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_279324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063557.1">
        <property type="nucleotide sequence ID" value="XM_018206445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9W8"/>
    <dbReference type="GeneID" id="28816171"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_279324"/>
    <dbReference type="InParanoid" id="A0A132B9W8"/>
    <dbReference type="OrthoDB" id="10413807at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="23682" checksum="C21FB80E7CEDAEBB" modified="2016-05-11" version="1">MFELQECHYQQPRKRQPAKKSMGSASSKKFPESQSQPDDTRHSTADVLAEPPNDTHCWPVSASSSTGTFSSPLENRSGNNLQGLDSLSETQNFIRTWSENSPWGLPREVGNATSLTSAPPPTEMSSVPDSNVSLWPLFTTDAEWQLDFDDQLTTLPTSAVKGATPIAVNDLDLSQSYNQPIQDSESSGLSRGLIEYLNLIEKVSANATILVKRIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA38</accession>
    <name>A0A132BA38_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_325311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063089.1">
        <property type="nucleotide sequence ID" value="XM_018206740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA38"/>
    <dbReference type="GeneID" id="28816466"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_325311"/>
    <dbReference type="InParanoid" id="A0A132BA38"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="190" mass="21161" checksum="9EE540859A9DE374" modified="2016-05-11" version="1">MQQQMRGDLELLQLLLGQCVQYSTWYVGKAPQSPTLTQRHPSIHHQHQRGGSPHAGGLQARRELTLLYSAFSTGPRLLVGTRCALSTPAAFGRLYHRSQGPPGRWVRQGPQNNLLRICQGLGQQGGIRVLFSCCCCCCWACCTVLTGERGSVCEGGKGGVEEAISNWFYRRAMSCETERRGRVKRTQPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAH8</accession>
    <name>A0A132BAH8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_711209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063770.1">
        <property type="nucleotide sequence ID" value="XM_018217887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28827613"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711209"/>
    <dbReference type="InParanoid" id="A0A132BAH8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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                <person name="Kennedy M."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CBS 120377</strain>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09553.1"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBD6</accession>
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        <submittedName>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09706.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="55404" checksum="DAE2271C5E05A8C1" modified="2016-05-11" version="1">MSTSSARTSVSSTELTGAAKLEEVTRLMDKLASDLQHINLLPHQRDALLEQVKVYGRDPNNSDPIFTKEAGRGIETLTRHAFNSPSLTTSRNALRCLANALLLREKTRQIFVDLGYEQKACNKLKNDSRDDEFLVSRIIFLTTYGTKIDIEKLIDQYHLAENICLNISRHAKQFVTKQKKVRELDPMEDMALIETLKLMFNLTHFCPQRAAAFSPALQSLIIIMTKRAISSSKPLEPPIGPLVNSLLNIDLENKDNKSTLYPKATPTITVDRLIEILDKSIRAYQDEELEQNVSPLLTLLRKVYEIAPKEVQEHTQRALLPSAEDRKQILGRGTTLPSRLLRLSSNPTTPQVRESISSLLFELSGKDAKIFVQNVGYGFASGFLFQHNVPVPENALEAWSTSDSDSTHARASQDSKQGLLGKINPVTGQFLENETNVEMPEMTQDEKEREAEKLFVLFERLKKTGIMNVKNPVETALNEGRFLELEDDAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBF1</accession>
    <name>A0A132BBF1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_763445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063332.1">
        <property type="nucleotide sequence ID" value="XM_018221598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBF1"/>
    <dbReference type="STRING" id="149040.A0A132BBF1"/>
    <dbReference type="GeneID" id="28831324"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_763445"/>
    <dbReference type="InParanoid" id="A0A132BBF1"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Berberine/berberine-like" evidence="7">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="464" mass="51843" checksum="64F4E44C3709F348" modified="2016-05-11" version="1">MPLRNAKPSNVKVRRARKGVPTYELGDPEYEFVTHTANPLHRNRLPDCVVQPLTTVDVQYIVKQAKKKDIASTIKIGGHSYPGSSASDQGYIKLDLTNMNQPLVDGKHDGYVINGGRCPTVGVSGYILGGGICPFTRSFGMGCDTLLEATIVTADEIVHTVTRDDDPESSEGKLFWALCGAGQGSFGVVLELKMAVSKLKNKEGKVIAVRSTWFPKESDDVPAIKSAFYSAKWSTQMTIDTIWLCNTRDEAKIGVRFSAYYDGNGEDYLKEINQNIYNTSLKELFGERIVDRTSSDWLGNILPITWDEEAKRSKYVNQTFSIFGSFAFENRPSYGEKYKNGDGSSVEVSFIHPGTTAAKKPSTATAFPWRDVMQNLCRSIRAKLRPFSIFAEAAFVNFPNEATPKTAHESAYYGTNREKLREVKKMWDKNNFFGWDQGVGLPQPDLSIAAYIFKLKREIFVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD87</accession>
    <name>A0A132BD87_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_258589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064703.1">
        <property type="nucleotide sequence ID" value="XM_018206255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD87"/>
    <dbReference type="GeneID" id="28815981"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_258589"/>
    <dbReference type="InParanoid" id="A0A132BD87"/>
    <dbReference type="OrthoDB" id="3919855at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="20970" checksum="A517F4AC8316EF91" modified="2016-05-11" version="1">MEAFMKKGQNWKEDVQFMFAKPGQLNPRAAEEEQDGMSPKQVIASIAGDRKKAIDFWRALGFRRIANSEWFATAFDALHVVHQLAAEDDFDPREGVQLDVDDDQKALGALPSIEETPVTPPTSLREINLTLKDLGDHEPLSALSDEESDDDGDDDDFDEDDPFPWDPNRVTSEAKAYFQSRGIFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDD2</accession>
    <name>A0A132BDD2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_675121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064618.1">
        <property type="nucleotide sequence ID" value="XM_018213484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDD2"/>
    <dbReference type="STRING" id="149040.A0A132BDD2"/>
    <dbReference type="GeneID" id="28823210"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675121"/>
    <dbReference type="InParanoid" id="A0A132BDD2"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="816" mass="91719" checksum="B29BD81C9EC669DA" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDI8</accession>
    <name>A0A132BDI8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Saccharolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_656280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064845.1">
        <property type="nucleotide sequence ID" value="XM_018212375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDI8"/>
    <dbReference type="FunCoup" id="A0A132BDI8">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BDI8"/>
    <dbReference type="GeneID" id="28822101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656280"/>
    <dbReference type="InParanoid" id="A0A132BDI8"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="227"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="703" mass="80146" checksum="81862140A32A83F8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDL9</accession>
    <name>A0A132BDL9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_262682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064851.1">
        <property type="nucleotide sequence ID" value="XM_018206284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDL9"/>
    <dbReference type="FunCoup" id="A0A132BDL9">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="GeneID" id="28816010"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_262682"/>
    <dbReference type="InParanoid" id="A0A132BDL9"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="45732" checksum="2E53554E702F5EBC" modified="2016-05-11" version="1">MSSSPSKPLPQKTRRTHTKSRGGCMECKRRKLKCNEAKPVCGGCTKREITCVYPKVGSRTPLSKDAGQVLRPSTSLSVANALNGPATTSSPNVAVQEESSDAAAPARGIGQFDMKDMGLWHQFIYSTAATLSNPWGHELPGLALNCDYLLHGMLALGALHLAYLNPAKRESYSILASHHYDLAIGPFHRATKSVTPDNANQIFAFSTLLVVINYASDRSPELIFPFADGEAHDGLSNWMVDLRGCGIIFETASAHVIEQGPLGFLITQGKRLQEVLSTGAQPTPEDDRSLARIKDEVLNLTSVKTSTTVEEMEAYHDAIERLRALLAASTQPLDSVIKRAVCSIWPSRVSDTFVRLLSEKRPPAMIILAHYCLLLRGLEECWYMERRGVNLFQIVVGALDNEWAIYVDHPRREFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRF6</accession>
    <name>A0A194WRF6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_710424</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064948.1">
        <property type="nucleotide sequence ID" value="XM_018217827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRF6"/>
    <dbReference type="FunCoup" id="A0A194WRF6">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRF6"/>
    <dbReference type="GeneID" id="28827553"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710424"/>
    <dbReference type="InParanoid" id="A0A194WRF6"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
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    </dbReference>
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        <property type="term" value="P:aggrephagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitophagy"/>
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    </dbReference>
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        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C54"/>
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    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="98"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022927"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
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        </source>
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            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="433" mass="48336" checksum="2F70BB5CACE4446D" modified="2016-10-05" version="1">MAALDLGKYKKFVQYFYDPEPTNVLQSPIWCLGKEYRAPDRSSAAKDMHSSVPNVKSAPIGSSRVQPVTPPDSTASSIDSNLAYEDSENEQGGRWPSPFLDDFEARIWLTYRSNFPAIPKSQDPKAQAAMSLPVRIRSQFDKPAGFTSDTGWGCMIRSGQSLLANALVMVRLGRDWRRGSSTAEERKIISLFADSPNAPYSIHKFVEHGATACGKHPGEWFGPSATARCIQALTNDHESSELRVYLTGDGVEVYEDTFMKIARPDGVTFKPTLILVGTRLGLDKITPVYWEALKASLQMPQSIGIAGGQPSSSHYFIGVQGSFFFYLDPHQTRPALPLPANIEDYSQEDLDSCHTRRLRRIHVKEMDPSMLIAFLIRDENDWKDWRRAVQEVQGKAVIHVADREPALSTERDGAIDEVETFDDDDDDDTILDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSP5</accession>
    <name>A0A194WSP5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_567271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSP5"/>
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        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="GeneID" id="28818279"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_567271"/>
    <dbReference type="InParanoid" id="A0A194WSP5"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
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    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="594" mass="66051" checksum="7F9AF2F9742E751A" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSW7</accession>
    <name>A0A194WSW7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_235573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065403.1">
        <property type="nucleotide sequence ID" value="XM_018206058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSW7"/>
    <dbReference type="GeneID" id="28815784"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_235573"/>
    <dbReference type="InParanoid" id="A0A194WSW7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267470" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="10580" checksum="4023186CBA68ACFF" modified="2016-10-05" version="1">MIAWGMFPVQLPWLHVSFATEFDDSAGWVVFRACMQILTSSSVYNWDLKPTLARHAGLFLGIPGFREVGLAAYHHATMTVQYLRNAVSPSFHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSY2</accession>
    <name>A0A194WSY2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">White collar 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_655525</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065082.1">
        <property type="nucleotide sequence ID" value="XM_018212348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSY2"/>
    <dbReference type="STRING" id="149040.A0A194WSY2"/>
    <dbReference type="GeneID" id="28822074"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655525"/>
    <dbReference type="InParanoid" id="A0A194WSY2"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="523"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="862"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="900"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="907"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109939" checksum="2413E849A6EE1575" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV98</accession>
    <name>A0A194WV98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_654259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065944.1">
        <property type="nucleotide sequence ID" value="XM_018212291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV98"/>
    <dbReference type="GeneID" id="28822017"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654259"/>
    <dbReference type="InParanoid" id="A0A194WV98"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="471" mass="50154" checksum="7393662910CADF58" modified="2016-10-05" version="1">MASAQVEDETLQLATFLSQLAYEDLPQEVIERSKQAILNIIGCALGSANASPRRKALAALLPGAPAERGASGAVTIWGRPERTNLEDGAILNGIAATTADYDDTHLETVIHVACTAIAAILPFAEAHHLSGKEVILAFAVAVETQCAVALAVSPSSYADGWHITGLTGSFSGAAGIAKLLRLPPNQFAAALGHASSMASGTRAMFGTDTKTLHAGQHARNGITAAKMAKEGFASCVAPIEAWARLVSTTIDTSQIAALARGGPWQILRVSFKPYPCGIVIHPLIDACLEMYAFFSSANKTAEGPKRVEDIAKLEVVANPQLVRLCNVRHPRNGLETIFSLYHGCAVALVHGRAGVAEFSDATAAHDAQVYAVRDLITVRIDDKMRDDEAILHFRSRPSSGGAISEKTIRIERALGSVENPLSKAFLEEKFSRQAECSLDRKFADAIIKACWELDLVEDVSDIVKLLGATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVQ6</accession>
    <name>A0A194WVQ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_654533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066114.1">
        <property type="nucleotide sequence ID" value="XM_018212304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVQ6"/>
    <dbReference type="STRING" id="149040.A0A194WVQ6"/>
    <dbReference type="GeneID" id="28822030"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654533"/>
    <dbReference type="InParanoid" id="A0A194WVQ6"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="62177" checksum="673D84E038CD4A50" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWB7</accession>
    <name>A0A194WWB7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_203927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066621.1">
        <property type="nucleotide sequence ID" value="XM_018205804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWB7"/>
    <dbReference type="GeneID" id="28815530"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_203927"/>
    <dbReference type="InParanoid" id="A0A194WWB7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="258" mass="28847" checksum="B3DB4CB9D6317EEB" modified="2016-10-05" version="1">MSSPNSWQSNLYGDRAPSRTGPSAGPESSPYNSSPGPGWGERDRYTNPRENIPYGADRGGRGPYRSPYFSSAIPYGADTGYSNRRPSPPPYRAPVADMGYGGESGRFSSDTPYRAPVADMVYSRSTSRRPSKPDLPYRAPVADMGYGSDRPQYSSDIPYRAPVAEMGYSRRSITPPSTPSLPYRAPVADMGYGTFGPYSVSPSRPRANTNADPYRSPGAYPQYLDRDPLDIRERDTRSRSPDQYRRRYYDDGPRRREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWI1</accession>
    <name>A0A194WWI1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_688511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066394.1">
        <property type="nucleotide sequence ID" value="XM_018215723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWI1"/>
    <dbReference type="GeneID" id="28825449"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688511"/>
    <dbReference type="InParanoid" id="A0A194WWI1"/>
    <dbReference type="OrthoDB" id="10455913at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="17675" checksum="2B30280EAF0AA9D1" modified="2016-10-05" version="1">MASMSTMSLPMPFSGEPFPCRIGLTRKDGDNIQNGANEIFMISPAALDTRRGLVDQVKTHFHSLEKRPQSDRVNVPDRCFWGADYDAERVKVTWDPVNTYGASSWAPGTSMNETEITDANLKTMLHALKLSPPSTCVMSLLITHSVPLDLVSRGHANHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWI7</accession>
    <name>A0A194WWI7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_688056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066665.1">
        <property type="nucleotide sequence ID" value="XM_018215629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWI7"/>
    <dbReference type="FunCoup" id="A0A194WWI7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWI7"/>
    <dbReference type="GeneID" id="28825355"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688056"/>
    <dbReference type="InParanoid" id="A0A194WWI7"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="46883" checksum="6363285B3D67630F" modified="2016-10-05" version="1">MFSSKKPYSAVTVAVENLTSEHYEEDDVGGIPDLVEAIKLQASGPAEAARAIRKKLKYGNVHRQIRALVILDGLIQNAGARFQRTFADEMLLERLRVCGTSDLSDPLVRDKCKELFRNWAVEYKNVRGLEQVAGLYKQLPRRKQVVTQDQSKVLRETAENPFEDDEEEVVAPPPQPRHASVASSPAQSSRSSPPPSFFSSISSSTDTKKSKKEKDKKKKKGKPFNLESEKETMKNCIAESSVASTNLLNALRLINREREQISENKNAVHHFEFCKLLRRKILRYIQLVESEQWLGALLHANDELVTALMTFEQLDRSIDADSDSDDELAHQQHLYKTMSDKGKENAAANQFAGLSLGTKSPSPPRPPRQPPRPAPQPEPEEEDDFEEEDENDPFADRNALQTPKVEKKEPVWRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWM4</accession>
    <name>A0A194WWM4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1761-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066337.1">
        <property type="nucleotide sequence ID" value="XM_018215710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWM4"/>
    <dbReference type="GeneID" id="28825436"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688466"/>
    <dbReference type="InParanoid" id="A0A194WWM4"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="15670" checksum="8C0E35C933D94FCC" modified="2016-10-05" version="1">MSLHYLPPVKPSAIALGTIFNHAASLAVLGPVFGDTYHRAQAANSKEEFVKSKEAASAAAAWGTSLVGSAVQSYGVGALINATGTLSYKGAAYLGGLIFMASSAPSFIAQIFTEKRPLDTVAVGAVARVFETVGLSLFLTWWGTRTNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX21</accession>
    <name>A0A194WX21_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_592955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066883.1">
        <property type="nucleotide sequence ID" value="XM_018209724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX21"/>
    <dbReference type="GeneID" id="28819450"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592955"/>
    <dbReference type="InParanoid" id="A0A194WX21"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="48273" checksum="EAB298B7BA36D261" modified="2016-10-05" version="1">MAAPVNSGYLQTNDPTKPRSDAAVPFRDIIPAPTHPRIAGIVDHDALSWCESRRQIEAPAWLINRLEKKNLERPYKGFTSDGKVREGLYEYAEDEGAPTEEAIAKTEALMKILSEEQKKAVHCGDVTDDEFRLWSNPELYMNPGGLRLDECSSEIQTAIHAILKASSSKQGYEKILGCCLTNDFLGHLVNGKKILNEHSYNFRLFGTPSLNSPWGYTFFGHHLCLNVVFLGKRMVIGPTFMGAEPDRIDEGPHAGLRLFRTEELESLKLMQGLPKELQEKATLSKGMDGNSLPADRWNPFDERHLAGARQDNRIVPFEGCPVSEFPADKQESIINLFLAFNEYYPESVLQHRLALFKKHLPETYFAWIGEFGDEDPYYYRIHSPVGFMELDFHCGIFLTNTTPARCHIHTTNRLPNRGDYGRALIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXF6</accession>
    <name>A0A194WXF6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_652664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066622.1">
        <property type="nucleotide sequence ID" value="XM_018212210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXF6"/>
    <dbReference type="GeneID" id="28821936"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652664"/>
    <dbReference type="InParanoid" id="A0A194WXF6"/>
    <dbReference type="OrthoDB" id="3528649at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16667" checksum="04A362ED7A66491D" modified="2016-10-05" version="1">MVQECLQPVFEQHKLSKYGFLLKQITHPLATSKQHYFKTAWVFADTRSPLWAEVNDVFFNPHAKPIDDDRVGVALGYPEVSRSFAGESKFSAVDLTEMGELEVEMGRRVCSVRAFDFRCGSEHFGNLVPYFERCAAAAKEVGTVLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0I9</accession>
    <name>A0A194X0I9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_687518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067737.1">
        <property type="nucleotide sequence ID" value="XM_018215516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0I9"/>
    <dbReference type="GeneID" id="28825242"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687518"/>
    <dbReference type="InParanoid" id="A0A194X0I9"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="489" mass="54789" checksum="6D76861F8C0EC38A" modified="2016-10-05" version="1">MSSQVCSRCRKRKIRCDLQLPACRNCRLADAECLFWEEALGKEIPCSYVHSLQQRVASLQLEIKNATDKAPATSTSLRGRDNLISAHAPEQGYHSNVVGYNDVPSPSRTSYLGPGSSARLLERLTKSAVQWHSVNNIQLPKNLLPDEASVMIRSQQLQGLWPVDMTHDQRAELHSLVPPSTQRAIIENYLDKVSPEYSLFSDEADSKLLAYENPLRWSSSNPTSPSAFAIAIVFAISTALISRDLDSNLAAISKRFREKVQIISQRTASSGDRIETAKETCAALCALAICELINPVSNQLWDLLGRAVSTMEHLREGYRLRGLSLDREFLELELSLLKLESFATLHFRRPSQFCEMRLKTIIGNLDGHKQLLEELNILPYLHAIAQKLRDVPDPSERLLEELVPLPLRIYSTTSDISIALATVYTALHPLFTASETFWNRIFDDALPGLLQLIAYSSLTIIDHVGRLNANNKVLSVWMTAERVLEFGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X146</accession>
    <name>A0A194X146_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_149627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068270.1">
        <property type="nucleotide sequence ID" value="XM_018205388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X146"/>
    <dbReference type="GeneID" id="28815114"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_149627"/>
    <dbReference type="InParanoid" id="A0A194X146"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="88" mass="9870" checksum="3BF3EDA05BFCFDB4" modified="2016-10-05" version="1">MTASPIQKRTSHPLLPSWETFNQSLLVPSEHWSLSLIIDVQIWITIQSLLSLSDVRTLWLGAVFVVVSTFAQALPRSLPIFNVGLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1T8</accession>
    <name>A0A194X1T8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_589743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068523.1">
        <property type="nucleotide sequence ID" value="XM_018209552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1T8"/>
    <dbReference type="GeneID" id="28819278"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589743"/>
    <dbReference type="InParanoid" id="A0A194X1T8"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="37498" checksum="12C67B938272491B" modified="2016-10-05" version="1">MAVHRPSEAGPSSSSHPSENHHEDRTNTPPPYSGPTTPSMTAPSAPQPQPNYPGLPRLDYSLYSPKGFTISSDATTLTSKEQRLSVNPVALVSLIKSLATVPPKPQIRITGRTSDSGSIDFDVKINLMNLIVPDEDKRGRMNYVKIIGPGDVGFRGEGKETTFPHVNGLEAWAQKYCEDPASIKRFTLERTVINWDTSYLEGRLLSLISSTSYRGHVTITFPMTHSRVVVHSPDEVNNFFSSVNMFFSSITKGHTGTKKYEVVKSIWPYADVARGEYGRRCAVQEEEVWFADWRDAIRHAILSKRRGWVTAEDRLEFLMVPKPGKLGPQPAGWGGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1U4</accession>
    <name>A0A194X1U4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_708629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068528.1">
        <property type="nucleotide sequence ID" value="XM_018217692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1U4"/>
    <dbReference type="GeneID" id="28827418"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708629"/>
    <dbReference type="InParanoid" id="A0A194X1U4"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="50879" checksum="4D83A15D926946B0" modified="2016-10-05" version="1">MDIDERIELMHEVQGKLWEDRLNETQRSGRLCAWVSSFHHDRLPCWLGDNDFRYGSYNAGFKLVFGDGTAWLLRFPRVGRVHDAYADEKVAMEVAVINLIRNETTVPVPKIHAWGVAAQNSLGLGPFIIMEFIRDALLRENLNDDEIEIIYRQFANFLLQLLKLDFEQIGSLDSPTPGLRFPIRPLTWKAHDILQTGGVDIFGDRNRGFSSTTEYFQYLAEQDWEQLFWQPNSSLIPKFVHKEYDRGKFKIVCDDLGLANLIVRSRQDLTVIGVVDFEWSYIGPAQLFGSAPWWLLMDRPTNKAWDCDMGEPIRITNRYFRYLNIFKHVLGEEEDKTPGHENKELSNLIHWSEESGAMWVHMLLSTGFNDPCSFPFTKLLQHIGVDEWDRREKEVSQEEAAAFGAQKALQLEQYNCDLETEAHKALVDEGRKDDFIPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2P4</accession>
    <name>A0A194X2P4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_709066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068462.1">
        <property type="nucleotide sequence ID" value="XM_018217730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2P4"/>
    <dbReference type="GeneID" id="28827456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709066"/>
    <dbReference type="InParanoid" id="A0A194X2P4"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="255" mass="27119" checksum="357E4B7FE427D01B" modified="2016-10-05" version="1">MPPILKHHVLIVGGTSGIGFAVAELALASGCTVAIASSNPTRISSAIIRLQASFLDKKSLISGHEIDLQTPDIEARLTTLFDAVTSNKSKLLNHIVFTAGRIPKLKPLPEMDIISTLNLTQSSLSAPLALGKLAPPYLVPSYSSSITLTGGRVADKPLPNYTLFSFYASGLHGLVKSLAFDLAPIRVNMASPGATVTEMWGPEEVREMMAKKVGETALLGKVGSAEEVAEGYVYFMRDWNVTGEVLRSEGGAILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2V0</accession>
    <name>A0A194X2V0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_589726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068863.1">
        <property type="nucleotide sequence ID" value="XM_018209550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2V0"/>
    <dbReference type="STRING" id="149040.A0A194X2V0"/>
    <dbReference type="GeneID" id="28819276"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589726"/>
    <dbReference type="InParanoid" id="A0A194X2V0"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="39551" checksum="B3DFC702862CCA24" modified="2016-10-05" version="1">MEEIPITGLEELEKHLDILLEAPDTPLDAKLFDEVELQLNDPNIPPLIPRLLPKLTQILLTYTEDPTLLASLSTKLLRPIKFTQALTLASEDALISALRSPAPAAAILAITVIEKATRSPGDTAILSIMKGVVESFLRTWLSTPHVGVGEKATKTLGDLLEVDCDRRNSADIDTKMSGLQIASGMPPGQGLLWRRIFQDRGIYDLIFSLCSFTTMGSGEGQLDERQKSLAQARLLRVLPRLAVLDFQTITRSHFPDIEARYGIREQGLLYFACAEMVDKEEDLLMHITLIDFFVEFLDMMSNTAITKTTMDYLAVLMKKVAGSDSTLYKSLESLALSPDTSPELVDLLVKLNEYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2X5</accession>
    <name>A0A194X2X5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_142355</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
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            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
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        <property type="nucleotide sequence ID" value="XM_018205324.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ENDOCHITINASE A"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="23"/>
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        <location>
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        <location>
            <begin position="518"/>
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            <end position="513"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="811"/>
            <end position="860"/>
        </location>
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        </location>
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            <begin position="916"/>
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        </location>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
    <sequence length="1132" mass="114647" checksum="2739C68360F2FA20" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X422</accession>
    <name>A0A194X422_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="86"/>
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        </location>
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            <end position="111"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="120" mass="13587" checksum="17FDB7E1D9DAC365" modified="2016-10-05" version="1">MSLSRADRNFRFLFVNTLFREISASTIPSHNMKSNVHRLSDRQTLIEDTQDAAANSSGMNETGKIVLLVFGPLAGLMILWAAYYVCIGDMIKKWRAEKKGTREKDKKDKMTGIELPNHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4H8</accession>
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        <name evidence="4" type="ORF">LY89DRAFT_686627</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="37216" checksum="B056FE080486B58C" modified="2016-10-05" version="1">MAPPTSNNAAILRVRHGQHQIVTRATPSILSDEVLIQITATAINPVDWKLRDDFGDMLTYPAVLGSDAAGNIAAVGDEVTTLSVGDRVFFQGIIGNSDASTFQQYCKMPAVLVGKTPSRISDEQAGATSLSSMAAATALYSDTGFAIQPPWTEGGEQSGQGKAIIILGGSSSVGQYAIQLARISGFQRIITNSSKSHFAALQRLGATEVLDRSSATPADYAAATHGLEATHVLDAISIETTTLLAIDILQQLKGGDVVTLLPKMQQPIKPPHPDPQRPVHTKRVVGLGSLPENRHISEPLMNALGGDDGWLAKGIFVPINVEIVTGGLAALEMALAKNKKGVSGVKIVIRPHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4R6</accession>
    <name>A0A194X4R6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_589052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4R6"/>
    <dbReference type="GeneID" id="28819236"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589052"/>
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    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11530)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14161" checksum="A61F05D159A44910" modified="2016-10-05" version="1">MAHPLLSNPFSKDTSNNIVNGSCLCGAITFTLTGAPSTTVLCHCLSCKKSSGSAFQANGFYENSQLTLSPDSTAAMKTYTDKSCDSSGTVDRVFCSTCGSRLFNRNPKYKDALIVNSGVLDLGDEGWREWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X508</accession>
    <name>A0A194X508_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_124374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X508"/>
    <dbReference type="GeneID" id="28814909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_124374"/>
    <dbReference type="InParanoid" id="A0A194X508"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="59" mass="6591" checksum="9AE5281EF41324A8" modified="2016-10-05" version="1">MVCIARLDGCHCTDWVGFWVYSISSASSWFWSLSGINTGIRTIYLDVQAVLSDISYVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5M7</accession>
    <name>A0A194X5M7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_783619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069838.1">
        <property type="nucleotide sequence ID" value="XM_018222700.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28832426"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783619"/>
    <dbReference type="InParanoid" id="A0A194X5M7"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1376" mass="155175" checksum="C8DB7E3623FB3D95" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7D0</accession>
    <name>A0A194X7D0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070433.1">
        <property type="nucleotide sequence ID" value="XM_018222664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7D0"/>
    <dbReference type="GeneID" id="28832390"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783298"/>
    <dbReference type="InParanoid" id="A0A194X7D0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267981" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="159" mass="16514" checksum="ABADF44DEE45E093" modified="2016-10-05" version="1">MPSYLFKMIIILLILVPLIPAARDSGRTALKPSNFGVLNYQGTLQGIDVDLNGTIESKTQCCTGSSTAPSPAAILKAINWLLGVPGDCWAPANSCVQLSCTSDSAIVLCNTNSNSVDPSCPSLGSLAQDVYSSCTNGAGICGSQVDSNCYEITNERGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7G3</accession>
    <name>A0A194X7G3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_697823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Labutti K."/>
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        </source>
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                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
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    <dbReference type="InParanoid" id="A0A194X8K7"/>
    <dbReference type="OrthoDB" id="3523141at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="430" mass="47566" checksum="B9A3DBA07BBCB07D" modified="2016-10-05" version="1">MISYDIEPQPHAILPTQSVPRNLLTANTFFKEITSTFLCPTTTSEQYLFWNYYHRLDTMDSHQNTSTRGAKHKTAIDEEIVTPPSNKSNTTGQASGQGSSVNAAITGTTRSDSRRKVGKRSGVEDSNQATKKARTIKGVRREVDRDSEELDLPIAGVTGTNSSLHYTNYSYMFPGQPRPQAQRNPSFQITIPSGDHKELDGRHPPIIFPNANCGAAIRSPSAIWEAARTVLTQQARQLGGSDAAEASKQKLWDNIAVYRDNVWLGNLNDIRLAFQFSLNESFYKTQLDFKRIRTRKLSSKSQEAGFYLVNSSGLYLKVSDNKVAELNKDLLIDLGKDLNDELATLTMDGHKTVMVDLRTMNTDGLPIPDGCPIVKDVLAKGPQAFPTEFTRTLAGCCGWTNGHAHMGIAALCSVKKGDPKPELGVFEYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X929</accession>
    <name>A0A194X929_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_62824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071031.1">
        <property type="nucleotide sequence ID" value="XM_018211180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X929"/>
    <dbReference type="GeneID" id="28820906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_62824"/>
    <dbReference type="InParanoid" id="A0A194X929"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF5">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE CMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33050" checksum="B5AC2C10FE90ABA9" modified="2016-10-05" version="1">MNFLGPEKCTLSIVEGHSTDGTFEILKLLRSTIEQLGASYSFVSSGLDSKVGGRIEILAKFRNLALEPLMGSSNLDKTTVVFLNDVAICSEDILELIHQRVQQKADMTCAMDWTYVGNDPTFYDVWIARGMTGDSFFDIPEDGNWDSAWNLFWNDPMAQSRLNNRQPIQVFSCWNGAVVFAGEVLKKIKFRRSGEVECYQGEPKLFCKDMWYHGYGKIAVVPSVSIIYSDDDMRKIKALIGFTSDWTDKEREGQQIEWNENPPELVKCMRNYQDQTWVPWNESLPLKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X960</accession>
    <name>A0A194X960_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_747835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071058.1">
        <property type="nucleotide sequence ID" value="XM_018221140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X960"/>
    <dbReference type="STRING" id="149040.A0A194X960"/>
    <dbReference type="GeneID" id="28830866"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_747835"/>
    <dbReference type="InParanoid" id="A0A194X960"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="36629" checksum="721739C241F6E4E8" modified="2016-10-05" version="1">MAATWTDMCPPSPQFTEANMSDQFGRVFLVTGGTSGIGYETAKTLYHLNGTIYITSRSESSALKAVESIKSSLPHSSQVIKPGRGSISYLQLNPSDLRSIKSSANELLKKEKRLDVIIHNADVMLPADPKQKTEQGYHQLGINVLAPFILQHYLTPLLLSTASLLDAKAFSTRVIWVSSSGHRASPAPDGVAWDNVNLEGTDKKAMNVMLAYEFARRFQDNGNRILSLSLHPGALKTGLQGNLPRWFYAIFGRLRYETRMGALTECWAAIREIDIGNGEAGLLGNKTRGENGGYVVPWGRWGEGHEGVMNGLIEKGTGERLWGLLEAILMEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9H0</accession>
    <name>A0A194X9H0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_585042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071173.1">
        <property type="nucleotide sequence ID" value="XM_018209304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9H0"/>
    <dbReference type="GeneID" id="28819030"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585042"/>
    <dbReference type="InParanoid" id="A0A194X9H0"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="586" mass="65662" checksum="E15EADE67C554C34" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAN7</accession>
    <name>A0A194XAN7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_645778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071177.1">
        <property type="nucleotide sequence ID" value="XM_018211894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAN7"/>
    <dbReference type="STRING" id="149040.A0A194XAN7"/>
    <dbReference type="GeneID" id="28821620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645778"/>
    <dbReference type="InParanoid" id="A0A194XAN7"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268071" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="359" mass="37871" checksum="696AB26BA9FE8155" modified="2016-10-05" version="1">MLRSVFLLNSLGLALGGTILWDGRFNDMTSSTELDNWSWSDETGPYQYYIHGTENVTSYVNLDSTFKNPVDTGSTQGVKVTLDSTSYWDGQTMRRTELIPQTSAAINKGTVYYHFSMQRTDTNAPSEFREHQICFFESHFTEMKAGWISGESGTSDALLRWDVSSATQWNTTWEAGVWHNIAYAIDFDAGSVAFYHSTGADDLVLTVPAVTVSASSNGADWHLGVLELPRDGYTDATEDIYFSGVYVESSDLTTSVSGPGNTSASGVASSVSVASMSAPASSSVVGSASTVSSAPASTSSTAATVASSSSAPSGVTVSSSADTASVSSTLTPSTTLSTVIVPPTSTSTPTDPDDDDDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBF7</accession>
    <name>A0A194XBF7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_781698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071856.1">
        <property type="nucleotide sequence ID" value="XM_018222507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBF7"/>
    <dbReference type="STRING" id="149040.A0A194XBF7"/>
    <dbReference type="GeneID" id="28832233"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781698"/>
    <dbReference type="InParanoid" id="A0A194XBF7"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="85"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="413" mass="46515" checksum="F082A600A034E20E" modified="2016-10-05" version="1">MECAVEGEDYRSRLKEFQDVEARRLQFIEEMLSKLDTVTADLERVTQDRAREVSILKADLETEREARRGLQEKNGNLLLSVSKMEQARFVLVLVDADADIYLFRDGLLAQGGQGGQFAAEELIAKVREYLATFESFKDAAKIPIMVKAYANFSGLAQACMRDKKVVSMEAMMEFWCGFTRRFPLVDFINVGPGKEEADSKLREVLAHHIVSPLCEHVLLACCHDAGYVPVLRQYAAQKDFSSRITLIASGPFRGDMVSLGLRTTKSFEPLFGHVKSSQSVRSYAEVGAVAPRPPSTSKAVLSVQDLKLSGKPVANCDRLRPILFNEAGKRIDKPLSVHGDCVKEIRKRNLCSWHYLRADCIVDGCKKVHDFRRPLTPKNYDALWCISRENVCRRLSKHGKCEDDQCIFGHGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBJ6</accession>
    <name>A0A194XBJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071889.1">
        <property type="nucleotide sequence ID" value="XM_018214906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBJ6"/>
    <dbReference type="GeneID" id="28824632"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684554"/>
    <dbReference type="InParanoid" id="A0A194XBJ6"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="222" mass="25396" checksum="BBF6BC3BA7048F55" modified="2016-10-05" version="1">MDLTHALLIGDDPYFDASSWQEFGDCEPWWGRVPKNDDFLEIMAILSQLATLGHEVRNFRSTAPIGVLFAIQTALDQQAARQEEVDKTKEQAGWTAFCACYRFSASVYLYRALSVLDVDHELVQKSVADCMEVISGHDLTDKLHHCILFPVLIIGTHCLDSKQRVEIRKSLARTASYLSFEALRSLESFLEKRWHELDTSPELKEAGWWVYFDEIANVTCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBQ4</accession>
    <name>A0A194XBQ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_57986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071950.1">
        <property type="nucleotide sequence ID" value="XM_018209033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBQ4"/>
    <dbReference type="GeneID" id="28818759"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_57986"/>
    <dbReference type="InParanoid" id="A0A194XBQ4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="772" mass="85194" checksum="58492AD331CE6AC4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC63</accession>
    <name>A0A194XC63_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duf1857 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_733196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071697.1">
        <property type="nucleotide sequence ID" value="XM_018219773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC63"/>
    <dbReference type="STRING" id="149040.A0A194XC63"/>
    <dbReference type="GeneID" id="28829499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733196"/>
    <dbReference type="InParanoid" id="A0A194XC63"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08863">
        <property type="entry name" value="SRPBCC_DUF1857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="164" mass="17962" checksum="3636D11B7DEC1008" modified="2016-10-05" version="1">MVVIHLAYTTIVNPPGAQSILSHAQVWAGLERKARVPQEFVPVVETCEIHSEKDNVITATVIFKADSAVAHARTIREVCTLSPPCRLDYDMEDGSTATNIISMGKGSTGDNELFLTFIFAWEHPQLVQGSDEAKEAEDQHKTIAAAAVYSTLQTIRNLVEKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCN2</accession>
    <name>A0A194XCN2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_683902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072271.1">
        <property type="nucleotide sequence ID" value="XM_018214775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCN2"/>
    <dbReference type="GeneID" id="28824501"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683902"/>
    <dbReference type="InParanoid" id="A0A194XCN2"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="32166" checksum="F58D262947541E5B" modified="2016-10-05" version="1">MARTKVALAGATGNLGAVVLKALLNANHHVTVLSRINGNSSRLTPHPNIAIAKVDFNSTHSLTTALQGVEVVISCLATLAIGSQNLLIDASVSAGIKRFIPAEFGMDSLNPLCTKLPVCVPKVDTQRYLQEKTLSYPGFSYTGIANGLFLDWGLKVGFILNMAAHSATLYNGGDVPFSATILVDIAKAVLGVIDNQDETANRIIYVHSVVTTQNKLLEYAKEKDGEGWHTVFKDTEDIRRESLAELANGDIGAAMDGFCICAMWSSDYGCDFSSHLDNDLVGVKMMEEDKLKELVGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD04</accession>
    <name>A0A194XD04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_36187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072408.1">
        <property type="nucleotide sequence ID" value="XM_018207002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD04"/>
    <dbReference type="STRING" id="149040.A0A194XD04"/>
    <dbReference type="GeneID" id="28816728"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_36187"/>
    <dbReference type="InParanoid" id="A0A194XD04"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="801" mass="85117" checksum="82E2B13A59B20168" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD69</accession>
    <name>A0A194XD69_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_732810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072473.1">
        <property type="nucleotide sequence ID" value="XM_018219735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD69"/>
    <dbReference type="FunCoup" id="A0A194XD69">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD69"/>
    <dbReference type="GeneID" id="28829461"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732810"/>
    <dbReference type="InParanoid" id="A0A194XD69"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ18118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12025" checksum="8F9D1A34EE7C8BE1" modified="2016-10-05" version="1">MPFKDGDAKKGANLFKTRCAQCHTLGEGEGNKIGPNLHGLFGRHTGSVPGFSYTDANKAKGIEWNTDTLFEYLENPKKYIPGTKMAFGGLKKDKDRNDLITFLREETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD80</accession>
    <name>A0A194XD80_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_37933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072469.1">
        <property type="nucleotide sequence ID" value="XM_018207119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD80"/>
    <dbReference type="FunCoup" id="A0A194XD80">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD80"/>
    <dbReference type="GeneID" id="28816845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_37933"/>
    <dbReference type="InParanoid" id="A0A194XD80"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16996" checksum="4106107E83BD1938" modified="2016-10-05" version="1">MGSVVLPHLVTGWHVDQAIMSEDERLVIIRFGRDWDPDCMRQDEVLYRIADRVKNFAVIYVCDLDQVPDFKQMYELYDPLTLMFFFRNKHMMCDFGTGNNNKLNWVLEDKQELIDIIETIYRGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE17</accession>
    <name>A0A194XE17_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_684331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072780.1">
        <property type="nucleotide sequence ID" value="XM_018214858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE17"/>
    <dbReference type="FunCoup" id="A0A194XE17">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XE17"/>
    <dbReference type="GeneID" id="28824584"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684331"/>
    <dbReference type="InParanoid" id="A0A194XE17"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="71" mass="8038" checksum="B647FE592B8F0528" modified="2016-10-05" version="1">MPRAIRGVLIECDPSIKSIIVQIDAEDHAYIVEELDDQTLVVKENMLTSLKMKLDEKLKATQIPVEESDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE57</accession>
    <name>A0A194XE57_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_496766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072818.1">
        <property type="nucleotide sequence ID" value="XM_018207932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE57"/>
    <dbReference type="ESTHER" id="9helo-a0a194xe57">
        <property type="family name" value="Glucuronoyl_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="28817658"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_496766"/>
    <dbReference type="InParanoid" id="A0A194XE57"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268175" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="99"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="394" mass="40678" checksum="A75777BD92B0501A" modified="2016-10-05" version="1">MKYLSSILLLAIPALAAPSPTITERQDAGCGIASGFSYQTDAKLPDPFTSTNGTKITTKAQWPCRAEEISQLFQKYELGTLPPKPSSVTATYSAGSIKVTVSDGGKSITFSAKITTPSSGKAPYPAIIGIGGVSIPSQAGVASITFDNDGMAAQASKSSHGTGLFFNLYGSSATAGATTAWAWGVSRLIDALEMTPTANIDTTKLGVSGCSRNGKGAFIAGALEPRIALTIPQESGSGGAACWRISDAQKAAGKNIQTAGEIVGENAWFSPNFNAYSTKTSDLPVDHHMLAGLIVPRGLFVIENDIDWLGPVSTTGCQQVGQMIYKAMGVPENFGFSLVGGHSHCAFPSAQASDLSAAVSKFLLGGTGSATEVSKSSVTVDPTTYIDWTAPVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFC4</accession>
    <name>A0A194XFC4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_613966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073189.1">
        <property type="nucleotide sequence ID" value="XM_018210675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFC4"/>
    <dbReference type="GeneID" id="28820401"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613966"/>
    <dbReference type="InParanoid" id="A0A194XFC4"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="58"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="45800" checksum="509F777070B56947" modified="2016-10-05" version="1">MPDTFNDTMSQDFLVQDKLALNAAENTIPGAVCWAIDSTGNPVLPPDTLGHRSILPDAQPMSKDTVFFLASTTKLVTAVAAMQCVERGLISLDDPVGKHLPEIDNAKVIEGWRQDENGKEEPILRQATSQVTLRQLLCHTSGVSASIFDPVYRKYNDWKGWPQRNPTTPELMAHPLRFDPGTKWIYGFGIDWAGILVGRLNNCTLGEYFQTNIFDPLKLTSTTLRPTKHPKIQDRLASITVRDKLGQLQPEPFNIWLKDSEEVEMDSGGYGLFSTAEDYISFLHTFILDDNPLLSKESMDEMFKPQLPSSEWLKANAVDSKGIVISGNIMFPESPVNHGLGFILAEEDLPTGCTAWAAEGGGLTNTFWWIDRKAGIAGVVFLNMLPYMDTEAVQLWKKFQAKTYSKLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFR6</accession>
    <name>A0A194XFR6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Bud site selection protein BUD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_773108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073395.1">
        <property type="nucleotide sequence ID" value="XM_018221924.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFR6"/>
    <dbReference type="GeneID" id="28831650"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773108"/>
    <dbReference type="InParanoid" id="A0A194XFR6"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13278">
        <property type="entry name" value="PH_Bud4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000311">
        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1275"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="941"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="315"/>
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        </location>
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        </location>
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            <begin position="546"/>
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        </location>
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            <begin position="556"/>
            <end position="565"/>
        </location>
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            <begin position="1428"/>
            <end position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19040.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1441" mass="160115" checksum="ACA478EB0BE1E3DE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG29</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28832138"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="332"/>
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        </location>
    </feature>
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            <begin position="350"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="369" mass="40987" checksum="0CCE2F2AD997A026" modified="2016-10-05" version="1">MAHNYILQVTAGSSYDIKHHQIVPVNQPTPITITSPHLIASLNVRIAQYRGLPPTSPATSPYFTQHPKDQYSISFAFTLNEDVNGDDLVFGNDFDHPIRDRLPPGFGTAFKIVKWVVDPGLDGDVYADKPYLYGAAGSSVNALWVGGKSDEKGEKEGEDGGEEKVWEEGGSEEGMEVRHEKGVPDSEAGRKKWFLGEENRKSWTWEQGRCYGVDFFNPYLDFNGISLSHSFPCPLPSRNPEIKKGKNTDFALRLPGFTLPIMKYWDGQGLRYVLKNRKTDEVLLVVLFTLYLKEDVGEDGVVKDGVEGGKPIALLGEGERERHRRAIFGTDGEGEESSGEEEEEDERSDGDEGKEKKVEVGGNGDDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHD0</accession>
    <name>A0A194XHD0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207911.1"/>
    </dbReference>
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        <property type="interactions" value="726"/>
    </dbReference>
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    <dbReference type="GeneID" id="28817637"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_493340"/>
    <dbReference type="InParanoid" id="A0A194XHD0"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
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    </dbReference>
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        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="624"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ19534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="899" mass="99290" checksum="8E54ACD0BBE2885F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHQ4</accession>
    <name>A0A194XHQ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074100.1">
        <property type="nucleotide sequence ID" value="XM_018222316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHQ4"/>
    <dbReference type="GeneID" id="28832042"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779656"/>
    <dbReference type="InParanoid" id="A0A194XHQ4"/>
    <dbReference type="OrthoDB" id="3445164at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18291" checksum="320AEC86AE25B6A5" modified="2016-10-05" version="1">MASTSKSKSSGGTTLNEISKIETQIAVEAQEVQLKANEVSESVSTAGPATLVTLPPEILLLIFDYLNPAASTCLGLTCKKLYPVHRAIHGIVRLSAPSEPNGFYLWYLLKDFFPGLIFCEDWEMFTTDQTLEDLWMRPHTIPLSRWPHWMLQYRGRTLSVAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHT2</accession>
    <name>A0A194XHT2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_581157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073687.1">
        <property type="nucleotide sequence ID" value="XM_018209099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHT2"/>
    <dbReference type="GeneID" id="28818825"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581157"/>
    <dbReference type="InParanoid" id="A0A194XHT2"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="525" mass="59513" checksum="AA71D2B83E7166D0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI08</accession>
    <name>A0A194XI08_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_666703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074210.1">
        <property type="nucleotide sequence ID" value="XM_018212930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI08"/>
    <dbReference type="FunCoup" id="A0A194XI08">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XI08"/>
    <dbReference type="GeneID" id="28822656"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666703"/>
    <dbReference type="InParanoid" id="A0A194XI08"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="819" mass="91489" checksum="89FEE7199E4D0433" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIN4</accession>
    <name>A0A194XIN4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_457059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073982.1">
        <property type="nucleotide sequence ID" value="XM_018207646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIN4"/>
    <dbReference type="GeneID" id="28817372"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_457059"/>
    <dbReference type="InParanoid" id="A0A194XIN4"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08994">
        <property type="entry name" value="GH43_62_32_68_117_130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268294" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="395" mass="43372" checksum="E9239190E80AF996" modified="2016-10-05" version="1">MKILLLLSSTFTFLHTISSSSSNTTFICKTDHDCRLNGLCSLTTSTCICDPGWTSPTCGALDLLPATLGTGYNKTSFNASSWGSKIIHDPSNSLLFHLFLAGFTHQCGLDYWSPYSRIVHATSLEGPAGPYEFHSEVVGTFAHNPTVIWSPADEKWLLYYIGCPQSVNATCTSPSFSCGPGNFINGESGISVLSSEDLYSWTPHGQVMSGMNDGAWDADITNPSPHPLGRKGEMLLVYRGCPFNCSGNELISLSTAPSFLGPYTKLSSPIFPESNEDPFVWQDKRGNWHMLLHSLEPDGGFGSGPMVGRHAFAEKLEGEWTFDAETLAFSAVVEFQGGEVREFYRRERPQLFFSEDAEMKPLFLMTGVQEVGSEMSYSLIQPIEGAREWEQALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIP6</accession>
    <name>A0A194XIP6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_580632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073992.1">
        <property type="nucleotide sequence ID" value="XM_018209069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIP6"/>
    <dbReference type="FunCoup" id="A0A194XIP6">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIP6"/>
    <dbReference type="GeneID" id="28818795"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_580632"/>
    <dbReference type="InParanoid" id="A0A194XIP6"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="120" mass="13253" checksum="EC937D701EB03768" modified="2016-10-05" version="1">MPDSAQINRSLSTIRTELEFLQASNVLSPPQFQSIMAQLPQQNGQPSNYIDLRYNPNPQQQFNPGAMAQQAQDPAHPANPQNPKHHEWVKNMASKFGNAAMFGAGATFGGDMVNDVLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ11</accession>
    <name>A0A194XJ11_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_555432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074464.1">
        <property type="nucleotide sequence ID" value="XM_018208360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ11"/>
    <dbReference type="GeneID" id="28818086"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_555432"/>
    <dbReference type="InParanoid" id="A0A194XJ11"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="28163" checksum="123C385D8329C40F" modified="2016-10-05" version="1" fragment="single">MKQNVLVIIGAGGLGLAAARRLGSGRHTLLASYSARTISFAQQSLQDEGYSVSSIHVDISSYDSVKKVADAASALGHIDAIILTSGVTPVSANAKQIYEVDFLGHANVIDAFLPIVSLGTSVMCIASMAPYFAAALSTPLSQELEKHLATAPLNKLLQYPEIDLSDGNEGAGTAYMNAKRGNQIRVEAAAKAYGLKGARINSVSPGVIMTKQGKLELEGRHGPAMKGLIENSALGRAATPEQIVNVIAFLVSQESSFITGVDILADGGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ41</accession>
    <name>A0A194XJ41_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_682930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074499.1">
        <property type="nucleotide sequence ID" value="XM_018214604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ41"/>
    <dbReference type="GeneID" id="28824330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682930"/>
    <dbReference type="InParanoid" id="A0A194XJ41"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="524" mass="59077" checksum="4219CA53C042F0B1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJB3</accession>
    <name>A0A194XJB3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214545.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XJB3"/>
    <dbReference type="GeneID" id="28824271"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682685"/>
    <dbReference type="InParanoid" id="A0A194XJB3"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="17983" checksum="FD9D0304BA95EC48" modified="2016-10-05" version="1">MTPAVASGEQYFKIGDFVTFGWNYTSLEATPTAVNILASCSANSQVYTISMNQTLANNTGAVTWDTGNYQATAVQNPLLTETYTLIIYDAASSISATAQAGYLAVYDSYTFGMYTPQPYTPLADFQCATCNGALGDMEKKALGMMFGMCCLTVLSFTWFVSGTGIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJD1</accession>
    <name>A0A194XJD1_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_771123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJD1"/>
    <dbReference type="STRING" id="149040.A0A194XJD1"/>
    <dbReference type="GeneID" id="28831602"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_771123"/>
    <dbReference type="InParanoid" id="A0A194XJD1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="24320" checksum="142B281A5FB86E4F" modified="2016-10-05" version="1">MTTGKPASEGLPSLLTIRIEKASEGLNAGHFTSVDLVKACIARIEEASNFNAVLQVNPDVLIAAKSLDDKRLRSGSRGPLHGIPILLDASAGTYALLGAKPAVESSLISRLRKTGVIILGKTNLSEWANFRGLNISASWSPRGDQTLGAYCPNTRSDGSSSGSAVATALGLCGAALGTEVKSAVLFRREMKRNLTQIQTIGSIVDPAEIANVVGFKPTRGLIGTDGAIPISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJG7</accession>
    <name>A0A194XJG7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_772535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074257.1">
        <property type="nucleotide sequence ID" value="XM_018221910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJG7"/>
    <dbReference type="GeneID" id="28831636"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_772535"/>
    <dbReference type="InParanoid" id="A0A194XJG7"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="20974" checksum="881A6E46D5F575AA" modified="2016-10-05" version="1">MTFQLQDIDPEKDFKELIECEWVSYEEPQQTFFRLFCPIIGQGPNSRVESLKESTDCQLKWHFRSYELLAKGCRWQLREDRWSGEDHSEAYWFPAGGQRDFVAQALHQFDAPRAEMAQRPQIYLNIIYTHPEYRRKGIADMVMDWGIKKADEMGVEMWLDATIYSLPFYEKHGFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJR5</accession>
    <name>A0A194XJR5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_639877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074731.1">
        <property type="nucleotide sequence ID" value="XM_018211640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJR5"/>
    <dbReference type="FunCoup" id="A0A194XJR5">
        <property type="interactions" value="1191"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJR5"/>
    <dbReference type="GeneID" id="28821366"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639877"/>
    <dbReference type="InParanoid" id="A0A194XJR5"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="207" mass="22990" checksum="C5DE3F9D47C42A71" modified="2016-10-05" version="1">MSAVLEATRPAAQTKTFGKSTREVPHHSQKAKKWYPAEDEAQPKKVRKSIRVSTPRPSLVPGTVLILLAGRFRGKRVILLKNLDQGVLLVTGPFKINGVPLRRVNARYVIATSHKVDLAGVDSKKVEEVGSEKYFAAEKGEKKKGEEAFFKQGEKAEKKKPSSSRAADQKAVDKALLATIKKEPMLISYLASTFSLRKGDRPHEMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKE3</accession>
    <name>A0A194XKE3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_730642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074966.1">
        <property type="nucleotide sequence ID" value="XM_018219498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKE3"/>
    <dbReference type="FunCoup" id="A0A194XKE3">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKE3"/>
    <dbReference type="GeneID" id="28829224"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730642"/>
    <dbReference type="InParanoid" id="A0A194XKE3"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25529" checksum="98671C783B9FD274" modified="2016-10-05" version="1">MSSTGTGWAQLRQQARSLETQTETLFHTYSQFSSVPNIPAKPSEDEKQTEAKIQDLLEKRETLIAQLSRLLDSEAQLTASALKQNNLARHREILQEHRKELSRLKSQIQDARNRVNLLSNVRNDIDAYHSSNPEAAEADYMLDERSRIDNSHNMADSVLSQAYAVNESFGLQRETLMSINRRITGAAAQVPGLNSLIGRISAKKRRDGIIFGSFIAFCLLAFIYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKP7</accession>
    <name>A0A194XKP7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_579308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075088.1">
        <property type="nucleotide sequence ID" value="XM_018208996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKP7"/>
    <dbReference type="STRING" id="149040.A0A194XKP7"/>
    <dbReference type="GeneID" id="28818722"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579308"/>
    <dbReference type="InParanoid" id="A0A194XKP7"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="405" mass="42420" checksum="0AB434D2A08098B6" modified="2016-10-05" version="1">MSANTVHVKNISSQTSEKEIRDFFSFCGKITSLEVSKSEPTQDATVTFEKETAAKTALLLDNTQLGATQVQVSSATGSSEDDGSHYKSQSERESDEITQEEKPRSRIIAEYLAHGYVVGDQAIQRAIELDQKHGVSNRFVQTLTSLDSKYHATDKAKSVDNTYGVSSRANTFLTGLTSYYEKATDTPTGKKLVNFYTQASRQVQDIHNEARRLADLKKQDSGVSKVPGSEKTTCKCNSNCEECPCAPGQCACVGCAKSDVKEAAGTKKTTCNCGGDTGKCGCAPGNCACSSCPKSDTEKVAGTEKTTCNCGGDTAKCACAPGACACKSCPKADTEKVAGSDKTTCKCGGNTEKCGCAPGACACSSCPKAKTEKVAGTDKTTCNCGGDEKNCPCEAGKCACGGCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLX7</accession>
    <name>A0A194XLX7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein-like protein oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_609490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075444.1">
        <property type="nucleotide sequence ID" value="XM_018210520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLX7"/>
    <dbReference type="GeneID" id="28820246"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_609490"/>
    <dbReference type="InParanoid" id="A0A194XLX7"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="123"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="37233" checksum="F31C0FE035B16AE0" modified="2016-10-05" version="1">MPLTNRTSLLQVFHRPAQKYKPLHPHLTLLQLRNFTPTFKMGQREDAEKQIKRNPHPDFKKVEGSRQPWDKSLEWNMKQTVKPDWKYGDGANDGGASLKIPHVEIDPYEEGRPAVSNYKLLISGIIPRPIGFLSTRSKDGTSTNLAPFSYFQVINHDPPLFTVGYAGGFDNAKDSLKNLVESGECVINIISEHFIEAANSTSVNAPYGESEWTLSGLTPAPSKTVKASRVKEAVFSIEGKLDFTKEYESKATPGKKTGVLAVIEGTRFWVREDALNEEKNLIDPAVLRAMSRLGGITYARVLEGMELLRPDWQESVVNNEEAKKIVKPKADGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMC0</accession>
    <name>A0A194XMC0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_665394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075272.1">
        <property type="nucleotide sequence ID" value="XM_018212839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMC0"/>
    <dbReference type="FunCoup" id="A0A194XMC0">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XMC0"/>
    <dbReference type="GeneID" id="28822565"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665394"/>
    <dbReference type="InParanoid" id="A0A194XMC0"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="285" mass="31254" checksum="797C0F41F8C4B7EB" modified="2016-10-05" version="1">MSLKTTATIASFGGKLLKLTHDATTTGCEMALNLYLPPNAGATQQKVPVLFYLSGLTCTGDNCAEKGFFQYGASQKGIAIVYPDTSPRGLKIQGEDDSYDFGSGAGFYIDATADPWSKNYKMESYITSELPKALFSSFPELDSSRVSITGHSMGGHGALTLFLKNPGMYKSVSALAPIANPSNCPWGEKAFKGYLGDDKESWKKHDATELIKKWKSSFDTLIDVGTGDNFYKQKQLLPENFLEAAKQSGNDKGIVLRMQPDYDHSYYFISTFATDHVNHAAKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMM1</accession>
    <name>A0A194XMM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075860.1">
        <property type="nucleotide sequence ID" value="XM_018214415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMM1"/>
    <dbReference type="GeneID" id="28824141"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681993"/>
    <dbReference type="InParanoid" id="A0A194XMM1"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="54"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="694" mass="78080" checksum="51441EA80C24C40E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMZ5</accession>
    <name>A0A194XMZ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_705053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075502.1">
        <property type="nucleotide sequence ID" value="XM_018217423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMZ5"/>
    <dbReference type="STRING" id="149040.A0A194XMZ5"/>
    <dbReference type="GeneID" id="28827149"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705053"/>
    <dbReference type="InParanoid" id="A0A194XMZ5"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="173"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ21147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="578" mass="64390" checksum="F62E14C839322986" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN43</accession>
    <name>A0A194XN43_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_681047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075938.1">
        <property type="nucleotide sequence ID" value="XM_018214196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN43"/>
    <dbReference type="GeneID" id="28823922"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681047"/>
    <dbReference type="InParanoid" id="A0A194XN43"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="290" mass="33445" checksum="96367172F594978A" modified="2016-10-05" version="1">MATQAPAVQPPKPKRKRRSTAIQPSITDFEYFPKLPYELRSMIWKIPCFVPRDVDIWMRSEGEVRLTEIPERTPGERFLPNSYHTKSVPPIILQVNQESRREGLRWYRLEFGINMKCGGVQYILPPKIYINWSVDLLCVKDSNCISTTSLYSDTSFSKLCRDNRLKTLALNVKNFKYWGPIKANSFGIPLRKMSLSELIFFDDASSTSKANYRFEAFQKTKRNGTLSKVIQAPGVLLEVSTARDMIITSWDTYEADLEEKKKNGVEGLVTLPPRPTITLMRFITPRPRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ22</accession>
    <name>A0A194XQ22_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_638376</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076509.1">
        <property type="nucleotide sequence ID" value="XM_018211572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ22"/>
    <dbReference type="FunCoup" id="A0A194XQ22">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQ22"/>
    <dbReference type="GeneID" id="28821298"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_638376"/>
    <dbReference type="InParanoid" id="A0A194XQ22"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="433"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="726"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="928"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ22154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="995" mass="113569" checksum="779190E254D2841B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQK0</accession>
    <name>A0A194XQK0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076796.1">
        <property type="nucleotide sequence ID" value="XM_018214108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQK0"/>
    <dbReference type="GeneID" id="28823834"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680588"/>
    <dbReference type="InParanoid" id="A0A194XQK0"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00583">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="24697" checksum="A7090F19E1C83C79" modified="2016-10-05" version="1">MSSYTYKIHHLPTSDATLLPFLAGKFASLRLSALTVSATAFSSTFEIESAFTSSQWINRLKRPLVHTFVAVAYGAGTPPEQQTIDAGDWIGSATLLGPFPKEMYELKESGGPVIGNDEVETRWQMTAVYNSPAHRGKGIAKMLISGASEYAALQSGQGRSTRIRIMIHPNNVVVKKLYYDLGFVDAGSTTLAEAYFSNGDTDLLPPDGGASDPGKYHLRAGLIMEKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRG8</accession>
    <name>A0A194XRG8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_574896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077240.1">
        <property type="nucleotide sequence ID" value="XM_018208773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRG8"/>
    <dbReference type="GeneID" id="28818499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574896"/>
    <dbReference type="InParanoid" id="A0A194XRG8"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="440" mass="49310" checksum="79ACE7F33CA5C338" modified="2016-10-05" version="1">MNTGDLHVPNVDFKIPNVDINIDGYFVGPRAMEKHSKWPTFMRLHGSITPRMLLPMFIITLWSIIVTGQEEANIIAVGVSSILLTVLGFVVGLSLSFRGSTAYERYMEGRKCWTALTVQSRNLARYIWVHVLEREGDQGKEDLMAKITAINLIHALAVSVKHQLRFEPYTFYPDMVSLVGHLDTFAKAAEHPGLQNPKHPISRWKEIGECLGLNMATSNPRKAIKRSIKPVGNLPYEVMLDLSAYFEMVINNGTLSSTIIYGQVLNAMAAVTDTIATANRVLATPLPIGYATLISQVVVLYIYILPFQLFPSFGWNTIPATMVAAYIILGLEAMGNELEIPFGNNVNDLPLNNFCDEIRRDLDVVMSSYRADGSFVDLMKRSERVNKVLWPLSNSPQGDWKRRSKEEIRSALKAKVVVGETRRLSAERQSEERAVVMLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRQ3</accession>
    <name>A0A194XRQ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_703664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077325.1">
        <property type="nucleotide sequence ID" value="XM_018217337.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XRQ3">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRQ3"/>
    <dbReference type="GeneID" id="28827063"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703664"/>
    <dbReference type="InParanoid" id="A0A194XRQ3"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
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            <end position="215"/>
        </location>
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            <end position="365"/>
        </location>
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            <end position="464"/>
        </location>
    </feature>
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        <location>
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            <end position="712"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="817"/>
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        </location>
    </feature>
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        <location>
            <begin position="984"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1291" mass="142331" checksum="9BEFEDE5F6841CF6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS02</accession>
    <name>A0A194XS02_MOLSC</name>
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            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">LY89DRAFT_607663</name>
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the FAH family.</text>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="289" mass="31336" checksum="EF502B671F0A5256" modified="2016-10-05" version="1">MSSFSRLVRFLAKDGRTYYGDAILPHGVTDIAKAKQAKIIKGQIFGKHDVTDQVADIRLLLAPLALEDVNTVRCLGLNYEQHAKESNMPIPKYPVLFYKPITSIAGPTDPIPIHPLAQQGTGLDYECELVAIIGKPCADVPESKALDYVLGYSVGNDVSHRDWQIKHGGGQWALGKGFDGWAPFGPGIVSSKLISDPQNLQIWTKLNGKVMQESSTKDMIFGVAKTIAFLSQGTTLLPGDMIFTGTPQGVGMGRKPQVWLKDGDVVEVGLEGVGTCTNQVEFIKAKSKL</sequence>
</entry>
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    <reference evidence="2 3" key="1">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="28816353"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_310345"/>
    <dbReference type="InParanoid" id="A0A194XSR1"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24155" checksum="FBAC1622EC7AFEC0" modified="2016-10-05" version="1">MPKALAIGSRKKRLSLLSSKPSILKNARDSFEWGINELTAPRLKKSEKPQRKARFSMYSGNTTPEEMPPTPPPKSPRRKKKSFATGEHPLKSPYPFAGKEEDDTIMSPSENRFGSKISGAIKSLSTGGRRGSLTNNNNKIVITNKARKNSGPDTPVVGKSSFVETINRGNEQLQGIIEKTRKSVLRTAEEKRRDELKKKIVVVGIGDQSPDGRVSEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSY7</accession>
    <name>A0A194XSY7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28815312"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_177280"/>
    <dbReference type="InParanoid" id="A0A194XSY7"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268563" evidence="2">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13527" checksum="65E27129B9240E43" modified="2016-10-05" version="1">MRVAALVMPLLQLSALFPQERRGTRDQGESWAQPKRASSQNRAEQGGRLGTTPGPPRSGRRITTKIYYYYHPSSYDPSHHTLHLAAGPARSGQVSKTSKRRPVAKQRPPALLESRPRRACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTB3</accession>
    <name>A0A194XTB3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_680065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_680065"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
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        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CuRO_3_MCO_like_4"/>
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        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_C"/>
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        <property type="entry name" value="ADR239WP"/>
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
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            <begin position="28"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ23289.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="69936" checksum="F4887A8B555B0F19" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUC8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <end position="21"/>
        </location>
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        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="22128" checksum="AB367842F9A0D1DC" modified="2016-10-05" version="1">MNTINPIENGHFTGTPRNPEVDYLSRSPLPTLKTQYRQFKQELVRVEANERHLRRQHALDQDPYCPDLGPERTFQPLKDKVLFLRQAIELRLEQTKNGQYFWTPKEYVLRFESGDMNYAHLADPIARYRLQRAFAEVHRDRIPPSQEMIEEVARQINNASLNFPMTYRPYTQARESAGRTIYSQNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUE8</accession>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">LY89DRAFT_635596</name>
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            <taxon>Mollisia</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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            <end position="271"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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            <end position="860"/>
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            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="486"/>
            <end position="697"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="869" mass="97703" checksum="7845563ECF02616B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVR6</accession>
    <name>A0A194XVR6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_3376</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078162.1">
        <property type="nucleotide sequence ID" value="XM_018206832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVR6"/>
    <dbReference type="GeneID" id="28816558"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_3376"/>
    <dbReference type="InParanoid" id="A0A194XVR6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="191" mass="22663" checksum="F1B09550375602AB" modified="2016-10-05" version="1">MEAFATRMKDPALHTRKRQLRWHHLAQRWGNDIRVGVAWSNHLLFQNLWDHPQYFVPKRAVQIPNDHKNLWYQVKILFSVFTLQTETHNVGALDASDECDSTRGPRVLASATFAFRLDDRQFRSTWSDLRWRKAALMVGHFIRSSRPWAQARLDPGRRSASAKQLRKLDLLCQRWRQRPFCLPRKVCEHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWA3</accession>
    <name>A0A194XWA3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-coumarate-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_8812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078357.1">
        <property type="nucleotide sequence ID" value="XM_018223483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWA3"/>
    <dbReference type="STRING" id="149040.A0A194XWA3"/>
    <dbReference type="GeneID" id="28833209"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_8812"/>
    <dbReference type="InParanoid" id="A0A194XWA3"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="445"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="547" mass="61117" checksum="7CFAC110E97E0EE8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1T6</accession>
    <name>A0A132B1T6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="13">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_678889</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="13"/>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060695.1">
        <property type="nucleotide sequence ID" value="XM_018213776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1T6"/>
    <dbReference type="STRING" id="149040.A0A132B1T6"/>
    <dbReference type="GeneID" id="28823502"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678889"/>
    <dbReference type="InParanoid" id="A0A132B1T6"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287757" description="xylan 1,4-beta-xylosidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="15">
        <location>
            <begin position="93"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="16">
        <location>
            <begin position="354"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ06340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="692" mass="74355" checksum="11EEB781FE4FFC15" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B255</accession>
    <name>A0A132B255_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_662269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060678.1">
        <property type="nucleotide sequence ID" value="XM_018212638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B255"/>
    <dbReference type="STRING" id="149040.A0A132B255"/>
    <dbReference type="GeneID" id="28822364"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662269"/>
    <dbReference type="InParanoid" id="A0A132B255"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="35"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="39474" checksum="5F4F9CD97D59794A" modified="2016-05-11" version="1">MAQHQCHNVFKGPDSMVQYFNPDLQPFLPLVEIPDKLNPFRSSNVRIYAKMLTALPAQNVKMLPGKQSIHVKASPSGSTALSLGMVSRVLWGNEDVCAYVTNKKHPDQLRTLRFFGLRVSLYGGLAQQEPDDANGIMCRLRNLATNDETISYPGQYDNDDASSLESHERWTGPQIWQQLPDINIFCTTVGTGAGCITGTGKHLKSQKQAVKVVGICNVFGDPTPGPRHYPKFESCKFPWRENIDAFETVASVESYEMSMQLSREGLICGPSFGEALVGLLRYLKKLEATGRLEELKGETSGDISCVFVCCDLPYQYMDGYFQKIQDDKFPPILNEVRSALVILVLIRTDNKDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B333</accession>
    <name>A0A132B333_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_726501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060804.1">
        <property type="nucleotide sequence ID" value="XM_018219058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B333"/>
    <dbReference type="GeneID" id="28828784"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726501"/>
    <dbReference type="InParanoid" id="A0A132B333"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="62085" checksum="53EB117F35E219A5" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B364</accession>
    <name>A0A132B364_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_703032</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 10"/>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060709.1">
        <property type="nucleotide sequence ID" value="XM_018217287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B364"/>
    <dbReference type="FunCoup" id="A0A132B364">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B364"/>
    <dbReference type="GeneID" id="28827013"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703032"/>
    <dbReference type="InParanoid" id="A0A132B364"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="11">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="12">
        <location>
            <begin position="261"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ06354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="45653" checksum="E575F2A5CAF850ED" modified="2016-05-11" version="1">MGSHPSDSIAYVRRTMHRHADVVVVGAGVFGTAMAITLARQSRSVFLLERSLKEPDRIVGELLQPGGVRALEKLGLQQCLDEIDAIPVKGYEVLYHSRSVSIPYPTDHSADPGRASKRLRAAAAAEPNITIVETEVDGIIKAEQSSQVLGVKSVTNSARDYFFASLTIVADGYKSKFRAESASRKPVSKSKFWALELRGVTLPSPCFGHTRALINVPDGLPSAKPSVGGVSHYIRQDLMLYLPAEIQLSFSKSLDNQRLRFGDAMNMRHPLTGGGMTIALNDVVLLQDLLHPSKVLDLEATSLQKKNLTSVINILAQALYALFSAEDRYMEALRKGCFEYFNRGGACIDGPARLLAGIVPKPIILIYHFFSVAVFSIWVFLSSQPGWRLPLTLLECGIILFKACQVLFPCIAAELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3P6</accession>
    <name>A0A132B3P6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">LY89DRAFT_602190</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061306.1">
        <property type="nucleotide sequence ID" value="XM_018210234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3P6"/>
    <dbReference type="FunCoup" id="A0A132B3P6">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B3P6"/>
    <dbReference type="GeneID" id="28819960"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602190"/>
    <dbReference type="InParanoid" id="A0A132B3P6"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="273"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="466"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="483"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="611"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="617"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KUJ06951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="692" mass="76642" checksum="5CA06A89C9895661" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4K9</accession>
    <name>A0A132B4K9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_742909</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061616.1">
        <property type="nucleotide sequence ID" value="XM_018220894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4K9"/>
    <dbReference type="STRING" id="149040.A0A132B4K9"/>
    <dbReference type="GeneID" id="28830620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742909"/>
    <dbReference type="InParanoid" id="A0A132B4K9"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ran binding protein zinc finger-like"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="241"/>
            <end position="274"/>
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    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="308"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="571"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="13">
        <location>
            <begin position="672"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="562"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="676"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="545"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="562"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="636"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="83043" checksum="630C7A100A9BE4D0" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B566</accession>
    <name>A0A132B566_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_691588</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018216367.1"/>
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        <property type="interactions" value="603"/>
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    <dbReference type="OrthoDB" id="16262at2759"/>
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        <property type="reaction ID" value="UER00055"/>
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    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005948">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:L-valine biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acetolactate_synth_lsu"/>
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    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
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        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
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        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="98"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="296"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="506"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="700" mass="76067" checksum="B2AAEB4F52589C2A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5K1</accession>
    <name>A0A132B5K1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="5" type="ORF">LY89DRAFT_540973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061624.1">
        <property type="nucleotide sequence ID" value="XM_018208174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5K1"/>
    <dbReference type="GeneID" id="28817900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_540973"/>
    <dbReference type="InParanoid" id="A0A132B5K1"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="17880" checksum="A9F882371CF9044A" modified="2016-05-11" version="1" fragment="single">MAEPQPERTRTSQTSSASDVQSAFFSQRARRQLGLFAAGAGFFAIASVITRRSLVRRYKQSIPKFFQPSNRLNYEVNGAMEALEALNLATINVISVGMMATGGLLWAFDISSLDDMRKKVRTNLGVDPIRTDEDAEQEIEEWFATVLARKEFKALRAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5X2</accession>
    <name>A0A132B5X2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062163.1">
        <property type="nucleotide sequence ID" value="XM_018216341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5X2"/>
    <dbReference type="GeneID" id="28826067"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691505"/>
    <dbReference type="InParanoid" id="A0A132B5X2"/>
    <dbReference type="OrthoDB" id="3562627at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="58150" checksum="DE4B47F5CF18BE71" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B627</accession>
    <name>A0A132B627_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061699.1">
        <property type="nucleotide sequence ID" value="XM_018216411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B627"/>
    <dbReference type="STRING" id="149040.A0A132B627"/>
    <dbReference type="GeneID" id="28826137"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691807"/>
    <dbReference type="InParanoid" id="A0A132B627"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="284" mass="29081" checksum="48DF2746CFF68347" modified="2016-05-11" version="1">MIGQPANTLGEFPISVSISSTLQQTCVANSGAVAGVSCFAICPTQGLVPLDTAVRPFQLNQTTPPSGPLNTVSQVFFNKDSTMLLATVKGDPTKNNTGFLSMFPVTNGSVSRNEIRTSPTGTAVLFGTALLPDADQIFVTDASFGSATLSLPSNSSNLNLATVSSSTKIADQKATCWATFSSLTSTTFVTDVAVNHLVEVDPSSGQLITEFQSQNGNGGMIDLESDQEGGLIFALSPGGGEVGAQGTNVVVFDVSGGKGSVTEMQNFAVQMGVAGGSAQGMAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B662</accession>
    <name>A0A132B662_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_601023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062098.1">
        <property type="nucleotide sequence ID" value="XM_018210178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B662"/>
    <dbReference type="GeneID" id="28819904"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601023"/>
    <dbReference type="InParanoid" id="A0A132B662"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="2">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="22317" checksum="A7738C09A6059B82" modified="2016-05-11" version="1">MVGLDGYCPRWAPGSVIRWAAWRQGFKTDEDAMYAANHLNIAAEKWNSLDIGVTFEWVPLAKDATFVLCHGGSNGTTLAQAFFPGPEDLSYLLVFNAAFSLKGWKENMWKIFTHELGHVLGLRHEFAMDINPKTGEVHERQTAVKLGPRNESSVMTYGRKPPEIQQSDIDSTKAFYALVDDAEGNPPKIGLAEVRDFTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6A2</accession>
    <name>A0A132B6A2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_630318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062290.1">
        <property type="nucleotide sequence ID" value="XM_018211236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6A2"/>
    <dbReference type="STRING" id="149040.A0A132B6A2"/>
    <dbReference type="GeneID" id="28820962"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630318"/>
    <dbReference type="InParanoid" id="A0A132B6A2"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="171" mass="19340" checksum="5E211D961051ED36" modified="2016-05-11" version="1">MTSCPFCYIAEHFPPSESPNPNYELISPSAFVVLSTPLCLAFLDIMPLSPGHLLLTPRKHHEKVSDVTEEESRELGMWLSRLSRVLASVTGIYDWNIVQNNGAAAAQVVPHCHYHLIPRPNLTPELRNRSFTMFGRGQRSEIDDDEAAELAQKLRDGIACEMERIKNREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6M1</accession>
    <name>A0A132B6M1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pua rna binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062411.1">
        <property type="nucleotide sequence ID" value="XM_018216299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6M1"/>
    <dbReference type="STRING" id="149040.A0A132B6M1"/>
    <dbReference type="GeneID" id="28826025"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691357"/>
    <dbReference type="InParanoid" id="A0A132B6M1"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9017" checksum="052A33E499E80679" modified="2016-05-11" version="1">MPLVVPGINSGGDNSKTEEWMNKLVGKKLTDGPSDATSFAKQDLPKETRVIEPGSMVTKDFNENRLNVHLKEDGTVSHVDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Y0</accession>
    <name>A0A132B6Y0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GPI anchored dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_629945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062521.1">
        <property type="nucleotide sequence ID" value="XM_018211226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Y0"/>
    <dbReference type="GeneID" id="28820952"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_629945"/>
    <dbReference type="InParanoid" id="A0A132B6Y0"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF2">
        <property type="entry name" value="ANCHORED DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287923" evidence="2">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="385" mass="41205" checksum="675DBABA0DEBE814" modified="2016-05-11" version="1">MVNLFNIATALAALSVLEPTLAHPGEAHDAAHVKRELAIRDHLASHSKRALGSCEGSAQARALKDRAIARRAATATSLRQKRGLATNKPYRRDLAELEVYEENSHQQNNTGYTLNTPESTIFGANTSCVLTPEDTVGPYYVYGELIRSNLTEVQEGVPMHLEMQFIDTSTCEPIQDLVADIWSCNATGVYSGIDPSQAAGEGGLNSTFLRGVQVTDTDGVVEFDTIFPGHYTGRATHEHVVTHINSTILPNGTYTGGTVNHIGQLFFDTALRAEVEALYPYNTNTQAVVSNDDDAWAPSAASAEYDPFVEYVMLGDSLSDGLLVWISIGVNTTANYTDLAYIASYWTEDGGEVNADDPFNTNMGSGSSNSSSNGTSSASGSASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B790</accession>
    <name>A0A132B790_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_339504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062630.1">
        <property type="nucleotide sequence ID" value="XM_018206855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B790"/>
    <dbReference type="GeneID" id="28816581"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_339504"/>
    <dbReference type="InParanoid" id="A0A132B790"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="165" mass="18450" checksum="A4474FBEE13B9AE1" modified="2016-05-11" version="1">MGVLSTESGMKLSEVLEKLETLFKYSGMEENEVRVETELISEIEPYELRSDRGLESVAEAYEFREEGGKVSAAVSNLGKQVIREVNPQFSQSVSISTFWDFARIQRCQGHHPTPSPQLKLACSLEWYDAALANLSMIFESFFTPRQEPPAALTALVRIGPPGEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B880</accession>
    <name>A0A132B880_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_629844</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062960.1">
        <property type="nucleotide sequence ID" value="XM_018211223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B880"/>
    <dbReference type="FunCoup" id="A0A132B880">
        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B880"/>
    <dbReference type="GeneID" id="28820949"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_629844"/>
    <dbReference type="InParanoid" id="A0A132B880"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="106"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ08605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="469" mass="51213" checksum="C88F142BE4CD9BBE" modified="2016-05-11" version="1">MSDSDGEYVADDLSDDDIRAHQVSRHGTRSTGPVRGPAGSSTRGGDTNAGTSRRRAAWEDIQRSWDTVVEGADGSINSAVEGLREAGKRKRLLRDTTPLQRGIIRHLILILDLSFAMIEKDLRPTRYLLTIRYASEFVTEYFEQNPISQLGIIGMRDGLAVRISDMSGNPTEHIEKLKKLRDQQPQGNPSLQNALEMSRAALFHAPSHGTREILIIYGALLSSDPGDINETIAALITDRIRVSVVGLAGEVFICSELCKRTNAGNDSSYSVALNEQHFRELVMALCTPPVTRTKKQSQSSLLMMGFPSRTSGAGKAMSFCACHSKLTRGGYLCSRCESKVCSLPAECPACGLTLILSTHLARSYHHLFPLNNWVEVPWSEAKKSKACFACLTPFPEVPVKLNGSHTDVEIKGNSESGRYACQSCSNHFCVDCDVMAHETVHNCPGCQSDVRGSISQQDHAANSDAMVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8P7</accession>
    <name>A0A132B8P7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_764129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063133.1">
        <property type="nucleotide sequence ID" value="XM_018221626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8P7"/>
    <dbReference type="GeneID" id="28831352"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764129"/>
    <dbReference type="InParanoid" id="A0A132B8P7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="671" mass="75698" checksum="EDD5CDCA8D2C4D96" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8R2</accession>
    <name>A0A132B8R2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_741623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063141.1">
        <property type="nucleotide sequence ID" value="XM_018220732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8R2"/>
    <dbReference type="GeneID" id="28830458"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741623"/>
    <dbReference type="InParanoid" id="A0A132B8R2"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="28897" checksum="E04962D97D3590DC" modified="2016-05-11" version="1">MAEPTIDSSSTFHCFPQLPVELRLPIWELARDALPGRVIELIEELVTFDGFEGRWLNDMDAERFVISRSGEEGCRSTPEQTFFTVRDSSVSLLSVSRESRHCTLNNYYNLFRDGVNGSVPSVPFDFDKDVLYLRAASHCTSHFLVNEPKLLAGNVKFLASIFVMPSLMDTLCLQNVGELGSVETIFILMEAAWEGDLAIYKQYWTDLLPQYHLSPIKDSDGLASLIRDPDWKIDHQKCWRSEDTSESCKRATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Y1</accession>
    <name>A0A132B8Y1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_676752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063217.1">
        <property type="nucleotide sequence ID" value="XM_018213622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8Y1"/>
    <dbReference type="GeneID" id="28823348"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676752"/>
    <dbReference type="InParanoid" id="A0A132B8Y1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="39948" checksum="5A753309742938BF" modified="2016-05-11" version="1">MGDRSRLIGGSALHDDDPNLDEDGQKEDINTRELGYAKDPDTTPPLSSRPSLLSVADLKRKAEEEEQKAQRQAGWERVDKAIEKAEFEEREYWDQFTQAQEIQKKEEASKTSSALSRGKTFHQREKEKAAAESRAGTRRASKTPSFELPDLLVALASHMLYSLFASGESRSTPEPTSHSFDSATDLWRPGGDGFGKKATVAVKRKSNQNKGRGGKASGNKAPGVHKRVSDLGGSVEKESSSLPEESGDTASSLPELNFSSPDKSAALQENNEVTSSMLGPRASSPTPSQSSTEDCFDDNSKKFGTWARANPQQSEDEPRLFPSPEHDFECAEAGESEPEGKSNDLASAEGKPEDGGKESDFETFSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B926</accession>
    <name>A0A132B926_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_336990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062522.1">
        <property type="nucleotide sequence ID" value="XM_018206827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B926"/>
    <dbReference type="GeneID" id="28816553"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_336990"/>
    <dbReference type="InParanoid" id="A0A132B926"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="63"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="43265" checksum="781803FD8F6CB6F8" modified="2016-05-11" version="1">MAPSLTETVLEVADQINGKAASLSLGSETKTDTSAKDGAPAVQSPQHKEPLKLSGALDHFQSFDVTPVIGKEFVGVNLAKWLRAPNSDDLIRDLAITISQRGVVFFRKQDDITNDLQKELVQRLGELSGKPSTSKLHIHPVSNSGRELGGKDDEISVISSQQAKKFYQDRFKAQKKQSAKQAWHSDITFEPVPSDYALLRLTEIPSTGGDTLWASGYEVYDRISTPVQKFLETLTATYAQPVFNETAQKNGFKIYTEPRGAPENIGEKLEAIHPVIRTNPVTGWKSVFAVGHHVQSINGLAEGESKGLLEWFTSLVVENHDLQVRHRWQNVNDLAIWDNRSVHHAATPDYINLGLGERTGQRAVSLGERPYLDPESKSRREALGLQDAVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAL7</accession>
    <name>A0A132BAL7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_788314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063815.1">
        <property type="nucleotide sequence ID" value="XM_018223159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAL7"/>
    <dbReference type="GeneID" id="28832885"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788314"/>
    <dbReference type="InParanoid" id="A0A132BAL7"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="215"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="735" mass="82992" checksum="DF31783E24E6A938" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAR2</accession>
    <name>A0A132BAR2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_741209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063857.1">
        <property type="nucleotide sequence ID" value="XM_018220680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAR2"/>
    <dbReference type="GeneID" id="28830406"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741209"/>
    <dbReference type="InParanoid" id="A0A132BAR2"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="36142" checksum="9F9EC27DAD05A84A" modified="2016-05-11" version="1">MATMRAIDIKDGTGPVSHLFMNSDIPKPQPGKSQALIKIHAFGLNRMDLMQREGKYNVPPQGGKILGVEFSGVIEGLGSESDFKIGDEVFGLAYGGAYAEYLVSSTRMLIRKPKELSWTVAAGIPETWITATQALHLVGCFKPGDNVLWHAGASAVSIAGIQLAKAAGAKSIFVTAGSDDKIQFCEELGATKGFNYHKDDWVKGVLGATDGHGVDVTIDFIGKNNSQGNFEAAAMDGKIVQLASMSGSKLEAGLDIGLLENKRLRWEGSRLRSRDLDYQHKLRDLLVEFALPKFVDGTFQVPIEKVFDWKDIQEAHALMESNQSKGKIICIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAU6</accession>
    <name>A0A132BAU6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_764135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063142.1">
        <property type="nucleotide sequence ID" value="XM_018221627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAU6"/>
    <dbReference type="GeneID" id="28831353"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764135"/>
    <dbReference type="InParanoid" id="A0A132BAU6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288073" evidence="2">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="19201" checksum="DA1480FDE8525ECF" modified="2016-05-11" version="1">MHYTTLLAPLLLAAPVLGQGFTCNNGEIFDNYCCEGGSFIGPVISSFSSSLSSAGSSRSSSLSDAASSRSSSLGAAASSRESAQSSIQASESSRFSNSGIQTATTDMAAAITARAVLKRAITTEVSSGLTCVGDSVSMDTENVQSGSSSDGTTSTSTGTGAGAATTTSSSSAGAAFMTQAPMLAVGAAAAFAYGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAY8</accession>
    <name>A0A132BAY8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_676226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063788.1">
        <property type="nucleotide sequence ID" value="XM_018213568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAY8"/>
    <dbReference type="GeneID" id="28823294"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676226"/>
    <dbReference type="InParanoid" id="A0A132BAY8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="53897" checksum="791E5E7764A31DA5" modified="2016-05-11" version="1">MYYSNFYWSAYTPINSNESFANNGYTYDVSQILNDSGDGVDIEKYKAYGPPYFSGANVFGQGAWFAWYPLTLFYVSIQHYEALKRSFYDMYKGIRYRSSAFGDNDDPHSRMMRAYPEVADWWFIGVLLISLVLGIIALKAYPVDTPVWTLFAVVGLSAVFLIPSALLLANANVTMGFNVLFQLLAGYWFVGNPEALIIVTAYGQNFNSQAENYISDQKMGHYAKIPPRAVFRGQMLSVLVNCFIFVGMLDWMVQSFDNGTLCEWNNPQHFVCTDAVLVFASAIEYGAFGVKNFFTLYPFLPWCFLVGGLVGIGWGVVQKFGPHFKSMCRRRWSERTFATWDTWMFRPMELFAWFDPAVFWAGALNWTGGNNLSYATNGIYISFIFMYYIKRNYGPWFEKYNYLLEAGFDVGVAISGIIQTFAFDFGPSITLNWWGNTVSTAGVDYVSYNQNASLYPIPASGYFGLAPADFPMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBV5</accession>
    <name>A0A132BBV5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_598147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063844.1">
        <property type="nucleotide sequence ID" value="XM_018210023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBV5"/>
    <dbReference type="GeneID" id="28819749"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598147"/>
    <dbReference type="InParanoid" id="A0A132BBV5"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00929">
        <property type="entry name" value="PIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288115" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="38227" checksum="D581A5027AC98213" modified="2016-05-11" version="1">MQITLALATLATVASAAIGSSPTASAPAGCSTSYSGAFEITILNSTTPRQSTTCGQAGYLTVTLADSILKDSQNRQGEIVANYQFQFDNPLQSGAVYTQGFSVCNNGSLALGGSNIFWECQTSDGPGIGTYYNLYSQSTGAQCEPILINIIPCDDSSSTSTGVVGQSSDGQPTGTSVGSVVSQITDGQPQATGTPGSITTAPVSQISDGQPQGTTIAPKPTGCVVSQISDGQIQFITSCPTPTPTPACVVSQISDGQVQYTSCASTLVTSAPVSQISDGQIQATTATSAPVSQISDGQIQATTATSAPVSQISDGQIQATTSAPSVASTSLAVVSQISDGQPQAPNATSTPLQVTGNSATSLNIASTFAAVMVGFAAMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCF8</accession>
    <name>A0A132BCF8_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_787708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223097.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132BCF8"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_787708"/>
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    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
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            <begin position="202"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="241"/>
            <end position="264"/>
        </location>
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            <begin position="303"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
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            <begin position="568"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="667" mass="70899" checksum="C8AF35436D9DE587" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCT7</accession>
    <name>A0A132BCT7_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_538709</name>
    </gene>
    <organism evidence="8 9">
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064590.1">
        <property type="nucleotide sequence ID" value="XM_018208132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCT7"/>
    <dbReference type="FunCoup" id="A0A132BCT7">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="GeneID" id="28817858"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_538709"/>
    <dbReference type="InParanoid" id="A0A132BCT7"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="108"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="498"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="KUJ10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="498" mass="53770" checksum="18205D8DFE08145A" modified="2016-05-11" version="1" fragment="single">QRSTRDPEKFPTVQLFLLAIVRLAEPIALTSIFPYAWPLVKKFHVGDENDASFYAGLLISAFALAESLTGMFWGGLSDRIGRKPVLLMGCTGTMMSMILVGFASNIYMALAGRAIGGVLNGNIGVIQTMVAELVTKPEHEPRAYSIMPFIWSIGTIIGPALGGTFADPATSWPDTFSQDGLFGRFPYLLPNLLCASLLLISILAGYFLLEETHPDMQPRVLLPDDTYVSEETPLVATADAIKTPAVDLRADTYGTFEGSDDSKWRHATEKNRTPKIFSKRVVALIVALGIFTYHSMTYDHLLPIFLEDARGETNISILTHAAIGSPLSSGGLGLSVQKVGVIMSINGVIALFVQAVVFPLAAEMLGIHRLFILVSVLHPIAYIIMPYLVYLPATWVTAGIYTCLTVRNMLSILAYPVLLILIKEATPSPSVLGKINGLAASAGAACRTVAPPVAGYLYTLGSRMDFSGLAWFGSAFVASIGAIQAFTIKRTKKEQGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD23</accession>
    <name>A0A132BD23_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_761465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064099.1">
        <property type="nucleotide sequence ID" value="XM_018221549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD23"/>
    <dbReference type="GeneID" id="28831275"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_761465"/>
    <dbReference type="InParanoid" id="A0A132BD23"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="46107" checksum="064DA30DE9D3DEEA" modified="2016-05-11" version="1">MSTFSPQYHRSRFDNVEDVESYVPGGFYPVRLGDIFHDRYKIIHKLGFGGFSTVWLALDQREHRHVALKIVRADASSNCSELAILQRLQAIPTPHPGRQHVASLFDHFTIDGPNRTHRCLVSDVAGPSVTTLNDFPGKGAGSQRLRADLTAKLAKQAAEALDFLTSTNEWSEDEIYQRFGVPQKDPILTITGSEPGQSAPRYLVESAGLIDPQFLTEDILLLDFGQSFPSDTPPPAEEVGIPFSYCAPEVIFDSKVNKYSEIWALGCIIFELRAGQQLFASWSGGQDEILRQMIQTFGRLPDPWWAAWYKRADFFDDDGKPNKDWSGGIQKAVECPIDDLIADIGLEDDENDIPREAEAMLEASFKKVPEEEAVQLKDLLESIFKWVPGDRASLGEILNHPWFTTIYETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDF6</accession>
    <name>A0A132BDF6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064229.1">
        <property type="nucleotide sequence ID" value="XM_018215971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDF6"/>
    <dbReference type="GeneID" id="28825697"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689780"/>
    <dbReference type="InParanoid" id="A0A132BDF6"/>
    <dbReference type="OrthoDB" id="3556767at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="10190" checksum="B1FFD94C47CF822E" modified="2016-05-11" version="1">MASPPPAYDTSTSLGADSVDPDQTTHPWLTPTAILPSYSTSSPLCWMEEEALGILRTSHDFDAIRLICRFVPSLDPSVAAALLSARRNGWLNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDG7</accession>
    <name>A0A132BDG7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064801.1">
        <property type="nucleotide sequence ID" value="XM_018220552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDG7"/>
    <dbReference type="STRING" id="149040.A0A132BDG7"/>
    <dbReference type="GeneID" id="28830278"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740158"/>
    <dbReference type="InParanoid" id="A0A132BDG7"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41870" checksum="5689CF99556F214B" modified="2016-05-11" version="1">MPQKSQNWDLHRDEIEKLYMQRGFTLQKLQEAMSMKHDFTASTRAWKTKLEEWKLRKNKSRSILRKGYPRQRREQLKGSPASIPPSQEKSPSKDLSIPQLPTDVLYNWTADDPAAIPETSFQTSPSNPVYNTLWRNSIGDTVHQCSHYTSISTLGNSYLETPPLINSSLMLFSTRPPSVSLRLLANCPEQAPQALEILLRSWKPGGEHMWFAKRFLADSAYCRTIVGVNWTRWDHTDETLFDLVDQFVPEDEQDLLRKALLRADVKFEHPLGRLNAQWAPTWRLAIRETTWDRAKHQILKMEVRDRLLRCALSVVAGALVRSQETRLELLAMTGESELFEESRMDKAWILADCHEQGINIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDH7</accession>
    <name>A0A132BDH7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_257363</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064668.1">
        <property type="nucleotide sequence ID" value="XM_018206247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDH7"/>
    <dbReference type="FunCoup" id="A0A132BDH7">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BDH7"/>
    <dbReference type="GeneID" id="28815973"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_257363"/>
    <dbReference type="InParanoid" id="A0A132BDH7"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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</entry>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30762" checksum="5D8B8E18445E53B7" modified="2016-10-05" version="1">MATVEHCLYCFETLAARLEKRTPMTLYQVQSSWAAYPKEDSPPTTKPKLPALQRLSESRSSSTGSSTPSSSTSTTSLTPASSLSSFSPIGLHPRRTSQRSSTLTESPLFVTWNTLSSSSPHQKSLRGCIGTFTSTPLSAGLSSYALASAIQDDRFSPISLRELSSLEVSVTLLTDFETCPSPLDWEIGVHGIRISFYARNKRYGACYLPDVAVEQEWDKEETVVSAMRKAGWGGRREKWMEVGDLKVVRFQGVAESVGWGEFRRWREWVEKGKEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT61</accession>
    <name>A0A194WT61_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Vacuolar assembly protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_689444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065214.1">
        <property type="nucleotide sequence ID" value="XM_018215909.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194WT61">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WT61"/>
    <dbReference type="GeneID" id="28825635"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689444"/>
    <dbReference type="InParanoid" id="A0A194WT61"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="386"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="916"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1282" mass="141398" checksum="8186688BD383A803" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUJ5</accession>
    <name>A0A194WUJ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_654308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065985.1">
        <property type="nucleotide sequence ID" value="XM_018212295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUJ5"/>
    <dbReference type="STRING" id="149040.A0A194WUJ5"/>
    <dbReference type="GeneID" id="28822021"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654308"/>
    <dbReference type="InParanoid" id="A0A194WUJ5"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="662" mass="74171" checksum="C0CCA2ED11F7DAE0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV33</accession>
    <name>A0A194WV33_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_688330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066185.1">
        <property type="nucleotide sequence ID" value="XM_018215685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV33"/>
    <dbReference type="FunCoup" id="A0A194WV33">
        <property type="interactions" value="725"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WV33"/>
    <dbReference type="GeneID" id="28825411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688330"/>
    <dbReference type="InParanoid" id="A0A194WV33"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="106" mass="12029" checksum="38D48DE2F292D555" modified="2016-10-05" version="1">MVNVPKTRRTYCKGKDCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTACKTKAQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVD6</accession>
    <name>A0A194WVD6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_786461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065912.1">
        <property type="nucleotide sequence ID" value="XM_018222986.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVD6"/>
    <dbReference type="GeneID" id="28832712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786461"/>
    <dbReference type="InParanoid" id="A0A194WVD6"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="386"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1655"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1772"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1303"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1466"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1726"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1729"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2133" mass="231258" checksum="C2FFA2C0ADEF7911" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVE9</accession>
    <name>A0A194WVE9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065999.1">
        <property type="nucleotide sequence ID" value="XM_018220437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVE9"/>
    <dbReference type="GeneID" id="28830163"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739069"/>
    <dbReference type="InParanoid" id="A0A194WVE9"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="504" mass="57998" checksum="9E71E72967F5CF28" modified="2016-10-05" version="1">MASGYRSRSRSKLIGSLSLYVAVEQFSDLKCLISNERRKTTWTRVAPCCGADAPPPPGFSRLVKSAQHSMIKSIDYNVAIASNQTLVHGFVQEPNGRGTLSILLSCLAVLLLNTWTVLHLNIPPHSSTWRNYLHKVKWWIIALICPDGLAVSSCEQWRNARRSVKALKKTYPWWTITHGFYAEMGGYRIVSADGQRQMYIFRVKELIWLTEHGVLVIPEITLEELHDKSNADWLVKGIALAQSTWFMLQICARVNQHLTIATLELATVAFIGCTGLMYFFWWHKPMDLETFTPILDPGLTSAQLCELARGICLLHEVSEWYRPPPKEAHDHGWDWFWFEKPMNIMHLEVISRGNQVPADLRAIVKDNFTAHARVTSWFMPAVNESHSSEWGPWDHLCVFSIGTMFNGIHCAAWKFTFASRTESVLWKTSVCIMLAVIYLWVPISAMTWWLPNRSRLKSLPYWFATFCYFLARIYLLFEVFFGMRALEPTIFLSVNWSQYIPHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVH3</accession>
    <name>A0A194WVH3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_786121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066321.1">
        <property type="nucleotide sequence ID" value="XM_018222954.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194WVH3">
        <property type="interactions" value="1442"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVH3"/>
    <dbReference type="GeneID" id="28832680"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786121"/>
    <dbReference type="InParanoid" id="A0A194WVH3"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to amino acid starvation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:GCN2-mediated signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of translational elongation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:rescue of stalled ribosome"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
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        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
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        <property type="entry name" value="TOG"/>
    </dbReference>
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        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1679"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1996"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2647"/>
            <end position="2688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2688" mass="293684" checksum="FAA2B974612222D6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVV0</accession>
    <name>A0A194WVV0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_700047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066446.1">
        <property type="nucleotide sequence ID" value="XM_018217098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVV0"/>
    <dbReference type="FunCoup" id="A0A194WVV0">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVV0"/>
    <dbReference type="GeneID" id="28826824"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700047"/>
    <dbReference type="InParanoid" id="A0A194WVV0"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="10">
        <location>
            <begin position="373"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="11">
        <location>
            <begin position="689"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="871" mass="96504" checksum="9AE50016DA6698A9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW71</accession>
    <name>A0A194WW71_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066187.1">
        <property type="nucleotide sequence ID" value="XM_018215687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW71"/>
    <dbReference type="GeneID" id="28825413"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688334"/>
    <dbReference type="InParanoid" id="A0A194WW71"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="158" mass="17901" checksum="C1512F9CD7DF97D1" modified="2016-10-05" version="1">MTDFSFFPKTRTNNFSALPYRAVSEITSLPATIVHMGKLGLGCNYHTMLILCQIIHTTVDIIGFGAILPRMKPRNMPTWIQFVAATSAGGRLSSRSVCDCRTISMSSLVQGDLVTPRTISENCWVRYNPEQQWYWLSDQSPDEVTLFLQFDFAIRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWD5</accession>
    <name>A0A194WWD5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_688378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066247.1">
        <property type="nucleotide sequence ID" value="XM_018215693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWD5"/>
    <dbReference type="GeneID" id="28825419"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688378"/>
    <dbReference type="InParanoid" id="A0A194WWD5"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23412" checksum="4A85729F48E30DE7" modified="2016-10-05" version="1">MSPTIILAQTLSTSIVLIASGGIASLSLFDLPILQSQPASRSLPSTRWLFSRGSHIFPPASLTSALGFLYLSFLSLGPSRSLGQALRIMKNGGSPKVYGYLAAAILSFSIGPFTQLAMIPTNFQLIEMNEKKGGKRSARSALESDQGGKMRERKAIDSVNGEGEGAESTDLSGPQERTEVKTTKEDDARARTLLKRFETLNAVRAGLIGAGGIVGLVTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWG6</accession>
    <name>A0A194WWG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_205449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066678.1">
        <property type="nucleotide sequence ID" value="XM_018205817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWG6"/>
    <dbReference type="GeneID" id="28815543"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_205449"/>
    <dbReference type="InParanoid" id="A0A194WWG6"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="56171" checksum="9032596408A99EA3" modified="2016-10-05" version="1">MESSLLSPHTYTGGKRKKITFFTSSEYGQANVILAVVYELLLLQAYEIDIASFAPLKNRIQDINALVSNNSSPARFHTVTGLSALEALTAKKEFIGPYRPGIRGASDTYRVTLPAIATTWDENDYMTGLESCINILRSISSDLIVVDPLMSQGLEACKALSRNYVVLSPNTFQEICKKQQPLFTQLCRWPAVSSAFRYPVPWYLIPANIYLKFLLLWILITSPKVKGLINWRQSRGLPKLPPVFNIWEKENKYLVVSVPETEYPCYVPPNVIPCGPILLPVRPVSEHDPKLQAWLEGAPTIMINLGSHIRMDDQMAQQFASGLKIVLHQMPGIQILWKLKTSGGLAVSSDAKTTSGFSGTGIKKESLEAIEPWILSGSVKVLEWLSVDPMAVLQSGNIVCSVHHGGSNSFHEALSAGVPQVILPCWLDTLDFANRVEWLGIGVYGSRNAAPSVEADELSQALLKALGNDHEATRMREKAKELAMISARPGGRRKACEEIIGILLSSSEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWS2</accession>
    <name>A0A194WWS2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_738216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066781.1">
        <property type="nucleotide sequence ID" value="XM_018220347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWS2"/>
    <dbReference type="GeneID" id="28830073"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738216"/>
    <dbReference type="InParanoid" id="A0A194WWS2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11358" checksum="8D1B4A7FE4E4258B" modified="2016-10-05" version="1">MGEPVMFFWAFLCGLCMLFCSGVYLGYIGFEFKFSVRINRNNNVIPAQEAAIPPLDEHPDSANSTESASIFEQLLGQEDIIPSYDDYPDGAYEAADEREFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWS3</accession>
    <name>A0A194WWS3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_786269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066489.1">
        <property type="nucleotide sequence ID" value="XM_018222964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWS3"/>
    <dbReference type="FunCoup" id="A0A194WWS3">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWS3"/>
    <dbReference type="GeneID" id="28832690"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786269"/>
    <dbReference type="InParanoid" id="A0A194WWS3"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="96"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="604"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="805" mass="85988" checksum="5746498E3B70073D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXQ3</accession>
    <name>A0A194WXQ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_208026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066814.1">
        <property type="nucleotide sequence ID" value="XM_018205837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXQ3"/>
    <dbReference type="STRING" id="149040.A0A194WXQ3"/>
    <dbReference type="GeneID" id="28815563"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_208026"/>
    <dbReference type="InParanoid" id="A0A194WXQ3"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32658" checksum="321DE75788F199AF" modified="2016-10-05" version="1">MFPPRQFILCSNSTETTKFSYHHNMALFTKAAETMGALPQKYEPLTGQQDDEATQQDSLVFNFPRDRRTLRLKIIGLGFCLGILVATFLILIVVGLILSSVVTHIYPAAESHCAPGTEAVADLGHTAFGLQKTGPFTCGENADEARALGCIWDVMNFAWEHPDCYDAELVQEFEALGPWTFYHSSRADTEVPESNMLSVIPDDQVGDHLELMWTDRRYHSMHCIFAAKLVHRAVERGGKVQGKLASINHTNHCAMSLQNRDKEAVRWMERYHTVVPLDAIVTRATVQYPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY55</accession>
    <name>A0A194WY55_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_757172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066974.1">
        <property type="nucleotide sequence ID" value="XM_018221407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY55"/>
    <dbReference type="GeneID" id="28831133"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_757172"/>
    <dbReference type="InParanoid" id="A0A194WY55"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
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    </dbReference>
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        <property type="entry name" value="Terpene_cyclase-like_2"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="39144" checksum="29AC0883D0A600F7" modified="2016-10-05" version="1">MASRIFFPDLEANWMWPRRVNPHTPEIKQECLEWVGRFGAFTPAAQKAFDKCDFNQLRSACDLMNLFFIFDEHSDKCNGDEVWNQVDIIMDAFHFPEKPRPEGEWIGGEVARQFWSRIIGISTPTFQKRFLDTWEEYLQGTAQQAEDRCRSKKVICDIATYLTVRRRTIGARPSFNIIEIDMDLPDEVVGHPTIRELELLATDLTIIANDILSYNKEQASGDDEHNLITIVMKEQNTDVQGAIDWTAKLHAEMIHRFNKLYLFEIPKWGGPLDLDVQSYVNGMAQWVGAYVQWSYESERYFGKRGLEVKKTRMLSLLPKNSKVNGQGEIGPVVLDDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY57</accession>
    <name>A0A194WY57_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067263.1">
        <property type="nucleotide sequence ID" value="XM_018213324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY57"/>
    <dbReference type="GeneID" id="28823050"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673014"/>
    <dbReference type="InParanoid" id="A0A194WY57"/>
    <dbReference type="OrthoDB" id="10590040at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="23068" checksum="2D7AEEF316163906" modified="2016-10-05" version="1">MTTPSPSPSPRSTAYSTGNSPSSIKLPSPAAMPSIHSYVSIFDDLHARTRAEAIAQATALADGDIGLRLKIESELNAKFDKICEGAYIAMQLTPFFKEMSEDLKSAWYDKFVWDSVYSDEEFPGDDSELEEFKEWFFTRLEDADEDTAFEYSGAVKNGKAVEDDKAVKDDGAAKRGAMVDGHWVGDGESEDRYADGETESTDGGAKLSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZA6</accession>
    <name>A0A194WZA6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_699168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZA6"/>
    <dbReference type="STRING" id="149040.A0A194WZA6"/>
    <dbReference type="GeneID" id="28826763"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699168"/>
    <dbReference type="InParanoid" id="A0A194WZA6"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="293"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="397"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="563" mass="59302" checksum="8D230062B7A2D188" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0L9</accession>
    <name>A0A194X0L9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_146514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068098.1">
        <property type="nucleotide sequence ID" value="XM_018205359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0L9"/>
    <dbReference type="GeneID" id="28815085"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_146514"/>
    <dbReference type="InParanoid" id="A0A194X0L9"/>
    <dbReference type="OrthoDB" id="10461747at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="309" mass="34106" checksum="9A9C509797E92C4F" modified="2016-10-05" version="1">MALVSSEQSPIFQLLDLAFAPMGLEPDNQFQHLNFSVFGSPQSSPPAFPDPIFSSSRSRPRSPVAKRSWIWAHHAPNSRKFHTGTHSHWDCAYCSKSFKLVSGTGKPMRHLEIAHGILRPAKRVAGVTCSASTSLASERFTSQISGINKESWNVSKEQMSLDPHFASCTDYCGDNGCSGAFSNDMDIWLDCSHSGFESHTSETASISPTATSISTFDSGFEDTFSSAESSPSSYMDHGSNSLSRSPPTKSASFTTRRSWIWQHHESFSWNDEGSSDSDWRCAYCWKVYRKSSGTGKGMKHLRDAHGFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1N5</accession>
    <name>A0A194X1N5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_152889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068458.1">
        <property type="nucleotide sequence ID" value="XM_018205424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1N5"/>
    <dbReference type="GeneID" id="28815150"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_152889"/>
    <dbReference type="InParanoid" id="A0A194X1N5"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="589" mass="65247" checksum="EF6B2E377A5043D4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X200</accession>
    <name>A0A194X200_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_620563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068576.1">
        <property type="nucleotide sequence ID" value="XM_018210919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X200"/>
    <dbReference type="STRING" id="149040.A0A194X200"/>
    <dbReference type="GeneID" id="28820645"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620563"/>
    <dbReference type="InParanoid" id="A0A194X200"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="43342" checksum="021A0D04FC221710" modified="2016-10-05" version="1">MSGADPLYTVFIRLPFPRGDFVDPPSVEWDAAKDKALWKILSKASKNSDIDWNELASKFEVTLAFLLQQAAWLYERQLSQVRAQMRKVGVSKTSAAPSPIPGSAADSAGGESMRRTGSGGGGPRVTSALSARKDSPIPGSIPNTPGRSMAPPFSRTSSANTTVTSRNFAPQTSPRPAQATLNRRSLSPKPKSRPTSIAIDPPTRSPRPDPLSSPSVSSSDSSSDDSPPLQSRLLRRPPRFSNKLGQSEDADDDDDEPAFMPFSTPAEAGTTHHDPSATLRGDPRSMGRKVPVYRKSMDAALQSATSDSSASSTPATKRPGPLHGLHRQRPTGPLSPKRTAELAGRSPGMKGKGRDGSEGSPSMGSSFSDLDDASVTQSALEEALASNMQAGGMASRMSTISQALRSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X218</accession>
    <name>A0A194X218_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_753490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068394.1">
        <property type="nucleotide sequence ID" value="XM_018221278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X218"/>
    <dbReference type="STRING" id="149040.A0A194X218"/>
    <dbReference type="GeneID" id="28831004"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753490"/>
    <dbReference type="InParanoid" id="A0A194X218"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="37588" checksum="5949070F840D61D4" modified="2016-10-05" version="1">MARLSELYQYDNLPTQTSFRVLELLPGQEGDQISCLLHTVDWSNPLEYEAISYAWGDPNAKESITCHGRGLEVTRNLHTGLTHLRLQDRSRILWADAICTNQSDIPERSSQVSQMLRIYQSAKAVLIWLGPDSEEQYAQFAIHSIRTISDFLCHKVGISVSDLSSISDVYQEVVFKNRDSLPLPNACEFSTEAMWKALVWFYSHSYFTRVWAVQEINANKARLLHCGHAMIEWGRVALVAGYIIMETAFSKSFGFTGAHCWWAAIMTTERIRQPKNWLFMLYLASNFSSTDPRDQIYGLRGLMKFSDGAGLLDPDYGKSTVDVYREGQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2D7</accession>
    <name>A0A194X2D7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_784297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068693.1">
        <property type="nucleotide sequence ID" value="XM_018222772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2D7"/>
    <dbReference type="FunCoup" id="A0A194X2D7">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2D7"/>
    <dbReference type="GeneID" id="28832498"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784297"/>
    <dbReference type="InParanoid" id="A0A194X2D7"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000236">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp9), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000369">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="72061" checksum="6FCF3B6465D760FF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X314</accession>
    <name>A0A194X314_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_143351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068926.1">
        <property type="nucleotide sequence ID" value="XM_018205330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X314"/>
    <dbReference type="GeneID" id="28815056"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_143351"/>
    <dbReference type="InParanoid" id="A0A194X314"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="47294" checksum="D2FFEF2D48090B80" modified="2016-10-05" version="1">MPEAVSNSDKGTVRKIRAHKKSRQGCGNCKLRAVKCDESRPICKRCKAYGVVCNYGRKSPDLELSSSGGFHVSVLNDSSLSSPEAGVPKSIAPSLKQGLAASLESYASDGLSRWEFELLHRFQLRTIYTVTTAKSLAIYQSSILKYACSHPYLLHGVLALTLLHDRYFSPLGLNSSLTPSEVYHWGRSLNLYSLALTKPIAPASRDPLWATAAFLGVLSIAHVEARTAKDSWPYAPPSLMDLSWLKMSEGKKTIWKDGNAFMEESDFRILAHEQQGNYQPPLVYGSKEGICTLPSNFLAYFAIGDGFDLIDNPYYASVYSLAQSWKLTSAFQVIMNWIFYITNMENRYKTLLRSKDPRALLLMAYWYRLAAETKHWFLMRRVHVECESICLYLEQHYSQDHELQILLEYPRSILALGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3U6</accession>
    <name>A0A194X3U6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_783923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069210.1">
        <property type="nucleotide sequence ID" value="XM_018222734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3U6"/>
    <dbReference type="FunCoup" id="A0A194X3U6">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3U6"/>
    <dbReference type="GeneID" id="28832460"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783923"/>
    <dbReference type="InParanoid" id="A0A194X3U6"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="100"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="37947" checksum="198E67F998799EE6" modified="2016-10-05" version="1">MSRNYHHSTSSGGTNTPPQSLSNSWSMPAAVTGLLRRFSTEDPVKGKKHTPVNTPPYDDWSNGFDGVYTPPGRTASPFQPPPLYPVILKGHSSSTPASAKLLNRGLAEEIRLLVPPRLQLCEEWNLVYSLENDGVSLGTLYKKCDELRGLRNGFVLIVKDGEGSLFGAYLTDAPHPSPHYFGTGECFLWRASILSSSFPTNLPPPPSADTTNMARITTISTSATTTTAQSSRLLSPTTSSLSNHHSISPNTSTASLAPRSPNSPSFQSGVSTPDRIRFKAFPYSGVNDYLMLCETGFLSLGGGDGHYGLWLDDSFERGISSHCLTFGNEPLSEEGEKFDILGVELWSIGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5H8</accession>
    <name>A0A194X5H8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_588464</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069781.1">
        <property type="nucleotide sequence ID" value="XM_018209483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5H8"/>
    <dbReference type="FunCoup" id="A0A194X5H8">
        <property type="interactions" value="1121"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X5H8"/>
    <dbReference type="GeneID" id="28819209"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588464"/>
    <dbReference type="InParanoid" id="A0A194X5H8"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="398" mass="44631" checksum="B48E076CEC66A786" modified="2016-10-05" version="1">MSPSSARNVDRITELQNSLTSLSKVALENEDERKKLLAVLRAQVAVLETPLEVVWRMMMEPHQSTALRSAQGMGLIEPIVSSSPRTATELATITKCDKQLIVRILRCLSAMKMVDEVDYETYASNPTTQILTVPSVGGGFKFMFDEAAVSVVHVPAFLSKTGYKNPEGPETCFQSAFNTDLQLFPYLMANPERMGHLNDLMTGQRMNRTEWFDFSDVDSILFDGMDTKDSDATLLIDIGGGRGHDLEAFRNKFPNAKGKLVLQDLPPVIADIEALDSSIVRMEHNFFTEQPIKGARAYYIRSCLHDYNDADDRKILRQIVDAMKPGYSKLLIFEWILPDVGTPLYPALLDLNMLALFSGMERTETHWRNLLESVGLEVVKVWSIGKETEGLIEAMKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X841</accession>
    <name>A0A194X841_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_719036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070634.1">
        <property type="nucleotide sequence ID" value="XM_018218461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X841"/>
    <dbReference type="GeneID" id="28828187"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719036"/>
    <dbReference type="InParanoid" id="A0A194X841"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="47718" checksum="40F132E55E9AEE32" modified="2016-10-05" version="1">MRGKGKASILLKLPGNEIGIEFHVFEVVMVQAQNVPLIPRSFEHTSETLQYLAEHIDMDHQRTLLGLPLELRRAILDFVYPSSYQKYPAPRIPFNKSQNIDYGQFPTYTLNFGWLVHYHNTILFEQYPTLGVNHILKAETLQLIKLYQQKETYEVDLMLVNDSELWVTCLSVPILINRLEKLRITVRNAGFVGGLKDHEHEIWRLPPLIDPSAADKSPQFRRALSDILLDLLQRGRGSTALSGRAITVKELTIDVRRVSVVAPYNNSSRACFPGTPYNQLCAMRRTMRWNEVFLNPQDILDPVVYHMDACLVRHGVRREDGHAVIPTIFECIGDIAVLENGEEKTRYQLETYLSGLTYVHNRMIMTSEFVTLNGLRDPESIGVDINITQKKFDGWKTRTKAARSARKLTVSKEAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9X0</accession>
    <name>A0A194X9X0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_718675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071320.1">
        <property type="nucleotide sequence ID" value="XM_018218432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9X0"/>
    <dbReference type="STRING" id="149040.A0A194X9X0"/>
    <dbReference type="GeneID" id="28828158"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718675"/>
    <dbReference type="InParanoid" id="A0A194X9X0"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17445" checksum="A6F54C5A0508F7E4" modified="2016-10-05" version="1">MPSVQRATSRLLGGPYLTTKIHLVICFHELPFIYTGNKLNVMTMPNTITFGMSKSVVAHLIKTAVQAYRAKGYKSIIHCFRHERRDCADKARFYYTVERLIDGTHAGVKYDGPARGKEYVDLAGDKEQREWHYTFVKEVGYVDFSDLDSKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBH6</accession>
    <name>A0A194XBH6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1688-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_584310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071869.1">
        <property type="nucleotide sequence ID" value="XM_018209257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBH6"/>
    <dbReference type="STRING" id="149040.A0A194XBH6"/>
    <dbReference type="GeneID" id="28818983"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584310"/>
    <dbReference type="InParanoid" id="A0A194XBH6"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="50204" checksum="3F14DD84ABCC6083" modified="2016-10-05" version="1">MSIPPTIPKVALPKAPDPHVDPAGHLRSIGAVRERCAIVLEKAKRNQLNHFNVDMAKFEDTTKFVVSIIKRDFAPDYASIPPHGRWQHFNVGGKDRIADMLAGWPSSIDPSERCRRLLDLFLVSVLLDAGAGTSWTYKSKDSGRVYRRSEGLAVASLEMFKDGLFSSNTSQPHQVDGEGLRGLTVEKMAKGLQVSDRNPIAGLEGRTGLLIKLADALNNQDLFGADARPGNMLDYLISHPTTQASSVPVVLLPTLWSVLMDGLAPIWPASRTAIDGTSLGDAWPLSTMPSDATSQPWEVIVPFHKLTQWLCYSLMQPMSKLIHIHFAGAELMTGLPEYRNGGLFIDTGVLTLKEEDEKRGLLRFKKEGELSGKGSMEVVPMFTPDDDVIVEWRAVTVGFLDLLLEEVNSVLGLQGLDKLSLVQMLEAGSWKGGREMAEISRPNTQCPPIAILSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCD1</accession>
    <name>A0A194XCD1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_62039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072171.1">
        <property type="nucleotide sequence ID" value="XM_018210911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCD1"/>
    <dbReference type="GeneID" id="28820637"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_62039"/>
    <dbReference type="InParanoid" id="A0A194XCD1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ17816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="809" mass="91310" checksum="6F4B3C193F1851C7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCM5</accession>
    <name>A0A194XCM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_615639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071857.1">
        <property type="nucleotide sequence ID" value="XM_018210733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCM5"/>
    <dbReference type="GeneID" id="28820459"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615639"/>
    <dbReference type="InParanoid" id="A0A194XCM5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="580" mass="63798" checksum="CC2110FDDEBC41CA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCV7</accession>
    <name>A0A194XCV7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">LY89DRAFT_34639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072349.1">
        <property type="nucleotide sequence ID" value="XM_018206885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCV7"/>
    <dbReference type="FunCoup" id="A0A194XCV7">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XCV7"/>
    <dbReference type="GeneID" id="28816611"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_34639"/>
    <dbReference type="InParanoid" id="A0A194XCV7"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000295">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023394648" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023394647" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="263"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ17994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119646" checksum="2CEA3FFE12799591" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEV0</accession>
    <name>A0A194XEV0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">Double-strand-break repair protein rad21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_780715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ18693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073048.1">
        <property type="nucleotide sequence ID" value="XM_018222409.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_780715"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
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    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
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    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="555"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="70356" checksum="BA48CAFA8042478F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF18</accession>
    <name>A0A194XF18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_504931</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073140.1">
        <property type="nucleotide sequence ID" value="XM_018208006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF18"/>
    <dbReference type="FunCoup" id="A0A194XF18">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XF18"/>
    <dbReference type="GeneID" id="28817732"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_504931"/>
    <dbReference type="InParanoid" id="A0A194XF18"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902767">
        <property type="term" value="P:isoprenoid biosynthetic process via mevalonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ18785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="483" mass="55127" checksum="5FC1BA3192EC2F24" modified="2016-10-05" version="1">MGLASQLLYYSVHPNQLRSILQWKLWHDPVHTRNPDKESPTLRECFKYLNLTSRSFSSVIQELNPELLVPVALFYLILRGLDTIEDDMTIPLENKEPHLRNFQNILEQDGWTYTENGPNEKDRELLVHFDVVVTEFKLVKPAYKAIIKDITDKMGNGMADYANNAEHNVNGVNTIKDYELYCHYVAGLVGDGLTRLFVEANLANQALLKRPELSESMGQFLQKTNIIRDIREDFDDKRRFWPKEIWSKHVTNFEDLFEPKNLQVALNCSSEMVLNSLKHADECLFYMAAIKDQSVFNFVAIPQAMAIATLELVFQNPEVFKKNVKITKGDACQLMMESSQNLKTVSEIFKRYVRRIHKKNNPKDPNFLEISIACGKVEQFIESIFPTQDPKALALLHKGEIAPEDARKKAESAEANKDVMYLMLAVFGTLLVISALMIGAAYLAGARFDVAVNELKKGKIFPKFDKGSEEAQGIAQQYDHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGA3</accession>
    <name>A0A194XGA3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_695810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Bacterial non-heme haloperoxidase / perhydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073521.1">
        <property type="nucleotide sequence ID" value="XM_018216787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGA3"/>
    <dbReference type="STRING" id="149040.A0A194XGA3"/>
    <dbReference type="GeneID" id="28826513"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695810"/>
    <dbReference type="InParanoid" id="A0A194XGA3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000205">
        <property type="entry name" value="Non-haem bromoperoxidase BPO-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF3">
        <property type="entry name" value="NON-HEME CHLOROPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="30801" checksum="E21BC8CE980C1639" modified="2016-10-05" version="1">MPFVTTSDKTEIFYKDWGNPAGKPVVFSHGWPLNSDNWENQMFFLASHGYRCVAHDRRGHGRSSQPWEGNDMDTYADDLLVLFEHLDLKDAMMVGHSTGGGEVVRFLGRHSTSRVSKAVLVGAVPPVMVQKESNPKGLPISVFDGFRSAMIQDRAQFFLDVPTGPFFGFNRPGAKMSQGLIQSWWSQGMMCGFKNAYDCVKAFSETDMTEDMKKIDIPVLLLHGTDDQIVPIDDSAREGIKLLKKGTLKEYPGGAHALPNLNIEEINQDLLNFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGB3</accession>
    <name>A0A194XGB3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_683101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073531.1">
        <property type="nucleotide sequence ID" value="XM_018214641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGB3"/>
    <dbReference type="GeneID" id="28824367"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683101"/>
    <dbReference type="InParanoid" id="A0A194XGB3"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="21989" checksum="198C1B9AD237A9F7" modified="2016-10-05" version="1">MSSHKEYLVMQEMRSLYGMRGLEVCASSHPSNPLYLCKSPSTYTPHKNIFAIGATDLEHKFVAIFEDELYNNIVSAIHTILPDCNWGLNVLRLGFDIKRLKNPITIHIIVADKALFEDAAYNIISMILKVMIVVGLDSSEKDSIYVNVCRTSRSDIDLCFVLNRNPDVYNSPTRLLYLSIGPVDINSVGTLSRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGM3</accession>
    <name>A0A194XGM3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_780265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073639.1">
        <property type="nucleotide sequence ID" value="XM_018222365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGM3"/>
    <dbReference type="STRING" id="149040.A0A194XGM3"/>
    <dbReference type="GeneID" id="28832091"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780265"/>
    <dbReference type="InParanoid" id="A0A194XGM3"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59315" checksum="65DD67259906C7FE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGN2</accession>
    <name>A0A194XGN2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_667296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073683.1">
        <property type="nucleotide sequence ID" value="XM_018212967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGN2"/>
    <dbReference type="STRING" id="149040.A0A194XGN2"/>
    <dbReference type="GeneID" id="28822693"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667296"/>
    <dbReference type="InParanoid" id="A0A194XGN2"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="33788" checksum="426FECD5C98D634C" modified="2016-10-05" version="1">MATLDVGELPTGDNVVIKTSSYFNRTAEDILLPSPAEVRKRALEKGFVYPGNPPPIRFSELGLIVKSGTNLTIAEAQCLWVIRKHLKCEIPVPELYGWVRDGGELFIYMKLIEGETLEARWDTLSVLERLDVSSQLKTMTTALRGLRQGGKDAFIGSINRGPLLDILFEGRPGFGPFKTTKEFHDRFAAEVSKYHPDIQNFVDPMRGQLPDEAPITFTHADLHPSNIMLTATDVKPVRVLAILDWHQSGWYPDYWEFCNMLYCVDMDGDWAKDYVPMILEKPDCFDGWWYYMNGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGS8</accession>
    <name>A0A194XGS8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_489993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073760.1">
        <property type="nucleotide sequence ID" value="XM_018207888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGS8"/>
    <dbReference type="FunCoup" id="A0A194XGS8">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="GeneID" id="28817614"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_489993"/>
    <dbReference type="InParanoid" id="A0A194XGS8"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="559" mass="63590" checksum="365120768F701CE0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHJ9</accession>
    <name>A0A194XHJ9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_612848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073607.1">
        <property type="nucleotide sequence ID" value="XM_018210639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHJ9"/>
    <dbReference type="GeneID" id="28820365"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612848"/>
    <dbReference type="InParanoid" id="A0A194XHJ9"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268253" description="Laccase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="72"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="199"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="414"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62023" checksum="9B6569C4D8297FDB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI73</accession>
    <name>A0A194XI73_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60S ribosomal protein L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_695504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074218.1">
        <property type="nucleotide sequence ID" value="XM_018216766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI73"/>
    <dbReference type="FunCoup" id="A0A194XI73">
        <property type="interactions" value="1209"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XI73"/>
    <dbReference type="GeneID" id="28826492"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695504"/>
    <dbReference type="InParanoid" id="A0A194XI73"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="26729" checksum="79298D0D23B51BBF" modified="2016-10-05" version="1">MGREKRGSIFTSHTRLRQGVAQFRTLDFAESKGYIRGVVKEIIHDPGRGAPLAKVVFRDPYRFKLHTELFIANEGMYTGQFIYAGKNAALTVGNVLPLASVPEGTVVSNVEEKPGDRGALGRTSGNYVTVIGHNPEDGKTRVKLPSGAKKVIKSSARGMIGIVAGGGRTDKPMLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIG2</accession>
    <name>A0A194XIG2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_581783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073912.1">
        <property type="nucleotide sequence ID" value="XM_018209126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIG2"/>
    <dbReference type="STRING" id="149040.A0A194XIG2"/>
    <dbReference type="GeneID" id="28818852"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581783"/>
    <dbReference type="InParanoid" id="A0A194XIG2"/>
    <dbReference type="OrthoDB" id="1432093at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="61287" checksum="B3B01F312248B724" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIJ6</accession>
    <name>A0A194XIJ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_641538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074410.1">
        <property type="nucleotide sequence ID" value="XM_018211718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIJ6"/>
    <dbReference type="FunCoup" id="A0A194XIJ6">
        <property type="interactions" value="1247"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIJ6"/>
    <dbReference type="GeneID" id="28821444"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_641538"/>
    <dbReference type="InParanoid" id="A0A194XIJ6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000023">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="382"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="581"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1203" mass="133826" checksum="116C26F6C25EC649" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ21</accession>
    <name>A0A194XJ21_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_779998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074513.1">
        <property type="nucleotide sequence ID" value="XM_018222346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ21"/>
    <dbReference type="GeneID" id="28832072"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779998"/>
    <dbReference type="InParanoid" id="A0A194XJ21"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="45145" checksum="806350C429D42AE5" modified="2016-10-05" version="1">MCLGSQLSLFKIFRHSYSILTEYEYTKFCQDQNPGADFRPYYDKADRCSKFMTNEWLAKLGDESIPGQTLSADADGLRKRRLSSLNDLQWTDIVEVWPPHPGLDKSTLPSDMKLKSGPGKLTTNPLFACVEPNLKAAERIKLLVDLSPYFTEKSQVPREKIKGGGHFIKYKIFVQLLHGEKAEYCVQFFKPGEKQLSSMPLLQSPVDLTTLYEIGSCPRRITTDGSSVDDQVEASAPKIIQQSLLESATASTQLRTEMLHQHTATSPTPTETCQDTTKLKEIAAGVHNFSIFDTVPVSPPPPGIKAAPRRGIFNNLSTTPTAPRPKNLTDLGIPGLSSSAIAGFLAPKDANAKIGQSRTVQQPENEECITVEVESEPDTAAKGRALRSKKIQVEQAEGEPLRKVRFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ97</accession>
    <name>A0A194XJ97_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_779728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074187.1">
        <property type="nucleotide sequence ID" value="XM_018222322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ97"/>
    <dbReference type="GeneID" id="28832048"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779728"/>
    <dbReference type="InParanoid" id="A0A194XJ97"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="253"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="47453" checksum="A5D36D4D4AE4E4BA" modified="2016-10-05" version="1">MESQNDIVLNDVSNFLGNNQDGDDQTLGEDLTGLNEFSLPQADGGKDAWLFLAAGFMAEFMVWGLPFSFGVFQEYYTTHEPFSSQSSGIAVIGTTATGVMYMIGLIIFPAYKQWPHLASISKWAGIPLMAAGLIGASFAQSVNHLIVTQGVLYALGGCIIYYPILMYIDEWFVQRKGLAYGIMWAGTGFGGLTIPFILNALLSKYGFRTTLRIWALALLVLALPLVHFLRPRLPISPSSQSPRYGLSFLKSSSFWLLQLGLVIESLGYFIPSIYLPLFARSLGLSPSIGTLLIALLNAAGVVATILFGMLVDRFHVTTVILLSSLGTTISVFLLWGLSTALPLLVVFSIVYGFFAGGFVSTNAGVIKLVKQGDGSADVGILLGIISAARGVGAIASGPLSDAVLRGRPWAGEAGGAYGSGYGGLIVFTGVSAAVGGVGFLGRRLGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJI0</accession>
    <name>A0A194XJI0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_439651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="151"/>
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            <end position="151"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="MFS_SpdSyn"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="21"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="589" mass="64677" checksum="53A3926E9A834F51" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
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        <property type="protein sequence ID" value="KUJ21070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216722.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194XLF2">
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    <dbReference type="GeneID" id="28826448"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694704"/>
    <dbReference type="InParanoid" id="A0A194XLF2"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CASP_C"/>
    </dbReference>
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        <property type="entry name" value="Cux_N"/>
    </dbReference>
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        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="448"/>
            <end position="709"/>
        </location>
    </feature>
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            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
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            <end position="521"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        <location>
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    <feature type="coiled-coil region" evidence="10">
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="753" mass="82965" checksum="E613FCA2BAEBB488" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM14</accession>
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        <recommendedName>
            <fullName evidence="5">Rdx family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM14"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_681731"/>
    <dbReference type="InParanoid" id="A0A194XM14"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23144" checksum="6B5B8BF6AE133110" modified="2016-10-05" version="1">MPQAVNEKPQSLELRNPSTITNTSAEMEQGPFPRVTIQFCTQCKWMLRAAYFAQELLSTFSTSLGEVALQPSTGGTFVVHLYNAVPDGSGVEGKVTIQQHLLWDRKAEGGFPETKELKRRVRDIIDPSRDLGHVDGKKSTPKPPPTTTQPTALPRAINRLQSSDSATGERKFTPMDVDVNSRPGSSGAEKVVVEEQEGTGVCRPSEDCEDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMU6</accession>
    <name>A0A194XMU6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075833.1">
        <property type="nucleotide sequence ID" value="XM_018214410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMU6"/>
    <dbReference type="GeneID" id="28824136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681969"/>
    <dbReference type="InParanoid" id="A0A194XMU6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="268" mass="29070" checksum="7F9707F504499209" modified="2016-10-05" version="1">MPLRTRRGGARDRVEDSENSKSSSSEPATPTLKSLSPGAGLTPQPRWSARIRPGDRAANASITPPTISPLSNQSLGPRSSDGEDGVEAGDIKDEDVEEGDVEDGEEADDEKSPEDTEQSSASTSSSPESEEYVESPPTQRPAKRRKIGKRTTSSSSSSSSSSSDSPVEEPIFGQLYGDRVRDPGQNRVRKVPAPSKNAKSAPQKAPQVNSGPPPPDYNKPIVFTPYFKRADFVPQPPVTGNEAWAANNVWNEESKQFEKVNLYKLRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN14</accession>
    <name>A0A194XN14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_380048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076010.1">
        <property type="nucleotide sequence ID" value="XM_018207122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN14"/>
    <dbReference type="STRING" id="149040.A0A194XN14"/>
    <dbReference type="GeneID" id="28816848"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_380048"/>
    <dbReference type="InParanoid" id="A0A194XN14"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="34136" checksum="AFA09293F91453B9" modified="2016-10-05" version="1">MGQDQVQLQVIAQSGTRSDRDNARKVLNVLQRGRHWVLVSLLLGNVITNEALPILLDQDVKGGWFAVLASTILIVVFGEIIPQSLCAKHGLAIGAWSSRYVLWVMYVLYPVAYPIAKLLDRLLGASHGLFFDRDGLKSFVMLHECLNFSTERLNKEEVTVISSMLDLNSRPVSGIMTPFAKLYTLGTNQPLDEMTRYNILNSGYSCIPVHMEHHATTFVGILQVKSLVALNLMEQITIGQLNLESMVVVRPNASCQELIHVFRDRKVKMILVTERGTPHGEPLGIVTSRDLMNELIGDPLSFKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNQ7</accession>
    <name>A0A194XNQ7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_639367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075722.1">
        <property type="nucleotide sequence ID" value="XM_018211616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNQ7"/>
    <dbReference type="FunCoup" id="A0A194XNQ7">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNQ7"/>
    <dbReference type="GeneID" id="28821342"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639367"/>
    <dbReference type="InParanoid" id="A0A194XNQ7"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16338" checksum="A401D9C5554EEF4C" modified="2016-10-05" version="1">MAVKHPLQTVKRASIPSIQPKRTQARHASLLRRPHRPYTFTQLVTLSDGSTYTCRTTSPAPVFRSTKDTRNHPLWQPSLDSLRNVEQDEAGRLRAFRERFGRGWDLDSEVGGGDEGGSLMDLISGGTYSKPGSKEMASQTKGKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT9</accession>
    <name>A0A194XNT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_681262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076255.1">
        <property type="nucleotide sequence ID" value="XM_018214246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNT9"/>
    <dbReference type="GeneID" id="28823972"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681262"/>
    <dbReference type="InParanoid" id="A0A194XNT9"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="97" mass="10799" checksum="97FDECA9F0FC6F34" modified="2016-10-05" version="1">MHTGQPGFKHREKKPELRVEYIHMGALLGYVVDILVGAVMEMDVANEMKGRVIRALNKVVWIQNDLFARHYLSKGEGSVMMPVGEGEREGGGCPFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPC5</accession>
    <name>A0A194XPC5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_715020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076371.1">
        <property type="nucleotide sequence ID" value="XM_018218172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPC5"/>
    <dbReference type="STRING" id="149040.A0A194XPC5"/>
    <dbReference type="GeneID" id="28827898"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715020"/>
    <dbReference type="InParanoid" id="A0A194XPC5"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27456" checksum="250B1CAB15CBDBA1" modified="2016-10-05" version="1">MSVKFDSTKITSSGVAAAPGGVDAMKGPAHELADEVGVALTGGKGNVGQGYLAAYLKQLQTNPLRTKMLTSGTLSALQEILASWIAKDINKQGHYFTTRVPKMAAYGAFISAPLGHVLISILQKLFAGRTSLKAKILQILVSNLVVAPIQNSVYLISMAIIAGAKTIHQVHATWKAGFMPVMKVSWISSPLALAFAQKFLPEHTWVPFFNIIGFFIGTYVNSVTKKKRLAALRKRHFDESRRPDEGYGGPGPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPF5</accession>
    <name>A0A194XPF5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_681381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076401.1">
        <property type="nucleotide sequence ID" value="XM_018214281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPF5"/>
    <dbReference type="GeneID" id="28824007"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681381"/>
    <dbReference type="InParanoid" id="A0A194XPF5"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="339"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="662" mass="75923" checksum="025EBC02CA5A2628" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ74</accession>
    <name>A0A194XQ74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_575724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076698.1">
        <property type="nucleotide sequence ID" value="XM_018208803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ74"/>
    <dbReference type="GeneID" id="28818529"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575724"/>
    <dbReference type="InParanoid" id="A0A194XQ74"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268485" evidence="1">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="30026" checksum="C87124C44D060BA4" modified="2016-10-05" version="1">MKPTVVLLGVLSLLLNASIGFSSSAPNPIGPLYPDSITGTINSTLSLVPISYDLARSIIPAQYPILTKAYHSLLPGFPIDKYPLIIRGALDHGVGVYAFNYSLADFQSIHILYPFVDLLGDGYSSFSWNKYLLISANNTIAIEGAAAGGTIVPPTTFDPDLEAYAFVPPSGHEIFLNAYTNLSTTQPAVATNFKNVTNQPIFTDGLTCDNQITLFNSSLSTGDNAPVGIRGKISIKAPYFPEEDCEAFEDVYGIKVDIAFVENPGLNCSSLKGYHATGSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQJ1</accession>
    <name>A0A194XQJ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_608651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076342.1">
        <property type="nucleotide sequence ID" value="XM_018210505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQJ1"/>
    <dbReference type="STRING" id="149040.A0A194XQJ1"/>
    <dbReference type="GeneID" id="28820231"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_608651"/>
    <dbReference type="InParanoid" id="A0A194XQJ1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044604">
        <property type="term" value="F:ABC-type phytochelatin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036249">
        <property type="term" value="P:cadmium ion import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098849">
        <property type="term" value="P:cellular detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071996">
        <property type="term" value="P:glutathione transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036246">
        <property type="term" value="P:phytochelatin 2 import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="354"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="671"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="928"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="928"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ21987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114727" checksum="011BC32591DFFE64" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQV7</accession>
    <name>A0A194XQV7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_680779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077020.1">
        <property type="nucleotide sequence ID" value="XM_018214138.1"/>
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        <property type="interactions" value="182"/>
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    <dbReference type="STRING" id="149040.A0A194XQV7"/>
    <dbReference type="GeneID" id="28823864"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680779"/>
    <dbReference type="InParanoid" id="A0A194XQV7"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="378" mass="41105" checksum="B3FD8E84AB54E12A" modified="2016-10-05" version="1">MASYYIENPNVGNKNDTEDWRIRGYNPLTPPDLLQHEIPQSAKSKETVIKGRNEAVEVVTGRDVNQRLLVVIGPCSIHDPAAALEYCDKLLALKEKYKDDLLIVMRSYLEKPRTTVGWKGLINDPDIDNSFKINKGLRTSRQLFVDLTEKGMPLASEMLDTISPQFLADLLSVGAIGARTTESQLHRELASGLSFPVGFKNGTDGTLGVSIDAIGAVRHPHHFLSVTKPGVVAIVGTVGNEDCFVILRGGTKGTNYDAESIKEAKAALAKAGVRERLMVDCSHGNSLKNHKNQPKVAAVLAEQISKGEEAIMGVMIESNINEGAQKVPKEGKAGLKYGVSITDACIGWEDTESVLEVLAKSVVQRRELLKSQKVNGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRZ1</accession>
    <name>A0A194XRZ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_728629</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076847.1">
        <property type="nucleotide sequence ID" value="XM_018219282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRZ1"/>
    <dbReference type="FunCoup" id="A0A194XRZ1">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRZ1"/>
    <dbReference type="GeneID" id="28829008"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728629"/>
    <dbReference type="InParanoid" id="A0A194XRZ1"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ22492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="552" mass="61760" checksum="885B06A9B5F66E87" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSN4</accession>
    <name>A0A194XSN4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_727977</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077563.1">
        <property type="nucleotide sequence ID" value="XM_018219218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSN4"/>
    <dbReference type="STRING" id="149040.A0A194XSN4"/>
    <dbReference type="GeneID" id="28828944"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727977"/>
    <dbReference type="InParanoid" id="A0A194XSN4"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="426"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="800"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="909"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ23208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1100" mass="123208" checksum="348BF25BB77227DC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTG9</accession>
    <name>A0A194XTG9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_663868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077791.1">
        <property type="nucleotide sequence ID" value="XM_018212732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTG9"/>
    <dbReference type="STRING" id="149040.A0A194XTG9"/>
    <dbReference type="GeneID" id="28822458"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663868"/>
    <dbReference type="InParanoid" id="A0A194XTG9"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="78474" checksum="5A25191E2A1865BB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTN2</accession>
    <name>A0A194XTN2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein required for cell viability</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_679873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077412.1">
        <property type="nucleotide sequence ID" value="XM_018213957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTN2"/>
    <dbReference type="STRING" id="149040.A0A194XTN2"/>
    <dbReference type="GeneID" id="28823683"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679873"/>
    <dbReference type="InParanoid" id="A0A194XTN2"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="552"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="822"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="99109" checksum="A5A55A2BC5366F69" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUG8</accession>
    <name>A0A194XUG8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_713833</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077707.1">
        <property type="nucleotide sequence ID" value="XM_018218080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUG8"/>
    <dbReference type="FunCoup" id="A0A194XUG8">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUG8"/>
    <dbReference type="GeneID" id="28827806"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713833"/>
    <dbReference type="InParanoid" id="A0A194XUG8"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ23352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="642" mass="70706" checksum="48BBC4D293853CD7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUI8</accession>
    <name>A0A194XUI8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_180516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28815332"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_180516"/>
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    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7730" evidence="3">
        <location>
            <begin position="79"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="37240" checksum="8051A397817F63E9" modified="2016-10-05" version="1">MGFVKMPTLAAHVSRPAKVALTVAFVALYPAICILHEAWVIQCERSYGYIRTEPKPRPITSRWRRRRALTNRDVKPPGDCSLLALPREVRDEIWRHVIGEPKVHAWISAVDSSRGLEGARCGEVCQHCSWHSVGYSTASTDKASDPTFGVMGCLLSCAQTYSEAIKLLYSMPSFDFANGSKIAYLPRVLLQQRINLIRTLNVTWRLEDPPSLPSPPRRSSDPDKMEKAKQKNHHYRETWVAVWQNLAAMEGLVDLKVELKIGSRKRRHIRHTRSHLWNASDLEIAKTVTRPRNFQLILPAELENRVREDVTAPNLRLVPSLNARGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUT6</accession>
    <name>A0A194XUT6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_712866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUT6"/>
    <dbReference type="STRING" id="149040.A0A194XUT6"/>
    <dbReference type="GeneID" id="28827733"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712866"/>
    <dbReference type="InParanoid" id="A0A194XUT6"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15175" checksum="C62417AA436A47EF" modified="2016-10-05" version="1">MPCDHYSLQVPESKFEDVVAFLLTSLKHIGFKEFYRPIPTCVGLGDGRPYLWIQAVPEGDGLGEALEILLSKHHTHMAFTAETHEQVQEFHTAALKAGGKDNGAPGLRPQFGPNYYAAFVKDPACGINFEVICRAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV03</accession>
    <name>A0A194XV03_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_726918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078219.1">
        <property type="nucleotide sequence ID" value="XM_018219103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV03"/>
    <dbReference type="STRING" id="149040.A0A194XV03"/>
    <dbReference type="GeneID" id="28828829"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726918"/>
    <dbReference type="InParanoid" id="A0A194XV03"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268692" evidence="1">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23205" checksum="822EB885BE9CF674" modified="2016-10-05" version="1">MNVLISILSLFGFLSNMTLAAYLPNGSIPPRSMGDMTISKMTFEGSIGDYKVQLNGSIQEIHAQMKAIYPDFDPDTAISNQTLDIRHLGKRSKMQPPLCYPVQDWGRAETAPINTGIRYLNQVQALCGVGANSCVRVSCSYRAAIYLCNDNDYGITPTCPYIASYAQDIINSCNYHRPGGNTWDWSVCGQEFDTDNYNVIVRWDNSDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV98</accession>
    <name>A0A194XV98_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_635992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077992.1">
        <property type="nucleotide sequence ID" value="XM_018211469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV98"/>
    <dbReference type="GeneID" id="28821195"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_635992"/>
    <dbReference type="InParanoid" id="A0A194XV98"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54664" checksum="45B5F173F5B1C7AB" modified="2016-10-05" version="1">MWREASRKDGVTASTLPTTFDIDVEKGVKHASHASYSSCETLFLEKDQPLPQKKYSRSLRHARHTFLNVYRRLFSIVFVLNLIGLGVLYGRYRESSPPAFMADLANAASANIMVVLLVRQDYVVNALFRLTWIIPLTAPLRLRRILTKVYEYGGVHSGAAISSVTWFSIFTGYLTKAFIASGPLRSPAILTLTYLLLLLLLILCITAYPRFRFSSHNTFENLHRWGGWFSLALFWAELCLFANTQVGLESLGTILIKLPAFWFLLVSSLHAIYPWLRFHKLHVRPEKLSDHAIRLHFDEKVPLFVGLRISDAPLREWHSFACIPAREGQGGSVLISNAGDWTKKTIQNPRPYYWVKGVPVTGVLCMARIFKRVVVVTTGSGIGPVLAVVQDVRDTKCRVIWSTPDPLKTYGASICNAVQNVDPNAVIIDTRKERRPDLVTKAWDLYVREKAEAVFVISNPKLTRKVVYGLESRGVPCFGPIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B347</accession>
    <name>A0A132B347_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_678409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061183.1">
        <property type="nucleotide sequence ID" value="XM_018213741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B347"/>
    <dbReference type="GeneID" id="28823467"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678409"/>
    <dbReference type="InParanoid" id="A0A132B347"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="704" mass="80733" checksum="FB7E0A6CC1F28290" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3F2</accession>
    <name>A0A132B3F2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_744053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947452">
        <property type="protein sequence ID" value="KUJ06187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060542.1">
        <property type="nucleotide sequence ID" value="XM_018221016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3F2"/>
    <dbReference type="FunCoup" id="A0A132B3F2">
        <property type="interactions" value="1087"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B3F2"/>
    <dbReference type="GeneID" id="28830742"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744053"/>
    <dbReference type="InParanoid" id="A0A132B3F2"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="20880" checksum="4B9B51C4CF028BD0" modified="2016-05-11" version="1">MRPLTEIETHTLFKKLASFAGPSLKNLIAPLDNSPQSDRFVFRLHRDRIYYVLLSHANLASSIARDKLLSLGTCLGKFTKTGRVRLHVTALPLLAEHARHKIWIRANGVMPLLYGGHVVKAHVGRWSEGCLEHQEVVFCSMDDIPLGFGVTARSSTQAKQLDPTAVVCFRQADAGEYLRDEDKLFAS</sequence>
</entry>
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    <accession>A0A132B3R8</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
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        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12739">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="781" mass="86042" checksum="7DA6565160393106" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <end position="398"/>
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            <end position="158"/>
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    <feature type="coiled-coil region" evidence="1">
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            <end position="242"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="536" mass="61464" checksum="366EBDEE2369206A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B460</accession>
    <name>A0A132B460_MOLSC</name>
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        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="547" mass="59644" checksum="7492EDC5E7208145" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4H3</accession>
    <name>A0A132B4H3_MOLSC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216437.1"/>
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    <dbReference type="GeneID" id="28826163"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691935"/>
    <dbReference type="InParanoid" id="A0A132B4H3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="68" mass="7931" checksum="0AFA831BCAAB03B8" modified="2016-05-11" version="1">MNRRCFFRSKGPDTDDHSPKFTTPCYEFTTVLPHSLVSKPSAYYWTPRPGPETPKKRPVIRPTWGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5W5</accession>
    <name>A0A132B5W5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fucose-specific lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_742502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062086.1">
        <property type="nucleotide sequence ID" value="XM_018220828.1"/>
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    <dbReference type="STRING" id="149040.A0A132B5W5"/>
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    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PLL-like beta propeller" evidence="3">
        <location>
            <begin position="208"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="467" mass="49527" checksum="E45FB3E5053EA004" modified="2016-05-11" version="1">MEVVHNTPDNEGLQVTEFHPHNEGRLALPRTSQEQDVRPSPVPSPSPYPPSYTGPLSPGLPEKPDTQPLPEIAPGASFHRRKFDISQRLFWLIIIVIVLVLGGIIGGAIGGVMASKNKGSKIPVSLGPNTQTSSIGIAASSATPTSGSTPTTTATNTISVTMPTLSVQNPTYHEKPSSQYSVFGVGLDSALWTYSTNVTSWTSMGEGITSSPAVSHQIWNGNSWSSWTSLGDGLLSPPAVTARGPGLMKIYVVGTDSALYVMWCTSGTWSTWWGLGGVLKSPVAVVSWTSSRNDVFGIGTDNAMWHISWDANANPEWSNWESLGGVFISEPMVVTRGSQELDVFGVGSDGGAWYRYYGNGSWSENWVSLGGIFVSSIVAVVSGTDQVDIFGLGLDAGIYTKQLSGSTWSSSWTALGGISNSAPEVITTGDNSIAVFVLGLDTTVWTISRNSGVWTTWVSLGGLFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Y3</accession>
    <name>A0A132B6Y3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_765574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062456.1">
        <property type="nucleotide sequence ID" value="XM_018221678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Y3"/>
    <dbReference type="GeneID" id="28831404"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765574"/>
    <dbReference type="InParanoid" id="A0A132B6Y3"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="1">
        <location>
            <begin position="271"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="431" mass="48724" checksum="64B2ED5FB02B0F78" modified="2016-05-11" version="1">MAAIQELEDLEKVDESLPRIPEDITLRTLSTLNVDHLKQRLSDAGVKHQAKILKAELQALWAFHTMRILGFYEKPQEAELFVKTVRWFKIPVSQVLVDVKSAGLGKCANKWDYIEALIRDGYTPPDPKLETKVVVQYRGVVEDALAELDISNAASTPHYSVVNLLLSTVYSDVANDGTFSSVDLVLPGCTFPRDDLLKHINQLPLMTSAHHLRESLKVPRSPEFDLLGWLCTELGHIICPAEGNLKIAGLPESAHQFILEKPAQTKLDSFEKNFKQHYDNSILLFHGTCLKNLRSILRCGFQPARDRRFGAGLFMADQPFGSSYYAQHQSQAGRNLSHEWTNDLYTNYGMLLCCEVTGNGRFAEHEGAGLDRYDVHVIKRLDSIMIRHIVLLPYAEMYKQCIEVKLRRSMVEGDMLKAFKSIRAKQIGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B759</accession>
    <name>A0A132B759_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_338878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062603.1">
        <property type="nucleotide sequence ID" value="XM_018206847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B759"/>
    <dbReference type="FunCoup" id="A0A132B759">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B759"/>
    <dbReference type="GeneID" id="28816573"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_338878"/>
    <dbReference type="InParanoid" id="A0A132B759"/>
    <dbReference type="OrthoDB" id="3886144at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF47">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="812" mass="90924" checksum="E088C8E25CAB06E2" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7E2</accession>
    <name>A0A132B7E2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062149.1">
        <property type="nucleotide sequence ID" value="XM_018216339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7E2"/>
    <dbReference type="GeneID" id="28826065"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691498"/>
    <dbReference type="InParanoid" id="A0A132B7E2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25779" checksum="7847D9640C7C334C" modified="2016-05-11" version="1">MAANIVSRFYRTNLLRPVACPKTLLKTNSPANGQQTTRTVSRTHDGIGKKLIFVKDAKASLGVERTKRSDFKDNGPSAKAPSTEKSKQIASIKQVNATNPNIRVIELPKDKTGDRLMAAAREFWLQRVPGVDPEMRMFPLELRKRIRNGTQSLHLEVDLKGAWNEFRPNGIRFAADEKLGQMLCRASGIDIADGKEEEGAERQRLFAGLIVTGFLGYVEYHRRTRNEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B837</accession>
    <name>A0A132B837_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_676833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062768.1">
        <property type="nucleotide sequence ID" value="XM_018213633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B837"/>
    <dbReference type="GeneID" id="28823359"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676833"/>
    <dbReference type="InParanoid" id="A0A132B837"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="335" mass="37844" checksum="C1A5EBA9DEBF1575" modified="2016-05-11" version="1">MAPLTLPSKKLDRAYEAVVKPIRNSPHQFPNEFPAKVTDTDEDREEYLKMSFFYHMNRPHTPHRPQLSYPEVILRLKDVLEEVLNQERGYKMAISTLDGSDEESSDVDEEEELEDEEGGNRDDEAMVEDIEEHQDHKDLVPDGSEGDESDHDENSSGSEVEEDENDESYENSIVDEATMVEDDEEHQEDEEVGNNKTGNNDRNSSIGESSMGAGRKDKNRKAKGGPNKVNNIKKGNSLRPKPDGVPALVKRFTSSLEEAAKALGITKKAAAARAVNLATFPHCTKCKGRKVGCNRRLWGHCQNCRNDEQCKPELERYRTARGIFGQMSKEMVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B878</accession>
    <name>A0A132B878_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062926.1">
        <property type="nucleotide sequence ID" value="XM_018216208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B878"/>
    <dbReference type="GeneID" id="28825934"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691004"/>
    <dbReference type="InParanoid" id="A0A132B878"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="61" mass="6920" checksum="75D502794C400114" modified="2016-05-11" version="1">MASQSTLRHSADPIANLYQQYMKLFRDRLKGTRIGLSLCCPCSLCFIKGQMSVPPRSAQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8J0</accession>
    <name>A0A132B8J0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_677179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062664.1">
        <property type="nucleotide sequence ID" value="XM_018213663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8J0"/>
    <dbReference type="GeneID" id="28823389"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677179"/>
    <dbReference type="InParanoid" id="A0A132B8J0"/>
    <dbReference type="OrthoDB" id="2421200at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="20979" checksum="2EDC879FE95495CF" modified="2016-05-11" version="1">MSTPSLFDGVVNSNGILMIAFGPIFLAFIPVTNYITTPNSLVQKAIETLLAAIPGSASIPSNRVIPALSAFYIFWTFAATGAASAAGLGASRKEGLDNSHPRKDISALRGLPLRLRSAHYNTMEMFPIKGFALAAALAQITAPTNQNLINLLGLHVLLKTFIYYPAYILDIAPLRSLAHLGATASVINVAWQVATGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8R4</accession>
    <name>A0A132B8R4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_659768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062412.1">
        <property type="nucleotide sequence ID" value="XM_018212525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8R4"/>
    <dbReference type="FunCoup" id="A0A132B8R4">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8R4"/>
    <dbReference type="GeneID" id="28822251"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659768"/>
    <dbReference type="InParanoid" id="A0A132B8R4"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="23610" checksum="E40D30DC6C996826" modified="2016-05-11" version="1">MFKKDISPGSKSKVKSSVQRAIRTQLVQTYPLLAPHIDEIIPKKEQLDAMKIPERVTLYLIGLTPLFYQHMTDALLPHLKLVHRFPTCFPSLRIDRGAIRFVLSGATLMAPGLTSTGGRLPTGADTEKGGYGELGGKGEEGKLYWDGEGEREGEGWYGGRELEKGEPVVVCAEGKLEACAVGLLSMGTKECKEKGKGPVVEEGHYLGDGLWRLVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B989</accession>
    <name>A0A132B989_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_316672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_316672"/>
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    <dbReference type="OrthoDB" id="771136at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="437"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="683" mass="70636" checksum="B907F9DB156C95C4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9C5</accession>
    <name>A0A132B9C5_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="93" mass="9646" checksum="11E8759F0F595C60" modified="2016-05-11" version="1">MSSTAVFNQTGNAAYSPSEDSSTRNKSLATNFQNAGLPSSDSLRAPAGGLLKGATDEHGNLKPAALMVGIKLDLEAEVHLTARVRGDITVGLY</sequence>
</entry>
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    <accession>A0A132B9D4</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="630" mass="69216" checksum="079F6EDB8DA2E56C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9D6</accession>
    <name>A0A132B9D6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9D6"/>
    <dbReference type="GeneID" id="28823304"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="51662" checksum="916EF2241716AF91" modified="2016-05-11" version="1">MEHRDREMANNSKTDMDNIHSFVRQQFAELEDSLKEEIRSVPEAVWKTAKMTDAGEAARNTFTNLFGLFHRQTDEGDSKAKTQLEVSAHANHELEVERKAILRDSEDWRSGFEKSAEHYQNKLKEEIADIRFQKDKAVRRLKDAERENGELQKQVATFRSIIIKHGGSESGQLDDATIVARFVNLRTKIRGIVMRDCHFDKLDTATGHESLQKLHKRGLTIFDLKNQLQESLFREVCRVFFSVLAFGLEGSTLGDQVNYGLGRFEWELLSLSPGQGYQKDSLEWRLLTIKCAKLLGQPNPDVAAQRILDWLQPFLGMTEKPDQDTPSDSSSKLNRESTSKSTSESRVKQLCQDALDFALLIRTCRDRYQAERTIEREERSEQAWEGEMGSDNDPREIACMISPALVKYPGHDWKKRLVLEKSHVIVRKIVPGGCNELGVGSLLPHDCDRAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9I1</accession>
    <name>A0A132B9I1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_676796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063268.1">
        <property type="nucleotide sequence ID" value="XM_018213625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9I1"/>
    <dbReference type="GeneID" id="28823351"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676796"/>
    <dbReference type="InParanoid" id="A0A132B9I1"/>
    <dbReference type="OrthoDB" id="3526573at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="1">
        <location>
            <begin position="751"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="873" mass="88987" checksum="909D2113D1792593" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Y3</accession>
    <name>A0A132B9Y3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_788610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063029.1">
        <property type="nucleotide sequence ID" value="XM_018223182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Y3"/>
    <dbReference type="GeneID" id="28832908"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788610"/>
    <dbReference type="InParanoid" id="A0A132B9Y3"/>
    <dbReference type="OrthoDB" id="4757168at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="649" mass="75497" checksum="446EC38416E62DD5" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCU5</accession>
    <name>A0A132BCU5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_723874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064428.1">
        <property type="nucleotide sequence ID" value="XM_018218852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCU5"/>
    <dbReference type="GeneID" id="28828578"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723874"/>
    <dbReference type="InParanoid" id="A0A132BCU5"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="38394" checksum="AD515416204BEF5B" modified="2016-05-11" version="1">MTSLLSLPRELRDQIFDIFVAARNERPKDIESIQTRQYTYTEHILNQVKVDCIHHNRRNIGLVSLLLANKQLNAETKDAFERFEGRGKYELDIFVTGEREFWPTWIYLPKRTNIMEELHITFRVFEGEDFWLRASGSKPINYIGGWAFFHLLERLLKEGPRAVCAHGSSKHSSTITERTLSWAEALRGKAPALDQSLRIRKLYLHFETGFEGDFKEYIGMDCLRLDEMQRLGSRSKGTDCKTPGGRLAAAFSTEITDIMQNRWADLETWLDRIGSIWSHFDDRPLFSYDFAKRLSELAVLNGRGHPEIDPLYRSRVKFGLGVIKLGQFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCW3</accession>
    <name>A0A132BCW3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_710643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064625.1">
        <property type="nucleotide sequence ID" value="XM_018217846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCW3"/>
    <dbReference type="GeneID" id="28827572"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710643"/>
    <dbReference type="InParanoid" id="A0A132BCW3"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="183" mass="19840" checksum="F6DC53782B7CC97E" modified="2016-05-11" version="1">MTPKKTKVSMPGVAEGKELIGISIDDDVSSEDRVKGLFFDSLSEDIYQGWAASMFRSDLKLLSASKNPGKTVFRYVVKPEHCNRLGNLHGGCTSTIFDAATTTALAPIAEPGFWVYAGVSRTLNVTYIRPIPAGEAVLVESEVVHAGKRLCSLKGVMRRERDGAIMATCEHGKVSIDPEIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDA1</accession>
    <name>A0A132BDA1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_787441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064760.1">
        <property type="nucleotide sequence ID" value="XM_018223074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDA1"/>
    <dbReference type="GeneID" id="28832800"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787441"/>
    <dbReference type="InParanoid" id="A0A132BDA1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26363" checksum="39249EB79E5522F9" modified="2016-05-11" version="1">MSKPKSTEPFPYTYSSLDEEQQIREPDLPKTRLKWILTCLLSTILGALVAYGVTHYRFRFDVRLDIHSKGVFHEISLIEVPWYSDKRYTTSDPSDPNGSVWDGLDPMGQGWIEVPNWEELGLHPSEKISHYQVSMYHQLHCVAILKSKFLYVDSVLEGDGQSEKTDYISHVHITHCLEYLRQAIMCAGDTTLEPFTPDLGLDISHKCRDWDAIFDFATIHRSTNNTGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDI6</accession>
    <name>A0A132BDI6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064803.1">
        <property type="nucleotide sequence ID" value="XM_018220553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDI6"/>
    <dbReference type="STRING" id="149040.A0A132BDI6"/>
    <dbReference type="GeneID" id="28830279"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740160"/>
    <dbReference type="InParanoid" id="A0A132BDI6"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="768" mass="87265" checksum="2B8F365FE4CE4C1B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDP1</accession>
    <name>A0A132BDP1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_723718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064895.1">
        <property type="nucleotide sequence ID" value="XM_018218841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDP1"/>
    <dbReference type="GeneID" id="28828567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723718"/>
    <dbReference type="InParanoid" id="A0A132BDP1"/>
    <dbReference type="OrthoDB" id="3518210at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="16462" checksum="51F2CC2E23CCE9EC" modified="2016-05-11" version="1">MADISKTSESKNPAKVPTDGSFHSGVWDYEAKRPVVDGKFEDPLTGELRDAKSEQYSGPPSVDIVIMNLYASEASGPDVYRSARPFPVERILHHAMTVVKEEGLEIHCLNASLYSVTLVLACEIEERKDGRSGFSYVADRISNGLWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDX8</accession>
    <name>A0A132BDX8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_689692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064808.1">
        <property type="nucleotide sequence ID" value="XM_018215951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDX8"/>
    <dbReference type="GeneID" id="28825677"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689692"/>
    <dbReference type="InParanoid" id="A0A132BDX8"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5672" evidence="2">
        <location>
            <begin position="118"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="34738" checksum="AA1D98EC9F583AA7" modified="2016-05-11" version="1">MERLLASIKSRPIWRIGTLTLAFCIATWFLISLNPRNVLAEEKTNILPDTTSSANTYGLIRNKVAVISDTKYTTNLIPLILHYHSILGPSWPIIFYTTPTTLPSSLSAPFALAIAEKRIQIRYIPDEFNLTSRNGVNLYLSRSWLWEQLAPATHVLIFQADAVLCGNAHKTVDQYVDEGWDWIAAPLHGSEHLYNGGLSLRNRSMILDILSNPENNWEEETRSGKWTMGGEDVWFSRKMDLRGAKLPSFREAVAFACQHDWHTSVEKEPLGYHKVHKNIGKEGLREIERWCPEIGLARPGMLEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE50</accession>
    <name>A0A132BE50_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_675136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064634.1">
        <property type="nucleotide sequence ID" value="XM_018213486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE50"/>
    <dbReference type="GeneID" id="28823212"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675136"/>
    <dbReference type="InParanoid" id="A0A132BE50"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288162" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="161" mass="18552" checksum="A48523CE2C1F7298" modified="2016-05-11" version="1">MIRGWVSLFYLSQLTPSWIGPRCCVTGIALLSVVTSDKLEVSRDRLRSMESVDVWSGGCLVQRKKIIGVDVNHWMGLDQSTRELSEYCMRGDDYLQRMYHQSNQENRAAETPKHQAQRHWTGNFAADPGHISGSVQYERMPTKYRLHIAMSEEGFEKIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE77</accession>
    <name>A0A132BE77_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_263864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064908.1">
        <property type="nucleotide sequence ID" value="XM_018206297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE77"/>
    <dbReference type="STRING" id="149040.A0A132BE77"/>
    <dbReference type="GeneID" id="28816023"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_263864"/>
    <dbReference type="InParanoid" id="A0A132BE77"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65903" checksum="7874CD6149A3C388" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT02</accession>
    <name>A0A194WT02_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_739303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065445.1">
        <property type="nucleotide sequence ID" value="XM_018220450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT02"/>
    <dbReference type="GeneID" id="28830176"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739303"/>
    <dbReference type="InParanoid" id="A0A194WT02"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59715" checksum="FF06ACE31288440B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT32</accession>
    <name>A0A194WT32_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_250584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065132.1">
        <property type="nucleotide sequence ID" value="XM_018206191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT32"/>
    <dbReference type="STRING" id="149040.A0A194WT32"/>
    <dbReference type="GeneID" id="28815917"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_250584"/>
    <dbReference type="InParanoid" id="A0A194WT32"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000222">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="50761" checksum="8872467C128487A1" modified="2016-10-05" version="1">MSRTQKPQDLKVTLAEQIDSSFAYETIRVLQGPHKVLDISLRRTIRVPDNDQAYLLPPDCGAFPIYSVNRFKHQLPNDMAEKGGLFIPMYEREAMWINFESIQPFAVKISVGGINAVSGDSATDALSASRLRERQQKGTLQDYVVTGRNMQQWLDGIAAEEGKVKQFIATPVGSGYSVEAQLTGADNVAGLQFEVMALKKMDAITIYVKTLTGRTISLTVDLTMTVDDVKCLIQDKEGIPPDQQRLIFEGSQLQDECVLASLGIESDCVLHLVLRLRGGFIYEQLSLVEKAKYDRDQHEKRSAAAEEERRVSEMTIAAGGTIHQAIVKDKISDSHWDKHSTISFNLQILNAANFHSLLGISAPNTPISAATYAEYGYPFFKLYEDKSGIKGNFEGVKSVGQLRKDAGTHNPDEDFYYGFPIVSLNAPTSKKPFVILSDLEARLRDIMNDAVIWFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTQ9</accession>
    <name>A0A194WTQ9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_786952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223031.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28832757"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786952"/>
    <dbReference type="InParanoid" id="A0A194WTQ9"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="491" mass="55080" checksum="23639893BEBA8727" modified="2016-10-05" version="1">MARLGVGKSGGCRNCRRRKVKCDEHRPGCKRCEKSNQECEGYTREHRFVDENFRTEKHVKKKASTETPQPDPRSSQDIILHSNSSSGLTAMNLEIHAFQDNIFMSFLLSNLFSGIPVVTPWLRLHAEDTSSASAQLSTRALSTVFFGRTHYQHNITARGYNLYGQALISLNQDLQDSKKGQSLSVVKTAMALELYEFIASNTSGWIKHAGGVGRLLELRGPQLHQSPQGREIFEASRAIIALGYLVKRKRCFLESTEWKTIPWALEPEAKTSVMFLHDIACDLPGVMEDVDQLQSPQMSPEEFIKHHAFVSGRITSCLKELYGWRASWQRQNPHACWEVLSTDSTTGSILFPLVFNYKSLIEANALTFYNALLLLLLKVASQVIGPQFDPSTCAAHLPRGLRYEPLIPPGLAPNAQAIAYEICKSVEYLLGAERRRAGAFFLLFPLRVAWQAFNPVDMEAVWLQGIMRIIADSTGFEVSRGLMGEVVQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU07</accession>
    <name>A0A194WU07_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_225619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065791.1">
        <property type="nucleotide sequence ID" value="XM_018205985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU07"/>
    <dbReference type="GeneID" id="28815711"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_225619"/>
    <dbReference type="InParanoid" id="A0A194WU07"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR VIB-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="117"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="117"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="596" mass="65252" checksum="FF793B40FD6CA568" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWK8</accession>
    <name>A0A194WWK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_205961</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28815546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_205961"/>
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    <dbReference type="OrthoDB" id="3562394at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012227123" evidence="1">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="32500" checksum="8D30DEFCF0E6A0D6" modified="2016-10-05" version="1">MRSLHILSCATAVSAFNLFGDLFQRQQPNCTVYTVVEYPCAVQTFLPSNTVVWVDACSTTLNITNAPTSLKTTITSTTTIGLPKTSTSTVVVSLKTTATIFHTLTLPGPAQPTTTSSTAPVITGTNSGCVPSSTSYPSAPNIPANTTYVISVTSPEIIAHLGNSPVYLTREGGVVDNTNLAVEVFFYDGVLFALDTAFGVGWYGMELSEATMPFALEQYSSSSQSIARTFTTVGSSPPTLAWNNCQFQNENVTWTLNESDGVVSAWFSDSDSNSFGLKPKCTNGYGCSCLVLHSAFDDWICSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWQ3</accession>
    <name>A0A194WWQ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673387</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWQ3"/>
    <dbReference type="GeneID" id="28823083"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673387"/>
    <dbReference type="InParanoid" id="A0A194WWQ3"/>
    <dbReference type="OrthoDB" id="3562788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112390" checksum="B93CA63DC7F35FE1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX10</accession>
    <name>A0A194WX10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066871.1">
        <property type="nucleotide sequence ID" value="XM_018218707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX10"/>
    <dbReference type="GeneID" id="28828433"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722114"/>
    <dbReference type="InParanoid" id="A0A194WX10"/>
    <dbReference type="OrthoDB" id="10595090at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="31610" checksum="AD4A306FDD7CB3B7" modified="2016-10-05" version="1">MRSFRVPDTFLYTHRMLSEFFRGTPSFSLDMISNELRLHITHFLTQNIPLYPFPNAQHGNHPPTPRGTIIIPLCQHTALFHPGSPHWAAYQQLIPALRSTVTSLSTWFCADQPDVYASAKRYLVNLGNGSNIIPGMTGANDMNCFLTMRLSVNTRNAPARLMTSHESPWTAVTFVGDYVGGKIKSPLLDDIGLMGRVLGVPDDVLFVVDWIPIGQSAFTGTRYQLELFVPPVGEKGEGVEEPSAEEKGRPKREDKGDRYDDGEVGGSKAQSVVPPWVAHVLAHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX42</accession>
    <name>A0A194WX42_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_623741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066911.1">
        <property type="nucleotide sequence ID" value="XM_018211031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX42"/>
    <dbReference type="STRING" id="149040.A0A194WX42"/>
    <dbReference type="GeneID" id="28820757"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_623741"/>
    <dbReference type="InParanoid" id="A0A194WX42"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="405"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="693"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="90618" checksum="F3F969131881C22C" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX88</accession>
    <name>A0A194WX88_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_209769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066895.1">
        <property type="nucleotide sequence ID" value="XM_018205858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX88"/>
    <dbReference type="STRING" id="149040.A0A194WX88"/>
    <dbReference type="GeneID" id="28815584"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209769"/>
    <dbReference type="InParanoid" id="A0A194WX88"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="543" mass="61459" checksum="6F28A5AE65267D2E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYS2</accession>
    <name>A0A194WYS2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_592412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23658">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="112"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="673" mass="73645" checksum="D32CC37E2FE855A0" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <end position="65"/>
        </location>
    </feature>
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            <begin position="53"/>
            <end position="64"/>
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    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KUJ13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="156" mass="17562" checksum="6D94E79F61527D2A" modified="2016-10-05" version="1">MGLEYCTKTGRQLQLISGNHHSLTYSRAKADHVFSSLGKRALKDRDQGLQHAASKTGQRTNVGSRGQHHVKHYTVFLHNSHSNPTHGLGFRSNRQFALIQNNLEIPKQRLVTNALSSTAHHVAVWCRCRTPKTFQTFYLPSSTSTQPEWGRSKCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0D2</accession>
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    </gene>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="entry name" value="Appressorial_penetr-assoc"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
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        </location>
    </feature>
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            <end position="336"/>
        </location>
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        </location>
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            <end position="326"/>
        </location>
    </feature>
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            <begin position="327"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="33068" checksum="B748849CFA682E1A" modified="2016-10-05" version="1">MLLQKTIIALTLALACESSIIPEVGYGLVARQNGFGGNNNAANNGGNKGGNGGNNGAAAAASAAAAKASASAAASKANNGGGNGGNNNAAAAATCLNAKAVQTGSASDGNQTPADGQAASATDTANFINFCSGQTLTNGLQVKQGSCNGIVMGKIPSTANMISGIITSPKPGENIAANKDFTISIQTKGLTAGSFTNAAATYYSAPQDLASNGQVIGHTHLTVQDLGNSLQPTTAPDPTAFVFFKGVNDAGNNKGLLSATVTGGLPAGNYRVCSMTSSSNHQPVLMPVAQRGAQDDCQKFTVGAAAGGNTNGNAANANNGGNAKTGGKAKSRRFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1C8</accession>
    <name>A0A194X1C8_MOLSC</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
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    </dbReference>
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        <location>
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            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="171"/>
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        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <begin position="324"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1K3"/>
    <dbReference type="GeneID" id="28825200"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687335"/>
    <dbReference type="InParanoid" id="A0A194X1K3"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="15699" checksum="B56C1F1520F53569" modified="2016-10-05" version="1">MQLPTPNTRMNDGVSEAPPPKTINPIPHLKYIFSLRCKIDPAMNVGEGPYGFRAHVPITGGTFSGRFGMNGKVLNGGADDMIVVDEIRTRIDTRYMLETDDGALIYIRHVQTSHIIPQKPNILTNILVQEEEEQERQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X207</accession>
    <name>A0A194X207_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_152017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068379.1">
        <property type="nucleotide sequence ID" value="XM_018205404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X207"/>
    <dbReference type="GeneID" id="28815130"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_152017"/>
    <dbReference type="InParanoid" id="A0A194X207"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="431" mass="48419" checksum="F9D06B3AE6EBF09A" modified="2016-10-05" version="1">MAPRLEDCPNEVIESIVVLLDLNDICNLRQTSRSLATKATQNHFKSFYLSKHVDTTTRSLEKFVDATRPGRLGCLVQNLTIFGVFTFPRVDGRDLAAGLWATGMKLDLLNQALSGIAAAKRTEETISLSRNGVDWESYWQCVAGTFHTAMRAVAASGLKLRALIVFHDTGGQSGNLGCDELNRLDFQDQRLVASLSSLKYLALSLSDRAITNLPEPDRSQPPKQEFILEAMGKATDQENFIGLEKLLQLAPLLEDLEIRYYRLNAAHVFLRSPYLQHELLLRELAQSEKLPRLKTCSIRGIVISSEDLLAFVRRTAPQRLLLDNVILSGGIFTPFFDHCTGETTGILEFEFKELFEKHNIVHFGEPGQGSFAQGLQQTGTNSSRTSTSLIRTGDGVKKPISYHYYHGVPMDTPQIREERRERQRLYGPLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X247</accession>
    <name>A0A194X247_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_736325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068635.1">
        <property type="nucleotide sequence ID" value="XM_018220112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X247"/>
    <dbReference type="STRING" id="149040.A0A194X247"/>
    <dbReference type="GeneID" id="28829838"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736325"/>
    <dbReference type="InParanoid" id="A0A194X247"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13475" checksum="712FA15E7ED2F676" modified="2016-10-05" version="1">MPPSINPLDKFPGKDKDAYEAVHPLVRTNPVTGWKSLFTGVNSPRDGWINGVTERENEILKDYFKQLFVENHDLQVRNRWGKDDIAIWDDRSVDHVATNDYFGKRTAYRVSSVGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2F9</accession>
    <name>A0A194X2F9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_137123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068731.1">
        <property type="nucleotide sequence ID" value="XM_018205285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2F9"/>
    <dbReference type="GeneID" id="28815011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_137123"/>
    <dbReference type="InParanoid" id="A0A194X2F9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="282" mass="30889" checksum="C1A97B77235DCB0B" modified="2016-10-05" version="1">MQGYIWQRCEVHLTSKLLRKSRHPTSQEGLSISSSVVAGNFLNAASYFAQMATTIDTSVAHYETIVCIPGDVVVVESGILGDVKLQLAVGAVKSRDLYRDGSGPFACSPAANEKLPSPHFTSPTSKENFQQIRRLEVQSSPINLSILSPPHQTVNHLLLPAFPLKPRKHISFHSGPRRRSFSLPPCSHDLGRRSSLFRSQPPLPHHPCTYLLAPSQTAWQSAKSHGRPDSTMLSCNHLHSIAATRFCCPGNYLSHTKSGYGGTTHLTSSSVPVCICFTLHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X396</accession>
    <name>A0A194X396_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_588723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069030.1">
        <property type="nucleotide sequence ID" value="XM_018209496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X396"/>
    <dbReference type="STRING" id="149040.A0A194X396"/>
    <dbReference type="GeneID" id="28819222"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588723"/>
    <dbReference type="InParanoid" id="A0A194X396"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13553" checksum="FF763F914245D9C9" modified="2016-10-05" version="1">MAFFWKPGTQEIRLALLQPGIWDDEISYHLTNSSLESPIAYESLSYVWAQETGHNSIKLNGKEHRITNNLFKALKRLRKAREARCLWIDAICIDQDSILEKNHQVALMGAIYRPRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X416</accession>
    <name>A0A194X416_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_124993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069283.1">
        <property type="nucleotide sequence ID" value="XM_018205191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X416"/>
    <dbReference type="GeneID" id="28814917"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_124993"/>
    <dbReference type="InParanoid" id="A0A194X416"/>
    <dbReference type="OrthoDB" id="3558251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="25635" checksum="DCA8A29AA5C463EA" modified="2016-10-05" version="1">MATTQSSQPVQGDNLQTPKTPSTPYRDDFNLTPNTNTTTSFADSGFFSSPTGDPCHGTGYKDWVLFPSDEGEEDGSFGDGSGFLDTRGFFRDADECVMIDYESDVHHEEEYSQNPTTTASSSLTLDSHAPYSPHTELVKALENHHISSSPPPKSPKLPRSKDSEDEESETSMLQIWQQRSERHELLSYKFEQPPYTSREHLLPVFRQSSRVRKNGAVRPSQRKSVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X469</accession>
    <name>A0A194X469_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_123913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069209.1">
        <property type="nucleotide sequence ID" value="XM_018205180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X469"/>
    <dbReference type="STRING" id="149040.A0A194X469"/>
    <dbReference type="GeneID" id="28814906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_123913"/>
    <dbReference type="InParanoid" id="A0A194X469"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="374" mass="41512" checksum="A85A5FCE0E7451A6" modified="2016-10-05" version="1">MQVTSPEGGTCQMTSSGEEDTSRDYGVYDLKFLPYHPIFAAATTLGKILICQLEEIGEPEQKDLQIKEVSSHQVIPENITICSVAWFPLQHASDGTRILAFTVEDGRVFLVRFRDDFKSFDFLNGQLPVHQHFDKTPVSNNAERAWCCAFSRPRPDSVMSGGDDSVLRRSTLNFPQDLTTLQEDSSLWSVVTDLALYREKRFPQGVTAILPFPFCTPECSSTIFLVGCYDSSVGLWSVYGKDVPEAEVNLGGGVYRLKFLQYEPGPPEQVACTFQVLASCMDAGTKILEVKRSISGHWFIDVVAEVKDHQDLCYAADVQPLPAPGDGEAPITCLEERICVSSSFKDCKLSVWKFNPLHVVRGGIILPLHSPMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X566</accession>
    <name>A0A194X566_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_648570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069680.1">
        <property type="nucleotide sequence ID" value="XM_018212022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X566"/>
    <dbReference type="FunCoup" id="A0A194X566">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X566"/>
    <dbReference type="GeneID" id="28821748"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648570"/>
    <dbReference type="InParanoid" id="A0A194X566"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="48167" checksum="86A6E3F0A7E93988" modified="2016-10-05" version="1">MVRNIVVLGGNSHPQLVDTISNILGVPPCNRILSKFSVGESRLEIKDSVRGKDVYIIQSGGGKVNDNFVDLCIMISACKTGSAKRVTAVLPLFPYSRQPDLPYNKVGAPLSKAPTDVNRGDFTFESRPPTPGPGQPQSQSLTNGNGNGMEGLQKKLGKASLEQQNGTTYTNGITPPRRSDTLDSSSSVTGRGRGSSSSSASAPPFTTHDYENPTMLKEAGKIFQAKPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGKALLKRYIQTKIPDFKDAVIVSPDAGGAKRATAIADDLNVDFALIHKERRPTRITDRQNATMMLVGEVAGKVTILVDDLADTSNTITRAAKLLKKEGATKVYALLTHGVFSGDAIARINASALDKVVVTNSVPQDEHKRLCPKLEVLEVGTVFAEAIRRVHHGESISALFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X584</accession>
    <name>A0A194X584_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_540000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069322.1">
        <property type="nucleotide sequence ID" value="XM_018208153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X584"/>
    <dbReference type="STRING" id="149040.A0A194X584"/>
    <dbReference type="GeneID" id="28817879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_540000"/>
    <dbReference type="InParanoid" id="A0A194X584"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26168" checksum="88248B5F08FBA4BE" modified="2016-10-05" version="1" fragment="single">MSFGYSIGDFIILTQIAYNTVQNALKACGVHDKLTREVNSLRLVLNRLQVEVSKPDSILNQKEDNRRKELATLAGDCRRVLNILTQILEKYNALSDEKRSVTKLWQRFRFGSGESQDLGKIRGEVSSYTQAISLFLNMLAIGSQGKVEAYMDAHGEELRDIKQSLHWVTASLQARGTHEEKSILTTYPDDDKLVWKAFRKELIMEGFSSRTLGRHKKVIKKYVLEMGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5N0</accession>
    <name>A0A194X5N0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_735591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069840.1">
        <property type="nucleotide sequence ID" value="XM_018220033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5N0"/>
    <dbReference type="GeneID" id="28829759"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735591"/>
    <dbReference type="InParanoid" id="A0A194X5N0"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="285" mass="32906" checksum="10CACC8DD86959FC" modified="2016-10-05" version="1">MAPPEDLSVKAPIYFLSRNPIYETTKPYTLRYRPSEASQIPQTNVERELHELVFHDLRLAHGLEYETCGFQVVSLESEMKYEEYDDEEKVERFHGKEVGEAVRVALGARGVDVVDYVIRRRDPSWPIATGETYRSQQPASAAHIDHTYEEGCRIVRDIYGEKADVVLQGRWQCVNVWHPLQGPLVDWPLAVCDASTVDFDNDTMAGDVVDREAVFENTQVHFNFDQKWYYLPYQLPSELLIFKNADSEEKDGSTQGSPHASFDNPRTTDADLRRESVEFRILVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X725</accession>
    <name>A0A194X725_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_749542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069962.1">
        <property type="nucleotide sequence ID" value="XM_018221176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X725"/>
    <dbReference type="GeneID" id="28830902"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_749542"/>
    <dbReference type="InParanoid" id="A0A194X725"/>
    <dbReference type="OrthoDB" id="10690655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="614" mass="71759" checksum="5F36A1A58635F6FE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X774</accession>
    <name>A0A194X774_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_735167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070378.1">
        <property type="nucleotide sequence ID" value="XM_018219982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X774"/>
    <dbReference type="GeneID" id="28829708"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735167"/>
    <dbReference type="InParanoid" id="A0A194X774"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="236" mass="26216" checksum="8BF9A92F72F6914F" modified="2016-10-05" version="1">MEALQLKVALRILGHAGIPTCLVGELALNYYNVPRVLHDIEICVPENMVLKAASLLRGTGLFEPDEIEEFDLYNEYKRGCPRLRSSSWISPSSALVILGDKIYGLNPISKNVLSRDKVPSNPSYSSQIMDLIPPAEINQLPIPRLPVLLVGLCRRFLESHDDVAMIAAEQLVDGMDLDDGWCDRNLSGVSSAVLEMSSRLVAGKTSRLDDFSENTITCFIANEDEVERVRRIPGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7N6</accession>
    <name>A0A194X7N6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1681-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_718952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070535.1">
        <property type="nucleotide sequence ID" value="XM_018218457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7N6"/>
    <dbReference type="STRING" id="149040.A0A194X7N6"/>
    <dbReference type="GeneID" id="28828183"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718952"/>
    <dbReference type="InParanoid" id="A0A194X7N6"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000465">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="28666" checksum="5536023AF6A8DDEB" modified="2016-10-05" version="1">MEPSIDPATGRPLPADAIQRILFIAASVHVYNIPPLTSTKGYVAASWTADNNKRQIFTARLRILETAVPTATGETLKTDILLEDPSNGQLFAAAPYTNASIVEQVLDSSRFFAVRVEGEGGRKAVLGVGFEERSEAFDFGVALQEVRKTLGLEDNGKAGGKKPVKEEKKEEKRDFSLKEGETITVNIGGRAGRRNPPKEKEESHQSLGSFSLPPPPGGGSLGSFLPPPPSASELKAQKRLSQTFEPPNPNTIGDMGFDDGEFGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7T9</accession>
    <name>A0A194X7T9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_586522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070585.1">
        <property type="nucleotide sequence ID" value="XM_018209372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7T9"/>
    <dbReference type="FunCoup" id="A0A194X7T9">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7T9"/>
    <dbReference type="GeneID" id="28819098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586522"/>
    <dbReference type="InParanoid" id="A0A194X7T9"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1172"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1201"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1211"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1273" mass="142300" checksum="F37009AFD4356A94" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X828</accession>
    <name>A0A194X828_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_719065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070675.1">
        <property type="nucleotide sequence ID" value="XM_018218465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X828"/>
    <dbReference type="GeneID" id="28828191"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719065"/>
    <dbReference type="InParanoid" id="A0A194X828"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="34878" checksum="B0464199C6E8B747" modified="2016-10-05" version="1">MELDDKLKHGPGPDPTLTKCRLRTYHPAASTFLDLVDDPTGHEWQGAQRFKLRAGTRKASTKLIQEPSDLRAALQEIHSVPPITDWPAAQYVNDTDQQLDAIYQLMNPPSHLGNVELWNNDRTTLWEGGAHGSDAPLTHISRRKRLDIALESMKNRRLRSRSQLKPNRFYEDRITIPQGAKHAQKRTYSKATDFKRKAIQLLIKGKICSARPDTGSDRNIITEAFAKEHNIKIQQREEDKDVFVVGNGQYTRSVGKALVSCALFGGSESEQSLWFHVMAKCSAPIIMGREFLRKIRLYTENTHLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8L9</accession>
    <name>A0A194X8L9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_782764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ16516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070871.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8L9"/>
    <dbReference type="GeneID" id="28832344"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782764"/>
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    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30924" checksum="69ADBB3FC1156D58" modified="2016-10-05" version="1">MVFKKAAPSFTNFPKLPTEIRIKIWEEASYLPRNVDIWPDRSESVPGEWWDPLYAGGKQTLRACFGFKSTLEHDVQISVPHRIYVNWKSDTVFPVPLGDSDWHTDLLERPEISKVAMNIAEKCYHFKILRPSLEEAILYYLDPLMDQDALSSYFDHFEVSFRPFNRRGPPKRLRELFDLNKAYIETDYEVMIENEARKRLPDNHIILNAEDDVERNRALELEKEKLRLLHPIPVVRYMRLFLNGKDSSNIQNRYLSSAPQIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8R4</accession>
    <name>A0A194X8R4_MOLSC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070921.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8R4"/>
    <dbReference type="GeneID" id="28833199"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_87094"/>
    <dbReference type="InParanoid" id="A0A194X8R4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="191" mass="21519" checksum="04FD979C92AE49A4" modified="2016-10-05" version="1">MTVANNATSGSHDRQSLVRQKFGFEFSSTRSRSLRIYHKVFAQLFSQQLRSPLRLSISTRLSTKNQAATMSDSSSSTATQESSAPKWLTRSNSSMMNLLNNYFEDKEQPRPSNLYRFYWLCCHHPKSTLLSSPSKIQCLLRNHLMDSQCGRCAHKICPSCKRIAQQESADMGVGEQDLAEVLETADARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9I1</accession>
    <name>A0A194X9I1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_83922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070787.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9I1"/>
    <dbReference type="GeneID" id="28833171"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_83922"/>
    <dbReference type="InParanoid" id="A0A194X9I1"/>
    <dbReference type="OrthoDB" id="10527307at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="268" mass="30347" checksum="084F8B856474F493" modified="2016-10-05" version="1">MKMAGPIRVNPPWNPLWNARAQIPPALIRRPWLRGSELLIDTGRNHWVVTPTQLRREWPELYRSLRASGNRVAIQPSKPWYEFRSLEDYSYDSAAWENIMAMMATRGNALLAPYITNPPHLDLLLNEMLQHRFNPIAQAYLYDATIPLLGRVSELLEKNGGFWPPSNIVFQLIQKCQALVPSVARLGPGYIYDLIVCIDRISGQDHQTLINTLSMINDIQDLALLGQLCDEQALAKVYGGEGSTLAIRIGSLIYDLSWDAYAVDRGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9T6</accession>
    <name>A0A194X9T6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_748087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071276.1">
        <property type="nucleotide sequence ID" value="XM_018221144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9T6"/>
    <dbReference type="GeneID" id="28830870"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_748087"/>
    <dbReference type="InParanoid" id="A0A194X9T6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="214" mass="24035" checksum="738E05DD0085AB42" modified="2016-10-05" version="1">MSDSHRSNEEDVQGSKFKAPKHKSAAGSYYSSQDSIEEEMSSGSKKGSKGSGSKDESLNPLEEMMKMRGGPGRNPTQQLLMQYGAPPGVGMGMEGRGGVGGIGRLADMAKNGRTDVEGELARAKMMKKRKEFEIAAEKKKIERFELMQANKALSAKDKQKLLEDAHQKKQQLLQQLYENEQELNDAIEVNGGRRPKPRDYYHITNDRHYERTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9U7</accession>
    <name>A0A194X9U7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071291.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9U7"/>
    <dbReference type="GeneID" id="28823662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_67974"/>
    <dbReference type="InParanoid" id="A0A194X9U7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="78" mass="9009" checksum="4BBFCE20C0A6D9C3" modified="2016-10-05" version="1">MKGKAGKWFSSLDDEVFGIMTYELEGGKEDPTSFEGEGGYEFDFWCWGFGYLFILSFITVFGIFSWRGIQKFKQCLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA33</accession>
    <name>A0A194XA33_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_669463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071388.1">
        <property type="nucleotide sequence ID" value="XM_018213100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA33"/>
    <dbReference type="GeneID" id="28822826"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669463"/>
    <dbReference type="InParanoid" id="A0A194XA33"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27147" checksum="433033A7E7F2FE00" modified="2016-10-05" version="1">MYGTMTAGAAGSGGNGLPPNGQQPAGTRAPRLLTRFTKEELKRLRVIFATTPNPTEAEIKSMNTTDFGGKYEVNKFKMWFWHERNKAVQAAIPKSQVARPMNSVVPESQVAHSMSPPPRGHPRPSTFARQGFAYKGPYDADFVEAPSAAGFNDAQLDILHDELLKYPKKHLKVPSDRDENLAEMTGLSKMEVSNFFYYHLDNLENMARSSARASGPAPPVFSCPAPLPPNDQVNERAKKLLDDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAC7</accession>
    <name>A0A194XAC7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_71969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAC7"/>
    <dbReference type="STRING" id="149040.A0A194XAC7"/>
    <dbReference type="GeneID" id="28828240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_71969"/>
    <dbReference type="InParanoid" id="A0A194XAC7"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="36727" checksum="178F25ADDA025493" modified="2016-10-05" version="1">MTSTNPTQNLAAVLESPGARLKVLPRPIPKPGPNELVVRNHAIATNPVDWKIQDYSFAIKTYPTVLGSDGCGVVTEVGSSVTKFKKGDRVTGFGAVIYNDNADHGSWQTYTVLKDIATTKIPDFMSFEEGSVFPMAMATSAVALFTILSVPLPTGSAPTAQKSGLLIWGAASSVGISAVQLARNLGFKVFATASPAHHQTIKSLGAFEVFDYRDANVVEKIVAAAKAAGTPISLGFDAVTEGKQSAEILVSSGGKRGKLCLALEWDEKEPRPDGLEITQTGALRAGTDQAEMGKWFFNEYLEKALQDKSIVAAPEIEIVEGGLASAQKAFDKVKAGVSGKKVVVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAU9</accession>
    <name>A0A194XAU9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_684376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071650.1">
        <property type="nucleotide sequence ID" value="XM_018214870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAU9"/>
    <dbReference type="GeneID" id="28824596"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684376"/>
    <dbReference type="InParanoid" id="A0A194XAU9"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="649" mass="72876" checksum="63EAE24F7CA88BF9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB85</accession>
    <name>A0A194XB85_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_696862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071786.1">
        <property type="nucleotide sequence ID" value="XM_018216865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB85"/>
    <dbReference type="STRING" id="149040.A0A194XB85"/>
    <dbReference type="GeneID" id="28826591"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696862"/>
    <dbReference type="InParanoid" id="A0A194XB85"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="348"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="572"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70965" checksum="83C0068D8506693F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBA9</accession>
    <name>A0A194XBA9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_584523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071815.1">
        <property type="nucleotide sequence ID" value="XM_018209270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBA9"/>
    <dbReference type="STRING" id="149040.A0A194XBA9"/>
    <dbReference type="GeneID" id="28818996"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584523"/>
    <dbReference type="InParanoid" id="A0A194XBA9"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="92"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="385"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="660"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="897"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="937" mass="104834" checksum="9A72B837824335DA" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC50</accession>
    <name>A0A194XC50_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_60614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072094.1">
        <property type="nucleotide sequence ID" value="XM_018210410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC50"/>
    <dbReference type="GeneID" id="28820136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_60614"/>
    <dbReference type="InParanoid" id="A0A194XC50"/>
    <dbReference type="OrthoDB" id="3565365at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="3">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="26259" checksum="E71791C45FB869B8" modified="2016-10-05" version="1">MPIPPSSTSPALLVSSVMNVMQISSTLDINIIPSASPTPSTPSGLTPTDDGVCGNGVTCLGWPDGQCCSEYGYCGSDAGFCGIGCQSEFGICGMPAPPSSSLPPAVPSSTIAAPAMSSSAAPNCPSSASLDAYNCGTYYTETGTYAGFVWDQLFIGSCLTEDPNNPGNDPESPAITNEIASGTTAAMLAGACGYLNACMNWAIPQAYDNVDFHLLQDTADTAHWECVAYYDNAGGNYFDVTNYNVLLAYGYDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD88</accession>
    <name>A0A194XD88_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_684069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072493.1">
        <property type="nucleotide sequence ID" value="XM_018214808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD88"/>
    <dbReference type="FunCoup" id="A0A194XD88">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD88"/>
    <dbReference type="GeneID" id="28824534"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684069"/>
    <dbReference type="InParanoid" id="A0A194XD88"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ18138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="16593" checksum="1EC3CFF945F3201F" modified="2016-10-05" version="1">MADSLIYCPVYAPFFGAMGCTSAIVFTCFGAAYGTAKSGVGICAMGVLRPDLIVKNIVPVIMAGIIGIYGLVVSVLISDGLKQQLPLYTGFIQLGAGLAVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLMNSKASLDVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDQ7</accession>
    <name>A0A194XDQ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_746585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072663.1">
        <property type="nucleotide sequence ID" value="XM_018221095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDQ7"/>
    <dbReference type="GeneID" id="28830821"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746585"/>
    <dbReference type="InParanoid" id="A0A194XDQ7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="383" mass="43296" checksum="32042E63891C9949" modified="2016-10-05" version="1">MGPQNSPDYGEFVDSDGEGDVEDVSEPLERYDRGLYYPLCIGEVLAGRFRIEHKLGWGGYSTVWMAHDLQYRKSVALKIMIPGEKGEYEYQMQNEILRTVRDTSHLVAHEGSFLLPGHGGNYHRVLVLPLLSLSLGYRAIQLSVATRVLAAKQLLVALKGLHDVGLVHREMPSVAEYDTATKYQRLGRPKKVLLGDYLWKRGELVQQMTIPLDLLGSKLYLGDFGLTIKDGISVSIKQQAPYCFCAPERLHGTDPSLASDTWSFMCLFAALYLGNNVFYGNGGGSTAFSWVEQLGAMPEQWKGKFWWPEEVNDTWYDHTTNPDPERDLAARIARMRPDTSQAERELALSVMQKAFCYLPERRITAAQLLQDPSFRAMLEIYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDS7</accession>
    <name>A0A194XDS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_45909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072683.1">
        <property type="nucleotide sequence ID" value="XM_018207670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDS7"/>
    <dbReference type="STRING" id="149040.A0A194XDS7"/>
    <dbReference type="GeneID" id="28817396"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_45909"/>
    <dbReference type="InParanoid" id="A0A194XDS7"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="136" mass="15179" checksum="8A14801C01912D42" modified="2016-10-05" version="1">MPLTMFKQPRVILGLMTFGKDAGSGARITSMDEYNKMLDHFQAAGYNEVDTARSYVGGTQEAWTRDAKWKDRGLALATKSYPHKAGTHAAEVITEQLNTSLKELGTDCVDIFYLHAPDRSIPFTETLEAVDKLHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEA0</accession>
    <name>A0A194XEA0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072858.1">
        <property type="nucleotide sequence ID" value="XM_018219642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEA0"/>
    <dbReference type="GeneID" id="28829368"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732062"/>
    <dbReference type="InParanoid" id="A0A194XEA0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="32442" checksum="5D2DC638E7350A6C" modified="2016-10-05" version="1">MREPGEDISVGHMSTELAQRDKQLKYLSEQLAEKDKELQAQANKLTAQQAQLKNQSFEPAQLMWHDNPAAPLATEKLKDEIEDHKVYNRKLAQANKILKTQNETLDAEKEDLQNQLKTSNNNEDLLLLINRCRELKDEAETLRAENQLLTRAANNARFEADVQAEEERNIDQLFEGGIEQFDNNRIEMLMSRNRELKAANRGFKLELKARRSSMGAAFSGDLETDDEDDDELEMTGATGGSSTLHRQSQSSATRARPLGPAPPIPRTLPEGVVPVRAHLRHMHKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XER6</accession>
    <name>A0A194XER6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Norsolorinic acid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_696161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072989.1">
        <property type="nucleotide sequence ID" value="XM_018216808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XER6"/>
    <dbReference type="FunCoup" id="A0A194XER6">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="28826534"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696161"/>
    <dbReference type="InParanoid" id="A0A194XER6"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="37624" checksum="C53A8CAD371C1452" modified="2016-10-05" version="1">MAAFAPPPTPKTGLGFYRNLSPTASVRVSPLCLGAMNFGDAWAHMGTCTEHEAILDYFYANGGNFIDTANNYQKGRSERILGEWMEKRGVRDQMVLATKYTTPYRTGYGDKEIIVNTGGNGTKSLKSSVELSLKNLRTDYIDLLYLHWWDHTTSIPEVMQSLNDLIVAGKVHYLGVSDCPAWIVSKANQYARDHGLRQFCVYQGNWSAATRDFERDIIPMTIAGHFKTDEQRAATKKDGRNFMPPTEHILSVSRALEAIAKKKNTEITSIALAYVVQKRPYVFPIVGGRTMAHLKSNVDALSLELTKEDMDEIEKASPIDLGFPHSMISLAIAPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEW2</accession>
    <name>A0A194XEW2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_582240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073085.1">
        <property type="nucleotide sequence ID" value="XM_018209153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEW2"/>
    <dbReference type="GeneID" id="28818879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582240"/>
    <dbReference type="InParanoid" id="A0A194XEW2"/>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="137" mass="14524" checksum="681E19EDE1201FF3" modified="2016-10-05" version="1">MQPPVHVTKSSELDAGTGGQTEGMLRMGAIVGRSDKICASVMLAKPHTSSAVHHHGEQDTIVYAASGHGSIVSEAERKGKKRQPLSPGDFALIPAWTEHQEINDSDSDVTWIITRSGGEPVVVNLEGWGGGVKIMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF69</accession>
    <name>A0A194XF69_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_696282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073168.1">
        <property type="nucleotide sequence ID" value="XM_018216819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF69"/>
    <dbReference type="FunCoup" id="A0A194XF69">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="GeneID" id="28826545"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696282"/>
    <dbReference type="InParanoid" id="A0A194XF69"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="551" mass="60507" checksum="752233861A0A4EBE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFU2</accession>
    <name>A0A194XFU2_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_475031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073393.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFU2"/>
    <dbReference type="GeneID" id="28817528"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_475031"/>
    <dbReference type="InParanoid" id="A0A194XFU2"/>
    <dbReference type="OrthoDB" id="3565260at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="261" mass="27925" checksum="94F29DB44EF6BFC5" modified="2016-10-05" version="1">MLILKVANGPVLSEQAPARTPPGRERIVTNMTADDPTKPWIPTHLRQPSAFGAICRMADMTGMKLEELTTDGVSIPGIPRNRPVSPNIPRASAIQHQMPPPAPSPAVTTQDEDDPYGWMAAIVNGPDMSDFHVAPTATVAEPARVASYSEMDVDMADDSAPIVSPRTFHIGTLADSQWASTRNSTFQQSQPVSRGPLSSSVSGQPLNSFSNSTENVKPTAQNVPSQAPSQSNAPISTVLTRALAEQKPDKKLATLKDSRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFU6</accession>
    <name>A0A194XFU6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_716658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073398.1">
        <property type="nucleotide sequence ID" value="XM_018218282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFU6"/>
    <dbReference type="GeneID" id="28828008"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716658"/>
    <dbReference type="InParanoid" id="A0A194XFU6"/>
    <dbReference type="OrthoDB" id="3562896at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="584" mass="59029" checksum="40B57741800A3403" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFW5</accession>
    <name>A0A194XFW5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_475766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073418.1">
        <property type="nucleotide sequence ID" value="XM_018207807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFW5"/>
    <dbReference type="STRING" id="149040.A0A194XFW5"/>
    <dbReference type="GeneID" id="28817533"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_475766"/>
    <dbReference type="InParanoid" id="A0A194XFW5"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268249" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ19063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="477" mass="51175" checksum="89FB9EF3F396A9CD" modified="2016-10-05" version="1">MMRSFAPRLSVLALLSVCSRVAMGIDLDLTSQDSIKSVASTIAYDMMTYYRGNYSGQTPGLLPGPPPNPTITDAGYFWWEAGGMFGALIDYWYYTGDSTYNDVVQQGLLYQVGSGDDYLPANQTNGMGNDDQGFWGLSAMTAAELNFTNPPSDQPQWLSLAIAVHNTQLARFDTVCGGGLRWQAYPFLNGYNYKNSIANGCFFNIAARLARYTGNDSYADTATSTWDWLTAVGLIDNSYNVFDGTDTGTNCTIINKQQFSYNAGIFLLGAATMYNYTNGSTQALWQTRVEGLLNQTINVFFPNNTGFEVTCEATLIHCTIDMLSLKAYLTRWLAASTKVAPFIYDRVMVLLQTSARQAALQCSGSPADHPNGRMCGLSWYKGAVWDGTSGVGQQMAALEVIQSNLIQQAAAPLTGSSGGTSQGDPSAGTSTGSSQDPTALLPPTGGEKVGAGFLTAVVTITVVGGLVWLSLPDGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGJ2</accession>
    <name>A0A194XGJ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear pore complex protein An-Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_488387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073670.1">
        <property type="nucleotide sequence ID" value="XM_018207873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGJ2"/>
    <dbReference type="STRING" id="149040.A0A194XGJ2"/>
    <dbReference type="GeneID" id="28817599"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_488387"/>
    <dbReference type="InParanoid" id="A0A194XGJ2"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="97743" checksum="A8BD7BBCDD1630C7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH34</accession>
    <name>A0A194XH34_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_581524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073806.1">
        <property type="nucleotide sequence ID" value="XM_018209114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH34"/>
    <dbReference type="STRING" id="149040.A0A194XH34"/>
    <dbReference type="GeneID" id="28818840"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581524"/>
    <dbReference type="InParanoid" id="A0A194XH34"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="129" mass="14034" checksum="41557ACA235B47A1" modified="2016-10-05" version="1">MPLTVTNEAPAAVAAWLKSTATPTKSSFLVVYASLTNGRSWCGDCREAESFVNSKFASGAEEVKVAYAGQRDEWRNSDNPWRQAPFSVTNLPTLIKVTGDGAFEKLVEGDVYSQKKLDSFVGDPTKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH38</accession>
    <name>A0A194XH38_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_731510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073442.1">
        <property type="nucleotide sequence ID" value="XM_018219580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH38"/>
    <dbReference type="GeneID" id="28829306"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731510"/>
    <dbReference type="InParanoid" id="A0A194XH38"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="394" mass="43932" checksum="969C24C867547BA0" modified="2016-10-05" version="1">MQMPSLSVIESFPTPNYVDPAVRGPANIITVSIFFPLALLIVGIRTYTRTCLSKSFGADDWFILAALLPTTAFAIMTLLAELHFGWNRHIWDVQLSTISTGLKIILCTEVLFCLATSLTKLSMLTLIYRLVSHSSSIISRVILGAIVLVSAQGTAFVFAAIFQCRTPSLYWTLSFKPQPECISETKLLLGAGIVNTITDLVVVVLPVPIVWHLKIPFKQQAILITLFAVGFCITLIGAVRTYYLYKVTSQWDKTWEAYPVWLTSSLELYVGIICASIPATKRFFTRLGLSWLRSSTASRPPTTTVPSHHTQEEHEIGVFPLHEYSDDKKDVETRSVSGAESGSKYKVPHLERPQTSYSKETAVGGISEVRDSDSQHCLVERDYEERVDTPSRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHR5</accession>
    <name>A0A194XHR5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_682571</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074031.1">
        <property type="nucleotide sequence ID" value="XM_018214532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHR5"/>
    <dbReference type="GeneID" id="28824258"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682571"/>
    <dbReference type="InParanoid" id="A0A194XHR5"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268266" evidence="11">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ19676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="282" mass="30100" checksum="39240F2F5BD5D10E" modified="2016-10-05" version="1">MGFYKYTAFALLALRAVSVFAADAVEEELESPPTTPNLAVSVSASFPSSEVFGVKLINGHATKAVLDFTNNEAEPVTIAVIGGALSTLQPLPEGTHPSAGIVRNITATRYDVSIPAGEKQSLPFTFTTDLHPQDLRLNLIAVIGSVAGEVYQIQAYNETVTVVEPATSIFDPQIIFLYLFLLAAFAGTLYFVYKTWIEALFPQTKRGGKGGERAKRSSAGSKKAVPVDEQVSVIGADGPAVTTGAEAQKAYDESWIPEHHLNRPSAKRVKSGASSKTKARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ45</accession>
    <name>A0A194XJ45_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_694965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074625.1">
        <property type="nucleotide sequence ID" value="XM_018216741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ45"/>
    <dbReference type="STRING" id="149040.A0A194XJ45"/>
    <dbReference type="GeneID" id="28826467"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694965"/>
    <dbReference type="InParanoid" id="A0A194XJ45"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="19148" checksum="E3CD7A7D3966E847" modified="2016-10-05" version="1">MCKELRPDTAVPALSQAQDALLKLSILARLIGAKSVLEIGTLGGYSAICFAEAGAEVTRIEINPKHQEVARESVEGLDVEVILGAALEVLPKLSEEGRQFDIVFIDADFDDQWEHFDWAVKLTRPNGCVFLDDVDSDSIITKIGKDDRVTATLVPIVATHPMIPIPHILSFVVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJU3</accession>
    <name>A0A194XJU3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_640097</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074850.1">
        <property type="nucleotide sequence ID" value="XM_018211651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJU3"/>
    <dbReference type="STRING" id="149040.A0A194XJU3"/>
    <dbReference type="GeneID" id="28821377"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640097"/>
    <dbReference type="InParanoid" id="A0A194XJU3"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ20495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="25915" checksum="E5592C6006EE7317" modified="2016-10-05" version="1">MSTPDIERLDLSDSDNEDLFASPSKASNPSQKAPTKPSENSNAPPQRNGESKYDAEAAREASLKKELESVRSINEVIEGVVSSLECAQGNMDTVSRTVTSASTLLNTWIRILSQTEHNQRLILNPNWQGASQDVADMENEMVLKAQAAERRAAEEERRREDARRRAEDEERQRQAGTTVRGARGTRARGRGVGRGSSVSGTGYVAGGSSSGTGRGTSQISRTGTGIGRGLGSTRGRARGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKB7</accession>
    <name>A0A194XKB7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_578430</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075010.1">
        <property type="nucleotide sequence ID" value="XM_018208944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKB7"/>
    <dbReference type="FunCoup" id="A0A194XKB7">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKB7"/>
    <dbReference type="GeneID" id="28818670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578430"/>
    <dbReference type="InParanoid" id="A0A194XKB7"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140472">
        <property type="term" value="C:cell cortex of non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035842">
        <property type="term" value="C:old cell tip after activation of bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051523">
        <property type="term" value="P:cell growth mode switching, monopolar to bipolar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902408">
        <property type="term" value="P:mitotic cytokinesis, division site positioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903500">
        <property type="term" value="P:negative regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="40"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="905"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="816"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ20655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="954" mass="105484" checksum="A7D947C80CEC33F3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKN4</accession>
    <name>A0A194XKN4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_666321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075024.1">
        <property type="nucleotide sequence ID" value="XM_018212897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKN4"/>
    <dbReference type="GeneID" id="28822623"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666321"/>
    <dbReference type="InParanoid" id="A0A194XKN4"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="59553" checksum="B98CCA001A434EB8" modified="2016-10-05" version="1">MPPRGLRSFGNRALPYTPIRSASSTSNWSFRSAPSSSSTDSTTFWRTPPKKWKRSLSWIREIPTPNITLIGQHISSRQKILFILLGLFTFLLLLPITHRHVTPITVYDLTKYQPPSAALPDTDKKRPDPIKWLEENSNNRHSVLDSYLSRFGMSGHGKPRAALISLVRNSELQGMMQSMRQLEYRWNSKYQYPWIFFNDEPFTEEFIAATRNSTTAKCYYEIVPKEHWSLPDWIDESRFMNSLEYLGTIGVGKGWMVSYHHMCRWNSGFFYKHPFLRNYDWYWRIEPDVHYFCDIDYDVFRFMRDNNMKYGFNMNILDDARSFPSLWSRTRAFAADHPHLIHPEADLGWLLDSQAGGEYNNCQFFSNFEIGSLDFWRGEANEAYFNWLDKAGGFYYERFGDAPVHTLSVAMFVPKSEIWYFRDIGYQHDINHHCPPHREAKCSCQPTRIDESFYKLVPLESPQRKPADTCIRQFLGGEWLKKKEGWTMAGEKAFGGDGYHGYELLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLJ9</accession>
    <name>A0A194XLJ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_450759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075002.1">
        <property type="nucleotide sequence ID" value="XM_018207607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLJ9"/>
    <dbReference type="STRING" id="149040.A0A194XLJ9"/>
    <dbReference type="GeneID" id="28817333"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_450759"/>
    <dbReference type="InParanoid" id="A0A194XLJ9"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="26710" checksum="D934939C3767A3B3" modified="2016-10-05" version="1">MASVTKNSLFGGDLPWSPLDWTSSDDRVRGGSSYSELSCSPFSPTAVFKGNLDIDTLGGAGFASQRTTGEDRNWDLSGYDGMLLDIAKTDGKQYTLILKDELLPKSPNGREQSTTSWEFDFKADKEGEKVFVSWNELKATYRGKEKKDAKPLDLKHVKRISIMMRSFFGTQQGDFSLTIRSISAFYKKDTSADTGEPYHDDPNQTSVPWTGDGLDNTSDAQQQQQQQSWVGWFSRFCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM64</accession>
    <name>A0A194XM64_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_431677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075690.1">
        <property type="nucleotide sequence ID" value="XM_018207476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM64"/>
    <dbReference type="GeneID" id="28817202"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_431677"/>
    <dbReference type="InParanoid" id="A0A194XM64"/>
    <dbReference type="OrthoDB" id="10679956at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="39522" checksum="EA7469A994096780" modified="2016-10-05" version="1">MPNPLPSPYSLIPSLSVPAYIFLSIFPPTSLTVSAAILQFHNMAFPTPLSILILIIATCLPFTLSSPQLPPPNDGYGDTPPPPASIPYFPGGIIMPTFSFPFMGGNPFTTSKKTTAGLPKTTAGLPPGYTFNPPPPPTSTTSSADGLPGYTFNPPPPPPSSNLPGLSRTPSVSPFPPPTTTPTIQTSNTVDGITGPSISNPTSLNIPPATSCLAPSLSLSVVTQIRTSTLTTHLVSVSYTTIIQPIQVTVPSVIVESLTLLQTLTNHYCPPPTTTLGGGGSNGNGGGGSSTCVWAPPITTGGYTIPFQPVVGGIGVGVSPSFESSYKISTTNFFYAETEVPYAEFKCQFQCGAGCSSYFVGFCTSHPLPSPLSLLLFPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMJ6</accession>
    <name>A0A194XMJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_730133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075706.1">
        <property type="nucleotide sequence ID" value="XM_018219443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMJ6"/>
    <dbReference type="STRING" id="149040.A0A194XMJ6"/>
    <dbReference type="GeneID" id="28829169"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730133"/>
    <dbReference type="InParanoid" id="A0A194XMJ6"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="289"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="657" mass="73770" checksum="40B2A0FE8A89B92B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMR4</accession>
    <name>A0A194XMR4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_609438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075422.1">
        <property type="nucleotide sequence ID" value="XM_018210518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMR4"/>
    <dbReference type="STRING" id="149040.A0A194XMR4"/>
    <dbReference type="GeneID" id="28820244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_609438"/>
    <dbReference type="InParanoid" id="A0A194XMR4"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613:SF9">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45613">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="96475" checksum="B81B7DC0F057F332" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN48</accession>
    <name>A0A194XN48_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_777979</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN48"/>
    <dbReference type="FunCoup" id="A0A194XN48">
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    </dbReference>
    <dbReference type="GeneID" id="28831900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777979"/>
    <dbReference type="InParanoid" id="A0A194XN48"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
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            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="56518" checksum="C4D3494FAD812BD6" modified="2016-10-05" version="1">MAVNKSVIGTSIIPLAGRGLFLTELVYAGELVFNVPRPWLCVVDGKNLRKTCDECFAYNGVLGTNNPEKTEPFLECKCKVVYYCSETCKANAWKTHHKIECAAYRKIAQTEPEINSLNPQFERRFRLITRLFALKKMGTIPEEDFKLFFDLAQGEEATDAWIEFTIERLYATGLTHMSPSKLRRWIQAVGNNDCEIDTPRILTTEELEGDEPYAKKVEAISLGACVDPYYSMINHSCMPNSYWVFNGRELQVRAERDMVAGEEVTISYIPRGAYVDRTISLASWGIHCTCQRCSKGVIEPTGQLREAIKEALDEQKWKYIRPTAQCRILRTLISDVWCDGNTWGAWPMRLLLVKLHDSLRAADQEWGVLQVLLRLRYSVDDQERPKAFLCERVQTLRLLVSFVGSVYHGRCGSGAGNLVVWIKSLYPYYRRLLLYEVQMCYGEDSALAKWELKRNMEEEGVEQGDEAEEKEIFRRSITLLLTWASKHESLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNF6</accession>
    <name>A0A194XNF6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_714823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNF6"/>
    <dbReference type="GeneID" id="28827883"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714823"/>
    <dbReference type="InParanoid" id="A0A194XNF6"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="57"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="628" mass="70339" checksum="80B5028B44B1632B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP86</accession>
    <name>A0A194XP86_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_392848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP86"/>
    <dbReference type="GeneID" id="28816928"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_392848"/>
    <dbReference type="InParanoid" id="A0A194XP86"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="129" mass="13966" checksum="0FE4F08CA613D7E0" modified="2016-10-05" version="1">MNVLEAQVDSSLTCVLTKSRTTALPKHKTALENVTSLHLSMPLNLKSSHTPHVRTLPGTIIPSHSSPKQQQKYKVQEMTSTQWLPAPRSPPRDPEALVNAPLRKPASVRADPSPLGLLIGTATGLEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQD6</accession>
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        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
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    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="397"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="264"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="381"/>
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        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
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        <location>
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            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
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            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="621" mass="67148" checksum="DCCDCF8635463ED5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRB9</accession>
    <name>A0A194XRB9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_636779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRB9"/>
    <dbReference type="GeneID" id="28821224"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636779"/>
    <dbReference type="InParanoid" id="A0A194XRB9"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061638">
        <property type="term" value="C:CENP-A containing chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ22599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="859" mass="93991" checksum="353545B6D3941619" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRK2</accession>
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        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_294738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076712.1">
        <property type="nucleotide sequence ID" value="XM_018206538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRK2"/>
    <dbReference type="STRING" id="149040.A0A194XRK2"/>
    <dbReference type="GeneID" id="28816264"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_294738"/>
    <dbReference type="InParanoid" id="A0A194XRK2"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
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            <end position="117"/>
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            <end position="69"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="731" mass="84212" checksum="497174E9A4745C50" modified="2016-10-05" version="1"> </sequence>
</entry>
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    <accession>A0A194XTH6</accession>
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                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
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    </feature>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51265"/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
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    </reference>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXS0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078982.1">
        <property type="nucleotide sequence ID" value="XM_018208665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXS0"/>
    <dbReference type="STRING" id="149040.A0A194XXS0"/>
    <dbReference type="GeneID" id="28818391"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572894"/>
    <dbReference type="InParanoid" id="A0A194XXS0"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="34227" checksum="499EDF492F17CFDD" modified="2016-10-05" version="1">MAKWRYNRFEAFQFGNDLWDPSHRFETSWLLRPWVLFGVRALISLYAFTVTFFIIGWEATDHDGNTIHDVRKSFSFFTVLCYWGICFYFLVAALHTFTYALNGGTPLLNRLPRPLQALHYLFWSTITTFPFLVTIVYWAILFSSFATTFALWSNISQHALNSAFGLFEIIFTRINPAPWIHLLWLIVLLALYCGLAYTTVATKHYYVYSFLNPNPPNDVLDSNGKKTNIGGVGKGAVVGYVFGIAVAIVIIFCLSRLLVWGRKWLTEKRLGMRGKFYAGREMGMGDVELEVQRAWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1H7</accession>
    <name>A0A132B1H7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_603653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947450">
        <property type="protein sequence ID" value="KUJ06235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060590.1">
        <property type="nucleotide sequence ID" value="XM_018210313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1H7"/>
    <dbReference type="STRING" id="149040.A0A132B1H7"/>
    <dbReference type="GeneID" id="28820039"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603653"/>
    <dbReference type="InParanoid" id="A0A132B1H7"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23001" checksum="C2A1C5FDAEBEF5D6" modified="2016-05-11" version="1">MHISESPLATALLVGDIQRNGVENIPKSATLHRRDPDTPVAPARHFNIVTGRGSVSFNFQPPPIAPAVPPTPANRGNNGRIPRPPNSWILYRSANHAKVKAANPDKSNNEISGIISSMWCDESLNVRQHYAKLAEIAKKNHKVAHPDWNYKPRKTVDIKRRRGIARAVISRPVELFAKTKETLTIIQGSGNQVENSVQSLGGLEASCYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2G3</accession>
    <name>A0A132B2G3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_406347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060943.1">
        <property type="nucleotide sequence ID" value="XM_018207301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2G3"/>
    <dbReference type="GeneID" id="28817027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_406347"/>
    <dbReference type="InParanoid" id="A0A132B2G3"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF3">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="54854" checksum="A782E193CACA46FB" modified="2016-05-11" version="1">MPAQGPLPRRMTRIVPENGYESPQSPESSGFFFGNGIIIDGERRRRNPFGDSNEDTAADDTVEEQDTAAECQQMEQQNEDAPAQRIVGFRDRVGSFTWTWFTMTMATGGIANVLHSIPYRSDWLKILGVIVFLFNLVLFILNCSLITLRFRWNPGSFTGSFKSPSESLFIPACVVSVGTILINMSQYGIAETGEWFQTVMQICFWAYAVLSFVASSGLYLIIWSTQTFPIHTMTPIWIFPAYPLLLMGPFAANLIDALPNSAAATRINSVAITFGALCIQGTGFLVSLMIYSAFIYRLMTQKLPRETTRPGMFVSVGPSGFTVAGIVHLGNTVIPKVMPNGFEGNGDAAFIIKLLSDLAGLWMWGLCLWFFLVSIGAHWQVMQPRHPEHHIRFDMTWFSFVFPNTALVTATQALGKSLDSNGLKIFGTVMAVILVGVWLFVFGMMIRAFYLRRLLWPGEIDGAEASRRRWIGKVEEAAANGASRLRHSNDTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4J4</accession>
    <name>A0A132B4J4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_692190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061189.1">
        <property type="nucleotide sequence ID" value="XM_018216485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4J4"/>
    <dbReference type="GeneID" id="28826211"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692190"/>
    <dbReference type="InParanoid" id="A0A132B4J4"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000099">
        <property type="entry name" value="Amidohydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="70"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36382" checksum="5EBA145DCA1F7A9C" modified="2016-05-11" version="1">MVPPLITLEEHFIATDALPNFSGKYSEQLKHVTGLADKLADLGNLRINNMDIGKISLQVISHGPFGHSPSQCRAANEQLSAAVKANPSRFAGFATLPMADPKAAAEELTYAIKDLKFVGALIDNHCDGKYYDGEEYRDFFKTVQELDVPIYFHPTWPSEDMTPRYSGNFSTGAELSLGASGFGWHSEVALHILRLFASGLFDLYPKLNIVIGHFGEMLPFMLGRIQELSPRWGKLERNFKQVWDENIWITTSGIWSLDPMATILRNTKIERILYSVDYPFARNERGLEWMEELEASAMVTKEQLEMIAYKNSEALLKVKLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B505</accession>
    <name>A0A132B505_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_790154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061112.1">
        <property type="nucleotide sequence ID" value="XM_018223338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B505"/>
    <dbReference type="GeneID" id="28833064"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790154"/>
    <dbReference type="InParanoid" id="A0A132B505"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287847" evidence="4">
        <location>
            <begin position="24"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="42252" checksum="7C810EFDCBC27B41" modified="2016-05-11" version="1">MMSVRKLSFYFASLACVFSLSSCFSNFTDVAEVPQIYGNRAGFSVDAIRAPPSPRNGTEISAISGSDSHWWATISVGNPPQLITVILDSGTVDLSLMSTFINPAQRGLAPVYDPDRSNTAVLVDGYTWYQQYAGSAPNMGWVVQDEVRVGGIFLTNFTFEIDNVTVIPHITSPPYGTLGLDPDPNGQPTSPKRMPGWLQTVMNFVHQPVFCIDFRRNIFRGVIDFGYIDSKKYNGSIAYTPVTQPTLWSINIDGVGIGGGPYQHNPFEVFFDTGGDGLVFPRWAIDNYFAQVPNSTWDAALNTYSFDCTLFVQGKLPNITFGIGDSYRGVVPADHIHVGLLHDYVCVTSLRVGDRPSWGTSIIATQFVVFDYGGKRMGFAHKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B584</accession>
    <name>A0A132B584_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_660330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061925.1">
        <property type="nucleotide sequence ID" value="XM_018212546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B584"/>
    <dbReference type="FunCoup" id="A0A132B584">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B584"/>
    <dbReference type="GeneID" id="28822272"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_660330"/>
    <dbReference type="InParanoid" id="A0A132B584"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="874" mass="98892" checksum="A93359BDE8B8F1F3" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5E4</accession>
    <name>A0A132B5E4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_742789"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="314"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="605" mass="70197" checksum="DAD7CB3D122D4070" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5G9</accession>
    <name>A0A132B5G9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_766321</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062010.1">
        <property type="nucleotide sequence ID" value="XM_018221725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5G9"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_766321"/>
    <dbReference type="InParanoid" id="A0A132B5G9"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="33868" checksum="91124EAAAAED335F" modified="2016-05-11" version="1">MAPIDYDTTLPLGAWDSHVHIVDEDIFHLHPDHPYRPRKADLNDLLQFEKSNGIEHVCLVAFSVYGTDNRSILDALVKLKGKGRAVVCIDPDEITDKELRSMHGLGVRGVRLNLRTRSQTIDPILFTKLLRKYADKIRPLGWALQIYTSLDQIKHIAAVIPSLGIPIVFDHLGSPEGTRPPKALLGYSELMSLLKEKLVYVKLSGTYRFPNTPGIGEYVEEILRCAPTQVVWASDWPHSGGVSRNPGGDRKKVQEYRVVSTTDFIVRCKEWCKYDEDLIQKIWVENPRRLWQYDAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5Y8</accession>
    <name>A0A132B5Y8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="10" type="ORF">LY89DRAFT_789492</name>
    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062181.1">
        <property type="nucleotide sequence ID" value="XM_018223259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5Y8"/>
    <dbReference type="GeneID" id="28832985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789492"/>
    <dbReference type="InParanoid" id="A0A132B5Y8"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="716" mass="79391" checksum="1D27CF5B52AA1882" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B680</accession>
    <name>A0A132B680_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062265.1">
        <property type="nucleotide sequence ID" value="XM_018223269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B680"/>
    <dbReference type="STRING" id="149040.A0A132B680"/>
    <dbReference type="GeneID" id="28832995"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789553"/>
    <dbReference type="InParanoid" id="A0A132B680"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="58"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ07910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="340" mass="37196" checksum="5C36AED72308FE97" modified="2016-05-11" version="1">MAFSSSEKPKVLALTPPKACGADYLEDFKSKFQLDILSVKNRAEAVPAIAEAVAKTGPYSAFIILMGTAPFEPFDGEFFTPLVPECKIVVSASAGYNEFPVNWLTDKGIWFCNTRNAVSEPTADMALFLTLAVCRDTTRAENSVRNGLWRNNHVPCTDPSDLIVGIIGLGAIGKHYARKVNAFNMKVQYHNRTRASPEIEALYGATWCPNLEELLRTSDVVSVSVPQNAETIGLISRNEFSQMKDGVFFINTARGPIVDEAALIAALESGKVARAGLDVFTGEPNVNPWFLKSDKVVIQPHLGGLTNRAWRDAERECFANIVALYETGRPVAPVNDIKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B698</accession>
    <name>A0A132B698_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ankyrin repeat-containing protein P1E11.10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_344839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062293.1">
        <property type="nucleotide sequence ID" value="XM_018206875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B698"/>
    <dbReference type="FunCoup" id="A0A132B698">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="GeneID" id="28816601"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_344839"/>
    <dbReference type="InParanoid" id="A0A132B698"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24166" checksum="58569A344C180D30" modified="2016-05-11" version="1">MPPPPPRQVNVFLLAADNPLELLTLLRENLLLASSQDEHGYSLMHAAASYNHLELLRALVSEFHVNVDLKDEDGETALFVAETVDCARILVEELHADITIVGDEGKTAREKFADENDFPEVAVYLRMKELESQVNGSSAANGIHSPPALPEGVQVNIGTMAEDEAGEVADPEFRRRIEELAAREDFQGEEGQRALRELITEALRGEVGQEREVRQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7F5</accession>
    <name>A0A132B7F5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_600161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062693.1">
        <property type="nucleotide sequence ID" value="XM_018210143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7F5"/>
    <dbReference type="STRING" id="149040.A0A132B7F5"/>
    <dbReference type="GeneID" id="28819869"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600161"/>
    <dbReference type="InParanoid" id="A0A132B7F5"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="3">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="421" mass="47686" checksum="58CAFE200763074B" modified="2016-05-11" version="1" fragment="single">RQESVRSLMNGEPLVLHGWTLTAPIGFRAVCKTIRETGFATSKLPIIVSLEVHADAEQQEVMVEIMKEEWKGLLVEMPNEDCNPDERLPRLGELLNKILVKVKKAPSVPLDKQELTPSSSLAPIPTRDTDSIHSGSEDERGSTSGKKKVKICENLSNLGVYTHSEHFVSFEAKSAKKPPHIFSIGESQILDLHDTRKDEMFSHNRDFFMRAYPASYRIDSSNLDPSIFWRKGVQMVALNWQNLDMGMMLNEGMFAGEHGWVLKPPGYRSDHTEPIQYKTLDLKITIFGGQHLPMPPHQTLSGFNPYIRCELHVEKEQESSSETAKSRKQQTGYQKGDHPDFGPEGCALVFPTMNKVVEELSFVRFKIEDARYAKDNLAAWACIRLDRLQQGYRFVYLLDAKGQATAGLLLVKVEKKTVSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B846</accession>
    <name>A0A132B846_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_764533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062778.1">
        <property type="nucleotide sequence ID" value="XM_018221638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B846"/>
    <dbReference type="GeneID" id="28831364"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764533"/>
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    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
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    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287949" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14694" checksum="9F76CEC89378DDD4" modified="2016-05-11" version="1">MHLTSFFAFALLSLLRGASASIYNITFPATVEVHKQFNVTLLTEGNIQTSQDVVVVFGLQPGSGLEGSLGYYKLTTHSLGPAVSNVEYPIVFKAILPPNFPSTNAKYPVTATVFSLLGTYNTPSFATFSDTVSTTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8A8</accession>
    <name>A0A132B8A8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">Myocyte-specific enhancer factor 2d</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_725078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218948.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B8A8"/>
    <dbReference type="GeneID" id="28828674"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725078"/>
    <dbReference type="InParanoid" id="A0A132B8A8"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
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        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54521" checksum="729D77E55AA702AD" modified="2016-05-11" version="1">MDRPAQDIPGYYYDREKRKYFKVQGSTAPADTAYSAEDVKRRKTRDRRREIQAKNEKRQMGRIQRFANLEDTLSGFVMKREYGYGPGLDCPRSILAAGLVAQGFYTPFPLDIEPYFAVSPHLDREKDLVFTVHSAHDDWVISSLASFSPKNNVFNKYAGNRTANWNFKFGSPGATTSLSSHDTTGFHASTWLSGSSEVGIGLWRGLSDHPTISLGTGNVRGNAEVYTSTAAPPESSLLFAFGTNKGILMLDKERQDLHWLKDKNSHVAHTSEMQLYSAVCFLTAAGSGQNPNTLLGGGHCGQAYRIDLRDPKFNSEATVITHPNAIIHIRQVDEHRIIIPGIPNQMRQYDLRYLKLANERPHSSKRTTLVTAPYVEYPDYKLLAGISGFDVDTESGLVAAAQWGNYDTPYVQLFSLKSGNKIPFPAFKNKSSKKKRKGERMYPGTAPKCIRFVKDREGSMKSLYVSRDSGTILRFAWEAEKDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Y6</accession>
    <name>A0A132B8Y6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_724854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063223.1">
        <property type="nucleotide sequence ID" value="XM_018218936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8Y6"/>
    <dbReference type="FunCoup" id="A0A132B8Y6">
        <property type="interactions" value="1166"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8Y6"/>
    <dbReference type="GeneID" id="28828662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724854"/>
    <dbReference type="InParanoid" id="A0A132B8Y6"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12319">
        <property type="entry name" value="RRM4_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000452">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000459">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="480"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="596"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="701"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ08868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="825" mass="91485" checksum="D29F248A81C82796" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Z3</accession>
    <name>A0A132B8Z3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_741710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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    </evidence>
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    </evidence>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="26530" checksum="E151F78588AAD26D" modified="2016-05-11" version="1">MNSTIILITGANSGVGYATTKVLVSASKDFHIIMTSRSLTKVKTAMAELEASKPAGSLSALELDVTDQQSVDTAVAHVTSQYGHLDVLINNAAIGSRGPDVMKRFQDCLTTNVIGPAVVAAAFRPLLLKSSNPYSLFVSSGAASMGKASDPTDAVYKVNIPNGGAYRVSKAALNMLVLQEWIKYAETGLKVFAVCPGFVRSNLRGKSEEEVSGWGQAGDPVVAGEMILGIVKGERNADVGKFVWKDGVYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAQ0</accession>
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        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_788339</name>
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    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063847.1">
        <property type="nucleotide sequence ID" value="XM_018223160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAQ0"/>
    <dbReference type="GeneID" id="28832886"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788339"/>
    <dbReference type="InParanoid" id="A0A132BAQ0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="20741" checksum="2BB54B10E1F7A0A4" modified="2016-05-11" version="1">MSSSQQLSTVWDSHIPRPDADLETRLRCVLLDFFYPLPPTPIQGPFFTMSFKLCVLIQMLASEFPEYFLDTEPHVHSIRFSIETSLGRADRDLQLDVPMFCIIEAKATAMRAKYTILEGLNSGILFSIQASIVVMWPACVNVAFPVGWGWDSIVSILKHEGGSKYDQVGEERSAFMYDNNLNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBE7</accession>
    <name>A0A132BBE7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_690139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064066.1">
        <property type="nucleotide sequence ID" value="XM_018216039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBE7"/>
    <dbReference type="FunCoup" id="A0A132BBE7">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BBE7"/>
    <dbReference type="GeneID" id="28825765"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690139"/>
    <dbReference type="InParanoid" id="A0A132BBE7"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ09711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="35156" checksum="AEC5D36B1AE6D68B" modified="2016-05-11" version="1">MVDRPKKPSALATTPGLPPQAQLNISHDNSRVSAVLPTGESVEVLLFGATIISWKDAKGNEKLWLSEAAKLDGTKAVRGGVPLVFPVFGTAPDHAATAKLPQHGFARSSRWEFLGKSTSESSTLSATSAGDDSVKLDFGLSPSNLTEESKKAWPYKFGLIYSVTLGKEGLTTSLVVQNDGEQAWEFQTLMHTYFRVKDISTVSITGLESSPYLDKVLGPSSTGEPYTSPSAAVSLSSKVDRVYTPAGGPEAAVIIKEGGKKKFGIVRDNMNEVVVWNPWKDDAQGMGDFAPKDGYKEMICVEAGAVKGWQKLEQGETWEGGQVIMAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBX4</accession>
    <name>A0A132BBX4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_596886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064251.1">
        <property type="nucleotide sequence ID" value="XM_018209947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBX4"/>
    <dbReference type="GeneID" id="28819673"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596886"/>
    <dbReference type="InParanoid" id="A0A132BBX4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="591" mass="66560" checksum="E0A90154E4AEF895" modified="2016-05-11" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC49</accession>
    <name>A0A132BC49_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_689877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="59"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="318" mass="35722" checksum="7B068185DBEC5B58" modified="2016-05-11" version="1">MTVRSESDIELGGSTEQKSPRTFRLNILFACKSWVSSLFAKTERYEVRQTQIEDYREGYPRYSALIGAEKSFHICRRFSNLRARLLLLQQDKICLLEKHLEQIDRDEKAPLFLGSSRSDVNVERGAVIEGIQVALERYDNMVESNNKMLSYEIAKPRDVLSLQNWVSSTACLARDETAYLTQCEDLISVASPRDGMAEQLESWIEDIIVRFGRISCKLLSRDVSRDSYVYIFSRSKLARISRGIIACLVIAFLLAPVVVCNALSGLNSRLIVIAIATFLFVVLLSAMIKAKAVEMFVAGTTYATVLVVFVSGSSVITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD10</accession>
    <name>A0A132BD10_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_626713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064623.1">
        <property type="nucleotide sequence ID" value="XM_018211119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD10"/>
    <dbReference type="STRING" id="149040.A0A132BD10"/>
    <dbReference type="GeneID" id="28820845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626713"/>
    <dbReference type="InParanoid" id="A0A132BD10"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="122633" checksum="7100192A2ABA494E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEH1</accession>
    <name>A0A132BEH1_MOLSC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">LY89DRAFT_689916</name>
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    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064432.1">
        <property type="nucleotide sequence ID" value="XM_018215996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEH1"/>
    <dbReference type="GeneID" id="28825722"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689916"/>
    <dbReference type="InParanoid" id="A0A132BEH1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="18975" checksum="71135A2D84947626" modified="2016-05-11" version="1">MEHLTDAEFQQEIRKHQERIRQRDAAGLRPPGTSAWTGLSPADRETAFQIVREMARRRRLRGEPKPPRPTRICTEDDMNIGHDQIHAIAATRQQAYARLQAAQNGGVGVGYGSERPGSGIQGSGGGYGRRLSGSQAELLRKQLDVMNRRGSGSGGSQSGKSKKRSEYPPGSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BES7</accession>
    <name>A0A132BES7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_740580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064542.1">
        <property type="nucleotide sequence ID" value="XM_018220608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BES7"/>
    <dbReference type="GeneID" id="28830334"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740580"/>
    <dbReference type="InParanoid" id="A0A132BES7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="17017" checksum="3293C6B80FE5B4AD" modified="2016-05-11" version="1">MSSKAMEVSRDVEKGLQTLRQLSIDEVERDLERQRMDAVSAYDKESDDLRRVLVHMPTEQIRLKVLALFTSCTKLDIKLLAVMRRNLYGADEALPSPEFKAPNGRKVSVYDVEEVVRIAEDSGYRSQDVEKNKLAAGKMLELLTSRKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WST5</accession>
    <name>A0A194WST5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_758707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065375.1">
        <property type="nucleotide sequence ID" value="XM_018221442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WST5"/>
    <dbReference type="GeneID" id="28831168"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758707"/>
    <dbReference type="InParanoid" id="A0A194WST5"/>
    <dbReference type="OrthoDB" id="10550235at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="15676" checksum="4EEFC21898F5EA3E" modified="2016-10-05" version="1">MAAGQGSHSLKPLFQIQETGQPAPLQQPNNKPTSPKTAKATPLTSINFFAPPTGTTVDVSPVELVLVDVLAWLGPPTTLVVTFTATEEEAELLGEEVGVWLGVEAAAIEDVLTAAGEDVVEGGEVGAEVSDAEQPKPVPQQEGGMPYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT77</accession>
    <name>A0A194WT77_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_723391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065182.1">
        <property type="nucleotide sequence ID" value="XM_018218814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT77"/>
    <dbReference type="GeneID" id="28828540"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723391"/>
    <dbReference type="InParanoid" id="A0A194WT77"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="175" mass="19157" checksum="C4A86C5A02BFB375" modified="2016-10-05" version="1">MDMVPSWASDRIVTLVKDVIDSIEHGKVEYAEFKGGSSVVSMRTNVSFAGEARVRPSIRHILAQAPHNLPFAINATSRESASPDVKPQHSNIIYFKTLDTISPSTLQNLISKINSLVDVLNNDADQEYCYENTVKTFDDGYWEVGGKGRFGKDMLDGARIPVRLAVGDVGGVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU30</accession>
    <name>A0A194WU30_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_625548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065472.1">
        <property type="nucleotide sequence ID" value="XM_018211081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU30"/>
    <dbReference type="FunCoup" id="A0A194WU30">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WU30"/>
    <dbReference type="GeneID" id="28820807"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_625548"/>
    <dbReference type="InParanoid" id="A0A194WU30"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="358"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="591" mass="64801" checksum="078F3B803526E8B3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU70</accession>
    <name>A0A194WU70_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_239842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065579.1">
        <property type="nucleotide sequence ID" value="XM_018206104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU70"/>
    <dbReference type="STRING" id="149040.A0A194WU70"/>
    <dbReference type="GeneID" id="28815830"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_239842"/>
    <dbReference type="InParanoid" id="A0A194WU70"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
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    </dbReference>
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        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
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        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="318"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ11224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="38659" checksum="01897349BB3547B2" modified="2016-10-05" version="1">MHLIRRAAVRAAASRSSISSSRTINTASPFLLRSKTQSPIASSVFRRFKSDEQQKSQVESADGESGSVKSAIESASTYASEVAESVTESAQNVAEAAGFAPRERREERSGFEDRRGGGRFDADRPSPPPTNGIYVGNLLFDVTAADLEREFASFGTITNATVASDARGLSKGFGYVEFETQESAAAAIEGKHQALLEGRRLVVNYMKKNTRGEGRPELEPTKTLFIGNLAFEMSDADLNKLFRDIRNVFDVRVAIDRRTGQPRGFAHADFVDVESAIKGKEALMDKEVYGRKLRIDYSAGSRTSGGDGAPRGDRDGGRGGGRGGYGGGDRRGGGGYGGDRRGGDRGGYGGNRGGDRGGDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUA4</accession>
    <name>A0A194WUA4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_739449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065609.1">
        <property type="nucleotide sequence ID" value="XM_018220463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUA4"/>
    <dbReference type="STRING" id="149040.A0A194WUA4"/>
    <dbReference type="GeneID" id="28830189"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739449"/>
    <dbReference type="InParanoid" id="A0A194WUA4"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="380"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="706" mass="80424" checksum="5097516C4E7D4E1C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUQ8</accession>
    <name>A0A194WUQ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_786579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066053.1">
        <property type="nucleotide sequence ID" value="XM_018222997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUQ8"/>
    <dbReference type="STRING" id="149040.A0A194WUQ8"/>
    <dbReference type="GeneID" id="28832723"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786579"/>
    <dbReference type="InParanoid" id="A0A194WUQ8"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="92414" checksum="4105F09D8142EE38" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVG2</accession>
    <name>A0A194WVG2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_786543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066014.1">
        <property type="nucleotide sequence ID" value="XM_018222992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVG2"/>
    <dbReference type="FunCoup" id="A0A194WVG2">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVG2"/>
    <dbReference type="GeneID" id="28832718"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786543"/>
    <dbReference type="InParanoid" id="A0A194WVG2"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267505" evidence="6">
        <location>
            <begin position="17"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="8">
        <location>
            <begin position="121"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="658" mass="71499" checksum="346CACCC0E5B0E72" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX61</accession>
    <name>A0A194WX61_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_688190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066870.1">
        <property type="nucleotide sequence ID" value="XM_018215655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX61"/>
    <dbReference type="GeneID" id="28825381"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688190"/>
    <dbReference type="InParanoid" id="A0A194WX61"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25955" checksum="48CDBA7F1C005D63" modified="2016-10-05" version="1">MAPTKPLNVRWAKSFPTAHSSAAFSYTCTFTTSNKVCNKKFIRQCDLRRHEKNHGRAFKCSHCTRGFPSPKDRERHFNSRHKLTIKYFCPYEKCRDSMGPLSNGEILGSDDWGNGFKRKDHWRKHLQEEHRLSRETVGELQKNVAMPPTAVLRDEVWLAVLPPCISRTHRSSVSSEESKSVVKEEVRELVLESQDESDEMDDCEETIVVDSQPNGAWAEGYAEIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXV5</accession>
    <name>A0A194WXV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066874.1">
        <property type="nucleotide sequence ID" value="XM_018215657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXV5"/>
    <dbReference type="GeneID" id="28825383"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688194"/>
    <dbReference type="InParanoid" id="A0A194WXV5"/>
    <dbReference type="OrthoDB" id="3560866at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267577" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="9434" checksum="DFC2EF5E0EB7858B" modified="2016-10-05" version="1">MQAPHLLLLLILLTQTTSALPPPKTQACTCTVVFGNKAAQSIAKATVNSTIGLTGEDKSKKAGSADLLVGSGCVAAVSNESVNSCVTSQSCTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXX0</accession>
    <name>A0A194WXX0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_591931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067130.1">
        <property type="nucleotide sequence ID" value="XM_018209676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28819402"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591931"/>
    <dbReference type="InParanoid" id="A0A194WXX0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <strain evidence="7 8">CBS 120377</strain>
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        <property type="entry name" value="PROTEIN ALCS"/>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_755911"/>
    <dbReference type="InParanoid" id="A0A194WYZ6"/>
    <dbReference type="OrthoDB" id="3555312at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="515" mass="58459" checksum="F0D6A6338F2202ED" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0D8</accession>
    <name>A0A194X0D8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_157277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067692.1">
        <property type="nucleotide sequence ID" value="XM_018205462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0D8"/>
    <dbReference type="GeneID" id="28815188"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_157277"/>
    <dbReference type="InParanoid" id="A0A194X0D8"/>
    <dbReference type="OrthoDB" id="3763773at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34714">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34714:SF2">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="53249" checksum="AEC277C4A8736E1D" modified="2016-10-05" version="1">MSLYQLLDTRLRFYDDSEELVRKTESFGSTLLMRAPEINLANALSLLTVDQLNSITIEVYADVIALGDLVLPPSCSSVLLVARVIQTSNPVPKFKISRLPFLLRVYTLARGINLILDLETSRGITSSQIEFPKDSWGSGLSLAFNEPIKYYVNLDRLDGFRSLSVVDQLTDDGVLSSVWLQLRNNHLPRLLQYQILLASSMTASNPSVAYDMVYFVLAATAQQPKGFLIRSQAFSMAAYLIANTNDQTSRYVPRIDLSTAEIVLNKRLDAAQAFETAFITFQGQQDVSANFTSIASTTLDKAIDAQAQYNFLADLAESRYNSALAALKRAENNFQSLQTSLVPLQEAFKKGIEKWKKEQTLKAVGDALLAVVAVVGSIAAAVVVPPAGAAGLAAAGAAVPAAISGASSLAGTIKKIADLITKLKDLFTKIGPILDTVYKLVKGIEKLVQTLSAISPGDDAANLSLPASMGDDAINLSADWDAFDVQVQALMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0X1</accession>
    <name>A0A194X0X1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_687635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067969.1">
        <property type="nucleotide sequence ID" value="XM_018215544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0X1"/>
    <dbReference type="FunCoup" id="A0A194X0X1">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X0X1"/>
    <dbReference type="GeneID" id="28825270"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687635"/>
    <dbReference type="InParanoid" id="A0A194X0X1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="372" mass="39689" checksum="CC4651AE5F02D322" modified="2016-10-05" version="1">MTNIVILGASFAGVSSAHRILKQAGKTGAKIRVTLVSPNTHFYWNIALPRAVVPGQLSDEKVFQPIAPGFKQYPAGQFEFIVASAKSLGVEAKKVHLEILGSDEDKVIDYDFLILATGTSTKGGTPFKTLASTEATKDGIHNIQAQIKKAKTIVLAGAGATGVEIAGELGFKYGTSKEIILISKGPTILEAAIPSVQKVATQLLQNLKVKTKLKTQVVSSVEGADGRHILELSSGEKLIADVYLPTFGVAPNSSYIPKQFLNDRGFVIVDDYLKVKGADNVWAIGDVSDREPPQFLFADGQSAHIAKNIIKILSSQPSLPYKDGVRGMGLTVGRKAGTGHLGNVKLPGFLVHFLRKNLFIDKLAPTVSGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1N6</accession>
    <name>A0A194X1N6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_784743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068254.1">
        <property type="nucleotide sequence ID" value="XM_018222815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1N6"/>
    <dbReference type="GeneID" id="28832541"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784743"/>
    <dbReference type="InParanoid" id="A0A194X1N6"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000028">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein (AFU_orthologue AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267713" evidence="1">
        <location>
            <begin position="18"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="277"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="854" mass="92665" checksum="D09E325E62C79F09" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X222</accession>
    <name>A0A194X222_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_149357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13892.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="448"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="697" mass="79504" checksum="1F0E1626B2321D89" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X264</accession>
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        <submittedName>
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        <name type="scientific">Mollisia scopiformis</name>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="703"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="329"/>
            <end position="695"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="703" mass="76288" checksum="1CC7442404F28A6F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X268</accession>
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        </recommendedName>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="47555" checksum="36EC14AC23351B73" modified="2016-10-05" version="1">MAFQQGTTTDLAASLPKVNSHITSKVAPTQPALRCTVCDKDGATLCFVCGSASYCSRSCEDEDARCHQTVCPDFRGFLSAESPREDAKLALFFSEASVGPKLVWVVERNRQLMEVRGSHTHTVVVCYRDNFFWDGKFANNLSIFNFTQGEHKHDWRGPIAVLSQRGTLNSSGYDDITLTDLRVFRDFLMHYGEGLEKSLQYGGLRCVELSDPGLWERMMLCFMPKDAKMVKGVKISCMGDIRILKRPQFAHIEVPPNHPIFFNEDEGKAADASASTQISAHMNLPLIIRRTALDLGWKGLYNTHEDLANNVGPINEPAALLTTIIDTESKLWGGNDVGPEYELESGTVLEVRQDKKDLTVEQVKALVGYIRDHIKPAIEKEKRRESSLDKKQILSGRESILETLVTMESVRKHFKAWGDHTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2T6</accession>
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        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">LY89DRAFT_686816</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215369.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194X2T6">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2T6"/>
    <dbReference type="GeneID" id="28825095"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686816"/>
    <dbReference type="InParanoid" id="A0A194X2T6"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASH2"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="160"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="569" mass="62582" checksum="2FC1B352D45319BA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3J1</accession>
    <name>A0A194X3J1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_686419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069113.1">
        <property type="nucleotide sequence ID" value="XM_018215281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3J1"/>
    <dbReference type="STRING" id="149040.A0A194X3J1"/>
    <dbReference type="GeneID" id="28825007"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686419"/>
    <dbReference type="InParanoid" id="A0A194X3J1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31919" checksum="15EF55DBC7C811E9" modified="2016-10-05" version="1">MLRFFRKICHFDIKPANVFIGDRDQSEHRRLEVFKLADYGLSLFAPGPFISEMERVDWIEETEWRASPKYMSPEQLYQKHQNRDIGPAAGIWSVGSIMWAICAGKNPEIRYVFNHKLAKGFSQISGDPQVLFNTNLFPYSNHFINTLCGCLTYDPADRLTSDRLLKECLRMVNIYDKQSIDEPIVPDSLTSFNEPEYNELPMPSGPPRTRFQLQNFNTPVRMKLSKVLPRSAGDQDMIDVEETNFPELLFSAHVPAAEPTQANYPFVDLSPTPPGPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3V8</accession>
    <name>A0A194X3V8_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_735935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069228.1">
        <property type="nucleotide sequence ID" value="XM_018220059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3V8"/>
    <dbReference type="GeneID" id="28829785"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735935"/>
    <dbReference type="InParanoid" id="A0A194X3V8"/>
    <dbReference type="OrthoDB" id="10447657at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="24638" checksum="D714893FCCDFA8FB" modified="2016-10-05" version="1">MSSGRESQSLNEGNIGSGGNDGAKLLVMSGIYYVPRSEKAPKLTPAEEASAIQVVPKQPDQAPVQFAGKTPLPSTRKGKTRKPITHWTLSELEFLMEIIEEKLCKHRRLLQKEDWVEITDEMNKHFQGQRVRAGDKLSTYGKFAENNRAYPVRNANAVHSYATKKNTKGPLYNELCHKYLTGGGKRFTGTNIAGGKGTWAGKTPLVDDTGSGEDGEWQDDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X493</accession>
    <name>A0A194X493_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_124254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069234.1">
        <property type="nucleotide sequence ID" value="XM_018205182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X493"/>
    <dbReference type="GeneID" id="28814908"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_124254"/>
    <dbReference type="InParanoid" id="A0A194X493"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="18689" checksum="D3FEF82E4BF091AD" modified="2016-10-05" version="1">MSSGVVNIGRDVRAERVVERPRTVSELGNLARTMLTPTEVPYSVGFEQFENCQVVTLDISDSSATKCLKRNILNSSQKEFKSLLLGTRSAQRKKRQSRRCMPMVNVSRGPGVESNVLKYLVGMQRKPITRPVPSLRLAHLQSSLRSCSGPQEKSITLGQFTVEILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4P5</accession>
    <name>A0A194X4P5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_648309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069496.1">
        <property type="nucleotide sequence ID" value="XM_018212008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4P5"/>
    <dbReference type="GeneID" id="28821734"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648309"/>
    <dbReference type="InParanoid" id="A0A194X4P5"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="495" mass="53688" checksum="FA2A56B68C3AFD13" modified="2016-10-05" version="1">MAITSKWNPSRVAKSVWEVLEQGWYLGFTAFGGPPVHFKIFHDKYVNKLGWIAEQMYQELFAVCQAFSGPGSTKMYYCLNLIHFGFLPAVLALIIWTLPGALGMYGFAVGVSHIGESLPRQAYALLSGLNAAVVGIIALAAVQLAQKAITDKMTRILVVLGACAGLLYNALWYFPLLMMLAGCTSVIFDYRVLHPAAKWITSLRRKRKQTNPEDQDLELPTNVKSEQDKPAASSKPATAATAESKSDNQPSATVALETVPEPRIIPAARTLNISWQFGSFVLVNFLLLFIAIMVLRGTLPLKPLLFNLFSNMFLAGTIISGGGPVVIPLLREYVVSEGWVSPRDFLLGLAIVQAFPGPNFNFAVFLGALTAVFGGYNAAAGVLLGYLGIFLPGIITVHGTMGIWSAIRGKRWVKSALRGINAAAVGLIYTAVYRLWQIGYVDEGFEAGKSLGDDPWWVVVAVTSYVGGMWFNVNAPVAIVLGATMGLIRYGVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4Z9</accession>
    <name>A0A194X4Z9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_686039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069611.1">
        <property type="nucleotide sequence ID" value="XM_018215195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4Z9"/>
    <dbReference type="GeneID" id="28824921"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686039"/>
    <dbReference type="InParanoid" id="A0A194X4Z9"/>
    <dbReference type="OrthoDB" id="3880401at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="252" mass="28178" checksum="A4ED957261C0898E" modified="2016-10-05" version="1">MASNEVPEFLYHVKRTVTDYYEDNSGATRMVDILGTFTQLAAAKQAAYSALASEGYLRDDFEKYEAKHEVEAEEWKHPDGVVTFAKAPAGQEFEVRLDTKPNEMKLKGDAAGEVEGHLHYVLQTTINYNNDRIGGIQNTEVEGTYLTRKAAFEAAKTCLLDEEVTKESFAEYDEKEQFKGEWPYGDECLVHAVGETGENFLVSVKAQPHHHKGHGCTHHGGKKCECSCTHAEGGCKHKQCKHEDCDCSKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X554</accession>
    <name>A0A194X554_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_735988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069287.1">
        <property type="nucleotide sequence ID" value="XM_018220071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X554"/>
    <dbReference type="STRING" id="149040.A0A194X554"/>
    <dbReference type="GeneID" id="28829797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735988"/>
    <dbReference type="InParanoid" id="A0A194X554"/>
    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="28"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="26062" checksum="8FD903FB3BFF3129" modified="2016-10-05" version="1">MVDYNENVYGRRGLDGRSHIPALPFWVALIRIAQFILALITLILAGYASGVFGAGYFPGYGMTFFTFAWTVLFLLYIFVTPLWFPQVYLYWAHLGFEIATVIFWLVTFALLAQEAAVWNAFSTADAELNTALSEAGSNAIVFPHWDQAIKATKAAAGIGALTWLLFIVTLVVFSFLLHKHRVANGSTGFGISRPAAAPTDVEAKPATTTEKIPTTTAEPPLELNDVNGAQHQVSSPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X573</accession>
    <name>A0A194X573_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_783409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069569.1">
        <property type="nucleotide sequence ID" value="XM_018222678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X573"/>
    <dbReference type="GeneID" id="28832404"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783409"/>
    <dbReference type="InParanoid" id="A0A194X573"/>
    <dbReference type="OrthoDB" id="3437109at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="28137" checksum="610E37E382C24F27" modified="2016-10-05" version="1">MALADEVFCDMKATVRYCDEPIQKDMIKLDVTGSAKKLPVLRSFYTNKENKAWSYASCHTQLIRLGYRMGFEKSATSYAIRLQCANLLCATVAPAQAGKILGQKGPSVLQKSYASTISGIDVQSLYQKKPMHTSDIAKMTRLKFSNNLRKGAPYRLLRKERLAALQTEEVQDLSRRRERGTVSKQQLDVAKARAKREYIAKLRQDYFERSSNEYAELALDDLGPCRARVVELMYCHCYHMTFGHVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5P1</accession>
    <name>A0A194X5P1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_686154</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069749.1">
        <property type="nucleotide sequence ID" value="XM_018215221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5P1"/>
    <dbReference type="STRING" id="149040.A0A194X5P1"/>
    <dbReference type="GeneID" id="28824947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686154"/>
    <dbReference type="InParanoid" id="A0A194X5P1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ15394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="389" mass="43027" checksum="C8A63938794AF395" modified="2016-10-05" version="1">MENVGPTQTDYEPHPLTDEHYDASAKALTELTTRAENHNQPPKSHIHGSSSTTESHAWLSKFLPPSTIQAVENKFHLGNYVLDRETGEKTWEAMSVYVRVGMHLLYYGSAQEEALHWKKTLDLLKAQSEKMGKEYDSPESKQHIVPFIQSFDLESGLHEMVQPDPNAYSTFNEFFARQIRESARPVAEPENDLVTSSPADCRLTAFPTVDLAKKYWIKGFGFTLAALLGDEQLASQFEGGSIVIARLAPQDYHRWHAPVSGTVRGIKDIPGAYYTVNPQAINEPGTLDVFCENKRSVMTLERSSTGAPIAIVAVGAMLVGSIKYVGGVDTIGAEVRRGQCLGAFYYGGSTVIVLYPPGEVVLDEDLVRHSTELGMETYVKVGWRTGMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X815</accession>
    <name>A0A194X815_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_669792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070614.1">
        <property type="nucleotide sequence ID" value="XM_018213126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X815"/>
    <dbReference type="STRING" id="149040.A0A194X815"/>
    <dbReference type="GeneID" id="28822852"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669792"/>
    <dbReference type="InParanoid" id="A0A194X815"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="498" mass="51185" checksum="0FFAEC234B73E052" modified="2016-10-05" version="1">MFGSTQPKPAGGLFGTTTSAPQAGGVFGSTATTQSQSGGLFGSTAASSQPGGLFGSTATTTQPQAGGLFGSAQPAQSGGLFGSTAASTQPQTGGLFGSAQPAQSGGLFGNTSSSQPGQTGGLFGSSQPQQSGGLFGNTNTSQPTQTGGLFGASNTASQPQQTGGMFSGLAGQQNQPTGGLFGAANPTQPAQGGLFNNMNNQNQNKPSLFGSSAQGAGQLNQNTGQGLFGSTLGGGLSLGQSNQQQQTVPGVRVDPSQIRGTTRFNDLHEELQKEITKFDDIIQAQIQLKNQCDAIMTAHDSQLAQVPTDVEFCRRKLIGVENAADSDVQAISLAQKLVKTDAEHAKLSFKAIDNLKLPPQYHNSNIWSSKAVSGSQTQSNGDAEAQDIVSFFSSTADEIASTLSSYQKHMIEIEQHLRNVEASSVSQQSEFLARKNGAGIGQDDPIEQLTGALTEFESSLLGVAGRVGGAREGLQSLQLGKFTGPPTTTRSGYRNGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X896</accession>
    <name>A0A194X896_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_648126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070372.1">
        <property type="nucleotide sequence ID" value="XM_018211992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X896"/>
    <dbReference type="FunCoup" id="A0A194X896">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X896"/>
    <dbReference type="GeneID" id="28821718"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648126"/>
    <dbReference type="InParanoid" id="A0A194X896"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="201"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="358" mass="40181" checksum="A8A94D715770C242" modified="2016-10-05" version="1">MLIGLCGGICAGKRTVANYLVQHHGFTHLYLRQDTENADILKALTINGHTKQNSDVSSRTLPDQPTAIEDQSTFRNSEELLDFVTKRWRERWVTTDIHTESILDKLLRRPFFILVSIDAPVSIRWKRFQERLQRTHSSSESLTLEEFLLKSDEHLYNPNSGLLPLISRATVRLLNTSSDLAHLYATLGKLDLTNEDRLRPSWDQYFMQLASLAAHRSNCMKRRVGCVLVREKRVISTGYNGTPRGLKNCGEGGCPRCNEGQGSGVGLGTCLCIHAEENALLEAGRERIREGAILYCDTCPCLTCSIKIAQVGISEVVYSQGYSMDTETAAVFKEAGVHLRQFVPPPNGMIHLEKQSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8X9</accession>
    <name>A0A194X8X9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070597.1">
        <property type="nucleotide sequence ID" value="XM_018213124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8X9"/>
    <dbReference type="STRING" id="149040.A0A194X8X9"/>
    <dbReference type="GeneID" id="28822850"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669776"/>
    <dbReference type="InParanoid" id="A0A194X8X9"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="358" mass="39598" checksum="EB67DA17FC374F72" modified="2016-10-05" version="1">MPRKLPWQTSTSTAVARTKRPALPSSKRQKVATKNGDSDDQADLRPSVRKERADLEDPRSSSPPPDPPPESFMIEGMDDDDKYRMVEDQFLTIAQKFTVHLHAAEYKRQQKIAKTRNAETISSISRPVAGKMPDQTKRKVEAVERAKAQKSVLEGLIGKKVGDADISDDSDDGDGLPYVGTSLHGLMDSPRRKATSLSKVSAAATTRAAAGYKQSAQARRMSLGSPQFRLTARSSQSAKVLEDDATESSADDGDLDAAPKLESRERKPTLVQKLNLVSEKRDSKTSDLLLSYESRAPRSKHSTSDFIDVPKTVKTEISSPPPKQRERMSRSELARARRKKEEEEEKAKAKLDIIPGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA73</accession>
    <name>A0A194XA73_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_669130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071017.1">
        <property type="nucleotide sequence ID" value="XM_018213068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA73"/>
    <dbReference type="GeneID" id="28822794"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669130"/>
    <dbReference type="InParanoid" id="A0A194XA73"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="15034" checksum="7C32A350625BACF6" modified="2016-10-05" version="1">MAFVQLWGQQRTSRSCLNDEDDFGVGVEQLCNLLLGRRSDWGRFVVMWKWWPLDRAGPLERNHEARAMTPDQKKEEQIGSDKLIANKGSAAAQFDLLISQLICSPIFAILDSKQTEYTEENSRYSPADRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAN0</accession>
    <name>A0A194XAN0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_585760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071559.1">
        <property type="nucleotide sequence ID" value="XM_018209339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAN0"/>
    <dbReference type="GeneID" id="28819065"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585760"/>
    <dbReference type="InParanoid" id="A0A194XAN0"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18404" checksum="956DF2D40D36D8B2" modified="2016-10-05" version="1">MDSAADKEERKREAATRWLTLSYNRVAQREFRRTRKEHLRSLEQAQKEQSFEQSEEIECLRCQNDELRRENEALRAQIYRQPSSHGMLSIQMAVRPLGSDGRQYSLSPSISAASIEFRHDANGGSIIDIFDITTLDTSIRRPLSFVIPAILYGTCIRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAQ5</accession>
    <name>A0A194XAQ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_547040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071598.1">
        <property type="nucleotide sequence ID" value="XM_018208257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAQ5"/>
    <dbReference type="GeneID" id="28817983"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_547040"/>
    <dbReference type="InParanoid" id="A0A194XAQ5"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="308" mass="33783" checksum="6D20180498DDE4AE" modified="2016-10-05" version="1" fragment="single">TTTASTIVSVLAVISVALRFWTRRLIKAGYGPDDWWILVGLVFMLSTGAILLYGVRKDPDGGQAINRDDPHFDFTPHTTYLKTSFIAATLYFSVVTSIKISILFMYRRIFPIDEFFLQSQIVGALVLIWWLIGSVLTIVSCIPVNRLWIGPSASGYCFDFNIYWMSMGAVELVIDTLLLILPVRMVLGLQLRRQQKVLVAGIFALGGFVIVTGLVRVILGYRPGSQNVAFARAELWSAVHTGTAIVCACLPTLRPLIKRASIIASSLKRIYGSSSSGGQDTTASGSMGSNAESRNRGPTEVLTLKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBI3</accession>
    <name>A0A194XBI3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_684545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071880.1">
        <property type="nucleotide sequence ID" value="XM_018214904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBI3"/>
    <dbReference type="FunCoup" id="A0A194XBI3">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBI3"/>
    <dbReference type="GeneID" id="28824630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684545"/>
    <dbReference type="InParanoid" id="A0A194XBI3"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000003">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="345" mass="38720" checksum="5E6A69D6F6F67AF7" modified="2016-10-05" version="1">MDPQEESVASPASEPRKQKKKKVLLMGKSGSGKSSMRSIIFSNYVAKDTRRLGATIDVDLSHVKFLGNLTLNLWDCGGQDAFMENYLSQQRAHVFSNVGVLIYVFDIESRDFDRDLLTYRSIIAALSQFSPSASVYILIHKMDLVVPTQREDIYNDRVTLIQSKSDNFAATPFATSIWDQSLYKAWAEIIHDLVPNLDKIETHLGRLGAIIMAEEILLFERSSFLVVSSWASSIGKQNPTTDRFERLSNIIKNFKQTTSRYTGLPKSSEQFVLMEMKLQTFSMFVIKFTTNTYLAVVLPPGETTFNCAMENCYIARTEFEDLDSPAKKSADRGATTSGATTSAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBP5</accession>
    <name>A0A194XBP5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071933.1">
        <property type="nucleotide sequence ID" value="XM_018214912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBP5"/>
    <dbReference type="GeneID" id="28824638"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684593"/>
    <dbReference type="InParanoid" id="A0A194XBP5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="57" mass="6805" checksum="A8D059C7AD2FC6DE" modified="2016-10-05" version="1">MFKKNPDKRVSNQRILSKLAISNDKFYNSARQFIRDLHSFNNDEKARSRFAETGHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD75</accession>
    <name>A0A194XD75_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_684033</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072464.1">
        <property type="nucleotide sequence ID" value="XM_018214801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD75"/>
    <dbReference type="STRING" id="149040.A0A194XD75"/>
    <dbReference type="GeneID" id="28824527"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684033"/>
    <dbReference type="InParanoid" id="A0A194XD75"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ18109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="546" mass="57496" checksum="14E34CE5B6A9B0AD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEM4</accession>
    <name>A0A194XEM4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isotrichodermin C-15 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_706352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072995.1">
        <property type="nucleotide sequence ID" value="XM_018217519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEM4"/>
    <dbReference type="STRING" id="149040.A0A194XEM4"/>
    <dbReference type="GeneID" id="28827245"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706352"/>
    <dbReference type="InParanoid" id="A0A194XEM4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF199">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268142" evidence="6">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="48043" checksum="B7055426FAD37A49" modified="2016-10-05" version="1">MCFDGVHNVIAGLGLAFIALLSECSLSFAHIDAWTEIFQGRPGHPQYQKDPVWWGKQPGQAESLLSAGPRDHSRMKKILSHGLTQRALKLQEPTVQKYVALLIDKLKDQVAESPAGAVVDMVPWFNYTTFDIFGDLAYGESFDCLQHSKYHPWITILFKSVKAASFIIAARFYPLIDFLLMKCIPPSLKQMAKDHISLIEHKHNKDKGGMTLEEIQATLVFLTTAGSETTATALSGTLNYLAAHPDKMQILVEEIREAFKKEEQINCQTTQTLEYLNAVLNEGLRLCPPIPVMLPRVVPNHGDTICGAWLPGGTSISLQQWTLFRDPTYFHESGSFIPERWLPASTEKASPFFHGQRQAVQAFSVGPRSCMGKHLAWAEMRLILCRILWTFDVEAAGKAVKWEDLKTFLLVEKIPIEFKPRVRHNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEP5</accession>
    <name>A0A194XEP5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_732911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072582.1">
        <property type="nucleotide sequence ID" value="XM_018219742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEP5"/>
    <dbReference type="STRING" id="149040.A0A194XEP5"/>
    <dbReference type="GeneID" id="28829468"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732911"/>
    <dbReference type="InParanoid" id="A0A194XEP5"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="14">
        <location>
            <begin position="592"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ18227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="780" mass="87273" checksum="9B3961EAE698C3E2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEX1</accession>
    <name>A0A194XEX1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_774731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073051.1">
        <property type="nucleotide sequence ID" value="XM_018221975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEX1"/>
    <dbReference type="GeneID" id="28831701"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_774731"/>
    <dbReference type="InParanoid" id="A0A194XEX1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41992" checksum="FCC29B30A260D32B" modified="2016-10-05" version="1">MRERRNKLNASSLRIDFRPFIRLLLNAERSLVVSPAQPQPHAKPCLLCFNFLRVVDLGVINGSQHARKVKAAPKRESSLEDKILDPLTALGLASNIVQTVQFTSDLISKSREYHVDGSLVKQLELEAITVNLRTLSQDLVVPGSGGVRAAKTERQLRELCIGCQEVSDELLVTVQSLKVRGFHNTWTSFRQALKSVWKEEKIKTLEERLERYRRQIDTTLLISIREGIDRSINSLSKSERDCKQIAFAPDSGNGVKQWQSELLNKVHQSDWNLHAERRMIQFSTRLSASAMKDRDDLIKQQILARLHFDSINDRAERIPKAHQNTFDWIFHAPESSHDLASHVSGNLTSDMGTTQPSSARSAVYPLWAGW</sequence>
</entry>
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                <person name="Labutti K."/>
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            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="756" mass="84955" checksum="187FA2769546A705" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFM7</accession>
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    </evidence>
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    </evidence>
    <sequence length="300" mass="34601" checksum="ACB81A059CBDA1AB" modified="2016-10-05" version="1">MGVTGAGKSSFISLCSDETVEVGHDLTAHTSRVDVYSFKYNSSTTVYLIDTPGFDDTSRSDTEVLQDLAAFLTRSYVQKVKLNGIIYLHRITDVRMQGSAKKNLMMFKKLCGKDALKNVILATTMWSLVDREKGAEREAQLLSTPEFWGWMKDQGSTVMRHSGDRRSAVEIIDHFVEQNVPMTLDIQDQMVNQNRDLDQTSAGQELQSELIRERERFQAELRQVQEDMQEAIKERDALAEEALKEVRDEYMSKIGELSQQGEELKISMQKLHEANYKELRDHMIEQVESHRRRMHHPIQR</sequence>
</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGT2</accession>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073694.1">
        <property type="nucleotide sequence ID" value="XM_018219606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGT2"/>
    <dbReference type="STRING" id="149040.A0A194XGT2"/>
    <dbReference type="GeneID" id="28829332"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731741"/>
    <dbReference type="InParanoid" id="A0A194XGT2"/>
    <dbReference type="OrthoDB" id="5339038at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016864">
        <property type="entry name" value="UCP028035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028035">
        <property type="entry name" value="UCP028035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="915" mass="103073" checksum="AE6C337AEF0D2ECA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHP4</accession>
    <name>A0A194XHP4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_695417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074090.1">
        <property type="nucleotide sequence ID" value="XM_018216760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHP4"/>
    <dbReference type="GeneID" id="28826486"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695417"/>
    <dbReference type="InParanoid" id="A0A194XHP4"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="16"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="465" mass="52591" checksum="C2C801395358F4EA" modified="2016-10-05" version="1">MFAVDQKLLFKIDFFILTFGCLAYFTKWLDQANLSNAYVSGMKEDLKMYGTQYNLAVTCFQVGTILGGIPSNLLLTWVPPRILLPGCELLWAILTIFTYRVESYTQLYPIRFFVGFLEGSSFVGIQYVLGSWYKRNELGKRTAIFSCAAYVGTMISGYLQSAVLAGLNGKHGIAAWRWVFIVDGCITVLVGIYGFIFFPDTPEATTAFYFTEEDKKRAKERLVEDGREPRGEFSWNMFSRVVKTWQLYVLTILWMFWNTTVGKVANTVMQLWLKSDKQHTWSLYQVNNIPTAINGWNIVMILLANIYVDATGRRMVVVMLNLILLLFGTICLIAWDIPLGLKIVAYMFAGTDGPLSPIYMAWANILCSNDRQLRALTIAIMNSCGAALTTVIQQFLYPVTDAPRYLKGFPASLAFIVGMCGWVFVVRYFELRAPKKEIEDGEVVESESTEEVAEKKVDVSVALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHX4</accession>
    <name>A0A194XHX4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2og-Fe oxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_640940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074091.1">
        <property type="nucleotide sequence ID" value="XM_018211687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHX4"/>
    <dbReference type="GeneID" id="28821413"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640940"/>
    <dbReference type="InParanoid" id="A0A194XHX4"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="215"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="378" mass="42345" checksum="0E4F18ED8E335018" modified="2016-10-05" version="1">MADILTSPPPPENKVYFHSGSTPTYRLVTHTSAPITAIPTLDISQISSPDPSIRLSLAKELVSACSSCGFFYLTGHSLSPQLQTKTFDVMKRFFDLSIEEKMDVHVQKNPAIRGYEPRGETKLDPRTSGDIKESFTLGDCPLEPEQSYHLKTGHPPPPSLTRPQNIWPSSVPWFRAGIYEYYNAILPIAMQLVRLLALGMGVDEEGFVREFFEFPITGMRPLHYPPVEGEGDGEGNVGLGAHSDFSYLTLVLQTPSLSALEVLTPTGQWISVPALPNTLVCNVGQYLERQSNGRFLAAVHRVRNKSGEERYSLPFFLTMDHDADVEILVKDGEERKFEDFNVGDLYIRRVLAARGKHPTSIKYRDVLESEWKYDLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHY1</accession>
    <name>A0A194XHY1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2og-Fe oxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_459461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074089.1">
        <property type="nucleotide sequence ID" value="XM_018207673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHY1"/>
    <dbReference type="GeneID" id="28817399"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_459461"/>
    <dbReference type="InParanoid" id="A0A194XHY1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="368" mass="41634" checksum="4A8ED90D28443195" modified="2016-10-05" version="1">MASTTTSTLTASAETSDNTTLLKLSSAEGPVYRHIKNIPLRDARPDEIPIIDLSTISSPSLSSRQSIATQIHQAATHNGFFYVKNHGIASSTIENAYSSALEFFRQSEDIKQKVDATNSKSMNGWKAPKTQRINASESIDVRETFSFRYNPVYDPEVPDEIPENVKNTVTIDDFCWDQTYNLPHFKDHSLDYWRETVKLARTLTRIFALALSLPEEYFDAKIKYPDAGVAINYYPPMPASSEQAGENSIGSHTDFQLFTILWQDNNGGLQVLNRDGEWINAAPIEGTFVVNIGDYLQRITNDRYISTVHRARNLSGKERISMPLFFGFNLDEMCGLLEICVDEEHPARYEAISCRDWVQKRVKAMHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIE5</accession>
    <name>A0A194XIE5_MOLSC</name>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_464947</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ19899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018207709.1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
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            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="39632" checksum="C46B4D41A5DA8219" modified="2016-10-05" version="1">MFAWAVSDAALLHATLILTAKHWISLGGSRRFIESTLYQHKSEAIRLVNERLADPLAAVTDGTVSAVGILVILECLEGSNEAALVHLGGLEKMVHMRGDLHTPHMNGLAQRIILLADIHTANANNVKPRFQRIQESPEDKESNENGTPPPSGAMVQPDPVIGSFYRELGLDAPLIKMFTDLHWLSSMMSNSARRRGAVNANVLNRGITEAEKYIDTMLRGGRLDNHQTTKGIVAGKAFVVLSGYIYLYLLLRRIEVSSRIYDWMVDLLKEDLKNIQHVMRKAYPPELLFWILFLGASASIGRRELEWFKKELLVGKESLGLSAWSSAKAILMKFSWVEGWNEEASERFWNELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJR0</accession>
    <name>A0A194XJR0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">LY89DRAFT_610620</name>
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    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074825.1">
        <property type="nucleotide sequence ID" value="XM_018210555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJR0"/>
    <dbReference type="STRING" id="149040.A0A194XJR0"/>
    <dbReference type="GeneID" id="28820281"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_610620"/>
    <dbReference type="InParanoid" id="A0A194XJR0"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="489"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="802" mass="88509" checksum="DE4FA948E0BE06C2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK80</accession>
    <name>A0A194XK80_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1671-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_682974</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074552.1">
        <property type="nucleotide sequence ID" value="XM_018214610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK80"/>
    <dbReference type="STRING" id="149040.A0A194XK80"/>
    <dbReference type="GeneID" id="28824336"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682974"/>
    <dbReference type="InParanoid" id="A0A194XK80"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="246"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="482" mass="53788" checksum="4BD1479D48118F0C" modified="2016-10-05" version="1">MEDPEQITCPFCGFRAEGDYQIMLHMETLHPENGESPFVAKENASIAALVSLQDEEDVQYVNCPVDGCGEALLLTELDNHIEMHEEEQSHSPGESDESSRSPKRLKIEPRVEASFDTKLSYALRNLDEDDGHLAHEKSSHDVQTAAKNTWKSILKMPDSASKAESKVVPIANSSKKRLGKSEIGPHAHEKQMPAWLVKLLEEDGALKMGNRLDSGGKIRRVQYSPNQTAGIVPVLAQLLEQNETTSYAYLCDPAVKHVSKLRREGGFCGYRNIQVLCSYIIGTRSQGHDSFGDKVPTIFDIQEYIESAWDIGINSQGRIETGGIRGTRKYIGTPDAQAMFCVLGIACSAQAFKPKKGSNSQPGSELLFTAIENYFINGCTDYDPKVRRTSLPPIYFQHPGHSMTIVGFEKQKDGSRNIIVFDPMFHDAADVTKLIGTEFTHRYPGDLLKAYRRGVKYLRRYGEFEILKLTPPKNQQSGEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKD2</accession>
    <name>A0A194XKD2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_640419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075025.1">
        <property type="nucleotide sequence ID" value="XM_018211666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKD2"/>
    <dbReference type="GeneID" id="28821392"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640419"/>
    <dbReference type="InParanoid" id="A0A194XKD2"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18323" checksum="2C86E33CC4230620" modified="2016-10-05" version="1">MSSTLQPLPIRLAQTLGLTSSLLLAGQTLTLSTFLIPRLLDSPTPLMLRQWNAMYQSGKKQGPPFALVSALSYWYLAYHSSSSSKTTAYAVAGALAIGIVPYTLLFIKGTNVKLLEKVGETKSLGKLEEVTEVGLGNQSAHALVDWWGMLNLGRGMLVVASGVLGTWTALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKZ8</accession>
    <name>A0A194XKZ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_579286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075161.1">
        <property type="nucleotide sequence ID" value="XM_018208993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKZ8"/>
    <dbReference type="GeneID" id="28818719"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579286"/>
    <dbReference type="InParanoid" id="A0A194XKZ8"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="68"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="36602" checksum="82558134F2B7AA67" modified="2016-10-05" version="1">MIQFISTLSLVEYNQPPPKAVPAQPGTPDPFREFFLQLQAHATPGLSSWGKSPAKGKIPGLRKDDTAKKQECVICVEEKPLQHFPKITDSCQHPDQICLVCVQNWLAREADNTDWDKIHCVACKEIVPYNHMKRLMTKAAFEKYDQYSRNATLSKMPNFRWCISSSCSSGQIHEIDTDGYIFYCGACYTKTCVIHNVPWHEGETCTEYDYRQDPKVKAAEERASKIEIKGSSKPCPGPGCKVNITRNGGCEHMKCELIFELWDARVNENADSRQVRDVIMSSVGSVWRISIRFGRMGIRSMRRVASCTRRICQIISIIHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL44</accession>
    <name>A0A194XL44_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075253.1">
        <property type="nucleotide sequence ID" value="XM_018219404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL44"/>
    <dbReference type="STRING" id="149040.A0A194XL44"/>
    <dbReference type="GeneID" id="28829130"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729717"/>
    <dbReference type="InParanoid" id="A0A194XL44"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004689">
        <property type="entry name" value="PRK06031.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43218:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43218">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="231" mass="25525" checksum="60A6758171568441" modified="2016-10-05" version="1">MSDPAPYFTGPTTHSWQEILPSGSNTGSPWQYAYPACLPDQRILMLPIRQTAPNEAVASLLTTHAAIDVADELGEYLAEIVREYNPEVIVGLPTLGLSVARTVAKALGHKRYIALGYSRKFWYTDALSTQVSSITSPDHLKKIYVDPHTVPLLTGKKIFIIDDAVSSGKTLKMSWDLLESSNVGCEVLGAGVIMKQGENWRGQLGPDREEKLNWVFNSPLLRRVDGGWDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLL6</accession>
    <name>A0A194XLL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_779394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075017.1">
        <property type="nucleotide sequence ID" value="XM_018222286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLL6"/>
    <dbReference type="STRING" id="149040.A0A194XLL6"/>
    <dbReference type="GeneID" id="28832012"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779394"/>
    <dbReference type="InParanoid" id="A0A194XLL6"/>
    <dbReference type="OrthoDB" id="3925971at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="37276" checksum="6B83AFA79F464DA0" modified="2016-10-05" version="1">MPAPGQFLPRKSSAHRIACIALYRALLKQCPHIPLPDDVPLRGNTNPITHFIQKAFRKNVYHTSPKLVVTALETGYAACSLLHHAATSSPESPNPSLLQVHDLLRAQSNSYVASKLACPPKPPPGRPASKAYPGAPKAVDIRPLPKEKLTGRRHVPKLVAVHGIFPFLRFRKPQSAYLSRVLTQKVKRKLRRFERLAEMEGAKEMGEWEDVWEDTVSSVGHLKNESRRDSEWEDGEKGVEKGDYKPFKLDSQSWGEAPHYARLATWSALAKEGARARRLGSKMLEIIDQEQKLWEEERRERRHLKNLERKRRKLESLAQEGKSKNSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM89</accession>
    <name>A0A194XM89_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_729996</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075559.1">
        <property type="nucleotide sequence ID" value="XM_018219427.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XM89">
        <property type="interactions" value="1363"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XM89"/>
    <dbReference type="GeneID" id="28829153"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729996"/>
    <dbReference type="InParanoid" id="A0A194XM89"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1308"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1655"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ21204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1887" mass="209899" checksum="461FB4B65AA4A93F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPB5</accession>
    <name>A0A194XPB5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_576764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="663"/>
        </location>
    </feature>
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        <location>
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            <end position="191"/>
        </location>
    </feature>
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        <location>
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            <end position="238"/>
        </location>
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            <end position="415"/>
        </location>
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            <begin position="533"/>
            <end position="577"/>
        </location>
    </feature>
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            <begin position="25"/>
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        <location>
            <begin position="97"/>
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            <end position="130"/>
        </location>
    </feature>
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            <end position="190"/>
        </location>
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            <end position="236"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="536"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22090.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="697" mass="75012" checksum="22FF8020E6731C38" modified="2016-10-05" version="1"> </sequence>
</entry>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28816951"/>
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    <dbReference type="InParanoid" id="A0A194XPJ4"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    <dbReference type="Pfam" id="PF06395">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="51961" checksum="FD35EC79FEF32DC5" modified="2016-10-05" version="1">MDPITITTSIFGLLKATETIAGYLGPYVSAARDTSQIVRQVHSEVVYTRTTLLALEGLIKNISSVPVRRAALIQVDQLVAVFTDGVLLFSELEASLPSPPSAESSTSRLPILSRLKWARKESTFTSLFTRLQGFKGSISLMLTILQSDSDSRAAENQKQLSENVAALLESNRSLYLRLLNLEDALEVRTIRAIDDGNASSMKQQPDESIAGPTFDFENDLETSRVYRKAQRESMDFSFRSSIARTNAWSVFSGLSLSDVSNISVIALPLYREDIENAQHYGCTSPPAEPITTPTTARGPKSLCEECLELELRLSRIPGIPEYFEKVTDDHLEEDPLTRLILVLRQGLPLLMILEKFQGFEHCTEVGSDYNDPLKLPKAATYKFISTCVHQDGLRLAPDKCFSVSELFGHDSTGFMKVSSIPCTESSSTFQILSYRLLGSLIGYLTYSIFKMTLNVSTSQPTFLSKNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQB2</accession>
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        <submittedName>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQB2"/>
    <dbReference type="STRING" id="149040.A0A194XQB2"/>
    <dbReference type="GeneID" id="28821209"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636274"/>
    <dbReference type="InParanoid" id="A0A194XQB2"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0520">NAD</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="10"/>
            <end position="349"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="38953" checksum="896F09A7B1C3BCC1" modified="2016-10-05" version="1">MADIPEKMLAAQVVEFHKPYKIQEVPVPGKNLDENDMLVKVAVGSLCHTDGMVLEGIMGTKLPCIGSHEGAGTVVKVGSAISEFKVGDRILVNLTYHRCRTCADCKGPEQDTQYCANVGGYLGVSRDGSFAEYELVDGRECCRLPDNVSFQSAAPLACAGATVWGGLVRAGLKSGESIAIVGGGGGLGHLGVQFAKALGLRVIAIDARDEGLALAKECGADTTVDARKGKEKVVEEVKKVTNGKLADATLNVSDHESAAATGAAVTKMHGILLQIAQPTNVSVPFEEFVFRDIRVHGSLICSRGECQKMLEVVSKNNIKVKTNAFKGIKEVPKAVELAHSGKMQGKPVILIDERAIEDEKRSGLKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQF6</accession>
    <name>A0A194XQF6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="16 17">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_018214095.1"/>
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        <property type="interactions" value="1176"/>
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        <property type="reaction ID" value="UER00187"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:glycolytic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="435"/>
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    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
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        <location>
            <position position="159"/>
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        <ligand>
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            <position position="168"/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">LY89DRAFT_298520</name>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="403" mass="46668" checksum="9C575B6ACCA06241" modified="2016-10-05" version="1">MYDNNHLDQTQRERERRILKRLTKRKLRTCRTLRKQLLMLRLKEKLYAQDTHCIVELLSDSADIKMPQNNETSGIVPSDIHQTADLCVLKQTLENPSKSSSDSLWTLVDIDDASESKIVEDNSPTCIDHFQLKIGHTKIKREDCEPHIVCKRQAGMMSVDSEPEVLCRNTWLAKDEDDNYMLTVSFSIASLFSPLDVEFDTRIAVSKSYKDIFTSARRPARIEGLQPSSTAQCVHAIGIKIDSKAWLGTSPRNNWMPLHMHVRVLETANSAGKIRLCVNVTLGSPRKWNCEQLVWLPFDYSFQHLPDWRRRLNRLSAEREPAPQVTPRAAISNLMQIVERYQALDWSHNARQNLNKRNKDNASMEKGQIRPSLIEYQVWYNLDPQPRPQESDSEEVLEEEMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQU4</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">LY89DRAFT_694479</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="3 4">CBS 120377</strain>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
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        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgoN"/>
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        <property type="entry name" value="PAZ"/>
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    </dbReference>
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        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="560"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="919" mass="101841" checksum="A3B86BCE5DC349F6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRS5</accession>
    <name>A0A194XRS5_MOLSC</name>
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            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_680938</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018214174.1"/>
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    <dbReference type="STRING" id="149040.A0A194XRS5"/>
    <dbReference type="GeneID" id="28823900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680938"/>
    <dbReference type="InParanoid" id="A0A194XRS5"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
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    </dbReference>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_8"/>
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    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="266"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="504" mass="56320" checksum="3CAC5FBA88A131F8" modified="2016-10-05" version="1">MKNSVIPLDSGFSSREDVQPSGGSVAFVESSSFEESPNSIPHHPMGIRPAGNQYTASIISRNRIGTFQAIPDEIIAIILEFFESRGLRLIGATCKFLHALTRSEDLWKTLFIESPESKSGLFQWRESWLATYSNLTEKQLSKVRCDNVFSDALYRPFLCTHTPLTPYATNIPRGNAIPRFDNLSPTEFSEKWSDKPFILTNPVREWPVYQTWDTDALLQQYGGVKFRAEAVDWTLSSYVDYMNNSSDESPLYLFDRGFVEKMGLTIGKDKPKPSYWIPECFGEDLFAVLGDKRPDDKWLIIGPARSGSTYHKDPNATSAWNAVLRGSKYWIMFPSTGSSPPPPGVYVSEDQSEVTSPLSIAEWLLGFHAEARKTPGCIEGVCNEGEVLHVPSGWWHLVVNLDASIAITQNFVPRSHLPGVLSFLRDKPDQISGFKKDVADPYGTFIEGMHAEHPKLLEQALAELERKAEGKKRKWGAAVGKDEEETNGAGFSFGFGDDSDEEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSA3</accession>
    <name>A0A194XSA3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_776979</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077535.1">
        <property type="nucleotide sequence ID" value="XM_018222094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSA3"/>
    <dbReference type="GeneID" id="28831820"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776979"/>
    <dbReference type="InParanoid" id="A0A194XSA3"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ23180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="109" mass="11951" checksum="6CEFDCEB165F1435" modified="2016-10-05" version="1">MSSTTRPPATSSTNAPSGEKSYFEQQREVLLKEIGVSFEHVLANINKLNRSLEGVIAVGNEFSSVEALWSQFENVMAKDPDAEAETHAGEGEEAEQDEETEIREHGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSC5</accession>
    <name>A0A194XSC5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_306635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076987.1">
        <property type="nucleotide sequence ID" value="XM_018206602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSC5"/>
    <dbReference type="STRING" id="149040.A0A194XSC5"/>
    <dbReference type="GeneID" id="28816328"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_306635"/>
    <dbReference type="InParanoid" id="A0A194XSC5"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="207" mass="23299" checksum="2BE1B25E5F5D43D5" modified="2016-10-05" version="1">MNAPSNQIMMPVGPHHDLLTEKIAIDCEMMRSNIGQVLGRVSVINYNSQTIFDTFVCYPQPIHVTNTSEQYSGIRWSDIDPQNGAQPFLQVQAQLVEIFRGRIVIGHDIEKDLRVIRMDLQTHTLRLEGVYQIETPVKLDMKTRDTQKYTGYSQYAIGPHGPSLKTLALEVLGRPIKMGRISSVEDAVATMAVYRNAEAGIEQEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSD1</accession>
    <name>A0A194XSD1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077565.1">
        <property type="nucleotide sequence ID" value="XM_018213988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSD1"/>
    <dbReference type="STRING" id="149040.A0A194XSD1"/>
    <dbReference type="GeneID" id="28823714"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679999"/>
    <dbReference type="InParanoid" id="A0A194XSD1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="97"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="37875" checksum="1E8A92D27AF42258" modified="2016-10-05" version="1">MKTPEELLALADINPELEEIIKKYGPIPSLTADSDIPKIRQQLITRKRQMTALTESAEKKEKYVEEDRQIPVRDGTTIAVRIHKPKNPAKDGCPIFVVYHGGGFCLGGLDSEVLLCRRFTELGGIAVNVDYRLAPEHPFPVPPQDAYDALKWTAENFTQLGGNPKKGFLVGGISAGANFTAVVTHLYRDDKLSPPLTGAYLSIPACMAAELCPEKYKSVWLSREQNKDAPILNNDSMGLFEKLYNPDPKSKYRTPMLFKSHKDLPATYFQICGMDPLRDEAFIYEDILREENGIKTKVDVYPGLPHGFWSYFPEAEFSKKLQEDCIGGMKWLLEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSP9</accession>
    <name>A0A194XSP9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_680007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077578.1">
        <property type="nucleotide sequence ID" value="XM_018213991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSP9"/>
    <dbReference type="STRING" id="149040.A0A194XSP9"/>
    <dbReference type="GeneID" id="28823717"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680007"/>
    <dbReference type="InParanoid" id="A0A194XSP9"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836790" evidence="2">
        <location>
            <begin position="16"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="35641" checksum="A065540569193808" modified="2016-10-05" version="1">MGFFLEFLWRQLFVWLPTPNYDFSGQTVIITGSNTGLGREAARHIVRLGAAKVILAVRTPAKGEAAAAEILESTKKTSSIIEVWELNLSSSASVKAFAKRAQGLARLDAVILNAGILTTQFALVEGEESSIVVNVVHNTLLALSLLPKLRESAAKTGLRGRIAFVGSDLQYLAKFAEGETPGNTFDVLRVEEKADMDDRYKVSKLLLACAVRAISAESPVSDKSNVIITYLTPGACKSDLFRDPMGGFQALALAIGKTIIGRSTEVGSRTLVNAVRPNQDVKVHGQFLMDGKVASAGPKINSPEGKKLEEKFHKELYDKLEQLSPGVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSV4</accession>
    <name>A0A194XSV4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_728138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077740.1">
        <property type="nucleotide sequence ID" value="XM_018219235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSV4"/>
    <dbReference type="FunCoup" id="A0A194XSV4">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSV4"/>
    <dbReference type="GeneID" id="28828961"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728138"/>
    <dbReference type="InParanoid" id="A0A194XSV4"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46544" checksum="389D57DFDF51156B" modified="2016-10-05" version="1">MDNFGDGIAKAVLENFETWERKRKPLDRSSQKDEGLSEKTKPREWVPLSGIVAQRNDKISCVAAATGMKCLPKDKVSKAQGIVVHDWHAEILTIRSLNRFLLEECLDLALSRKAFSEYVRFRSDEEKTETHFQPFALQDGTQLHMYCSEAPCGDASMEITMAAQEDSTPWAHPPSLISGDDENTLHGRGYFSALGAVRRKPSRPDAPPTLSKSCSDKLSAKQSTSLLSSVTSLLISPQNCYLQSLTLPESQYSEVACTRAFSSIGRLAPLHGKDWGDGYSFRPFKILTTSSEFGYSRRQALGSREALVPSNIASLWTPRTSETIIGGTQQGRKQFSIKGASQVSKRRMWVLAVAIANELYLSSPAILSSLKVEKYIEVKNGELLKKRKEVKEDVRSTLKGWQRNNDDESWKDTEVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT55</accession>
    <name>A0A194XT55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077686.1">
        <property type="nucleotide sequence ID" value="XM_018214010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT55"/>
    <dbReference type="GeneID" id="28823736"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680098"/>
    <dbReference type="InParanoid" id="A0A194XT55"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="76" mass="8120" checksum="28B9041FFA041AC6" modified="2016-10-05" version="1">MTSMVGVGTFPPQSSSPQKQSRPNLLRLSQPASLPQPQPQPQPLLSRGGYALYLSFPPSERWRNSANGSGAAAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT69</accession>
    <name>A0A194XT69_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_693460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077599.1">
        <property type="nucleotide sequence ID" value="XM_018216637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT69"/>
    <dbReference type="GeneID" id="28826363"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693460"/>
    <dbReference type="InParanoid" id="A0A194XT69"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="30462" checksum="ECA1EADB3DF164D6" modified="2016-10-05" version="1">MTRTPVYFLSHGGPNIMYEKDYPVYPTLQKIGKEITQKVKPKAIVVFSAHWQGEPNVIEINTSENTELIYDFYGFPANYYKETFPNKGSPEVAQKVTDALTKAGIKTQGLRRGLDHGVWASFKVAFNEETNPLTVPVVQVSLYANEDPAKHIALGKAVQSLRDENICLIMSGMAVHNLRDMRFGMNGVQPYAKSFDEALRAAVEAPIEERDGKLIKLLWRKDARPAHPTFEHLLPIHMGAGAAGGDRGKRLWTLAEGSFSWAQFRFGDVPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV63</accession>
    <name>A0A194XV63_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_604708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078570.1">
        <property type="nucleotide sequence ID" value="XM_018210369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV63"/>
    <dbReference type="GeneID" id="28820095"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604708"/>
    <dbReference type="InParanoid" id="A0A194XV63"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050829">
        <property type="entry name" value="CorA_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47685:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORT PROTEIN CORA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="724" mass="83630" checksum="145D7D20CA2484A2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX11</accession>
    <name>A0A194XX11_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">9-cis-epoxycarotenoid dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_634317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078662.1">
        <property type="nucleotide sequence ID" value="XM_018211386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX11"/>
    <dbReference type="GeneID" id="28821112"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634317"/>
    <dbReference type="InParanoid" id="A0A194XX11"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="560" mass="63596" checksum="45A5D255EB3EBF3F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX15</accession>
    <name>A0A194XX15_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_679696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078964.1">
        <property type="nucleotide sequence ID" value="XM_018213929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX15"/>
    <dbReference type="GeneID" id="28823655"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679696"/>
    <dbReference type="InParanoid" id="A0A194XX15"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="61" mass="7122" checksum="980CE4707DFD0ECB" modified="2016-10-05" version="1">MEFKAVGLEDMIVLCDEDGEIHSHYDGIKELLDSEDDTYREDRGSGRKIIRQECRFVEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX71</accession>
    <name>A0A194XX71_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_634472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078742.1">
        <property type="nucleotide sequence ID" value="XM_018211389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX71"/>
    <dbReference type="GeneID" id="28821115"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634472"/>
    <dbReference type="InParanoid" id="A0A194XX71"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="33727" checksum="5E4667BF247341D5" modified="2016-10-05" version="1">MASEKEGTLPFPIPGIDKPCSTWYKTIGDLHSGTTPVVVVHGGPGLTHDYLLQLSELNSLYGIPVVFYDQIGNGKSTHLREKSGDESFWVEELFWRELENLVVGLGIGDSWDLLGHSWGGMMGATFAGRTPSPKGLRKLILGNAPAYMSAWVDAYGRYLEAMDDDVKAAIKKGEETGERESKEYEAAMEKFMAKHCLGEKAPPELAVSFEWAGKDETVSKTMSGSSEFVVTGNMKNWSAVEASKLISVPTLVINGVNEGATDEAIKPFLDNIKGVKYVKFHHSSHMGLYEEKELYLKTVGEWLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX74</accession>
    <name>A0A194XX74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_663132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078747.1">
        <property type="nucleotide sequence ID" value="XM_018212688.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XX74"/>
    <dbReference type="GeneID" id="28822414"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663132"/>
    <dbReference type="InParanoid" id="A0A194XX74"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="588"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2126"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="588"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="746"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2209" mass="245532" checksum="606A6CF7FA65C78C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2W3</accession>
    <name>A0A132B2W3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_661792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061091.1">
        <property type="nucleotide sequence ID" value="XM_018212622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2W3"/>
    <dbReference type="FunCoup" id="A0A132B2W3">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B2W3"/>
    <dbReference type="GeneID" id="28822348"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661792"/>
    <dbReference type="InParanoid" id="A0A132B2W3"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1174" mass="127850" checksum="2CB8E4EBDF0C0439" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B440</accession>
    <name>A0A132B440_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_702552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061517.1">
        <property type="nucleotide sequence ID" value="XM_018217263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B440"/>
    <dbReference type="GeneID" id="28826989"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702552"/>
    <dbReference type="InParanoid" id="A0A132B440"/>
    <dbReference type="OrthoDB" id="4224637at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="23707" checksum="DFD0F816706A0779" modified="2016-05-11" version="1">MASHLSSPSAKKYFLTPWTLTTPTHPALTFQRATPSHISHWLPLVTNPANNIHMDDVKSLLWTPSDISAWKTRTITNYNKSLTTYHQLAVLIAENGKFVGYGDLWLLENGNFNVGVVLDVSVQGRGLGRLCTAVLVQLGFEVGEKGVEAGTMKVNGGFRGVMRSLGVVEEEKLVVAEGRGILAELSYTVDREKWRDVELDVVWGEGTLGRVDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5A8</accession>
    <name>A0A132B5A8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_660371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061950.1">
        <property type="nucleotide sequence ID" value="XM_018212549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5A8"/>
    <dbReference type="GeneID" id="28822275"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_660371"/>
    <dbReference type="InParanoid" id="A0A132B5A8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="532" mass="58450" checksum="7F3475BA33CB4958" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5E1</accession>
    <name>A0A132B5E1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_742695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061818.1">
        <property type="nucleotide sequence ID" value="XM_018220857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5E1"/>
    <dbReference type="STRING" id="149040.A0A132B5E1"/>
    <dbReference type="GeneID" id="28830583"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742695"/>
    <dbReference type="InParanoid" id="A0A132B5E1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ07463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="421" mass="46884" checksum="F9536639310E82CB" modified="2016-05-11" version="1">MDTKSSSAHESYLVLGAGCFGASTAYHLKQTLPASSVTLLDRGPFPNPSAAGHDLNKIIRADYQDIFYMKLALEAQQYWRRDPIYRPYYHESGMLYAEDKGMARANLDNLNAVGEKHHAEILTPEETRAKFDGGEADRALESVISAAVKEGVIYNSSGVSTLCIDESAICTGVRTEDGAELKANRVILCTGAWTPKLLLDTAPHNKALHIGDRMVAAGAIQCTASYPPDQMYKFKSMPVMFNGCDHTEGECIPPTPQKMLKFNYEVSFTNKEFHDGSGQTISVPPARLDQSTWSQAVPQGLKKDEIHTVVDHVFGKWIDGIKIEDYRICWDAVTPNQDFIIDRHPNCKNLYFAGAGSFHSWKFLPTLGKYVLDMLQGTLDAEKASRWAWDRPNQGSALPAYVPRRDLKEIPGYEDVAKHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Z7</accession>
    <name>A0A132B6Z7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_347700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062368.1">
        <property type="nucleotide sequence ID" value="XM_018206897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Z7"/>
    <dbReference type="FunCoup" id="A0A132B6Z7">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6Z7"/>
    <dbReference type="GeneID" id="28816623"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_347700"/>
    <dbReference type="InParanoid" id="A0A132B6Z7"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="606" mass="64854" checksum="F01B1A5AD232C9C4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B701</accession>
    <name>A0A132B701_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_630641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062476.1">
        <property type="nucleotide sequence ID" value="XM_018211243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B701"/>
    <dbReference type="FunCoup" id="A0A132B701">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B701"/>
    <dbReference type="GeneID" id="28820969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630641"/>
    <dbReference type="InParanoid" id="A0A132B701"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="34"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="451" mass="50337" checksum="35FC48B5D187F03E" modified="2016-05-11" version="1">MARRRTKKRTHVGASNGPTGKAVPTSKASNSPKSMVIRIGAGEVGPSVSQLVKDVRSMMEPDTASRLKERRANRLRDYVTMAGPLGVSHLMLFSRSDSGNTNMRLAITPRGPTLHFNVESYSLCKDIRKALKHPKGGGKEYLSPPLLVMNNFTSPASEAESNQNIPKHLESLVTTIFQSLFPPISPQTTPLSSIRRVMLLNREPTKENDGTYTLNLRHYAITTKATGLSKPLRRLNAAEKILNSQKSGKSRKGGVPNLGKMEDIADYMIGGDGEGYMTDATSGSEVDTDAEVEVVESRAKKILSKRQKDRTREAKSKSGRSGVEKRAVKLVELGPRMKLRMTKVEEGVCNGKIMWHEYIHKTKEEVKELDKKWEQRRQEKEARKKIQKENVEKKKKAKGVGAKADAEDEDDEMDVDEWDSEGLEGDGEMELNEEMEDRGEWEDEEEEIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7C7</accession>
    <name>A0A132B7C7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_725168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018218958.1"/>
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    <dbReference type="GeneID" id="28828684"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725168"/>
    <dbReference type="InParanoid" id="A0A132B7C7"/>
    <dbReference type="OrthoDB" id="3506997at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="524" mass="58678" checksum="91E186456037FF06" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7R0</accession>
    <name>A0A132B7R0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_676821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062756.1">
        <property type="nucleotide sequence ID" value="XM_018213626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7R0"/>
    <dbReference type="STRING" id="149040.A0A132B7R0"/>
    <dbReference type="GeneID" id="28823352"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676821"/>
    <dbReference type="InParanoid" id="A0A132B7R0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="224"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="53681" checksum="4A5A325253B0ADF1" modified="2016-05-11" version="1">MTFEEYSKLATRDFEVLVADSDCRHEILCPRCYTGRAEDREALPRRFSGTSSFQICVYILLISANLGALALWFKTTPQMGDCVRPVLAYSPAKADDAIHYEKRRLVTEIDANVFSGPPRPAHDEAWAHLIEPIAIKISKQQLDLIGEDSIEFADKSGYLAETSLYHELHCIGRSALCTLSDQEYSDHCLEYWREAAMCRGDTYLTPFFWRDGQPVSRVWSDRDHDKELSFPQIEAFFKAKKNKIFLANEFTYAITSPVVKISLIVFYRRIFIFNPFRRASDILITMCVLWGLATILGSATQCRPLSKSWNPTIEGKCFNVRQIRLRHTRSKYLPCYLYSLSTDENGMESQTTLARAAGSDGYILAGSIYRIYTITLMDDNDIPFWTLVEPSIGLVCGCLPTIRGLFPAYRVSRSTKGTAASNNLPEPHRATNSYNDQLQYIKMVSITEILGNPSNDDDKAHGGEIRVNTVVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8M6</accession>
    <name>A0A132B8M6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_691028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062958.1">
        <property type="nucleotide sequence ID" value="XM_018216216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8M6"/>
    <dbReference type="FunCoup" id="A0A132B8M6">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8M6"/>
    <dbReference type="GeneID" id="28825942"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691028"/>
    <dbReference type="InParanoid" id="A0A132B8M6"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="66"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="38427" checksum="53351DCCB122444E" modified="2016-05-11" version="1">MADSQIEDDVALETPAADVFIAPSVNPDLLFTGASYTHYSAVPHSLQPTPNPDAASSSEKTIPGPACALGVDEAGRGPVLGPMVYGLFYLPLPLSDPLLRTTHHFDDSKVLTPTVRSNLMEKLCTPDTDLYTQCGWAVDVMSARDIGANMMKPAGTYNLNAQAMDATIALIQGVYKRGVNVKEIYIDTIGNPATYQKKLERVFPTAKVTVAKKADSLYPCVSAASVCAKVTRDAALEVLFESYVKKGEGDGDEEMSGTAEAGQETWGSGYPSDSKTTGWLKRNMDPCFGWGAECRFSWGTAKDMLELKGMAAKVEWPVEEDDETSRLTDFFSAEKEQDGDELGTWFGRPVGVDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8W9</accession>
    <name>A0A132B8W9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_327211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063201.1">
        <property type="nucleotide sequence ID" value="XM_018206758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8W9"/>
    <dbReference type="GeneID" id="28816484"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_327211"/>
    <dbReference type="InParanoid" id="A0A132B8W9"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="168"/>
            <end position="602"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <location>
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        </location>
    </feature>
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            <begin position="13"/>
            <end position="27"/>
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    </feature>
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        <location>
            <begin position="46"/>
            <end position="57"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="617" mass="68368" checksum="E4EF90B653BEED29" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9M5</accession>
    <name>A0A132B9M5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_659483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28822243"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
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    <feature type="domain" description="RRM" evidence="11">
        <location>
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        </location>
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            <begin position="172"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="380" mass="40876" checksum="0A9466E7D961813E" modified="2016-05-11" version="1">MPPQIKQDLNRSGWETTDFPSVCENCLPDNPYVQMIKQDYGEECKICTRPFTVFKWKADRTSRSKRTNICLTCARLKNCCQCCMLDLSFGLPIVVRDAALKMVAPGPQSAVNREYYAQEHEKEIEDGRGGVEAYEKTDEKARELLRRLANSEPYFKKQRRIGPADGEGAGGESSTSTALASNGPGPIRTRDSRGSPSTRGSAVRGGRGGARGGRAFPSAAQLPPGPRDIQPPADQSITSLFVTGVEDDLPEFKIRDFFSPYGKLRSLVCSHMSHCAFVNYATRESAEAAAEALQGRAVIAGCPLRVQWGRPKPIGTMDKEERIATGREGRSAFASSGPSNSHGTSQGAIAAPPKDDLASMSAVAAPPGASDVPYASLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA91</accession>
    <name>A0A132BA91_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_724351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA91"/>
    <dbReference type="GeneID" id="28828616"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724351"/>
    <dbReference type="InParanoid" id="A0A132BA91"/>
    <dbReference type="OrthoDB" id="5428321at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="201" mass="22876" checksum="70C032206EB43BDC" modified="2016-05-11" version="1">MALPRPSNQDRARWRTKCREKLSKHIKSKLGISIDPSEVRLITRVEDPYSWQSLPVRTHLFKKNLSKHSIGAYMELCREVGISFKAVVKENILFTRPAANFTNRIAELEAENSRLIGEVNKLKDTAAAESTFKRDAEEAANQLTVVLHTAELENQHLKRDIQKWATIAEDFRVSTADSHQIVNEASLVLEKLKSLLPSICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAJ4</accession>
    <name>A0A132BAJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_564959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="37"/>
            <end position="48"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="10547" checksum="0D01B4EC19DD6FA9" modified="2016-05-11" version="1" fragment="single">MSTSADASSKPANEPTKTPANSSQKTTLALPEAPHNAATQLDMSSGSTTVKLDHLGPVVVNVDGTMSRISNWDKMADIEKQNTLRIISKRNEQRLEAL</sequence>
</entry>
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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            <end position="22"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="10649026at2759"/>
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        <source>
            <dbReference type="EMBL" id="KUJ10026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="156" mass="17790" checksum="E0FAF5552B38A684" modified="2016-05-11" version="1">MAIWEKQSGEIKAHVKVAEEQSDDATADELQKMLKNCNKLWMNKAVKVLHDTMKDETPIPRVADIFRNDLDKLAERVDSLIDTLNSVGEEGLEAELLSGLQKLHNLSDGLSALERRFEEPTQRDLRIFDDEMEMYGGELVYILKQLLSTTKSKAEK</sequence>
</entry>
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    <accession>A0A132BCE0</accession>
    <name>A0A132BCE0_MOLSC</name>
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        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="A0A132BCE0"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KUJ10038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="586" mass="68638" checksum="E75B1CD76FA20E2C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCE5</accession>
    <name>A0A132BCE5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206354.1"/>
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    <dbReference type="InParanoid" id="A0A132BCE5"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
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            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
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        </location>
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        <location>
            <begin position="171"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="300" mass="33442" checksum="E5DC534A0E3EAE47" modified="2016-05-11" version="1">MRSELNLHEKHDTARSYALLPTTERHDSIDQAAELTSERPMHFSSQLFSSHEAKDTILNTLDLDYPFASSSKIPLYNLSQENDAPPTFQLNQEQPHLVNEKLQTESRRFVSPSLDTNSFYPSQESVLDLLAEASTVEILEMQGSHNNKGLEDKSSIHVKRTPSAMAPRPGQSKSSRNLRIRNSQLSQWPICVESESEFEDDTEIGIPHEKSDNFQGFDRPPNSTSASQPETQTSFSVAGEKYAETNAVRSTSANSPALHNTAEHTPASQSEKRRDFSAIPGSQTLLRFLPGGGGWVTEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCV2</accession>
    <name>A0A132BCV2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_690475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063842.1">
        <property type="nucleotide sequence ID" value="XM_018216104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCV2"/>
    <dbReference type="STRING" id="149040.A0A132BCV2"/>
    <dbReference type="GeneID" id="28825830"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690475"/>
    <dbReference type="InParanoid" id="A0A132BCV2"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288134" evidence="2">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="446" mass="49050" checksum="0CBDF809ABE97D34" modified="2016-05-11" version="1">MVGLKFATVAALSGLVIATPATIGYKGDWKSKIKNVVVLVEENRSFDTFAGGLSYTSGINGLLHHNYCNSMNASDPAQMGDVCAGPRANDVAPDDPNHSISGVNMQIFSTWHPDESKADSRIEIENMRGFVTEQSVAYDTLNKTRAAEVLNYYTSDQIRVFGTMAENFVLFDRWFAAVPGPTNPNRAYITSGTSHGHGKNDNAFNVYGLPQRSIFQQLSEAGITWMNYQNSTTGPGLGFNPDAAFYNWTYTSGAYKTNIAPLDQFYADAKAGTLPQFTYINPECCDYQSFHPPSPITLGEQFIKGIYEAVRGSPQWDETLFILTFDEHGGFGDHVPPPTGVPAGDDVLYTETAPDGKNITFNFERLGVRVPTLLISPWVQKGYVEHKGSNNGGEYTHTSILGFLQSLWGLDTLTPRVSYSSTFEHLITDDLRTDTPATLPDPFPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDL5</accession>
    <name>A0A132BDL5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_276909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064122.1">
        <property type="nucleotide sequence ID" value="XM_018206422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDL5"/>
    <dbReference type="GeneID" id="28816148"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_276909"/>
    <dbReference type="InParanoid" id="A0A132BDL5"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="213" mass="23958" checksum="91A5DC631AA74661" modified="2016-05-11" version="1">MSVLFCCFSFNRLCITYYSHPSFRSHLMATSRAPEVDVVAALFLTLTWVTTALRCYVRGFMAKSFGIEDWFAILAQLLFTLTAIFVLEGISHSLGKHLIDISLQNLAPAMMYWFSTELAYTMTTGVLKLSIAFFLLRIATKKSHRIILYSIICLVALLTIAYFLFLVFQCKPVSYFWEQFGGETGICLAPAIVGDMTYTHSGVNAFCDVILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE73</accession>
    <name>A0A132BE73_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="2">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064499.1">
        <property type="nucleotide sequence ID" value="XM_018220601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE73"/>
    <dbReference type="STRING" id="149040.A0A132BE73"/>
    <dbReference type="GeneID" id="28830327"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740537"/>
    <dbReference type="InParanoid" id="A0A132BE73"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="597" mass="66544" checksum="09481B994891C3CB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEF6</accession>
    <name>A0A132BEF6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_710703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064744.1">
        <property type="nucleotide sequence ID" value="XM_018217851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEF6"/>
    <dbReference type="FunCoup" id="A0A132BEF6">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BEF6"/>
    <dbReference type="GeneID" id="28827577"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710703"/>
    <dbReference type="InParanoid" id="A0A132BEF6"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="478" mass="50849" checksum="A9DF229B261A4280" modified="2016-05-11" version="1">MAEGMASKAQSKDLFDKLKREPANKICFDCQVQNPTWTSVPFGIYLCLDCSAHHRNLGVHISFVRSTNLDQWTWDQLRMMRVGGNELASNSIPKTKDIKTKYTSKQATDYKTKLKELAEEYMAKQGTNIVTTDGLKKDAPTQGTSTPKGDPSKAFFDSWAEPTIKRPTPPISRTATPPVVGRTPSPFLNAGASNGNGNGIARTASPLANAAPVASRTTSSAALRKTTTGAPRKANVLGAKKTKLGAKKVTGDVIDFDAAEKKAKEEAERIAKLGYDPDAEVDSTPKAAATKTADLPKIASPSPVSPGRSGYGSKTHERTNSELERLGMGMGRLGFGQVGGSKPAAAAPKKMGGFGSVGPIKATQEDDDEKYARQKFGAQKGISSDEFFGKGAFDPNAQSEAKSRLQGFEGATSISSNAYFGRAEDDAPAEDYGDLESAAKDFVRKFGVTAGDDLENLTQVLGEGASKLQGAIRSYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEP5</accession>
    <name>A0A132BEP5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_787383</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064679.1">
        <property type="nucleotide sequence ID" value="XM_018223067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEP5"/>
    <dbReference type="GeneID" id="28832793"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787383"/>
    <dbReference type="InParanoid" id="A0A132BEP5"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ10324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="613" mass="69878" checksum="2592A3497E6422E8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSV5</accession>
    <name>A0A194WSV5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Urea carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_625418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065395.1">
        <property type="nucleotide sequence ID" value="XM_018211074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSV5"/>
    <dbReference type="FunCoup" id="A0A194WSV5">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WSV5"/>
    <dbReference type="GeneID" id="28820800"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_625418"/>
    <dbReference type="InParanoid" id="A0A194WSV5"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="7"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="125"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1239" mass="136080" checksum="B90ABBB653888AAB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTH3</accession>
    <name>A0A194WTH3_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_759958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221491.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194WTH3"/>
    <dbReference type="GeneID" id="28831217"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_759958"/>
    <dbReference type="InParanoid" id="A0A194WTH3"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="44646" checksum="0E3D08B8772128A2" modified="2016-10-05" version="1">MAPTTAEVEKADRLRLEGNELYKENKLLKAIQKYRESAKLVPNDAVPLGNLSAAYYEIMDKDMPTQPDFPNGLLEYLTPIFIDTAKAMKKLKGRFQIEAMVGDALDLCESLRFILYHDAADPSATAAIGTRPKEFPVLFDRVHLSNIPDYMCGNLSACLFVPPLPKSISSSHWQQCCLRKGNLFDSYETYLAEYQRITDPTMLKQLTQVKMISEFDDYQPMVEYLTYKVADILPMSHGKLLPKAPFFRWFYALFFRLALPFEYDGSGVNLIIYTPLNLTVLFHLLAHLKTLGYPAHCLSDVLLAIIENKVVTTSRSPRSSPALPEDVEYDNPERKLSTAPFSYEMKTLAVMFQNQHLHSHCHRSPYFLKAFTDTHSPCLTMEHTSSIIPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUJ2</accession>
    <name>A0A194WUJ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065980.1">
        <property type="nucleotide sequence ID" value="XM_018220434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUJ2"/>
    <dbReference type="GeneID" id="28830160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739052"/>
    <dbReference type="InParanoid" id="A0A194WUJ2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="8639" checksum="4A09F6BD53598C46" modified="2016-10-05" version="1">MYSDSKTPKKRVSVRKQAPISRETKETQDTFDEKDEDKATKESEKEAALNKETKEETKKDYLLILLGIGFWLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV24</accession>
    <name>A0A194WV24_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_226777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065869.1">
        <property type="nucleotide sequence ID" value="XM_018205998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV24"/>
    <dbReference type="GeneID" id="28815724"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_226777"/>
    <dbReference type="InParanoid" id="A0A194WV24"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443851" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="482" mass="53401" checksum="E170770FF6B2E55B" modified="2016-10-05" version="1">MRFHLDKAFLLTAALFSFSAQVSGSPAPHLKGKGSIEIRDGVTHTIFEHEATGASLDFVKNSGFCETTPGVNQYSGYFSVGQNMSMWFWFFESRHHPHSAPLAIWLNGGPGCSSMIGLFQENGPCQFYNGSSTPSLNPYSWNEYANMLYVDEPIGTGFSYGTDIVNGTVSAAPFVWTLLQAFFAQFPEYECRDFGLFTESYGGHYGPEFAYYIQQQNDLIDSGDLDAEEINLVALGINNGWYDAIIQEREYISFSINNTYYPLINTTIADAYMASYYNSCLPALIPCNSTTGELTECHAAHVACNAMDNYYGQFYNQTTDPYDIRQSGDNVFPPETYLNYLYDPEIQKRIGAKSNYSECSDAADAPFEDFADSQRSFLPALSSVVQSGIQVLIWAGDADSVCDWFGGFASVNAIDFDGQDEFVDTDVQNYTVDGVASGTYKTVDNLSWIRVFASGHEIPAFQPKLALQAFIQTMKGESVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV39</accession>
    <name>A0A194WV39_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_624895</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065889.1">
        <property type="nucleotide sequence ID" value="XM_018211055.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WV39"/>
    <dbReference type="GeneID" id="28820781"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_624895"/>
    <dbReference type="InParanoid" id="A0A194WV39"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="240"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1556"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1864"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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            <end position="903"/>
        </location>
    </feature>
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        <location>
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            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1578"/>
            <end position="1590"/>
        </location>
    </feature>
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        <location>
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            <end position="1605"/>
        </location>
    </feature>
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        <location>
            <begin position="1616"/>
            <end position="1647"/>
        </location>
    </feature>
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        <location>
            <begin position="1661"/>
            <end position="1683"/>
        </location>
    </feature>
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        <location>
            <begin position="1700"/>
            <end position="1726"/>
        </location>
    </feature>
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        <location>
            <begin position="1727"/>
            <end position="1742"/>
        </location>
    </feature>
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            <end position="1815"/>
        </location>
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        <location>
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            <end position="1933"/>
        </location>
    </feature>
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        <location>
            <begin position="1989"/>
            <end position="2000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2009" mass="215932" checksum="1BD6CD50AA3D6A21" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVM4</accession>
    <name>A0A194WVM4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_219329</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205926.1"/>
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    <dbReference type="GeneID" id="28815652"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_219329"/>
    <dbReference type="InParanoid" id="A0A194WVM4"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_A1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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            <begin position="20"/>
            <end position="556"/>
        </location>
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            <end position="433"/>
        </location>
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            <end position="478"/>
        </location>
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            <begin position="490"/>
            <end position="533"/>
        </location>
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        </location>
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            <begin position="490"/>
            <end position="507"/>
        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12015.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="556" mass="57463" checksum="4BFF38ABE26EB988" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX86</accession>
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    </gene>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXB0</accession>
    <name>A0A194WXB0_MOLSC</name>
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        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28830134"/>
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    <dbReference type="OrthoDB" id="5325862at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KUJ12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="293" mass="32066" checksum="67B8B1C927DC03E9" modified="2016-10-05" version="1">MAFGNSIFKYTSSLFSTNTTTTLPDYDSPPDYSSIDTTTKDVSFLKSQALEQSFIPTSILQIQAQGKVAYASIGSPAKELETPIIDPNNANIGPKYTSIRAQKNSGNCVLVQGGKHGQEGVQVASTTYKWGPGKPPVIRISKTLQPVEEKEVQGFSNHETDEFELHSKSMFKRTVFFDSQRWGHFEWRYADRKERAIADTSGNKSINNLLVLEKVVGNGHMEQRIKVAQLVRGEGTRTPGTSKNSAGNGGQLEMCLEGSDGPLIDDVTVVVSCLVMLKKEIDNLRGAEIAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY12</accession>
    <name>A0A194WY12_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY12"/>
    <dbReference type="GeneID" id="28823043"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672938"/>
    <dbReference type="InParanoid" id="A0A194WY12"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024530">
        <property type="entry name" value="QSregVF_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12843">
        <property type="entry name" value="QSregVF_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="29328" checksum="78EC30E88F230B56" modified="2016-10-05" version="1">MKAKTPRQTARFSPYAISSQPLYQLSSQLSPEHQDEEYTAPTGNATPDSSQSLSDSYQFDFSKHKGRLRPTLKAALAARASSQPTPSKSGLARAILTPLSLSNLQSSGPLDKYELPSRPREHVLPFGKFKGTKLKDVDGTYLQWVAEQICEGAMTLGPTLTNALTSMGYTTSYNSDLAPLKADYPYPDLRTAPTVFREGGHEDIFWSRITIEEAIVEAEVGKEVRQTADKHKLKFDVPTRIGLCVLFRRAYRALFRDGIVSFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY50</accession>
    <name>A0A194WY50_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_593268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066877.1">
        <property type="nucleotide sequence ID" value="XM_018209741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY50"/>
    <dbReference type="GeneID" id="28819467"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_593268"/>
    <dbReference type="InParanoid" id="A0A194WY50"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27452" checksum="360F0E6FDBFB85A1" modified="2016-10-05" version="1">MSECCVRGSLWQGTPSGRETTLSKNKSYRTGSNKDVTILFIHDAYGWTFRNIRILADAYAKEVDATVYVPDFFGGEVLPPEILDDPSQWHTLDFPGFMARNSKSVREQEILACAQALRSQYKRVGAAGFCFGGWAVFRLGAKEHANLVNCISTAHPSLLEKSEIENVKVPVQIIAPEIDPQFTPGLKELANSIIPTLGVPYDYQYFPGIEHGFATKGDESKIAEYSAVKRAKGSMVAWFRLWLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYH5</accession>
    <name>A0A194WYH5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067350.1">
        <property type="nucleotide sequence ID" value="XM_018213332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYH5"/>
    <dbReference type="GeneID" id="28823058"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673099"/>
    <dbReference type="InParanoid" id="A0A194WYH5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="22534" checksum="7474FCE50C7E49A5" modified="2016-10-05" version="1">MECGTIPCIPDLYKQSNFLNESLLLPLGLFTLSLERHSHENHSKCHRILLQPLKSSIQPQLSIPPPRATLQSAQLVIIQSKARLRWDIITRAGEVRDKQENTIFAVREKVLNEESKVRQDREERFLQMRVGLLIEEVSLRKRLFEARWKEKIDRDESEGEKLSEAKRDVPVANEENGLDKAILKDSTKVVDDNGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZH1</accession>
    <name>A0A194WZH1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_754000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067701.1">
        <property type="nucleotide sequence ID" value="XM_018221302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZH1"/>
    <dbReference type="STRING" id="149040.A0A194WZH1"/>
    <dbReference type="GeneID" id="28831028"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754000"/>
    <dbReference type="InParanoid" id="A0A194WZH1"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="428" mass="48350" checksum="C6FAD0E7EFE6573C" modified="2016-10-05" version="1">MLSSTPEAALLDRWLCFAGPKGPDNAAIHSIGEWVSLTPHLIAKSVPVRWAATCLLDSIQAFVKRGDQNHATAVESNAKALQCIRNGLGSSKSRPCKSDVMLAIKLLFVAEIFIDSDAGNYYRHMKGLNDILCDAFRQQSAYDEACQQIFYGNILGECIAAMRSGHDSKFYGSSWFDMSPPKTLVPGCPNFESAMKLVMQLQIEMTHFIRIVRETGERPNDNTVRQEAIELATKLYQLNLESLINELIATSMLEIISSSMTEVKLLFATSYTFSSTRIFNLVLNYWICRVLICGGIEILYSFLHFDEQRLNLATVQQHDVRTAEEIVMCFEYAYTYESQLCIMAMRFIMPLQTAFGAWHRLEKRALGYEYKEEDAQRAMEMKKWCISMCNKMGALFGQGRAMCAFEEMKTETLAGGPLFFGGILRPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZK5</accession>
    <name>A0A194WZK5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_756372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067397.1">
        <property type="nucleotide sequence ID" value="XM_018221374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZK5"/>
    <dbReference type="GeneID" id="28831100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756372"/>
    <dbReference type="InParanoid" id="A0A194WZK5"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF4">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267653" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="47"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ13042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="25621" checksum="D13DBEB85109682A" modified="2016-10-05" version="1">MAIFSKLLLLSLTVAGSLASPVEIKRDGVDILERNSDYNVIEPDFELGAHSVVKRTDPNYSQNYIASGANVQFSPNGNSFSVKFNTQSDFVVGRGWKTGDNTPIHFSGSASFTSGVGLLSVYGWSTSPLVEYYIIEDSKNPPQQGTIKGTFTSDNGTYTVWEHQQVNQPSIQGTSTFNQYLSIRSDGRSNGTVTLQNHFDEWAKYGMKLGSLNYQTISVESWGGAGSVSQTVTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZQ4</accession>
    <name>A0A194WZQ4_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_158267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28815199"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_158267"/>
    <dbReference type="InParanoid" id="A0A194WZQ4"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12791" checksum="4D02E769D346B2E4" modified="2016-10-05" version="1">MAHNTHIPWTLLSTHLKLTPTSRKPSGHTNLYPRYLPTQAGELAHFASIFARTIRTFSSTERSKHPSPTPIPSPSPSSLIISDRTAAKNRENSLPLLPHHIHQPRVPGIRRQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZW4</accession>
    <name>A0A194WZW4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative galactose-proton symport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_687388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067512.1">
        <property type="nucleotide sequence ID" value="XM_018215488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZW4"/>
    <dbReference type="GeneID" id="28825214"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687388"/>
    <dbReference type="InParanoid" id="A0A194WZW4"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="29352" checksum="875A601F0F8D5064" modified="2016-10-05" version="1">MAPLVPFWAQPSHPDIQKVLVNKEQEYTTKSISLVDLPPYALYAKFAFPPCTAAEKPTYATVQMGKDKHLNLNSDLVYINHSCEPSVIFDMASLSVISGPNGLKKGDELTFFYPSTEWDMAQGFDCFCGAQTCRGFISGAKNMAQEQLQGNWLNAHIRALLDERDGVVVSSNVENLAQNGNANGGFEEMKDATEQALQIALTQAKKVVDAAQRALDVYKSLYGREEATGQNGSAAQEVGAGYQVDGGINGGKRRGVTSRELSGEMGGDTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZZ9</accession>
    <name>A0A194WZZ9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_159282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067878.1">
        <property type="nucleotide sequence ID" value="XM_018205485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZZ9"/>
    <dbReference type="GeneID" id="28815211"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_159282"/>
    <dbReference type="InParanoid" id="A0A194WZZ9"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="585" mass="65815" checksum="F5ACD57E48B09E6F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X076</accession>
    <name>A0A194X076_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_709186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067714.1">
        <property type="nucleotide sequence ID" value="XM_018217742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X076"/>
    <dbReference type="GeneID" id="28827468"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709186"/>
    <dbReference type="InParanoid" id="A0A194X076"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF4">
        <property type="entry name" value="BLR0106 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="47351" checksum="39683F83DFE7739D" modified="2016-10-05" version="1">MTTSKSAPGLKSVIVVGAGPAGLLMSLLLAKQGVPVQLLDAGSTLDKQPRATHYGPPAVYELARAGIAEEVRARGFTPKTVCWRKKDGTYLAGLDGSILDGTPDRMVCLPLDRLGEILHKHILEQPTVDLKWNHKVTGLGQDEQKAWVDIETPEGPKRLEGDYVIGCDGANSQIRRSLFGDTNFPGRTWDEQIVATNTYYDFHKYGYEDANFIIDHEHWHMASRITNDGLWRVTYGEKPGQTREQLFERLPAKFEKILPGHPKPEQYKVVNFSPYKVHQRLTEKMRVGRFLLAADAAHLCNPFGGLGLTGGIVDVGGLFDCLIGIHNGVANDSILDIYDEIRRQKYLEIIDPISSENIRRLFGQDPDTVLETDEFLKLCKKTETDEAFSREFQNGINGIKYDFTQHYLKKELENGNSGVGLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0V9</accession>
    <name>A0A194X0V9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_148187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068188.1">
        <property type="nucleotide sequence ID" value="XM_018205374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0V9"/>
    <dbReference type="GeneID" id="28815100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_148187"/>
    <dbReference type="InParanoid" id="A0A194X0V9"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28525" checksum="03A4FA04F3828B82" modified="2016-10-05" version="1">MAPSPIPITIDHGNGGIPYTPHNATTLSKGWVTQPNNRGTLDILWTCASTLFICLWVQLHLNVPGPHERFFTQSLRRLRWLVMGALVPEVLLLSAGGQWASAERSVQDMKRLFPNSNSWTIVHGFYADSGGFVLQPRDSDPFPVSAKQVHYLVENAYIELPSITEKEILDKSKGDKFTKTIACLQTFWFITQCVARLIQRLPVSPLELQTCSIIICTVTTYFLWLYKPLSVQTPTVIPMSIPIGLVLKCAGISASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1G3</accession>
    <name>A0A194X1G3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_590937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068174.1">
        <property type="nucleotide sequence ID" value="XM_018209625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1G3"/>
    <dbReference type="STRING" id="149040.A0A194X1G3"/>
    <dbReference type="GeneID" id="28819351"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590937"/>
    <dbReference type="InParanoid" id="A0A194X1G3"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="22245" checksum="0C7DB82B3E349146" modified="2016-10-05" version="1">MSVNIGSSAQFSKLLTTSTIVVADFYADWCGPCKAIAPTYESLATKHSKPNRVTFTKVNVDNQQAISQQYGVRAMPTFMIFRSGSVINTIRGADVRGLTTAIESAVKLAGAGAPAYSSVGRTLGGPPARGTSVSRPFNFKKLIDTIIAFLGLYFISLFSFDAYAAAENSPFNVNRPAQPRVTPGTKLREKMPAPQTGKKLGTIADLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1W4</accession>
    <name>A0A194X1W4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_784172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068536.1">
        <property type="nucleotide sequence ID" value="XM_018222757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1W4"/>
    <dbReference type="GeneID" id="28832483"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784172"/>
    <dbReference type="InParanoid" id="A0A194X1W4"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18861" checksum="9DA16ED7C812F783" modified="2016-10-05" version="1">MPKNQSKNLSGDNAYLLPRSKGQPRRAMTKAQQKKLKVKGMKAINARNRSTFLQKSTLPQPPPVFTCFSNLPAELRLKVWEFAAENEIQLMHKHVHSSGDAFNSWLYPSLSWTCRDSRATVIACLSFKSWVWAGRLACRLRFSKWLFKRTLVWSTGWSYINRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X265</accession>
    <name>A0A194X265_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_590396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068449.1">
        <property type="nucleotide sequence ID" value="XM_018209592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X265"/>
    <dbReference type="FunCoup" id="A0A194X265">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="GeneID" id="28819318"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590396"/>
    <dbReference type="InParanoid" id="A0A194X265"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ14094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="539" mass="59578" checksum="C728A85291E9547C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2B2</accession>
    <name>A0A194X2B2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">LY89DRAFT_650084</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068696.1">
        <property type="nucleotide sequence ID" value="XM_018212092.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X2B2">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2B2"/>
    <dbReference type="GeneID" id="28821818"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650084"/>
    <dbReference type="InParanoid" id="A0A194X2B2"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900535">
        <property type="term" value="P:palmitic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <ligand>
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        <ligand>
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</entry>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="SEL1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
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    </dbReference>
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        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="862"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
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        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
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        <location>
            <begin position="669"/>
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        </location>
    </feature>
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        <location>
            <begin position="705"/>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="881" mass="96873" checksum="54FA690CC0038753" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4W4</accession>
    <name>A0A194X4W4_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">LY89DRAFT_686482</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="191" mass="21539" checksum="2CD52E5ADE003B5D" modified="2016-10-05" version="1">MAEDAVADSKASDSKATGLPAELRYIQYSHELEKQYLPAIRALISKDLSEPYSIYVYRYFLYQWGDLCFLAIHPTTSLLIGIVISKLETHQSHSPPTLRGYIAMLATSSAYRNQGIATTLVRKAIDAMIERGADEVVLETEESNTPAVKLYERLGFIRSKKLHRYYLNGSSAYRLVLHLKRTMDMSGEVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X574</accession>
    <name>A0A194X574_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_109012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205062.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28814788"/>
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    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="123" mass="14435" checksum="F0BEC2E1DB86B3E9" modified="2016-10-05" version="1">MKIDPEGVFMLGTDGVLRSFDENHMVLDAVGLSPEQIKEMLDQHPWDQEIEDKYRGVDGTNVVDMKQLYEPDEDSRPKELTEEEMRQAEEEIRVHNEKLMQQMEQDEKDGVDVAEKYRSKSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X592</accession>
    <name>A0A194X592_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_783518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X592"/>
    <dbReference type="GeneID" id="28832417"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783518"/>
    <dbReference type="InParanoid" id="A0A194X592"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267853" description="FAD-binding FR-type domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="216"/>
            <end position="234"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="243"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="281"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
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    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="285"/>
            <end position="401"/>
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        <location>
            <begin position="442"/>
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            <begin position="502"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ15353.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="78487" checksum="0A7D0151ECE20A09" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5W6</accession>
    <name>A0A194X5W6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LY89DRAFT_113663</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069824.1">
        <property type="nucleotide sequence ID" value="XM_018205091.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28814817"/>
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    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:phagophore assembly site membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:vacuole-isolation membrane contact site"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Aurora kinase A"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg1-like"/>
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        <property type="entry name" value="ATG1-like_MIT2"/>
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        <property type="entry name" value="Atg1-like_tMIT"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="26"/>
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        </location>
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    <feature type="binding site" evidence="20">
        <location>
            <position position="55"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KUJ15469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="975" mass="106402" checksum="DA2B9E39AA7EC227" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6Z9</accession>
    <name>A0A194X6Z9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_735093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070306.1">
        <property type="nucleotide sequence ID" value="XM_018219974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6Z9"/>
    <dbReference type="STRING" id="149040.A0A194X6Z9"/>
    <dbReference type="GeneID" id="28829700"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735093"/>
    <dbReference type="InParanoid" id="A0A194X6Z9"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="697" mass="78321" checksum="D75C5232A54586F6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8B4</accession>
    <name>A0A194X8B4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070387.1">
        <property type="nucleotide sequence ID" value="XM_018222661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8B4"/>
    <dbReference type="STRING" id="149040.A0A194X8B4"/>
    <dbReference type="GeneID" id="28832387"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783262"/>
    <dbReference type="InParanoid" id="A0A194X8B4"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="749" mass="85648" checksum="ED37A73620479F28" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8G1</accession>
    <name>A0A194X8G1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070805.1">
        <property type="nucleotide sequence ID" value="XM_018219921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8G1"/>
    <dbReference type="STRING" id="149040.A0A194X8G1"/>
    <dbReference type="GeneID" id="28829647"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734547"/>
    <dbReference type="InParanoid" id="A0A194X8G1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033388">
        <property type="term" value="P:putrescine biosynthetic process from arginine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009803">
        <property type="entry name" value="PRK13287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF15">
        <property type="entry name" value="FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="403" mass="44398" checksum="68B95E3D1D2AE883" modified="2016-10-05" version="1">MGPRENSPYFKYKNGLDPQLIRLGSLTLGYANPRLEEPYNHADILEAESSKLMTIDDREQCFILISNKMSGSSLGGLNKGPNSIVIGLCQSQLFSVTTAPELQSALSHILSLITKARNGYPHMDMIVFPEYMLHGLSMCTEDSILCSLDGPEVSALKLRCAEAKIWGCFSIMERNTLLPSAPWNTGIVINSSGELVNYYRKMHPWVPVEPWYPGNQGIPVFKGPRGVPMAHIICHDGQFPEMAHEAAYKGAEILLRTAGYTSPIKNSWEITNRSNAFCNLMWTCSVALAGSDGTFNSMGEAMFCNPEGEIVRKGDGVADEIFACGIDIRDVGEKRQHWGVENNLYQFGHRGYTAVEGGAGDCPYSYMQDLVAGKYKQVEEEKVLVTDGTSCGFEKPTAAYTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8P5</accession>
    <name>A0A194X8P5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_586075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070512.1">
        <property type="nucleotide sequence ID" value="XM_018209353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8P5"/>
    <dbReference type="GeneID" id="28819079"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586075"/>
    <dbReference type="InParanoid" id="A0A194X8P5"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="250" mass="26670" checksum="9324A822B4AC80B9" modified="2016-10-05" version="1" fragment="single">VTGGLGGVGAPVVDSILESGGDVVCLDLPPNPDNLTRFQTIASKHGTQLFYYSLNVTDENQVSSVINEAVSKLRYPLRGVVTAAGISGDVDAVDYPVEKFRKIMDVNVLGTFLVVRAATRVMQKEKVAGSVVLIASISGSIANKGVNTAAYNASKSAVLQLARSLAMEWANSPNHPPIRVNSLSPGHIYTPLSAVSIADEQTKKTWTDMIMMGRISYPEEYRAPILFLLGDGSTFMTGADLRVDGGHCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA45</accession>
    <name>A0A194XA45_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_586564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070992.1">
        <property type="nucleotide sequence ID" value="XM_018209375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA45"/>
    <dbReference type="GeneID" id="28819101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586564"/>
    <dbReference type="InParanoid" id="A0A194XA45"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF30">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="883" mass="99542" checksum="2079604DF4967902" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA94</accession>
    <name>A0A194XA94_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_543090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071445.1">
        <property type="nucleotide sequence ID" value="XM_018208204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA94"/>
    <dbReference type="FunCoup" id="A0A194XA94">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XA94"/>
    <dbReference type="GeneID" id="28817930"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_543090"/>
    <dbReference type="InParanoid" id="A0A194XA94"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="321"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="377" mass="41058" checksum="D213107898B84EE6" modified="2016-10-05" version="1" fragment="single">MEDEDGVPSSQGIDFCTMGMFIIDEIHYLPPKPPVFDVLGGGGAYSALGARLFSPPPLSQTISWIVDRGSDFPPHLTTQINSWSTSCLIRDDPTRLTTRGWNGYDDLENRAFKYTTPKLRIDEHALTPSLLFSKSFHMVCSPTRCISLVTGILRHRKAINPSAPKPLFIWEPVPDLCLPTELLNCTNALPYVDICSPNANELAGFMGDDEIDPSTGLISTTFVERACEQLLGSMPLQSFALVIRCGAQGCYVAKNGGRSRRASIVKRKRPRNYARGGLTLDMDMESLFAGLLNEDGSFEREEVPIDPGIELWLPAFFSKGEEERVVDPTGGGNGFLGGLAVALARGRGVEEAAVWGSVAASFMIEQVGVPVLGVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAW2</accession>
    <name>A0A194XAW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_696788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071658.1">
        <property type="nucleotide sequence ID" value="XM_018216858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAW2"/>
    <dbReference type="STRING" id="149040.A0A194XAW2"/>
    <dbReference type="GeneID" id="28826584"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696788"/>
    <dbReference type="InParanoid" id="A0A194XAW2"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="348" mass="37670" checksum="9B09A77D98542F0F" modified="2016-10-05" version="1">MEFPSKPLTQLLGSNGPVHALTYSSSPSTYILTGSSDRSIRLYNPSHPSSSSSSNPLAPPKPTQLIQTYTAHGYEILSLTVSADNATFASCGGDRSVFLWDVTTAQTLRRFGGNQGHTARINDVTFAGENNSLLISGSFDASVRIWDVKAGNMKPVMVLDEARDSVSCVLASESEEGVIWAGSTDGRVRAYDLRMGRVRTDVLGAPVTSLQRTRDGKGVLVGTLDSCVRLMDRGSGGCLRSYKAEGWRNEEFRVRSCFGGNERWVVCGNEEVKGDDGEVVVWDTLMGDVVERITVEGSKVEGKKKIGRDGKEKEKRNVISCVAWKENGRGDQWCCAGTDGIVTVFGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAY5</accession>
    <name>A0A194XAY5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_644752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071688.1">
        <property type="nucleotide sequence ID" value="XM_018211843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAY5"/>
    <dbReference type="GeneID" id="28821569"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644752"/>
    <dbReference type="InParanoid" id="A0A194XAY5"/>
    <dbReference type="OrthoDB" id="2332199at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27418" checksum="D4DCBEAEBC4527DE" modified="2016-10-05" version="1">MGIPHSTARWVAPVSFLIDFAAQQYGMLSSPNMKDVHDANLSFWSPQPFFIAGFFFPQQLFQLAWLYRLWKLDPSKGEKERQETQQMVDFVPYYAVGNLCIATWMIFWNASALKTANIFVLINSFTQLYYIFFRLPPMNTRSTSSVLTHIVSKTFAGIGVLDFLHNGSVAYFDHQGPNMLVKVGTGLGFAALASVSDWIFGGCLVYDLVALSVGQSGIKGQEGWGRLLGMYAAGTAAVVGVRNWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB99</accession>
    <name>A0A194XB99_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_70251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071392.1">
        <property type="nucleotide sequence ID" value="XM_018217259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB99"/>
    <dbReference type="FunCoup" id="A0A194XB99">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="GeneID" id="28826985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_70251"/>
    <dbReference type="InParanoid" id="A0A194XB99"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="293" mass="32511" checksum="E265A12649D40DF3" modified="2016-10-05" version="1">MAPIPSLKLNDGNSIPLLGFGTGTAQSKRRQEKPGFNQDLVDILEIAIKQGIRHIDGAEGYANEEEIGVAIKESGIPREELFITTKVRDIRTLPGAIDVSLEKLQLEYVDLYLIHSPYGAKELSELQTAWLAMESIQKSGKAKSIGVSNHLQPHIEAILEVATIVPAVNQIEFHPYLQRGNNLVPWLKEHGIEVTSYNGLTPLRKGLGGPLDGPLKEIAKKYGVSENAVLIQWQIHQGIVPITTSSKPERLAEYLQGVELKLEPEEVEEITRVGLTHHFRASQLTRFEPDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBK5</accession>
    <name>A0A194XBK5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_56395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071896.1">
        <property type="nucleotide sequence ID" value="XM_018208506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBK5"/>
    <dbReference type="GeneID" id="28818232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_56395"/>
    <dbReference type="InParanoid" id="A0A194XBK5"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268041" evidence="6">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="619" mass="66227" checksum="B0157048274F3900" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBL2</accession>
    <name>A0A194XBL2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_56723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071906.1">
        <property type="nucleotide sequence ID" value="XM_018208551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBL2"/>
    <dbReference type="GeneID" id="28818277"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_56723"/>
    <dbReference type="InParanoid" id="A0A194XBL2"/>
    <dbReference type="OrthoDB" id="3531381at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="36846" checksum="5C2D7BA6050A5D8B" modified="2016-10-05" version="1">MSIAYVTLHMVAAKHNDPVGITRPPELRLHAACFIMARLALVAWFMAFIASCVVISKPEACLVESQACQTQVADVVASLVAFVAMGIVLTALEACKYPFQIPDFLHISRRFTYRVSAFAEDLLDRSVSRTSSLRGHSEKSKASSQKSSVDEKPLPKPPSDISDVSPTRPITPLLPMAKPARSASTTSKGWGEEWTHLVREMNDGNPEKSGAKNSLDSAISLTYDSSSGYVSSSERSSHTRMSSYASTYRRSAIIEGGAYVTASRRTGVEMNAYASGSRRAPVARRPRPRVVTPSSSISNISRRSPLSTMRLVDFHVTAVSANTFPDLPSSQRWLSDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEH0</accession>
    <name>A0A194XEH0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072507.1">
        <property type="nucleotide sequence ID" value="XM_018219738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEH0"/>
    <dbReference type="STRING" id="149040.A0A194XEH0"/>
    <dbReference type="GeneID" id="28829464"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732844"/>
    <dbReference type="InParanoid" id="A0A194XEH0"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268130" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="258" mass="28118" checksum="71C811D8E95AB9DB" modified="2016-10-05" version="1">MFFSFVAVSSLLSVVSAAVLWDGRFSSSSLATIGSWSWSNQQGPYQYYIHGSGAISKYLSTSASYKNPAAKDDVGLKLTIDSTAKWNSDMLRTELIPQTTAAINKGLVYYHFSIMHSSTNPPSANEEHQVCFFESHFTELKFGWINGNAASTPDPALRWEVGGQSKWNTNFTADVWHNVAYEIDFSGGKVSFYHSTGADPLTLTAGPVTASASSNGEDWHLGVLRLPRSGYTDNTPEDWYFSGVYIESGTLTTSVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEP7</accession>
    <name>A0A194XEP7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_582156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073003.1">
        <property type="nucleotide sequence ID" value="XM_018209147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28818873"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582156"/>
    <dbReference type="InParanoid" id="A0A194XEP7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="906"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="939"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1349" mass="148334" checksum="80B0E98FB62E4AE1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEX3</accession>
    <name>A0A194XEX3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_668479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072672.1">
        <property type="nucleotide sequence ID" value="XM_018213042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEX3"/>
    <dbReference type="GeneID" id="28822768"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668479"/>
    <dbReference type="InParanoid" id="A0A194XEX3"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="570" mass="61160" checksum="B002C1BC33E74B51" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEX9</accession>
    <name>A0A194XEX9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073078.1">
        <property type="nucleotide sequence ID" value="XM_018214734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEX9"/>
    <dbReference type="GeneID" id="28824460"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683617"/>
    <dbReference type="InParanoid" id="A0A194XEX9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="91" mass="10263" checksum="66131C360FA4D636" modified="2016-10-05" version="1">MAEQQFSSLPGTTHNFASCINKIIRNIDTVSNVPKPLAIFLLLGLLFLLICHIVITLYLVIFLTFRTRHELKKQIRGIQTSLGLRDAGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFK5</accession>
    <name>A0A194XFK5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_683776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073303.1">
        <property type="nucleotide sequence ID" value="XM_018214757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFK5"/>
    <dbReference type="GeneID" id="28824483"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683776"/>
    <dbReference type="InParanoid" id="A0A194XFK5"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="78"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33385" checksum="A0FB92D3604BB23A" modified="2016-10-05" version="1">MQFSNRTSAALLSAAKLFQLPTFSLNHTSASTTMSPAPVIAVCHGGGPMPVMNDPGHAALIKSMETKVPSLLGLGTDSAPRAIVLITAHWRERRPTISNGKSHKLYYDYGGFPPETYKLKYDAPGSPEVASEVYGLLEKAGLNPKMDGERGWDHGVFIPMLLINPKADIPIVQVSIMSSDSPEQHYAMGRALAPLRDSGIAIIGSGMPTFHNLRLMFSGAANDAGFQRRNKEWSDRLTATVTKEDAVERGKLLESWRDWMGAEEAHPRGGEEHFLPLVVSAGAGGQGKGEGYGDDLMGTKHYTYYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG99</accession>
    <name>A0A194XG99_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_780806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073157.1">
        <property type="nucleotide sequence ID" value="XM_018222419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG99"/>
    <dbReference type="GeneID" id="28832145"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780806"/>
    <dbReference type="InParanoid" id="A0A194XG99"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268251" evidence="2">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="26059" checksum="14C82DD1844083A7" modified="2016-10-05" version="1">MQFTQLLVLALTVAVQAAPIDGEVGLEARHHKGATGATGAAGAKDAGAGGLAALFGGAAKAGAAKRDEELEARHHKGATTAATGAAKGAGAGGLAALFGGDKAGAAARDLEELEARHHKGATAKGAKKAGVAARDLEELEARHHKGAKKAGAAARDVEELEDRAAARDVEELEDRDLEELEARHHKGATAKGAKKAGAVARDVEELEARHHKGAKKAGAAARDVEELEARHHKGATTAATGAAKGAGAGGLAALFGGAKAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGH9</accession>
    <name>A0A194XGH9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1793-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_731680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="716"/>
        </location>
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        <location>
            <begin position="119"/>
            <end position="347"/>
        </location>
    </feature>
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            <begin position="355"/>
            <end position="699"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    <sequence length="716" mass="77450" checksum="34F19FEF5D53D327" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <begin position="138"/>
            <end position="158"/>
        </location>
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            <begin position="164"/>
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        </location>
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            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="41872" checksum="6A340C869769F6B1" modified="2016-10-05" version="1">MDGLAGALGSVIGYLGAEVAEKELLERLLWPQRFYNDCNIKTLLNQFLLMGMGGPLHRAALATLDDLRDHGLYLGPRRGDMLGTAFYRDLRTFNFWRTHEDNYAQPKESRNILWIEVLDTPSPNGVVRVGEEHITARGFLFVIASEGLAVAVALISNIEFGSWWMFAYFCTPLLLKCASILWSVRREGLMSIEQLSERGDVDQPEIFELEDKHHGFMIIEGPAPVIQQFFGHYGHPRRDEKHRGRILADRWREVLSIVLVYTFVLYFPAGLLALLWMNRNQQYLWLSYQLYATLAMHTTRVLGWSGCGRTEKRLARLLEQKKEVWLQSAGGCTVAATLDVTEVLNMAEGNRKVKELIQLRSLQNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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            <begin position="24"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="348" mass="41036" checksum="94628B6B73CBE417" modified="2016-10-05" version="1" fragment="single">PEAKLFNILLHVYTALFTRLANPCSINRQRTGLFTTQPLFKTQPTLSTKQFAKMPLQILITPPDPIQETRDQPFHTHDVGGKMLPENITTLPDHIKEPRGQLPNTQDIAEEMLPENITTQPDLAKKPRKQFPYTYDVGERPCVEKERTLRKLRERFGKGNFEFKIRLGKYIIQVPKELLPEVIDDMFRNDPLPVSYPKVSKPRPNLPAMAPLLHQDLGPLVLINEHETERKMHERFGVDENGKENYKIQIRRDHWIIWVPEIFKLKEAEEIFADVATEMKKSIEIEEMEKQKRMKEYWGEKREKVVIWFYVPVDFGPDLSPFKVLFWVRTLRIFEDFVAYRIEASFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI51</accession>
    <name>A0A194XI51_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
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    <dbReference type="InParanoid" id="A0A194XI51"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5008268324" evidence="2">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="142" mass="14666" checksum="CCC88F45685EDF1A" modified="2016-10-05" version="1">MRFSQFAILAVASAVTVAAAPAPADYGNYGAYGAYGQYQNYPQSTTTTSTSSTASATPTGYGSYGSYSAYKEKREALPEAAPEPEPAAAGYGNYGSYGKYGSYGSYPQSSKSSATPSPTPTGYGSYASYGSYKREGEAEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIF5</accession>
    <name>A0A194XIF5_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIF5"/>
    <dbReference type="STRING" id="149040.A0A194XIF5"/>
    <dbReference type="GeneID" id="28826499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695594"/>
    <dbReference type="InParanoid" id="A0A194XIF5"/>
    <dbReference type="OrthoDB" id="526941at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="397" mass="43740" checksum="A21A4C940EA85011" modified="2016-10-05" version="1">MGVVQKPSGNMKGGVSGQLKTPFVITIVVLFIVWSLLSLDMPSLRSTVDTNTSLESSPQPTNGAGLETSISNPTESPTEGSAADVIIAPTEPAAEESKPVSERPLILYAYADSEEGTSLVNLKFFIEHGLHDAADFIFILNGETTAGSLIPQEDNIRVVQRPNDCYDLGAYAEVLTTNDLYKGYKRFIMMNASLRGPFMPYWSNACWSDMYLSKITDEVKLVGMTANCWPTFHIQSMIWATDLTGLETLLFPPQSALDYISTHPILLPPPKNKEAAAKTPSPETSRVHQAPGINACFHTWDSAVAAEISSTSLIRAEGYKVDAMMAAYHGMRSYEEGVSCAENRDVLFDGEYFGTNVHPFETGFLKSNRDVDPLGLERQSQWMRGRGYRSYDYCRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIH8</accession>
    <name>A0A194XIH8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_666765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074279.1">
        <property type="nucleotide sequence ID" value="XM_018212936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIH8"/>
    <dbReference type="GeneID" id="28822662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666765"/>
    <dbReference type="InParanoid" id="A0A194XIH8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="433" mass="48470" checksum="71F695E45D62C813" modified="2016-10-05" version="1">MSDPKPLDVIVVGAGLGGCACAMAMHYAGFNVTVLEKVHKFLRLGDSLGLGENALRLLQRWGLHDQLIDIGNKSELMQIRRWGDGKILAQQPLMDMAGYIGHRGDYHEAFLARVKELGIEIKMGCNVVSYDENEPSLTLSSGEVYKADVIIAADGIKSLARELVLGFEDKPKSSGYACFRAFFKGAYLKSDPLCREFVEKECVNIWIGNDVHLVQNTLRDGDEFNWIITHKDTEDIKESWFQPGDMNEVRKLVEDVDPRIGNAVRSTKECLDWKICYRDPIPSWVSKSHKIVLLGDSCHPHLPTSAQGASQATESGAVLALCLKLGGKDNIPLATRVYEKLRFSRVRQSQLNGEDLRDRWHNALKDLDVDGEIDPESVKMRVRLFMSNRWLYPFDAEADTLHRWQEVSAQVSEELANGKIIPLFTGAASKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJG6</accession>
    <name>A0A194XJG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_639643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074626.1">
        <property type="nucleotide sequence ID" value="XM_018211631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJG6"/>
    <dbReference type="STRING" id="149040.A0A194XJG6"/>
    <dbReference type="GeneID" id="28821357"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639643"/>
    <dbReference type="InParanoid" id="A0A194XJG6"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="6">
        <location>
            <begin position="599"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="830" mass="92442" checksum="BB3A3424B38FD11A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJZ3</accession>
    <name>A0A194XJZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_682890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074462.1">
        <property type="nucleotide sequence ID" value="XM_018214593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJZ3"/>
    <dbReference type="STRING" id="149040.A0A194XJZ3"/>
    <dbReference type="GeneID" id="28824319"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682890"/>
    <dbReference type="InParanoid" id="A0A194XJZ3"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="435" mass="47541" checksum="9E6A3E9AC7A45A5D" modified="2016-10-05" version="1">MVKVKADNQLRGELGRPVEYLKAHEAVCFHQGEDMNALTVSFKRTIRVPEDGKVHALPPNLGFFPLYNVSHYADTLPKGMTSKGGCFMPVHEREALWIRFESTRPFGLKVYLGSINAISGEPLKETFASTMRRQQRFSDHINIQDYAVIDPAAQGQLWLDGIANTDGTVMQFVAVSSGTGYSVEAQIAKHEAVCGIQIIVAPIKRGAVAVLKVHRLGQTPLFPSVQLNATVYELMNMISATIDVPVEQFYLLHDNVVLEKNYLLSHYGITAQNSTLHLVLHLQGGGLVGNPNLPSEGEMGIAAGGLIRQAILRDPHASEVWDCKNVTTFFVQLLNANLLELVTSIAPPPSPITAELYAAAGLPFFSLPDEPKTGIYGKFSGVKSIGQMDVAKGKKKGLDRELKFPVIKLDRSGKHLFRPVGRMEALLKGMGFAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKG5</accession>
    <name>A0A194XKG5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_682039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074637.1">
        <property type="nucleotide sequence ID" value="XM_018214426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKG5"/>
    <dbReference type="STRING" id="149040.A0A194XKG5"/>
    <dbReference type="GeneID" id="28824152"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682039"/>
    <dbReference type="InParanoid" id="A0A194XKG5"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="80"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="5">
        <location>
            <begin position="620"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="6">
        <location>
            <begin position="846"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1185" mass="132756" checksum="0B1766EE4425A1AA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKH0</accession>
    <name>A0A194XKH0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_439326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074642.1">
        <property type="nucleotide sequence ID" value="XM_018207528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKH0"/>
    <dbReference type="FunCoup" id="A0A194XKH0">
        <property type="interactions" value="950"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKH0"/>
    <dbReference type="GeneID" id="28817254"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_439326"/>
    <dbReference type="InParanoid" id="A0A194XKH0"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="101"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="715" mass="79438" checksum="752A44F4E6803BEE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKK2</accession>
    <name>A0A194XKK2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075026.1">
        <property type="nucleotide sequence ID" value="XM_018222287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKK2"/>
    <dbReference type="GeneID" id="28832013"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779402"/>
    <dbReference type="InParanoid" id="A0A194XKK2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="15088" checksum="03772400132C1365" modified="2016-10-05" version="1">MIPELFFLFLMLIGVLMSILVFGLITVMDAISGRIKDFLQQRNLVPTSVIAFWYPKSVIDLMKSLILLVWMSVLVGHQILCGCIPFPDIYFEDFLICVASSYLQPENIVKVFPPLVQVAWMGVRRVWGYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKR1</accession>
    <name>A0A194XKR1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_779513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <end position="318"/>
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            <end position="197"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="882" mass="99909" checksum="9782D06DCE5863EF" modified="2016-10-05" version="1"> </sequence>
</entry>
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        <name evidence="4" type="ORF">LY89DRAFT_682211</name>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
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            <dbReference type="ARBA" id="ARBA00009670"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ20487.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="710" mass="80571" checksum="54641FF868E58C16" modified="2016-10-05" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <dbReference type="Pfam" id="PF21762"/>
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        <source>
            <dbReference type="EMBL" id="KUJ20966.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN35</accession>
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        </submittedName>
    </protein>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
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    </feature>
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        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="681" mass="76071" checksum="4B8990DDE1334FE5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT6</accession>
    <name>A0A194XNT6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_778153</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076129.1">
        <property type="nucleotide sequence ID" value="XM_018222189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNT6"/>
    <dbReference type="GeneID" id="28831915"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778153"/>
    <dbReference type="InParanoid" id="A0A194XNT6"/>
    <dbReference type="OrthoDB" id="3561274at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34379" checksum="56E773E1FA7EBC1A" modified="2016-10-05" version="1">MSSFPSFYGHPYLESSPDGGDSKTYYIQQYSKEIQCNIDSEAVCATKKLGKTKDGPDRGIRIFSILASLASATAAAIIMGKYHPRPFETAESALRTEERRPSLWDFPRRHLEKLSQFRELDSMNPGGRETKMHRMGCTIAIETIKASNSKGSLAEASLMLVQSKLSPLVQRLQTNLSDPPPLLFLAACIVFSVAIGNLWESQKQNGYRAWIVGLGMMIGTIAALRTENILQEGKGILAMSAIVALAISSCVHSMMRIHMIRKRFKAMLAEHTVDGHIEGEKRLAAKAGMDEKQSDLATAPEKERTTTETVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPD9</accession>
    <name>A0A194XPD9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative high-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_392469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076408.1">
        <property type="nucleotide sequence ID" value="XM_018207198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPD9"/>
    <dbReference type="GeneID" id="28816924"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_392469"/>
    <dbReference type="InParanoid" id="A0A194XPD9"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ22053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="542" mass="60080" checksum="F5124F2DDFB67466" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPS6</accession>
    <name>A0A194XPS6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_704824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076521.1">
        <property type="nucleotide sequence ID" value="XM_018217407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPS6"/>
    <dbReference type="STRING" id="149040.A0A194XPS6"/>
    <dbReference type="GeneID" id="28827133"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704824"/>
    <dbReference type="InParanoid" id="A0A194XPS6"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="178"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="48109" checksum="E055A7632D094498" modified="2016-10-05" version="1">MALPQDVKTATRAHYHNDDPEYPRQCERWGYSFPWNSNHMTAEELHVLRNSHDIIGLAAYESLKSILDAERTPSNDKTLSITGQQSDDWYDVLRIHHHEDDALQGFWNGVHTVPDWVDWKQIERGQRLFAKYASANLTFLFFYGFLRGSGVSGVKEVFTRTTSFTIQKFLPQFMGNFAWLIKVTNSLEYIQPGGEGHIDTIRIRLIHASVLHRIMKLAKIRPGYFNVEKIGLPINYFNSLHVLSIVSGSVLWDGLPKLGITASKQEQEDYIALFRYLAYLNGVPSERFENCEMAKATMESFLLAEEQPTPALKILAEDFVRWIEFKPPLFLSRGFLMAGFHHFNGAEYCQALGFTSPSFHNRMSFKGLCLLLNLVSLAQLWIPSFDQYIVIVSKFLYHITRNEHAKHLMTDFPQHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQK2</accession>
    <name>A0A194XQK2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_574825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076905.1">
        <property type="nucleotide sequence ID" value="XM_018208764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQK2"/>
    <dbReference type="FunCoup" id="A0A194XQK2">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="GeneID" id="28818490"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574825"/>
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    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
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        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
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    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22550.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="551" mass="59791" checksum="69CFD9529A0125A0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR70</accession>
    <name>A0A194XR70_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_728898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219318.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28829044"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728898"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43944" checksum="16B8AD5B13947A79" modified="2016-10-05" version="1">MATQNDFSYGDDIVTIVVKNASDKSKDEHIPVHKRHACRYSPVLEKAFGIDQKKEYKFLDTTASAVSALVSWFYMQEVNLDVHEGKYACLDQRPFSRQLLPDEQYQKAKACKDEVGTLIDLWILGGELQIFKLQNNTMIKLLAVAKTCALSFGPFYTRVYAKTQIGSPLREFIVRLCAWSEDFHEFESRPHLFPQEMLFDLLRTYSEALPPNVASARRHEMQRQYMDFTVTEHARDPDEGREISLSEMLQKYPRPELCPEAVGWGASDPPEAQHNVVKTSEKVENNELQDGGGLPSRRPWESDAGSGISDFMNPNYNTQNETETTPAPITENVEEDLLGLGRLGAWGNVTVVSSTPVGVPSEDLLGLLGSDHGGEEVNIACDCMLVCICGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR75</accession>
    <name>A0A194XR75_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_714514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077145.1">
        <property type="nucleotide sequence ID" value="XM_018218137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR75"/>
    <dbReference type="FunCoup" id="A0A194XR75">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XR75"/>
    <dbReference type="GeneID" id="28827863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714514"/>
    <dbReference type="InParanoid" id="A0A194XR75"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="461" mass="50587" checksum="A89F39AAECB8ED60" modified="2016-10-05" version="1">MCGKHDLESGGIDYADKRIFKRLMSREMPTLSAVAKTGKAHQFQIQGAEYLVLQQPLLFAILQQHSLLSLFTMLSRSSARSVSLTWASYQSLVKSAQAPLRSAQTSRSFATVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTVFKADNVPIEWEQVDVTGVESGDKHSEELFRESIASLKRNKLGLKGILHTPIERSGHQSFNVAMRQELDIYASIVLIKNIPGYKTRHDNVDLCIIRENTEGEYSGLEHQSVPGVVESLKIITRAKSERIAKFAFSFALANNRKKVTCIHKANIMKLADGLFRNTFNAVAKEYPTLETNDMIVDNASMQCVSRPQQFDVMVMPNLYGGILSNVGAALVGGPGIVPGCNMGREVAVFEPGCRHVGLDIKGKDQANPTAMILSGSMLLRHLGLDEHANRISKAVYDVIADGKTRTPDMGGNNSTHQFTRAVLDKMEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRR5</accession>
    <name>A0A194XRR5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_728952</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077196.1">
        <property type="nucleotide sequence ID" value="XM_018219327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRR5"/>
    <dbReference type="FunCoup" id="A0A194XRR5">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRR5"/>
    <dbReference type="GeneID" id="28829053"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728952"/>
    <dbReference type="InParanoid" id="A0A194XRR5"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="103"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="364" mass="40449" checksum="EDC6199926682126" modified="2016-10-05" version="1">MASATRTFARASSAFRTGTRNTLLTVSRQTFRCQRRGYASEPTKSSSSGLLIGVGALALGGAGYYFYTQGNGSLLSGSSGETKGIFTPRFEDYQKVYNEVAERLEEKDDYDDGSYGPVLVRLAWHASGTFDKETGTGGSNGATMRFAPEGDHGANAGLKAARDFLEPVKQKFPWISYSDLWILSGVCAIQEMQGPTIPYRPGRLDKDIAACTPDGRLPDASQGNKHLRDIFYRMGFNDQEIVALSGAHALGRCHTDRSGFEGPWTFSPTVVTNDYYDLLLKEKWSWKKWNGPKQYEDKTSKSLMMLPTDMALITDKSFRPWVEKYAKDNDLFFKDFSAVITKLFELGVPFAESTEKMTFKPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRT7</accession>
    <name>A0A194XRT7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_607800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077263.1">
        <property type="nucleotide sequence ID" value="XM_018210477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRT7"/>
    <dbReference type="STRING" id="149040.A0A194XRT7"/>
    <dbReference type="GeneID" id="28820203"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_607800"/>
    <dbReference type="InParanoid" id="A0A194XRT7"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052839">
        <property type="entry name" value="Mito_gene_expr_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46920:SF1">
        <property type="entry name" value="PROTEIN MSS51 HOMOLOG, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="50458" checksum="4264C4D247BB8F9C" modified="2016-10-05" version="1">MSKSERVLFPTPVSAVKGAICFTCYKATTKLNRCSGCRRVCYCSAECQKKDWRRGHKQLCPVLQGINALDSPKQSQTWEEYRDGMWTRVSAFRTQKAKFTVNDERVLQYQPYCIGCHLNAFQLPTGSTLKLCPKCQIAAHCSSCDLSLHDSVCSDLREVMTAERFAVAHYTETGEPSLSMPTGTPRTTYLPISTASSWYDYYTKISDKQMVEGLLSHDLKPLAGNDEMASALRAATEKMSMMISIIAGLEAVYPDLGTKEKVDLHLIGANAKELDALMLFEELLHLLPCLKEVNCSFVGLELPNPMDAGGRIVLDCCPECTKQKKVRSIEMHKGAYHDFAKSPAYKKPDLAVAFQTGHSQECVDDWTPTIRYLVHAPHCTMFTTFNEKEMVEEIEILKKLDAKFLVDGEKNKWQGMRPLLEVIEETENSVYYNHQYWYVVQGLLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS48</accession>
    <name>A0A194XS48_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_303516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076907.1">
        <property type="nucleotide sequence ID" value="XM_018206590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS48"/>
    <dbReference type="GeneID" id="28816316"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_303516"/>
    <dbReference type="InParanoid" id="A0A194XS48"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="144" mass="16566" checksum="02F85E32A53759AF" modified="2016-10-05" version="1">MWKSQLPATYFLEVTYLKVKGFCPSNEFEYTFPSTDYPYLQILPRLSWLLTLNMSFQLMNRSTMGGISLFLYFCSCSMALFGLGDSLFEEPGLIIHESRLICSRGITVPNVCMIFSILLFLIFIFTSAWEAWGKGKGERDHPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSJ7</accession>
    <name>A0A194XSJ7_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">WD repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_703753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSJ7"/>
    <dbReference type="FunCoup" id="A0A194XSJ7">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSJ7"/>
    <dbReference type="GeneID" id="28827069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703753"/>
    <dbReference type="InParanoid" id="A0A194XSJ7"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="635"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="994" mass="108445" checksum="6FAE66C9A12AECC9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSM8</accession>
    <name>A0A194XSM8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077399.1">
        <property type="nucleotide sequence ID" value="XM_018213955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSM8"/>
    <dbReference type="GeneID" id="28823681"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679862"/>
    <dbReference type="InParanoid" id="A0A194XSM8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268564" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10753" checksum="CD650BF8EA7D2003" modified="2016-10-05" version="1">MRLQRCCCLLVLRLGLLVGKPSGVPGFENVEAGGRLVLVQPVADWRFILSRGQWISGKHYCSNPIEIRLGEERRGERGFSHCNAEPKREQMFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT12</accession>
    <name>A0A194XT12_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_170220</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077539.1">
        <property type="nucleotide sequence ID" value="XM_018205564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT12"/>
    <dbReference type="STRING" id="149040.A0A194XT12"/>
    <dbReference type="GeneID" id="28815290"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_170220"/>
    <dbReference type="InParanoid" id="A0A194XT12"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="184"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="400" mass="44511" checksum="A86C42BC028D980A" modified="2016-10-05" version="1">MAAFVRVSGPPNSNFLVGYPGISATLPRIEGKVEIRPLTGISAPVAISLVRICLQRRETIHPSAESIAKKHLGTPRRETTDVVGKELLLFRCPAGRESESVVLMDLPFVLFIPFGRGGEESNRRIPPASLQLPSRTAETFYELVVTVQQGQEQKKFAFPVPIQRYDTLSTFGMYNRPEAAEKTSDHLVTLGISLPRWSYGPLDPVSVYIKLSPNPDWMNKAKKVMIQKITIGIEEEITYNPEGDEPTKKINRIAKHTQTVGVKMPEAGYFTNLGLVFPSKELRDPEGIIRRGKPAFPMYSVNSFTTTGTLYKIEFFLIIKAHMSAARDIVLRQPIVVCPLDQQDCKEEMDAIEQAAKDASHVDPHNPMLPACTIIRANDKDALKALGWTMVGGQKKMVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT50</accession>
    <name>A0A194XT50_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_663914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077840.1">
        <property type="nucleotide sequence ID" value="XM_018212735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT50"/>
    <dbReference type="GeneID" id="28822461"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663914"/>
    <dbReference type="InParanoid" id="A0A194XT50"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="630" mass="71006" checksum="5E4932B59B01F224" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTL6</accession>
    <name>A0A194XTL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase pc-bph</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_606417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077908.1">
        <property type="nucleotide sequence ID" value="XM_018210422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTL6"/>
    <dbReference type="STRING" id="149040.A0A194XTL6"/>
    <dbReference type="GeneID" id="28820148"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606417"/>
    <dbReference type="InParanoid" id="A0A194XTL6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="527" mass="59369" checksum="03365C09888D2EFB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVC0</accession>
    <name>A0A194XVC0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078518.1">
        <property type="nucleotide sequence ID" value="XM_018213857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVC0"/>
    <dbReference type="GeneID" id="28823583"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679377"/>
    <dbReference type="InParanoid" id="A0A194XVC0"/>
    <dbReference type="OrthoDB" id="3518533at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268648" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="24493" checksum="0FA0DC834757E8FE" modified="2016-10-05" version="1">MHSTITFPALALALSSNVFAAPLLQVRQNTLTTADTVQFVAKTIGSNPNATTFPDINNWLFQPVHSGAGTNLATLVDPSTASFNLSAPGYFQNGTDAPHSTGGYMVAGFIDSTAPYSLVLDVAHEANSSNPGAELGYVEMNIGLGTDGLNVPDGQLITSEYVTDTFYACPNVPVEGGSVIAIEVIDRYATPPEGCWSIELYAQCAGPITDSDRVAFPAFVQSSCYANATSAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVT5</accession>
    <name>A0A194XVT5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_604553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078479.1">
        <property type="nucleotide sequence ID" value="XM_018210364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVT5"/>
    <dbReference type="FunCoup" id="A0A194XVT5">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XVT5"/>
    <dbReference type="GeneID" id="28820090"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604553"/>
    <dbReference type="InParanoid" id="A0A194XVT5"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="10">
        <location>
            <begin position="547"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ24124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="631" mass="68037" checksum="CC441E4145E6BE6F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW00</accession>
    <name>A0A194XW00_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_679471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078666.1">
        <property type="nucleotide sequence ID" value="XM_018213880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW00"/>
    <dbReference type="FunCoup" id="A0A194XW00">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XW00"/>
    <dbReference type="GeneID" id="28823606"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679471"/>
    <dbReference type="InParanoid" id="A0A194XW00"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="23350" checksum="71D0C678212CF5D3" modified="2016-10-05" version="1">MPLFTKPRQSLHSSIAKSFTYKSPTRYFHASSANMTIKTFFDVTWEGPVLDAAGKPTSKVAEQAGRINFLLYDDIVPKTAENFRALCTGEKGYGYASSSFHRIIPQFMLQGGDFTRGNGTGGKSIYGEKFADENFQKKHTKPGLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGEVADQESLAVVKALEATGSGSGKVTYNKKPTIVKSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B367</accession>
    <name>A0A132B367_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_768765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061203.1">
        <property type="nucleotide sequence ID" value="XM_018221799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B367"/>
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    </dbReference>
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        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="9931" checksum="351E9CB15C57CC36" modified="2016-05-11" version="1">MSAPNASQPSMVTGHAQYAKGYVEETIGNVTGSKEWQESGKKDTAEGISEMKAANQARSGEPAASGIGGKIEEVAGKVAGCEGMEKEGLERQEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3B6</accession>
    <name>A0A132B3B6_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_743531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
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    <dbReference type="GeneID" id="28830686"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743531"/>
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    <dbReference type="OrthoDB" id="10248398at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="4">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="26124" checksum="5992ABBC92FFFE9A" modified="2016-05-11" version="1">MAQQQQQLPQLFGIIPTSHPCLTLPTSAPTPTSYLYTLPLPSSRPFSHITVFLLPGITLPPATAAAVYISLPSSSTQSNQPSQPQFRFLGGIGPGKESAVFKISGLGAGGAGGGGNGGGAGGEVDMDSDIPSSSSSSSGEITLGISLESADSVSAQISALHSTTSTTSSTSNPSSSDSQAMILARVGGGNTNQETTVKLAQKIIKNAFNFLASFSGNTANGIEVVPLKAFEEWWRKFEGRVRSDAGFLERGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3H1</accession>
    <name>A0A132B3H1_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060944.1">
        <property type="nucleotide sequence ID" value="XM_018220972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3H1"/>
    <dbReference type="GeneID" id="28830698"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743732"/>
    <dbReference type="InParanoid" id="A0A132B3H1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="202" mass="22697" checksum="33824984E36D9836" modified="2016-05-11" version="1">MITRKPHLQNLRSLIQQAMKQRTPTSLPRISLPQRRYPSDLPSASTDSTAAPSLAPISIVLNLINSQPTNSTQTSNTAEPPNTAMCRYSDVGGVFTGWRVYTTGNWTGDHGKELHSKLKKRCGGIVQWQFRYENKTLNQWNNDFWGSGDGLADFKTWKFHTKWCVERAVRDATKNAPGGLSGGEKAIECKHLVYIDTEDTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3M7</accession>
    <name>A0A132B3M7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_790099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061363.1">
        <property type="nucleotide sequence ID" value="XM_018223333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3M7"/>
    <dbReference type="STRING" id="149040.A0A132B3M7"/>
    <dbReference type="GeneID" id="28833059"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790099"/>
    <dbReference type="InParanoid" id="A0A132B3M7"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="285"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="816" mass="94684" checksum="CB81E1E6A7B28F84" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3W5</accession>
    <name>A0A132B3W5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_632023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061376.1">
        <property type="nucleotide sequence ID" value="XM_018211292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3W5"/>
    <dbReference type="GeneID" id="28821018"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632023"/>
    <dbReference type="InParanoid" id="A0A132B3W5"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
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            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
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            <begin position="252"/>
            <end position="338"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="425" mass="47758" checksum="6B449B23CAA45C4B" modified="2016-05-11" version="1">MSELLTLAKGLNPWPFFALQLSTSILTLGFTSPSSLFRPTILPFVASCTYITCLNLREFTSRGSWAATTACFSTLFFLQYLEMGVLSRWSFEARGPTSTSSKNSQDREAKKEDTIWTRLKFGTSSMISFRDLYTPHETKNSPHFSPKNPSYTPSRSTFLLTSIPKLVLCYLILDLIEFQPPPPDASSLFSPSKVPFLLRIFSGEEAVTGEDVLVRIASSIGFWISLYCMISGMALFLGVVCVGLGVSEVKEWRPIMGSLSSAYTIRGFWGEFWHQGTRKTFSYPSNYLIDHLPVKLPRLLARYAKIFLTFYVSGVVHVIGDWTGFMPWAESGSVRFFMAQAGGILVEDAVQWVWRTLVGKEKGKGNEKEEKKGGKVWMKIVGFVWVSIFMLFWSTPAWIYPTARLNAGGVEGKVLPFSVIGFFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B463</accession>
    <name>A0A132B463_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216513.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_692319"/>
    <dbReference type="InParanoid" id="A0A132B463"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12096" checksum="D3A185AC1DB3A679" modified="2016-05-11" version="1" fragment="single">MQPRNRHSHQQYNTYKYLLSPPPLPSSCSLSFLSSFTLPDLITLTKQREKTKTMASQDEILLAAILKQVTVTKINYEQLAKDIGAVSAGAASKRWRRYQGRLKGAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B466</accession>
    <name>A0A132B466_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_768690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1 8">Belongs to the tannase family.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221798.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_768690"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="574" mass="63008" checksum="A7B5EB158DC58C57" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4D1</accession>
    <name>A0A132B4D1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061224.1">
        <property type="nucleotide sequence ID" value="XM_018216491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4D1"/>
    <dbReference type="STRING" id="149040.A0A132B4D1"/>
    <dbReference type="GeneID" id="28826217"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692225"/>
    <dbReference type="InParanoid" id="A0A132B4D1"/>
    <dbReference type="OrthoDB" id="3564803at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="723" mass="79756" checksum="53DDF1212952114F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4M1</accession>
    <name>A0A132B4M1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_691813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061710.1">
        <property type="nucleotide sequence ID" value="XM_018216413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4M1"/>
    <dbReference type="GeneID" id="28826139"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691813"/>
    <dbReference type="InParanoid" id="A0A132B4M1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="29189" checksum="FEA5DD9B3D2DB35B" modified="2016-05-11" version="1">MPKSINSDLVDGGSARNDGLSTQNFDDCDSGEGYHSSSISARNEYTQNSNNYDSKEGYHSSSINSDLDRGSRGHHRSSSINSNFDRDSGESHHPSSINSNLDRKDSKGYYRSSFIKSDLDCDSRGHHRSSSINSNNNNNSILLEYPPPIYSMSPIPLLPLFQIPAATPAAAAVASPPAVVAAADPPAAVVADLSEVVVANPPANQPTTLQPAASQRNARQQDAHQAGVTIHGSRGCCSPSINMDSTSCSIICGCIAGGLITAGYVLAVYFKGLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B613</accession>
    <name>A0A132B613_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_353274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062195.1">
        <property type="nucleotide sequence ID" value="XM_018206946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B613"/>
    <dbReference type="STRING" id="149040.A0A132B613"/>
    <dbReference type="GeneID" id="28816672"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_353274"/>
    <dbReference type="InParanoid" id="A0A132B613"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="728"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="793"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ07840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1213" mass="134598" checksum="F2E5CD09C1805DC8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6J6</accession>
    <name>A0A132B6J6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_348215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062380.1">
        <property type="nucleotide sequence ID" value="XM_018206901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6J6"/>
    <dbReference type="GeneID" id="28816627"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_348215"/>
    <dbReference type="InParanoid" id="A0A132B6J6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="134" mass="14913" checksum="EEBBFC1DBD2E7AF6" modified="2016-05-11" version="1">MASTPLGSWKWKWNGSAQSLDDVSSRPTAAVSLVSVCTLARRRGADKHLVVRRLSDGVCYASRSSIHICNKERNEGNTWLWLRAATYVMNHSCPSDRQLPVLHQLYVHQKKDQYMSPSTSLAGASRIVCLIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6N4</accession>
    <name>A0A132B6N4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_357007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061899.1">
        <property type="nucleotide sequence ID" value="XM_018206971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6N4"/>
    <dbReference type="GeneID" id="28816697"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_357007"/>
    <dbReference type="InParanoid" id="A0A132B6N4"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="54152" checksum="C88DDE1876EF0647" modified="2016-05-11" version="1">MNKPTAKPPRRQSCDRCHAQKLRCSRQGTGSGDRCTRCSRQNAECVYSTSLPKGRPSAHRLQLAGASAGAGNGNVKSSRSEGESRIKEGANGTENENGTASVSIATSTETTAIVDIGGHEIQAELDCITSSNTHGNDSDNITISLVQSPENLTPPSITERNRHYPPIPPPITTTWEREHGLLTAPFSSPGTNISFGDGDAGPWDSEPYYWSDWVGSDLSVSGRPLSALTPPSTSHGTSLAGHPCTDTVSPAAAAPTPNIFNPNSTSSNYDSHGHSAHSGHGRGDYGSIPTTQGCITQLSELLTRLSSAFAAAQQELIPGSPSLVINTAFDSLAALLVSPTVVLPGADQASDAVRDTFSASQRLLEILHHLQDLQLGEEGGKMDVDSPCLPAPPPTPPPRSPPSGEQFSQRTRSQHSDTVVHHLVLACHSLLLNIYGPLLAALQHDALASDSDGVLAPSLVDMRLILLVQLCSYFIDRLHEGVSGLCLQTTVDLEAEIQQKLLRLRRTLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Z5</accession>
    <name>A0A132B6Z5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_600056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062537.1">
        <property type="nucleotide sequence ID" value="XM_018210135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Z5"/>
    <dbReference type="GeneID" id="28819861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600056"/>
    <dbReference type="InParanoid" id="A0A132B6Z5"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF34">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287929" evidence="5">
        <location>
            <begin position="18"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="56964" checksum="B6A595A13C70F816" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B741</accession>
    <name>A0A132B741_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_659779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062418.1">
        <property type="nucleotide sequence ID" value="XM_018212526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B741"/>
    <dbReference type="GeneID" id="28822252"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659779"/>
    <dbReference type="InParanoid" id="A0A132B741"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="413" mass="47142" checksum="ABA5F48F398C1A72" modified="2016-05-11" version="1">MGSSKLSQPPAAYRDDPDYAETASMSSAVLLDDVESAFPEEELPAYTDEPSAPLVDPSCSSESAAPPPASEQAILHGYYCPPCELPFSTHDLSYTEYRTRFPNYSTDSNQLYKMIRHQAAHCPSYFVTIYGTHTETRRNGNKETKDKITDFHLRINISYLLGQIGSGKMELLADNKRGYRGTRLASLKPSVSADEENAPDELRRWCDRYVADPSGVKSFLLKRKILNHDTKKLEQLIRSAISETNYRGHVSIDFPIQHQKVLVYSPGRLNEWRITVWIRWFFYLTFLWIFAWPVLFFMTARYEVVKVNYLYATEESGHPARTCSVMSEVEWYYRWQSAIKRAALARMVCKDTCLDEEYRAQTQLADERGERVGREPDIPRTGNTWADGALGLLGQGLRVAENYSNARGWGADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7X5</accession>
    <name>A0A132B7X5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carnitine acetyl transferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_629641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062857.1">
        <property type="nucleotide sequence ID" value="XM_018211213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7X5"/>
    <dbReference type="FunCoup" id="A0A132B7X5">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B7X5"/>
    <dbReference type="GeneID" id="28820939"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_629641"/>
    <dbReference type="InParanoid" id="A0A132B7X5"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="87"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="865" mass="95058" checksum="EE3A36F8F683F0D5" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBP7</accession>
    <name>A0A132BBP7_MOLSC</name>
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        <submittedName>
            <fullName evidence="9">Linoleate diol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_597857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28819727"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597857"/>
    <dbReference type="InParanoid" id="A0A132BBP7"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
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    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="33"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ09693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1064" mass="117661" checksum="E36B58B0745504CD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC35</accession>
    <name>A0A132BC35_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_724016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC35"/>
    <dbReference type="GeneID" id="28828587"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724016"/>
    <dbReference type="InParanoid" id="A0A132BC35"/>
    <dbReference type="OrthoDB" id="4820608at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288107" evidence="1">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="30083" checksum="6465AF5DC8929B58" modified="2016-05-11" version="1">MQSNNSFRLAAATTLLAACGLVSAQIPVVTMFPVTTQTSFPSPQCTGTSSTESFTVNYNFESVERGDPIIATTEIAEYNLLNFKSINFVDTDTDFDGNHLGLAPHTYPYVATFSPGTEIIDDLLSPNISMITASYIESTLTSFTPKSFWYGCVYPFPYTAGSLPVDCNITATGFDKSGNLVAKQSFEFSGNGSIIQDQNYGTFQGFSQVYSVAFGVSPIIAAALVDNIIATLYQEECAPYYTGSYGNGTSSSWIYTSGLSGHARYPSLLHSITTFQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCD8</accession>
    <name>A0A132BCD8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_275416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064024.1">
        <property type="nucleotide sequence ID" value="XM_018206401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCD8"/>
    <dbReference type="STRING" id="149040.A0A132BCD8"/>
    <dbReference type="GeneID" id="28816127"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_275416"/>
    <dbReference type="InParanoid" id="A0A132BCD8"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="30111" checksum="C3FBC6FF0FA3621D" modified="2016-05-11" version="1">MDALRNALQPITHNLPAPIRDLGVSIIGETCYKTLLLDIDLESTECIKLAVSKGLGIGIIAASSIVKVPQILKLLNSQSASGISFLSYLLETSAYLISLAYNVRQGFPFSTYGETGLIMAQNVVIAVLVLHYSGKQAAAATFVAGLAASAFTLFSDNIVDMKTLGYLQAGAGALGVASKLPQIAAIWQEGGTGQLSAFAVFNYLVGSLSRIFTTLQEVDDKLILYGFIAGFALNAVLAAQMVYYWNGPAAKPVKEKKAEKVPIASGSSGVSTATPKGKSPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCL0</accession>
    <name>A0A132BCL0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_675597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064466.1">
        <property type="nucleotide sequence ID" value="XM_018213523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCL0"/>
    <dbReference type="STRING" id="149040.A0A132BCL0"/>
    <dbReference type="GeneID" id="28823249"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675597"/>
    <dbReference type="InParanoid" id="A0A132BCL0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="36570" checksum="85FD5AA4672A47BF" modified="2016-05-11" version="1">MPYFQPNLTLPSSLSFHNKTILITGASAGLGLAATKALLHHGAKEVIAAVRNISKAKEATSKFLSDPELKKTNPQAKITILHLDLEDYASVLSLAQEVKKRYDGKLDMLLLNAGTGSLKWERAAKSGHEKTIQVNLLSPALLAVELLPALDKTATITGVPSRITWVGSFVQFDHTLEKKPIEDVGNVLGHFDDESKFVSMGRYSDSKLLGTIFVEQLAGYVDPGKVVVNDVSPGMVRTGFGEYPLWLRGMFTVFFGLKARSVEEGAKTYLYALAVAGKESHGKYLSDNLITERAQIISTSVGKELRKGLWNDMWKDFLRQDGKLEPLKPRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCN8</accession>
    <name>A0A132BCN8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_710907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064511.1">
        <property type="nucleotide sequence ID" value="XM_018217869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCN8"/>
    <dbReference type="GeneID" id="28827595"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710907"/>
    <dbReference type="InParanoid" id="A0A132BCN8"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="578" mass="62923" checksum="BFE64358495EA72B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCY8</accession>
    <name>A0A132BCY8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_537403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064603.1">
        <property type="nucleotide sequence ID" value="XM_018208116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCY8"/>
    <dbReference type="GeneID" id="28817842"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_537403"/>
    <dbReference type="InParanoid" id="A0A132BCY8"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="267" mass="29512" checksum="63C04AEDD97023E4" modified="2016-05-11" version="1" fragment="single">SSIARNRQSSHPGRRRSTVLMSLQLNDPTMPPPGEMVHEGTPVYRTASPQSMQASPITSSGEPQLPQHFRAPSLGEIHQELEQEQEAQVNRLLQMIRAQQQQLQQLQAASGQSNATPPVIDEFTPTSERSMSFSTAGVQQQSTVSTPRSPSAALHPRSSFDLARADLQQRRSRTPSRTASPRLRSTSISGEGEPFSLAGRDESAFYQAETQMMIRENQMLRQRIRELERQVSELHVNSAITHEPATPSQLLRSESISELSAPSISPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD78</accession>
    <name>A0A132BD78_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_689630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064711.1">
        <property type="nucleotide sequence ID" value="XM_018215943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD78"/>
    <dbReference type="GeneID" id="28825669"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689630"/>
    <dbReference type="InParanoid" id="A0A132BD78"/>
    <dbReference type="OrthoDB" id="5346740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029178">
        <property type="entry name" value="Ecm11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF3">
        <property type="entry name" value="EXTRACELLULAR MUTANT PROTEIN 11 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15463">
        <property type="entry name" value="ECM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extracellular mutant protein 11 C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="48423" checksum="5BFE9135C24409D5" modified="2016-05-11" version="1">MASRFTQLQEQARNGTNSPVPRSGVIPGREDAHQLKFKHGSVSSTSKKLPGITPVPVYTSNPPAYRTTYPPAQYVPEQVSSFGGGLDDSTVASDFDETITSDLAVPHHFAEDDETQPFEDEEPYASQQAEYQSYSQSQHPRLSVQHRLQHKQSQSPMIEQNAEQELLRISGQFGGQKHGNLVVRSLEDPTPSRAKRQSRKRSRSGDHNAQPSIIVEERSSQMDDVEEIMPQLPESEVLSENDESEEEDAPTPNPSPSKNRRKKEPLISQQTPRPVKPTEAPKKDPIVPDYTDAQLRKMTYAELENESWEKIDDKKTFQLAKPLRDTSALEEKMEHYAFKEGQDAQVAFYGQLSHSDWENGGDWFVERFTDLMNELKKKRIEKKAITQKYEAELSAREKSVRGKSDNLDREFKDMRVGGEGILKGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-09-13" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDR9</accession>
    <name>A0A132BDR9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064920.1">
        <property type="nucleotide sequence ID" value="XM_018220569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDR9"/>
    <dbReference type="GeneID" id="28830295"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740273"/>
    <dbReference type="InParanoid" id="A0A132BDR9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288165" description="WAP domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14916" checksum="F9ED951F3109B46C" modified="2016-05-11" version="1">MYIFSRALLIASLLGFVLSIVLHPIHDSPRKSIHHKDFPSITNIDPPAAGSCLANGLLCVKDSGCCSKNCSGRVCKPKLEGRLGLKKKQAPYKIRPKATKQEKSAGVRTAQMEQWVTKQKPLGKDGLQSHQPKEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSS9</accession>
    <name>A0A194WSS9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_655435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065032.1">
        <property type="nucleotide sequence ID" value="XM_018212344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSS9"/>
    <dbReference type="FunCoup" id="A0A194WSS9">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WSS9"/>
    <dbReference type="GeneID" id="28822070"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655435"/>
    <dbReference type="InParanoid" id="A0A194WSS9"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="453"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="632"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="688"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="787" mass="87638" checksum="DCCB3994A48E8048" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT07</accession>
    <name>A0A194WT07_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_710270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065450.1">
        <property type="nucleotide sequence ID" value="XM_018217816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT07"/>
    <dbReference type="GeneID" id="28827542"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710270"/>
    <dbReference type="InParanoid" id="A0A194WT07"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="101"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="55124" checksum="BA672EBB04860787" modified="2016-10-05" version="1">MLLLEVPIAGGKLSPVSLPAIFPLRYAPISESHVDFSGGEQGVFSPHVAGMGQGQPMSVYGSLYACIHYLGLRLEYGQSSVAGRGTCGRAFWVVWKIDLHLITALFGVFIFNILDRSNIASARLGGLQTDLKLTDTQYQTAVSIMFVGYLLGQIPSNMVLTKLNPSRYLPVAIFIWGGLSLATAGVHNFSQIFAVRFLIGFAESPFFAGALLLISSWYKPSEIAPRVALMYCGNTVANGFGGVLAAGVLSGFDGASGLEGWRWLYIIEGAGTMLTEQEQRLAEWRIAASANGELDETSSLKQGLIDTVTDIKVWLLVLTQICLLSSQTWTYFFPSIVQTLGYGRIRSLLLTSPVYVFGFFTSLGNSLVAAKTGHRAILVIWPLCLAIVDNSHQTAVRYIGMFLMCAGSFSAFNVLEAWVGSTVPRTRTKRAITYALVNMLGNLSNIYGSYFFPAASAPQYVLGGVVLSSFAAGGVCFAAVLGLYLRRENKRAVEAENEDGVMRYKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTR0</accession>
    <name>A0A194WTR0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_786661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065352.1">
        <property type="nucleotide sequence ID" value="XM_018223007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTR0"/>
    <dbReference type="GeneID" id="28832733"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786661"/>
    <dbReference type="InParanoid" id="A0A194WTR0"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="713" mass="78263" checksum="55D7B91CE242AE93" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTU7</accession>
    <name>A0A194WTU7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoaspartyl dipeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_786693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065392.1">
        <property type="nucleotide sequence ID" value="XM_018223010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTU7"/>
    <dbReference type="STRING" id="149040.A0A194WTU7"/>
    <dbReference type="GeneID" id="28832736"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786693"/>
    <dbReference type="InParanoid" id="A0A194WTU7"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="111"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="54662" checksum="3DCB4F6222B94276" modified="2016-10-05" version="1">MAPSRTDEPLPSFTQANNEPYHGPPRNIKNIDAIEFSASLQPKNYNILGTHPDSRILFLDVNILDSSGRDPYRGDVLIERERITRVGTVLNVEELKRDPKVRVFHGRGRTLMSGLGDAHTHFTWNGGDLNRLGELGVEEHTLLTARSAQCYLDSGYTMCFGAASAKDRLDIVIRDAINAGDIPGPRYLANGKEIARRDGDLVPGITAYADGPDEMREVIRHHVDIGVDQIKLSMSGEEITEIRSAQDCYFSDEETAACVDEAHGLGKRLCAHARARDSVKMCVRHGVDVIYHASYIDEEGMDMLEKQKDKHVVAPGINWLIATLHDAAAFGYPNEKAQQVGYQKEYDASIRGLREMHRRGITVLPGGDYGFAWTPHGTYARDLSHFVNLLGFTPMEAIIAATAGVAKLFMRENELGKIKEGFFADSILVDGDPLEDIGCLQDHDRLNVIVINGRVHKAGREEYVAPPIAGQDGGVHPIVPNFPEVKREMQKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV14</accession>
    <name>A0A194WV14_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_653228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066160.1">
        <property type="nucleotide sequence ID" value="XM_018212240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV14"/>
    <dbReference type="FunCoup" id="A0A194WV14">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="28821966"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653228"/>
    <dbReference type="InParanoid" id="A0A194WV14"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31878" checksum="62BBC600D6D040DD" modified="2016-10-05" version="1">MSTSAPKHLILVCCHAIYTGGPTRGLNEQEWLLAPFQLGETPTFIEHIRAALSLLTLDPESLLVLSGSKTRRETDKSEAKSYLDLCEDNDFWDILHKDGEERKRVILEEQALDSFGNLIFGLLVFWKRTKRWPLKVSIVSHEFKRRRFLDLHVRALRYPKESVVFVGIDPSYMRQGSRDYDEARTRSVVGGEMERGFREWEKDLSGVAMVLRAKRVGRNPWSASQVWFESDEERLESGVRSKVVEFEHMDAQRGAIKVTEEVLIEGRQPWEMGEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV57</accession>
    <name>A0A194WV57_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phytase A</fullName>
            <ecNumber evidence="4">3.1.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Histidine acid phosphatase phyA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Myo-inositol hexakisphosphate phosphohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Myo-inositol-hexaphosphate 3-phosphohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_758253</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84142"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="4"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065904.1">
        <property type="nucleotide sequence ID" value="XM_018221429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV57"/>
    <dbReference type="GeneID" id="28831155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758253"/>
    <dbReference type="InParanoid" id="A0A194WV57"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267559" description="Phytase A" evidence="20">
        <location>
            <begin position="17"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="56"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="426"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="457" mass="50994" checksum="73B6C1B96B0425DC" modified="2016-10-05" version="1">MLSIILLGTFISLGSAQCDTVETGYQCDTSISHNWGNYAPYFSVPSTISADTPAGCSISFVNLLSRHGARFPTTSKTTEYEELFEQIHANTTSYSAEYDFIKNYTYDLGANDLTAFGQQEMIHSGIKFYERYKTLTTLYTPFFRSSSDDRVVESAQNFSQGFHQARGSIDPNYPYPILLISEDDGQNNTLYAQLCTNYEDGPDSDIANDAEDTWRDVWISEVKTRVNDNLIDASLSKSQIIYLMDQCPFNTIANVNGTISSFCGLFNEMEWENYNYYRSLSKWYADLQGNPLGPTQGVGFAAELIARMTNNRNYVTDANSYTSINHTLDYFSTTFPLGPDLVHPLYADFSHDDDLGSIFAALGLYNSTANLSNITLETTTQTNGYSAGWTVPFAARAYFEKMVCLSEVEELVRVVINDRVVPLQNCDADSLGRCTLSKFVASQSFVTGGGLWGQCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVB9</accession>
    <name>A0A194WVB9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_543119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066266.1">
        <property type="nucleotide sequence ID" value="XM_018208205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVB9"/>
    <dbReference type="GeneID" id="28817931"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_543119"/>
    <dbReference type="InParanoid" id="A0A194WVB9"/>
    <dbReference type="OrthoDB" id="4986826at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16397" checksum="71BF0EDAB7CABEAD" modified="2016-10-05" version="1" fragment="single">EIIQQILENVHQIDKPSLPACRLVCRTFDAITFPLLFYHIPQWLNYEASHRAVLSLAHDICNRPAVMWSPWATAPDGPVDPVWMAIVWKLLVKRDVPGSLAVVGRKGEGVLTAENFAELSGMEEMTENRLRTGQNRFLMHRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW85</accession>
    <name>A0A194WW85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_653320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066202.1">
        <property type="nucleotide sequence ID" value="XM_018212246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW85"/>
    <dbReference type="STRING" id="149040.A0A194WW85"/>
    <dbReference type="GeneID" id="28821972"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653320"/>
    <dbReference type="InParanoid" id="A0A194WW85"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267615" evidence="1">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="402" mass="42491" checksum="63927A265F6D4E03" modified="2016-10-05" version="1">MRSTYIISAFAGLALAAPHPQDIEFDQVDAAPDPTIVTPPVLGASATVSIQPTAAVATVADASVTEVASTNSTETNDKRDFLDFLGKRDGNCAVQPKGTGPTVNTPDDTPASFLAYQPFQTTATNAATPQGYTQSFVNLQGSSQTVSWLGYTTLSSYDTVACASYCDQLDGCQAFNIYYERDPTEDPNATSCPNPPSLTNIKCSRWGVQITADTAVNTGQNRDSFQVVIAGSNGYNKNAPPPAQTGFTGPVELGGAINAPNDPVTNTNTYMGYKFFSFGQVQTYPAGVQACTLACTAQTAYNSRHPPSTGKPNVCNQVVVYVLSDENDPKGIYCAMYSEEWAQNYATNYGQYRGSDYWSVSQAYAYTNATYSAAYGPICAVGGCPSGSYRGGNCGGWGTGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWM1</accession>
    <name>A0A194WWM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066723.1">
        <property type="nucleotide sequence ID" value="XM_018220336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWM1"/>
    <dbReference type="STRING" id="149040.A0A194WWM1"/>
    <dbReference type="GeneID" id="28830062"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738156"/>
    <dbReference type="InParanoid" id="A0A194WWM1"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="58765" checksum="6CE14E5FA157B8C2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXQ6</accession>
    <name>A0A194WXQ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_208058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066819.1">
        <property type="nucleotide sequence ID" value="XM_018205838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXQ6"/>
    <dbReference type="FunCoup" id="A0A194WXQ6">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="GeneID" id="28815564"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_208058"/>
    <dbReference type="InParanoid" id="A0A194WXQ6"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="285"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="578" mass="63934" checksum="8318B447B5B1DAEF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY23</accession>
    <name>A0A194WY23_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_195693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY23"/>
    <dbReference type="GeneID" id="28815465"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_195693"/>
    <dbReference type="InParanoid" id="A0A194WY23"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60481" checksum="8EE17AF6F3105B89" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZH4</accession>
    <name>A0A194WZH4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_721381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
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    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067706.1">
        <property type="nucleotide sequence ID" value="XM_018218641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZH4"/>
    <dbReference type="GeneID" id="28828367"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721381"/>
    <dbReference type="InParanoid" id="A0A194WZH4"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="9"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="503" mass="55298" checksum="110A8D3664E45D75" modified="2016-10-05" version="1">MLKHLTLNATLQGIQSSHNNIPLQHYRGIRYATIPGRFKKATAIDTWDNADIDCTRFGPNCPQNYVDVGYLLRIPESQDDVLNIAQDEFDCLSINVTTPLAETTPPTTLLPVIVWIHGGSQVVSFPPPSHKVSDPSKIVSQSAAIGKPVIFVTFNYRLNIFAFGDGNEVNLALKDQRLAIDWVTKHIAGFGGDKDNITLCGESAGAVYAHAHLCTSAPVKCGILQSGSLYLSPPLPTTRGTAFITSIDQQLRERSGQGLKDAPVADVLRQLAISNVNTLYLQEEPQLKGWEDRLTDVPELLIGDVEFESVIWRAGVESMTASEITAAFTHPKDPTLSQALLQAYHISPTRLAASRAGALDFLTDARFAWPSRTIANARSADALKTFRYVFDQPSPFQASARAHHGVDLLYLFEAYSDTFLTEGQRILGNVVRDKWIAFANGEAPWNESNCFAFGPFGLSAEIDNSGLGERRRVKAWDVLEKTEPDELVRIFFSLAGGRISLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1H5</accession>
    <name>A0A194X1H5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_590394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068189.1">
        <property type="nucleotide sequence ID" value="XM_018209591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1H5"/>
    <dbReference type="GeneID" id="28819317"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590394"/>
    <dbReference type="InParanoid" id="A0A194X1H5"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="47174" checksum="65C05F6609B381C6" modified="2016-10-05" version="1">MISILSQWKIVLLPSTVLYLYLVHHLRFRRSSSLPHKYPYPDRTSYNKMTFRHAWEIHNSLIEYEFPTTFSAATMFALFKAYGIPTISSILRATGQFSSKDTVDKRYTDTGCLLLEAVLNPPASERALEAIARINYLHSPHMASGKISNDDLLYTLSLFALEPARWVKKYEWRELTNLEMCAVGTLWKLLGEALGIKYDVLGDGAELNDGLMWLEALDDWSSEYQERYMVPAESNKQVADATLYHITWKLSKKMKSVGNRVVAALLEDKLREAMMIPKPPQSYYTLINRFISARKFILLHLSLPRMRPKKRLPIASSSGRIHSRKYNIQPWYVKPTFSNRYGLKAWRTWWKGGVLPGDDGGKYFPEGFRASELGPNGLRGRGEKEMGAERSRLEELWSSERGVCPFLVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1M0</accession>
    <name>A0A194X1M0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_753204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068234.1">
        <property type="nucleotide sequence ID" value="XM_018221266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1M0"/>
    <dbReference type="GeneID" id="28830992"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753204"/>
    <dbReference type="InParanoid" id="A0A194X1M0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267773" evidence="5">
        <location>
            <begin position="22"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="645" mass="70309" checksum="D3493DA1E78B230E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1P3</accession>
    <name>A0A194X1P3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_721085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068259.1">
        <property type="nucleotide sequence ID" value="XM_018218613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1P3"/>
    <dbReference type="GeneID" id="28828339"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721085"/>
    <dbReference type="InParanoid" id="A0A194X1P3"/>
    <dbReference type="OrthoDB" id="3556769at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="25323" checksum="B524B1BDB89F4FAF" modified="2016-10-05" version="1">MCDYERGAKMTGKASPMKGIKPLPMVDSGGEECDDDGDSCSGSGGGCIFSFKKDDNDLKTKEIAANCPNKLIFNSTNVATLALCTTLNYLCPSPNPNRTQFETYNNTTGPAPSTCRPYAWDLALDANATGTLTIAGVATASNVWFAGLGPGLSPYNASVVIPAVPLKVTALELPDLVNVKGSLSLSEADRMEKFSVPLLEEIGIEGVDIDLSGTDPPAIDLSFPSFRGSKGFISLVGNIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X203</accession>
    <name>A0A194X203_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_672144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068227.1">
        <property type="nucleotide sequence ID" value="XM_018213263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X203"/>
    <dbReference type="STRING" id="149040.A0A194X203"/>
    <dbReference type="GeneID" id="28822989"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672144"/>
    <dbReference type="InParanoid" id="A0A194X203"/>
    <dbReference type="OrthoDB" id="3504677at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267724" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="149"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="258" mass="28176" checksum="1FDDB250A4182064" modified="2016-10-05" version="1">MPSLRSLLLGFSVAALVASDCTRDTLKTFTDSLVAAQTKGDPTVFANVPSYSENFKTLTPKTGILATPLVIAHNRSSYDTTNCSTYTELIITDPKHPYVLGTQIRYTADASNITKMELLVTEAGDWLFNATGTYYWASKESWDTISVAKRDTRAVIQAAADAYLNIFKDKSVVVPWGTPCDRLEGGSYTGTGKATDSCDVGIPNNLDLTSRRYVIDETVGAVDVFLAFGGVSGRPDSHEFRIESGKIRYVHTLTNMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2E1</accession>
    <name>A0A194X2E1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_784171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068534.1">
        <property type="nucleotide sequence ID" value="XM_018222756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2E1"/>
    <dbReference type="GeneID" id="28832482"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784171"/>
    <dbReference type="InParanoid" id="A0A194X2E1"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="145"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="600" mass="66746" checksum="9C540FA99A2C4781" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2M9</accession>
    <name>A0A194X2M9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_686913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068793.1">
        <property type="nucleotide sequence ID" value="XM_018215390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2M9"/>
    <dbReference type="FunCoup" id="A0A194X2M9">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2M9"/>
    <dbReference type="GeneID" id="28825116"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686913"/>
    <dbReference type="InParanoid" id="A0A194X2M9"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="130" mass="13947" checksum="F0289C8A4C4E21BD" modified="2016-10-05" version="1">MSWQAYVDSSLVGSNQISKGAIYSAAGDSKWASSPGFELSPAEAKVIAAELKDPKTDSKVWTDGFYVNGVRYVATKLEDRSLYGRQGKEGIVVVKTTQAILLGHYPENVQAGNAAVVVEKLADYLIGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X372</accession>
    <name>A0A194X372_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7791 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_133939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068627.1">
        <property type="nucleotide sequence ID" value="XM_018205258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X372"/>
    <dbReference type="STRING" id="149040.A0A194X372"/>
    <dbReference type="GeneID" id="28814984"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_133939"/>
    <dbReference type="InParanoid" id="A0A194X372"/>
    <dbReference type="OrthoDB" id="3563224at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267834" description="DUF7791 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="56"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="437" mass="49617" checksum="9E7DB53FBAEB25FE" modified="2016-10-05" version="1">MKSCGVFLWVTLVVLSLSEGLTDGDRLSDLQKRLDLLPSDLEDLFWRILNSVDLERISQLIQIVRISPESISILELSYADEDDPNFIFKMLTRPVSIATISSRAELMRRRLNACCKGLLEPQGIDFKTDPNATVGYLHRTVKDFLQKIDVWERLLHATSPSFDPAMRLSVSHVAHLKILPTNSRYCIGAEYASQMRDLREFWIAVIHCIWLILRHGPHATEVKLRLLEEVNDIVDEIITRAASNNNSTMAPALYSNCPSTLSGETNIRSFLHIAVRLQIDFYVNVHVSDLQKPDRIQELSFLLRIALTDYECNCDGFEITAPSFSIVEYLLQHGATLDGTNAWHYILGNIPHRSDLLMLLLRYGTDPFDIRLRSGGKALETEVLKLAKTKRDEAMRKGSRLGGREKSAMPEASEPLEDKARSRWSRPISKAFGQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4H1</accession>
    <name>A0A194X4H1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_589295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069425.1">
        <property type="nucleotide sequence ID" value="XM_018209521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4H1"/>
    <dbReference type="GeneID" id="28819247"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589295"/>
    <dbReference type="InParanoid" id="A0A194X4H1"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="12366" checksum="C992E6C02A79B161" modified="2016-10-05" version="1">MLDDRNRTMSSQQYVGEGAWNRGSDIMAWECLLGEQRGGGRVSSYAAPGRASDLTALPKVNIDVGAADFREEDFAYASVLWKCGVQAELDVWPGAFHASDLLAPTAVISVATRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4I9</accession>
    <name>A0A194X4I9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_708433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069097.1">
        <property type="nucleotide sequence ID" value="XM_018217682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4I9"/>
    <dbReference type="STRING" id="149040.A0A194X4I9"/>
    <dbReference type="GeneID" id="28827408"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708433"/>
    <dbReference type="InParanoid" id="A0A194X4I9"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="672" mass="73404" checksum="A61717633CED5DAF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4R7</accession>
    <name>A0A194X4R7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_105896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069528.1">
        <property type="nucleotide sequence ID" value="XM_018205038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4R7"/>
    <dbReference type="GeneID" id="28814764"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_105896"/>
    <dbReference type="InParanoid" id="A0A194X4R7"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="607" mass="67314" checksum="04E1BF2CAF463670" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4U7</accession>
    <name>A0A194X4U7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_686470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069192.1">
        <property type="nucleotide sequence ID" value="XM_018215290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4U7"/>
    <dbReference type="GeneID" id="28825016"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686470"/>
    <dbReference type="InParanoid" id="A0A194X4U7"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16596" checksum="11C7B0B6855AE788" modified="2016-10-05" version="1">MAEDTKPRTFNPEGVPLPPPTYNHACITPLIPGSVDLITLAGLTGVSSWTDSNPKTIAEQAPIAFQKIKTCLLAAGATPRDIVQVKHYIVKETGDPEVDKLDVVERGWGESWMEFMDREAEGHRPPDTVIGVAALATKATLYECEVWAVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5L5</accession>
    <name>A0A194X5L5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_686216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069828.1">
        <property type="nucleotide sequence ID" value="XM_018215235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5L5"/>
    <dbReference type="GeneID" id="28824961"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686216"/>
    <dbReference type="InParanoid" id="A0A194X5L5"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30466" checksum="536A35EA1804F4D6" modified="2016-10-05" version="1">MDLSFITVDPSTPHTHTVVFLHGRGDTAKNFASSLRYSTDSHNRTLSEIFPSFRWVFPQSEIRQCTASPGEKWSQWFDVWNVSNFSDREELQAKGLRESVAGIQRILSSEAAVLGGQWDRVILAGISQGAATSVHTLLNLSLPPVVGGQQVLPRLGAFLGFSCRMPFPGRTLAETRKVLSLDGSPETDEVLRSTPILLEHCVDDPLVLIGNGRGLRDSLRGFGAQVTWKEYPKGGHWFNSPAGIDDVVEFLKNHVLKKPSAGEKLSSQLLPDSMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5T0</accession>
    <name>A0A194X5T0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_619515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069888.1">
        <property type="nucleotide sequence ID" value="XM_018210881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5T0"/>
    <dbReference type="FunCoup" id="A0A194X5T0">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X5T0"/>
    <dbReference type="GeneID" id="28820607"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_619515"/>
    <dbReference type="InParanoid" id="A0A194X5T0"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="15">
        <location>
            <begin position="487"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ15533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114103" checksum="3179B33BF36B6803" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5W5</accession>
    <name>A0A194X5W5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_686287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069926.1">
        <property type="nucleotide sequence ID" value="XM_018215252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5W5"/>
    <dbReference type="STRING" id="149040.A0A194X5W5"/>
    <dbReference type="GeneID" id="28824978"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686287"/>
    <dbReference type="InParanoid" id="A0A194X5W5"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="19796" checksum="7D32E86EB1F56D31" modified="2016-10-05" version="1">MVTQLTINELLERNKAVAAKHEPIPTIDEIAAMGVEPPHIIVLTCADPRCVPHYFLNLKPTDGVLTLRNINGHVAPLLNDILALDTYLGIHEIMIVHHSDCGALIFTDEMVKANLKKQHPNDTKIDNEVFGAVTDIEQSIKDDLAVLKASPYIRKELAEHSFGFLYDIKTGELKRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X652</accession>
    <name>A0A194X652_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_587250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070010.1">
        <property type="nucleotide sequence ID" value="XM_018209419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X652"/>
    <dbReference type="FunCoup" id="A0A194X652">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X652"/>
    <dbReference type="GeneID" id="28819145"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587250"/>
    <dbReference type="InParanoid" id="A0A194X652"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ15655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="49921" checksum="5EC26590738E16E4" modified="2016-10-05" version="1">MSSSSSNVVGVHYRVGKKIGEGSFGVIFEGLNLLNNSSVAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCNRRFSIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFIIGRPGSKSANVIHVIDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTAIKDLCDGFPEEFNKYLSYVRNLGFEDTPDYDYLRDLFTQALKNTGEVEDGEYDWMKLNNGKGWEAMKQHPSQHMLHQPNAVPGASQRELHGTTRAGNSTPGHLTAARLNAAQPPPPSPIKPGMGKTRDRPNAPGGLAPKRSSGAAGGLQDVATPTGSTQAQFQNSSNNLPQRMTPQPNMNAQPQNGRTSEPQMSGFQKLMKTLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7S6</accession>
    <name>A0A194X7S6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_586178</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070509.1">
        <property type="nucleotide sequence ID" value="XM_018209356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7S6"/>
    <dbReference type="FunCoup" id="A0A194X7S6">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7S6"/>
    <dbReference type="GeneID" id="28819082"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586178"/>
    <dbReference type="InParanoid" id="A0A194X7S6"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="593"/>
            <end position="653"/>
        </location>
    </feature>
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        <location>
            <begin position="698"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="792"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="835" mass="92110" checksum="15F3B88BE14D6CCD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7T7</accession>
    <name>A0A194X7T7_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28822847"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669706"/>
    <dbReference type="InParanoid" id="A0A194X7T7"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="325" mass="36235" checksum="53DFD74965485D95" modified="2016-10-05" version="1">MIGTKPAKRGRGRPRKHPEAGRDPSINTPAELAAACPPKIKPRRTKAKAKRFTRPARNSTVRNARRIPGEENERQYSDGIDELDEFAFMDALLNAEDQAYMRGVLDALATQPEHDHECIDNQKTKVEVKAEYQAAEVIKLENTPPEVGEWRLLNVKIEQGEIKLPISVLPDEVNGHDVPSKVLDALGECDMSARSGGTQEVERPADEMIWKLDAIHDCNVNLGATRVYDTDKEMDGLNLLAGSTAEAEPQTNDLVLQDLDAVRDDNVVLNATHFYDADEEDLIGNLVQYQVWHEALQGELPAQASEVTTLGRIRGFMINLIWGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8T9</accession>
    <name>A0A194X8T9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_585926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8T9"/>
    <dbReference type="GeneID" id="28819073"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585926"/>
    <dbReference type="InParanoid" id="A0A194X8T9"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ16585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="283" mass="31295" checksum="AA924F0D636BA628" modified="2016-10-05" version="1">MSGNDSNKSRGSPPKGLPEPEKLPPGLQKLVDRADKEDNFYDELYDGTAPQSTESSIRYAAYASRIRTALLSAQRYVAYTSDIGESFRPVAHPNWVRAAYGVSWAYLVGDVAHEGYKAYCSNQRTMYPSLPRIAAHERYNDAQTATSPDTAAHEAGISLTPQKVLPINDYRTVMTQRAIFQAVASMGLPAFTIHSIVRYSGRAMKNVKNVRVRTWGPIGLGLAAVPALPFIFDEPVEKTVEWIFHKGFETFGGKEAVGDSPATGREQILEQKQRAAVKKEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X954</accession>
    <name>A0A194X954_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_707630</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070672.1">
        <property type="nucleotide sequence ID" value="XM_018217620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X954"/>
    <dbReference type="FunCoup" id="A0A194X954">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X954"/>
    <dbReference type="GeneID" id="28827346"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707630"/>
    <dbReference type="InParanoid" id="A0A194X954"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ16317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="451" mass="51146" checksum="2E690B0EC840B69C" modified="2016-10-05" version="1">MAKPRRGVKFNHRNGHSSGTDGRRSSFSDISEAASEPGSPDKTTNGGDTIVVQQPGISEYEKKKQTFLTRALWTFIMIGVFFGAMFMGHIYIIAIVTAVQIISFKEVIAIANVPSRARRLRFTKALNWYWLATTMYFLYGESVIYYFKHIVLVDKVLLPFATHHRFISFMLYIIGFVFFVASLQAGHYRFQFTQFAWTHIALYLIVVQAHFIMNNVFEGMIWFFLPVSLVICNDIFAYICGITFGRTQLIKLSPKKTVEGFVGAWILTVLFGIGMTNVLMRYKYFICPVNDLGANMWTGLECVPNPVFTPHIYHLPIWFPIHKSFSMTPMQVHILVFATFASLIAPFGGFFASGLKRTFKIKDFGDSIPGHGGMTDRMDCQFIMGFFAYMYYHSFIAVYKVSLGGVIETAITGLTPEEQMELVKGISKHLFNQGVIAEGVLECLNGAVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9S4</accession>
    <name>A0A194X9S4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TFIID-18kDa-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_684920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071271.1">
        <property type="nucleotide sequence ID" value="XM_018214985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9S4"/>
    <dbReference type="FunCoup" id="A0A194X9S4">
        <property type="interactions" value="1016"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9S4"/>
    <dbReference type="GeneID" id="28824711"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684920"/>
    <dbReference type="InParanoid" id="A0A194X9S4"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="314" mass="36020" checksum="0BB9924179F4F24F" modified="2016-10-05" version="1">MTDKMAKYRTEIQQMMYVSGETAEASPETTGMIEEIVRQQVIEMLRQCTEQASRRGSRSISTDDLIFLIRHDQAKVSRLRTFLSWKDVRKNVKDSDDKGGDADIGPTDDPAGAVPGGPVVDTAKKNKKAKVGLPWEVPSFYNQEVPEREEEEDEDEEEMNYATLQRLKKADERTKIMTKEEYVTWSEYRQASFTFRKGKRFKEWAGFGVVTDSKPNDDIVDILGFLTFEIVQTLTEEALKIKEGEDLVKDKSGGEQAGKKRKIQGLFDPPSEGRTPVEPRHIQEAFRRLQQRPNKQRAMCNFTRGLNRTPLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9Y6</accession>
    <name>A0A194X9Y6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_571485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070942.1">
        <property type="nucleotide sequence ID" value="XM_018208595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9Y6"/>
    <dbReference type="STRING" id="149040.A0A194X9Y6"/>
    <dbReference type="GeneID" id="28818321"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571485"/>
    <dbReference type="InParanoid" id="A0A194X9Y6"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="34601" checksum="6935E3960DF62B63" modified="2016-10-05" version="1" fragment="single">ARAWLNDCITTHPECRSNTSRKLPTRVINVGTSNSEVRLVETNGSEGRYATLSHYCGKIHPPLTENETLEDRKQGIPVEDLPKTYRDAIMVTRGLKLRYLWIESLCIIQDARDYIKEMAAMQDIFANAVINISADDSLDTIDDSCGLSHTKDGHQHILRTRASVLQERMLSRRILHFSAYELAWECDTNVRCECSSHIRPASQRPMRKCIREQNSDAPTNINYNNLWSDICSTYSKLNLGRDFTTLNTIAGLAFRVGERSSKTYVAGLWKEDLPCGLLWRTAATVKRRRVDFPTWSWASSTGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAV0</accession>
    <name>A0A194XAV0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_733151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071643.1">
        <property type="nucleotide sequence ID" value="XM_018219765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAV0"/>
    <dbReference type="GeneID" id="28829491"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733151"/>
    <dbReference type="InParanoid" id="A0A194XAV0"/>
    <dbReference type="OrthoDB" id="3563591at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31950" checksum="3B97FCC15AD85E97" modified="2016-10-05" version="1">MAYKGKNDNGKKGGNKGAGAKSGGNGGGKKHCDNCGPNNTHVTADCFKNKKRSNDTKQNPKTKDSAKPPSRPCSHCGGPHYDNQCPNNTGGQTNKPQNGKTPSRPCKHCQQSGHFDSACPTLTNNASSTVPWQNQNQPFNQPCPSCGQAHHCNQCPNRPQLPQGQYVQTTTEVYGQLGALINALQANPSQANAIIGEWQGVYGQQQQQPAAPIFQQQQPQAPAFSLQPLAVWHNNGEDVHFAQPYEETSMFGQQAEQRGTYMQQWHTNSTNFGAVPDAMDRDGDVVMSEWDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAX7</accession>
    <name>A0A194XAX7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_718049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071681.1">
        <property type="nucleotide sequence ID" value="XM_018218387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAX7"/>
    <dbReference type="GeneID" id="28828113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718049"/>
    <dbReference type="InParanoid" id="A0A194XAX7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="22608" checksum="EC11E6C7AC8EA188" modified="2016-10-05" version="1">MDDVLETLGLVTTEEDVGATTEELDVLETLGLETTGVLVGATTEELDVLETLGVVTTVVLVADVLRTDVLEVLLDVVAPLLATPAEEEAAQFHSLLCGKRGILLFIGTAISEASSRDSVSRLSSCACRAAIPFATLLCQNVSGYGAVKSSEYLLQKERGRQEREGCERLHGWRWLASNLSGESALFSRGLDFTIYDFEPWLWTLGPSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB02</accession>
    <name>A0A194XB02_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_718649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071287.1">
        <property type="nucleotide sequence ID" value="XM_018218429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28828155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718649"/>
    <dbReference type="InParanoid" id="A0A194XB02"/>
    <dbReference type="OrthoDB" id="3564998at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="584"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1457"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1482" mass="170289" checksum="E4CD6443F6FDB2C0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB20</accession>
    <name>A0A194XB20_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_644812</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071726.1">
        <property type="nucleotide sequence ID" value="XM_018211846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB20"/>
    <dbReference type="FunCoup" id="A0A194XB20">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XB20"/>
    <dbReference type="GeneID" id="28821572"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644812"/>
    <dbReference type="InParanoid" id="A0A194XB20"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="60"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="277"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ17371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="51353" checksum="3560DA0C77E31920" modified="2016-10-05" version="1">MLRSCSQNGSKIFRLTSRVGHRPLQRYNSAPTSYVRQFGNAPPWRPASTLDEWVGREARPISLRQLMVFGRSLTEARLISSANYVRTELPTRLAHRIRDMQTLPYVVVTNPHISQVYELYYKAFESLRRVREIKTLEDNESFCKKIAQTLQEHLTVIPKLAMGILECRDLMRPEDMDKFMNTILRSRISRRVIAEQHLALTETFNSPWHFPSTTSTLDPSTEFVGEVFLRCNAGEVVRRCGDAVTSLCAAAYGPTVSLPTISLSGHTSATFPYILSHLEYIIGELLRNSIQAIVERQTPSPPPIEVTVCEAAQHVIIRVSDQGGGIPRDVLPHIWSFSKGPRSDQRLENLRGVPKMAATLQELRVSNDLPPGLSTSKKEAPKTEGEKAHDSSLSTLSSRPPNLRLGMGLPLSRVYAEYWAGSLELHSLEGYGVDAFLQISKLGNKNEQLTMRASMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBA5</accession>
    <name>A0A194XBA5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_734034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ17042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018219870.1"/>
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    <dbReference type="OrthoDB" id="784962at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <property type="entry name" value="Bromodomain"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BROMODOMAIN_2"/>
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        <property type="entry name" value="BTB"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
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        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ17042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49081" checksum="4CCFEDDC86950409" modified="2016-10-05" version="1">MSTEVESESSLSMAQEASPDLEEAQPDMLPENMDFTTSPLFLDSDSSDMVIVHLGVSPSMLSLLVHRHIVSEKSSILSLLLNPEESQPPEELHLPDDDPQLFIYLLNYIYTNAVLPSLTPSIVTTKSLTPATATHTPSPSINGPTKDHLIKTFKSLSTNPTYTPFHRPFTATIPTRSALWQHRIVTDIDFSTMQSKLVQGIYRDLRSIDRDFDLIYNNQLSFHGSKHQYTDLADSFRALYREKTAELRPKGSEGDGGRGVLKMPKTHLQQQFERMAELAVGLPVEVLLGLEVLATKYHIPTLQDLILTSILSSHLTSSTFLTLPQINTYYPLSTPNSPLRKYILKTISFHLFSKTALPTDTIGDLNRTENLYQLIATNEELGMEVFGMLRGRGGIAFGDPRKGGFCEFHCHGRDGVCGLGGEVWRGVGRKRAAVEMEGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDP7</accession>
    <name>A0A194XDP7_MOLSC</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_644360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072653.1">
        <property type="nucleotide sequence ID" value="XM_018211834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDP7"/>
    <dbReference type="FunCoup" id="A0A194XDP7">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="28821560"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644360"/>
    <dbReference type="InParanoid" id="A0A194XDP7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="123"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="285"/>
        </location>
    </feature>
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        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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            <end position="392"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="569" mass="60321" checksum="62F03D095B7DDA1A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDW7</accession>
    <name>A0A194XDW7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_781438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072735.1">
        <property type="nucleotide sequence ID" value="XM_018222483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDW7"/>
    <dbReference type="STRING" id="149040.A0A194XDW7"/>
    <dbReference type="GeneID" id="28832209"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781438"/>
    <dbReference type="InParanoid" id="A0A194XDW7"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="563"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116121" checksum="FA8F1742A3DBD79F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE98</accession>
    <name>A0A194XE98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_667601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072865.1">
        <property type="nucleotide sequence ID" value="XM_018212985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE98"/>
    <dbReference type="STRING" id="149040.A0A194XE98"/>
    <dbReference type="GeneID" id="28822711"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667601"/>
    <dbReference type="InParanoid" id="A0A194XE98"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="373" mass="41400" checksum="A0581F1D9EA30BD0" modified="2016-10-05" version="1">MASSQSARKLRVGIVGAGDVAQVVHLPTLALLNHLYSVISICDISQQTVDHAAARFNVSHKTINPSETISHPDVDLVMILAADEYHEPLCISALKAGKLVFIEKPITLSMPSVQRILEAEKATGGNKIFVGYMRRYAPSFTEAFLREVASIPRIMYARSRDIIGQNEHFVNQSGTSPRKYTDFPANAAQDRKVHLDKLFAEAFPGRAVSEKDIQYCRFLGSLGSHDLSLMREALGFPESVTGVSANEPFYSAMFNYRNKSGEPFSVTYESGIDHVPRFDAHLAVYGERKTVSIQYDTPFVKGLPIKVKVDEFNEAGESSSSEILSSFEDPYTVELKEVYECFVNGKAIKTTAADASMELQLYDMMYKQLARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEC0</accession>
    <name>A0A194XEC0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_642881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072878.1">
        <property type="nucleotide sequence ID" value="XM_018211773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEC0"/>
    <dbReference type="STRING" id="149040.A0A194XEC0"/>
    <dbReference type="GeneID" id="28821499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642881"/>
    <dbReference type="InParanoid" id="A0A194XEC0"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="35309" checksum="CDAC76EA60575BF4" modified="2016-10-05" version="1" fragment="single">MNKAREWLGKCKHSHNRCSEDVERSLPTRLLHFKEGVLKLVSTTKLDTKTPYAALSHCWGKIKILRLLKENFETFHTSVPISELSRTFQDSLKVLTELGLEYIWIDSLCIIQDDAQDWEREAVKMSAVYGCSEITLAASSSEDGSQGLFYDRQLPAPRLCQLYIGNSTTFDVIPFQHWSVALSRLVLSTRAWAYQERRLSPRVLFFTSTHLAWQCQTWGAEEWKTEGVDKVSSFFNIQSSPHADTFWDETIKEYAPCKLTFWSDKLIAISGVAKRRQITVGGEYVAGLWREGIERQLCWITVSRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEV5</accession>
    <name>A0A194XEV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_557500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073053.1">
        <property type="nucleotide sequence ID" value="XM_018208399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEV5"/>
    <dbReference type="GeneID" id="28818125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_557500"/>
    <dbReference type="InParanoid" id="A0A194XEV5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="243" mass="28084" checksum="568DE59523861035" modified="2016-10-05" version="1" fragment="single">APRGPPTVNLVLATLAAKPHHWTESLTIPSLAIIPYIADDPNAQYHPPANKGNEAISYLTYLHDFYDILPEISIFIHGSDSSWHIDGVLAHSTKEALNTLDLEEVRRRGYLNLRTSWANACPVWINTSIQIGDERYDEKLREEEPFMRAAIEAIFPNKKVPMALASPCCSQFAVTKERIRRIPKEQYKRAIDWLMSTELESKVSGRIWEHLWHWLFLGKDIDCPSEWRALCVWYHLCFEDEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEZ2</accession>
    <name>A0A194XEZ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UEV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_706842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072692.1">
        <property type="nucleotide sequence ID" value="XM_018217554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEZ2"/>
    <dbReference type="FunCoup" id="A0A194XEZ2">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XEZ2"/>
    <dbReference type="GeneID" id="28827280"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706842"/>
    <dbReference type="InParanoid" id="A0A194XEZ2"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        </source>
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    <sequence length="540" mass="59762" checksum="F2AA1316246F298F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
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        </source>
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    <sequence length="512" mass="56179" checksum="20326EFB6EF24FA7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFB7</accession>
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        <recommendedName>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ18863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38333" checksum="6450770876FF799D" modified="2016-10-05" version="1">MEHLTIQEISSPPEFTFPQSDVRLRITYKGAPAYAHVCSHAMILASDVWKVFLFPPWSNQATAEPVQDLDFTEDNAEALLVLLCVVHLRFGDIMYDSPPKQVLIDLAFLCDQYFCHHLIRPWAGNWIDRQFGFDIAENSASKPDYFEKGVYWLFNENRVYNLPEFHRDWPLPKGLMRTIMIARNEAIDALLAVIHEYQADLDEREAICSKHHQKCKRFSKSGLYHQKTAADSISVAQITRTKFNVARQYHGEVIRDRELRLHDEVKEKINTIRNDHWKTPWETVKPLARPDVRKGDNRLRIENITGEWRKGDPSNAKHFTGATARYRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG88</accession>
    <name>A0A194XG88_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_642085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073504.1">
        <property type="nucleotide sequence ID" value="XM_018211740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG88"/>
    <dbReference type="GeneID" id="28821466"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642085"/>
    <dbReference type="InParanoid" id="A0A194XG88"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="264"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="49610" checksum="86F929D8986DA6F5" modified="2016-10-05" version="1">MDNSRSSQRNIELDGWNRRTTSNEADGSLILDNNGGVQDVEGRNIVIQQLKPVDGGPDAWKVLIAAFIFEALLWGFPISFGVFQDYYSTLPQFAGVNSKIALIGTLAQGLSYLGAPISAMVTKRFPKYHRLQIWIGWPVCLGGLVAGSFATTVPSLIATQGIMYGIGFITLTYPIISMVDEWWVQRKGMALGLIASASGASGAIMPFIISAMLNKYGYQTTLRAIAVAMALLTGPLIPFLKGRLPPSERSAIAKTNWSFLRKPLFWIFGVSTLIQGLGFFFPALYLPSYATAIGLSSTQGALVLAIMALAQLIGQFAFGFLSDKKLSVSTLAIFCSFMATIGSFAVWGMSKSLGLLILFSIIYGFFGYAFAAMRAGMGKAVSDDPSAVVATYAILVFLQGIGNVLAGPISAALLERNVRLNVYGVERFRSLVIFTGTCMSASGFVILGWFLRPSKVFAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGZ5</accession>
    <name>A0A194XGZ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_773934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073830.1">
        <property type="nucleotide sequence ID" value="XM_018221952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGZ5"/>
    <dbReference type="GeneID" id="28831678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773934"/>
    <dbReference type="InParanoid" id="A0A194XGZ5"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF147">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="40367" checksum="C7718A125479C1A3" modified="2016-10-05" version="1">MTYISPAEEVAAGLWTLFAGTTVFLGLRIYCKFVRRAGLWYDDQTLILSWLVLMSTDILISIEFATGYVTGHWDDRMHILINTSSCGTLVGQALSKIALGITLLRMADRKQAAILWFCVGSMNVYMLVKVFFQWAKYCGKDDYQNWYRLQGPCVGYVFEERLKVGGNIYNIVMDFVFAMFPWWITWKLDMRRIEKIALCGAMSLGMLVAVSSAVRTAWVSRPIMHVHDEHYIWRNGMSNIWFSAEVAFTIIVQCIPILRPFLREIRTTITSKHLSEDAKASTWTQSSDPEVIALSDIPETRKESVSSIVITEPVVPEDWRISGSDVLSPHSVSWVEFDDEHEEKGLRPPPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHU7</accession>
    <name>A0A194XHU7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_581145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073702.1">
        <property type="nucleotide sequence ID" value="XM_018209097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHU7"/>
    <dbReference type="STRING" id="149040.A0A194XHU7"/>
    <dbReference type="GeneID" id="28818823"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581145"/>
    <dbReference type="InParanoid" id="A0A194XHU7"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="111"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="37367" checksum="0D8F394AD3F6AA32" modified="2016-10-05" version="1" fragment="single">HDNLALAVISQYSIAKAVPLDQSISMIEVSKKTGLSEHLTRSILRHAVATGIFHEPVPNHIAHNGLSKLLLEPKMAGWVHHTTNDVVPAASMVIESWRRFPDSNEPNETGFSLAGGQGKTLFEYLAENAEARDRFSLAMAGLTASGGYDANDLVHGYPWTNITSGATIVDVGGSDGTMACALASQYSGFRLIVQDLEGVAAHGKEALLPSLRDRVQFQAHDFFHPQPVEADVYIIRHVLHNWSDKYSVQILRHIVAAMKPTSRIIVNDAVMVEPQETSAEQYWNMSAMNLQMITLLNAKERTLHDWTELFAKADPRLKIATVHKPTGSEMSIIEVVLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XII8</accession>
    <name>A0A194XII8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_495585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073937.1">
        <property type="nucleotide sequence ID" value="XM_018207924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XII8"/>
    <dbReference type="STRING" id="149040.A0A194XII8"/>
    <dbReference type="GeneID" id="28817650"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_495585"/>
    <dbReference type="InParanoid" id="A0A194XII8"/>
    <dbReference type="OrthoDB" id="3557131at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="16666" checksum="E403A8F623053028" modified="2016-10-05" version="1">MSSFNTAIHVGFWTNYSKGVILGSTLTLNNRNAGILIAAIAIFIQLIGGQSWGIVRFIAHQLCTTTQSRDGLHHQQQAILRNNNSDISTIWMFARIGYAWHSRCPKSFQKSISLILIGTFHLLVFDAASILASHITTTDSEVLVASSPYCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIX3</accession>
    <name>A0A194XIX3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_682864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074419.1">
        <property type="nucleotide sequence ID" value="XM_018214586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIX3"/>
    <dbReference type="FunCoup" id="A0A194XIX3">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIX3"/>
    <dbReference type="GeneID" id="28824312"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682864"/>
    <dbReference type="InParanoid" id="A0A194XIX3"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="29724" checksum="FA5215E8A000E5E5" modified="2016-10-05" version="1">MADAVTLEFKGRIAVITIDDQKKLNALSQDGYYQLAAYMKEVAQHDEVFITVLTGKGRYFSAGADVSISRSQPDGTDLNRHWLKSFVSNNLFVTNTFQTHPKILVTALNGPAIGLSAALVAFSDFIYCVPSTFLLTPFSSLGLVAEGGASRTFVQRLGISKANEALIMSKRITADELLQVGFVNKIFDCGKDEDEKFRKLVFEEIDNRLGEHLIGDSLTKIKALIRKPERDIMDAQGVAEVFGGLERFSAGIPQEEFRKIASGEKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ07</accession>
    <name>A0A194XJ07_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_640955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074097.1">
        <property type="nucleotide sequence ID" value="XM_018211690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ07"/>
    <dbReference type="STRING" id="149040.A0A194XJ07"/>
    <dbReference type="GeneID" id="28821416"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640955"/>
    <dbReference type="InParanoid" id="A0A194XJ07"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="29742" checksum="A6A25A2839B07E94" modified="2016-10-05" version="1">MAKVYRDDSLDEAEPLTGEDGAIGRVWKSEKVYLESRLRELRPRWIWFAHAVLLSISIGSLALSLYIRLSTQSNSIPVTYLPAQSAIKYEIKQFDLPPVPEGPFVGKGPEVDASWDYITNSIGDTMVSREEMIKMNLDPNGALEITDPATGKRGFRVAIEVFHQLHCLDLLRQSHYKSHYAPLGGDTAAPVHDLTGHLDHCIDALRQFVMCQGDVNIFAFRFPFNDGDPWPDYSTPRVCRNYESIRKWAVDHTVAQGEDEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ79</accession>
    <name>A0A194XJ79_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_612335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074534.1">
        <property type="nucleotide sequence ID" value="XM_018210612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ79"/>
    <dbReference type="STRING" id="149040.A0A194XJ79"/>
    <dbReference type="GeneID" id="28820338"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612335"/>
    <dbReference type="InParanoid" id="A0A194XJ79"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="38"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="148"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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        <location>
            <position position="176"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KUJ20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34084" checksum="9660DFFA7BF06479" modified="2016-10-05" version="1">MITPVLRKQLLQSTKHARSISSSPIVAAQEVKRLGVIGAGQMGLGIALVAAQKAGVPVTLVDTSQASIDKGLKFADKLLAKDVSKERITQEQSDKIRSLLTPYTSMDALSEVDFVIEAVPEIPSLKMSIFENLAQICPPHAILATNTSSISITKIAAATTKDPKDTSASSRVISTHFMNPVPIQKGVEIITGLQTSQETIDTAIAFCKAMGKIPSQSADSPGFLANRILMPYINEAIICLETGVGGRDDIDAIMKNGTNVPMGPLQLADFIGIDTCLAIMKVLYEETGDSKYRPSVLLRKMVDAGWLGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJE8</accession>
    <name>A0A194XJE8_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_715681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018218223.1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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            <end position="812"/>
        </location>
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            <end position="54"/>
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            <end position="203"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="1073"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118360" checksum="E9F643902EFA12EF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKT5</accession>
    <name>A0A194XKT5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_666377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKT5"/>
    <dbReference type="GeneID" id="28822629"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666377"/>
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    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268358" description="GEgh 16 protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="20311" checksum="E8DD9EF74EBF09A5" modified="2016-10-05" version="1">MYISSLVGFGLLSLASAHCLISTATGDLGGNGTGLGVAANGINNQGDVTVFKAATGFGATGAAGAVNPATDLAAQLKITGSTIPQVSANAGVVTMTLHQINADGAGPMTCSVSTDASGKAFTAMTITTNVPGTNGKSTAANQDFPLVASLPAGTKCTGTVGALSAVCAVKCANPAGPFGSVVLVQQAAGKKVREVGGTLAARAKKGAVKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL80</accession>
    <name>A0A194XL80_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/FMN-dependent oxygenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_640727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075204.1">
        <property type="nucleotide sequence ID" value="XM_018211676.1"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="20"/>
            <end position="533"/>
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        <location>
            <begin position="89"/>
            <end position="263"/>
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            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ20849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="60238" checksum="822D4C604B8015CE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLQ1</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_550546</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="23"/>
        </location>
    </feature>
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            <end position="619"/>
        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="737" mass="81710" checksum="38C4B8AC76BFE3FC" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM25</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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    <dbReference type="GeneID" id="28824247"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
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        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNL0</accession>
    <name>A0A194XNL0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214215.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28823941"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="Stn1_N"/>
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        <property type="entry name" value="Stn1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="34108" checksum="6DCE8665C6C23B4B" modified="2016-10-05" version="1">MTSALPEPGNLTIYPDYCQSLSPTIGKWVPLSAIDVSGLRDVGVYCEQRKLYHFLNHPVKWVKITGVVVAIDEVREKKENKDKKIFTLDDSSGVCVEVTVPAPPVFEAPDAGKKHLGQLAKLQEGKGDKKEDSTPSTENPVVPWAEIDVGTVIKVKGRVNMWWKEFQVEGVKIEVVRGLDAEVRAWDEVREFRETVLGVPWVVGKEEEERCRKVRERELRRAKKRPREEKGKARVEERKDKVQRGGEVRKRKDLERVQKLDGVVKRRKDTEGESLGSKNKINYPSMAVRKAAAGKYDALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPY9</accession>
    <name>A0A194XPY9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_762181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076581.1">
        <property type="nucleotide sequence ID" value="XM_018221569.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XPY9"/>
    <dbReference type="GeneID" id="28831295"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_762181"/>
    <dbReference type="InParanoid" id="A0A194XPY9"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="29644" checksum="316FA97925993BCD" modified="2016-10-05" version="1">MLVEDSCRRDLTLGKDKLLAIAGVAAQMHHMYGGLYVAGLWSDTIISDLTWKRDDTPGLTSYSKPVGSLDVPTWSWACTSCPIRSNTIHLFDFDARLLECGIRPKFKNAPFGDIEGRSLVLSAKMVKVERSLRFDDWSCSIVLDKESCDQEIPYPKDHSQLLKLLDREREERWCMLLGHRKLSKFEKMPRRPVGLILAKSKDCFERVGLFEGEWTGPNPASGKANFTLQFALVSTSTSPDEDTKMIAQDVAISILNYAEPHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQD8</accession>
    <name>A0A194XQD8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_762715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQD8"/>
    <dbReference type="GeneID" id="28831305"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_762715"/>
    <dbReference type="InParanoid" id="A0A194XQD8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="455" mass="51295" checksum="8D69FEF3F1078E96" modified="2016-10-05" version="1">MVDNAHKMPQLRTSLKSSGSGTSESAWDLEYHVSHLAAMRNMTKKVLKEQFQDLGLVPEGEDAGRWWKEWEDTMRAVLEPSTSSNGSYVLKKDMWARVTPEDYPYKTQKDRKKAEARKVKNIRVDNFGFLESEPEERMEISQTRTRKRPADLKAAGPANESSSSKSVARMTQTSPSLNAGSSRATVTPQGDIAIQLAQRLTSREASSTTITDTIEAKQNQETLKTAERMERINQCLGEHQPTVAGVGEPNQDLVPEPDALLERQETPQQHLVLKLKISKRKLEKQPDSDRPSKSQKSSHQVSSSAVDGRSTQPSDFREKFEELVVEVERENHGLKEEINKMKLAGETSQQKSEERVKELEALNSNLRDDVSNKDGVIKQYEADLTEEKSKSSALQIEVDGLKEAAANSLVQKLQSEVERLESEHETMIKDKLSAEREIERLKAIEIKYNAAGKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRB2</accession>
    <name>A0A194XRB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_777745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077046.1">
        <property type="nucleotide sequence ID" value="XM_018222161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRB2"/>
    <dbReference type="GeneID" id="28831887"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777745"/>
    <dbReference type="InParanoid" id="A0A194XRB2"/>
    <dbReference type="OrthoDB" id="3597252at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ22691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="647" mass="73131" checksum="664092307B8761B3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRN4</accession>
    <name>A0A194XRN4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_635005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077305.1">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GABA PERMEASE"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KUJ22950.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
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    <sequence length="521" mass="56418" checksum="86D8164868A0D4F7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSH2</accession>
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        </submittedName>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="KUJ23091.1"/>
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        </source>
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</entry>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ23305.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="252" mass="27907" checksum="BA7F5F7CA4E4A5F4" modified="2016-10-05" version="1">MAMHGHSAACCSIPPIVSKGYEPKGKYETIGGLKTYVTGPADATKAILYIYDIFGYFPQSLQGADILSTADDKTKYQVFMPDWFEGNPADISWYPPDTKEKGEKLGNFFQTTGAPPATAAKVPKILKEIESKYSSINTWGVVGFCWGGKIVSLTTSTTSTPFKAGAECHPAMVDPSEAENIKIPLCMLASKDEPKDDVEKFEKNLKGEKHVEIFGDQIHGWMAARSDLEDQRVKSEYERGYKTLLEFFGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT52</accession>
    <name>A0A194XT52_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
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            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_606222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018210416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT52"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_606222"/>
    <dbReference type="InParanoid" id="A0A194XT52"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="17626" checksum="714F15E535BD1E90" modified="2016-10-05" version="1">MATNIALETTMGTIIVELYNDHAPKTCKNFSTLTQRGYYSDILFHRIIPNFMLQTGDPTGTGRGGTSIYGDKFEDEISTSLKHTGAGILSMANSGPNTNGSQFFITLAPTPWLDGKHTIFGRVTRGMGVVKRMGLVRTGADDRPAEEVKIVSARILEGDADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTM5</accession>
    <name>A0A194XTM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078025.1">
        <property type="nucleotide sequence ID" value="XM_018205065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTM5"/>
    <dbReference type="GeneID" id="28814791"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_110"/>
    <dbReference type="InParanoid" id="A0A194XTM5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19013" checksum="A370FCB028F41A6A" modified="2016-10-05" version="1">MLSFSGVYLSRQLFVTFPCILNISNRLKLKLKLKLKLTLLHRCSLYLTCTPHHLSVSCHVQTSRISQFVASVLQVFKQSTDSHNQLNGTLMHPISTPPLPIALSWVSQHVSDAASSMMAASKTCLALALAHRVFTARMADGGVTALSDGTCNCTCTQGIRERPLLTFTHSRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTT9</accession>
    <name>A0A194XTT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_680290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077911.1">
        <property type="nucleotide sequence ID" value="XM_018214044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTT9"/>
    <dbReference type="FunCoup" id="A0A194XTT9">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XTT9"/>
    <dbReference type="GeneID" id="28823770"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680290"/>
    <dbReference type="InParanoid" id="A0A194XTT9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="79"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="609" mass="67090" checksum="098CCC63B2249155" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUN1</accession>
    <name>A0A194XUN1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_563532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078099.1">
        <property type="nucleotide sequence ID" value="XM_018208497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUN1"/>
    <dbReference type="GeneID" id="28818223"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_563532"/>
    <dbReference type="InParanoid" id="A0A194XUN1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32869" checksum="E2FD8E25567C063F" modified="2016-10-05" version="1" fragment="single">VLDALDEFGECLDLMELIQEINEWNPGAVSILATSRRYPEIEEEIIELKPVQINIQSSLIDSDIRTYIQTRLQGKGRLRRWCRDETIKSKIQQTLVEGAKGMFRWVACQMDELDRCLTLGSLETTMKSLPDTLDKTYERILLGIDKRYKSQALTALRWLAFAMRPLTIREVAEAVHLFSCEATIGDVGDESRNRLSDPNDILLICSGLITITEELQPDADPIGYFPDISEPDMRIIQLSHFSVKEYVVSDHAKLGPASHYHLVEPSCHTYITHCCVSHLLQYRDIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV70</accession>
    <name>A0A194XV70_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_679345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078463.1">
        <property type="nucleotide sequence ID" value="XM_018213851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV70"/>
    <dbReference type="GeneID" id="28823577"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679345"/>
    <dbReference type="InParanoid" id="A0A194XV70"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268633" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8257" checksum="DED25AC11FCCC516" modified="2016-10-05" version="1">MWCNLCGRSLSTVSCCLLLLLRVPPYTFVCSSQGLLVIHYRSKKAGQPTSKVKIEEETRWNKIALGWSLLTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVE7</accession>
    <name>A0A194XVE7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_692973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078553.1">
        <property type="nucleotide sequence ID" value="XM_018216606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVE7"/>
    <dbReference type="GeneID" id="28826332"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692973"/>
    <dbReference type="InParanoid" id="A0A194XVE7"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="464" mass="51069" checksum="D4E39888DEB56691" modified="2016-10-05" version="1">MAATARAPRAEGDISSVFASLSGSAPQPLPDRFADIKTSLIQGREKEITASWQRLLSTLRSEIDQITTHGSSIIPEIEFSEINNFSRVQPFTRSLKKRGVAVIRDVVPESEALSWKQEIRDYIRANPQTKAFPKDNKAVYELYWSPGQIKARAHPNVLETQKFLMSFWHTDSDPAAKISTSHPVSYADRLRIRMPGDAGFALGPHIDGGSAERWEKNGYGLGAVYDKIFEGRWEEFDSWDASGRVNAESDLYNGAGACSMFRMFQGWLSMSNTGAGEGTLLVNPLFNLATAYYLLRPFFSPKMGDVGKSGFLETENWELDPVQSTALQGATLGCAQELTTALHPHLELEKSMVSVPNVKPGDYVAWHCDMIHAVDGIHGGKGDSSVLYIPVCPLTEANARYLVTQREAFKSGTPGPDFPGGVGESQHVGQMKENDIKNAGGEEGLKSMGLKSWEPMLHLQVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW49</accession>
    <name>A0A194XW49_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_679428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078594.1">
        <property type="nucleotide sequence ID" value="XM_018213869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW49"/>
    <dbReference type="FunCoup" id="A0A194XW49">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XW49"/>
    <dbReference type="GeneID" id="28823595"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679428"/>
    <dbReference type="InParanoid" id="A0A194XW49"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ24239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="198" mass="21437" checksum="3D4E3240918BCB58" modified="2016-10-05" version="1">MTSIVRPAMLQKTCFAAASRRAFSTKLSSNPATNPTSVLSRKVVRNTFARDAVPGSMRVAAFHASGRRSLLPALPQVVQGTANDPAPVPTPSPSHGSYHWTFERLISAGLVPLTIAPFAAGSLNPMMDAILCGTILIHSHIGFESIVIDYIPTKRLPKTRVLFWWGLRAATVLVGVGLYEFETNDVGVTEAIKRIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWW2</accession>
    <name>A0A194XWW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_745461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078899.1">
        <property type="nucleotide sequence ID" value="XM_018221069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWW2"/>
    <dbReference type="GeneID" id="28830795"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_745461"/>
    <dbReference type="InParanoid" id="A0A194XWW2"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="83"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="3">
        <location>
            <begin position="330"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="451" mass="49808" checksum="216E380427C66A5B" modified="2016-10-05" version="1">MATLIERFQALGPSISRVLSASGSAGAAIGVLHHGKVIHTAGYGFRDVDPELKMDEETVVSFFLLTNAMTASTVGVLVKENSVSGLALGRFLDQRSLKPLGMTRMSVVHPEGEGGEENISEGYVALSDGSTTRIERPFAGDDKIMFGAMGVNSCVKDLLTIYGVLLHAAADQFSGGTTVMKDSLFKQIQTVFSAHTPTGNPTLLNRSYGFGWHRSQLPNQVGASGENKRLILSMPIIARGTNSTTVLYHDGNSTASQNWIILVPEAHSAIIVLTNTMANCDASNWIACMLLDTLLDSPDKNDFEDLSIIAAKKNVDMWKELHSSLEKGQKPGTTPKPLGRYVGKYWNNFGNWYLEVYLEADELRMAFQSDREYVHALRHYHNDIFTLLLMQDENAEIGRYPSTGPGPWLLKFVVEEDTIKGMNWNSNGVEMNIFRKVVLLFSSLYFQRNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWW5</accession>
    <name>A0A194XWW5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_605243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078904.1">
        <property type="nucleotide sequence ID" value="XM_018210387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWW5"/>
    <dbReference type="FunCoup" id="A0A194XWW5">
        <property type="interactions" value="1084"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWW5"/>
    <dbReference type="GeneID" id="28820113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_605243"/>
    <dbReference type="InParanoid" id="A0A194XWW5"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ24549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118041" checksum="6B9AE2E0C219CA89" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX01</accession>
    <name>A0A194XX01_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar assembly/sorting protein-like protein VPS8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_727328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078652.1">
        <property type="nucleotide sequence ID" value="XM_018219140.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XX01">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XX01"/>
    <dbReference type="GeneID" id="28828866"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727328"/>
    <dbReference type="InParanoid" id="A0A194XX01"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="718"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1262"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1584" mass="175000" checksum="6CF6013040149EE5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX54</accession>
    <name>A0A194XX54_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_679735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079019.1">
        <property type="nucleotide sequence ID" value="XM_018213934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX54"/>
    <dbReference type="FunCoup" id="A0A194XX54">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="28823660"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679735"/>
    <dbReference type="InParanoid" id="A0A194XX54"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="93"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="638" mass="68272" checksum="D3C1CE7EA7DF57FD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX86</accession>
    <name>A0A194XX86_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_679560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_679560"/>
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    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="243" mass="26983" checksum="94B718DDA471A6E4" modified="2016-10-05" version="1">MYLTLISIVKSIFSSSHSKGVVAPASEENEDHVYIKGNPDDRGPCPGLNALANQGYLPRDGKNLTLAQVETALKNGLHMTPLLATSLTNALKPLLRKDKTFDLADTRRHNVIEHDNSFTRHDLWQGDNYTFQPDMLAAILDDADGGPITLKSLAKSFKRRDREQKAIGAPKLPLKLWFVRVLNIAGSINTAALPKGRVPREVFEQLFAEERWAGVILENQKTRSVATLLYNAVVLVWYVVTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1X7</accession>
    <name>A0A132B1X7_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_411607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060737.1">
        <property type="nucleotide sequence ID" value="XM_018207328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1X7"/>
    <dbReference type="GeneID" id="28817054"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_411607"/>
    <dbReference type="InParanoid" id="A0A132B1X7"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="111"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46470" checksum="D9FFEC2CE440901E" modified="2016-05-11" version="1">MTLKLTPSAFIKPSSGIGHNVYKHISQPSYQLRQPAVLPDPGHTLPPAQYPLRHQRSDTKKVLYNRNNLKMLWKVFTSLVLLASRSHASPSFATAPMLRFSCSQLVVERLDPLVNPGVNPSPHLHQIVGGNSFNTTMDPANDMPTLSTCTTCTFSEDFSNYWTAVLYFRARNGTYKRVPQMGNEFLEQQNGGLTVYYIPPYDGHTNVTAFKPGFRMLVGDPMLRTDTNTSEANSMSYRCFEKNWGQIDTYPGGGNDTRDFPSVPCPGGIRVNNFFPTCWDGVNTDSADHKSHMSYPASGSFESGGPCPASHPVKVPQVMFETVWNTTEFNDKALWPEDGSQPFEWSMNDPTGWGHHGDYVFGWKGDALQRAMDNFCHQDCPTLKTQSYDDANKCTKAPVVNEPIDGWLPTLPGIAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B218</accession>
    <name>A0A132B218_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_603393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060785.1">
        <property type="nucleotide sequence ID" value="XM_018210299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B218"/>
    <dbReference type="STRING" id="149040.A0A132B218"/>
    <dbReference type="GeneID" id="28820025"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603393"/>
    <dbReference type="InParanoid" id="A0A132B218"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="88" mass="9989" checksum="10FC38FA3D7EB622" modified="2016-05-11" version="1">MLSVKPHTKTWKELGNYNSCLSGVIWVAQLIIFHTSVCLEKAELGSTLERIEQYCGRFLKQDTETPIGEILGWRLLLFTVSKEVVGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B329</accession>
    <name>A0A132B329_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_632431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061008.1">
        <property type="nucleotide sequence ID" value="XM_018211303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B329"/>
    <dbReference type="GeneID" id="28821029"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632431"/>
    <dbReference type="InParanoid" id="A0A132B329"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="482" mass="52441" checksum="1A2F393136347602" modified="2016-05-11" version="1">MAIFKKQTLKTKNEKTRAAELTLRQSIYPLALVTILFFLWGFSYGLLDTLNKHFQNTLGITRARSSGLQAAYFGAYPLASLGHANWILRHYGYKPVFIWGLCLYGVGALVAWPCILHRSFGGFCAAIFIIGNGLGSLETAANPYITVCGPPRYAEMRINISQAFNGIGTVVAPVLGSYVFFLKTADDTQALKNVQWVYLAIACFVFLLAIVFYFSPIPEITDADMAFQAEETHANDDIKPFRKQYRLFHAAFAQFCYTGSQVAIASYFINYVTETRANTDSSLGAKFLAGAQGAFALGRFTGVGLMKYIRPRWVFLFYLTMCIIFIAPSITQRGNTGMSMLYITLFFESICFPTIVALGMRGLGKYTKRGSGFIIAGVSGGACVPPLLGAAADANNSTAIAMSVPLAFFVAAWSYSLCVNFVPSYRDPADKFLTTKIGIEGAGAGVVEDEESGVGSGPEKAGVVEKENIGEHVDNSPEVKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B392</accession>
    <name>A0A132B392_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_542607</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060864.1">
        <property type="nucleotide sequence ID" value="XM_018208196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B392"/>
    <dbReference type="GeneID" id="28817922"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_542607"/>
    <dbReference type="InParanoid" id="A0A132B392"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="96" mass="10461" checksum="63B3091CF32EFF51" modified="2016-05-11" version="1" fragment="single">RGASYASPRSPQNSGSKIPRRTGSPLGHTRNGGGSMGANTESPAAKEAKRWAALKRKEEREADESIRRLDAQLKAMIREGKEALGTKIEVELDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B436</accession>
    <name>A0A132B436_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_370779</name>
    </gene>
    <organism evidence="5 6">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_370779"/>
    <dbReference type="InParanoid" id="A0A132B436"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
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        </location>
    </feature>
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            <begin position="55"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="471" mass="52612" checksum="50BB49DFFCD8209F" modified="2016-05-11" version="1">MPLAIAAGLGNLAMVELLLACSPEISAENVNGNCFPVIGYPGDAEESPQLYIFPTPLYMACAQGHMDVMQLLVDHGADMSLPSPQDRIGLSRHNGNIVHTLQPPTRPFDGSELYVNDIQPFGGSYDYDSGRSWKTPFDAATFGRTDDTLNIMRAHRATAGHSSVVETLPILSVTNFEIWETILQPKEDVSKTVINLEFLFAAGLDLRATKVEGQSFILWVLDHDVEYIRALNPGRSRLLKTHIPHFVSAILELLAIDNLKIHQYYKLFLTILQVYDVLTLARILSGILKHSNTETAKEFLFNIFLHIIRRMDSSIEALDIVTAIIRATRANQNLVTRGFRVARKPLPASHQEITSRKNTGSKSARGDINVSQRISIDFLRKYFDALCFDRCGATRQALTNIMLIINMIECDLVNFLLLVDNDNELDSSSGFESLETNLETESQFKTHQANEDLLNIQKSHSAAKYHGPCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4P1</accession>
    <name>A0A132B4P1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_364300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061727.1">
        <property type="nucleotide sequence ID" value="XM_018207017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4P1"/>
    <dbReference type="GeneID" id="28816743"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_364300"/>
    <dbReference type="InParanoid" id="A0A132B4P1"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="35895" checksum="F11F22BBA83D167A" modified="2016-05-11" version="1">MSSCGQGTPVLLGIWLVGPAGAVIRTYNQPGRQFGSSGVPKEDKETCFKTYLKTERLIDSARRSGMMKWAQSVTICTVIVLVGWLLWSSKTKPTPELQGQTAARYLHLLIPSNSRNVNLCKTLLSAAALDYPIPTAVNWNQSFDDASLVAGGSHLAKISGILDYLNTLGDERNDDLVLAVDAYDVWFQLRPVVMIHRYYELIRMAKQRIIARLSRAAVEAEKIEQSVIFSTQKRCWPREADDPGCFAIPESTLPKDVYGPETDTDAGTADNPYLKYRPRYLNSGVSMGDVAGMKRLFRHALQRMQQDRNFGSDQNIFAQILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5I3</accession>
    <name>A0A132B5I3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_766367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061604.1">
        <property type="nucleotide sequence ID" value="XM_018221726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5I3"/>
    <dbReference type="STRING" id="149040.A0A132B5I3"/>
    <dbReference type="GeneID" id="28831452"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_766367"/>
    <dbReference type="InParanoid" id="A0A132B5I3"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="265" mass="29900" checksum="95A90D8B31E2A158" modified="2016-05-11" version="1">MSVDGEIEMIYQYYPPGVKKVIASGGSAFIGEVDESTVLKYPLAPGREAIRTEIERKLLEIIGPHPRIIGFKGFSDMRIYLERAVNGTLAHHLLESGLPPPSTRQRLSWCREAAEAVAHIHSRRVLHCVIQPTNLLLDDEFHLKLADFQGRHLSEDGQVLLDGWSGEPCRFFCPRNDFFDANIITDLFALGCNFYFIMMGHAVFPDIKDGEDGFREKVAARFEKQEFPQDFHACSTVTLNCWKGLYGAAGEVVEEIKALEQKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5S7</accession>
    <name>A0A132B5S7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_725519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062120.1">
        <property type="nucleotide sequence ID" value="XM_018218981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5S7"/>
    <dbReference type="GeneID" id="28828707"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725519"/>
    <dbReference type="InParanoid" id="A0A132B5S7"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="401" mass="44501" checksum="A3BB949E56D4E21C" modified="2016-05-11" version="1">MMSARKPHRKSRTGCVPCKKRHVKCGEEKPKCVNCSEYEVDCHYLPVTSVSLKDSLRSRSSSHSSSSLPKDPLGTGNATGIGVSSNPGNDELDVSDLELLHFFSTVTYATMSTVAVEQDLWRTTIVTIGLQHTFLLRALLAQAAAHLSCLKSSSESVNYLIKASTHQNIAIAQFRKALETIDASNFDAVLAFSCLLPVHSLTLAACATARPERNEQDHILSEFLKAIRLLRSVNSLLLPSLSVYTSSPILPLLQVASQHLPVAENYPGQESIGFLDTVCCRNNVAEHNAAFSDTIKELRLTFSRAACPPDTERFTLGIILLFTVIVPEEFVILANSRVPEAMVILAHYATLFCEHDDTWWLRGLGTNMVDIINQELGDEWRHAMEWPNEVAERVRRERDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B629</accession>
    <name>A0A132B629_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_353854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062220.1">
        <property type="nucleotide sequence ID" value="XM_018206950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B629"/>
    <dbReference type="GeneID" id="28816676"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_353854"/>
    <dbReference type="InParanoid" id="A0A132B629"/>
    <dbReference type="OrthoDB" id="5430750at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="219" mass="24655" checksum="446440935664FDD1" modified="2016-05-11" version="1">MKKKQRKNFESRNTTDVVEERSSSLVITGDPSGHLWICSIWSSLTDAEAMSASVKSVLPVLGQFIHQQVCARCLAFLILLGHLCEKLATEYDTILTSLDGIVGLGERVLLEGLEWGTTEAVDKLKKMLWGLEALRVFDDRLSASLAQIQKGRESMERTIKQEAGQQHVDLLEAYNNVIEEFEKRFGMLSDVQIRTQLKIRQVTGLRDGVGVQFLIFFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6M0</accession>
    <name>A0A132B6M0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_691298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062336.1">
        <property type="nucleotide sequence ID" value="XM_018216275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6M0"/>
    <dbReference type="GeneID" id="28826001"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691298"/>
    <dbReference type="InParanoid" id="A0A132B6M0"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="343"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="480" mass="52056" checksum="C8A7D7CAFC7C3B1C" modified="2016-05-11" version="1">MILTNPGGPGDSGVAAALGLGKELSAAFGTSYDFVGFDPRGVGYSLPSGICVGSGASPQKRRSIETIPVGRGPEIPELFLEAAYQNATVNGEICQEQIGGPNDAGPHMTTSVNAKDMISILDAFAASPEAVGVENATDLNYWGFSYGTFLGQTFASMFPDRVGRMVIDAVVDPEDYILMQDEKMIQFSDETFSTFFIYCFLAGDACPYFTGSSPYDVYLRFADTVSKLDVDHAFSHGWQNATDLYLLLEDVKLTLFEGIYSAIENFPTMAQTLVMVEQALKNLTSASLGTFETYVNSYLPIVGQSPAIFCTDGGNLLFNSTLKDMSFITASLKSQTWVSGEILSVTRIDCAGWSIKGTERYAGPFGGDTKNPMLFVSNTRDPVTPVYNGQKWSHRFKGAQLLTVDGTGHTSPITKNTCAFQKIGNYFKTGELPGNDNFCKLEVGPWNVTIPQGMENVNGWRDIQDGLASLRAPAPCRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6S0</accession>
    <name>A0A132B6S0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_691372</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062455.1">
        <property type="nucleotide sequence ID" value="XM_018216303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6S0"/>
    <dbReference type="FunCoup" id="A0A132B6S0">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6S0"/>
    <dbReference type="GeneID" id="28826029"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691372"/>
    <dbReference type="InParanoid" id="A0A132B6S0"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="293"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="594" mass="65944" checksum="43A16C79ABAB334A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAD8</accession>
    <name>A0A132BAD8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_761925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063721.1">
        <property type="nucleotide sequence ID" value="XM_018221558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAD8"/>
    <dbReference type="GeneID" id="28831284"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_761925"/>
    <dbReference type="InParanoid" id="A0A132BAD8"/>
    <dbReference type="OrthoDB" id="3547599at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="346" mass="39848" checksum="E5D36AFFD21EFF40" modified="2016-05-11" version="1">MASDKMAVVRHSTDPSSVSTLRDHVTHGSITPLSGNEDDLLSETATKVLSEDQATWGKEAYDTWGGTIGKKTYDAWNVPMGFPWEALPYELREKMFEDVTSPHFSSWKNLDFQRTHLIVELRELHPLVVAMRGFQLTGMNKLELAGVRKLYLNIGEIETTLPYAQFPQPHWAQLFTGFRKPKWFTDYFLLNVANVQEVTIVSYRYHPSVSFISEFPFWLQGFKNLKLLEVWIPTKTGIISAKRRKGLMRGLKKRVLRKMGVEGVASESEHVGLQPWTWEASEGQSMDWSQEIGWPWNLPYRQTHRNKKRTSKVCYELSMNGGGFILKSVESDESHEHSNCPFPYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAS8</accession>
    <name>A0A132BAS8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_657928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063875.1">
        <property type="nucleotide sequence ID" value="XM_018212452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAS8"/>
    <dbReference type="GeneID" id="28822178"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657928"/>
    <dbReference type="InParanoid" id="A0A132BAS8"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="769" mass="88397" checksum="89997229C7C2B81F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBA9</accession>
    <name>A0A132BBA9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_597543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064026.1">
        <property type="nucleotide sequence ID" value="XM_018209982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBA9"/>
    <dbReference type="GeneID" id="28819708"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597543"/>
    <dbReference type="InParanoid" id="A0A132BBA9"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29908" checksum="92871B9A32B6879D" modified="2016-05-11" version="1" fragment="single">NMQLLAQKGIALTNYFSTTHPSGLNYCAIHGGDNFGMDNDNCNQIPANVSTLFDLLAEKDSSFGEYQEDVPYTGFEGYQYLDPEAGANYYVRTHKHNIDFSSPAVLYNKNVEESTKLNTIKRFVEFYDDMDSNEMPQYMFITPNMLNDAHDTGIVYGADWLYQFLESILENKNFMNTLLIIKTYPIENRFMPVLLLDNLPAELVNTTDDTFYTHYSILATTEANWDLHHLGRWDTHANVLKFVANATGDMIRAPDVNLDNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC77</accession>
    <name>A0A132BC77_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_268400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064385.1">
        <property type="nucleotide sequence ID" value="XM_018206339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC77"/>
    <dbReference type="GeneID" id="28816065"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_268400"/>
    <dbReference type="InParanoid" id="A0A132BC77"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="23059" checksum="E5DCB243D59FCD76" modified="2016-05-11" version="1">MVDIVFLDLPGEIRNQIYNHLLIVPAISKPRLLGDPPMYPQILSTCHKIHEEGKQILYGGNTFLAHPNLLSDRPRLRLYYDAISSSSLISLICKYHIRVRLDCDPNFSVHKAIAAFTGVEELTLEVFQAQFGSSDNKVLRLFEGIRGVKKARIYGSVTDFPEYVRWLQNSMMLPVGVEVEPFDKEKIGLNQVSGYDIWTHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCH8</accession>
    <name>A0A132BCH8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_710873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064436.1">
        <property type="nucleotide sequence ID" value="XM_018217868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCH8"/>
    <dbReference type="FunCoup" id="A0A132BCH8">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="28827594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710873"/>
    <dbReference type="InParanoid" id="A0A132BCH8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ10081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="539" mass="57563" checksum="93757C6C8A860210" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD24</accession>
    <name>A0A132BD24_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_701089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064508.1">
        <property type="nucleotide sequence ID" value="XM_018217168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD24"/>
    <dbReference type="STRING" id="149040.A0A132BD24"/>
    <dbReference type="GeneID" id="28826894"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701089"/>
    <dbReference type="InParanoid" id="A0A132BD24"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33354" checksum="D3648122A76F290E" modified="2016-05-11" version="1">MLGHRSMEVDLVRLQKSEAIQLIKTTLMGWENPQGDEHFKKQRKQADSGKSAALFYRMMKEIGVELHLKTNALTLTNVSPSEVKILTEASGITLSPDQGGHKVFLNSPLSTVLYCDITMFATEFGAEYVPVTHPEHATFSTERPFLSQTFNLIFCHGQVLRTHPRMEYREAYEATRLTFPQLTLAMQCISEGGTFIMLLHKVEAWDTMDLLYRFLQFSDIELFKPIKKHAIRSTFYLVAKQVRPSSEAARLAVQHWKEGWWQATFVRSKLAGLGRKVLTIQADALKKADFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDF8</accession>
    <name>A0A132BDF8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_760834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064374.1">
        <property type="nucleotide sequence ID" value="XM_018221520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDF8"/>
    <dbReference type="GeneID" id="28831246"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760834"/>
    <dbReference type="InParanoid" id="A0A132BDF8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="389" mass="45312" checksum="F2BC3F382BC9ABC9" modified="2016-05-11" version="1">MCTGPNHECRRCGNFEGPDSVEFESRCDNPWAYGHTITVVSAVIVTSACGACKRLARDEADELDEMLRQQNSPTRQLHEQNPQAPQNQEFPLFFILWCELNSNGELAENELSAEEALNADIASFLGYLRDAHFDPAHVHLAHLYGGHIEWLRLDKRTNFDFEPLMQPALPRFQIWARSQATRDHVQQDNHTIAASDAHRRFQRMVVTYAEMLDPRDRAEFQASRERQAVNGRREQNYEERQDHEYNVLPWRAWIPILTPDVPAPAEQEDEPIESFSHWVSRRDYLPPHVQRYPTHPGAVAWHESIILMHGAADRHFNFVPNFYVARPEILSFMQFRARDAPAGSVYALPFDEALREYERYLSHELPGPRMNQRWLDAVDEWMFQARAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDM0</accession>
    <name>A0A132BDM0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_675304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064833.1">
        <property type="nucleotide sequence ID" value="XM_018213498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDM0"/>
    <dbReference type="GeneID" id="28823224"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675304"/>
    <dbReference type="InParanoid" id="A0A132BDM0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="22849" checksum="912EB339D5D78B4D" modified="2016-05-11" version="1">MTLGDILKADPGRRIFASLYLGLQQQSAIPFARCRDKYNLEQYKEKMPCTVPLYDRLVGEQANFDEIARIAKGIAETHSEFELRFGTPFIYPNLAAELRAGRGDRRVIYSLLSSGYDAVRKDLNRELGDVLVYRNSSFRQNKDYRQLPQIHRIRDDNRTKNVSARMNVARRLDKYKANICFGGSQKKQCEQGPWCSGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDW3</accession>
    <name>A0A132BDW3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_596536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064923.1">
        <property type="nucleotide sequence ID" value="XM_018209928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDW3"/>
    <dbReference type="STRING" id="149040.A0A132BDW3"/>
    <dbReference type="ESTHER" id="9helo-a0a132bdw3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28819654"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596536"/>
    <dbReference type="InParanoid" id="A0A132BDW3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007230012" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="40"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="528" mass="56407" checksum="370C883FB7E4EC2B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRG8</accession>
    <name>A0A194WRG8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_626039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064963.1">
        <property type="nucleotide sequence ID" value="XM_018211090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRG8"/>
    <dbReference type="FunCoup" id="A0A194WRG8">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRG8"/>
    <dbReference type="GeneID" id="28820816"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626039"/>
    <dbReference type="InParanoid" id="A0A194WRG8"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="496" mass="57018" checksum="A0DBD724E517B795" modified="2016-10-05" version="1">MEEFEYTLENSQQFWDELEDIVSANCPSHQLIDNALRSYLYFTTRFKDEYLASDYDFAQCLRKLFQSSLFDKNKEYVRTQIVYSLLQEDEPASLHVIASFLLFDGRQNEATFEMMNNEGCFPRLVDLIKKGKRDDARLHRMLLELLYEMSRVQKISSEDLGVVDDDFCQYLFQIIEELSDDVDDPYHYPVIRVLLVLNEQWMVASTRSPVESHPPSTPLTNRVIKLLSLHGSSCMTFGENIILLLNRETETSLQLLILKLLYLLFTTKATYEYFYTNDLHVLLDVIIRNLLDLPNELISLRHTYLRVLYPLLAHTQLNQPPHYKQDEIIKVLSILGGSANTHWEPADETTVRLVERVAKVPWLRDEDVSEGEVARKLLGISLSPTQTASMVSVVDVAAVMEKPGVKTPSRKTEFEEEIHNFDGAADRKESHELEVHMPVKKKPPPPARRTKHAPPPIPPVLQVNGGKIPPKAPPRRRTRLKPMASTGDLESKARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRK3</accession>
    <name>A0A194WRK3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_596020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064988.1">
        <property type="nucleotide sequence ID" value="XM_018209892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRK3"/>
    <dbReference type="GeneID" id="28819618"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596020"/>
    <dbReference type="InParanoid" id="A0A194WRK3"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53001" checksum="155AB36E5868CD2E" modified="2016-10-05" version="1">MADNRGGGSRSPRKVPAATKKVGPPRQRMSSLMYSLPVRRLKDILSHVLPDVTLSSTEELKSSGLARLFTLKMSDGEKVLLSVAPSLSIRLLRQESTILSTEAVLLNFLAESDLDGKSGKEKVEEGEDEEEDESSKAKDDSQKVSRALLGLAPKLLKHAKDSRELAYPYTIVSSTPGEPLTKLAPFLSVPERHDIDKQVGALARTLANLTSPMKLFGMANKALPFPCQPSGPSAPPKLGCKTWAEGFNTLLESILRDGEDMAVLLPYEVIRSHFARLSWRLDAVTTPRLAILDINDPKNVMIERDPDDEETMLPSEHIRLTGLRNWSQGVFGDPLIASCFDEPTEGFQEGWDAAGEEIIEDGEHSETRKLLYRCYRAIVEVVTEYYRPKGDSSRRELGGRRKLTQVLAQLEKVDVVDGDAPKRVRSSSTDGESSKRVKTESKGKTEPTGRTEPRGTTELKGKTEPKGRRYQKTNDGMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSN3</accession>
    <name>A0A194WSN3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_689342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065049.1">
        <property type="nucleotide sequence ID" value="XM_018215891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSN3"/>
    <dbReference type="STRING" id="149040.A0A194WSN3"/>
    <dbReference type="GeneID" id="28825617"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689342"/>
    <dbReference type="InParanoid" id="A0A194WSN3"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="144" mass="15177" checksum="E2B36ED9D6AD29A9" modified="2016-10-05" version="1">MATNGASQGLPPEAIAFATRMYDAARSGQVDIFEQALPRGLPANMTNEKGDSLIMLAAYHGHAPLVKLLLDHGADPNRVNDRSQSPLAGAVFKGEDAVVETLLEGGADPDHGQPSALEAVVLFKQEDKWKAKFESAPGRGKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSS7</accession>
    <name>A0A194WSS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate decarboxylase-like protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_723325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065089.1">
        <property type="nucleotide sequence ID" value="XM_018218804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSS7"/>
    <dbReference type="STRING" id="149040.A0A194WSS7"/>
    <dbReference type="GeneID" id="28828530"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723325"/>
    <dbReference type="InParanoid" id="A0A194WSS7"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="526" mass="57173" checksum="BB0A472CC22CDBFD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT04</accession>
    <name>A0A194WT04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_700692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065159.1">
        <property type="nucleotide sequence ID" value="XM_018217140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT04"/>
    <dbReference type="GeneID" id="28826866"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700692"/>
    <dbReference type="InParanoid" id="A0A194WT04"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="8"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="530" mass="58185" checksum="C9BE9414090BD4FC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTK9</accession>
    <name>A0A194WTK9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_242156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065653.1">
        <property type="nucleotide sequence ID" value="XM_018206116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTK9"/>
    <dbReference type="GeneID" id="28815842"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_242156"/>
    <dbReference type="InParanoid" id="A0A194WTK9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="29258" checksum="9EFD9B4C602938A0" modified="2016-10-05" version="1">MDKSSREGTKFLYRRESLRQASISNTYLNENPSSALPGFYTQASKIDKIKIRLPRAFTSLHASPTETIETTTIMYNESATVPVATTAAMRSLDIKILFGLLIALIVILAIAYLCCIRALPQDYSEIYKEDLLFSTPRYINAHLKWLTDAVALLPTTMNHEEVHKRYIGVEKRLKRYCKWQVKKKAMKKAMALVWDEAGMVAQRREFLMRLDMVLRMRKEALVVMENGGAAVDLSLERKRVDAAARVFSAERWGAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTR2</accession>
    <name>A0A194WTR2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_759284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065703.1">
        <property type="nucleotide sequence ID" value="XM_018221460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTR2"/>
    <dbReference type="GeneID" id="28831186"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_759284"/>
    <dbReference type="InParanoid" id="A0A194WTR2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="189" mass="20986" checksum="F208C6898B63C9EB" modified="2016-10-05" version="1">MIRSLSTYTFHSNYSNISQSAAEVSTSKMTNILSNFEGSDQDQNIGIEKVDQTLITRVEAWLNSISEGAPDTTSSTATESQQKEFSNTLSEDDTHQFDFKPYSSVPSIDIWDWVKQPPSPEKWCESVGDADDESSLDDADSTPESDWETSSLVGSCKESASDGDSRSKYPENCEMKLPLTKRLRSPNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUP3</accession>
    <name>A0A194WUP3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_710411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065744.1">
        <property type="nucleotide sequence ID" value="XM_018217826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUP3"/>
    <dbReference type="STRING" id="149040.A0A194WUP3"/>
    <dbReference type="GeneID" id="28827552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710411"/>
    <dbReference type="InParanoid" id="A0A194WUP3"/>
    <dbReference type="OrthoDB" id="3438962at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="14817" checksum="11F40DEF193E4DBA" modified="2016-10-05" version="1">MDSSHQSSLNSARGAGTTFGPDDTNPSSTATPATSVGSATAAGHGDHPQDNADDSNATLPGSKVGPQDEDLEGEQMRAAGEGDVMDAQFNKKDAGWGEQGSLTSDLDRQKAEQKSAREGVQAARQGGENVDGGAGNRVENEGMGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV47</accession>
    <name>A0A194WV47_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">laccase</fullName>
            <ecNumber evidence="6">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_688346</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066198.1">
        <property type="nucleotide sequence ID" value="XM_018215689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV47"/>
    <dbReference type="SMR" id="A0A194WV47"/>
    <dbReference type="GeneID" id="28825415"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688346"/>
    <dbReference type="InParanoid" id="A0A194WV47"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="84"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="293"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="449" mass="49784" checksum="47D12F59D4C31DB2" modified="2016-10-05" version="1">MENNGSSIHFHGIRQNYTNPNDGVSSITQCPTAPGESTTYTWRATQYGTTWYHSHFALQAWNGILGGIIINGPSTANYDNDMGVMFLNDWTHQTVDQVYITAETSGPPTLDNGLINGTNVYGDLGSRFNMTFTAGESYRIRLINGAVDTHWKFMIDSHNLTVMAMDLVPIEPYETNVLSIGMGQRYDIVVNASQTSGNFWIRAIPQTSCSDNDNADNIKGILKYDSTDTTEPTSSAYSYIDSCDDEDMSDLVPYLALDASADTEEDDFAVTVGKVNNLFKWYMAATTFVAEWDDPTLLQIYNNDTNFTTSSHVIEVDTADEWVYFVIETTQTVPHPIHLHGHDFYVLGQGTGTYDADTTTLTTTNPPRRDVAMLPSSGYLVIAFLTDNPGAWLLHCHIGWHTSEGFALQIVERYSEIAALIDYDTMNSTCAAWDTYVAADDIVEDDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVD8</accession>
    <name>A0A194WVD8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_653469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066288.1">
        <property type="nucleotide sequence ID" value="XM_018212253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVD8"/>
    <dbReference type="STRING" id="149040.A0A194WVD8"/>
    <dbReference type="GeneID" id="28821979"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653469"/>
    <dbReference type="InParanoid" id="A0A194WVD8"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="238"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="499" mass="54799" checksum="C4F4CCEBE1D21215" modified="2016-10-05" version="1">MDDLLSKLLMFPPHPPPAKPLSDHAYDEGIKEQIEVVGKMSETKLLQQTSGGEHALDVINPSLNTIPYACILLANISALKKGNNKGVEIDTLWEKMIGFLSAFDSRQIRYIGDELSAIIEAVAATAFSTRQAHLAVGPIASALMRLDPTGTMLTTHHLDLARLALDSRNFADAAPVLNKSILYVPGASTITKPRYICDMTLSPVSFITLQSKLTKKLKYLEILEYFLYSGMVFIGMRDWESALQCLENAVTYPAKETSVSKVMVEAYKKWILVGVLLEGRLLPLPKSTSSGAAKCYHVMAKPYETMAQIFENGTASRLKAEADTATNIWRADFNTGLILHLLAAFQKFQIRSLAKVYTKITIPEIVSQTTSAETGTKLPNPQAAELLIQNMIATGELHATMSPPTGGPSILTFSPTGQALTEPQMQRELVLTSERIVSLTKEIKQTDRILTHDKGYIKYVQKQSKNAKTSGATGDQGISGPDMDWNDALEDEDIMGPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW19</accession>
    <name>A0A194WW19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_709993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066520.1">
        <property type="nucleotide sequence ID" value="XM_018217796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW19"/>
    <dbReference type="STRING" id="149040.A0A194WW19"/>
    <dbReference type="GeneID" id="28827522"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709993"/>
    <dbReference type="InParanoid" id="A0A194WW19"/>
    <dbReference type="OrthoDB" id="3515453at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="17422" checksum="6194186B68094722" modified="2016-10-05" version="1">MAPLVVAQTPYYADQSAPFNLVLHSASTSLDGAALFSCHEGAAIEGLCVTTDFNPVEPVSPYNFNYSSLSTPDPVLGYQGLLTWELQAGSFNLSSPMALQNISDTNVENAFFEPSTTGTLVGFDQSNLLYILDDTTTEPGYSWYGEPDNASCVGVDVERVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXA1</accession>
    <name>A0A194WXA1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_593023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066963.1">
        <property type="nucleotide sequence ID" value="XM_018209727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXA1"/>
    <dbReference type="STRING" id="149040.A0A194WXA1"/>
    <dbReference type="GeneID" id="28819453"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_593023"/>
    <dbReference type="InParanoid" id="A0A194WXA1"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="29769" checksum="C9CFACF0AF6A2BC9" modified="2016-10-05" version="1">MSFATLAAVVAAQKCPLQFDGRIPKDATLDSFDTSSSPFNDAYVIGGNQKWSSILQFPTVNSSLFDANGTKALEVTISSSSIFQSQTGFRRSELLPASNSGTDPSTAGVKTIHFSVQKDTSRPLNTSHEYQLFFLESNDYSTNQVVLKYGSIIGGNPSGVSSDSLMVMGNVNAKPVVNLYSTKFTPGTWHNFAITLNFNAGTTQVYYSTNNAPLASVSKAVKNDVSGQGEYHFGILKKPTGGGSDITKSGFQEAGINEGIIFGGIFEEDSSSSGCISLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY10</accession>
    <name>A0A194WY10_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_699743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066842.1">
        <property type="nucleotide sequence ID" value="XM_018217078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY10"/>
    <dbReference type="GeneID" id="28826804"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699743"/>
    <dbReference type="InParanoid" id="A0A194WY10"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="33662" checksum="3F6EED3A355A5FBA" modified="2016-10-05" version="1">MTQEFLRNQTNLDIPLIKEMRELSAPTDKIDLTLMSRAQGVGLNTIWNDISLEQMANYKDQLGNAIKLWRQFTSPVAKKVNDDPLDDCIIGNCLRRTAPTCKRMGATTDEWFENLEEDLRFGLSLLHKTKDPLVIEDKYQELKRNFPKSDPYVLTHGDLNLTNIIVKDDKIEAIIDWEYSGYLPWWAERWLSLIGGDNQSDELFDPLWADIGLEMDEATFQTEVIDKVAPVIQAWEEGRFHVEHPDSHIAWVRPGFCKCKPWAGTINWTELGNQPEHKLRDDIVVKKLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY75</accession>
    <name>A0A194WY75_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_687845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067276.1">
        <property type="nucleotide sequence ID" value="XM_018215588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY75"/>
    <dbReference type="STRING" id="149040.A0A194WY75"/>
    <dbReference type="GeneID" id="28825314"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687845"/>
    <dbReference type="InParanoid" id="A0A194WY75"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF43">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="142" mass="15898" checksum="A5A23A9DD4538C7B" modified="2016-10-05" version="1">MEGTCLCGAITVRVKDDELFSRRRGHICRCTNCKKTAGCAMATNLTIENEKIEIVGEENLKKFIDTKTLSGTPLARYFCSTCGNPIKSVTPLYEGKTVLKTGIFPQIPTPEWESFSLNRQKWELPLDGAVQYKTKSLGEKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYC5</accession>
    <name>A0A194WYC5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor PAP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_687858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067295.1">
        <property type="nucleotide sequence ID" value="XM_018215590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYC5"/>
    <dbReference type="GeneID" id="28825316"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687858"/>
    <dbReference type="InParanoid" id="A0A194WYC5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor PAP1" evidence="2">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="168" mass="18626" checksum="064068BAD34983EF" modified="2016-10-05" version="1">MAPAPQNLLEAGDGAAASRPPHDMLNSPIDWDEMPDFGTEPARAAPPTSNSQVFSGNITQPRDSLQVLKGKVIFGRNFYSFNQAETPEWKRVTGARTRCKACDPIVPHFKNKRWVFYPSNSDVRIVVSCSWSSCERLRPKVKDGEFGLDRACKDLQEKAKCSETGAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYZ3</accession>
    <name>A0A194WYZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_153842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067536.1">
        <property type="nucleotide sequence ID" value="XM_018205435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYZ3"/>
    <dbReference type="FunCoup" id="A0A194WYZ3">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WYZ3"/>
    <dbReference type="GeneID" id="28815161"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_153842"/>
    <dbReference type="InParanoid" id="A0A194WYZ3"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="237" mass="25312" checksum="6E154385D2FEEF11" modified="2016-10-05" version="1">MADIRAPPTPMAMLIGTAIIAAVSGYMIGIASSLGFIPIPFMSKAVTARGVSNYDDEEESEEEDIDESILDHAPNWANGFEADKRDGLRATAAATKKGKENNQLVVKPSQETAVVDSGEPCKMVLIVRTDLGMTKGKIGAQCGHATLACYKHFLKNDPKSTILRRWEREGQMKVALQVKTEDELDMLQAQAISLGLVAEVIADAGRTQIAAGSHTVLGIGPGPVSLIDQVTGQLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZW2</accession>
    <name>A0A194WZW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_591436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067841.1">
        <property type="nucleotide sequence ID" value="XM_018209654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZW2"/>
    <dbReference type="GeneID" id="28819380"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591436"/>
    <dbReference type="InParanoid" id="A0A194WZW2"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="39802" checksum="84228E1578F37F88" modified="2016-10-05" version="1">MPPSLPIIICGAGISGLVLGQGLKKANIPFKVFERDPALNVRSQGYRVRISSIGISALKETLPDDLFSQLRACTAVAASTPDEPFRRIDALTGEKPKPYYPATQDAEPPLNADRTVLRRVLVKAIEQFVSYGKEFLRCEVLSDDTVKVHFSDGTEVLGSLLVGADGTKSRVRKQLLSNNEFIDTEGRWFYGETELSTKVEERFNKHADHYSIIQNTSKGRVLTCLLEPVRFKENEFRKELPADYIYWVLGGCKDIFDMDDEVLLRLSPEEAATETMRMTKNWDPSFHILFSAQSTGQTSILALESSKPDIEVWETQKSVTLLGDSIHAMSPTAGVGSVTALRSAAALTKAVVEGGVMLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0F1</accession>
    <name>A0A194X0F1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_145329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068031.1">
        <property type="nucleotide sequence ID" value="XM_018205346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0F1"/>
    <dbReference type="GeneID" id="28815072"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_145329"/>
    <dbReference type="InParanoid" id="A0A194X0F1"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="44062" checksum="441A3954C9468D0E" modified="2016-10-05" version="1">MQNEIKQSAEICDEIATFQLQRIMSAKGLREEISHAHIAIEDIEEGQKQATAVNEAQIIREGGMLPAKSHAEHWEAETHADDNVPNNVDLDCAVEELRNQIDGLRARFNFECTLHGMMQKLKLEFAINANLDGAELDKFVSSTDDDQEMRLGRSSLPNAMPMMNDFVKGALNPKLKDLGMAILSTHLKEDKPYTLEYLARCGSPKAWNSEELNDIFNTPETESAPPTPVNEDWAEPPIPCFTCGQTGHAAKDCRVVDFPAETEAQYLEAPESKANNEMPSTKLWVEKDVYCDNCGMYGHSEDYCNHIFPEEEKPNYCNQCKKHGHMEDTCWRLHPWLKEQFLKEQFLKEQFLKEKEEKEKKTRCLDCGRVGHERRFCYKVHQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1S5</accession>
    <name>A0A194X1S5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_720520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068505.1">
        <property type="nucleotide sequence ID" value="XM_018218576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1S5"/>
    <dbReference type="GeneID" id="28828302"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720520"/>
    <dbReference type="InParanoid" id="A0A194X1S5"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="560" mass="61524" checksum="C5CC869DC3758807" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2X3</accession>
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        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_589799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
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        <property type="protein sequence ID" value="KUJ14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209559.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28819285"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589799"/>
    <dbReference type="InParanoid" id="A0A194X2X3"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="587" mass="65288" checksum="B678D3CBF3138610" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2Z2</accession>
    <name>A0A194X2Z2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_784480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068910.1">
        <property type="nucleotide sequence ID" value="XM_018222792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2Z2"/>
    <dbReference type="GeneID" id="28832518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784480"/>
    <dbReference type="InParanoid" id="A0A194X2Z2"/>
    <dbReference type="OrthoDB" id="3799527at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14555.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="514" mass="57530" checksum="6CAFBB60BCF802AE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="21070" checksum="790132B243090757" modified="2016-10-05" version="1">MPSSQHALHLDSNSVSNLSSYQVLQHQPSSPPTTNHHHRHPTTMSSHHSSKAKSGSRRSSNLGLGGSDFPRFLLPPSNETLWEHMRRRHPNIPSGSVYNGTCPDPKRHGPTCPCYVFIVNKNQRPQFFWHRLDMQEKRLAVLKSFAASDKNTKPEMIEKEIARVEELCMDLRAVVMEELKKKGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4R0</accession>
    <name>A0A194X4R0_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_670664</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ15160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13410" checksum="FE0C77E8E4053B2D" modified="2016-10-05" version="1">MSFTVLYACVGVGTVAVVLFVVLSLTAPLVLEIGYGIIGGLLVLGGIGWILYRNSDSIGDWWQAFRDRRQAERDARRVRRETLRQEEETRRAVELEERRVRAGVIAVEAISSGEAMNGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5P9</accession>
    <name>A0A194X5P9_MOLSC</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="PANTHER" id="PTHR43130">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="253" mass="27223" checksum="32E6ACDB1C23B059" modified="2016-10-05" version="1">MLSQTLSNIIIGLYLLANQVNATPTHFGYLLYQGFEVLDVFGPLEALNGLAGLYDLNLTIVAETMDPISSLPPTSWFNGNKMNSTFSEHVLPTHTFETAPPLDVLIIPGGNGLFAPAPLLDSTIQFIKARYPTLQYLITVCNGAGIAARAGVLDGKHATTNKAVWDQTIALGPKVKWVAQARWVTDGNVWTSSGVSAGIDVMLAWISAVYSEANATGIANGMEYERHMNSTDDPFATLHGLTDANNSTNPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5Z7</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069960.1">
        <property type="nucleotide sequence ID" value="XM_018223494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5Z7"/>
    <dbReference type="GeneID" id="28833220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_89314"/>
    <dbReference type="InParanoid" id="A0A194X5Z7"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="165"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33088" checksum="3F4421141878C600" modified="2016-10-05" version="1">MSFFFHLPPYHPLPGNMQQVVRMIGSLVAAGLFPAVMAAPAPQMNYGENTGAVGGVDPPSPTVTTTSGSLYGPSDLLGEIAKPSPISGGDSAFVSDAPLVNGQEADSDLGLYLDFNSVENPQPLRGTGGQTDPGPRTYEYEKLNPDIFAPPGTDSGDVPQAQWPLGLSHNRFGTGKQSGWARQQNTDQLPAATEMAGVDMRLAPHAYRELHWHSANEWSLMLKGSVRLSAVNENGETFIDDISAGDVWFFPAGVPHSIVRYTLVSYSPGELSVQKSSQEPPIKEYLVDLFRRAGVRSLCQESILKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6Q9</accession>
    <name>A0A194X6Q9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_586981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_586981"/>
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    <dbReference type="OrthoDB" id="10251809at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="558"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="558" mass="61136" checksum="F44EA72BB1150402" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A194X6V3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_719586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28828229"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719586"/>
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    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="116"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="687"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="769"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="865" mass="97249" checksum="A1D17C39F317E4AD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X780</accession>
    <name>A0A194X780_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_735172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219983.1"/>
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    <dbReference type="GeneID" id="28829709"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735172"/>
    <dbReference type="InParanoid" id="A0A194X780"/>
    <dbReference type="OrthoDB" id="3565456at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="939" mass="105585" checksum="566ED8E0D89078F5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7A6</accession>
    <name>A0A194X7A6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_101959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070406.1">
        <property type="nucleotide sequence ID" value="XM_018205012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7A6"/>
    <dbReference type="GeneID" id="28814738"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_101959"/>
    <dbReference type="InParanoid" id="A0A194X7A6"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443874" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="560" mass="61521" checksum="4BBB914777FF5B6B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7K8</accession>
    <name>A0A194X7K8_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_670331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7K8"/>
    <dbReference type="GeneID" id="28822878"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670331"/>
    <dbReference type="InParanoid" id="A0A194X7K8"/>
    <dbReference type="OrthoDB" id="3561422at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="52302" checksum="0BB8F3A95546FA58" modified="2016-10-05" version="1">MHEALFLMLNQDAARCQRVCHDGFTQPSFVRNPTCAPVIIGDPSAENARVQPYICLKCRTLTTSPVNNIFILKRLSLRPRELKSKALQRPNHTAVSSLRLCIDEQQQQFSSIIYVCIVEIEQVAGLIISRQRPTVALCDVASRTSWVSSQFVDELETISRAGIGLANSTSFRKEGEPPRIHIRWSCGLLGQAHEEGTFFIEPKARFKILFGCAYSTNHLPTKHFRSRRSTRTKGKRIEPQPHIRDQAVESFRAGVETGILVPLERMNLKQDNRPTLMPIADVEVDLDYTWQLYSGTDQALNDGPNQSDSSNFMPSFYGNVFSPKDITSANSSVNTDERDHMLESTDASFSESSYQSTDWIGGPSGAQHHTEPGYMIGSWANQSVYEEPQYWAVPRMMYSEPRPWSIQRCRDLTPEHRTKLAAAQESAGKEAEKYWQWDEEEKKYKHYDEGCADPVWYNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7L7</accession>
    <name>A0A194X7L7_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_697437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070520.1">
        <property type="nucleotide sequence ID" value="XM_018216903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7L7"/>
    <dbReference type="FunCoup" id="A0A194X7L7">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7L7"/>
    <dbReference type="GeneID" id="28826629"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697437"/>
    <dbReference type="InParanoid" id="A0A194X7L7"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="248"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="402" mass="44598" checksum="71F9326FD125391A" modified="2016-10-05" version="1">MPLPRASLRSFLSSAKSALNNAAQQSSPVTFVIGNESADLDSLCSAVVLAYIRTYSLKSKTFYIPLSNIPRADLNLRPELLSVLSHANLRPSDLITLSDLPSITSNSSRLSPEKTKWVLVDHNVMVGELGKIYGDQLVACIDHHDEENKVPKDTAEEPRIVQKCGSCSSLVVQYGREAWDSLASKTSQDHQAKWNAELARLALAPILIDTSNLKDESKTTPVDVEVVKYLQHWITSEEEGPFDAEDYFKEIADAEKDVDSMSLVDLLRKDYKEWNDGGVPLGICSVVKDMPFLVKKAGGTEQFLSAVKDFAKERKLSVCSVMTRTLNNGVFSRELLVWGFGQKGIESAKSFEQDAKPKLDLQTWKDGSLDLDNNQWCRCWSQGKAQDSRKQVAPLLRTAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8D6</accession>
    <name>A0A194X8D6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_782644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070734.1">
        <property type="nucleotide sequence ID" value="XM_018222602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8D6"/>
    <dbReference type="STRING" id="149040.A0A194X8D6"/>
    <dbReference type="GeneID" id="28832328"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782644"/>
    <dbReference type="InParanoid" id="A0A194X8D6"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="39433" checksum="777B4D17560FA743" modified="2016-10-05" version="1">MSTPGGPMQPSHGPYLPTTAGLGGMPTKGLDVPITSVFLVLFVLGAVTHMTILQINLRRGHKFIMSGLLFGFCMARIMTCTMRLVWSTYLTNISVAIAAQIFVAAGVLILFIVNLIFTQRIIRATHPHLGWAKTFSWAFKIYYACIIGLLIALITCTVDSFYTLNKSSRRADRDVQLLGSTFFAVAAFLPIPLVLGSIIIPKKTRVEKFGSGRFRTKIYVLLFSSFILSLGAFFRAGTAYVPRPRNDPAWYDSKACFYLFNFTIEIIVVALYAVIRVDKRFHVPDKSHGPGDYSRTAPAQEAGEQEPEMEKRSSLADRVLSEEQVFDDDEETQVGSPAERQTDVEVGLTKPEPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8Y5</accession>
    <name>A0A194X8Y5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_586358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070986.1">
        <property type="nucleotide sequence ID" value="XM_018209362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8Y5"/>
    <dbReference type="GeneID" id="28819088"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586358"/>
    <dbReference type="InParanoid" id="A0A194X8Y5"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="28503" checksum="0815790F79726DBA" modified="2016-10-05" version="1">MCIKYGPAVQLSEAAALRFVAEMTSVPVPKVYSAFQKDRSSYIIMDFIDGEVIGEGWDKRSEAEKASLFAQLKDMFEELHNIPHPRPGVLASSDMQSLYDKRLWKGSHGFGPFANESDFHMFLRCGVHIEDDMIKKETCTWVTDEQKEEMRQMVICFTHGDASSSNVMVKDGKVVALIDFELSGFYPEYWEYTTAMNVNRFDGFWKEEVPKFLKQYPEELQMEELRRKHFGPGGFQGRYPWDILGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9D4</accession>
    <name>A0A194X9D4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_548638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071133.1">
        <property type="nucleotide sequence ID" value="XM_018208275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9D4"/>
    <dbReference type="GeneID" id="28818001"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_548638"/>
    <dbReference type="InParanoid" id="A0A194X9D4"/>
    <dbReference type="OrthoDB" id="3508416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="85" mass="10097" checksum="52F7957DC538CED9" modified="2016-10-05" version="1" fragment="single">SRVLFVEGPEQMMTVDFWFQYFRQVSVFQWDRVLEHPPVRPGRKCLEFRFARINGQAQTCLQQIQRQEEFVGLVGAWYGLDPCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9G0</accession>
    <name>A0A194X9G0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_684819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071114.1">
        <property type="nucleotide sequence ID" value="XM_018214960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9G0"/>
    <dbReference type="STRING" id="149040.A0A194X9G0"/>
    <dbReference type="GeneID" id="28824686"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684819"/>
    <dbReference type="InParanoid" id="A0A194X9G0"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="348" mass="38633" checksum="018A845DB8D90ACE" modified="2016-10-05" version="1">MSSAKQTVLAIGGTGAQGISVVKGLARDSKYNVRVLTRSTKSKPALELAALPGVTIVSGDGYNEAGLHSAFSSGIDIAFVNTNGFAIGEKAEIYWGIRIFEIAAEHGVKHFIWANLESSYKVSGYQPRFRTGHFDGKHKVADWISAQPKDGLMKWSILTSCMYLEMFSELLRPFPETINGEEVMVFKAPVGDGRPPMIFLEDLGRYGRWLIDNPEKSSGMNLKISTDQVGWEEVAQAFTEVTGKKAVFRDVTLDEYFASGAFPDPDAKVGHSVGHDDDTLQTYRENFSGFWNTWKENVLQRDDEVLDEILPTRVKSIKEWMQITGYTGKPGSVLKDYSDARRAPKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9N0</accession>
    <name>A0A194X9N0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070832.1">
        <property type="nucleotide sequence ID" value="XM_018215083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9N0"/>
    <dbReference type="STRING" id="149040.A0A194X9N0"/>
    <dbReference type="GeneID" id="28824809"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685436"/>
    <dbReference type="InParanoid" id="A0A194X9N0"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="207" mass="23014" checksum="9FECB14542253115" modified="2016-10-05" version="1">MAGTKAYPPGGTFLDTVKTSFTDVPVDKEKDYAISTTEFLQAAESLTTLFDVLGSMAFQPVKNDMLGNVKKIRDRQHAAPAESANLQDLVLNELKTKKHTATEGLVWLVRGLDFTAIALSQNLATASEELSVSFRNAYGNTLKPHHSFMVKPIFSAAMSACPYRKDFYVKLGDDQEKVEQELRVWLAALVKLLAILKGFLDRKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAD0</accession>
    <name>A0A194XAD0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_718796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071480.1">
        <property type="nucleotide sequence ID" value="XM_018218446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAD0"/>
    <dbReference type="GeneID" id="28828172"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718796"/>
    <dbReference type="InParanoid" id="A0A194XAD0"/>
    <dbReference type="OrthoDB" id="3564743at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="561" mass="63724" checksum="89D54B7515300DF2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBS3</accession>
    <name>A0A194XBS3_MOLSC</name>
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    </gene>
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        <lineage>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
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    <dbReference type="KEGG" id="psco:LY89DRAFT_684616"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
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            <begin position="1"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="648" mass="71808" checksum="9CEDBC9B86393537" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBT1</accession>
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        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_645207</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071976.1">
        <property type="nucleotide sequence ID" value="XM_018211871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBT1"/>
    <dbReference type="GeneID" id="28821597"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645207"/>
    <dbReference type="InParanoid" id="A0A194XBT1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268060" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="37885" checksum="669C47B84F3D7F3F" modified="2016-10-05" version="1">MVPSIVKAGVVALSLAVASVHAAEYTLDPTDVYAGAAFFDMWNFITENDPTGGFVDYQSQAQAQAKSLIGFNSAKNRSFIGADYSTVLSPIQTATNRGRASVRIESKKNYTRGLFVADLYHAPANVCGTWPSFWTVNHENYPEWGEIDIFENINENTASLHTLHTTAGCTVAANQGATRQTSTEQSYNCDDQATTGPFGTTQSQYQGCSATSTTANSYGSGFNNQGGGTVVMEWSTHFIKMWTFAPGAVPANILSETPDTSTWGLPSFDTEGGNCTMNDHFQAHNMVFDLTFCGTYAGQSYFWEQTSCYKNNPTAYATCADYVAANPSVYANAYWIINSVKVYQWQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCI4</accession>
    <name>A0A194XCI4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072229.1">
        <property type="nucleotide sequence ID" value="XM_018214769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCI4"/>
    <dbReference type="FunCoup" id="A0A194XCI4">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="GeneID" id="28824495"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683865"/>
    <dbReference type="InParanoid" id="A0A194XCI4"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29067" checksum="CBE9309AB1502DC8" modified="2016-10-05" version="1">MAPYIYKMLLINPNSSEEMTENLEPLITEYPSNTIIDSFTAPRSAPKSINNEKDALESANIVFPEILQFIKQQKYDGYLVACYSLHPLVDMIREAVPRGVYVTGIFEASITTALTLTPTPHLKADVKQKTTFGIVTTGTAWEKLLAAGVLRVVGLGEMAHATRFKGVESTGLNADELHTAPKEVVTTKMKDATKRLVRDNDVRVICLGCAGMSGLDRIVTEALIEELGEKDAKEVYVLDGVKAGIGMLENMFRSLPGSKTEWGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDY7</accession>
    <name>A0A194XDY7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_615087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072719.1">
        <property type="nucleotide sequence ID" value="XM_018210712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDY7"/>
    <dbReference type="STRING" id="149040.A0A194XDY7"/>
    <dbReference type="GeneID" id="28820438"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615087"/>
    <dbReference type="InParanoid" id="A0A194XDY7"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="159"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="604" mass="65181" checksum="4E7BAC00E0BE6B82" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE06</accession>
    <name>A0A194XE06_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_717619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072337.1">
        <property type="nucleotide sequence ID" value="XM_018218360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE06"/>
    <dbReference type="GeneID" id="28828086"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717619"/>
    <dbReference type="InParanoid" id="A0A194XE06"/>
    <dbReference type="OrthoDB" id="5389929at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="110"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="382"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="70551" checksum="E985277EE8FF83FF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE22</accession>
    <name>A0A194XE22_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_781112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE22"/>
    <dbReference type="GeneID" id="28832175"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781112"/>
    <dbReference type="InParanoid" id="A0A194XE22"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="23044" checksum="7F3BD707BDD1164B" modified="2016-10-05" version="1">MDSKTIFDEPPPYEPRDSREQANASSSSSDARPQNYQTNNSAQRNEPSMSRQEPRSFDDFRRDPRDQAYNQSYNSDPRYQNYPDDYIRRGEPAMGRPDPRLNNGYRDPRDQAYGPSYNPDPRSQYYQTGNYVEPPMGRRDFGGFGGMRDTRRGDMYDGDDDYSYGRGRHGRRGRREGGRRRRGGGLIGLVGNLIEGATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEN9</accession>
    <name>A0A194XEN9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_549259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208284.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XEN9"/>
    <dbReference type="GeneID" id="28818010"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_549259"/>
    <dbReference type="InParanoid" id="A0A194XEN9"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34767" checksum="2B50A173FC378B74" modified="2016-10-05" version="1" fragment="single">KMPAPSLNDSCVRACIRNIRSLNDVGSFEYWKIKPVLARITSPEQLHTIELNSPQIRGEDAELWQAFIARDIPNWKQKGYVPKNPLKWYEVYCKYKKEQRMEVQRDEELLKERMMGLQKARQSHVSKVVDLRTLPKVPKDPYMMANNGGVPLKKNPWGKKEPSGFLNFSSGSRTKLTDAKSVLTRARREAKEIGQMSKLSRPTHQLSGKIGQVKKAPAGMSKEYQIAAQPALRILSHRHVQLKNESATRGPSLEEREARLKAAMSSVTRGYASNDVRETLVGSSDDDLNDYDEEDGDDLFDEPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF37</accession>
    <name>A0A194XF37_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_643313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073160.1">
        <property type="nucleotide sequence ID" value="XM_018211792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF37"/>
    <dbReference type="GeneID" id="28821518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643313"/>
    <dbReference type="InParanoid" id="A0A194XF37"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="67"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="551" mass="61021" checksum="35B911682BA7D0AE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFB4</accession>
    <name>A0A194XFB4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_505711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073179.1">
        <property type="nucleotide sequence ID" value="XM_018208017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFB4"/>
    <dbReference type="STRING" id="149040.A0A194XFB4"/>
    <dbReference type="GeneID" id="28817743"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_505711"/>
    <dbReference type="InParanoid" id="A0A194XFB4"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="376"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="559" mass="63225" checksum="8A02FBB7DC17D654" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFG5</accession>
    <name>A0A194XFG5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_696305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073241.1">
        <property type="nucleotide sequence ID" value="XM_018216822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFG5"/>
    <dbReference type="STRING" id="149040.A0A194XFG5"/>
    <dbReference type="GeneID" id="28826548"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696305"/>
    <dbReference type="InParanoid" id="A0A194XFG5"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="14"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="469" mass="52030" checksum="8728545FEE9DEDB4" modified="2016-10-05" version="1">MESWLKQYGASGLDDLELADFSNTGRGVRTLRRFEEGGKILTIPHGVLWTVKHAYADPVLGPALLSARPPLSVDDTLATYILFVRSRGSGYDGLGSHVAALPASYTSSIFFAEAELEICEGTSLYTTTKQLDRQIEADYKELVVRLFGRHQELFPCDKFTIEDYKWALCTVWSRAMDFKLGNGDSIRLLAPFADMLNHSPKVEQCHIYDVLSGNLSILAGKDYEPGDQVLINYGPVPNNRLLRLYGFVVPSNPNDSYDLVLATHPMAPFFEQKHKLWVSAGLDSTSTVSLTLTDPLPSSILRYLRIQRLNESDLAGMVSHKSDAAFEKVSDSNEVEVLRFLVESISSLLDGFKNQLEKLEDQLAEGFYTPEGNAWSAAHVSLGEQRVLRLTRKTAEDLLAAVETGSGNKRRLLSTPAQCAKCKKVSVHLMRCGRCNEVIYCGRACQVAHFKEHKAICRATAAKNGSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH90</accession>
    <name>A0A194XH90_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_494892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073930.1">
        <property type="nucleotide sequence ID" value="XM_018207923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH90"/>
    <dbReference type="FunCoup" id="A0A194XH90">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="28817649"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_494892"/>
    <dbReference type="InParanoid" id="A0A194XH90"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="261" mass="29017" checksum="EE9E3B27A4D12EFD" modified="2016-10-05" version="1">MGVILLDRSNDALNINPPVGTFHLVVHGSDWLWAVCAVYCITLIATILLAYFAKQGEKIFHYLFIISLLTGSVTYFAMASDLGSTAIRTADNTAGTRQIFYARYINWFVGWTPIVLAVGLVSGVSWATIIYNIALVWAWVAIWLAGAMTPSTYKWGFFTFGLLAYFLLSASLLHIGSITAKRLNITRHYSALAGYLVFFWMLYPIAWGVDDGGNKIGVTSGFIFFGILDLFTVPFLSIGVLVLANSWDYRNMNLYFTQYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHA4</accession>
    <name>A0A194XHA4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_612685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073507.1">
        <property type="nucleotide sequence ID" value="XM_018210635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHA4"/>
    <dbReference type="STRING" id="149040.A0A194XHA4"/>
    <dbReference type="GeneID" id="28820361"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612685"/>
    <dbReference type="InParanoid" id="A0A194XHA4"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268247" evidence="2">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="26131" checksum="6D01486F8124228D" modified="2016-10-05" version="1" fragment="single">MAFFFICLLFSNILTFIISTRFSVGSCQPLQDSKTLFAKLERDVPVPFEENTPFTDSNQTLATQLWEDINIDAGMVALPDDLVELHGLREAQRFPWDDSRSIYLLNGYHNLHCIRAIYLSLQEFYRGDEQSRSWGHVLHCADAIRQDILCNADDTPRYSTESKRPESGVGQMRMCRSWDKLDEWAEKYNSCYAYVNQTSEDLPEIQRFVYCPAGSPWREKVVEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHB4</accession>
    <name>A0A194XHB4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_683419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073955.1">
        <property type="nucleotide sequence ID" value="XM_018214698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHB4"/>
    <dbReference type="GeneID" id="28824424"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683419"/>
    <dbReference type="InParanoid" id="A0A194XHB4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="54" mass="5522" checksum="4C89BBDC6E5C1208" modified="2016-10-05" version="1">MALMFVLVRIKDEQATRFRPLLCPLAPPVAAAAAVAVDISAAASFSAGTDSSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJC4</accession>
    <name>A0A194XJC4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_578652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074705.1">
        <property type="nucleotide sequence ID" value="XM_018208956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJC4"/>
    <dbReference type="FunCoup" id="A0A194XJC4">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="GeneID" id="28818682"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578652"/>
    <dbReference type="InParanoid" id="A0A194XJC4"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="33972" checksum="1174596678FFA7EA" modified="2016-10-05" version="1">MSLVGLKNFFFTETVTQAPRSPGSKYNGPLDWSDLSQEPLLHSNDRTTSETAQPTKSDEDTDVESQESLASKTKKSKSKTGFRIDARMISDATIGLSDGLTVPFALTAGLSALGNTKVVIYGGMAELIAGAISMGLGGYLGAKSEAASYHAQRGETQLLVETNPQAAVQSVAAVFKPYGLPKKTLEDITSHLAGSPNLVDFIMQFQHCEEPPAASRALVSALTIAMGYFFGGLLPLLPYFCVGSDQVFEGLYISLAVMVVALFAFGYGKTCIVVGWREGKHIRAGCSGGIQMVFVGGIAAGSAMGLVKLFSSEGDKPATMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJE2</accession>
    <name>A0A194XJE2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_464533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074237.1">
        <property type="nucleotide sequence ID" value="XM_018207707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJE2"/>
    <dbReference type="GeneID" id="28817433"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_464533"/>
    <dbReference type="InParanoid" id="A0A194XJE2"/>
    <dbReference type="OrthoDB" id="3565091at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="2">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="366" mass="38595" checksum="A15BEECF0ECFBDDF" modified="2016-10-05" version="1">MPPGDLWYGVWYKEIQKILSIGGIVVQSGGNTAAQQSGISSIPALWRDRKAAPIMVVGATDNFGVRTYFSNWGTPANFPGTGIDVYAPGLAITVDVANGGSAVKKGTSFATSFVAGLIAYFLNVDGHRAAIEESYANRQKADYSDYFNWQRVVTDYVTTWAYPRSTNPDPTVRMVYNGAIPKGSNAGFVCPAALNYPLVKRGGTNMAPNSCGPPIDPQSSATNTAISSKSVAPTTLLTTTRKSSSSNPATTSHPPPTSTPRPALSKGSSLTPLPPKSSTSQASQISNKIFPTHPSSENSLLPTNPPPITSAHQPSLTLTHHASSSGTSSKIYPITSKSPVPSTTKHQIAPPPPICGRDIQGRMVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJF0</accession>
    <name>A0A194XJF0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074638.1">
        <property type="nucleotide sequence ID" value="XM_018214427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJF0"/>
    <dbReference type="STRING" id="149040.A0A194XJF0"/>
    <dbReference type="GeneID" id="28824153"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682041"/>
    <dbReference type="InParanoid" id="A0A194XJF0"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="429" mass="47249" checksum="AE58C159183DFFB0" modified="2016-10-05" version="1">MFFTSWALWEQMTFILGLAILLVFAIGYGKLLYTNRLVQKQEVVDEEKRMRIQELRSSGQIVESRKSHDIPFGIRAIQSGIQIDGIWISQGSTPVPSELKLGHLRGSSTDMIDPDPNKEAQFSSETTAESLRPSSRQGRPLFRAMDSSNLILDKVYEASDTERPNTARSHASYKPRRASHLRHGSHGQYDEETLGHLEGISPSPKRKVHAHRPRSTPLLDAGADSSAADNEHSSTGVSDSDTSLSHKLQEADSSSPQFFFSEPDVRNATSLSISNVPSGNAVRASLPMQRSKAEYFSVPLDSPRFESSDPFATPLASPLESVPMLKVENSPLVQEPSPPADYQTLPLQPSRSPSPFIPGELHVNKTVRKVNSGFEVLPAGTFGVPPEFKGKGIDLGEDDDSGDRRQSRLQKKPRTSMTVQRTSGTIEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJN8</accession>
    <name>A0A194XJN8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_731230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074347.1">
        <property type="nucleotide sequence ID" value="XM_018219553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJN8"/>
    <dbReference type="FunCoup" id="A0A194XJN8">
        <property type="interactions" value="1030"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJN8"/>
    <dbReference type="GeneID" id="28829279"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731230"/>
    <dbReference type="InParanoid" id="A0A194XJN8"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24235" checksum="1098D8B0ED34E683" modified="2016-10-05" version="1">MSKITVAGVRTNVQELLQYSLETKKRNFLETVELQIGLKNYDPQRDKRFSGTVRLPVVPRPNMSICILGDQHDIDRAKHGGVDAMSSDDLKKLNKNKKLIKKLARKYDAFVASDTLIKQIPRLLGPGLSKAGKFPTPVSHNEDLSSKINEVKSTIKFQLKKVLCMGVAVGNVDMTEDQLISNIMLAINYLVSLLKKGWQNVGSLTIKASMSPPKRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKG6</accession>
    <name>A0A194XKG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_730676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075008.1">
        <property type="nucleotide sequence ID" value="XM_018219501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKG6"/>
    <dbReference type="GeneID" id="28829227"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730676"/>
    <dbReference type="InParanoid" id="A0A194XKG6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13657" checksum="7EB1C8DC124A76ED" modified="2016-10-05" version="1">MCRITIRTFTECQHSINIYEHCASDPLRNHPGAIKGVCKTVAYKSVPNIFEHLRVTFPPGYKKIMNLIAKLETCPNWPSKIKNYETIEVDGTCLAEGGVCSGTRYRLIGYDKNGVVVDRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKP9</accession>
    <name>A0A194XKP9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_579036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075039.1">
        <property type="nucleotide sequence ID" value="XM_018208983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKP9"/>
    <dbReference type="GeneID" id="28818709"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579036"/>
    <dbReference type="InParanoid" id="A0A194XKP9"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="12"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="296" mass="33155" checksum="AEE6DA4F7528BCF8" modified="2016-10-05" version="1">MIDPSLSPIEGYPKLARHMGTYSECAIYRRFACLNSQNLLYFQAELTHLEQKLRRLEAADLVSTGENASIYSKDWYWLNNSASEENSEQLETVRAIRGRLKEYNDVLIQQSIISRLADPNTLNLRSLQNWLERPDMGNLALIGKDRDTWGASDEPLSHNMDLLATKSGGDSDAFSTWVSQKLVYWLHNIFWHRLKRVDDAESGICSYEDKTLQKYTSNITTIVASSLPILAIVVLNCVVAINARLGLMALFTVVFAACLSFFTNATRGEIFIATSTFAAVEVVFISTNNGMSSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKS5</accession>
    <name>A0A194XKS5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075086.1">
        <property type="nucleotide sequence ID" value="XM_018214510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKS5"/>
    <dbReference type="STRING" id="149040.A0A194XKS5"/>
    <dbReference type="GeneID" id="28824236"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682427"/>
    <dbReference type="InParanoid" id="A0A194XKS5"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="290" mass="31705" checksum="3CF5F648AC4122E5" modified="2016-10-05" version="1">MGNDGGSIPTRRELVKNAARALNNTELKAKLLEAQTHAWNTCPLSNRPLAAPIVSDSSGTLFNKDSIIEYLLPQDSDVADKEKDDVLQGKVKGLRDVVEVKFTITKEGKEEKRICPITSKELGPQTKAVYLVPCGHAFSEVAIKEVKGDVCVECNEPYTAENIISILPVAKEDIDRLSKRAETLKASGLTHSLKKAPGAKKRKKGENAEEKTKAKPIVEGTKTATSNGIKNSATASLTAKVLNEQEERNKRRKLAQNENLKSLFSNTGYDAQKQKGGDFMTRGFSLPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKT8</accession>
    <name>A0A194XKT8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075064.1">
        <property type="nucleotide sequence ID" value="XM_018222289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKT8"/>
    <dbReference type="STRING" id="149040.A0A194XKT8"/>
    <dbReference type="GeneID" id="28832015"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779431"/>
    <dbReference type="InParanoid" id="A0A194XKT8"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="17931" checksum="9F88A1731DFD4E02" modified="2016-10-05" version="1">MAVTNAKNRYKDQYCVASTTSTTTTVTATSTTTTTTTTTTTSDSSASTSTSASTITVPTSGFISLDCPALDATTLGITLQSTSLFTVTCGQDFSGPNHDIDILALVVYSLEDCAMACASYNLNWKSTICKAVRFNADLGQVGINYGTCWLKNGTGTIESSNSDTSAGMILQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKV6</accession>
    <name>A0A194XKV6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_416021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075220.1">
        <property type="nucleotide sequence ID" value="XM_018207372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKV6"/>
    <dbReference type="STRING" id="149040.A0A194XKV6"/>
    <dbReference type="GeneID" id="28817098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_416021"/>
    <dbReference type="InParanoid" id="A0A194XKV6"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000355">
        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36055" checksum="08C9B8985E16A7C1" modified="2016-10-05" version="1">MSHRRGPWSQGEDAYLVQLVHTQGALNWVRIAQLIGSRSPKQCRERYHQNLKPSLNHEPISPEEGMQIERMVGEMGKRWAEIARRLHGRSDNAVKNWWNGSMNRRRRIVLRRRTSAHGSSSFDERAQPLSFARPAATRPLTLSSTTYAPRRGVDGPLPSPAVSEASRAESIEGAPSLISDASSVFSTSPRLAKSPSMELPPLLPPFRDTRRPSLPSLPFRPNAFLTDVDSQAAYPFAPRLQSDAKAHNMTATSPAVYPRPGHYHHDMSTPHSPRDYRSDARSQLLTAPPTPIQLAPLQMSPRHEQAEPSADRDSRMHLSSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM43</accession>
    <name>A0A194XM43_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_577871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075603.1">
        <property type="nucleotide sequence ID" value="XM_018208918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM43"/>
    <dbReference type="STRING" id="149040.A0A194XM43"/>
    <dbReference type="GeneID" id="28818644"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577871"/>
    <dbReference type="InParanoid" id="A0A194XM43"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="158" mass="16863" checksum="2C51F5AAA1505BAF" modified="2016-10-05" version="1" fragment="single">MANLLSKEVAVTVSQDARVKNIGDSALLSAIQRRDTEMVQFLIEAGANVNELSNFSTMSFIGTALQAAAARGRTDIVQLLFEKGSNINEPLQGQSAMTALQAAVHFGHVNTAKFLLEHGADVNASATNYEASRTALLTATINKNLVMVKLLLDFGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM56</accession>
    <name>A0A194XM56_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_770462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075576.1">
        <property type="nucleotide sequence ID" value="XM_018221847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM56"/>
    <dbReference type="GeneID" id="28831573"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770462"/>
    <dbReference type="InParanoid" id="A0A194XM56"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268444" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14419" checksum="5BE7A473566FECA8" modified="2016-10-05" version="1">MRFNASLPMILSLISLTLASALPKAYTRSKQWNGTSPNFEIPQNASQYDLLHPGYAAHKHRNSSYADHPLWKPSRFNHSAPWNTSTPGNASTWWGGWNNTVWNQSVNWNASRWNSTGDRHRVVSVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMC6</accession>
    <name>A0A194XMC6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_430859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075599.1">
        <property type="nucleotide sequence ID" value="XM_018207469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMC6"/>
    <dbReference type="STRING" id="149040.A0A194XMC6"/>
    <dbReference type="GeneID" id="28817195"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_430859"/>
    <dbReference type="InParanoid" id="A0A194XMC6"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25003" checksum="D83C9B665CCC24C3" modified="2016-10-05" version="1">MASSDRSEIFLLRLASRDNDGFEDLFRSLMTHAVVKSAKTRPGAIRYLDTNTPKVIIVTDHALTNESNRAVLEKLKSYIRNGGRAIFGFDFCHYLVNRGGRGTFGFEFHNHPAASPSTSFFKEEFGVPWRLCGPGSEVFTLGSGSNLLTGTSVSPFPEQSHMVAVAVMGTGPGEEIYSFEPANNLQPPGDLRPVAIAITPVGSGYLMYFGNIRAAVARLDIRILVALCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN98</accession>
    <name>A0A194XN98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane GTPase fzo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_664901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076085.1">
        <property type="nucleotide sequence ID" value="XM_018212810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN98"/>
    <dbReference type="FunCoup" id="A0A194XN98">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XN98"/>
    <dbReference type="GeneID" id="28822536"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664901"/>
    <dbReference type="InParanoid" id="A0A194XN98"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mitofusin_fam"/>
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    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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        <property type="entry name" value="SARCALUMENIN"/>
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    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
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            <end position="576"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
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    <sequence length="914" mass="100248" checksum="BB8F79FF2B2A4606" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNP4</accession>
    <name>A0A194XNP4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    </gene>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112605" checksum="BA0183374FBFE6E9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR05</accession>
    <name>A0A194XR05_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_680839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">CBS 120377</strain>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KUJ22795.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="359" mass="40071" checksum="D539107FF507E0E0" modified="2016-10-05" version="1">MGLAAPKNKIKISHDPNNTRWTNDTSSFGHKIMTSQGWQPGQYLGAKDAAHAEFHTAANASHIRVSIKDDNLGLGAKIGSGVGHGECTGLDAFKNLLGRLNGKDEDELEKEQKSRDDLRIAIYTERKWGSTRFVSGGFLIGDKIQHLIDAEAERIRKLALGSSTESSCSSESEEEETPVETTKKSKKRKAETLEEPEVVVVKIKKSKKDRKAEAASEAIKETSNPDGAKRSKKSKKDRKSTVETDEIPDEIELKRRRKQERKEKKERRERTKFEAEATEEEPKKKKKSKKDKHKEAEGSSESTTKESTPATPMAADSIGRSTPIMMQGRHAVRARNIAQKRMASMDVASLNQIFMIKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRR2</accession>
    <name>A0A194XRR2_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_313263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077238.1">
        <property type="nucleotide sequence ID" value="XM_018206649.1"/>
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRR2"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_313263"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="19521" checksum="39F7CBFED08D2B28" modified="2016-10-05" version="1">MSKPSKSSSSSSSSSRTPTKRILTELTAFNTTYPPTSPHPSIHSLLPTPSNLLSLNCILQPTHLPPSTGYSTGRFLLSISIPPTYPNNPPTITFLTKICHPNIAWATGEICLDVLKENWTPVLGVVGALESVVRLLAEPGVDSPLNVEMGALLRQGDVVGARGLVGYWCAEERFEGALEGGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT04</accession>
    <name>A0A194XT04_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_776975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077529.1">
        <property type="nucleotide sequence ID" value="XM_018222093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT04"/>
    <dbReference type="GeneID" id="28831819"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776975"/>
    <dbReference type="InParanoid" id="A0A194XT04"/>
    <dbReference type="OrthoDB" id="5279375at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="79" mass="7579" checksum="707884C1192E7BC6" modified="2016-10-05" version="1">MSGTYKPTEHGGLKEDGTPDKRVGTGEFAQGKVDPVEAGKQGGQTGGSSGGSSSGGSGAGEFAHGKVDPVEAGKKGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTK0</accession>
    <name>A0A194XTK0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">beta-glucosidase</fullName>
            <ecNumber evidence="5 14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_636010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5 14"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078000.1">
        <property type="nucleotide sequence ID" value="XM_018211470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTK0"/>
    <dbReference type="STRING" id="149040.A0A194XTK0"/>
    <dbReference type="GeneID" id="28821196"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636010"/>
    <dbReference type="InParanoid" id="A0A194XTK0"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268653" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="714"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="791" mass="84594" checksum="4569134E37BC7E7F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTK5</accession>
    <name>A0A194XTK5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_728376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078005.1">
        <property type="nucleotide sequence ID" value="XM_018219258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTK5"/>
    <dbReference type="GeneID" id="28828984"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728376"/>
    <dbReference type="InParanoid" id="A0A194XTK5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="22325" checksum="A1B7459FF82B7441" modified="2016-10-05" version="1">MVLGPLDRRNLKTRCQACARRRIKCVGSRPCFYCNKRKIQCLPQASNNCANLVFVNTRSDLVADPSPAPGSEEDIALARFFTVFMERNDFAGEHLDTSGIISSFQASPSLYHATLAIGSLDLRTTSSSLKDRRAITASALLSYQTAIKSFKSDMQHSDVRRSHAALWTTFFLGLFELMYDVTGQGWVKHILYGTSSILQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUL7</accession>
    <name>A0A194XUL7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_726888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078186.1">
        <property type="nucleotide sequence ID" value="XM_018219097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUL7"/>
    <dbReference type="GeneID" id="28828823"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726888"/>
    <dbReference type="InParanoid" id="A0A194XUL7"/>
    <dbReference type="OrthoDB" id="10510804at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31649" checksum="94E9325F6E0B2A22" modified="2016-10-05" version="1">MVQLLADCLPNHTSGMLDHDFVYLEAHVNKLKGGYFYHNTPKSLTGYPQKPPSNLNDLKELWTALTLTILVFGYLNDPLVVSKYNCVSQRMRKMLEEIARQSREDRSPTQQWALWDSWEPFASSERLVKIFNSWERGFLNQVEKRMQKAVRVGLNKIAAFEPMDQAEAEFHAWCKQKLGCQAFGQSPRGLGLALSMLDQTRKEKEDWISHDDQTLDEHVSQTELGELDADLGASSTNDVETEDLGQADGGGSIGKNWAANWLSDEETMFRLLTGAEEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUW7</accession>
    <name>A0A194XUW7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_184048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077857.1">
        <property type="nucleotide sequence ID" value="XM_018205644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUW7"/>
    <dbReference type="GeneID" id="28815370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_184048"/>
    <dbReference type="InParanoid" id="A0A194XUW7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="20468" checksum="9B17001FDC86141E" modified="2016-10-05" version="1">MGIVIVLGLEKNGDRGTSRGERVVQVVVVVVVVVCLLRWPARLSRIQDHPQRWHTSLLGNLDFWDSGAVHGPTISQGFASDWRPYELVNRSPSLLVHCCGLQWSGVEWASISASALRNHPALSSSSSASRRPGPCTSFRWMDGRESRTMSPSEDEGSGRGHRSLLVLAVLYCTVRVRWLVLVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVL6</accession>
    <name>A0A194XVL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_713156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078628.1">
        <property type="nucleotide sequence ID" value="XM_018218032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVL6"/>
    <dbReference type="STRING" id="149040.A0A194XVL6"/>
    <dbReference type="GeneID" id="28827758"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713156"/>
    <dbReference type="InParanoid" id="A0A194XVL6"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="359" mass="39607" checksum="020D01D50EC1A665" modified="2016-10-05" version="1">MGSIHYEEPKLAPVPVEWTSSEASASEGNKLVVFHVHGGAFFQGSPQSYRSTTTQFASMTGGRVVSVDYRLAPQNPFPAGLLDVLLVYLSLLYPTESETPAVDARNIVFAGDSSGGTLLCSILQIILHTADYSTCQFRARRIHFPLPLPAGLSVISLPGDLLQSLPSHKENLVNDLYLNIPWSFPDYPACPIWPSNPPRSQHYGDLEIHSHPLVCSVMIKSWLGAPPFWISSGEEQFLDGGKAVARRAASQGVGVSWTVYEAMPHCFSMLPGLNQSAQSKLIMKKWAQFCKECVLSPNSFKGRVRASKVDFRTVTETQVAFEDPRDLPINEIEGLILRKILDLEREFTGAWKAKTCSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW30</accession>
    <name>A0A194XW30_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_727542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078875.1">
        <property type="nucleotide sequence ID" value="XM_018219161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW30"/>
    <dbReference type="STRING" id="149040.A0A194XW30"/>
    <dbReference type="GeneID" id="28828887"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727542"/>
    <dbReference type="InParanoid" id="A0A194XW30"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ24520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="855" mass="93777" checksum="B1199FAE0387FC20" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ24541.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="741" mass="83463" checksum="3E7518EEB3DBBBE6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWP3</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_679662"/>
    <dbReference type="InParanoid" id="A0A194XWP3"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ24551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="638" mass="71769" checksum="6FED1D92BABD0A93" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1H9</accession>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_678962"/>
    <dbReference type="InParanoid" id="A0A132B1H9"/>
    <dbReference type="OrthoDB" id="4357582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="48839" checksum="BCDA019F583C3C16" modified="2016-05-11" version="1">MHTMQPVTRRVVGLMLRSPTEMESMFRHLLQRWMPNSDLLPSPDCSLSGSSHLQHAAGCTGGNGAEFAPGIVVDSVAITELGVVSAGRPTLSTSRCRGDAVLLNIPMITLVRRVMWVCQLNAGQASASASAIGEMAESSAKAGTGKGLHYCHPMFETTTGLPLVFNPIIFLLAMALASNAFKDYQTDDEIFALEPPVYDEIEDVPVFQATSCNGPTGKIQKACTCARQLSGAAQRAGFLNCTVYAIRREALVKANANGYADAELMKFSEQSGPEVFQTFYMAEGGVDGQNSFLNQPLRKDHLESFRGMFMQCNPELWQSLPAQMRYELEEQIDDLTKEIKTADEEASRELQARRHKLHKERQRLTLEELKKRRQSQPRNHQSHGAHEPSQGDRHRSFFGRVRHIMPKRNRLARTLFQPPTGPPPQPRRPVCSSEPHRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1Y4</accession>
    <name>A0A132B1Y4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060750.1">
        <property type="nucleotide sequence ID" value="XM_018220994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1Y4"/>
    <dbReference type="GeneID" id="28830720"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743872"/>
    <dbReference type="InParanoid" id="A0A132B1Y4"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42628" checksum="2110850D3A1BF893" modified="2016-05-11" version="1">MASPDYTELFTFPNGDVEIVVNFKGETIRGRVNSNNMTAASKVFSLFINPPWVIKEPEIETTTASTDGVRPDPALKCIECSDDDGYALLVLLRLIHIQLGGVPDTLPTDTLLKVAALVEKYDCRNLIHSWAALWCAEATTKAKDGDADTWLYIAWAFGRRELMEDMARKILLEATVSEAGQLMVYDKENVTQVRQIQELQPFGFEDNVRAIRLQTIQDLLDVAYAHVSRFGGLKQIPCDVKDKHSADCASNRYCEQVYKLRKLGLFPRVTADRANISIEKLAEEVKNMGKRDIPYNKGHEKCFKGTYERDVERIMSNLGDPVLDSHRTHTEPRHRKGPEDPLMSLTEKTEKENGKDFEDDADMYLIGLLQRTNPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2C2</accession>
    <name>A0A132B2C2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060748.1">
        <property type="nucleotide sequence ID" value="XM_018216556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2C2"/>
    <dbReference type="GeneID" id="28826282"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692520"/>
    <dbReference type="InParanoid" id="A0A132B2C2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="22910" checksum="D58C3D438706C2BB" modified="2016-05-11" version="1">MGSSSSSPVSSRSASLNRGRLSSLTPDSDLKSISPIAPIMQLARRPGFSLSNSTQDSFQTSRPIATPTSSRRSTSTTPGPPLSPMSRIRLGISEDNKARRSNPSRAHRRPPIIESPEVEESTCHCPLGHKDFDTCSADPHSIYYKSPSPETPAMDKKSRATTTPRGSRKRKAISYLEEEAKYVCGCGGGHDDDLECEYASTLKKHVEITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Q1</accession>
    <name>A0A132B3Q1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_412547</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060652.1">
        <property type="nucleotide sequence ID" value="XM_018207341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Q1"/>
    <dbReference type="STRING" id="149040.A0A132B3Q1"/>
    <dbReference type="GeneID" id="28817067"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_412547"/>
    <dbReference type="InParanoid" id="A0A132B3Q1"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="17">
        <location>
            <begin position="310"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ06297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="825" mass="93897" checksum="F1C211E808393694" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4Z9</accession>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="23601" checksum="27C7A7DD0368E291" modified="2016-05-11" version="1">MDWLKGGDGARHMESEKMNLQEQDTLRVHDHDQLPIPIENERTIPLNDSAYASVALRAGQDHQQSLRYFDQQNGPDVSGLGTIARPITKSPSIDDGNAGNIGDLYVQQGILGRGAYAIVKKVVHKTSGQVFARKCYIVAGPNAEYIKHQFTNEIEIMKSLPEHHHMISYVALIRRADNFPFLFSRLPILDHWQTISMTSEKEVSHLGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5J5</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
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        <property type="protein sequence ID" value="KUJ07686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206921.1"/>
    </dbReference>
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        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B5J5"/>
    <dbReference type="GeneID" id="28816647"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_351330"/>
    <dbReference type="InParanoid" id="A0A132B5J5"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
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    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="22233" checksum="65A565414CA151BE" modified="2016-05-11" version="1">MGVAKKTRKFGAVKRLIGQNDARLKKNISKAEDEAKKKAKENQVVREVPQVSSALFFQYNTALVPPYNVLVDTNFLSHTVQRKLELLETMMDTLYAKCIPIITSCVMAELEKLGPRYRIALRIARDERFERLKCSHAGTYADDCIVDRVQQSKIYLVATNDKDLKRRIRKIPGVPIISVARGKYVVERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5Q3</accession>
    <name>A0A132B5Q3_MOLSC</name>
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        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A132B5Q3"/>
    <dbReference type="GeneID" id="28830558"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742517"/>
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    <dbReference type="OrthoDB" id="3562663at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="828" mass="93147" checksum="5E77B82D3D791DE4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7A1</accession>
    <name>A0A132B7A1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_711686</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kennedy M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="374" mass="42132" checksum="400D2F2246B0FEBD" modified="2016-05-11" version="1">MSIDRSPALFGDLPDELLIQILGDLSARDLSAICLVSKKLNKLADPILHKSVAFDHPRHHVSFSESLARRPRRGSLIHEVRLEYPSEELSEVMAIPESPHPLRFDHFSHTISTMSNLENLEVSVPEALSHGIGNLFNGPFDLACLKTCSLFYQREDGGYWDLQENIHIFSHPTLESLTIRRAKLDQRGFESLEKPENTALKELHLLECDINDDALADILLHPEALQEITITQVADPTPELEESPLDIGDYILALSSANHSLVTITIDFPTLVAKHALRLREFQALKSLTLRDYQLIGQGHPRLHSVGLPPILEKLNLLGRLGEDEEIAELLCYTLEHTLARQQCTIAVSEKEHKIPVEIIEACKKSEHFHLEID</sequence>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="134" mass="15527" checksum="9EA2C20C1361F712" modified="2016-05-11" version="1" fragment="single">VNISVTYDHRLRKTGHPVRSAIHKPQIGRLVVGWVTTSEYLLLYVFDFCRSCKNFPCGDAAGKFRFWLADPVICHLKCNLDVQHLFEYCRNIYFHLNLLHKCCATFCNILSAFRIGTCEELPHSPFYPTFANIL</sequence>
</entry>
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    <accession>A0A132B7F9</accession>
    <name>A0A132B7F9_MOLSC</name>
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        <lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
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    <dbReference type="GO" id="GO:0035091">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="648" mass="70942" checksum="E83F8D3B097A5C03" modified="2016-05-11" version="1"> </sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08386.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="394" mass="43191" checksum="5CCB0857833BCBC8" modified="2016-05-11" version="1">MKAPILPPKTEQLLGHLLASLPAASISPSPPTALLPLLSPILRQRVQLLSASNQEPWLPLLCYDSTKASKLEEVVKNERFEPHPVSGEVEIDWDYDVDLRYKRTDEETLQSLASLHELDLSVKLVWCVNDEIGGGDGWRIGEVAVYEPSVDSTWGQSNISQAEEAYENYSTPLLSSHNRSNGTNGLLTPDADAMDEDEDDDDDYWAQYDNTPARTPAPKDSGIAPMTSLSDERAHHDDDEASYYAQYSSVQPAMDDHDPDEAEQNGTVESSLGRDEIAQELQQSLATEHEHSSASAWSQLQEPNDDGMFTSDEILHPRPGSSTGSSGSDTVAKLEKGAAASAALEQSEVGIKQHIGTSVKSLYRLAKVAGIERGEFERIVRTELDCLGLMDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8S0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063150.1">
        <property type="nucleotide sequence ID" value="XM_018212476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8S0"/>
    <dbReference type="GeneID" id="28822202"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658493"/>
    <dbReference type="InParanoid" id="A0A132B8S0"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="614" mass="66564" checksum="6AA23E2B5B9FECFE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Y3</accession>
    <name>A0A132B8Y3_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_764330</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="289"/>
        </location>
    </feature>
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            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="33959" checksum="B4AE6225B82F8F79" modified="2016-05-11" version="1">MSTCYYRAHRILTRSSTTTWKPFAHHLGEVERKFLDNITDIDEDQINQFRNSGLSNLTTQCNSMDPESYQVFHRYFNVFNRMFFFHSFNRRNCTIRMIHRDGDDSMEWEANKDSLEEVYGHTLREPYGRPHREIVHCPITIFQRPWDTPESRLKSYIETLLHEMVDAFIVTYTCGCEICQELFAQEYGQRGHGETWHAMATALEETVTDRLGIDVSLGIPAAMSDEWYRTNADLDGVDLRRLDRSSIEKLIEQCWFYNGDPSGENDDDNDDNEESDASEDSSEEEYIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B945</accession>
    <name>A0A132B945_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_328662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B945"/>
    <dbReference type="GeneID" id="28816494"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_328662"/>
    <dbReference type="InParanoid" id="A0A132B945"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="129" mass="14862" checksum="B623E5F84772FCEC" modified="2016-05-11" version="1">MVRLGLYCAAGSFSSMLYSRSWLYPSTYPRHDHLLVLKSINFYSVWDVSTNVFEVVEYYLWGCRNELCGTLCSKLHLKHPSSQWVLISQKQVGSTSNKTPCFVKNIQSIFMCQSTTRLVPPSQTPMHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B954</accession>
    <name>A0A132B954_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_690508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B954"/>
    <dbReference type="STRING" id="149040.A0A132B954"/>
    <dbReference type="GeneID" id="28825836"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690508"/>
    <dbReference type="InParanoid" id="A0A132B954"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="746"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="825" mass="88845" checksum="20CAE04CCF919264" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9J7</accession>
    <name>A0A132B9J7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper radical oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_741374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063433.1">
        <property type="nucleotide sequence ID" value="XM_018220701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9J7"/>
    <dbReference type="GeneID" id="28830427"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741374"/>
    <dbReference type="InParanoid" id="A0A132B9J7"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288019" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="38"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="294"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="407"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1028" mass="108301" checksum="79E72F429A97DC6F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAI5</accession>
    <name>A0A132BAI5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_598522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063628.1">
        <property type="nucleotide sequence ID" value="XM_018210046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAI5"/>
    <dbReference type="GeneID" id="28819772"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598522"/>
    <dbReference type="InParanoid" id="A0A132BAI5"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="317"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="695" mass="78997" checksum="597BC20C4FC07435" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAZ3</accession>
    <name>A0A132BAZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional fatty acid transporter and acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_711225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063798.1">
        <property type="nucleotide sequence ID" value="XM_018217888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAZ3"/>
    <dbReference type="STRING" id="149040.A0A132BAZ3"/>
    <dbReference type="GeneID" id="28827614"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711225"/>
    <dbReference type="InParanoid" id="A0A132BAZ3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="512"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="635" mass="70748" checksum="FBDBBA775DFB9500" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBD0</accession>
    <name>A0A132BBD0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_787965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064043.1">
        <property type="nucleotide sequence ID" value="XM_018223122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBD0"/>
    <dbReference type="GeneID" id="28832848"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787965"/>
    <dbReference type="InParanoid" id="A0A132BBD0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="10462" checksum="9F74C2906371FDC7" modified="2016-05-11" version="1" fragment="single">PSSSIGLLTITITITPPLPPPRNPPPDLPLRPPLPPNPPPSLGSSNRPRKIIQHDSPPAAHWDFFPISKFISSQVPASGVRKQYSPAGKNPNRVVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBT8</accession>
    <name>A0A132BBT8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase GroES-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_710801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064247.1">
        <property type="nucleotide sequence ID" value="XM_018217861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBT8"/>
    <dbReference type="FunCoup" id="A0A132BBT8">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="GeneID" id="28827587"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710801"/>
    <dbReference type="InParanoid" id="A0A132BBT8"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="8"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="350" mass="37175" checksum="E9C2BC1AE7072199" modified="2016-05-11" version="1">MKAIISAGPVGYRFVEDFDIPTPRPRSILVRVHAVALNPRDGKMVDIGTATGSLAGCDSSGTVVTVGEGVTRFKEGDRILAVTFGSNTSDKTKGAFSEFAFADEDFSCHVPERLTFVQACSIGLSVATAGLGLFQAPGLMLSMEHGSGETVLISGGATATGTMATQLLKVAGYHVIVTCSPVNNDLCKSYGASACFDYHSPTCGADIRVHTNNSLRYVLDCVTDTPTMKMCYESIGSSGGSYIALEPIAVDVKYTRRDVRAGWFLTDAIAGDGIQMSGTYGRPPTPEYRQYGKELFALVERWLQEGSIVLHPIEVLDGGLRNLPGAIADMKLGKVHAKKLVMSVLATGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCU6</accession>
    <name>A0A132BCU6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_596701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064600.1">
        <property type="nucleotide sequence ID" value="XM_018209936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCU6"/>
    <dbReference type="FunCoup" id="A0A132BCU6">
        <property type="interactions" value="1582"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCU6"/>
    <dbReference type="GeneID" id="28819662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596701"/>
    <dbReference type="InParanoid" id="A0A132BCU6"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="616"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ10245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="675" mass="73490" checksum="5AC7CD20C83CEF70" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDM6</accession>
    <name>A0A132BDM6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_263277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064871.1">
        <property type="nucleotide sequence ID" value="XM_018206292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDM6"/>
    <dbReference type="GeneID" id="28816018"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_263277"/>
    <dbReference type="InParanoid" id="A0A132BDM6"/>
    <dbReference type="OrthoDB" id="3565357at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="15263" checksum="42E74E0B26AC6E90" modified="2016-05-11" version="1">MQLRNRLVGAGQAFHQFKRLPTEIRCMIWKFSLQPRVVEIATDIQVVEDTPYPGDVYEGTYYYSKARLPAILDVCHESRSATLPLYPLCFRYSGPGIRFNVSFDILYINHDVEDIRNLLDFLKNTSKRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDX2</accession>
    <name>A0A132BDX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_760855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064389.1">
        <property type="nucleotide sequence ID" value="XM_018221525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDX2"/>
    <dbReference type="GeneID" id="28831251"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760855"/>
    <dbReference type="InParanoid" id="A0A132BDX2"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="770" mass="85711" checksum="CF942E025F254F74" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSR0</accession>
    <name>A0A194WSR0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_710605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217840.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194WSR0">
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    </dbReference>
    <dbReference type="GeneID" id="28827566"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710605"/>
    <dbReference type="InParanoid" id="A0A194WSR0"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="60306" checksum="F93C58436BBE4382" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT19</accession>
    <name>A0A194WT19_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722966</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065460.1">
        <property type="nucleotide sequence ID" value="XM_018218775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT19"/>
    <dbReference type="GeneID" id="28828501"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722966"/>
    <dbReference type="InParanoid" id="A0A194WT19"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267490" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11040" checksum="CC5F8E9A7E4B640B" modified="2016-10-05" version="1">MNKLTILLALSVLFVGITGFPSTVTNETIIARKDSQECKKNGTYCSSRQDFFSGDDCPGSPSRFLVHCALWGHYSTYQECYSGPCIEGEDKNGSDDKCAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVK9</accession>
    <name>A0A194WVK9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722739</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065982.1">
        <property type="nucleotide sequence ID" value="XM_018218753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVK9"/>
    <dbReference type="GeneID" id="28828479"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722739"/>
    <dbReference type="InParanoid" id="A0A194WVK9"/>
    <dbReference type="OrthoDB" id="3559929at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="316" mass="35066" checksum="C28E85B4EE7E62AE" modified="2016-10-05" version="1">MGAKCVDVGDANPDIAGIGIILSFSIQAGIAIVTSFYSFYLEWRVGPRSKSEGVAPYQEQLKIANEILLQGGDVQVMTGISLLLAAISQIDSLQLYHLHIVYDTVSFVGISLCASIACSFSPDMDGKYIRYTLIAIWALLYLAYASLFGTQLQSWNYDKTGHCYITSRIATADASHPYFDTIYLSITCLYVNIALIFAFSVTSNQPKIMSQLLCMYLAALQFPLHVYSVSALRKSNEPVLNSGSSEQQWGFGQVVAMILLANNVIVLLNGIQERRVKLMNPPPLSPRFQPYQQCRLFIIITKETSDELFASMLYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVR8</accession>
    <name>A0A194WVR8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobic surface binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_220767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066421.1">
        <property type="nucleotide sequence ID" value="XM_018205942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVR8"/>
    <dbReference type="GeneID" id="28815668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_220767"/>
    <dbReference type="InParanoid" id="A0A194WVR8"/>
    <dbReference type="OrthoDB" id="3485059at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267513" description="Hydrophobic surface binding protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="17775" checksum="465E707EA682D34C" modified="2016-10-05" version="1">MVIIKNVLLLVTAATALTLGKRDVNTILSDISTIDSNVKALTTAANNYNGGVLAAIPITSAESTLDKSINQGTSDAQATSQLSSADSKSILAAINNLTPDIAASLTAVENKKANFAADGLTSIVQNDLATLKSDTDAFADALIAIASADSKDQATAQKATIDSDFQGAIDDFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWG9</accession>
    <name>A0A194WWG9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_652712</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066650.1">
        <property type="nucleotide sequence ID" value="XM_018212215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWG9"/>
    <dbReference type="FunCoup" id="A0A194WWG9">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWG9"/>
    <dbReference type="GeneID" id="28821941"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652712"/>
    <dbReference type="InParanoid" id="A0A194WWG9"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="202"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="449"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="735" mass="80412" checksum="4848E1D1CC15F921" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWP9</accession>
    <name>A0A194WWP9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_593672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066362.1">
        <property type="nucleotide sequence ID" value="XM_018209762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWP9"/>
    <dbReference type="GeneID" id="28819488"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_593672"/>
    <dbReference type="InParanoid" id="A0A194WWP9"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="406" mass="46120" checksum="9F2DE3C5D5F27CA7" modified="2016-10-05" version="1">MLLPKGGVTWKSAKASLPPTRAIWVFLTRTRFLLCVALAGIVLLLWRGVSTSASEMQRFYCWGPSKPPMQMTANEAVDWNAHLQTPVIFNHHEPLVINESSIKRVDLNPILSTPKAVSNEERVLILTPLRDAAPYLPKYFDLLSELTYPHHLIDLGFLVGDCTDDTLAVLSAELARIQKTTDTLSEPFNSALIIEKDFGIVTAQNVEERHGFKAQAPRRKNMARARNYLLTSALKPEHSWVYWRDVDIVDSPKKILEDFVAHDRDIIVPNVWFHRYKDGKDIEGRFDYNSWIESDKALRLASTLKKDDIIVEGYKEYDTGRTYMAKMGDWRQNKDEEINLDGIGGVNIVVKGDVHRSGINFPCYAFENQAETEGFAKMAKRAGYEVIGLPNYVVWHIDTEEKPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWR8</accession>
    <name>A0A194WWR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_652883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066776.1">
        <property type="nucleotide sequence ID" value="XM_018212221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWR8"/>
    <dbReference type="GeneID" id="28821947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652883"/>
    <dbReference type="InParanoid" id="A0A194WWR8"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="55464" checksum="B597C3383E691B10" modified="2016-10-05" version="1">MAAATLSHRLSMISLTSTQAGRREFTRLEKQAAAGHLTQVWSDLEADLPKPLEHRFVDLKKRLVPPEQYEALQASWDRLRIALKERAVEIEAAGPDYIPTVLFTSIGPDGTFPEDIAKLIKSRGCCVIRGVVSREQALKWKSDLMDYVRKHPLIAGPPSAQDPQIWKTYWTKPQLEGRTHPDMIKAQVAMSKLYSCDEDTEVDVGSQALYADRFRIRWPGDSGTLPYHLDNGSIERWEDEENSKTFSAIWEGRWEEYDAFDMNHRTEACVDLYGGPGACSVFRSLQGWLSLADNGPKCGTIELLPDIKLSTAYILLRPFFDANNKLDMESTYFYGADPGFGQVVKDTWHPDLQLSKTVVAAPKAAPGDYVFWHCDMVHKVEEKHEGTKDSSVMYIPIVPLTAYNISNLVEQRKAFIEGVPPPDMISRDGEELEKEHEDRGLAKDILTLGGKRIFGLAPFDLTEDGITRGQIEVRRLANEALGFNDLATYDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWS7</accession>
    <name>A0A194WWS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_785796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066786.1">
        <property type="nucleotide sequence ID" value="XM_018222922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWS7"/>
    <dbReference type="STRING" id="149040.A0A194WWS7"/>
    <dbReference type="GeneID" id="28832648"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785796"/>
    <dbReference type="InParanoid" id="A0A194WWS7"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="627"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="915" mass="101937" checksum="565EF73627A5BEE8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXH7</accession>
    <name>A0A194WXH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_687653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067038.1">
        <property type="nucleotide sequence ID" value="XM_018215550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXH7"/>
    <dbReference type="STRING" id="149040.A0A194WXH7"/>
    <dbReference type="GeneID" id="28825276"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687653"/>
    <dbReference type="InParanoid" id="A0A194WXH7"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="101"/>
            <end position="424"/>
        </location>
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        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
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        <location>
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            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
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        </location>
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    <feature type="active site" evidence="5 6">
        <location>
            <position position="363"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="842" mass="93057" checksum="F48510B2CA7AD978" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY08</accession>
    <name>A0A194WY08_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
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        </cofactor>
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    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="443"/>
        </location>
        <ligand>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="503" mass="57267" checksum="9A1708466FD42A83" modified="2016-10-05" version="1">MFLIGRIVFFAIGYRIFRAFYDLYFHPLTGIPGPKLAAITYLYQTYYSLFVGGSRFYIQIGKLHEQYGPVVRITPDEVHLSDPENYDSIYYIGSKYAKVEQYYASMSCGYSSFTTMSNEAHRIKRARLNPFFSKKKIIEFESIIQSNAKKLCDLVARKFEEGEEMDLHHGYRAVSVDVITDIAFNQCYNLLDRKDIGEEFFTLFEKMGSTMWVFQQWPFFMRMAESLPPKWGAKMSGPLAQVFRIQNHCSEAIASVEVDIAAGNKSAARQTIFHDLLTPDPEQGWVVPPEVHLRDEAFAILGAAADTTGNAMNFATIEVTNDPVMYKRLCDELREAFPNPNAKPDFLTLEKLPFLTGVIKEAFRLSFGSPGKLSRVVPEGGATFNGHFLPAGSFVSMGTWELHHNETYFPNATKFDPDRWADPANVKHMEKAYVPFGRGTRMCIGINLAYAELYVVLGNMFRRFDNMRPNELKPEDRVYNDYISARVPLTATRFHVSAGEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYX9</accession>
    <name>A0A194WYX9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_672408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067523.1">
        <property type="nucleotide sequence ID" value="XM_018213285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYX9"/>
    <dbReference type="GeneID" id="28823011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672408"/>
    <dbReference type="InParanoid" id="A0A194WYX9"/>
    <dbReference type="OrthoDB" id="10552390at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="165" mass="19255" checksum="59BD576AA05F1909" modified="2016-10-05" version="1">MASTAIHTSPMYHRFHNIAEDVIYRQNTFEIWDSDLWFDGFIYGLSPFARNNPANLRVQWPIPPTERPEQILGWIAHCSGVKRLEFFCFSQRVSISALQFLDRLPIENIWFETSTCQVPNLAALRYPNGVPSRHRIHRMVRAQSTQTDINTDFQTQGGLEGFRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ72</accession>
    <name>A0A194WZ72_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atrazine chlorohydrolase/guanine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_652415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067364.1">
        <property type="nucleotide sequence ID" value="XM_018212200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ72"/>
    <dbReference type="STRING" id="149040.A0A194WZ72"/>
    <dbReference type="GeneID" id="28821926"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652415"/>
    <dbReference type="InParanoid" id="A0A194WZ72"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000014">
        <property type="entry name" value="5-methylthioadenosine/S-adenosylhomocysteine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054418">
        <property type="entry name" value="MQNX/HUTI_composite_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22039">
        <property type="entry name" value="HUTI_composite_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminodeoxyfutalosine deaminase/Imidazolonepropionase-like composite" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="55"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="462" mass="50402" checksum="67063C032E42763F" modified="2016-10-05" version="1">MLYLHATLVTVNPDRDVILDGAILVKGDKIADIGKSEALIAKHPDEEHVDLTGRIIIPGLITTHMHTAQTLLRGAADDLELVSWLCERVWVMQGNFTAEDGYAAARISIAEMLLTGTTCFLESMFADRYGFDGLCRAVEESGIRGCLGKIVMDIGTYAKDSAWVMHPGLVENREMSLLGALSMHEKWDKKADNRIRVWFGARTPGGVSDGLYKEMTAISKEKNIPITMHCAEVKADREFFAAQDHTPMSYCNSVGLLGPSTVLVHMVHLDDSDIAKLAETGTHVAHCPTSNAKLASGICRLPELLNSGVNVGLGTDGAPCNNTNDLLQEMKLAAIIHKAKSYDPTMINAEQVMEMATINGAKALGLQDSIGSLEVGKKADFVSIDMRKVHLQPYFSAVSAVVYCATGKDVEMVVVDGKVVVKEGKLQTMNEEEVWKEADVRAHQILKRAGLTEKVKGRWPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZI2</accession>
    <name>A0A194WZI2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_651541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067713.1">
        <property type="nucleotide sequence ID" value="XM_018212166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZI2"/>
    <dbReference type="STRING" id="149040.A0A194WZI2"/>
    <dbReference type="GeneID" id="28821892"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651541"/>
    <dbReference type="InParanoid" id="A0A194WZI2"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="33592" checksum="D2083140D2BF3A54" modified="2016-10-05" version="1">MSYPKNVGFIGLGVMGYPMAQNLAAKLPQSTRIYVFDVATQVMENLVKEYPGKITACQSSKEITSKCEVILTMVPEGAHVKSVFLAPDTGVLATDISGKIFIEMSTIDTATSEDVRGKVAAASPSALFYDAPVSGGSLGAQNATLTFMLGCSEEDPNWPLLKSLLGLVGKSIFPCGGPSLGLIAKLSNNYCSGLIAIATAEAMNIGMKSGMNPALLASIFATSTAQSTISDKWNPVPGVCPTAPASNGYRGGFKVQLMRKDFALAMDAAKRVNARLALGEAGLQTYTDASNDPACRDLDSRVVFRYLGGSEEWKKEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZV9</accession>
    <name>A0A194WZV9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_699108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067507.1">
        <property type="nucleotide sequence ID" value="XM_018217033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZV9"/>
    <dbReference type="GeneID" id="28826759"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699108"/>
    <dbReference type="InParanoid" id="A0A194WZV9"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="729" mass="79868" checksum="E6ED52EC229BD940" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZY6</accession>
    <name>A0A194WZY6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_737160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067532.1">
        <property type="nucleotide sequence ID" value="XM_018220222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZY6"/>
    <dbReference type="GeneID" id="28829948"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737160"/>
    <dbReference type="InParanoid" id="A0A194WZY6"/>
    <dbReference type="OrthoDB" id="4860140at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="171" mass="19886" checksum="F3E4377F2B361BD8" modified="2016-10-05" version="1">MKNSGISDIPIRFKRDKLPLPIFRRLSGGADRKLSPNLPWGCSSVNSEAQRIFREVGFEGRYTFYNLRRTMGNTLDDYGTSITRRKRIMGHHGKSDTIFRKAYQSRKNTVDTGNIFRKEKPRPEKQEVLSMHLRMDTDVLEAPKSLLKQILEHDAEIKEMCNTRNLRLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X089</accession>
    <name>A0A194X089_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_754499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067965.1">
        <property type="nucleotide sequence ID" value="XM_018221330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X089"/>
    <dbReference type="GeneID" id="28831056"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754499"/>
    <dbReference type="InParanoid" id="A0A194X089"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="49497" checksum="B77B9BC0B8ECFF7E" modified="2016-10-05" version="1">MAALQPALENTPRPTTFKLRDSCHACASSKVKCHKEKPTCSRCAKRGITCEYFVTKRVGRKHENRSTDKSYTTAKTPQSNIPIPIEPASQSTSSEMNYFLSPGLLQPSPGQTTTSNSSDNFSTLFSPVDSFLSSVLTSLSTGFDDFSNTSVFPESSDFDMLNQSNFYLGDGNNSSKSGTDSVGFLNAQVNYSIFDEPVSELSNLSQPQSPPSSHGSSTSDLQGNHTVHTSADSPCFCLIRGLGLMKQLSPIAPAAQTISTGEGNQTTTSQTPTVQTVIAENEQIVEAVGNMLQCQCAQDGYLLTIMALIVFKVLGWYAAAARGTSASEDDNRSPTKPPHSRKPSCHAEQVLQDPTVVGDYCLDGEDLGRMAAQLVLNELHRVQRVVNQLSDKLKAYGGEVRGMDTVKSGTEGRQNFLSDSETNSPFSVLMLDQLETDIRKRLTALSLNIIDMLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Y3</accession>
    <name>A0A194X0Y3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_159243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067877.1">
        <property type="nucleotide sequence ID" value="XM_018205484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Y3"/>
    <dbReference type="GeneID" id="28815210"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_159243"/>
    <dbReference type="InParanoid" id="A0A194X0Y3"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267697" description="alpha-galactosidase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="286"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="390" mass="42225" checksum="6EFB5F4ADB78E2B1" modified="2016-10-05" version="1">MFFWIVWAWAFATAAFGADYKVGQKFQIVLSNVVVAPSNPSTKIIPADAEVFDIDMFETEASTIALLQAQGKIVLCYFSAGTYEPYRPDSGQFQASDKGKALPEWPDEYWLKVTSTNVRNIMTARIQLAASKGCNGIDPDNTDAYANPTGNTTVTMAEAIDYIKFLGGIATGLNMTIGLKNSLQILSDVSDTISFAVNEECGFYQECYWYKDFIASKPVYQIEYPTPLPPSASVRTSSCAVNPTQPAGLSLVFKNLSLDGYVSYCDGSSDTTDTKPGDANAPPPRSSKTTVHPHPSTTSSRPTSSKPSQTRSSTTSRPTSSRPPQTTPSYSSRTTSSAMPSSPYPSQTNQPGGCIAKHWDQCGGQNWKGCTVCASGFTCKFSNPYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1E7</accession>
    <name>A0A194X1E7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_672285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068375.1">
        <property type="nucleotide sequence ID" value="XM_018213277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1E7"/>
    <dbReference type="GeneID" id="28823003"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672285"/>
    <dbReference type="InParanoid" id="A0A194X1E7"/>
    <dbReference type="OrthoDB" id="3543757at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF411">
        <property type="entry name" value="OS02G0248440 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="308" mass="34908" checksum="BE0EF7621164966C" modified="2016-10-05" version="1">MAILHQVSFYNECGHIEDCIRASDLLETLNVAAVEEGVAMLPSLDFARAMLDPGNSVFTTEVYYKTSKCGRCEGALPAGPGRSETVGELTESAIKDRRMLWKSITDNLVAPQAILKERHKALLECIRGTLLSSSDPNAPATFDIWSKNLSRSIERERRWYQDFVLLHFRELQLGFPLLQRTHAYAPGWRSELFAAVDNWTIDKDEVCSICQLPSGVPNVRVSQLPCKHQFHFSCIDQWMGAHGTCPMCRTMFNILYPPRPTNVFPEIRDGLEQLTAEQTHKGYYHLGAALEPVLLTERFLDGWNTFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1W9</accession>
    <name>A0A194X1W9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068548.1">
        <property type="nucleotide sequence ID" value="XM_018213224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1W9"/>
    <dbReference type="GeneID" id="28822950"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671564"/>
    <dbReference type="InParanoid" id="A0A194X1W9"/>
    <dbReference type="OrthoDB" id="5409006at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17358" checksum="B040E89016D13F4B" modified="2016-10-05" version="1">MSRHFSSAVRAAARIIWSFNGTTKSLERDVAAVEQAVGANPELAKKVKNGLINGDPHSTKYADGTEDPVHISGVLGEGNLKGSKKATSFHYYPDTGDIRFSNSRYPPVRIGTSNAVAESSSSAQSGAKIPAHQQASDWEWDGSAQKYKYWDGTQWVWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2D2</accession>
    <name>A0A194X2D2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_590036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068524.1">
        <property type="nucleotide sequence ID" value="XM_018209571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2D2"/>
    <dbReference type="STRING" id="149040.A0A194X2D2"/>
    <dbReference type="GeneID" id="28819297"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590036"/>
    <dbReference type="InParanoid" id="A0A194X2D2"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF57">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="42992" checksum="0595B2BC1BD1C5AD" modified="2016-10-05" version="1">MSYKPAICSMSLGRAWVHQITPKFTAAASAGLPGIEIFYEDLLYLASSYPGGATSANQLLAAHSIKSLCNSLKLEIIGIGPFNNCEGLLCPILKAQKRQELELWFQVAHILNTDIIQIPCTFLPESDERITGDLEIVARDLREIADLGARQNPPFRFAFENLCWGTYNDTWAKAWAVVEAVDRPNFGLCLDTFNIAGREFADPTREDGMVVNAKESFRESIKRMARTIDVEKVFYVQVVDAERLERKMDERNEFWVEGQRPRMSWSRNCRLFLCEEERGGYLPVMDVLNAICGSKEEGGMGYKGWVSMELFNRTLVDEREEIPMEHAVRAMESWKKIVERMGWEDIIEKVKQRKQIVSRRPVVENVPERVEISARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2Q7</accession>
    <name>A0A194X2Q7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_671807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068820.1">
        <property type="nucleotide sequence ID" value="XM_018213240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2Q7"/>
    <dbReference type="GeneID" id="28822966"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671807"/>
    <dbReference type="InParanoid" id="A0A194X2Q7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267760" evidence="2">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="11618" checksum="C2DC4540F1853594" modified="2016-10-05" version="1">MMLLKYITLLLFLIALSATTPTNTLPTLTSTTTTSASQTPTVTENSYFRWSMCVPSKECNDPLDIVIGVIIFLVLSVGSTTFMVCSVLYRCEERRARLRARSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X301</accession>
    <name>A0A194X301_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_621109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068920.1">
        <property type="nucleotide sequence ID" value="XM_018210935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X301"/>
    <dbReference type="STRING" id="149040.A0A194X301"/>
    <dbReference type="GeneID" id="28820661"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_621109"/>
    <dbReference type="InParanoid" id="A0A194X301"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267851" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="159"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="41136" checksum="CA2425FD217895B9" modified="2016-10-05" version="1">MHFCFLAVIQLSIFALEGLTSPDSRHKHVVQDVGIVSSTSSSLTSKSSSSSIRITVTSILKSTSVTLKSTASTSESTIPSLKSTSLSSKSSSLSSKTASLSFQPTTSTAKSTTLTLKSSSSTVQTSIVVPLIKSISSSTSALLINLTPTSPANSGKRGIPYNSPATNIQHFNASGSKVTWAFNWDSLMDTDFPSYLEFVPMLWGNSSVHTTNWKKNVQNALSRGSKAVLAFNEPDACGGGQSCLTPQAAANAYLTYVQPFAGQVKLGGPAVTEVGTAWLLEFLALCANCTIDFIPMHIYNSATNIAYYQAHMKDIANQTGWPIWLTEFSATGNQTVFLQTLMPWMDAQPFIQRYAWFMCSPGYSGSTCGADGYPTALGQVYELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3I8</accession>
    <name>A0A194X3I8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_687027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068949.1">
        <property type="nucleotide sequence ID" value="XM_018215409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3I8"/>
    <dbReference type="GeneID" id="28825135"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687027"/>
    <dbReference type="InParanoid" id="A0A194X3I8"/>
    <dbReference type="OrthoDB" id="10650415at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="28638" checksum="718296D3267EF2FC" modified="2016-10-05" version="1">MEHKEGKRAQEQESAMKISMSKMLMCRLRSFVCRRSFSATPLSLPLPLDTATCRARALWAGRFRMKKESLGNQFNIFLFKTKTHVDSVQQKFRARMQLNAHVLLAQQFCQFSGKLCTMLDSIRSEDPAFTPYIHPLYGVVEILNCYYSDTSEVDEHLCTQWFGDQRYSKLFQQWQDLRKGVKQRAQSLEAFLSPDRPRLMADDGKVPLESLLELSIQCYLDWVPNRQPKQYDIGTDIPHLSFVFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X414</accession>
    <name>A0A194X414_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_671327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069285.1">
        <property type="nucleotide sequence ID" value="XM_018213211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X414"/>
    <dbReference type="GeneID" id="28822937"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671327"/>
    <dbReference type="InParanoid" id="A0A194X414"/>
    <dbReference type="OrthoDB" id="3537340at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="29700" checksum="57683119934D3F71" modified="2016-10-05" version="1">MTGQFTEKDPQRCAHYARFMSHLTLAEANSIFWLLFITVLILMCISSLQHHKSNAIAERDKALPKKVTSSTSHQLKNRRLRLHYLSIASLCLVLAATATVFECFALFNIEFCDGEDLMQIYWGFWSVLQVGSNIAILGVMVQFWIVLGDIETPSWAVALGTPVLVFAAIGFGGRHVFKETVGRIRRKRQGVGDEEMGRRSDNEEDQLRDDDVVGPRDEIVPEKYNGDRSLSTASTTIAKQQRVSLSAFDWRYQCWSAQHVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X424</accession>
    <name>A0A194X424_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative gibberellin 3-beta hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_735975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069271.1">
        <property type="nucleotide sequence ID" value="XM_018220070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X424"/>
    <dbReference type="STRING" id="149040.A0A194X424"/>
    <dbReference type="GeneID" id="28829796"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735975"/>
    <dbReference type="InParanoid" id="A0A194X424"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="215"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="42406" checksum="EDA7127CEF8A7C60" modified="2016-10-05" version="1">MSTTVTETVREEPQYEYYYCDHSWNNKREILRGEKAVETFDEIPLIDVERIFSEKYEERLQLATEVADVCKTVGFMYIKNHGISQELIDDVFKLSRTYHDQPLEKKKEEYVYKSETLRGYDIHYTKTPSGPAVKKESFMYSYNPDNDPQLPNLTPEQREQCIGLHNMWPDHIPGFEPRLVEYFAELLKLSRRLMRTFALGLGAEETYFDSIVTAPYVSIILQHYPPRALGAADLDGLGAHSDFETFTILNQDMVGGLEILNKNGFYIPAKPIRGTFVVNIGDFLQRISNDIFVSTVHRVRNTSGLERYSIPFFLSFNVDAEVSVLPTCVSESNPARYGPRNLHEYTARRRQLQKEAHEKGELEDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X507</accession>
    <name>A0A194X507_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_750591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069621.1">
        <property type="nucleotide sequence ID" value="XM_018221206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X507"/>
    <dbReference type="GeneID" id="28830932"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_750591"/>
    <dbReference type="InParanoid" id="A0A194X507"/>
    <dbReference type="OrthoDB" id="4586224at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="396" mass="44988" checksum="14E336116C7C4AB0" modified="2016-10-05" version="1">MGRRPPRRDYFPPVFLAINTTHFEILPFSYKSEDLAFSDWITLFTLCLAPLIAHILSGAPKVVYFAKRRPSWHERIGVYNPTTILWRYFAIADRRIRAKHWSAVDVAAANVNFWTSRGWDGSEALSRNSREYCVSRADSKHARLLSVGALETLIVTLQGVNALYTLTSSIVPSQYWNSANFSNTLSIGTIFFPLSVFGLLRLFAAFWLTDDSIYTNYEDFQTMQMSQDRESLQDGVQLLEIPELSTSRLPENSDATSENDYHAPNCWQSLLFRVSFLVPIVGLIVICLYYTVPTSIDDNVSLETVTGFILVLFYLIIFVVTLFIYGYYFFRDQNITTVIPCISALWYQIYTGILIGMVVVLIIVASLETRQSQCGYFTSWPSDTGTVTHRSISGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X545</accession>
    <name>A0A194X545_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069549.1">
        <property type="nucleotide sequence ID" value="XM_018222676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X545"/>
    <dbReference type="STRING" id="149040.A0A194X545"/>
    <dbReference type="GeneID" id="28832402"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783392"/>
    <dbReference type="InParanoid" id="A0A194X545"/>
    <dbReference type="OrthoDB" id="3903561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="389" mass="44212" checksum="912451E9A652A1EF" modified="2016-10-05" version="1">MSMLVLIANGTEGIALDATYCTIGSGSSELYSDDNFSTILNIDTVFGKLSFGMAKFIDLTWDIGFSRCGQAMLAWIAYRVHTAALFRIMETQSVSYELFISLSLSLPSLVCLGSTTKSLFAKLGFRNRLALFWIVLSIIWVALWPTITNAMTGYVAESNTLVKLKTGEGYVDISNITSPSNLAFQVNYLNRTLVSIVLETGPNITLWNYFNQIYRAEDFYEPIYYQDVVAYPVYIFQNQSYNPQMWFNIPENVQCVATGVYQWGFSSSIVFAFTIINFLWFLGTYAVWTLMNRKSELCRKGRRLGQYRAMLDVVECIQEDLGMNICAYSEQELQEELKKKGGIKYYVEYGGDDSSHIGITSAKDKDPLRPRFGETYGQLRIRKSRNLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5E0</accession>
    <name>A0A194X5E0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_783548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069745.1">
        <property type="nucleotide sequence ID" value="XM_018222693.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X5E0">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X5E0"/>
    <dbReference type="GeneID" id="28832419"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783548"/>
    <dbReference type="InParanoid" id="A0A194X5E0"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="47"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="703"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1480"/>
            <end position="1850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1856" mass="205929" checksum="1DF4AC1C8F7E2170" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5S9</accession>
    <name>A0A194X5S9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_619523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069891.1">
        <property type="nucleotide sequence ID" value="XM_018210882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5S9"/>
    <dbReference type="STRING" id="149040.A0A194X5S9"/>
    <dbReference type="GeneID" id="28820608"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_619523"/>
    <dbReference type="InParanoid" id="A0A194X5S9"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="350" mass="36766" checksum="86E4922CEDCD2A5A" modified="2016-10-05" version="1">MAAQCPITTPLTKLLNIKHPILLAGMARTSGGPLAAAVSNAGGLGCIGGLGYTPTQLREIIHELKANLSSPSLSFGVDLALPKVGEGARKTNHDYTHGQLDDLITVTIEEGAKLFISAVGIPPPHVVKRLHDAGILVMNMVGAPKHAKKALDAGVDIVCAQGGEGGGHTGDVPNSILIPAVVDVAKQYKPKLLGGQTALVVAAGGIYNGRSLASSLMQGATGVWVGTRFVASTEAGCSQAHKESVVTANFEDTLRTLVVSGRPLRVRRNEWVDKWEAEPEKIKELTEKGVVPIEFDMEAGNDVEIPFLMGVVAGVIKDIQPAKQIVDEMVSEAVEMLKQGQTFLGGRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5T1</accession>
    <name>A0A194X5T1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_670906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069789.1">
        <property type="nucleotide sequence ID" value="XM_018213195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5T1"/>
    <dbReference type="GeneID" id="28822921"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670906"/>
    <dbReference type="InParanoid" id="A0A194X5T1"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="345" mass="40046" checksum="60E74574B82D707B" modified="2016-10-05" version="1">MSSQELLHEPPSISPEEFEFGRLKPLSHSAESISKAIIQFNKRETYSVYSMAEDPCPRRRMGAENFKHHGTWNLGNPHNLEDIKKYFGYFNDVYFNGLLTGYCTLELVDGGAMKRRYGSDCGGRCQPYFPGEEIDSRHKATKPQIIITIRSLANYRDKYAAIKEYHLVILHEMLHAMFDIFECRCYRGCLDRTNREASGGHHIAWQAAAKALERGVWLGANPFDLYFDLRREVCLAADMMLGNKLPNEATLRILRLDIELILKSLKEQRAEENQDLKERSAWSRLIRASNSCISKQQTVDAWDRNFGFERDKWPYRSHCMERGERDLWGMPSSTISANELWQFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6N3</accession>
    <name>A0A194X6N3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_97094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070183.1">
        <property type="nucleotide sequence ID" value="XM_018223542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6N3"/>
    <dbReference type="STRING" id="149040.A0A194X6N3"/>
    <dbReference type="GeneID" id="28833268"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_97094"/>
    <dbReference type="InParanoid" id="A0A194X6N3"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040090">
        <property type="entry name" value="TXNDC16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22699">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22699:SF1">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267895" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="38722" checksum="8A1F0B6D737535D8" modified="2016-10-05" version="1">MLPRNLLICILDLIAARTAFGWNHVSKSQFQSLTRETSITLVAFVNPETEASKALEAEWISATSQTNQHLLSIDCKAEADLCAEYDVVSFPAIRLLKGSESSMRYKGPRKSSEIIPFLHRAVAPTVSLVNQKNITTFTSSDETVFIAYTTPEDHHLQSTFAALASKNHDKYAFGIATDKNLANSAGITLPSIVCLRPGEGEQEVLSGEAGIDAIEKFIETATAPTIGEFTRRNEMKYMKAGKSLVYFFAKTEAERDAYKAPLKPVAKKYKEYLSFVTVDAVEYGHMLPALGHAKGSSPVVSVFNPMYGQVFPFAKGKKITAESVEGFVMDIVQGKVQPSVPGQERVGIVHDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6Y1</accession>
    <name>A0A194X6Y1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_561719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070199.1">
        <property type="nucleotide sequence ID" value="XM_018208467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6Y1"/>
    <dbReference type="GeneID" id="28818193"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_561719"/>
    <dbReference type="InParanoid" id="A0A194X6Y1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="21971" checksum="08D7CA17D83D1F9D" modified="2016-10-05" version="1" fragment="single">LSRLPLWLSRWLGYRASAPKPEPQLVVYFWSFIASFCTISILQAIFSYASYFRARHVPAVIGSYGASAVLCFDVIGVPFAQPRALVGGHFISALVGICVTRLIEVRHDGQLLWLAGSLSTALAIVAMRFTKTTHPPAGATALLAAVDPNIHALGWYYLPVILLSSIVMLVMALFFNNIQRRYPSFWISPPTLPTPTPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X704</accession>
    <name>A0A194X704_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_783196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070310.1">
        <property type="nucleotide sequence ID" value="XM_018222655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X704"/>
    <dbReference type="GeneID" id="28832381"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783196"/>
    <dbReference type="InParanoid" id="A0A194X704"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="198" mass="22280" checksum="3AB83B3DAEC2A43A" modified="2016-10-05" version="1">MATLMEPRALMASICQMLSNCSTDLQSLESEFGPLPSLFVNPGGRRKTGQVHEAKCLRDALDREVERMKWLQFDLLEPGGNKLHLVPDDQRNLAIDGLYNALNYLKSRICVVIQDYKKRADSQLGAKAFRHADMAALYRNMNHFLHSAMAQAGRAAKILRHSPACTWSKHQCHEVSHNLGVDSLKLIPPDAHPPHVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7J9</accession>
    <name>A0A194X7J9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_95884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070137.1">
        <property type="nucleotide sequence ID" value="XM_018223533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7J9"/>
    <dbReference type="GeneID" id="28833259"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_95884"/>
    <dbReference type="InParanoid" id="A0A194X7J9"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="654" mass="72945" checksum="BE83F09F2205BF33" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7R4</accession>
    <name>A0A194X7R4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_77292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070563.1">
        <property type="nucleotide sequence ID" value="XM_018221918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7R4"/>
    <dbReference type="STRING" id="149040.A0A194X7R4"/>
    <dbReference type="GeneID" id="28831644"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_77292"/>
    <dbReference type="InParanoid" id="A0A194X7R4"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34130" checksum="EAF201C80C6B73EB" modified="2016-10-05" version="1">MSSAKEKANLARIRDNQRRSRARRKEYLQELEARLRQCELQGIEASSEIQMAARRVADENKKLRGLLAQHGVADDNIEAYLQTSPTTDGMAGGPYTSSSGAVQLLEQLLQTRKTCCADGNNPVLGQGTGSRDSSTSVTTVQSLWDPVYAQNPGRAGSLQQTGKAASSAHQFMTPSTSSASRTSSVSHGPASHHQRLALGQIPRSPASNPSSHSQHQHLFDFDPQISVSGSYSSHQSHTHKHLQPHSGAQRSSVYISHPPTNTNVNNCNYAAEMITTMAGADPSTVRADLGCLPGMECDVDNHHLFEVMDRYSGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X802</accession>
    <name>A0A194X802_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070650.1">
        <property type="nucleotide sequence ID" value="XM_018213129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X802"/>
    <dbReference type="GeneID" id="28822855"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669824"/>
    <dbReference type="InParanoid" id="A0A194X802"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267935" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="12083" checksum="30C00C066C71BA01" modified="2016-10-05" version="1">MKLITSIVFVALALLSILSSTAAAPRPPVPAGPLINELVSRQSNSGGFVSGSDVSNSLCAGGSVNSSGQCICSARCVQVTRACTEPNGHCTPTLQSSDASSRNSAELFGLAVACAAVVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X872</accession>
    <name>A0A194X872_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070725.1">
        <property type="nucleotide sequence ID" value="XM_018215068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X872"/>
    <dbReference type="FunCoup" id="A0A194X872">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X872"/>
    <dbReference type="GeneID" id="28824794"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685364"/>
    <dbReference type="InParanoid" id="A0A194X872"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="27914" checksum="C9D033F9BB34E0C2" modified="2016-10-05" version="1">MLTTIWRAQALFLPEASDYISHSLAETLSLVRPIEDSIYVKGLQKEAKDNKLAINAGIHEPGDDKKSGKIKNTSIWISEDGEIIERYKKLHLFDMNLTNGPQAHESDVFEEGMEIVPPLQTPVGLVGLLICFDLRFPEVPLSLKRQGAQIITYPSAFTVPTGKAHWEILLRARAIETQSYVVAAAQAGHHNEQRVTYGHSLIIGPWGDILAELGGEFNGPEIATATIDLTVVNKLRQEVPLKRRTDVYPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8H9</accession>
    <name>A0A194X8H9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_782722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070825.1">
        <property type="nucleotide sequence ID" value="XM_018222614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8H9"/>
    <dbReference type="GeneID" id="28832340"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782722"/>
    <dbReference type="InParanoid" id="A0A194X8H9"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="538" mass="58086" checksum="43734A5149434F82" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X938</accession>
    <name>A0A194X938_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_669830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070657.1">
        <property type="nucleotide sequence ID" value="XM_018213130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X938"/>
    <dbReference type="GeneID" id="28822856"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669830"/>
    <dbReference type="InParanoid" id="A0A194X938"/>
    <dbReference type="OrthoDB" id="5226159at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13212" checksum="68686B6929333EE7" modified="2016-10-05" version="1">MLPCSNISDNICKIGNRCLESLGFKSKPRPKLEISSPFNFKEGPAIHFPGYSEDDISLMREKAIASTAIVEAEDGDLEQFEQYDLSRRDGARSRASSYSCGFGGRVISHARRVSRGRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9U8</accession>
    <name>A0A194X9U8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_553204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071298.1">
        <property type="nucleotide sequence ID" value="XM_018208329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9U8"/>
    <dbReference type="STRING" id="149040.A0A194X9U8"/>
    <dbReference type="GeneID" id="28818055"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_553204"/>
    <dbReference type="InParanoid" id="A0A194X9U8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="8261" checksum="D50C16B68F50E81A" modified="2016-10-05" version="1" fragment="single">ESLLCSGQTILITPNLLSALARLHDDIKTTPIWIDALCIHQESATERSAQVARMDSIYRSAQKVIIWLGPEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA76</accession>
    <name>A0A194XA76_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_747795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071022.1">
        <property type="nucleotide sequence ID" value="XM_018221136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA76"/>
    <dbReference type="STRING" id="149040.A0A194XA76"/>
    <dbReference type="GeneID" id="28830862"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_747795"/>
    <dbReference type="InParanoid" id="A0A194XA76"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="5">
        <location>
            <begin position="200"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="451" mass="51128" checksum="79F3717D39716A53" modified="2016-10-05" version="1">MSTGDSPQDTETQRVSGSLVTGFQVSSSSEALTVDFLDTTFTFHAQWLHDAQVDAGPSKDAIDVFTQKGAVARIRNTKLSGQELRSSLDVTWDDGSTSCFPTIWLRAFAPLVAKPHDSEQKTPFEASRGWLPTTLKILEFSYKDIFPKDPYSDTSNATKEQIYDAILKKSSAGIVKVIDLPEPNLEDERQKENTFVMRVLKQLFGSVFLHPIRGTEKTFNISSHHEEDAKRGANLPNYNAIKALLPHADHAHYIHPSRVQGLYALEGESQNTFVSCYAALETLNSEAPELVKYLKSVPMVIGRVADFYDPPLYQATVDTAITMEPGMPDHVKRFRWHPHLAGSLLSPYDTFAEARTAYRAFQEIMRRDTHQLNVLFKPGDLYIWDNFRILHGRERILTTPRTVVGQTVPEQVVDDAYRVLKMRRLKGFMDEKWLVHTPLQQLEEMVRLAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBL5</accession>
    <name>A0A194XBL5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_668872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071915.1">
        <property type="nucleotide sequence ID" value="XM_018213057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBL5"/>
    <dbReference type="STRING" id="149040.A0A194XBL5"/>
    <dbReference type="GeneID" id="28822783"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668872"/>
    <dbReference type="InParanoid" id="A0A194XBL5"/>
    <dbReference type="OrthoDB" id="5243686at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="37485" checksum="F001890A86C91705" modified="2016-10-05" version="1">MQDVFQIRPFQWRGCFFANTSNTTKIKQKSKRKHSKADSYNSLPPQPELSEAYEEESVEETWPPPSFLFTINELPVNDEPTQRTIELLVPLADLELLLQGGEPPRVDEYGNWHPPIRSNGFGTQVPSRIYRWADGGRVSAARECQWFNNQWWSQAGNELTEYRASTMFWCNNFTQFLVATGDASRRHMEQSIDPHNRWWPLTFRHESTLSRVEEVGQEGRLAGSGTWINALGLTSYRNRHTVPAGGLAGNLAIMIGLIAFSCESTDLDTVLLTDRAWRRGRWHDHGRIDGRIDERGVVVTIYHDPENTQGSTNDTIFPLEWTGAALLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCK7</accession>
    <name>A0A194XCK7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_643717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072249.1">
        <property type="nucleotide sequence ID" value="XM_018211807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCK7"/>
    <dbReference type="GeneID" id="28821533"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643717"/>
    <dbReference type="InParanoid" id="A0A194XCK7"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF18">
        <property type="entry name" value="NICOTINATE CATABOLISM CLUSTER-SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="931" mass="104138" checksum="69B833A3AA9FA780" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XET2</accession>
    <name>A0A194XET2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_683567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073011.1">
        <property type="nucleotide sequence ID" value="XM_018214725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XET2"/>
    <dbReference type="STRING" id="149040.A0A194XET2"/>
    <dbReference type="GeneID" id="28824451"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683567"/>
    <dbReference type="InParanoid" id="A0A194XET2"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
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        <location>
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            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="288"/>
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    </feature>
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        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42178" checksum="29D0D9DFCD2B2087" modified="2016-10-05" version="1">MTMLLKFGEEDELHKARLLNVEEKPFKRITKRLLAPGSLLNNPLKLPTPPPETGSAEDTSEDDPTLKQQAEERQQLRQEIIFDFDAFDSSIARIQFLRNSNENERDRYTADKQRILDTMQEVRVSTAQLRIQLEESKKTLEQRKKFDELAEKITGNRLLRPREDQEVNLRKLEEECRELEKESLTYGETWKERREQFGKIVEEGMQLRRLIRDEKEEVERREGMDGGEEDGEVGEGSRGGQTPKHSSFSGNATPRPDGESQSMSGSGLKPRPLNSGTFSRPGSTTGSRAASPAGSEREREELVEGEDSMILDDGPKVEESDIVAATPLADTVDMAIVSTPQVVVDEPSPMVAVEGVEPSEEEGEEGEAEDKMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF27</accession>
    <name>A0A194XF27_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_696219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
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    </dbReference>
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    </dbReference>
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            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="29254" checksum="6B7AA79911F7FE2C" modified="2016-10-05" version="1">MRLIETSTFELSEFIGSHIPFYAILSHRLRGCCAQAAKDGFQWVWIDSCCIDKSSSAELSEAINSMFKWYEGAQVCYAYLYDVTSSIDNLSNVYAEFRRSEWFTRGWTLQELLAPQCVEFYNRDWVEIGTKSSLAEMIKKITGINRLFNYELACVAQKMSWMARRETTREEDIAYCLMGLFGVNMPTLYGEGSKAFLRLQQEILSKSEDESIFAWEGPLGEFHESGLLAHSPKWFGDCAHRRRVLETNLNLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF42</accession>
    <name>A0A194XF42_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_505370</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF42"/>
    <dbReference type="GeneID" id="28817738"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_505370"/>
    <dbReference type="InParanoid" id="A0A194XF42"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="761" mass="84563" checksum="C0FE5586FECB3D03" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF51</accession>
    <name>A0A194XF51_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_504599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073131.1">
        <property type="nucleotide sequence ID" value="XM_018208001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF51"/>
    <dbReference type="GeneID" id="28817727"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_504599"/>
    <dbReference type="InParanoid" id="A0A194XF51"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="27923" checksum="E1DC5CC95C6F81A4" modified="2016-10-05" version="1">MTFDPKQIKGLFFDIYATLISWEDGLYTHLLHLTKQPGSPEIRSRLLRMNAAIEKAVEHEHPDWKYPLILEEVYARIAKELGLQFDRDEQISYGRQIGDWPAFPDTVAAMEILAKHYKLFVLSNVDEDSFGRTCAGPLKGVHWDGIYTAEQIGSYKPDPRNYEYVVDRFQEIGISKGEVVMVAQSLDIDHVTCTALGFKPGVWIERKGAIMGGNRKELEDQGLLELGAVYASLGDFATVVEKAFAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF66</accession>
    <name>A0A194XF66_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_583508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072767.1">
        <property type="nucleotide sequence ID" value="XM_018209216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF66"/>
    <dbReference type="FunCoup" id="A0A194XF66">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XF66"/>
    <dbReference type="GeneID" id="28818942"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583508"/>
    <dbReference type="InParanoid" id="A0A194XF66"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25830" checksum="CC0929EED07C5562" modified="2016-10-05" version="1">MSTLSPSSQATPTKPSLPIDLLPIDLARLVSQAHPALLLAAYYIRFPVLVADPVSTLLQTLLPVAAIQVVYAVICLPAVGSNAKPALVKKAKLNASKKGAEPSQVTGKAFTAIFSLLLSLLTTLPLFALQILFGAPVTSHLPHTALSSAHISLLALFPLFYVHGTSASKWREIVSIYSPIDEVFGGSLGALLGAWLGAVPIPLDWDRAWQAWPITVVTGAYIGYGVGKMVGGWLLRGKRVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG92</accession>
    <name>A0A194XG92_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_773299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073543.1">
        <property type="nucleotide sequence ID" value="XM_018221931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG92"/>
    <dbReference type="GeneID" id="28831657"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773299"/>
    <dbReference type="InParanoid" id="A0A194XG92"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="214" mass="24731" checksum="A60E613E60587C2C" modified="2016-10-05" version="1">MPSIIEHAPRFDRSKQPTSLQIPDQFKCPNHDPAKYVPRSLSVLRLLALLPYPFDNVKSEVLVELWFIADFAQTPKLQTEVVNALEEARVQYERSIPTSKLVRIYKKTREGSSLRKYTVEALVARNKIEPENYHQQLTIDLVKAFSIESTSLRTAIQTLVPAKFRFRFDVDMKKCQMEQISKQPTSPPTHQQRSTKRSRASNHSSNARRRGIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH11</accession>
    <name>A0A194XH11_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073850.1">
        <property type="nucleotide sequence ID" value="XM_018214682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH11"/>
    <dbReference type="GeneID" id="28824408"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683316"/>
    <dbReference type="InParanoid" id="A0A194XH11"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="23251" checksum="F146B45DDCE3EE9D" modified="2016-10-05" version="1" fragment="single">MHYENGYGLNQYEQSQHGQNSIYHNSWYSSNSGIENGHQQLQSQNPSQQPTVMSQHHENEAPPPYSLEAEAAATTLMQLIQASQESRSPTIFEPQPQRPQVWDGVHESFQCQADSSLPPPPDSLDENLDKEIERWTREPLEDVRYMEPPEVALRDSRRIEFDRTMRRVREEIQANRRSVELHRRRQNGQVDIMRVDSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHR4</accession>
    <name>A0A194XHR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trafficking protein-like protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_695896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28826517"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695896"/>
    <dbReference type="InParanoid" id="A0A194XHR4"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18453" checksum="D0DDAB6E0DEC4250" modified="2016-10-05" version="1">MSYYFAIIGTKDNPLFEYEFGTAKQGGDGIARFAEQARHMNQFIVHSSLDIVEEVQWGNGQMYLKCIDRFYNNYVSCFMTGGNVKFLLLHSPSQPATTNTSRASTSIGANPTSPQTEEAIKQFFTEVYENWVKTIMNPFYNVNAEVRSPVFRSRVAAAGKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XII3</accession>
    <name>A0A194XII3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_494575</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073932.1">
        <property type="nucleotide sequence ID" value="XM_018207921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XII3"/>
    <dbReference type="SMR" id="A0A194XII3"/>
    <dbReference type="GeneID" id="28817647"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_494575"/>
    <dbReference type="InParanoid" id="A0A194XII3"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268315" description="laccase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="205"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="424"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ19577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="593" mass="66056" checksum="81492EDE5151F1E8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ26</accession>
    <name>A0A194XJ26_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_682914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074481.1">
        <property type="nucleotide sequence ID" value="XM_018214599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ26"/>
    <dbReference type="SMR" id="A0A194XJ26"/>
    <dbReference type="FunCoup" id="A0A194XJ26">
        <property type="interactions" value="1308"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJ26"/>
    <dbReference type="GeneID" id="28824325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682914"/>
    <dbReference type="InParanoid" id="A0A194XJ26"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ20126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="375" mass="41639" checksum="5BEC2EB2E906A066" modified="2016-10-05" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFSLPHAIARVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ92</accession>
    <name>A0A194XJ92_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_639737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074670.1">
        <property type="nucleotide sequence ID" value="XM_018211633.1"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <strain evidence="3 4">CBS 120377</strain>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="KUJ20321.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_666855"/>
    <dbReference type="InParanoid" id="A0A194XJS4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="32259" checksum="A0C299FD7D5C8350" modified="2016-10-05" version="1">MVVFRKVSRMQLAKARRAGSLIYWLGDAIRRSNRLLEAAAAAVGAGFLCIRRVEKRQFPDPCAGSRPATLHRLFPDQTRDLFADRASASAVPSPSSTLADHHRMRGEAAYLKTKCDEMKSVVRRWISQMLLKQSGAAPLPGAKSLVVSSTALPRILQDRCIYTPEYAATAFIHLDQSFVHYPLTHDGGGFHSQLIQLELCLSAGGSSSDIKSFVVWLSAAPAPALFLKDLAAIVVVLRACFVPRKALRRVLSSSNARSIVGSASPQQPSKTSLCALCFCCTAPAYSENSIDRFPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJY2</accession>
    <name>A0A194XJY2_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_578802</name>
    </gene>
    <organism evidence="6 7">
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the Diels-Alderase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJY2"/>
    <dbReference type="GeneID" id="28818693"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578802"/>
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    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22903">
        <property type="entry name" value="DA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268327" evidence="3">
        <location>
            <begin position="22"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase C-terminal" evidence="4">
        <location>
            <begin position="251"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="429" mass="48068" checksum="CC6F122DD864AF10" modified="2016-10-05" version="1">MSNFFTVTALFSAVAVAFVSQVPLTPPFPDRLNEEWDDSCSISKSTAFEVYDGLITFSTSQSDHINSVKILPAVNSTNWEQWEFDGLSHTGLSGLLMAFSRDPSYAFFGQGNLRVEFYITLGDGTVIQELDYLKESYIIDCPDFTAGVWNSSDRSYSFHVTKDLKYAKLKFDSWRVRGGFTMSSSTPPHNADGSPWIPEGGNAKATELSPGMFYALPMGGAAVEVDATLGSGRRIVFSGRGGSTRLWATEGWLKICDGWKVIRAWAGPYSLVYWDLVSRMDWGVKYVSAHLFYDDQLVVGTNVGNVSETEDYVLATDRFDGELHGRYKDKNTGHIFEFVSPTQDRRWKFELEHMITQYEMGAGGGFGMTGFANRVTGGEVGEIQYEGRAQSEQTFWPEYIEEWKIWLVYGAGFLGKGKTQFMKLMGYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLS7</accession>
    <name>A0A194XLS7_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_609579</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075488.1">
        <property type="nucleotide sequence ID" value="XM_018210523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLS7"/>
    <dbReference type="FunCoup" id="A0A194XLS7">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLS7"/>
    <dbReference type="GeneID" id="28820249"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_609579"/>
    <dbReference type="InParanoid" id="A0A194XLS7"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ21133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="564" mass="64572" checksum="37BF662F7FBA3907" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM40</accession>
    <name>A0A194XM40_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_770453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075561.1">
        <property type="nucleotide sequence ID" value="XM_018221846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM40"/>
    <dbReference type="GeneID" id="28831572"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770453"/>
    <dbReference type="InParanoid" id="A0A194XM40"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="258" mass="29680" checksum="B8C59C4E2F33B332" modified="2016-10-05" version="1">MLDVVLDSKLKCKECRGPPEARCYTFKFAAAAIVAYRTIPSLLAIRRKNEEEGKRKKIKEEARRKRKEGEARRNVLRDRIKEEEVVAEACCLEQARRRKEEKERVEKIREEMKIKEQAMAEQAQILEEARRKNQEQEIAAPASYLDETKRDKEPKKPLGNIRVGIKEQAMAEQAQVLEEARGQKKERGLELELSYDLTAAAGKAQKDHKPEPNSTSSGDATPAPKEEEEEWEDISIDLADEMAELEMESRDLDGWVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM57</accession>
    <name>A0A194XM57_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_715435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075524.1">
        <property type="nucleotide sequence ID" value="XM_018218206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM57"/>
    <dbReference type="GeneID" id="28827932"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715435"/>
    <dbReference type="InParanoid" id="A0A194XM57"/>
    <dbReference type="OrthoDB" id="3557569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="159"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="387" mass="44573" checksum="26B4D82D1B85319F" modified="2016-10-05" version="1">MFFKSADLSQRQSLIMNPPNPDYSSMAFQGWRENGVLHLPDPSPSKVSPEPEIKYRLRRPRSRPSSSQSDQTKQSNKQLSRRRLETQSAPRLVLPRDYSMALMANRLPSLLEEWKRRSRSNQEQSQLLIEYTVNDALSTAINTTLSKELEKLSVHFVEFTLFMNLPPELRLKIWFYALPRERLVEVILDKLEPLELFSSSAVRSPTPVPAILQVCSESRVEALKHYSLMFSSRWGVRPARVYFDPSIDVLFMNCHRFPKLGFLDLLTLFDRTHRSITDMEKVAALCFCNGIAKRLGYLNRHGSLRTHFQIGLPLLERLIITEHGTQCLKQARLLPPSLEASPTFLEPRELDAFESIFGINAEFGIVKEEWSMDECESCAEVKDTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMP0</accession>
    <name>A0A194XMP0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_577473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075714.1">
        <property type="nucleotide sequence ID" value="XM_018208895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMP0"/>
    <dbReference type="STRING" id="149040.A0A194XMP0"/>
    <dbReference type="GeneID" id="28818621"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577473"/>
    <dbReference type="InParanoid" id="A0A194XMP0"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="564" mass="62869" checksum="3E9E04CBB412D080" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT1</accession>
    <name>A0A194XNT1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_767935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076124.1">
        <property type="nucleotide sequence ID" value="XM_018221768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNT1"/>
    <dbReference type="GeneID" id="28831494"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_767935"/>
    <dbReference type="InParanoid" id="A0A194XNT1"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24522" checksum="D8D609BDD471C4E9" modified="2016-10-05" version="1">MRSLGMRGKRTGARVALSVSGGPKGVYAGWNHLVNLVMFEGRRYLVDVGFGGNGPTAPLELRDGNVMQWGSTGDEVRLLWKGIGEFESPEEKCWVLEHRREGGEWEEVYCFTEVEFTEADVGVMNWKTARDLRGSFFNHIIICMRTEMEGEDVVGTVVLRDGVVKRVVRGESQTIRVCKSEVDRWEALEEHFGIVLGVQERNGIKGMVTELKGKPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP03</accession>
    <name>A0A194XP03_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_681202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076164.1">
        <property type="nucleotide sequence ID" value="XM_018214230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP03"/>
    <dbReference type="GeneID" id="28823956"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681202"/>
    <dbReference type="InParanoid" id="A0A194XP03"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="278" mass="29756" checksum="08A437C25E268E70" modified="2016-10-05" version="1">MPFTYPSPNAPSLSPPPRTIDGAGFGKVALITGCSSGVGLATTQAFLSHQYEVLGVDIHEVDYAQIAPRDAGRFHFHRGDLLSEGECDEVVRICVAKFGEKIDVLANIAGIMDAFEAADVITDHEWERVMGVNLTVPTRMIRAVLPFMKAKRNGSIINVASKAAVSGAAAGLAYTTSKHGLLGVTKHTAWRFHDEGIRCNAVLPGSIDTNINDSIEKEHFDDAAFAVMKPIWELHNPAGEKPSITAMEVANVILFLASEGARAINGVALPIDKAWGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPH2</accession>
    <name>A0A194XPH2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_393612</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076443.1">
        <property type="nucleotide sequence ID" value="XM_018207211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPH2"/>
    <dbReference type="FunCoup" id="A0A194XPH2">
        <property type="interactions" value="1334"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XPH2"/>
    <dbReference type="GeneID" id="28816937"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_393612"/>
    <dbReference type="InParanoid" id="A0A194XPH2"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="348"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="692"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="380"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="530"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="380"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ22088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="792" mass="85450" checksum="EC68A9D9DAA03B77" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR46</accession>
    <name>A0A194XR46_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_576071</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="KQ947407">
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        <property type="nucleotide sequence ID" value="XM_018208823.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:response to oxidative stress"/>
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    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="43"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <position position="93"/>
        </location>
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    <feature type="active site" evidence="11">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22202.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="743" mass="82462" checksum="8D24B1FB17B289A0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRI8</accession>
    <name>A0A194XRI8_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_680983</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04010)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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    </feature>
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            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="456"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="50459" checksum="216542C3DC23F9E4" modified="2016-10-05" version="1">MAELEKRDGMAEEKYMENVHEKNPTAAGQSNENAALTRKILFKLDLRILPILALLFLCSFLDRTNVGNAKTYGLEASLKMTDHQYDTGLAVFYATYIVSEIPSNLVLRKLSPKIWLPVLTIFWGIVTMCLGFVKNYSQFMAVRAILGICEGGLLPGMVLYLSGMYTRGEMALRLGLFYTAASLSGAFGGLLARGLTSIGKRGGQAEWSWIFIIEGLLTVAIGILAYFLLPNNVETAPFLKENEQIYARSRLHLDMPSRLAEDGSEHHHEAFRWSEVRRGIFNISTWLSACAYFGILAGLYSFGLFLPTIIVELGYTANEAQLWSVIPYAVASVVTVIIAIVSDRMKLRGVIMLFVLIPAIIGYAVIANISVAHPKVKYGMTFLMATGMYASVPCVLVWNSNNSAGHYKRATTTALQLMIANSGGFVATFIYPNKDKPQYHKGHTVVLGLLVMSWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRS0</accession>
    <name>A0A194XRS0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_607694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="581"/>
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            <end position="413"/>
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            <begin position="436"/>
            <end position="580"/>
        </location>
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        </source>
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            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22846.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="581" mass="61565" checksum="E1876F0DF77D3809" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <location>
            <begin position="36"/>
            <end position="55"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="57" mass="5946" checksum="C28D85E523E67CD6" modified="2016-10-05" version="1">MGKSFRSTEVLERIDSIFGGIAGTWMTGRSGTTSPVMSMGCIAFFVILSAPGPAFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mollisia</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22936.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="583" mass="62775" checksum="0C65DD44E9E4DE0F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT48"/>
    <dbReference type="FunCoup" id="A0A194XT48">
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    </dbReference>
    <dbReference type="GeneID" id="28815333"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_180559"/>
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    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="TLC-dom"/>
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        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
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    <proteinExistence type="predicted"/>
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        <location>
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        </location>
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        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="34383" checksum="8ABF54FE9D312704" modified="2016-10-05" version="1">MHDPFFVPASSFVFGETIKPLCDYLSLRSLPSHIHEILFAFGVYHLIFEYIAPPLSSLFLSHRYSKLSYESKLRWNMHCASMVSSCTICALALWTIVMDDERRNMNLIERLWGYTGAAALVQALATGYFLFDLVVMIRYLDVFGLGMLVHASSCLITYTLGFRPIFNYYGCVFMLYELSTPFLNIHWFFDKLGMTGTKAQLYNGIALLVVFFCCRLVWGAYSSFNIYRDVWNALHLTEAAKMGSNNDEMMRFAGDRSLPMWLVVLYMSGHVTLQALNVFWFGKMIAAVKKRFVKTEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTX1</accession>
    <name>A0A194XTX1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_662572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078125.1">
        <property type="nucleotide sequence ID" value="XM_018212654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTX1"/>
    <dbReference type="GeneID" id="28822380"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662572"/>
    <dbReference type="InParanoid" id="A0A194XTX1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="290" mass="29894" checksum="262D0EE93C7CDBA8" modified="2016-10-05" version="1">MSEDKKFIISDASPKEIPDLTLPPCISPVRKSSGSEPGHRDVEHVGRGPENTSNDGTTQPTNSLEESSQDHGIESTYLNTEPDPRSVATIPNSRAASEHPDATGQPSSAASSSASVTIPNIQTITLRPTPTPPLREQLVRNVPTCPPCHANPGNSNCRGSPAFAQCRGEAPVPDGSQFAIHSVGIGGSGVGVVAGSIVGAVGGDVSGSGSCRLGENSNEGGSAENVGGDGFDATDQREEPKDGTAGSRSKKADENGSNGEKTERAGGDESVPDWGRKGKERWSMQFAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVP7</accession>
    <name>A0A194XVP7_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_572138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078760.1">
        <property type="nucleotide sequence ID" value="XM_018208625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVP7"/>
    <dbReference type="GeneID" id="28818351"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572138"/>
    <dbReference type="InParanoid" id="A0A194XVP7"/>
    <dbReference type="OrthoDB" id="4863639at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268649" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="61" mass="6483" checksum="29C88F64276175CF" modified="2016-10-05" version="1">MRFSSQFLSISLVLLSTFSLITATPVPCTDRTRDLVLQGILDPSACCSYGVCKGDVNVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVV6</accession>
    <name>A0A194XVV6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_19463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVV6"/>
    <dbReference type="GeneID" id="28815455"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_19463"/>
    <dbReference type="InParanoid" id="A0A194XVV6"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62888" checksum="8E9EBA3FCA0B8383" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWL3</accession>
    <name>A0A194XWL3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078876.1">
        <property type="nucleotide sequence ID" value="XM_018219162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWL3"/>
    <dbReference type="STRING" id="149040.A0A194XWL3"/>
    <dbReference type="GeneID" id="28828888"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727543"/>
    <dbReference type="InParanoid" id="A0A194XWL3"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="36772" checksum="8B8829FE0863FAE9" modified="2016-10-05" version="1">MAEVSYTTYGQPMPDVKGLVIQTPSLPQCGNVNFNFTQTQYSFASGFVGQVRYGSTDEGLMSSVNSTCPQFVMIYGYIDPEISKNITNANISVAWCNPFYQRLDVNVSYLLPNYTIQSAIADENTAVVQALPDIWPITVQSFTDLPTSSNNGAGSDTDPFFQSLLMSDPNPLPLSNISRNDKASDVLSSMESAYQILSAQIANIYLRSVPLSPTPALSGSLTDNSRLRLVQSPIPTRILQGVLAVILFCMIVVFITSWKSDRVLPSSPTSIAAVASLLAGAKLLECFPAGSEWLSNEELRKLEVFGGKEGFSLRWWGEEGNDDGVRFGVDKEGLGNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWQ5</accession>
    <name>A0A194XWQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER lumen protein retention receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_605104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078814.1">
        <property type="nucleotide sequence ID" value="XM_018210380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWQ5"/>
    <dbReference type="STRING" id="149040.A0A194XWQ5"/>
    <dbReference type="GeneID" id="28820106"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_605104"/>
    <dbReference type="InParanoid" id="A0A194XWQ5"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ24459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="370" mass="42114" checksum="51558FD78DAD9E01" modified="2016-10-05" version="1">MYVYLQILGIIENADVDQIFRILGDVSHTLSKCILIFAIHRNHSTEGVSLITQALYCLVFISRYLDLFMFNTLWNTILKIFYILSSLYILFLMLRVYARTRERETAWKLGALCLVGSAIGAPICMMIFRRKAYWGFMELLWTFSIILESTCILPQLLLLRQTTVPTVIDSYYLLTLGSYRAFYILNWIWREFDITDRKPDPVSIIFGVLQTAFYIDFAWVYYSRQRVKLRNGGIVDQDDMRNGWLLRTVFGHKAIVPHAEEDEESAPALGDEEDERPNPIRNGGSKWGARGISVSADDGVLAGERERQNQFPGQESGVVNAEDHLDPDAKMRDPDELAKILDDEDDDDDEGVLPGGEGSAAGSGNVWGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX40</accession>
    <name>A0A194XX40_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078707.1">
        <property type="nucleotide sequence ID" value="XM_018219146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX40"/>
    <dbReference type="GeneID" id="28828872"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727384"/>
    <dbReference type="InParanoid" id="A0A194XX40"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="365" mass="41496" checksum="797676909BE0EB01" modified="2016-10-05" version="1">MEHLQVRFRAAFQVTPEAGYRRLEWKCDCGENLYGDFPAGNENELRAVEQLEKELKLNCKIIWGKRPLSTFERDIIALAGGAPVLQSQHSSGSIKTKGQSTSYPMTNLRNHQAQNIREEARSPIRLRRLAEERGQLGNRSWRYLELCFNSGKHQIQHAELDVTHHTTTDHTFFQKIKTEYFRMSKRRWFFEPKDVRFVEFSVQNMGELAGIINGFDERNPALPPEELVRQGTTWEYKPRPRGPPVPSNIILHELTSKKSKLHTSTTWSRRMPKKLNTSIYAIPDPNEAAFGWGIHIFEGYNVFLITILISVLALLGSAGCILATALWWTLRDDLNGALALGAALAALLAVLLGWAVSFLQGVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2I0</accession>
    <name>A0A132B2I0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_692358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060886.1">
        <property type="nucleotide sequence ID" value="XM_018216524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2I0"/>
    <dbReference type="GeneID" id="28826250"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692358"/>
    <dbReference type="InParanoid" id="A0A132B2I0"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19144">
        <property type="entry name" value="AKR_AKR13A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="342" mass="37835" checksum="CD0DA2D3849FB163" modified="2016-05-11" version="1">MPPQLPTRKLGKNGPLVPAMGFGLMGLSAFYGKPQPDAERFKVLDRAYELGETFWDSADMYQDSEDLIGKWFARTGKRDEIFLATKFANKVVGDGKRVIDSSPEYVRTACEKSLSRLGVSVIDLYYCHRVDGKTPIEKTVEAMVELKKEGKIKYIGLSEVSSATLRRAEKVHHIDAVQIEYSPFAIDIEQPQINLLKTCRELGVAVVAYSPLGRGILTGAYKSPADFEEGDFRKMAPRYSEENFPKNLKLVDGIVSIANKKGCTAGQLTLAWLMAQGEDIIPIPGTKKIKYLEENLGALDVKLSAEEEKEIRDLVEGAEVHGTRYPAAALANLFGDTPELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2J9</accession>
    <name>A0A132B2J9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_602958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060975.1">
        <property type="nucleotide sequence ID" value="XM_018210273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2J9"/>
    <dbReference type="GeneID" id="28819999"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602958"/>
    <dbReference type="InParanoid" id="A0A132B2J9"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="91" mass="10648" checksum="62137DA06D8FD4E5" modified="2016-05-11" version="1">MRKSAHVRFSYGQTDFPIFSSRLYNIQADIKRQLPNQISHLWRDKSDILRWYTFWAVVIVGGLGLFFALVQIVESAIQVEYAVKAYNPVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3M6</accession>
    <name>A0A132B3M6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_790394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060879.1">
        <property type="nucleotide sequence ID" value="XM_018223362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3M6"/>
    <dbReference type="GeneID" id="28833088"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790394"/>
    <dbReference type="InParanoid" id="A0A132B3M6"/>
    <dbReference type="OrthoDB" id="3555571at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="370" mass="41500" checksum="BB26B9E9DD54B6B0" modified="2016-05-11" version="1">MNSDREPMLNASQFAEDLGPQQLRLIQELEKPSPDTIPNGPVVDGIKLGLALNEKRHAANVYEMIYNGRKGGLGPEEERTLASGHEYACLCLQINYFQQAEVVLKEVWVRRQTVLGVANPQTLQSGFQLGQIFFRTERHDAALDMHQAVYRHRRDLFGAHSMETIQSAEIYGQILMCRDSTEVQVQEGWTLLHQTLEVQKDIYGVTTDTVVSALRLAAITAISGRFRQSGELFAWLYEVGVDSVRKPGQFGYSPAKLAVGFAASGMAFLEGNDSKGNRLLERIGEYSADIYGLASAETHLIAYLHAFILFLQRRGRRSKSILRRVFEMRKQHLGRRHPGTKAAAIILAMGILLDSLLSKTKINEELDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Y9</accession>
    <name>A0A132B3Y9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_678093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061480.1">
        <property type="nucleotide sequence ID" value="XM_018213723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Y9"/>
    <dbReference type="GeneID" id="28823449"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678093"/>
    <dbReference type="InParanoid" id="A0A132B3Y9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="188" mass="21460" checksum="571E2DB2BD68A685" modified="2016-05-11" version="1">MSHPEDPTSSPTRRRAVEDYYCDHDANYPCPPPPYAPGAEAVTKTPGVDASHPAKTPPLQIRNIVPDTRSQTQFSLQTDSPPQYQSRPPPPYGIVTNSQRTLVEGMCRNKEVLKLKKQQAKQAREVRMETQAQSAQIEAMRKNRAGTETWKLREAIEWEDEKRRIDAEARRASVEAARQERRRGDRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5A0</accession>
    <name>A0A132B5A0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_399001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061202.1">
        <property type="nucleotide sequence ID" value="XM_018207250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5A0"/>
    <dbReference type="FunCoup" id="A0A132B5A0">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B5A0"/>
    <dbReference type="GeneID" id="28816976"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_399001"/>
    <dbReference type="InParanoid" id="A0A132B5A0"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113606" checksum="4858519802C66958" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5B7</accession>
    <name>A0A132B5B7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_359115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061955.1">
        <property type="nucleotide sequence ID" value="XM_018206984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5B7"/>
    <dbReference type="GeneID" id="28816710"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_359115"/>
    <dbReference type="InParanoid" id="A0A132B5B7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="514" mass="57340" checksum="8C136B23FFB1C5B9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6T8</accession>
    <name>A0A132B6T8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_789357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062481.1">
        <property type="nucleotide sequence ID" value="XM_018223245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6T8"/>
    <dbReference type="GeneID" id="28832971"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789357"/>
    <dbReference type="InParanoid" id="A0A132B6T8"/>
    <dbReference type="OrthoDB" id="4926491at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="37572" checksum="27668CBFD5208397" modified="2016-05-11" version="1">MSSLPTRIRQNIRDHITSPTCPLVLKTTSVTENLGYPIVLDPEWTMLWKSLQEYYPDSTIFVPTVAATILSWCDALTIWLENEENEEHVEQLLDALKARSSLTLVLEISTTSQRPTTAWRANKSVFVIALPKAKPAYLNTILAGFATDLMNLFTASPMISSTNVATKALPVLEDPEDWADLDAELDRNHQTSIHANSAARTQDVDEPMPEVSTLMRPEELTKRPPYLIVVKQEGPMKVVVHGSHTPSLACLEGYLKRWCRGEASRANRPPVVEIKLQESAFGLGLMNDALTLEAIRGREVNAMVILVFVESVLGYAPVNSIGSVGSIWEFRRMRGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6X7</accession>
    <name>A0A132B6X7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_600435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062348.1">
        <property type="nucleotide sequence ID" value="XM_018210158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6X7"/>
    <dbReference type="STRING" id="149040.A0A132B6X7"/>
    <dbReference type="GeneID" id="28819884"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600435"/>
    <dbReference type="InParanoid" id="A0A132B6X7"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17742" checksum="8D46FD65964C4983" modified="2016-05-11" version="1">MASSNEPFYIRYYSGHQGRFGHEFLEFDFRVLGEGKGATARYANNSNYRNDSLIRKEMCVSSLLVDEIKRIIKTSEIMKEDDGKWPKKNKDGRQELEIKIGSEHISFETAKIGSLVDVTESQDPEGLRVFYYLVQDLKALVFSLIALHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8A1</accession>
    <name>A0A132B8A1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_741492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062995.1">
        <property type="nucleotide sequence ID" value="XM_018220713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8A1"/>
    <dbReference type="GeneID" id="28830439"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741492"/>
    <dbReference type="InParanoid" id="A0A132B8A1"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13135" checksum="60E590D7CA4F68C0" modified="2016-05-11" version="1" fragment="single">SLDSGEADFFKLVDEDVAVAEADAKAEANIVYGFDSYRSAVILWLRRTGIEEHTRGLKKDEMHTSFAVPKNAESEPELFLMLELALSRFYTSAAPGQKIRAFDPKKEPNTLKTNFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8F6</accession>
    <name>A0A132B8F6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_724990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062888.1">
        <property type="nucleotide sequence ID" value="XM_018218944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8F6"/>
    <dbReference type="GeneID" id="28828670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724990"/>
    <dbReference type="InParanoid" id="A0A132B8F6"/>
    <dbReference type="OrthoDB" id="3564193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="26912" checksum="F76079847CB22C7B" modified="2016-05-11" version="1">MATVAFTNPPAPGAVGDFTSDPVYEYGTPVFVQWNGNASSLTLWQLQPGAVALFGSPEFLIDVTNTENSSDVTPYTDFNWLVQTSKNLTLSNRFILSLFDVGQATPLCNSHYFEIRPKSGSPVNATSSTVLSSSTQTPVSPSGTVALSLTPAASSSAASTQISNSGLSVGAKIGFGLGVPAAILLGLALGWFLQGLWRRRGEKSPISPVSESQGKVNEIPETVGDEEMPGSFGGKELDGSAGGQELPGSLPPHYELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8T3</accession>
    <name>A0A132B8T3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_326182</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063136.1">
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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    <sequence length="397" mass="45695" checksum="041EF4C8FF4D7D3C" modified="2016-05-11" version="1">MGPMKENPAKRKATEEPSTPSDSKRLKSSTSDSPEPPPQKSHVVQFPEKPAVIEERTGEIEFRVVNNDNKRESLIILTGLKNIFQKQLPKMPKDYIARLVYDRTHLSMAIVKHPLEVVGGITYRPFKGRKFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLERSLWMGYIKDYEGGTIMQCSMLPRVRYLQAGRMLLKQKEAVHAKIRAFSKSHEVHAPPKEWANGVCKIDPMSIPAIKASGWSSDMDELARQPRHGPNYNQLLHLLNDMQNHASAWPFQHPVNREEVADYYEVIKEPMDLSTMEAKLDLDNYQIPEDFVRDAKLIFDNCRKYNNETTPYAKCANKLEKYMWQQIKAIPEWSHLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9W3</accession>
    <name>A0A132B9W3_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid-CoA ligase/ protein binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_629074</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:fatty acid beta-oxidation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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        <property type="entry name" value="ANL_N_sf"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="707" mass="77688" checksum="BC1E10F3F52369A0" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA07</accession>
    <name>A0A132BA07_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_724285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063595.1">
        <property type="nucleotide sequence ID" value="XM_018218883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA07"/>
    <dbReference type="GeneID" id="28828609"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724285"/>
    <dbReference type="InParanoid" id="A0A132BA07"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288060" evidence="10">
        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="65"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ09240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="469" mass="48857" checksum="140B3F905C75D47A" modified="2016-05-11" version="1">MAKMLFSLIEVALLVAPSVAVLHERAYYASQGILEVPITGIPKNVSLSKRQVANPLINMFQGLEYLISFGIGTPPQNITLALDTGSSDTWVNPTCITGQRSDLCAGIAQYVPASSSSSKNLGNSMSLAYGIGRAQGTFYTDDVHLGGADIKAQQFGVASDTQSLDTGLLGIGFGVNFTTAYPNIIDQMAAQNITNSRAFSLNLAGVDSSSGAVVFGGIDTKKFYGKLGKQAIVPYKQSPDGFPRYWITMTSLSVTTPSKTTTTIFSGTAQPVFLDSGGTLSQLPATIVTAIVALFPGAKNVGSGQYTVPCSALQQQGFLDFGFANTTIRVPYHEFVWQADVDLCALGVMANAAGDPTYVLGDSFLRAAYVVYDQDNMNIHLANAASCGSNLVPIGKGLDAVPALTGDCPEPVAAVPKATSATSVSSRKPTSSMMPITTSKPSKTTTTRKGGTTSSKTVTTPAAGVGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAL6</accession>
    <name>A0A132BAL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_288295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063817.1">
        <property type="nucleotide sequence ID" value="XM_018206499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAL6"/>
    <dbReference type="GeneID" id="28816225"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_288295"/>
    <dbReference type="InParanoid" id="A0A132BAL6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="19932" checksum="43B26941ED9FA741" modified="2016-05-11" version="1">MCSCKIWIPRPPKSINKVIRIRPTRTQKLMQSLPANLTMLNITNLNTLRRVSNRQPLSLGSRPNHRHRVTEPVHVFTLGSIRVTQTPLAPGSFNTRTPAHQLADLLLQHRRPSRDPRIFRHPELEPAKFSRVKKGAQSVQDRHPVETNEQTTEEAEGGQVEVDGDPREVRQAGIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBS7</accession>
    <name>A0A132BBS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_597421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064183.1">
        <property type="nucleotide sequence ID" value="XM_018209977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBS7"/>
    <dbReference type="GeneID" id="28819703"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597421"/>
    <dbReference type="InParanoid" id="A0A132BBS7"/>
    <dbReference type="OrthoDB" id="3436860at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="19259" checksum="58910F0C7327EC5A" modified="2016-05-11" version="1">MGFFSNRYMFAVHVLQIILVLLAIGGSVVRLLIVKVPAGAPRSRANTMALGMGAKSLIVILYQVLSEHTAMFRKWASLKANMILNCMEIVFWAAVVFLMIQANLKFCVGTNCILSWVVTGVAGTLSTVAAYTAIVSIMDFRCFKSTGMHRGSEVELKNEQVEDGRSMDEVRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCP9</accession>
    <name>A0A132BCP9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064550.1">
        <property type="nucleotide sequence ID" value="XM_018216012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCP9"/>
    <dbReference type="GeneID" id="28825738"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689999"/>
    <dbReference type="InParanoid" id="A0A132BCP9"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17605" checksum="06743D1B11915EEE" modified="2016-05-11" version="1">MPSARYNTAVKYIEAFNNLDLKSIMSLRAPKCTHQMAPASLGYGDPITNDVYETSISRFGRYISAWPVEIKEVTEDEKNNRVVVWATAQPQWREEAMDGPKEDWEKGGEYMFTMCMDESGEKLVRVVEFLDSKRTEELRALIARASKNLEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDJ3</accession>
    <name>A0A132BDJ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NPP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_596547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064806.1">
        <property type="nucleotide sequence ID" value="XM_018209929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDJ3"/>
    <dbReference type="STRING" id="149040.A0A132BDJ3"/>
    <dbReference type="GeneID" id="28819655"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596547"/>
    <dbReference type="InParanoid" id="A0A132BDJ3"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="24697" checksum="3D26F1EED9910ECE" modified="2016-05-11" version="1">MTLVERNTETRPEIARRSVIDSDAVVGFAETVPDDTLGTAYEAYQPYLYIVNGCVPFPAVNAEGNTSGGLKPTGASDGDCSSSTGQIYSRGEAYGDYFAILYSWYMPKDEPSDGIGHRHDWEGVIVWLTSESSTTADNIVAVCPSAHGGWDCTTDEFSLSGTGPLIKYQSYWPLDHSCGLTTTVGGQQPLIAWESLPTVAQTALADTDFGSAIVPFIDSTFESNLAKCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDR3</accession>
    <name>A0A132BDR3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064915.1">
        <property type="nucleotide sequence ID" value="XM_018220567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDR3"/>
    <dbReference type="GeneID" id="28830293"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740269"/>
    <dbReference type="InParanoid" id="A0A132BDR3"/>
    <dbReference type="OrthoDB" id="5419179at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288151" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="17415" checksum="C5E43B9FECEDBBC4" modified="2016-05-11" version="1">MRFSIPLLTLTTLSTLIFAHNLPFTFQHVFSVQITIAPALPSINVPGGTLVIEPITGGTVNGTINGTILSGFAYPTSLTNTTIDNPSITLYGLTDDNQTFYVSEMGTGSRACQVTRIEMKINGTRYQEFNNGFLVASVVPRNETFVDVEVYLVGNVASDCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRI9</accession>
    <name>A0A194WRI9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_626071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064978.1">
        <property type="nucleotide sequence ID" value="XM_018211093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRI9"/>
    <dbReference type="FunCoup" id="A0A194WRI9">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRI9"/>
    <dbReference type="GeneID" id="28820819"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626071"/>
    <dbReference type="InParanoid" id="A0A194WRI9"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="177"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="323"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="468"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="634"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="825"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="984"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125276" checksum="09F890A5583E79D2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT76</accession>
    <name>A0A194WT76_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_251745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065229.1">
        <property type="nucleotide sequence ID" value="XM_018206205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT76"/>
    <dbReference type="GeneID" id="28815931"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_251745"/>
    <dbReference type="InParanoid" id="A0A194WT76"/>
    <dbReference type="OrthoDB" id="10044505at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="29660" checksum="DD4A8F7721D74BF2" modified="2016-10-05" version="1">MRLVDGMNGGAIGRIHTEPGSSKVLFGPDGTLAYVNHIKSRTVSVISVVEPEVIGTIPSFADAFSDMMISADGLRLWVVHKMVGKTSIIGLLTRTVVGVLDTGAESNHPIFAIVNGSIYSFVTVAATNETKVYSQDCPSTMPLFVTSIKVSGIEPHGIWGSLDETRIYWGNEHSDTMDVADTSSMRLFASVPAGQESQVLVYVAGAVPAASNDTENLGTQGQEKGVENHLINVTNSINSTALITIGGLNGLDIFHMIGRDLEINQRHVATAICTGCGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTJ1</accession>
    <name>A0A194WTJ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_655864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065344.1">
        <property type="nucleotide sequence ID" value="XM_018212360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTJ1"/>
    <dbReference type="STRING" id="149040.A0A194WTJ1"/>
    <dbReference type="GeneID" id="28822086"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655864"/>
    <dbReference type="InParanoid" id="A0A194WTJ1"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267427" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="507"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="713" mass="79515" checksum="2F2E292E6AF88901" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUZ5</accession>
    <name>A0A194WUZ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_722631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065839.1">
        <property type="nucleotide sequence ID" value="XM_018218744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUZ5"/>
    <dbReference type="STRING" id="149040.A0A194WUZ5"/>
    <dbReference type="GeneID" id="28828470"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722631"/>
    <dbReference type="InParanoid" id="A0A194WUZ5"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF141">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267484" description="PEBP-like protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="26566" checksum="D40BC6B943AAD50B" modified="2016-10-05" version="1">MLSSTILAVALAGAAIAFTPSGFQPSSTQNMTVVFGNTLAVNGKEMQKADVAKAPTLGTAQRMFGTYTVMMVDPDIPPATAGGATSELLHWMQAGLVSSNTSTTVAGVTTFELINPMNVTAFATYIQPSPPDKAPNTHRYTQLLLNTTGNTSALTTLARFAMTRTNFSAVNVVNSAGVKIIAGNSFDVSNGTLVQSNITKTTSVAGSGASATGTGTGTRSSATSSSNGTVSSTGTPKSTGGASELTTGGALIAGLGALAAALIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV04</accession>
    <name>A0A194WV04_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_594561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066150.1">
        <property type="nucleotide sequence ID" value="XM_018209812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV04"/>
    <dbReference type="STRING" id="149040.A0A194WV04"/>
    <dbReference type="GeneID" id="28819538"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594561"/>
    <dbReference type="InParanoid" id="A0A194WV04"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase (KR)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="13109" checksum="20B4DE8C3F4098C3" modified="2016-10-05" version="1" fragment="single">FIFLSSLSGIYGSVSQSNYAAGNTFQDAMAQYWIFHGEKTISFNLGWMRTIGIIVENEEYQRVREMGADMNQIEEEELMALLDIYCDPAHPIFPPSRSQLLVGVVTPRDFHFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV97</accession>
    <name>A0A194WV97_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_738532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066248.1">
        <property type="nucleotide sequence ID" value="XM_018220383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV97"/>
    <dbReference type="STRING" id="149040.A0A194WV97"/>
    <dbReference type="GeneID" id="28830109"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738532"/>
    <dbReference type="InParanoid" id="A0A194WV97"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23579" checksum="53AF17CB201DCA3D" modified="2016-10-05" version="1">MAEKPFIVFVLGPPASGKGTLCKRLADAHKQYLYHLSVGDYLRYLINGPLSDQADIIDSVRSGGTRGLVRGDVIVSLLLDKINEEMGKGKSVFLLDGFPRNLEQDEAFKALMNTEFNRGTPDLTISISCPRETARARYLNRKRGDDSEELFDKRYSDYEGRDRKVVELYQKNLVEVRAVEGRSIDQSFQEMTEALYRTPAWKAMMSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVW9</accession>
    <name>A0A194WVW9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_688907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066092.1">
        <property type="nucleotide sequence ID" value="XM_018215803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVW9"/>
    <dbReference type="FunCoup" id="A0A194WVW9">
        <property type="interactions" value="1085"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVW9"/>
    <dbReference type="GeneID" id="28825529"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688907"/>
    <dbReference type="InParanoid" id="A0A194WVW9"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16068" checksum="45FE1C65C57EECE9" modified="2016-10-05" version="1">MPPKKVVRPAQENISLGPQVRDGELVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVATRCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARSGMKIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW24</accession>
    <name>A0A194WW24_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_688625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066518.1">
        <property type="nucleotide sequence ID" value="XM_018215745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW24"/>
    <dbReference type="FunCoup" id="A0A194WW24">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WW24"/>
    <dbReference type="GeneID" id="28825471"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688625"/>
    <dbReference type="InParanoid" id="A0A194WW24"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="326" mass="36218" checksum="C1FE5B04A56B0BD2" modified="2016-10-05" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHSDSQVNRLCISPDKRFLAAAGHHSVKLYDIKSTNPNPLLSFEGHTGNVTGVAFHCEGKWMVTSSEDGTVKIWETRSGSVQRSYSHGTPVNDVVIHPNQGEIISCDRGGSVRIWDLAENNCSHQLIPEEDVPVASVTVASDGSTLCAGTNSGNVYVWHLLQYREKTTLVPITHFTAHKNYITRVLLSPDVKHLATCSADHTAKIWEVKDLETMLPIPGQAPAAQKDPKPFKLESTLTGHQRWVWDCAFSADSAYLVTACSDHYARLWELHSEQIIRQYNGHHRGLVCVALNDYSEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWE8</accession>
    <name>A0A194WWE8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_559163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066658.1">
        <property type="nucleotide sequence ID" value="XM_018208433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWE8"/>
    <dbReference type="FunCoup" id="A0A194WWE8">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="GeneID" id="28818159"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_559163"/>
    <dbReference type="InParanoid" id="A0A194WWE8"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="470" mass="51161" checksum="1ADF199C227BD2B4" modified="2016-10-05" version="1" fragment="single">YSIFNRKERLLLVFLGTFAAFLSPLTANVYYPAIVELSHEFHVSTDLINLTITVYLILQGLAPTFIGSISDVIGRRPAYMICFMVYFAANVGLALQNSFAGLMVLRCIQSAGSSGTLTLANALVADLATSSERGSYMGYATLGAFFGQAVGPLIGGLLNAALGWRSIFWFLVIFSATVFLIFIIVVPETCRAVVGNGSIPPQKWNISVLGYLTGRRFLQPNPSIPVPESPRAPRRPINLLGTVQIMFSKGAGCILLYTGFLFGGFYTQIAMVPVNFTEHFGFNSRQIGLCYLPFGLGCMAAALATGKAMDWNFQRIAKKLNYPIVPGQQNDLSKFPIEMARIQIVIPLAFLGCVTVVMYGWMFHLTKSLAAPLVLLFFLGFSLIGAFTAFSTLLVDFYPDSPGTATAAANLLRCWMGAGAVAFIGPLQAKIGSGFACVAVAICWILSSPLLWIVWKHGPAWREERRIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWH2</accession>
    <name>A0A194WWH2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066683.1">
        <property type="nucleotide sequence ID" value="XM_018220329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWH2"/>
    <dbReference type="STRING" id="149040.A0A194WWH2"/>
    <dbReference type="GeneID" id="28830055"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738116"/>
    <dbReference type="InParanoid" id="A0A194WWH2"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267533" evidence="2">
        <location>
            <begin position="19"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="732" mass="72464" checksum="0332B066613A9AC1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXF2</accession>
    <name>A0A194WXF2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_709746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067016.1">
        <property type="nucleotide sequence ID" value="XM_018217780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXF2"/>
    <dbReference type="STRING" id="149040.A0A194WXF2"/>
    <dbReference type="GeneID" id="28827506"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709746"/>
    <dbReference type="InParanoid" id="A0A194WXF2"/>
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        <property type="project" value="TreeGrafter"/>
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    <sequence length="824" mass="91275" checksum="0F6EDF36943BBA88" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXN9</accession>
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    </gene>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12748.1"/>
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            <begin position="2"/>
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        </location>
    </feature>
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            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="32861" checksum="544CB74ECDBF6D5E" modified="2016-10-05" version="1">MADPLSITASVVGITTAALQSAQFLVKTIDNIKDAPGTIKDLSVDLRVVECVLQELNANVQYASSQIIRSSQIGPAVENCDRACKAFQSQVERWTKHSKEDKIFWISRWKIGLFGPDRIKTFKGQLNDCKSTLNIALTTASLLEIASQKELAKEQKDNILEANEADLEQELIRAGKEMVEIEQSLQQFIVSGGTERDEELEQSKKELLQELERQQAASTLLRNMCEEALSRTVYQRTGQKIKGIKATNDGIALAGFINVPGEELNISQDISDVSANNKGFVIVGVANNVDIKDLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY06</accession>
    <name>A0A194WY06_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_709401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
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        <property type="protein sequence ID" value="KUJ12853.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5296287at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="530" mass="57656" checksum="0BE08E437214B35B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYF7</accession>
    <name>A0A194WYF7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_687881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYF7"/>
    <dbReference type="FunCoup" id="A0A194WYF7">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WYF7"/>
    <dbReference type="GeneID" id="28825323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687881"/>
    <dbReference type="InParanoid" id="A0A194WYF7"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="29401" checksum="EED5FF8E635EB730" modified="2016-10-05" version="1">MPPKNILLLGGHGKVSLLMTPKLLSRSWNVTSVIRNPDQKSEILSAGKNGPGKISVLIESIEDVKSQADAQKILDKVKPDTVIWSAGAGGKGGVERTNAIDRDACIHFIRSAIATQSVVRFMVVSALSIRRNRAPWFDDESYALMTKVNTEVMPGYYKAKLAADDVLAVEGMERNKKDGFGWISLRPGRLTDDAEVGKVSFGKTRARGEVTRADVAEVGVGLLEKDGVSGWYDLLGGDEEVGAAVDRVLNEKVDCMEGEDLKEMRKSAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYN4</accession>
    <name>A0A194WYN4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_651979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067067.1">
        <property type="nucleotide sequence ID" value="XM_018212186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYN4"/>
    <dbReference type="STRING" id="149040.A0A194WYN4"/>
    <dbReference type="GeneID" id="28821912"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651979"/>
    <dbReference type="InParanoid" id="A0A194WYN4"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="363" mass="40194" checksum="1536659695DC914C" modified="2016-10-05" version="1">MAPATRSQASSSPQKPDSYFPHFPPSSRATAPVCSSSRTSPKSEASDATAASASGRGSTLAQPSLSLPDNYQKVYLRQIRQNFVSGQYAPQAQPMSSNNSQMSEQQPAPSTGQPVTPSMAPMKRPTAVELIRLISGPRVDIYIGSDKEHRSIPKDLLCSYSPFFDRCFNGSFREAHEQKLELPEEKIEDFDIFLEFILRGTIAVKPGLRGAEETISQCLDFLKFADKYQLGDVSEAIFKPLFDALWFYTAEIKLPRASRTDNLSAPWQTLGSDPPLVVFKRPNGLERKDIELVFTTCPERSSIRTLVVQALLSVAGGLSGLHKLQEYGDSIEGFAAEVMFVIGNDLRDTYVPAKEWLEGMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ01</accession>
    <name>A0A194WZ01_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_591281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067541.1">
        <property type="nucleotide sequence ID" value="XM_018209645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ01"/>
    <dbReference type="GeneID" id="28819371"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591281"/>
    <dbReference type="InParanoid" id="A0A194WZ01"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="377" mass="43218" checksum="3B919C9BBA4736D9" modified="2016-10-05" version="1" fragment="single">MLFPTLPDILTEADPSLKSAALNGYDAIENAVLAALYFRRMEIREAQVQEANKDTCSWIFEDPEEHQKPWSNFVRWLREETGCYWIEGKAGCGKSTLMKFLRSDARTLNALKEWTGSDELITASYFFWMAGTALQKNQEGLLRSLLHTILTRRRDLIARVFPRQYNAMMTNHGATVHASQHDNDECGLLTVSELKKAFTTLAKQNVKGFKICLFIDGLDEYVGDQFEIVDLFKTITTNSFMIKAVISSRPEPTFVEAFHDSPSLRVEDLTSGDIDHYVQSKLLAHSKMQNHRRQGSELGAKLTHSIASKACGVFLWVFLVVRSLLECLSDGSYPEDLERIIETYPEELHELYQHMFKRMKPSHRDEAFRLFQAIHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ03</accession>
    <name>A0A194WZ03_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_672425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067548.1">
        <property type="nucleotide sequence ID" value="XM_018213286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ03"/>
    <dbReference type="GeneID" id="28823012"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672425"/>
    <dbReference type="InParanoid" id="A0A194WZ03"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="34294" checksum="A46CE2DAC8AD2E30" modified="2016-10-05" version="1">MRFLCFHGYGTSSEIFEQQFASIARALGDHHEYVYLDGEVIVTRTELAGIFHGDTLGYYSGCNSEQIAHVHENVTELLATEEPFDAVLANSQGASLAISYLLHQQIQYPNKALPFRFAVFFTPGVVISPDREYKSKEILSFLDKLNQDDINKILMGILDRNGQTMIEPMKFIGLSNLSAAERELCLNLVQHIDTLLLTRRNFKVAETNAYPDMTAQLDCRDKFPRFFHPVYTDERISIPTVHVIGSGDNQAVKRLAEVAKMLCTKEKVISVVHRGAHEIPNKSEGVEAVVRAIEKADFMGQRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZI0</accession>
    <name>A0A194WZI0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracelular serine carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_756508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067474.1">
        <property type="nucleotide sequence ID" value="XM_018221381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZI0"/>
    <dbReference type="GeneID" id="28831107"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756508"/>
    <dbReference type="InParanoid" id="A0A194WZI0"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267642" evidence="6">
        <location>
            <begin position="17"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="550" mass="61065" checksum="22BEC82E6A09088F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X066</accession>
    <name>A0A194X066_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_737330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067704.1">
        <property type="nucleotide sequence ID" value="XM_018220241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X066"/>
    <dbReference type="STRING" id="149040.A0A194X066"/>
    <dbReference type="GeneID" id="28829967"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737330"/>
    <dbReference type="InParanoid" id="A0A194X066"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF11">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267682" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15317" checksum="0F602FCF7DA44950" modified="2016-10-05" version="1">MGAGYAVIQIILLFLQSTFVIPSVISPSFGCQLEFEFIQQSLPSPVFASSEIDGLNLNITVPSSIPSGAKLPVFVFIRGGGFIIGGNSWPQYNTAKLVEMAVEQNKPIIAININYRVGVFGFLTSEELRNAGYTRNNGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0K8</accession>
    <name>A0A194X0K8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_736734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068088.1">
        <property type="nucleotide sequence ID" value="XM_018220167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0K8"/>
    <dbReference type="GeneID" id="28829893"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736734"/>
    <dbReference type="InParanoid" id="A0A194X0K8"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="19725" checksum="DD987C7FDF385F67" modified="2016-10-05" version="1">MGAPLSHKPRRYWQRTSSVERGRYPGRLVHSGDQKVLSTTRPRYGKVGLDLEVECDTNPTLQCINGPNEEPDILKAVKTMIGNGRGYILSFNTFATFSKEWARPGLIIETAGTASYHGMDLAVNFAAVIGFPGEHHEEKVTLLLRHGNLNVDSDLPNRLRYQWSCEENSNRPTDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0V0</accession>
    <name>A0A194X0V0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_698947</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068181.1">
        <property type="nucleotide sequence ID" value="XM_018217016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0V0"/>
    <dbReference type="GeneID" id="28826742"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698947"/>
    <dbReference type="InParanoid" id="A0A194X0V0"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267691" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="19"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="230"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="663" mass="71729" checksum="9C1004D5520A4B6B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X119</accession>
    <name>A0A194X119_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_708971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13888.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3643at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
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        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="240"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="734"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1305" mass="141272" checksum="783F552FF8B49AF3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1I2</accession>
    <name>A0A194X1I2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_721182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068408.1">
        <property type="nucleotide sequence ID" value="XM_018218620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1I2"/>
    <dbReference type="GeneID" id="28828346"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721182"/>
    <dbReference type="InParanoid" id="A0A194X1I2"/>
    <dbReference type="OrthoDB" id="3524076at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32582" checksum="53F9BF9AD69F2D1B" modified="2016-10-05" version="1">MPYDPDDLYTAEPKLLSLDCFPVFFVQPAAPPDYDLIMAGNTRYHRISEDNRASMESSNPELDAGLLLLDPTRDDDGNPPPKKSYNFSYHPTLLFRFIAICLFIPSFAMLVVTDRPRNLSAIIFICISFVRNILVILHWICSKRLRIRFSIELRNRGPVVGKPKRGCPAWLKHGLLHILIDFILVVVTLITTIIANSGANNWYWRSRHNGLVLPACVLSYIGNAFYLLSFIDLGKPNSITINSGIVFDYGKGNDDDQPSQPPQPQFYRDVEAAGGLGADSRKTGADSPVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1M7</accession>
    <name>A0A194X1M7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_687122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068102.1">
        <property type="nucleotide sequence ID" value="XM_018215431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1M7"/>
    <dbReference type="STRING" id="149040.A0A194X1M7"/>
    <dbReference type="GeneID" id="28825157"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687122"/>
    <dbReference type="InParanoid" id="A0A194X1M7"/>
    <dbReference type="OrthoDB" id="3446116at2759"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
        <property type="term" value="F:S-(hydroxymethyl)glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="20595" checksum="CF96D23227B4A226" modified="2016-10-05" version="1">MTPPLHPLIDNGLKKGRSDFPGGKLHCHCRNDRVEVSLSSNVLHNHVCGCSKCWKPKGALFAIIAVVPVENVKVVANRDKLVVVDKSAVIQRYACKHCGVHLLGRIEQDHAFKGLDFVHVELSDEKGWQEPQFAAFVSSTIEQGFDPKEMDGVRARLRSLGLEPYDALSPALMDALSTFTGKKLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2R6</accession>
    <name>A0A194X2R6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_140531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068831.1">
        <property type="nucleotide sequence ID" value="XM_018205314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2R6"/>
    <dbReference type="GeneID" id="28815040"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_140531"/>
    <dbReference type="InParanoid" id="A0A194X2R6"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="22005" checksum="20F1AE95A20D55A0" modified="2016-10-05" version="1">MSGSVLLLERTSKTSKSHRQSPKTYLTLLQGWPKHKSLCKIYQSSNPPPSNTYCGLCGNTDKLTTTKCCGRTICDDQDNYQMFTYSNASCDRNHSRYTLCSSHHKERHGNGKWQDCEHCRKNFTEDESYVGQGTSSFNFKDDVWENAPSFEPASCKTCNKRIKMGSEAHSYGPNGLTCVSCIGGWDVINKGTRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2U2</accession>
    <name>A0A194X2U2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_686959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068856.1">
        <property type="nucleotide sequence ID" value="XM_018215400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2U2"/>
    <dbReference type="FunCoup" id="A0A194X2U2">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="GeneID" id="28825126"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686959"/>
    <dbReference type="InParanoid" id="A0A194X2U2"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="71802" checksum="DE2321C0D7545412" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4G4</accession>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR45649:SF10">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="56294" checksum="FE01D87D9F2AD0A7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4L5</accession>
    <name>A0A194X4L5_MOLSC</name>
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        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_736162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="48"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4V5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_735336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4V5"/>
    <dbReference type="GeneID" id="28829725"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735336"/>
    <dbReference type="InParanoid" id="A0A194X4V5"/>
    <dbReference type="OrthoDB" id="3556237at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="420" mass="47776" checksum="97EABE77103E92F7" modified="2016-10-05" version="1">MDNNGTVTTTSNKETKLDEESQDIPWSSLQEQYDYDPSPAVLGQRPNKFERLDRRPQEGYHPVSFSEPSELEKHDMTELEPGDIARWVNAPRSITSTALSIKEQQADKRQSGHLERSRTQLSTAVAFPPHESEFIDLLEKHLKAQAKTILCRREKVDSGAVAFLKEFKDDTRQAAVHINGHFRNRTCSLFLMGNVLRNLHPGLPLYLPSLCDPDTAKKEKYPSRQAFDRGDETGKHQRRVYLIRAVRKELIEPVTLLLSYLAPSTSTSTQPLLVRYRYTVFHYVGSDRSAKGGMLLRAVEAAAPEYCRGNRTELHKELSNLNTTFKVYILADWDSIRSELSKESDFDEILIAEAICQTILRTGCLFRQSGNRGEKMTGFFKHLQLEAGDDEPLPNNNGLNVQSALESLRYPDRRNTSFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5D7</accession>
    <name>A0A194X5D7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_111541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069736.1">
        <property type="nucleotide sequence ID" value="XM_018205076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5D7"/>
    <dbReference type="GeneID" id="28814802"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_111541"/>
    <dbReference type="InParanoid" id="A0A194X5D7"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="60921" checksum="525C46AB4F467FDE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5T4</accession>
    <name>A0A194X5T4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_116253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069893.1">
        <property type="nucleotide sequence ID" value="XM_018205110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5T4"/>
    <dbReference type="STRING" id="149040.A0A194X5T4"/>
    <dbReference type="GeneID" id="28814836"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_116253"/>
    <dbReference type="InParanoid" id="A0A194X5T4"/>
    <dbReference type="OrthoDB" id="3701586at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="91" mass="10516" checksum="41233247C354D7B1" modified="2016-10-05" version="1">MSRGSDLSYKHVGVLRTNASDKIVPDTRDYKNQGFSYPVAVQVGNTLVTAYSENKENIWRYLSYHLTIALHSHFNIQAEGIRRLRYVHFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X662</accession>
    <name>A0A194X662_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_686075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069657.1">
        <property type="nucleotide sequence ID" value="XM_018215202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X662"/>
    <dbReference type="FunCoup" id="A0A194X662">
        <property type="interactions" value="1641"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X662"/>
    <dbReference type="GeneID" id="28824928"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686075"/>
    <dbReference type="InParanoid" id="A0A194X662"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="283"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="673" mass="72968" checksum="C79C1090C48D33FB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6B4</accession>
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    </protein>
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        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <begin position="28"/>
            <end position="65"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10175" checksum="D6936D827B394119" modified="2016-10-05" version="1">MGSGLPSIGELQRPERLHDVLAQDKVDDCTPCRVTGAAAFMGLGAYSYYTGHSQLKMQESKILASKSAFGLRARRSGVTGIALTLGLMGLYRLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X799</accession>
    <name>A0A194X799_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_735192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_735192"/>
    <dbReference type="InParanoid" id="A0A194X799"/>
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    </dbReference>
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        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="16685" checksum="E1176239886D5C15" modified="2016-10-05" version="1">MAYTYAEAIQIIIELHFAWDLNSFFGGPREPELYLLMLAFQALAVNVTTFGEAVAQGAAMGDLMWDIGRRQGTVLRRVYEALDNIILSILVPPPGVGLLLSRVEFEVLSRLYDVLEQHDTAGDMDDLVSEEENSEDDADEEDEANEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7A8</accession>
    <name>A0A194X7A8_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">Putative allantoate permease</fullName>
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    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070329.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7A8"/>
    <dbReference type="GeneID" id="28819168"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587687"/>
    <dbReference type="InParanoid" id="A0A194X7A8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="481"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="512" mass="56437" checksum="B67376B26FDD4CA9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X825</accession>
    <name>A0A194X825_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070671.1">
        <property type="nucleotide sequence ID" value="XM_018215061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X825"/>
    <dbReference type="STRING" id="149040.A0A194X825"/>
    <dbReference type="GeneID" id="28824787"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685326"/>
    <dbReference type="InParanoid" id="A0A194X825"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="28727" checksum="35B827779B792E6A" modified="2016-10-05" version="1">MPQLIEKQILDAPIWSILLVNGKEGIFSMGGTSVASDREVERETADDLDRIGGHQSRQEEHGRNEHNSRKSEDDLNEWKWIKVQGAEGWWQVLMRGIWIDGVKILANQPAVLDVNTPFIIAPPLAARTFYSSISGSKQLPPPFDQFTAYPCFNPPRVHFEFASWNFEVLKGKRDQGTFSPGGRFSLGRMTTGSGYCLGIVVESRMGARAAEARESKSGVKVEGGDGLSDVWVIGEPFFRDVQIAFNWRDKLVGMQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8C8</accession>
    <name>A0A194X8C8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_734469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070724.1">
        <property type="nucleotide sequence ID" value="XM_018219910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8C8"/>
    <dbReference type="GeneID" id="28829636"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734469"/>
    <dbReference type="InParanoid" id="A0A194X8C8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="497" mass="56331" checksum="229ECD2F69CC0DA5" modified="2016-10-05" version="1">MTETEPKKNFRSFIWDTDTHLKSKEERKLLRKLDFSILTIGCLGFFLKYLDQGNLANAYVSGMQEDLKMYGNQYTYAGTAYTVAYAVMQVPSTMIIQTIRPSYWLALMEIGWGTFTFAQAGMHNIAQLYAFRFLVGFFESSFFPCLLFILGSWYTKTELAKRVAIFHMTAPLGTAFSGYLQAAVYKSLNGHLGLAGWRWLYICMTVPVGFATFFFLPDTPYTTRAWYLTKEECSLAIDRVQRAGKAPPVKLTLSTFTRIFSRWRWYAFTLGYVLYGTSCQASGYFAIWLKSEHFSVVARNVIPTGTNLISAFCIVLWGFGSDYTGSRIAFILGPLTYGLIPNGILAVWPRSIRLKEFAFLTDGVQLMTAIFYTWANEVCAGDNEERALVISSMNGMQYAVAAWLPIVIFPQTEAPTFRRGFPATFGFVIAALIVIVIIQLLALRERRQKTRDAEVTSGDNVDLEVIEYQSDKKDPHIGAKESEGEEIREEIREKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8L3</accession>
    <name>A0A194X8L3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070865.1">
        <property type="nucleotide sequence ID" value="XM_018215092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8L3"/>
    <dbReference type="STRING" id="149040.A0A194X8L3"/>
    <dbReference type="GeneID" id="28824818"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685461"/>
    <dbReference type="InParanoid" id="A0A194X8L3"/>
    <dbReference type="OrthoDB" id="5415522at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="77" mass="8171" checksum="71E6530D8B26D9A7" modified="2016-10-05" version="1">MPSKDASGSSYTPYTVTSSGTNSQGNNYDTREQPSGPAYHYSNSDGSYYYANGNGSTYHNSGSGSTYTAPDGNVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA41</accession>
    <name>A0A194XA41_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_585023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071359.1">
        <property type="nucleotide sequence ID" value="XM_018209302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA41"/>
    <dbReference type="STRING" id="149040.A0A194XA41"/>
    <dbReference type="GeneID" id="28819028"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585023"/>
    <dbReference type="InParanoid" id="A0A194XA41"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="216"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="913"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="651"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072066.1">
        <property type="nucleotide sequence ID" value="XM_018218408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC27"/>
    <dbReference type="GeneID" id="28828134"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718352"/>
    <dbReference type="InParanoid" id="A0A194XC27"/>
    <dbReference type="OrthoDB" id="3643156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268057" evidence="1">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="349" mass="40007" checksum="40ABDE3B6DA40363" modified="2016-10-05" version="1">MRFWCKVIAFARSCSVTTAWTVDYNQLQPNDNSTAAVRDVDGHVENIINIPGSAEYIALMQELTTHPNRLRPPILNTFSHQFRFLLKIVQRRNNLFLGRPGSTNAATLGSMLRMLRSETESRLSISITTIGLAIPNAAFASHEEVNDALVYAGLKPLPKRAIHDGDFNAVYAAHGYGLCATYADPYKCEKEENAMKDGDELLHLDYTNRTLSANTDWIKMARSKYAATNIVDWELGSDQKGTSGYWENVKERVRRLKGKKEFTQLLLSGERAGDEDFLETVKDALWDAEVEVREQDIDFRFVVARGAAEMQWRRQRGWLDCVQPKYCREKTVWGRLIGRFWRMFELWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC31</accession>
    <name>A0A194XC31_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_556682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072071.1">
        <property type="nucleotide sequence ID" value="XM_018208380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC31"/>
    <dbReference type="STRING" id="149040.A0A194XC31"/>
    <dbReference type="GeneID" id="28818106"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_556682"/>
    <dbReference type="InParanoid" id="A0A194XC31"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13346" checksum="DEA3CF6C253FB867" modified="2016-10-05" version="1" fragment="single">PTRLINIRKFPHVFLEHFPDSSSFSGEYVYLSFNWGKVQPQRTMISTLEDHLEDLGFDQLPQTFKDGIELASFLAISYIWIDALCVIQDSAEDWQREAGRMGNYIRNAACVVSALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCJ4</accession>
    <name>A0A194XCJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_668092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072231.1">
        <property type="nucleotide sequence ID" value="XM_018213017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCJ4"/>
    <dbReference type="GeneID" id="28822743"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668092"/>
    <dbReference type="InParanoid" id="A0A194XCJ4"/>
    <dbReference type="OrthoDB" id="3599804at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="30863" checksum="4A8BCB9DD1ADAF7F" modified="2016-10-05" version="1">MATPAATTAPALPKAHPGERLATFFDNLFKTITAISTLGASLTFSKIVQTPVAPWVDYGISKDTAQTYLGLSWLVFVINLGIVSFATAALSLWRYAAIEWFGTEDSQKRRTVMWYATFVSMVLFALIIVAFIFLGLVIAAYAGPVGWSAIGFTTLAGILGFGVIVWQSPIGSKSIGGPPNEDLFRKDSELYGYSPNRKANAYARKLTGDDTYANVYGDGDGYNEKDAMAVKEQYIDDGFGRRNTLDRSPRFADTPEYTNDLRRMRQIRASDEYRYDGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCL2</accession>
    <name>A0A194XCL2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_54513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071842.1">
        <property type="nucleotide sequence ID" value="XM_018208230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCL2"/>
    <dbReference type="GeneID" id="28817956"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_54513"/>
    <dbReference type="InParanoid" id="A0A194XCL2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17857" checksum="5F9A83046B67A477" modified="2016-10-05" version="1">MASSQHSHRHKPRTHKPPSPILLPISRTNTTTTMPLLLTLTAPSQNDITDKYNSPLSTPSHLIIDLENPDKKFLSRKYGHNPEQLQKELHKMVKDKLAKRVFVAKFPVYQLPMEVVQKRPWIYEYVRDVAQVDAMKEDDEGEREMAGRLRRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCZ7</accession>
    <name>A0A194XCZ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_643872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072381.1">
        <property type="nucleotide sequence ID" value="XM_018211813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCZ7"/>
    <dbReference type="FunCoup" id="A0A194XCZ7">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="28821539"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643872"/>
    <dbReference type="InParanoid" id="A0A194XCZ7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ18026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="61308" checksum="D691A8950F617DFA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD67</accession>
    <name>A0A194XD67_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_583400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ18120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28818937"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583400"/>
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    <dbReference type="OrthoDB" id="272245at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ExoRNase_PH_dom1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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            <begin position="38"/>
            <end position="179"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ18120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="38657" checksum="1776B56462D7E87A" modified="2016-10-05" version="1">MAPSATQQVLLSPAELSYLHTSLSLTPPIRPDGRAPSQFRPLIAETGILPGTNGSARICFADGTEAIVGIKAEMEKSGTGYQQSNNLEEEDARQGSNDWLEVTVEVPGLRDDDSMPIFLAAMLTEALLADGEFTKRLWINRRFHWKLYLDILLLSQALSYPLPLLSLTTHLALLSTRLPKLTSELDEDPLFDDDWEASVYLYPRNSQASHTRPPVTLLVMAVKNNIIFDPSKEELAVAEVVLAVSVGERASGEVDMEVDSKKTRDLRLLAVRTIDPPSRLTPPGIPNALNTATGGTAPTIEQAASQREITQEEGVWQPPRGGAKRKLIAALIQKVLEHGGVAEEVLDGLDGVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDD8</accession>
    <name>A0A194XDD8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_668351</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072524.1">
        <property type="nucleotide sequence ID" value="XM_018213036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDD8"/>
    <dbReference type="FunCoup" id="A0A194XDD8">
        <property type="interactions" value="1149"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDD8"/>
    <dbReference type="GeneID" id="28822762"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668351"/>
    <dbReference type="InParanoid" id="A0A194XDD8"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="215"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="38231" checksum="C89901091D9E1353" modified="2016-10-05" version="1">MADVEAQPTHERKPRKSVAFSEGTTIVDENGSVTMKEDGHDDSKDTAISHSPSTPPLSQALGDFTDPIQGLDDGDKEPTKDDDDDVANMLKGMKKKKTKKPKADEAEAEGGEAAPAEDGGLDLSSMKKKKKSKKPKEGTEDEFAAKLAALDLEGKEGEAEPAEPAEKKLVDAGDMEKGTGIWQHDSEVKIPYDLLLSRFFTLLAQKNPDHASSGSRSYKIPPPQCLREGNKKTIFANIAEICKRMKRTDEHVTSYLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRRYIMEYVTCKTCRSPDTELNKGENRLYFITCNSCGSRRSVTAIKTGFSAQVGKRRRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDM0</accession>
    <name>A0A194XDM0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_614876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072601.1">
        <property type="nucleotide sequence ID" value="XM_018210706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDM0"/>
    <dbReference type="STRING" id="149040.A0A194XDM0"/>
    <dbReference type="GeneID" id="28820432"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_614876"/>
    <dbReference type="InParanoid" id="A0A194XDM0"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="75849" checksum="1F2509FA9853D239" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDR2</accession>
    <name>A0A194XDR2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_644383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072668.1">
        <property type="nucleotide sequence ID" value="XM_018211837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDR2"/>
    <dbReference type="GeneID" id="28821563"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644383"/>
    <dbReference type="InParanoid" id="A0A194XDR2"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="268" mass="29542" checksum="A413E2FFF3053A54" modified="2016-10-05" version="1">MSFPYKNVLVLGATSGIGLALAERMIEHGIHIIAVGRRQENLSSLHQKHGKEKVSTIQFDVTDLAGIPSFVETVTKSHPNLDSIFMNSGIQRKIDFTHPSTIDLDLITTELTTNYTSTIHLIKYFLPHLQSHPSTPTSLIFTTSGLALVPILRCPNYCASKAAMHHLILTLRAQLSYAEASKNVRVIEILPPAVQTELHDQKHQPDIKDGGAFGMPLGAFVDEAWEGLSKGQEDVPVGMVKGSYGAFENERRSMFEGITKRLGGWVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDT4</accession>
    <name>A0A194XDT4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_583585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072700.1">
        <property type="nucleotide sequence ID" value="XM_018209222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDT4"/>
    <dbReference type="STRING" id="149040.A0A194XDT4"/>
    <dbReference type="GeneID" id="28818948"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583585"/>
    <dbReference type="InParanoid" id="A0A194XDT4"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="96"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ18345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="400" mass="42084" checksum="43EB016B4935F558" modified="2016-10-05" version="1">MPPVTSVIPDSIPIPSSVVLEYSLPVTSANAVAIPIPSSIVPEYLPPATSINANIPLPSASASFPPIGVLPPFTLNSLATNSADNPKYRFNAGSSTNIAVYYGQSPATSTTTLTSQCADPNIDIVILAFVISQLDGGKYPSINFGAACGGQTQMMINEAPGLLWCPGLASQIQICQATYGKKVLLSVGGSTSKISFSGPGQAQELGDVLWDVFGPAGNVDPQLRPFGTVEVDGFDIDNEDNMPAHFDALALTLRNHFSHTTAKTYYLSSAPQCPFPDASDPMALLLLCDFVWVQFYNNPSCEIGSAGFSASLKQWSQVLSTSTMATKPKFYLGAPAWSAAGPTAYEGIGGPEGMMGIAEHVEGMKMHNFGGVMFWDGSEGVINVQNGKDIIAWAKEGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEP2</accession>
    <name>A0A194XEP2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_732199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073770.1">
        <property type="nucleotide sequence ID" value="XM_018207892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGT8"/>
    <dbReference type="GeneID" id="28817618"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_490184"/>
    <dbReference type="InParanoid" id="A0A194XGT8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16725" checksum="7C880FBC39E9B556" modified="2016-10-05" version="1">MQCNGHVLYKASMQNRQQKNALILFAQVCNLPAPSTLLAVIIRDFYHFLEMLNGLGIILRRLHSGGVMSLQITSKLLQSFEYEHLEKHQICSQVLTLIYISRVPFIYYKIPLFCVELRHFHNFGVRGFVPSYYDTFHNLNSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH85</accession>
    <name>A0A194XH85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_780489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073925.1">
        <property type="nucleotide sequence ID" value="XM_018222386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH85"/>
    <dbReference type="STRING" id="149040.A0A194XH85"/>
    <dbReference type="GeneID" id="28832112"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780489"/>
    <dbReference type="InParanoid" id="A0A194XH85"/>
    <dbReference type="OrthoDB" id="5396721at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="26966" checksum="8970C02183459BDC" modified="2016-10-05" version="1">MSAEMLRQYVDLILKSPALQHFDTIRIDTKSLAYWPYRYLTDPDAKSMLKLFEDAVSSGKHLAFQAHFSNPRELETPVVQEAIRMISMTSAQIRTQSPLIRMSIERDSGARHYFSVPLLKAYKIFNTAYSKIGGVARTVRGPSMTTLGGKLGIAGTPTINGEPVFALKFFSTQHGLSGCFSQNSTLMRSGSTNWNPKRNSFGKKNVRRLSSSRIQSRQDKCSKGVLSMMIRIETFLNVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHR0</accession>
    <name>A0A194XHR0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_640824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074026.1">
        <property type="nucleotide sequence ID" value="XM_018211681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHR0"/>
    <dbReference type="STRING" id="149040.A0A194XHR0"/>
    <dbReference type="GeneID" id="28821407"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640824"/>
    <dbReference type="InParanoid" id="A0A194XHR0"/>
    <dbReference type="OrthoDB" id="5347061at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="437" mass="50055" checksum="8EECEAF0CC798102" modified="2016-10-05" version="1">MPKHFTTRSDTLQDRLAKIPLKRLPKTFNEAIKITRKLGLRYIWIDSLCIIQDSLDDWRQESALMGKVYSHCFCMLAAVSSSNCHGGLFQTPTLYSVLRERDENDGKIVLLKPTARSWRDSLLESPLSRRGWTLQERELSPRILHFVDGVMHFECRQGFGEGKRSFDGYYSDEARAKTARTIRCMDPILARGGKVQWLESTAAIPEERYNRWLRMVEGYSQRKLSVLSDKFPAVSGLAAEYSYLLKDDYIAGLWRKDLIRGLCWRKGTKTPRSLVIDYGPSWSWAKIVGPVDYGLLQVIDNDGKEVNVAPIDCSSGNQNHQILPFIYDACTEPEGTDPNGTLTFALIRMRVKMIKLVFQQRTTWRVGNEIVEVVWDDKPNEFRSYYLLSLGKVNLGLVVTQTESQKDTYERVGIARITEKDPGTWFSNSVTQDISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJM1</accession>
    <name>A0A194XJM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_682057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074659.1">
        <property type="nucleotide sequence ID" value="XM_018214431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJM1"/>
    <dbReference type="GeneID" id="28824157"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682057"/>
    <dbReference type="InParanoid" id="A0A194XJM1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="72" mass="7905" checksum="7A074FDBB2168A63" modified="2016-10-05" version="1">MAVFSEFFRLHHPVDGRSNRIVPANGVPVDDQLSLAGVMSGCLRHLPTCSRKTSAAPLHSRTVVGLVRYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJX4</accession>
    <name>A0A194XJX4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_580331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074442.1">
        <property type="nucleotide sequence ID" value="XM_018209053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJX4"/>
    <dbReference type="GeneID" id="28818779"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_580331"/>
    <dbReference type="InParanoid" id="A0A194XJX4"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ20087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="479" mass="52795" checksum="53975649B3C54D42" modified="2016-10-05" version="1">MAKTTFLQKIVKNEAMKSDPPEIYDIGSIGGIIVMEAFLKKYNITAATTATLTSNIVSTLQAGCFFGSLIAYYVADRWGRKPSLLIAAGVTILGIIIQSSSDGHISALYVGRLVSGFGVGAASMLTPLYVSENAPRAIRGGLTGLYQLFIAAGTMLSFWINYGTHNNFKPVKTNNATWQVPLALQCLPALCLFLGICCCNESPRWLARQDNWEKATKVLSKVTNLPPDHPYVQMELNEMRDQLENERRLVGGASFMDLQREMWTIKGNRNRALISIGLMVCQQQMTGTNAINYYAPTIFLDLGIPSSNTGLFATGIYGVVKMTTCAAFLLFAADSLGRRRSLLWTSIAQGLAMFVIGFYVRFDPPVKGAAIPPVGYFALTCIFLFAAFFQFGWGPCCWIIVSEIPTARLRAMNVAIAAATQWLFNFVVAQAVPHMLATVGKGGYGTYFIFGSFCFIMFFFVWFFIPETKGMSLERMDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK26</accession>
    <name>A0A194XK26_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_445172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074863.1">
        <property type="nucleotide sequence ID" value="XM_018207577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK26"/>
    <dbReference type="GeneID" id="28817303"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_445172"/>
    <dbReference type="InParanoid" id="A0A194XK26"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8353" checksum="12BC49A11838DEC7" modified="2016-10-05" version="1">MVVFLPPGKCLFMSTPTRCHRCLADKEPNLKTLDPLSNSQPNIQKPGIAKSLWLCRMPSLPCARDLRSSPYPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK69</accession>
    <name>A0A194XK69_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_612348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074542.1">
        <property type="nucleotide sequence ID" value="XM_018210614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK69"/>
    <dbReference type="STRING" id="149040.A0A194XK69"/>
    <dbReference type="GeneID" id="28820340"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612348"/>
    <dbReference type="InParanoid" id="A0A194XK69"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5672" evidence="3">
        <location>
            <begin position="140"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="342" mass="39120" checksum="13E956E3908B6187" modified="2016-10-05" version="1">MSTLHAGSSSPGTGIFVINRARILVVVSLILTWTIASLLPRYKQTVLDLGRERYNDAIEHLPAVKVDWHPKYDPKSQFNASKVALMIEPRPLPHLVPQILHMISVVPPDWRFMFIGSNKSVISVSRSFATQYQEANGKLDLVVLPKPWSIESKEGVYRLLTDLRFYDEFMPEAEWLLKFESDSIMCARSDDSLNDWLHYSWAGAPRSATDRFAGNGGLSLRRISAVRQILNFQARYNDTEPEDEWFGKRLTVLPGAKIANGQQEDHFSVESVWHEKPMGYHVRDGGENLADDVWKDPQRRKENFEYCPELSMIMPMKLERERCEGDNKQGEIVGERKGGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLA7</accession>
    <name>A0A194XLA7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_704866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075229.1">
        <property type="nucleotide sequence ID" value="XM_018217412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLA7"/>
    <dbReference type="FunCoup" id="A0A194XLA7">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLA7"/>
    <dbReference type="GeneID" id="28827138"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704866"/>
    <dbReference type="InParanoid" id="A0A194XLA7"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23069" checksum="AB55BEF806D9D5C6" modified="2016-10-05" version="1">MTILEQQPAYSTTGIKSTAHSPVRYAATEIAPAKSARARGAYLRVSFKNTRETAQAINGWKLQRAIKFLENVQEHKEAVPMRRYAGGTGRAAQGKQFGVSRARWPVKSAEFLLGLLKNAEANADTKGLDTGNLIVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEGEEVVQKSEAVVGRESAHLSSRQRGARQRRAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMG8</accession>
    <name>A0A194XMG8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GA4 desaturase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_770830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075800.1">
        <property type="nucleotide sequence ID" value="XM_018221870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMG8"/>
    <dbReference type="GeneID" id="28831596"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770830"/>
    <dbReference type="InParanoid" id="A0A194XMG8"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36576" checksum="925D014DE40C3A18" modified="2016-10-05" version="1">MPSATMTLPSEPTTMFFYLEVKDGGIIQTYPGTAFEKRRKHVLHDVTINDMRSIREDFNVNNAGFELVEHKTGVKDFGSNEEIEKVYYPECKELIKKVSGASEVHIVSHMCRKSTFAEAQEDAKVKSDTDFVTKNNPARFVHVDQSYRGAEQIMYLNLPEEEVERRLKKRWAIMNVWQPINKPVKKDPLAFCDYRSIDENDFRTVIANLPPPGAGEYGNVSKNLPHKKKVAEYSSNGERSAVYEVTNMAHNPSQKWYYASDMTPEEAWVFKIFDSKKDGRARCAVHSSFPLKGQDDHSDPRTSIELRAFVFWDDEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMJ7</accession>
    <name>A0A194XMJ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_422290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075352.1">
        <property type="nucleotide sequence ID" value="XM_018207418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMJ7"/>
    <dbReference type="GeneID" id="28817144"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_422290"/>
    <dbReference type="InParanoid" id="A0A194XMJ7"/>
    <dbReference type="OrthoDB" id="4159838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="967" mass="106419" checksum="C03C1AA7954B5DE6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNM6</accession>
    <name>A0A194XNM6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_681873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075687.1">
        <property type="nucleotide sequence ID" value="XM_018214389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNM6"/>
    <dbReference type="STRING" id="149040.A0A194XNM6"/>
    <dbReference type="GeneID" id="28824115"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681873"/>
    <dbReference type="InParanoid" id="A0A194XNM6"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="192"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="46008" checksum="BD62038E2971927D" modified="2016-10-05" version="1">MASRIAELAALISSNTQKIDEYLASNSLPRPSFEEDGPVKLGLPAELEAARSATLNATAELEALLKTPDDLLRPILNGTSLEAISRYDMARKVPVGGTITFEELAEQCGLYEPDVRRIIRFAIVHHFIFREPSKGVVAHSAASRRLVDDQGARDGLGVMFDDCYQSFGRTVEAMEKYKGQEMAQTGWALSHNGMSLFETFGKVPAKAKRFAGSMAAFNASPMMSHKHIATNFPWETLGEATAVDLGGSHGELCAALAPTAPKMKFIVQELPRTVQSVNRDALPSAVAPQIEFMEHDFFTPQTVTAAVYIFRQIFHNWADSNVIKILRQLIPALQPGARILVHDLLLPEPGKLPLMMERQIRAMDMLMLSICNARERDEADWRQVFTEADPRFKVLRVFTPKGSALGLVDAVWERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNX0</accession>
    <name>A0A194XNX0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_778229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076216.1">
        <property type="nucleotide sequence ID" value="XM_018222195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNX0"/>
    <dbReference type="GeneID" id="28831921"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778229"/>
    <dbReference type="InParanoid" id="A0A194XNX0"/>
    <dbReference type="OrthoDB" id="5406607at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="432" mass="47403" checksum="CA67272DDF4C2729" modified="2016-10-05" version="1">MNFTLVVPNGTTNHGNPHLLCTPPKWYDVALFYFANYFAHAATVVSYPGQGTLETALAVVKALLLPGTGVFPAAETTLRHPALIRGDALAQANRARALCMVVKSRPRRLCFVNNPRRGIAALRPNNFQLERLDAKHRWWECKSAEGRVSMGSTIHGEFKLPRGYDLNYVPLTASLEFAKPGEVLVDPGTTTESMTGPMFLDYSPRLESTYNFPKLFVSLAQATWACVTLYRARGDQIERYGYAAFGLTVAPYACMSIINIVANLLAPDYPSIFLVRTPSMDEAEAKGGYCSGELHVKINPESAVMHDEYTYSAAESGILGVLLSLTPLAIIGGLSHFRNQKSTSIQRGFTMSWVVFGIFTAVNSASVYSSVDYDWSGQRLLGNGRFSSLGYAYKSSLVLRNIYFMAVWGVASIGGMVVVGKMIAEYGICTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP57</accession>
    <name>A0A194XP57_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_608715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076385.1">
        <property type="nucleotide sequence ID" value="XM_018210506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP57"/>
    <dbReference type="GeneID" id="28820232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_608715"/>
    <dbReference type="InParanoid" id="A0A194XP57"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43640" checksum="A788954C353F2D73" modified="2016-10-05" version="1">MKKTLLLCFIHGFKGGDDTFGGFPEHLRALVSHALPKVDVQAIVYPKFETRGDLAECVSRFRDWLLEKVIDIEVSRHTPSPTIDPSVHTILIGHSMGGIVAADTILALTSDRAVTSSRPTSSHSTTQPEGQAPAPPPKPELNTLMFPYIRGVLAFDTPYLGISPGVVAHGAEGHYNAASSLFTEFSGLSSAIWGSKATTSSEAKEEKKPIAALPAPPSVEATSSSWGKWGRIAAIAGTGIAVAAGGTAAYLNREQISQGWSWASSHLEFIGCLARPEELKKRVAGIVTLNRELGTGWGNLYTRLGQKAVSKSDGTTLVGSVIGNTRTFCNLPVGKSEARPFWQEAINDAARDEAGAHMTMFYPKDNPGYYAMSEQAKTLIVQWTMDEWYESSTGETVQFAIENEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPK7</accession>
    <name>A0A194XPK7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_577048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076540.1">
        <property type="nucleotide sequence ID" value="XM_018208868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPK7"/>
    <dbReference type="GeneID" id="28818594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577048"/>
    <dbReference type="InParanoid" id="A0A194XPK7"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="63924" checksum="C5D0AE4CF65E6859" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPR8</accession>
    <name>A0A194XPR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_704835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076543.1">
        <property type="nucleotide sequence ID" value="XM_018217410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPR8"/>
    <dbReference type="GeneID" id="28827136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704835"/>
    <dbReference type="InParanoid" id="A0A194XPR8"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="2">
        <location>
            <begin position="461"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="580" mass="64228" checksum="79E35ABF475454CB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRD5</accession>
    <name>A0A194XRD5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_680424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076642.1">
        <property type="nucleotide sequence ID" value="XM_018214079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRD5"/>
    <dbReference type="FunCoup" id="A0A194XRD5">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRD5"/>
    <dbReference type="GeneID" id="28823805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680424"/>
    <dbReference type="InParanoid" id="A0A194XRD5"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
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    </dbReference>
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            <begin position="429"/>
            <end position="881"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <sequence length="911" mass="102877" checksum="80A7547D6905BDCA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRX1</accession>
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        </lineage>
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </location>
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            <begin position="199"/>
            <end position="214"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="23329" checksum="D3968D6E2E4E7E10" modified="2016-10-05" version="1">MSTNGNTTPPNDSATRNRRGSFTSQTFNNIFGRSNSTSGGPTAPFPGPITTAAAQDQRRRMSISTLGLSGTSPTQNTAFPFGARRGSVSTAGSDSIDENAIDDEEGPGRSQPTTPFTRRVSFGAQALRSVRGSGSPGTSGEGGFNWSEQLRSRAESSVSQSQRPSFSTSPTAKPMHERAKSITEMPAPPTAVPAPAPARPERKKPDAFQERILKGDFYMD</sequence>
</entry>
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        </submittedName>
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        </lineage>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSQ4"/>
    <dbReference type="GeneID" id="28815304"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_175368"/>
    <dbReference type="InParanoid" id="A0A194XSQ4"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ23228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="102" mass="12083" checksum="52E25839C4074C4C" modified="2016-10-05" version="1">MLLISEMGLLWSSVYFFQACVLAPFLCLRTLKSQLLQILYNRFLPHTKKTCSLAFTKKMYHRRNLTYKFCPSEWRPDLAVSLCTDNERWKILNALESFTSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSQ5</accession>
    <name>A0A194XSQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_179638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205600.1"/>
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    <dbReference type="GeneID" id="28815326"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_179638"/>
    <dbReference type="InParanoid" id="A0A194XSQ5"/>
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    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="21499" checksum="CD0BA81AA45D34DE" modified="2016-10-05" version="1">MTVTRNDNWSRSETSMLNRLLSTSRANIPSKAISLQGKTLRDTDIPPNEQARSSQHKPKIHSTAIPKPGYPASNQGSSTLGGTPRNQDIHPSSSSKISRHTLSQHHHPQTQLPNPPHSTPTKIPNLHQLPPGTHTHIPTAAACTYTLTSVDLQGPEHRCGSFRNRNTVGIAPNTTGHDELAACFPMERFLPLCLPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTB4</accession>
    <name>A0A194XTB4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_180647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077741.1">
        <property type="nucleotide sequence ID" value="XM_018205608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTB4"/>
    <dbReference type="GeneID" id="28815334"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_180647"/>
    <dbReference type="InParanoid" id="A0A194XTB4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="27729" checksum="0D077CC94657CF71" modified="2016-10-05" version="1">MENSHTDFLWWESAVPGSQIIQIQVCVQNTSKSDLEPKDSNPDPWTFRINTRPCGLLRACHTSRKVWMRTHHSSIPLQNDQKLFFDAECDIIYLINLTDIPFGKIDRFRICPLFSPPIVAPRSRERFSAVKKLAIPLLQYLDLFSNCDMFEFLHNFKSLDTLHFILPSQGQSQDSLFNNEGLRFESRAGAEAVLGTKIKEKAYQKWSDAHLAYLADYKKRFQVDWNLPKIEPMYGVART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUG9</accession>
    <name>A0A194XUG9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP7</name>
        <name evidence="8" type="ORF">LY89DRAFT_679148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078213.1">
        <property type="nucleotide sequence ID" value="XM_018213812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUG9"/>
    <dbReference type="FunCoup" id="A0A194XUG9">
        <property type="interactions" value="1303"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUG9"/>
    <dbReference type="GeneID" id="28823538"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679148"/>
    <dbReference type="InParanoid" id="A0A194XUG9"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000056">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="363"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="681" mass="77287" checksum="23D39BDED212140D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUQ5</accession>
    <name>A0A194XUQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative thiosulfate sulfurtransferase TUM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_662571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078124.1">
        <property type="nucleotide sequence ID" value="XM_018212653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUQ5"/>
    <dbReference type="FunCoup" id="A0A194XUQ5">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUQ5"/>
    <dbReference type="GeneID" id="28822379"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662571"/>
    <dbReference type="InParanoid" id="A0A194XUQ5"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="187"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="34389" checksum="645DD0BDF4D0BED9" modified="2016-10-05" version="1">MASSRSLSSYLVTPTELQAALKKNSPSKISTAPRTVPVCASWFLPNDGRNGLQTFREKRIPTARFFDLDKVIDKHSPYPHMLPTASDFAKAMSGLGIKRDDTVVVYDSQELGIFSAPRVGWTLKAFGHDSVHVLNNFKLWVEEGYPTESGEFWDVDTCVYPIPEFQASKVIDFEEVREIAKDVNKEGSEGVQILDARSHGRWLGKDPEPRPGLSSGHMPGSISVPVSDLLDPFKKTILPGDQLRKIFESKGVDPNRPIINSCGTGVTAAVIDAALSEAGYGHESRRRLYDGSWTEWAQRVKASDNLIVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVN3</accession>
    <name>A0A194XVN3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cellular morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_727108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078419.1">
        <property type="nucleotide sequence ID" value="XM_018219120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVN3"/>
    <dbReference type="FunCoup" id="A0A194XVN3">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XVN3"/>
    <dbReference type="GeneID" id="28828846"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727108"/>
    <dbReference type="InParanoid" id="A0A194XVN3"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="230"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
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            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="902"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ24064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="126046" checksum="B039FBA79CD8D255" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVT7</accession>
    <name>A0A194XVT7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_692995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XVT7"/>
    <dbReference type="GeneID" id="28826334"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692995"/>
    <dbReference type="InParanoid" id="A0A194XVT7"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268712" evidence="1">
        <location>
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            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
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            <begin position="35"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="26845" checksum="9B29A4F02F9F1551" modified="2016-10-05" version="1">MILNTPFTRLFAAFSLIAAARESVANGAALRILPLGDSITYGFLEPEGNSYRRDLQCLLSEGGSPVQYIGQLSNGNWPNNATDGFIGQTIDQISASGDPEITGSPKANVVLLHAGTNDMIGDDTVDEAPARLGNLIDKILSNSPATFVLVAQILNDANSTVNDRIQVFNSQLPAIIEARSNAGKPVRLVSMSSVPTTDMIDGTHPNEVGYMKMANIWYPALVQAGEDGLIVAAEGVVTDGGPGSLPAGGGACSTLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWA6</accession>
    <name>A0A194XWA6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_634522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078776.1">
        <property type="nucleotide sequence ID" value="XM_018211392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWA6"/>
    <dbReference type="STRING" id="149040.A0A194XWA6"/>
    <dbReference type="GeneID" id="28821118"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634522"/>
    <dbReference type="InParanoid" id="A0A194XWA6"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="49"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="52974" checksum="B40B6D372129FC21" modified="2016-10-05" version="1">MTNYNGLFGLQEQDYEDGNHTYLTQAFLTPSQSIPGVPARYAEEQSQGRALYVGGAPKGWQNEIVRSIFGLWGRVEKLPVLISLSAEETFRWIVMANEGEAATAMEQLHGRKHANGYLSVSMSLPPGRTLTLVKKELLAELPDFNEYGDPEKTPVPQLHHGHPPVRDTSDEKTPTNNHPTFEFTVEDEDSGEFYDDDIRSPEIPPPSECSPLSTPAKDEPKDGFVTQASSWANIAGTDPNITFIDLKPTRRREGPRLKSVGRIPQVVRTVNQNVARLVFLFNLPSTITATDITNAIKEGPLVKMQFGFDADTKARYCGVIFQNPRDAADFEAVLDKEKKDSKPDRFRFIVEHARAEQYGLEDTLRAMGPPMWATRRLTIVKGGFFFMFGERQMRDICEKLVGEDCVQLIWLYNGGNATVVFTDVSAAIKVKKEFDRRAARAHSGEEGTSAVWEGVQTTFSKDPCVAPLELKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX81</accession>
    <name>A0A194XX81_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_22031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078757.1">
        <property type="nucleotide sequence ID" value="XM_018205936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX81"/>
    <dbReference type="GeneID" id="28815662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_22031"/>
    <dbReference type="InParanoid" id="A0A194XX81"/>
    <dbReference type="OrthoDB" id="10632330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="363" mass="39783" checksum="F81799729A5B0ECA" modified="2016-10-05" version="1">MPEPVSTSRKKTTTMSFKSALLNPKSRRQKKRVHWDASAKDNEYKMQPRTPALAPNKKTATAEKVMAAQRAKLQNGGKSLTSQGSSYRSPSPHPFSKTSWSALDSQSQSVNRLADRNPPPPPKAAGSSGHAHSNHGQSNPITTRTSTHHQGKVYAPTTSQSSKIQSQQTHAPKKAGESSTHSQRHPTSANTATKMATHRPQPSVPSQGKAAQSTRHQSQSSVTTDQSHKAVHHREKPAVATAPANTGARRDPKHSGQESSKKRSMAFARVPPAVPDPPERRWVQPPPTPRPARLPTPDLQEIGGRYFCHCDVGHRNQDCMSHRPDATRNANLDMNQMDINLQAAMAQIQADRLAYLEMHGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1F2</accession>
    <name>A0A132B1F2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_744045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947451">
        <property type="protein sequence ID" value="KUJ06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060563.1">
        <property type="nucleotide sequence ID" value="XM_018221013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1F2"/>
    <dbReference type="GeneID" id="28830739"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744045"/>
    <dbReference type="InParanoid" id="A0A132B1F2"/>
    <dbReference type="OrthoDB" id="3543696at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="20017" checksum="9CCFFF6F2BDD3BAC" modified="2016-05-11" version="1">MASDWPPSTAPSITPLMPSFSNTLPKEQFQASQMNAKPAPSQLYDMAGASRLSAPDPYPTIASNPSLAPLPIDGNLSLAEDLFQPLDPSLNPTFVPAFDPAFDPAFFDKLHEGRYWCEVLGCLSSFTRKADRDRHVRSWHNCATLHFCPVPGCKKSLGKPYSRKDKLQEHMQKKHPAPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3A5</accession>
    <name>A0A132B3A5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_743512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061231.1">
        <property type="nucleotide sequence ID" value="XM_018220958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3A5"/>
    <dbReference type="GeneID" id="28830684"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743512"/>
    <dbReference type="InParanoid" id="A0A132B3A5"/>
    <dbReference type="OrthoDB" id="3552531at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287805" evidence="2">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19941" checksum="82FC01FBFC6C93FF" modified="2016-05-11" version="1">MGDLSHFLPPLILLALFRPAFCMPLTASLTRRYVPPETYVAAAKLSAKAIILIVIFVLVSVILSTCTCYICIKRRRSRARARRLAREREQSKQLKPRINKRNARFFAPGLVMDKIERDRLRDMRETEKAWAGKEDQYEMWKMNSGVHVEELKRPETAKGGWREVLRGVVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5M5</accession>
    <name>A0A132B5M5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_711904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062070.1">
        <property type="nucleotide sequence ID" value="XM_018217936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5M5"/>
    <dbReference type="FunCoup" id="A0A132B5M5">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B5M5"/>
    <dbReference type="GeneID" id="28827662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711904"/>
    <dbReference type="InParanoid" id="A0A132B5M5"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007229975" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="22526" checksum="FFDA8BEC65B34391" modified="2016-05-11" version="1">MKTWDISVLLVITFTFVFLSQSVQATKGPKITHKVYFDVNHGDESLGRIVIGLYGKTVPKTAENFRALATGEKGFGYEGSTFHRVIKNFMIQGGDFTKGDGTGGKSIYGAKFADENFKLKHSKKGLMSMANAGQDTNGSQFFITTSTPSHLNGKHVVFGEVMEGYEIVEKIENVSKDGRDRPTVEVKIVKSGELEVPEEGIHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B634</accession>
    <name>A0A132B634_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_789522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062217.1">
        <property type="nucleotide sequence ID" value="XM_018223264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B634"/>
    <dbReference type="GeneID" id="28832990"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789522"/>
    <dbReference type="InParanoid" id="A0A132B634"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123906" checksum="B0F6C690D4A740AC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6B2</accession>
    <name>A0A132B6B2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde reductase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_356874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061894.1">
        <property type="nucleotide sequence ID" value="XM_018206967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6B2"/>
    <dbReference type="GeneID" id="28816693"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_356874"/>
    <dbReference type="InParanoid" id="A0A132B6B2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="35837" checksum="1543983DB32C532B" modified="2016-05-11" version="1">MAAPAVTGPILTLNNGVKMPALGFGTFANEGSKGETHKAVVHALDAGYRHLDCAWFYQNEDEVGSGIREFLSQNPSVKREDIFITTKVWNHLHEPEDVEWSLKNSLEKLQTPYVDAFLIHWPIASEKNADRTVKIGADGKYVINQSLTNDPSPTWSAMEKLYAAGLTKSIGLSNFTSAGIAQILKFAKVKPAINQIEIHPFLPQQPLIDYCFSQSIIPVAYSPLGSQDQVPGTGEKVSTNKELNKVAEKNGWSLAQVLIAWGLKRGYAVLPKSSNEGRIKGNAKLVELNEEDFEAVDKVASGRWSRFVNMKDTFGYDVWPEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6D2</accession>
    <name>A0A132B6D2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_789228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062323.1">
        <property type="nucleotide sequence ID" value="XM_018223232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6D2"/>
    <dbReference type="STRING" id="149040.A0A132B6D2"/>
    <dbReference type="GeneID" id="28832958"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789228"/>
    <dbReference type="InParanoid" id="A0A132B6D2"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="40799" checksum="FD0DB58BB371D441" modified="2016-05-11" version="1">MADAISKDIPLNSVQIEALVVMKIVKACSATFPTTATGALVGMDVNGTLQVTNSFPFPTADVAASDSHPNDHMAASNIAAAAPRSKANGTYQTEMIKYLREVNVDANGVGWYTSANMGNFINLGLIENQFHYQKENNEKTIALVHDVSRSSQGALSLRAFRLSPTFMAAFKENKFTTEIMQKSKLTYKDILVELPIIVHNSHLLTSFLHQLPAELPKKDLEYPSSLSELTANPPPVPLYPNLDALDLSIDPFLERTCDQLLDSIETHYTELNNFQYFQRQLAREQTKVTAWKTKRAAENATRATQKLAPLPEDEWERLFKLPTEPSRLEGMLNAKQVEQYSRQVDGFTASISGKMFAVKSNLLPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B776</accession>
    <name>A0A132B776_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_600285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062615.1">
        <property type="nucleotide sequence ID" value="XM_018210151.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B776"/>
    <dbReference type="GeneID" id="28819877"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600285"/>
    <dbReference type="InParanoid" id="A0A132B776"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="1127"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08260.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2039" mass="225490" checksum="074BA89D91C84C0B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B784</accession>
    <name>A0A132B784_MOLSC</name>
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        </submittedName>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="454" mass="51627" checksum="52CD8AA127433C91" modified="2016-05-11" version="1">MLIGHYVCVFDPAEAGLSKEKEKANPIDEEVLKILRRWVRCPENTKLWGEAFQKLVLSMSDQQIITGIALMVSAITRLRCGISAYHWQITIYLVWFSSFTHLATLTFLRGYLHENSPMRVWRFCFMNILILLLLAALVPTGNRNWLPDEGPDLTGSPAWCLFKYHSRGVNVTSFTTMLFSVLVLCISYATRAIKLFQWSSKYSRLILRTKPGNVLKSHIQKLYRGRENAKTKRWIFSIPYNILSAVLLVVRSWMDVLESMLWEITWLLIALIWGTLRLFATRNSTIDENYNILEENSWGFGQCLPTAMLLLLLFSGIETYIETKRAPAEASSVSASPRVSSLSIDTGGNKTPVISASAESSPFHSTSPHDEDITDQEAAETRLDQQLGGVVRSATTLSLEERSLGSLSFCQIMSRQMDSNINIGLNQLSRVDRAGSLRSRLRLRYFRYNIGLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7B6</accession>
    <name>A0A132B7B6_MOLSC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KUJ08302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28314" checksum="5D76B7F8F0FD6253" modified="2016-05-11" version="1">MGYFVVDFGLVLHQQSVSLKPLVDQARNQNSNGTKTQHALDFNLQNLQHRYWALNNWQLEAAWRGDLIDMPTVSSQKLAKLDRGDKIAKVFALIQILYLLVQIIGRKVASLPSTQLEIATLAFAVSSSITYVLHWKRPQGVDSVYILKAKKVPTLELVTEIASCGATYVWAKNRTPKNIGTGFELDLAPFPNDGGNYTALEGDFSRKVWDRPGGNYEILSQGLGAMVGGILFGGCHCIAWNFQHRSNNLGGRSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7W2</accession>
    <name>A0A132B7W2_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="7 8">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7W2"/>
    <dbReference type="GeneID" id="28831371"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764658"/>
    <dbReference type="InParanoid" id="A0A132B7W2"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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            <end position="64"/>
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        <location>
            <begin position="70"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="500"/>
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            <begin position="38"/>
            <end position="577"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="577" mass="62895" checksum="EAE70D4DA753914E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9H1</accession>
    <name>A0A132B9H1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_690591</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063403.1">
        <property type="nucleotide sequence ID" value="XM_018216126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9H1"/>
    <dbReference type="FunCoup" id="A0A132B9H1">
        <property type="interactions" value="1469"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9H1"/>
    <dbReference type="GeneID" id="28825852"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690591"/>
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    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000812">
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    <dbReference type="GO" id="GO:0043138">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="P:box C/D snoRNP assembly"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="470" mass="51470" checksum="84254AF2F5950857" modified="2016-05-11" version="1">MAAAIQTVSESKELRGLNLIAAHSHIRGLGVDPITLEPRPSSQGLVGQEKARKAAAVILQMVKEGKIAGRAVLIAGPPSTGKTAIAMGMSQALGVDVPFTMLASSEIFSLEMSKTEALEQAFRKSIGVRIKEESEMIEGEVVEIQTDRSVTGGTKQGKLTIKTTDMESVYDMGTKMIDAMTKERVMAGDIISIDKSSGKITKLGRSFAKSRDYDAMGVDTKFLQCPDGDLQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSYINRALEDELAPIVIMASNRGNSRIRGTNYRSPHGLPLDFLDRVVIVSTHAYQKEEIQQILSIRAAEEEVDVTPDALALLTKIGQETGLRYASNLITTSQLIAAKRKAKQVSIEDVQRSFQLFYDSGRSVKFVSDFEKRLIGESGEVNFSVTNGHGDAMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9J1</accession>
    <name>A0A132B9J1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_658090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063386.1">
        <property type="nucleotide sequence ID" value="XM_018212459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9J1"/>
    <dbReference type="STRING" id="149040.A0A132B9J1"/>
    <dbReference type="GeneID" id="28822185"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658090"/>
    <dbReference type="InParanoid" id="A0A132B9J1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF24">
        <property type="entry name" value="RNASE H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="78"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="26081" checksum="97B22F5D4329A57A" modified="2016-05-11" version="1">MKDEFDSRDIGQALRKVCIRGRAPGTRKVRPRRGLQTSRIAKRQPVTIPKTTRTFNIEQHGAKAYNDPTSNLRRLESDPASLVVAVHGCCSANALSSARASYGVFVSEYALNLNRNGTVPDPFMQTSQSAELYATMKALDVVHDLIIAGEDLSHVVIKTISSYLEKGLSSFIWKWASNGFKNTEGRPVVNGRAFRFLHERVVLLEKEYGTRVSFCLVRKDQNVQAGELAREALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9P4</accession>
    <name>A0A132B9P4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_676341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063318.1">
        <property type="nucleotide sequence ID" value="XM_018213575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9P4"/>
    <dbReference type="FunCoup" id="A0A132B9P4">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9P4"/>
    <dbReference type="GeneID" id="28823301"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676341"/>
    <dbReference type="InParanoid" id="A0A132B9P4"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="595" mass="65923" checksum="FE85081D2F7B00A2" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA05</accession>
    <name>A0A132BA05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_690298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063590.1">
        <property type="nucleotide sequence ID" value="XM_018216069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA05"/>
    <dbReference type="FunCoup" id="A0A132BA05">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BA05"/>
    <dbReference type="GeneID" id="28825795"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690298"/>
    <dbReference type="InParanoid" id="A0A132BA05"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000008">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288038" evidence="1">
        <location>
            <begin position="19"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="364"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="604" mass="68359" checksum="9E10753AE62DCD71" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA36</accession>
    <name>A0A132BA36_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_741693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063214.1">
        <property type="nucleotide sequence ID" value="XM_018220742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA36"/>
    <dbReference type="STRING" id="149040.A0A132BA36"/>
    <dbReference type="GeneID" id="28830468"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741693"/>
    <dbReference type="InParanoid" id="A0A132BA36"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="476" mass="54470" checksum="AC85B6B90D144027" modified="2016-05-11" version="1">MLSEFLEGTYKKYKNDTSTFLKWLYETGTKCGYVPDAPTTAKKQVEITPQKSARLKGKARKEAKAAKLVATSMPDTSAGVLSHEVPRRDLMPLAQAVLYSQDSSIKVPVKILQVGLRAVSTRKKLTESFSKNTEASDVETLESNYSHSYFNDLMERVILTLQPRFATMAGTNIKEKDPTQNNETIADLSAEPDYKFYEAEEDAREAKAFAFHCLFTDLNKLRSYVERVWRDYREDKLDLITASVVTNTAVQLAIRTQDEFVASFPGTGSYKDTWVTLYTEMGVKLFKEGHTFGMFNVSEDVEDWAFRRAYSILSEFTKVLNPKSIPMVKRGFYGVYHPQADRTRMSRIEKQQEDVQVLLEILPEFCFLAKFDIAMLGQDEVTRGLRQFALTKAIPIWLVFAVEIFLNIHHILRETVDSGFQVLTLTATRFTQTLNRYFELSDGFTKPKSWPVQNEQLFHILKDLMGIQIFNDAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAI9</accession>
    <name>A0A132BAI9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_676215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063777.1">
        <property type="nucleotide sequence ID" value="XM_018213567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAI9"/>
    <dbReference type="GeneID" id="28823293"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676215"/>
    <dbReference type="InParanoid" id="A0A132BAI9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28590" checksum="63AFA433175FDCE6" modified="2016-05-11" version="1">MPDFGIFCADKISACPINTFRLNDVNRADTLSACSARMRKIYFIVRRRIVFDEAGELLKIIGFGFHFPTDRLRFYREFRQHQAEKIAFAKAESLAHPRNTTQLVFGPQLYEAPLLCEYPSNPGLIIPQAYCVNLGCDHSITDHQAVIVDDIRPFIWQSVQTQYLEKVYSVKHVDDCLLRAIRSDPKVVLVTCDFYDDNVFENLGSSSEYSRTLPDSAIIVEEIENEDEDTPFCMNFIKSNSLTARLPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAY4</accession>
    <name>A0A132BAY4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_598857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063514.1">
        <property type="nucleotide sequence ID" value="XM_018210061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAY4"/>
    <dbReference type="FunCoup" id="A0A132BAY4">
        <property type="interactions" value="1401"/>
    </dbReference>
    <dbReference type="GeneID" id="28819787"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598857"/>
    <dbReference type="InParanoid" id="A0A132BAY4"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="823"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="859" mass="96087" checksum="90BB6207B34F1688" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCB9</accession>
    <name>A0A132BCB9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription factor TDA9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_596986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064268.1">
        <property type="nucleotide sequence ID" value="XM_018209957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCB9"/>
    <dbReference type="STRING" id="149040.A0A132BCB9"/>
    <dbReference type="GeneID" id="28819683"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596986"/>
    <dbReference type="InParanoid" id="A0A132BCB9"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="263"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ09913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="749" mass="83583" checksum="E2E2BEE9F4D8EADB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCK0</accession>
    <name>A0A132BCK0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_689965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="3"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064500.1">
        <property type="nucleotide sequence ID" value="XM_018216003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCK0"/>
    <dbReference type="STRING" id="149040.A0A132BCK0"/>
    <dbReference type="GeneID" id="28825729"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689965"/>
    <dbReference type="InParanoid" id="A0A132BCK0"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase (NOS)" evidence="11">
        <location>
            <begin position="165"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ10145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="390" mass="43667" checksum="A3C949ACF78B3FDE" modified="2016-05-11" version="1">MEKANLRQELSPVTISSTGNHEAHVSYGVRSLPTPPESSHGGDSRTSYFVNWESNNCPKNKEYSLIHSHCPVLGPTGCTSDFCASGMMFHPLEPHVGENHPLAAIKLEAEAFLHEMFDEGLFTTREDFASRLVEILKEIDSNSLEASVWQASQTVVGDLGAVKVNGWTSSGYTQSREELRFGIRCAWRNSRKCIMRAHYPELKLVDLRSIKTSRGMVDAIVEHAPVAYNGGRILPTVFMFPPRSIKSTGPMFWSPQLLTFAAYELENHSILGDPSNLRLTRDIIALGWNPPEPRSRWDILPIVAMAENEEPAMAILPYELTELVRISHPQYHSLDSLDLKWVKFPALARLGFDIGGVQYTASPFTGWFRTPRLEFATSPIAFDTMSFPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCY7</accession>
    <name>A0A132BCY7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064468.1">
        <property type="nucleotide sequence ID" value="XM_018220598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCY7"/>
    <dbReference type="GeneID" id="28830324"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740507"/>
    <dbReference type="InParanoid" id="A0A132BCY7"/>
    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288094" evidence="2">
        <location>
            <begin position="27"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="666" mass="67409" checksum="A2B3D34E8A8D21A8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCY9</accession>
    <name>A0A132BCY9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_596669</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="18">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064621.1">
        <property type="nucleotide sequence ID" value="XM_018209935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCY9"/>
    <dbReference type="STRING" id="149040.A0A132BCY9"/>
    <dbReference type="GeneID" id="28819661"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596669"/>
    <dbReference type="InParanoid" id="A0A132BCY9"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
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        <location>
            <begin position="544"/>
            <end position="619"/>
        </location>
    </feature>
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        <location>
            <begin position="648"/>
            <end position="759"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
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        </source>
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        </source>
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            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="904" mass="101728" checksum="95E07560445058CE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDD5</accession>
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        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_278679</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="AreA_GATA"/>
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        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="340"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
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        </location>
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        </location>
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        <location>
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        <location>
            <begin position="294"/>
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        </location>
    </feature>
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        <location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDL7</accession>
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        </submittedName>
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        <name evidence="3" type="ORF">LY89DRAFT_787527</name>
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDL7"/>
    <dbReference type="GeneID" id="28832807"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787527"/>
    <dbReference type="InParanoid" id="A0A132BDL7"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="476" mass="50309" checksum="22FAAF5363BAD7C1" modified="2016-05-11" version="1">MSARGVQRGRIERKPVNTTDDATSPTDQTFMLERSNEWPEHLMSSARRLSREFLSPIVHEEQYPRVMSVVSGVDGRRPGLHRIISFAPTATSPTASATSTSSGLNKRQTLPTATVTTLITATLPSEIRGRDFNPLDPLGLGSEFSSLVASRVSVASSVISSGGSGLTSEFPLPSISLPGLPSPSGLLSGNGTSSSSGLLGALGSLLSGGLGSLLSGLAAGLGSSGLTQAIDDDLNRLAFELINGFISDAGIDDFYTLRVLTTCKGESPSNISSCSPFSSAANKISKISSKIPSSLAVVGTNVSSPALNELTGAVSTLGPTADSLEKFLLALMILSLINSAAAIILSFLGIFLAQNRIVITGNLSLATIGIFTRSLDAVLATLISVILSWLTNKFGNSVGLYATSGATFIALIWLGFVFQSLATSYWVCVWFVEFRQSSFRIRKREATEIGDYRGIFREIKIDVRSPKENKEQETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDP3</accession>
    <name>A0A132BDP3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_270036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064464.1">
        <property type="nucleotide sequence ID" value="XM_018206359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDP3"/>
    <dbReference type="GeneID" id="28816085"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_270036"/>
    <dbReference type="InParanoid" id="A0A132BDP3"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="207" mass="23275" checksum="B191A655B25C8BBD" modified="2016-05-11" version="1">MARQRKEKDVKIKLKQPDRSGPDPSQQTLLDIAEKRGLLKIPVGEDEEEREGLDENGEPLIGRLGESVLWSISLTMLHFTLDVLVAHQYAVEIKWNAIVNRSAQAFPIILLLIYSLHSHPTPSPLLPTLPTRIQPLVHQLFFFAGSVAAGCYLIYITNVHSYYAVMKQSPPLGCLWIWSVIELNVFWATGSLICCGIFLKFGGYSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRG0</accession>
    <name>A0A194WRG0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064955.1">
        <property type="nucleotide sequence ID" value="XM_018215877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRG0"/>
    <dbReference type="STRING" id="149040.A0A194WRG0"/>
    <dbReference type="GeneID" id="28825603"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689261"/>
    <dbReference type="InParanoid" id="A0A194WRG0"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="36222" checksum="9806AC5ABFA52BB8" modified="2016-10-05" version="1">MASAPGDPSKRPSSSGQKSSSAPASKRICISPRSNSMAQTRPSPNIESILHLPEDAVWSLRKQDLRACFLVLQQYAKSPYPLPTPTLPSPAIPASFPTEPNNNILSHLLRLPLEIRELIYIHTLPPVCSPPIRGPHPRQLQTHIHLTQPINPSLLLLNHQIRTEALPLLYGAPTQIIHIKIDYNIWEHKTRRSDLILSSALTSSIKHIHVFIHLGSEKRTTKPGDIEADARIAEVKKGIKKLGKWLGGADVQTLKVNWQEPPQTYTWEQKKDILDGMRVLRAVKVDAGEINWGLNWNKGRKFRFEIEYLKELERGSQIEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTF3</accession>
    <name>A0A194WTF3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_595102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065590.1">
        <property type="nucleotide sequence ID" value="XM_018209841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTF3"/>
    <dbReference type="STRING" id="149040.A0A194WTF3"/>
    <dbReference type="GeneID" id="28819567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595102"/>
    <dbReference type="InParanoid" id="A0A194WTF3"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF229">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="57719" checksum="ADB5C7FB2A13DCE8" modified="2016-10-05" version="1">MSLETAVLIRILFTTVVLYITGWIVYCRYFHPLRAIPGPFLASISRSWIVYKTMAADMEHTQRALHKKHGYLVRIAPNEVSCSDPEAIKTIYGVKRLFRKTDFYNAWAPPNNGYVGHFLTRDEKVHSERRRIVNNVYSMSSVLESEEAVNSCSQLLCEIMSEFARQKKEVDLGLWINMYAFDVLGELFYGKMFGFMRDRTDFGGYMKAIDSLLPAFTIGGTLPSYLTKLYLLSTILFSPSVRGALGAIKHIEIASKNAVQKRKQELEEKEDGKHDMLRKMLEISSEKGSKIHFSHEDIYVESHSSLFAGADTTAAAINSILYYLMLNPVAYEKLTAEIDASVISGDLSIPASYAEAIKLPYLKACINEGMRLYPSVGLTMPRLVPAGGASISGHYFAEGCRIGINPAVVHYDKRVYGEDADRFNPDRWIHAPDGCDIPRMDRTMIQFGAGPRTCIGKNISLSEIYKLVPHLVRLFHFRLADPSTGWKTKDYWFNKQTGINIYMEERIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU23</accession>
    <name>A0A194WU23_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_541161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU23"/>
    <dbReference type="GeneID" id="28817906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541161"/>
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    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:arachidonate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
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        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="19950" checksum="9433CB08A5561B84" modified="2016-10-05" version="1" fragment="single">QPAILRSFDRKTDNMLFGECKVWEACRATSAAPTFFDSITIGKRKQTFADGGMIYNNPVEQVYQEAELLWPRQEKLLISIGTGEAPGAAFDGNIGTLINAMKTIVTDSDTKAKDFHRTHHSLAEDNLYFRFSVDQGLASIGLEEYDAKGKIADATDTYISNPEPMRKFAECVKSLKEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU42</accession>
    <name>A0A194WU42_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_226161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU42"/>
    <dbReference type="GeneID" id="28815717"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_226161"/>
    <dbReference type="InParanoid" id="A0A194WU42"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20093" checksum="20CBBE8A59CC8582" modified="2016-10-05" version="1">MADSGTFTCFPRLPPEIRIAIWEKVANLPRNLDIWAPKTGEVTYSAEVHGAPTDKWLETFQYTTTQFPGCLLANQESRSATCKYFELSFEVGYQQDSLMFFYQPEIMSNVTMDRVCPMGWYSDEAVLALWSAETKPSSCAFNVFPPDQVFALEPLLSSPKNAPDEICYTTRKLRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW23</accession>
    <name>A0A194WW23_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_786303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW23"/>
    <dbReference type="STRING" id="149040.A0A194WW23"/>
    <dbReference type="GeneID" id="28832694"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786303"/>
    <dbReference type="InParanoid" id="A0A194WW23"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF8">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="543" mass="60344" checksum="73A67314A74F94A3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW42</accession>
    <name>A0A194WW42_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sphingoid long-chain base transporter RSB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_673967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066541.1">
        <property type="nucleotide sequence ID" value="XM_018213403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW42"/>
    <dbReference type="FunCoup" id="A0A194WW42">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="28823129"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673967"/>
    <dbReference type="InParanoid" id="A0A194WW42"/>
    <dbReference type="OrthoDB" id="3555492at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF7">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="36687" checksum="B2B0AFCAA4C88440" modified="2016-10-05" version="1">MSTPSYIDPTTLTNCTVHTCPVDSSFYNYRISLPPNAIFLTFFSLSLFLYLSIWLTKRRGTFFSSAMLLGITAEIIGYIGRILSYTNQWNENGFLIQTICLTIAPAFFSAGIYVCLAQIVAVYGAENSLIPPRYFARIFIPCDIAAIILQAAGGATSAIALQSNSSLAVGDDVIIAGLALQVYTLFHFILLSMYFAFRVRCRKVRIKTSRRFRGFIWALGIATIAVFWRSVYRVAELNQGWNGPLTHNQWLFVGFEGVLMVIAVAALGVFHPVSCLDGAWGGVKGAQGDERSNGGIEEVRKEGSEMKAEGERRSEPQIPELGMRAEEITPAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWB3</accession>
    <name>A0A194WWB3_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_721923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28828411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721923"/>
    <dbReference type="InParanoid" id="A0A194WWB3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KUJ12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="224" mass="25014" checksum="D217A659D58F1112" modified="2016-10-05" version="1">MAGAGSCLFAKSLQDPVSSDVTDNQAPMRFQSSTTTGRRELLLAPRTAQPLFQLYHGLSGSRNREIFSAAALMLKDVSTLSVSTRSYRDEVVMADFLRVLPGVENLALLFPELFPVRVRPYLDAMKIRVLRSLRLSHCKATASEFVDLCKIHSRTLKELHFQDLSLMEGHVEPFFESISDILLTWEQFTLKGYLVELENETSITPQGLDTPGPQESNLCTTGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWJ7</accession>
    <name>A0A194WWJ7_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">RAI1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_206066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066706.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWJ7"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_206066"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAI1-like" evidence="3">
        <location>
            <begin position="114"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="423" mass="48601" checksum="C1798EF9B2308BEB" modified="2016-10-05" version="1">MTSLNESILSIRPSTLHVQQSSGTSQIGGPTRETNHDATERKTLTKGRQRPSRDDRMLKGVDKLIKNIYNEFSEVQEEACEAVAIRNYESIASYSWKDIEHPTIYVPGLPPKFTPPTLPVQLQRDKLTRSKPRSPAAAVDPLFESLLQQHPNFDMSSIHLVTDRNSLRKLLTFASNRSEKWRIDVDMINNTMFFNQWEEFRLMMINGHQDSGYGHAFENCVTAREPTLEDSIHHERIVRYELGGLECLVRFEADAYLNADGSREHLAIDPPAPKPSRPVLRPPYKLVHVVSRGHYVDPDLIAEIKSCSTLNFNINKTLDQLWFSQTKHLCVGRHKEGLVTEKLEMKDMREELKKWEASNQEHLINMIRVIREIREIAKTTRKCTVICTMIDGVKCLSVFNRKGADMAIRPEVVKRCWRTLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXL8</accession>
    <name>A0A194WXL8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF747-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_699668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066687.1">
        <property type="nucleotide sequence ID" value="XM_018217071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXL8"/>
    <dbReference type="STRING" id="149040.A0A194WXL8"/>
    <dbReference type="GeneID" id="28826797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699668"/>
    <dbReference type="InParanoid" id="A0A194WXL8"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="820"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="862"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="942" mass="105034" checksum="B868D1E461849B50" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXQ4</accession>
    <name>A0A194WXQ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_592377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067065.1">
        <property type="nucleotide sequence ID" value="XM_018209696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXQ4"/>
    <dbReference type="FunCoup" id="A0A194WXQ4">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WXQ4"/>
    <dbReference type="GeneID" id="28819422"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592377"/>
    <dbReference type="InParanoid" id="A0A194WXQ4"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="197"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="359" mass="40816" checksum="6E591ABACDC2F697" modified="2016-10-05" version="1">MSDLPPLPSYTLSPVQPLISFIPDFYLSLMLPIAAYWIVSMFFHIIDVYDVWPQYRLHTPAEILKRNHVSRYEVARDVVIQQIIQTVVGIILGITEPEEVTGREEYDIAVWATRLRIAQRVLPQLLGLLGLNAAAISKNIAGSHPMLAGALAGGKYPSLALGMDALGGSPVPTFASWEVFAAKALYWYIVPALQFWLSILIVDTWQYFLHRAMHINKWLYTTFHSRHHRLYVPYAYGALYNHPFEGFLLDTLGASIAYKVAGLTPRQGMIFFTASTIKTVDDHCGYALPWDPLQHITSNNAGYHDIHHQSWGIKTNFSQPFFTFWDRLLGTMWSGDTKLRYARDRKAAQFKVDADKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXW4</accession>
    <name>A0A194WXW4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_622743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067125.1">
        <property type="nucleotide sequence ID" value="XM_018210986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXW4"/>
    <dbReference type="STRING" id="149040.A0A194WXW4"/>
    <dbReference type="GeneID" id="28820712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622743"/>
    <dbReference type="InParanoid" id="A0A194WXW4"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="45686" checksum="BC62863CFDC8B0F1" modified="2016-10-05" version="1">MSSSKQNILIIGSGWAGSTLATSLDENKFSITVVSPESTTPYTPLLASAACGLYDYSLVETPIRHTGKRMKYIKARVLDIDFKGKNVKCQSVFEDAPTNEFVIDYDIVVVAPGCVNQTFNTPGVAENALFLRNVKDAMKVSSQVQNCFEKASIPGLTEQQQRSLLHFVVVGAGPTGVEVSSELSDLFADTYSKLYPHLNGKVSITIHDIAENVLSGFDSKLQEYAMSSFDKRNVEVLTGSHIEKVEKACLFTKEKGRIECGVVIWATGNKCSPLVETLPVKKTPRNPRILTDDFLRIYTPSSTLIDSAYALGDAADVEDARLPTTAEVACQKASYLAKSLNRGFEKPFRYEQAALVAYLGQNDGVISGKKDYSGAQAWIAWRSKNFLWTRTWRQKVLIVVGWLLDLVTGRAIAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY46</accession>
    <name>A0A194WY46_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative copper-transporting ATPase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_688255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066964.1">
        <property type="nucleotide sequence ID" value="XM_018215669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY46"/>
    <dbReference type="STRING" id="149040.A0A194WY46"/>
    <dbReference type="GeneID" id="28825395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688255"/>
    <dbReference type="InParanoid" id="A0A194WY46"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1132" mass="121533" checksum="BD05801E22AAE22B" modified="2016-10-05" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A194X0B1</accession>
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        </submittedName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19543" checksum="04C42CE27241FEFE" modified="2016-10-05" version="1">MFPSSHRITGRPRKILIRIDYEIDEGTPATATAIISISPYKTLEEMIDEVEDIINKNRFWVQCVGRDPSWAPGQEADRKGKGKAREGDEKEVVLKGYWEFSPVLAMCCEDGASNQVQVKLKSDEDVSAAYGLLESMKWNGYFVLTTARRPERSSSDSPEHLEVYDDAPENPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0T4</accession>
    <name>A0A194X0T4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_622495</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067929.1">
        <property type="nucleotide sequence ID" value="XM_018210976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0T4"/>
    <dbReference type="GeneID" id="28820702"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622495"/>
    <dbReference type="InParanoid" id="A0A194X0T4"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22522" checksum="7D8F9099AAAA3E61" modified="2016-10-05" version="1" fragment="single">MESSSGPKVLVTGFGAFQDIKNNPSWEIVSRLPDMINGVRIIKDSEPLKAVYQSLLEVPKLLEKHNPDVVIHVGLAFDRNYFAIEKGADRDGYHQVPDEARKVVTRAETKARWGMSPARLDTTFNIEDVLAKWKANAVAGSGKGKAKGKEFDLRTSDDVGCYVCGFVYYASLERVLFLHIPDLQGEAEIQRGRDICVALVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X188</accession>
    <name>A0A194X188_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_590803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068094.1">
        <property type="nucleotide sequence ID" value="XM_018209617.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X188">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X188"/>
    <dbReference type="GeneID" id="28819343"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590803"/>
    <dbReference type="InParanoid" id="A0A194X188"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="218"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="957"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1405" mass="159008" checksum="0D63D46EA2EB190F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1J5</accession>
    <name>A0A194X1J5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenolic acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_753166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068209.1">
        <property type="nucleotide sequence ID" value="XM_018221262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1J5"/>
    <dbReference type="GeneID" id="28830988"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753166"/>
    <dbReference type="InParanoid" id="A0A194X1J5"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23551" checksum="099A262BFDAEFD47" modified="2016-10-05" version="1">MSSNVYPTHPITLDATIPLFKKDLEDVHIIYDYDAKNPETGVPEKWQYEIWFSSSDRIVYAIHGGPMAGRVNFQTAGYQCIREGELWQVNWLEETGTICSMVYDITAVPAEGKKGKVTTLIAFSKGHWDNDKGSALGDKRNDPDFYRWHELSKEGTAIDRCLLQEQADVSHAFKGPGDKALYGLDPLVPIEHEWQTIFPPKDGPKLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1Z5</accession>
    <name>A0A194X1Z5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_736858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068217.1">
        <property type="nucleotide sequence ID" value="XM_018220182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1Z5"/>
    <dbReference type="GeneID" id="28829908"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736858"/>
    <dbReference type="InParanoid" id="A0A194X1Z5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="305" mass="34162" checksum="0106495355ECA837" modified="2016-10-05" version="1">MSNVDTQTAEPFDIVDNNEASSPRVHTSTSTQRASPRKLPRIIYYPPPARMRHTLTPTPGAPSRTSQTSPLRQTDFAEIADDDPKLLALIQAARQQLIRDRATRASTIADSAPAMGPDLRPAQFASNAAPDDPSGDSSSDSDRRTHPHFRGPSARRHRGEIPTQLTPAPQIRSIAPALRTNYRFPDPPLFDNGEDSTFDSWIIDLDSKLEASGYMDPSVSEKQRMNYALSRTTSEARAQLLTRFSTTLQRVHHAFRTLEEMVQSLAIAYVDPFESLKKQDEYRSLAMIDTKTVRQFKIRFLTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2C1</accession>
    <name>A0A194X2C1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAPG hydrolase PhiG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_686673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068504.1">
        <property type="nucleotide sequence ID" value="XM_018215339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2C1"/>
    <dbReference type="GeneID" id="28825065"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686673"/>
    <dbReference type="InParanoid" id="A0A194X2C1"/>
    <dbReference type="OrthoDB" id="3335931at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041526">
        <property type="entry name" value="DAPG_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18089">
        <property type="entry name" value="DAPG_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DAPG hydrolase PhiG" evidence="5">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26581" checksum="AD98E3019B277A4A" modified="2016-10-05" version="1">MAAESSPFPLLVSEAKLLLTNPYPPTETGYAVNSEGMHHIAATTYMPNCTSEMIAWWFGWIEDTEKYKLWHPLDHVFSSREGPSNNDSMYIDSHHLVHEYIGGHLAKLKISFVSPEKYFGTEWEEDFKKEGYELAVCARVGNWDDETNEVIYNGHLIHLIKKEKLGVRMRSRFWLGDVEGVEDAQVRMELVPDFLPKGLCQHATEEMTILAGVLPGLYEKFSKKSGDKGELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2I9</accession>
    <name>A0A194X2I9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_784345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068748.1">
        <property type="nucleotide sequence ID" value="XM_018222779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2I9"/>
    <dbReference type="STRING" id="149040.A0A194X2I9"/>
    <dbReference type="GeneID" id="28832505"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784345"/>
    <dbReference type="InParanoid" id="A0A194X2I9"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="67"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="31830" checksum="5E3B54D7250AA6F1" modified="2016-10-05" version="1">MAISHEDILATLLEVQETHEFSIIKLSEPLSGPLKQNPGERTSDVSADVFDNPTPASLEEDLSHYKELFSKLRFSYLEQVTKEKFIRAIVGDPPLVVEHQENVELEETLAVSKAGLKSQKTEVAELVAELEKRGRELCRKYQNIQMQTSQLQELPQRIEELEASVEELRAAQQPGSNPTLNMPLDKTLDLVEQRERERVELDRQLEQLQVMLPRKTKELERLNAELQPLEVKRLGSTASAREAKRRKEEALGGVGDDLEERGRWWRGVESGLKGMLGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3E3</accession>
    <name>A0A194X3E3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_119526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069041.1">
        <property type="nucleotide sequence ID" value="XM_018205135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3E3"/>
    <dbReference type="GeneID" id="28814861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_119526"/>
    <dbReference type="InParanoid" id="A0A194X3E3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="25442" checksum="83C2D941D0C17C37" modified="2016-10-05" version="1">MPQRKVYITSPHSQYPRNFHLPHHPTYKQKMATNTKPTPSTTSNLSATATIFDPLSSLKAELAAAEAHLTNLKASFSHAIYAALGEESCCDPIEEYLAIKTHDRLVATQLFHLEEEREQIRQWKEWNEIEKILEIGRESFRAEMKMEDVQSITIGFETQFEEIEREQKLLIECGEQVQVSDEEMKEYHRVQERKFLGNKMKVKLADSIARRARLAHGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3U7</accession>
    <name>A0A194X3U7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_784435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068857.1">
        <property type="nucleotide sequence ID" value="XM_018222788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3U7"/>
    <dbReference type="STRING" id="149040.A0A194X3U7"/>
    <dbReference type="GeneID" id="28832514"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784435"/>
    <dbReference type="InParanoid" id="A0A194X3U7"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33691" checksum="037380421285B9AC" modified="2016-10-05" version="1">MLPSTDDSVLEDTIGAQLDSEIASLKAQVQTLKTQRKTQSTTIISSRTTQTILSRLRASQKTTSTRSSQETDISPLLSTSTAQLAHNQENLYRSCAGITTFRIRDPDPNAVDDGNVLGIRFDVSTSGKFVRPYYVMLNKPWAGKTLLRIHRHTVPSCIPLASLADRYLPHGKGAAAMGDKESGAKRQDLTRFVRALRREIVGYHNRVSVIKGLRKEFKLDEKVSRKGKERERVIADISVADAEAKQVRIEWVDGRIGRAVVDDKGDVKKCVVIGEEGRDREVERRVCAGGMEGIGERLREGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X477</accession>
    <name>A0A194X477_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_783722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068977.1">
        <property type="nucleotide sequence ID" value="XM_018222714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X477"/>
    <dbReference type="STRING" id="149040.A0A194X477"/>
    <dbReference type="GeneID" id="28832440"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783722"/>
    <dbReference type="InParanoid" id="A0A194X477"/>
    <dbReference type="OrthoDB" id="5430054at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="525"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="914" mass="104914" checksum="A4C8411D3F0AEEC1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4X1</accession>
    <name>A0A194X4X1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_670724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069578.1">
        <property type="nucleotide sequence ID" value="XM_018213183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4X1"/>
    <dbReference type="STRING" id="149040.A0A194X4X1"/>
    <dbReference type="GeneID" id="28822909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670724"/>
    <dbReference type="InParanoid" id="A0A194X4X1"/>
    <dbReference type="OrthoDB" id="3432186at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="314" mass="36263" checksum="77E0DFB4C17431AC" modified="2016-10-05" version="1">MRLLQYNNDGDFSLIEFNESDIPEYAILSHTWEQDNSKEVTYAEVISGTGQNKDGFKKINFCGEQARQDGLPYFWVDTCCINKQNKAELRHSINSIFRWYRNASRYYVYLSDVSTRKRKASDQSSEHNWDLSFREKTGKEEDKAYSLLGIFGVSIVPTYGEGVAKAFDWLWNRFREIQKCMQDLRPTDPRLDKQRIEATKGGLLQEAYRWVIETSDFQQWRTNQHHRLLWIKGDPGKGKTMLLCGIADELQNSLAKSALLSYFFCQATDSRINRATAVLRGLIYLLVDQQPSLVSHVQASYDEAGKALFEDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X521</accession>
    <name>A0A194X521_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative protease S8 tripeptidyl peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_108206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069636.1">
        <property type="nucleotide sequence ID" value="XM_018205054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X521"/>
    <dbReference type="GeneID" id="28814780"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_108206"/>
    <dbReference type="InParanoid" id="A0A194X521"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267901" evidence="9">
        <location>
            <begin position="19"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="230"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="687" mass="74062" checksum="53DC3D7DE469A536" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X679</accession>
    <name>A0A194X679_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase-like protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_647575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070040.1">
        <property type="nucleotide sequence ID" value="XM_018211964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X679"/>
    <dbReference type="GeneID" id="28821690"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647575"/>
    <dbReference type="InParanoid" id="A0A194X679"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="31267" checksum="453A29C22EA8B3AD" modified="2016-10-05" version="1">MVSTESLRAEKLFSAKGHVCVVTGGGTGIGLMATQALAANGAKVYITGRRMEALENAAKSHSPSQGGEIIPVGPCDVTKKSDLENLVSQISKKEKHIDLLICNAGISGPKAEPESADAEELKERLINSESFEEWSDTFNTNVSAVYFTTVSFLPLLQAAHSINGALSSSVIVISSMSGIMRHAQGHFGYNAAKGATVHLSKLMSYEFKKAGIRVNSIAPGYFPSEMTTKESDEKQKSEMPQSKIEEKGHVPMNRAGSDEEMAMGVLFLMKNKYVNGEIIAIDGGVLLEVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6K9</accession>
    <name>A0A194X6K9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_647809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070158.1">
        <property type="nucleotide sequence ID" value="XM_018211974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6K9"/>
    <dbReference type="STRING" id="149040.A0A194X6K9"/>
    <dbReference type="GeneID" id="28821700"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647809"/>
    <dbReference type="InParanoid" id="A0A194X6K9"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="396" mass="43841" checksum="DD3E06FD8D4058A1" modified="2016-10-05" version="1">MVVFLDLEDENEPPEQVRNHWFMQQQHGNAALLRGLSLRGQDGEDDGRENPNKTKAVTQAMGCYPIIASIASHIDLNTIDALSLTCRQVRANLLQFRNQLIISTLHCENEDIEPDPEHTFRYRARAADWYFVEGGREALGTGAGKFGDCARDLVGQCRRCNRVVCRNCTIKPPAPILLRHRHRRICTACSRKPLSSLVHPTSSTHDPTPLSAETLNREICTCPDSVWLCQPCGRSLRSSDVEYESIWKWRTRYLPSLGGLGVGIGEGNRGVPCGRGRECVAAKEVESEVDCDAEDARDSNNASPSSSPRSSGIVRNGTPSQMGPGYARHEIEGIGGRVKTKLVRMVKVGCCVPEFEIEKDAGKFLVREQEGLARSWCGWCWRVIPCVKDVVGGGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6L5</accession>
    <name>A0A194X6L5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 54S ribosomal protein L22, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_685746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070163.1">
        <property type="nucleotide sequence ID" value="XM_018215142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6L5"/>
    <dbReference type="FunCoup" id="A0A194X6L5">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X6L5"/>
    <dbReference type="GeneID" id="28824868"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685746"/>
    <dbReference type="InParanoid" id="A0A194X6L5"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="325" mass="37867" checksum="1FF2E6E3C0868D32" modified="2016-10-05" version="1">MSLHLPSRRVVRSATALINPQNPLSFLTPCIQKRTAFWDWSRRNELPDATRRPQNPLTEEYLKKKPKVQPPTRGDLAESSIFEDEEIAGPKPTAITKDEKGVEQKQLVRNPDAMAAALDPDPRGRQRWERKMVIREIHKRGRLTRVQQLKKEERVVLSKSHDFKTSVKKLMPLARQIAGKTVEEAIIQMRFSKKKVAKDVREHLEHAKNEAIVRRGMGLGIKDQDFTPVQIQTKDGKRVKVRDPTTLYVDQAWCGKGLFQQTPDHRARGNIFLMKNRTTSLSVVLKEEKTRIRLHEDRLKKEQKKKVWVQLPNRPITAQRQYYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7D3</accession>
    <name>A0A194X7D3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_783236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070354.1">
        <property type="nucleotide sequence ID" value="XM_018222659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7D3"/>
    <dbReference type="GeneID" id="28832385"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783236"/>
    <dbReference type="InParanoid" id="A0A194X7D3"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="363" mass="40303" checksum="D337DEFECE29B072" modified="2016-10-05" version="1">MAIWGMISALQATTHSFVGELLCRLFLGAAEAPFFSGCIFLMSSWYRADELAHRIAILYTGVAMANMFGGLIAAGVLSDLNPAHGIAGWRWLFIIEGAATSGIAIIAVFFMPDYPATTRWLKTEEKHYAQWRLAQDVAGEQDDRNAITWKQALKMAFSDWRLYLFMLMHHSNLLAQSFTYFFPTIVNSLGYGKIETPFLTVPVWFATLLATLLVSYHSSKTRERSFHIAACMLVGALGNILVITTHGVGPRMFAMYLMPIGILPPFQMILAWITSSFPRPLGKRAVVVATCGMFGNAAGIYGSYMYPPSDGPQYVPAGIGLAVVCCFCATMAIVIRFVLKRENKKLEKQEQEQGLRAGFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Y7</accession>
    <name>A0A194X7Y7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070579.1">
        <property type="nucleotide sequence ID" value="XM_018215055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Y7"/>
    <dbReference type="GeneID" id="28824781"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685256"/>
    <dbReference type="InParanoid" id="A0A194X7Y7"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23841" checksum="3BA500F23D49A661" modified="2016-10-05" version="1">MALYPPTTSPHTSPSSPVTSSLVPPIPVPTHGSKGTFAVLSKAIIPATPIEVLTLIRDTNTWPLWNTFCPACVISPRKTPIPKCGDLETGKEGWLELGSEATIDVHMEGDGLVEGSTRSRTQGLVVTRLEKIGEDGRKAFRIAWKGVGYSHWQLHSERVMEMVEVEGGGTDYVCWETFGGMLGSVVKMMVGAQLVDRFGDYSRDLREHFEKAKKGVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8C0</accession>
    <name>A0A194X8C0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_782627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070714.1">
        <property type="nucleotide sequence ID" value="XM_018222597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8C0"/>
    <dbReference type="STRING" id="149040.A0A194X8C0"/>
    <dbReference type="GeneID" id="28832323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782627"/>
    <dbReference type="InParanoid" id="A0A194X8C0"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="537" mass="62002" checksum="4F8FF2B3687928C1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9A5</accession>
    <name>A0A194X9A5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_645645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071105.1">
        <property type="nucleotide sequence ID" value="XM_018211891.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9A5"/>
    <dbReference type="GeneID" id="28821617"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645645"/>
    <dbReference type="InParanoid" id="A0A194X9A5"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="93652" checksum="6F9481101D8DFBFE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCN0</accession>
    <name>A0A194XCN0_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_582814</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="149040.A0A194XCN0"/>
    <dbReference type="GeneID" id="28818909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582814"/>
    <dbReference type="InParanoid" id="A0A194XCN0"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30231" checksum="B391DE19044DB2FD" modified="2016-10-05" version="1" fragment="single">LFDIGGVCVVSPFQAILDYEISHGIPPGWINYTISRTRPSTWHLLERNEIPVSTAFYTSFTRDLTNASLWPTFYALALSRDPSLPPTTPPVPSVDGEELFWKMMDKSRTLDPWMYPALLALKESKKYILAALSNTIIFPEEHPYANPAPEKDVRRLFDVFVSSAHVGLRKPDVRIYELALEMVNDYAQKEGKLGEGKGIEAGDVVFLDDIGENLKTGRMVGFRTIKVKLGRAFEAVDELEEVTGMRLAGDHPRVPVLPVVNKKGREEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCX8</accession>
    <name>A0A194XCX8_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_746067</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCX8"/>
    <dbReference type="GeneID" id="28830811"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746067"/>
    <dbReference type="InParanoid" id="A0A194XCX8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="34640" checksum="36643D4D99A63894" modified="2016-10-05" version="1">MLMLLVPSFRRRLNPLNSSSSADGAGSCSTGIVLDLDDPPSSGEATWEKGTHKPCQPRTRAPAGVDPFQTSWSGWKVHREEEDEEATRDQQTGTGGRTIAGSVEDPGEDDEGHKGHKGRSRIGVRPVLCSHEWGRPGMGLDGVGLVWMVVMLDSPSQDQCSSRFGTLSILAILEGVGGGGGESAEPYGDVPHGMGMGLDGMGWDWIVWAAARAAAWPRVTLYSVRVWSGKTWTGTGTMDMHRHGSWSRKRSSLHCDHDLGPCASHSHPPHLTTPYQARPYRTSILPLKSGSSIICIIVRDPRCAHWPAYGKDDDSLPTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDQ0</accession>
    <name>A0A194XDQ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_29113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072232.1">
        <property type="nucleotide sequence ID" value="XM_018206517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDQ0"/>
    <dbReference type="GeneID" id="28816243"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_29113"/>
    <dbReference type="InParanoid" id="A0A194XDQ0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="514" mass="58962" checksum="AA92B2AF76557799" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDY2</accession>
    <name>A0A194XDY2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072750.1">
        <property type="nucleotide sequence ID" value="XM_018214848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDY2"/>
    <dbReference type="STRING" id="149040.A0A194XDY2"/>
    <dbReference type="GeneID" id="28824574"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684299"/>
    <dbReference type="InParanoid" id="A0A194XDY2"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000171">
        <property type="entry name" value="Glycosyl transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35724" checksum="B501C139B18BD96C" modified="2016-10-05" version="1">MAEAKRRVTESKKVWTTLITNTAYLSGLLTLDYSLKKHGSKYPLVALYTDTFPAEGHAALEARGIPKQRIEYLLPTKGKDYSADPRFYDCWSKLAPFSLVEYDRVVQLDSDMLVRRNMDELMEMELDGPELEGKGMKVFAAGHACVCNPLKKKHYPTDWIPSNCAFTSQHTTPDIAQTTGPDPAVGPLGFMNGGLQVVNPCTAVYNQIVSYMESDAANMDFADQSLLSDLYKGRWVPLPYVYNALKTLRWEGVHSEIWRDEEVKNVHYILAPKPWDEMDAEGKNISKDFTHQWWVDVNNERLAVEKEKGVSKDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE24</accession>
    <name>A0A194XE24_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_47757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072759.1">
        <property type="nucleotide sequence ID" value="XM_018207819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE24"/>
    <dbReference type="GeneID" id="28817545"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_47757"/>
    <dbReference type="InParanoid" id="A0A194XE24"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="708" mass="79088" checksum="9A235586868E5376" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEI8</accession>
    <name>A0A194XEI8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-dependent flavin oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_642992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072960.1">
        <property type="nucleotide sequence ID" value="XM_018211777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEI8"/>
    <dbReference type="STRING" id="149040.A0A194XEI8"/>
    <dbReference type="GeneID" id="28821503"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642992"/>
    <dbReference type="InParanoid" id="A0A194XEI8"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="443" mass="47905" checksum="E20D12ED16010017" modified="2016-10-05" version="1">MGSTATPQNTAAPNAPYFTPIQSPPAGTALSDNPPTLFSPLKIRDVTFQNRIWVAPMCMYSADKGHLTDFHLVHLGAFAYRGASLTIVEATSVLANGGITPQDAGLWTDSQIAPLKRVADFIHSQNQKIGIQLAHAGRKASCIAPWLVERGKALTATEDVGGWPDDVMGASAIKWGEGYPSPREMTSQDIKDVINGFRDSARRSVEAGIDVIEIHAAHGYLLSSFLSPTSNKRTDAYGGNFENRIRILIEIITSIRAVIPEGMPLLVRVSATEWLEESDEPESWKVEDTIRLAKLLPALGVDLLDVSSGGNNEKQRITPFNDFQVGIAGQVREALFAAGVKDLLIGAVGMITEAEAAKAIVENGKALREAGSGMGDSEGTEGAGKVIEIEDEQGAKAKADIVLVARQFLREPEWALRVAYRLGVKVQWPQQYHRGQFVKGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEJ5</accession>
    <name>A0A194XEJ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_684117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072532.1">
        <property type="nucleotide sequence ID" value="XM_018214817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEJ5"/>
    <dbReference type="STRING" id="149040.A0A194XEJ5"/>
    <dbReference type="GeneID" id="28824543"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684117"/>
    <dbReference type="InParanoid" id="A0A194XEJ5"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="465" mass="51571" checksum="4C4F1E828FD7D42B" modified="2016-10-05" version="1">MASKLKPLSRLTNSLRPYIRSTNIQPRSFSACPSYRTDGVYRELTAMRTRVPFIEAFRKQQNEGSQSSPIPTEKVERDLSPKSMSDSHTRIILPLARDPWLLDSYINSSGHIRLGTIFMDLDALAGVIAYKHTGDSVMTVTAAVDRITLKQPLNQICDLELSGRVTFATGRSSMEVSIQVAKAPEEGKEVEGADVLMTCAFTMVSLDPATKKPVNISPLKTNTPEEKAIFDQGEANYNLKKSMQSQALRKQTPNDEESDLIHALWLAQLDYHNPNTPARKPSSALYMKSTQIHSTQIMQPQYRNRHNFMIFGGFLLKSTFELAFTCASSISHTRPTFIALDPSTFLHPVPVGSVLYLTATVAYSDSPLPSLAQFSPNPSISPDPKTSPKGSSRIQIRVDSKVRSIEGGETKPTGTFNYTFQVGRELQVVPETYGEFMMFLDARRRGLVVNRSLGEGEGRKGGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFG2</accession>
    <name>A0A194XFG2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073229.1">
        <property type="nucleotide sequence ID" value="XM_018219679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFG2"/>
    <dbReference type="GeneID" id="28829405"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732413"/>
    <dbReference type="InParanoid" id="A0A194XFG2"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="633" mass="72801" checksum="5821C32964308D1E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGP2</accession>
    <name>A0A194XGP2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_731740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073693.1">
        <property type="nucleotide sequence ID" value="XM_018219605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGP2"/>
    <dbReference type="STRING" id="149040.A0A194XGP2"/>
    <dbReference type="GeneID" id="28829331"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731740"/>
    <dbReference type="InParanoid" id="A0A194XGP2"/>
    <dbReference type="OrthoDB" id="5418627at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="601" mass="64797" checksum="363BB14DFC21CFB4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH51</accession>
    <name>A0A194XH51_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_546268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073890.1">
        <property type="nucleotide sequence ID" value="XM_018208248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH51"/>
    <dbReference type="STRING" id="149040.A0A194XH51"/>
    <dbReference type="GeneID" id="28817974"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_546268"/>
    <dbReference type="InParanoid" id="A0A194XH51"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19571" checksum="859A8B21A1FE533C" modified="2016-10-05" version="1" fragment="single">SSSRDLSDEIDRLLETYLSLLDQYTTLRAQLSAQQISTQQNLARAKFHAPLGVHYGESMYDGRMQAQRRCVCRETTTLDIVAVESAACSEEGDTTSAGNENGVQEKIARRDPIRMFGLLVPEALRRAHGDAVVMVERIVPEICRVDREMGELEIRIRRARKYRAKAEEREMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH64</accession>
    <name>A0A194XH64_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">LY89DRAFT_491627</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073836.1">
        <property type="nucleotide sequence ID" value="XM_018207902.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XH64">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XH64"/>
    <dbReference type="GeneID" id="28817628"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_491627"/>
    <dbReference type="InParanoid" id="A0A194XH64"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990530">
        <property type="term" value="C:Cdc50p-Drs2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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            <begin position="1239"/>
            <end position="1258"/>
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        <location>
            <begin position="218"/>
            <end position="284"/>
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            <begin position="1"/>
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        </location>
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            <begin position="86"/>
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        <location>
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    <sequence length="1347" mass="150582" checksum="B9F6B12FEB49DD1A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH76</accession>
    <name>A0A194XH76_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
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        <name evidence="2" type="ORF">LY89DRAFT_491530</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_491530"/>
    <dbReference type="InParanoid" id="A0A194XH76"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="229" mass="24861" checksum="29035E911494465A" modified="2016-10-05" version="1">MTAPPSPPPLQLTSPRLTLELFSRSNPAHYALMLGVINNPIAHATMGDYGIRTASQLDALNQATFLRSPISFPQELIYILQLHLKSDAETETETMIGAVTLAQRSSTIPPDIGWALLPAYMGKGYATEAAGELLRWVRESWGVGVCTWPDERNGGSVRVAEKLGFVDGGFVRSVDGHGEVRDEDEGRVDGGGELIRTWVLPGMRRLDEGGVVEISFWGEQGGGMRARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHC3</accession>
    <name>A0A194XHC3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD and RING finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_494158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073918.1">
        <property type="nucleotide sequence ID" value="XM_018207919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHC3"/>
    <dbReference type="STRING" id="149040.A0A194XHC3"/>
    <dbReference type="GeneID" id="28817645"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_494158"/>
    <dbReference type="InParanoid" id="A0A194XHC3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67709" checksum="30E1371DD7D02B2A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHM4</accession>
    <name>A0A194XHM4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_640903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074070.1">
        <property type="nucleotide sequence ID" value="XM_018211686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHM4"/>
    <dbReference type="STRING" id="149040.A0A194XHM4"/>
    <dbReference type="GeneID" id="28821412"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640903"/>
    <dbReference type="InParanoid" id="A0A194XHM4"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22359" checksum="3275F070A953E96D" modified="2016-10-05" version="1">MAATNYEAAISLIDEAHAQDPKITIVDGHDVPYELHYAQKMTHYLEQRAPDASPILKVAIRAQHFRRWEIPRDSYPMTKVGYLNWRTFLKKRQADLASAICIGCNFTTEEAEEVAKLIRKEDLKKNEETQILEDVACLVFLDDQFDAFEKEHDEKKIIDILRKTWGKMSEKGHELALKIPMSESSKELIGKALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHV3</accession>
    <name>A0A194XHV3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Exo-beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_731753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073707.1">
        <property type="nucleotide sequence ID" value="XM_018219608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHV3"/>
    <dbReference type="STRING" id="149040.A0A194XHV3"/>
    <dbReference type="GeneID" id="28829334"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731753"/>
    <dbReference type="InParanoid" id="A0A194XHV3"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268268" evidence="6">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="99"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="48085" checksum="C2350E7206B0B844" modified="2016-10-05" version="1">MIFSTSVALLLAAQAVSANPLKSEKRQFPPGIGFNWGSEKLRGVNIGGWLVLEPFITPSIFQSLDQSLGIQDEWTLGQQLPGQAPGILQNHWDTWVGLSDFQKIADAGFNLVRIPIGFWAYDNANTPYVSGSAPYLDNAIGWARQTGLKVMIDLHGAPGSQNGWEHSGQAMANPGWLVDGGAYGPTSQRTLNVLNTIAQKYADPSYHDAVVAIELLNEPKGWVLNRADLRQFYREGYGRVRQVSDTVVVLHDTFFAPESYNGFMTPQDLNVQYVALDHHYYQIFDDYSVGLLPWQHRQLVCNSADQYWGADKWTFVGEWSAAMTDCAQYLNCYYGGARYDGSLDGIYHGSCAGMSTISSWDQEYKDDTRQYIEGQMDAFESQSQGWIFWNFKTETAQEWSLFDLLDNGLFPNPVTDRQFPPMCDQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIB5</accession>
    <name>A0A194XIB5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_731207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074320.1">
        <property type="nucleotide sequence ID" value="XM_018219551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIB5"/>
    <dbReference type="GeneID" id="28829277"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731207"/>
    <dbReference type="InParanoid" id="A0A194XIB5"/>
    <dbReference type="OrthoDB" id="3531544at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="26640" checksum="01747C060A5BDC84" modified="2016-10-05" version="1">MAGSLLGDMDGQAQGAYRDYDAGAVSIYADTLKSIQTATETALSRPLEVRAITCPAHFFEGEPIFNLRLAASSPRLRYFPDDDDDDDDDAYDQIVALYNAARLAHHLDNCKMFGGQEGCDIFSEDNFALHLKNPASEYFQQVASAIQGFMDEMIVKMTEYYGIKDSKLKVRGVILAGEASREGMEGFKEIIEASLPEYKGRFMFDVDPSLIGAKGAAHRARQWALKMAFVKPRGPFHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIX2</accession>
    <name>A0A194XIX2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_682873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074431.1">
        <property type="nucleotide sequence ID" value="XM_018214588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIX2"/>
    <dbReference type="FunCoup" id="A0A194XIX2">
        <property type="interactions" value="897"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIX2"/>
    <dbReference type="GeneID" id="28824314"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682873"/>
    <dbReference type="InParanoid" id="A0A194XIX2"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000061">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="51814" checksum="A1080612E8F406C6" modified="2016-10-05" version="1">MSAKKRGAEVARGGVQLKTPKGTVDSFGKEVILREQVTSKISDIFRRHGGNPLDTPVFELKEILTGKYGEDAKLIYDLQDQGGEACALRFDLTVPLARWVAMNNVTQVKRYHIGNVYRRDQPAIARGRLRAFQQADFDIVGQYDPMIADSEILRIIVEVFKSLEININIKMNHRRILDGLFVVAGVPEEKVRAISSAVDKLDKLPWAEVKKEMVGEKGLPEEVADRIGEYVQHSGNIDKMLQYLRADATLCANESVKEGLADMELLATYLQAYGITDRVIFDFALARGLDYYTGLIYEIIFQPTAAEAATIQVGSIGAGGRYDNLVGMYGRRTAPCVGISFGVDRILSILKAQRTSESQLQTEPVEVYVMAFGSKDFGGLLPERMAVTAQLWDGGIRAEFMSKVKPKLPNQFKAAVDVPIAVILGEDELKEGKVRVKALGLPDGHPEKEGVLIQKSELVAEVQKRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ47</accession>
    <name>A0A194XJ47_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074501.1">
        <property type="nucleotide sequence ID" value="XM_018219569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ47"/>
    <dbReference type="GeneID" id="28829295"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731375"/>
    <dbReference type="InParanoid" id="A0A194XJ47"/>
    <dbReference type="OrthoDB" id="5426982at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="77574" checksum="6312D46956C524C0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ98</accession>
    <name>A0A194XJ98_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_639558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074588.1">
        <property type="nucleotide sequence ID" value="XM_018211628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ98"/>
    <dbReference type="FunCoup" id="A0A194XJ98">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJ98"/>
    <dbReference type="GeneID" id="28821354"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639558"/>
    <dbReference type="InParanoid" id="A0A194XJ98"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="85" mass="9413" checksum="6771B7B20CF949E1" modified="2016-10-05" version="1">MGQKDDLATDPQCHARACAIQTCLAKNSYNEGACRSEIDALYDCCNAFYSNNGDDAKSVSCPKASLLRLKMRQRMDENRETGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKX3</accession>
    <name>A0A194XKX3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_771813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075136.1">
        <property type="nucleotide sequence ID" value="XM_018221895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKX3"/>
    <dbReference type="GeneID" id="28831621"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_771813"/>
    <dbReference type="InParanoid" id="A0A194XKX3"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443898" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="506" mass="55804" checksum="92DDAB54F6B3E0A8" modified="2016-10-05" version="1">MQLHLVTFAVGLLFQAVVSVAAPPSAQELAAFLRGKRSFEERDGVKRTIFEHRATSSKMDFVENSGVCETTPGVNQYSGYFSVGGTKNMWFWFFESRNDPKNAPLAVWINGGPGCSSMIGLFEENGPCQFYNGSSTPSLNPYSWNEYANMLYIDQPVGVGFSYDSAASAPTVVSAPFVWTFMQAFYAQFPQYENRDFGLFTESYGGHFGPGKFSQLFHFSNSAIKAGSVTGQNIDLVALGINNGCYERLILEKSQIDYLYSNSYYPLINASTHASLLHVLETNATAPLEKCANGGTDAECVFANVNCILNVDNPMGEAADPNSTLDWYDIRQHGNNTVPPSTYINYLSDPAIMKAIGAQINYTECPNPAHDLFSSTGDPEARSQLPELSAVVQSGVQTVMFAGDADVVCNWFGGLVVADSLDWHGKKEFGSKKVENYTVDGAVGGTFKNVDNLSWLRVFNAGHEVPYFRKWPWIEEMRVVLTVHVEPALALQVFKQTMQKKALRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL19</accession>
    <name>A0A194XL19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_578206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075228.1">
        <property type="nucleotide sequence ID" value="XM_018208932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL19"/>
    <dbReference type="FunCoup" id="A0A194XL19">
        <property type="interactions" value="1078"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL19"/>
    <dbReference type="GeneID" id="28818658"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578206"/>
    <dbReference type="InParanoid" id="A0A194XL19"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="156" mass="17802" checksum="1E2E28040727F8ED" modified="2016-10-05" version="1">MSLVSAEKSNFQFILRLLNTNVDGKQKTLYALTKIKGVGRRYSNLVCKKADVNLDKRAGELTSEELERIVTIIQNPTQYKIPAWFLNRQRDIVDGKDSQILANGVDSKLRDDLERLKKIRAHRGLRHYWGLRVRGQHSKTTGRRGRTVGVSKKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNK4</accession>
    <name>A0A194XNK4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxyproline-rich glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_681223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076185.1">
        <property type="nucleotide sequence ID" value="XM_018214235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNK4"/>
    <dbReference type="GeneID" id="28823961"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681223"/>
    <dbReference type="InParanoid" id="A0A194XNK4"/>
    <dbReference type="OrthoDB" id="5398371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53947" checksum="6D224D7CB6EB83EC" modified="2016-10-05" version="1">MATQSEENQPTLVEIRSTGDILLDVHFKNTSECTKSIPKDALRSLRTRKLPIPSPRILYRVRLDTLKKHSEYFRIMLKPQFAEGLAVEKALKDLADASQVASELEPEKLPRVSIIDEDTATKTFGREAVFRDMLRIIHGADPITSPITTQFLTVLVLMADHYNVTSTVSRHMQKVLVAHKYPITLDKNGEEILRQRVLIQFHTDQGIRFANSTKDLILKGSTRWTGMEDLRTHEYQASWWDLPSGLEAELTYRRTCVLRTIASIQTQYLIIYSSKERQCKLGYDSSASCDSFQLGEMVKFLTRKGLLSLVPFQAVSPEDPEYIWPEAYSGDIEYLIGVLRQCPSYQIDHNHGHCGLRTRLLPALDYIKSCIDTGLGIKLNRSKTGPAFESWIPSTSVPRKKSFWVSGKDGEDVDVGGYKAKEFEFVPSRSKTTLGGGGRSVERTPKGLFTAEKWNWVNEPETPMMRTGPTLDLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNY2</accession>
    <name>A0A194XNY2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_608592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076305.1">
        <property type="nucleotide sequence ID" value="XM_018210500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNY2"/>
    <dbReference type="FunCoup" id="A0A194XNY2">
        <property type="interactions" value="1391"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNY2"/>
    <dbReference type="GeneID" id="28820226"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_608592"/>
    <dbReference type="InParanoid" id="A0A194XNY2"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="47068" checksum="1DCB026B627B0155" modified="2016-10-05" version="1">MNTQVTPSKTAASAIEGLKMGDSPAKKLDFHAAGKENLPVSVNAPIVDDIEIKKPIVEEVKFEKSVVVAPTIKPDESDEPLLQENPQRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLSKDLHDWNNKLNDDERYFISHVLAFFAASDGIVNENLVERFSGEVQIPEARCFYGFQIMMENIHSETYSLLIDTYIKEQAQRTYLFNAIETIPCIKKKADWAVKWIQDKNSTFAQRLVAFAAVEGIFFSGSFASIFWLKKRGLMAGLTFSNELISRDEGLHTDFACLLFSHLKHRPSKQAVQDVITEAVEIEQEFLTEALPCALLGMNSNLMKQYIEFVADRLLLALGNEKVYKSANPFDFMENISLAGKTNFFEKRVGDYQKAGVMAGTQKKHEDTTAQTEAKAENGGDFNFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNZ1</accession>
    <name>A0A194XNZ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_639440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075807.1">
        <property type="nucleotide sequence ID" value="XM_018211622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNZ1"/>
    <dbReference type="GeneID" id="28821348"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639440"/>
    <dbReference type="InParanoid" id="A0A194XNZ1"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="12592" checksum="97F9E92E7B5761B9" modified="2016-10-05" version="1">MSATAQIASKRTSNRYSTLSTAPSVATVHTTLSSASAQQEIKDIEDGLDKLENKKLGAQRFVPSVEKTEHLSKLALGAKLERALNRRMGGQDAVMRERKPKLSEKRDEEKVAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-05-29" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNZ4</accession>
    <name>A0A194XNZ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_388678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076263.1">
        <property type="nucleotide sequence ID" value="XM_018207166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNZ4"/>
    <dbReference type="GeneID" id="28816892"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_388678"/>
    <dbReference type="InParanoid" id="A0A194XNZ4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="89" mass="9801" checksum="C8566A68FE378335" modified="2016-10-05" version="1">MLPPLTPPITCQVQGPSSNHNKGHLLLSPATLMLLYYSNLSWKTIMFLYPRLHAIESSLGMISLGCRPSIILQAGLLLTFYSSTLNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPH9</accession>
    <name>A0A194XPH9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_715133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076510.1">
        <property type="nucleotide sequence ID" value="XM_018218182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPH9"/>
    <dbReference type="GeneID" id="28827908"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715133"/>
    <dbReference type="InParanoid" id="A0A194XPH9"/>
    <dbReference type="OrthoDB" id="5430057at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="445" mass="50360" checksum="AA2BE3A49E82A5F9" modified="2016-10-05" version="1">MQEYTSSRIPMLLVDIAVGCFVALLVMLLSAIIFIIIPFRKFYGLPKPRLDFDESKNLLPIEEKRRDEPAFSTLALFRSSDLSLDKAKEQYDANPVTYARELWRISIQLQRVLLDKNEKGLSCLLQKQSHDAKRRNRASEGATGLWIRISLFESLEWAIADFRIKRCEKAMAVANRKASAGASTTNTNRLAVSMDGDVELGTIPPTTTNTPVRIDWISEYQTFALNVNLFCDTVSVHAIDHLSPAWDTLTDLYNSAAKRRPDISLVKENQELRGQVQSSKRAIAALQIRRAIDKLTFELPKTAHYSYGVPKKIPKKVAAGYVPADDGAGRVTQRWGKLWGDIWDAAETDEKSLFYKSRQDAKGQHEKQNLKKKGEELFSDMSAEIHGYNKRDQDYAQFDPATNAIAKILLKSLVVDEDSGEVDWKETIRKYPVVGREKREDGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQH9</accession>
    <name>A0A194XQH9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_293389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076669.1">
        <property type="nucleotide sequence ID" value="XM_018206530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQH9"/>
    <dbReference type="FunCoup" id="A0A194XQH9">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="28816256"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_293389"/>
    <dbReference type="InParanoid" id="A0A194XQH9"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="342" mass="38667" checksum="C677AF4A88640909" modified="2016-10-05" version="1">MEIEPRSLAVSKSNGVEVLRNLLGFGAGEMIDAIFVAIDFEGCQNIENAFQTSIDSEFGVAYLDTRDLLHHEEKDPSSFITTQEFATGSNSRFDKAVKNFRFGVAERVSIYDLGEKIRQCLNPQDADITNEKRKVIIVRHWRNEMRSVEALRIFSHDLRCVHRILDISRTANELFERPPGCPIGLTKLSSDLSLPFRGEDFHTAGNDANCTLRVLLMLAVKSQENIIPEGPQSKLVALLRQIAQAPLPPTKSEEEVNRLLAMQPTEPLDDAAQPVDMSRFYVKLTKASLRQRFTQRRQEKDNDPEERARRAAIRANRDLKEDGENFMGALQQLEIRVSNAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQZ9</accession>
    <name>A0A194XQZ9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_729624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076512.1">
        <property type="nucleotide sequence ID" value="XM_018219395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQZ9"/>
    <dbReference type="STRING" id="149040.A0A194XQZ9"/>
    <dbReference type="GeneID" id="28829121"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729624"/>
    <dbReference type="InParanoid" id="A0A194XQZ9"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000006">
        <property type="entry name" value="Heat shock factor binding 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9552" checksum="D92B5FEA740B61BF" modified="2016-10-05" version="1">MASNNEASSSPTNETDNRTSTNSLSAESSAPAELSAVVDELLNTLSNKFAGVSSEIFAKMDEMSRRLDNLETQLQSGGQNDGRSSPTKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRK4</accession>
    <name>A0A194XRK4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_680912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018214168.1"/>
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    <dbReference type="GeneID" id="28823894"/>
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    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DnaJ_domain_protein"/>
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        <property type="entry name" value="J_dom_sf"/>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
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    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268568" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="278"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="PROSITE" id="PS50076"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="399" mass="44442" checksum="DBC640C9CC74B2DD" modified="2016-10-05" version="1">MRLSFFTVGVLASLVIIVAAWSKEDQEIFRLRDEVEAHEGPGVTFYDFFGISPSASQDDIVKAYRKKSKLLHPDKVKQKFIADKSTGKDKKKSKKPGVHVSKGPTQAEIKAAAKAASDRFARLGIVNQILKGEGRARYDHFLSNGFPKWKGTGYYYARFRPGLGTVLVGLFIFVGGGGHYLALYMSWKRQKEFIGRYIKFARHAAWGENLNIPGLDAAVTPPPADETDPMAQPLNRRQRRMQEKDTKKDKGDKKSKLSKSAKASPAATPPVGATGPRKRVVAENGKILVVDSVGNVYLEQANEDGETQEFLLDPNELQQPTIKDTALYRVPIWAYNSIASRFLNKAEVTEEDDDDFDEEQNTPTSSSGAEDFEVLEKVKTTAQTENGKAIRRKKSNRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRY1</accession>
    <name>A0A194XRY1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_311031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
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        <property type="protein sequence ID" value="KUJ22809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018206632.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28816358"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_311031"/>
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    <dbReference type="OrthoDB" id="405996at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="IP5"/>
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        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="168"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="956"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ22809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1268" mass="140600" checksum="DCDB138B8DDC7021" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS13</accession>
    <name>A0A194XS13_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_575001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077194.1">
        <property type="nucleotide sequence ID" value="XM_018208776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS13"/>
    <dbReference type="FunCoup" id="A0A194XS13">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XS13"/>
    <dbReference type="GeneID" id="28818502"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575001"/>
    <dbReference type="InParanoid" id="A0A194XS13"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="69795" checksum="88CF5E6E759705F3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSB6</accession>
    <name>A0A194XSB6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_679990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077550.1">
        <property type="nucleotide sequence ID" value="XM_018213986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSB6"/>
    <dbReference type="GeneID" id="28823712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679990"/>
    <dbReference type="InParanoid" id="A0A194XSB6"/>
    <dbReference type="OrthoDB" id="3530845at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="17839" checksum="DFDB64395116456A" modified="2016-10-05" version="1">MSIASSTQSTTPIQSPQLPTIWQNIPFKIRKCQDGGEHRGNLEIVTWDSVSELGEPMGWGACLKEESEDLKQKFEVEMKGDFKNFYDYWPQGYRWTCCGLPGGYEWGCDSHFPGECKCDNCRYGYKLPKGFLEERNKSAHAKGLTLGEGNINGKEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTN0</accession>
    <name>A0A194XTN0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_744124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078030.1">
        <property type="nucleotide sequence ID" value="XM_018221023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTN0"/>
    <dbReference type="GeneID" id="28830749"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744124"/>
    <dbReference type="InParanoid" id="A0A194XTN0"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="62108" checksum="05ACFCE6C1212232" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUA7</accession>
    <name>A0A194XUA7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_633487</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078148.1">
        <property type="nucleotide sequence ID" value="XM_018211344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUA7"/>
    <dbReference type="FunCoup" id="A0A194XUA7">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUA7"/>
    <dbReference type="GeneID" id="28821070"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633487"/>
    <dbReference type="InParanoid" id="A0A194XUA7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
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        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="76"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1064"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ23793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1173" mass="130038" checksum="E4D5B2D18E15064E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVJ6</accession>
    <name>A0A194XVJ6_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_572236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="33000" checksum="7F0F70EFF8DE5348" modified="2016-10-05" version="1">MFAPEAARGNDNTLWSTMAGTIRVLSRTYAMSANPIQLYELEIRDTWFLFILSAKVIDAHHPAQDRLTRLILWARELGVLKRTLNSSQTPQQPIGQDDGTNVGFIVGSEDDVVVQHAATSAGRIWLDLPFLILDLQDAWKTVMNPSEPANHRCNLASAIARLAGVGLLDEALAGCGLSVLSLALETPESESTSKGLMLQLSQLLPMVQIWLHYAGDKLLQLSLASHPVDDTAWYTEGSAHGQLACDAEIDTASLNRERFQFWKTRLSELRKTDHEATSRVADSCFNIIEGVWKSVFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVL5</accession>
    <name>A0A194XVL5_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Acetylserotonin methytransferase-like protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_713087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28827751"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713087"/>
    <dbReference type="InParanoid" id="A0A194XVL5"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="283" mass="30525" checksum="FD905D88295E96BC" modified="2016-10-05" version="1">MSEKLVPLLGEDQKGTPPTYEAAAAQHGALPTRNGPPPSGAKPLPRGPFPLDIPVLNQLKGKRVILASASPRRKQLLATIGLVNLEILPSTKPENLSKADLGPFEYVLQTAVQKCLDVYTVALENSLASIPDPSLVISADTVIVTNSGHILEKPRSEKDHISMLKMLRDQKVHKCYTAVTALAPREDARAPGYNIETAVEETRVIFAAEVSDELIEAYVKTREGVDKAGGYGIQGMGNLLVERIEGSFDNVVGLPVRATLALIEKVVFNQGDDAGDEDEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVU9</accession>
    <name>A0A194XVU9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_726897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078197.1">
        <property type="nucleotide sequence ID" value="XM_018219100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVU9"/>
    <dbReference type="STRING" id="149040.A0A194XVU9"/>
    <dbReference type="GeneID" id="28828826"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726897"/>
    <dbReference type="InParanoid" id="A0A194XVU9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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        <source>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 120377</strain>
        </source>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF23317"/>
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        <source>
            <dbReference type="EMBL" id="KUJ24087.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078994.1">
        <property type="nucleotide sequence ID" value="XM_018219180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX34"/>
    <dbReference type="GeneID" id="28828906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727656"/>
    <dbReference type="InParanoid" id="A0A194XX34"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565639" description="Carbohydrate esterase family 16 protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32375" checksum="B8F07A2A4B115029" modified="2016-10-05" version="1">MKILTLALLLQCSYAGLIKRSGGISYIFGFGDSYTARCFNISGVQPSQFNPMGNPPDDRCTSSDGPNWIEYLTTTYNNSLILTYDFAVSGGAIPNSLVDQVMFQYEPMYSHSNHTWTGDNTIFMIWIGINDITILSSLYQNMSDFNVTLPPRFDQYFSLMENLYNTGARKFMFINMPPLDRTPMIQNYTTPIIQNFAQGVSLFNDVLLPQYVDWFQGNHSNIQTTIYDAHSAFNTILDDAPAYGFANNSCFNSTDCFWWNNYHPEGAVHQRLAKQMVTNLTPLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B210</accession>
    <name>A0A132B210_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_633035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060775.1">
        <property type="nucleotide sequence ID" value="XM_018211326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B210"/>
    <dbReference type="GeneID" id="28821052"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633035"/>
    <dbReference type="InParanoid" id="A0A132B210"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33748" checksum="D6EAFAFBA760868A" modified="2016-05-11" version="1">MSSTCKDVTAPNTMWNFCPSVGPAYLFAILFALTTITHLGQAIYYKKAYCWVIILSGLAQTLCYIFRVLSILNPEVFGDYAAWFILILIAPLFTNAFVYMVMGRMVWNYISSAKIYRITAWRFGTFFVILDVCALLVQIVGAASASGNNEANNKVLDGLHIYMVGVGIQQAFILLFFVFAIKFHRTYLAESRQQKKGNSPLVLLYVMYAALALITLRIIFRLCEYAQGLNSKIPNHEAFQYCLDSLPMLIALVLFNIVHPGRVMAGKESSIPGRKERKYKHVSNKAERESLGENMQVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3M4</accession>
    <name>A0A132B3M4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C2HC5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_661197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061360.1">
        <property type="nucleotide sequence ID" value="XM_018212591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3M4"/>
    <dbReference type="FunCoup" id="A0A132B3M4">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B3M4"/>
    <dbReference type="GeneID" id="28822317"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661197"/>
    <dbReference type="InParanoid" id="A0A132B3M4"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="219"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="513" mass="55786" checksum="4A4E4E81BDE58650" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3S9</accession>
    <name>A0A132B3S9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_743310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061336.1">
        <property type="nucleotide sequence ID" value="XM_018220938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3S9"/>
    <dbReference type="FunCoup" id="A0A132B3S9">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="28830664"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743310"/>
    <dbReference type="InParanoid" id="A0A132B3S9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="60052" checksum="6B50A7F498EC4088" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5B5</accession>
    <name>A0A132B5B5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_691891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216427.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mediator complex"/>
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    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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    </dbReference>
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        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med22"/>
    </dbReference>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
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    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12641" checksum="A2DCD8478039E99A" modified="2016-05-11" version="1">MEGAQQTTSGLIDRENATIAELLTRFLNLVKLAASPVEEGATKEVAAAQAFEMECESSALVRASEDLLQLTRELKELWLFGPLRGIKEGEGEGKMDEDSIKVGEMVEALLKKTSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5J2</accession>
    <name>A0A132B5J2_MOLSC</name>
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        <submittedName>
            <fullName evidence="14">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_691427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216319.1"/>
    </dbReference>
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        <property type="interactions" value="1006"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B5J2"/>
    <dbReference type="GeneID" id="28826045"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691427"/>
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    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="195"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="534" mass="61465" checksum="113AC1E98DF2A3D9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B777</accession>
    <name>A0A132B777_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_352169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062089.1">
        <property type="nucleotide sequence ID" value="XM_018206928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B777"/>
    <dbReference type="STRING" id="149040.A0A132B777"/>
    <dbReference type="GeneID" id="28816654"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_352169"/>
    <dbReference type="InParanoid" id="A0A132B777"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="37233" checksum="1F892BE778FD400D" modified="2016-05-11" version="1">MAFLRFLQRKLDGEIVFREPTSGEVPAYAILSHTWDEEEVTYQELKKGKDKSKTVNKAGWRKIQFCAEQAKEDGLEYFWVDTCYIDKKNAVELGTAINSMFRWYQNAARCYVYLSDVLKPNSRADDQRAWEEDFRKSRWFTRGWTLQELLAPRLVDFFGLERKRLGSKLSLESMIYEITGIANNALRGNPLLEFSIRERKCWAEHRNTSVEEDGVYCLIGIFDVSMVLNYGEGRGKAFKRLEEEIHKLNKGVDFEQFAVRRNLLLFPEAAQFVAREKELSKMHHRDHIGQRRFGFYRHKAVQYIRRHEEKYTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B798</accession>
    <name>A0A132B798_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_765093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062637.1">
        <property type="nucleotide sequence ID" value="XM_018221657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B798"/>
    <dbReference type="GeneID" id="28831383"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765093"/>
    <dbReference type="InParanoid" id="A0A132B798"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="39769" checksum="FEE85D027CC52AE6" modified="2016-05-11" version="1">MSGRLRPTALVPAIIAMAAFALTLVLVLAGRQPNQMSQYYLLSMNTSHLGDNIIQFNPTTAVATPAASKAEIQPRFDISHPIQSIGSGLDSIFSGIGNLTGLGNLTSNGGPITGITNAIEGIITNITNVVDGGLTTVENNLVQELMQSLGVKDCYNVYAGNVCSGNYTNTSDPNAAMTMDNCPTWGSIGAGLSNTSIPSSISIATVNVSVPILQGGGGGAGTIGSSLVLVMTLLSTFQIIGLVGSGILALGSLASVIMGRSRLIAYTVFAAAGLAFIGELVAAILITVIAGIVSGLINSVGSGVSLYVTSGKRALAFAWVSAALVILANIYWLAVWFVDFRRHSLKVRRRGTDQIGNWKGLGKELLSDLRSDPSLEEQLLKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B849</accession>
    <name>A0A132B849_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_764773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062943.1">
        <property type="nucleotide sequence ID" value="XM_018221648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B849"/>
    <dbReference type="GeneID" id="28831374"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764773"/>
    <dbReference type="InParanoid" id="A0A132B849"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40715" checksum="C54274AD7E6239DD" modified="2016-05-11" version="1" fragment="single">LSKIGRLFTLRRVVNLWLCNINSFAIPSILQSHPNPTSIPCLLHRPQLHCVNQSIFQMAKSKIAAAKKVVKKKPAVKKAAVKKAVVKKPAAKKPVARKRAVRGPSARSLKSKGWHAVKRDKSAVALLPQEAVRLPSSVVRKPFDNMKDYFDQIPAEILDKIMSYIEKDQVTLAVLSVTCKRFANEWSNRTESRKVDLRGRVIDIYGNAFTLHSLLGLWIPDMHYHWLANKFLTTETMLEDWRMYQIETEDAKERGREIKRRRREKKECARERARDKRLKKKNDQMNEDHPDWYDSSDSESESSIDFNNEDEPILMSEDSESEEDKEDEEDSDSFIYDDDARAGDWAARNGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B850</accession>
    <name>A0A132B850_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_599760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062930.1">
        <property type="nucleotide sequence ID" value="XM_018210115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B850"/>
    <dbReference type="STRING" id="149040.A0A132B850"/>
    <dbReference type="GeneID" id="28819841"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599760"/>
    <dbReference type="InParanoid" id="A0A132B850"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="34142" checksum="F12AAB0F8CE2F84B" modified="2016-05-11" version="1">MESLRTQSPLVKIEKRSQEPEASVALAAVASIPPSPEKPLLKPESPGLKRRQSQDPPTASTSVSHTIQPKRSRSDETIKILPAKYEFCPVEDMVVLIANMIQELIQTNDSLPLRSGVLTRFHSRTPPGISVLDYLNRLAKHATLTPPLLLSMVYYIDRLCLLYPAFTITTLTVHRFLITAATVAAKGLSDSFWNNATYARVGGIKIAELGLLELDFLYRVDWKIVPNPEALVEYYEGLVERSPGYEIEDTSSDEDDDDEDDSNDLGSSPEVKTEDIKSEPTTDTQWKAWMDDVSNVKAEGSHESKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8L7</accession>
    <name>A0A132B8L7_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_542427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="22930" checksum="2A23B224D6B7AE46" modified="2016-05-11" version="1" fragment="single">MFQLWTSLWRVPIERGNTSTQRSKSTAPSPSPEPSYTAVFAPPPAISSFPPPVPVGVSFQDEREYQYFCHFRDITVVELANGFEPTLWSPYVLRACDNPSIRQLVVATAALSIAVKTPPLRLWNPSNDHHHQYALQKYGQALKGIREMVGGGQDSTRIALISALLIFCFESLHGDLGRAVTHVQSAVEMIIKRLSNLPQPHYFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8S1</accession>
    <name>A0A132B8S1_MOLSC</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B8S1"/>
    <dbReference type="GeneID" id="28819815"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599335"/>
    <dbReference type="InParanoid" id="A0A132B8S1"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="663" mass="74059" checksum="0123C392A0717CFE" modified="2016-05-11" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Z7</accession>
    <name>A0A132B8Z7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_328300</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206766.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B8Z7"/>
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    <dbReference type="InParanoid" id="A0A132B8Z7"/>
    <dbReference type="OrthoDB" id="5296155at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08878.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39158" checksum="87A21DFC807E0621" modified="2016-05-11" version="1">MAFIFTMRSTGSSMHRRDPASGSSLPAISEDSASFLEPRSVPAIPDRAITRPSTRIWALGSPPVHTFEEPPPYNQFDGEGVLGPRGEKLSNVRRGVKENKWIAKRGGWKRLALIALIVIACIVGLAVGLAVGLKHHSSSKDTNSGNSSSPSGGASGTVGGPGNPASNTTFPAGSYRFDTFLDTVSTDCTNNSATWLCYPYSTYAQNAGASAATFEWIIYPDNNSPNYTISSTDNYFSIVFSNLTLSLMNSGASDEHYFFQTMMSKPTKPAVQLGSQNVASTCYFNQTTFQAYLYTKMPKSYPPSTTNTTDPSGAFIEWPYAVKVEQVAGAGPNVPTCVGPSGQVLGDFSVADETQLCDCLYLNTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B967</accession>
    <name>A0A132B967_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_558811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063301.1">
        <property type="nucleotide sequence ID" value="XM_018208426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B967"/>
    <dbReference type="GeneID" id="28818152"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_558811"/>
    <dbReference type="InParanoid" id="A0A132B967"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="386" mass="44346" checksum="1C196CBAA9E26D06" modified="2016-05-11" version="1" fragment="single">STRQSKRKATQEAAEKTKTAAKVQARKRAKKASLSFLPSSDEAENAPNRLGNLPREIFDEITSLLEPDALTCLSLTCKPILNVVGRKPWTECHTKRQVYYDRTSNFRRRLIPLLHRDAPHMIFCAWCNTLHPPLKPPREHRKTKLTKHCFGQWSTIDYLKGYSLLWEHIEEARENLVLESTDEIGFPMELLSGNYTVQHERLNYTLTSSGRQIGENLILKHQHIFRGIKAQSPLQMKNIMALPVRLCPHQTTSTDKPEPNRYTNGRLPSGLLTHSISREIPSSLRAGLPSPHLFRDATSSEKRQMDSAVPGTKALWTCRGCPTKWHVQYTGAGGRELKITAWHSFGDTEYHARQYWKMLVRREVANLGDEKRNSEFFSTTKQYLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA39</accession>
    <name>A0A132BA39_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_788167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063627.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA39"/>
    <dbReference type="GeneID" id="28832867"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788167"/>
    <dbReference type="InParanoid" id="A0A132BA39"/>
    <dbReference type="OrthoDB" id="10690342at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="612" mass="67815" checksum="071822464955C192" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAJ1</accession>
    <name>A0A132BAJ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_287906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063790.1">
        <property type="nucleotide sequence ID" value="XM_018206492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAJ1"/>
    <dbReference type="GeneID" id="28816218"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_287906"/>
    <dbReference type="InParanoid" id="A0A132BAJ1"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22980" checksum="3B58725A052C9915" modified="2016-05-11" version="1">MKLSPHQEYEKVATNDSEESLAESPKSTRGRSFLVSPRKKIISLIITFTLLILVVLVFTTQINRALSAPSSRHCGRSREEAISLGCSFDQLTATWLPASCSRKWEDEFLNTSGMGYYTETHATEPVDFSKLEFNTTYHSNRVHHVAHCLYMFLRLGDKDSPLDGMTLDPHHQKHCVSLILREMEYSPRANIVKDPGHIKPGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAJ6</accession>
    <name>A0A132BAJ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_287488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063787.1">
        <property type="nucleotide sequence ID" value="XM_018206490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAJ6"/>
    <dbReference type="GeneID" id="28816216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_287488"/>
    <dbReference type="InParanoid" id="A0A132BAJ6"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="284"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="152"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="7"/>
            <end position="20"/>
        </location>
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            <begin position="71"/>
            <end position="84"/>
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        </location>
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            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="51114" checksum="209FB0BEA6C1F926" modified="2016-05-11" version="1">MQHHPAHQQGPPAPHHLQQPRPSSIVHQHHQQVAPPPPQQQHSGPYASQHGLPQYAQSGPGPSGQHPQEIPYYTSHPSPYSTPSASGTYSSAAPETPDIMAAAQMTRPYPPIYHTPQSNSPASVASPSAHEQHRMYGAPTSQLQQNPQMYYAGPQQQYPPMPPQGAPSYAPQPHQQQQHHQSMTSQPNLLMSHNSGQHQMQQHPSQHPQQGMTGSPRTKMEPHVPQISRPAPPLGAPQQQHPQNGPPMNQNNVPGGNSGVNPNAAPGPIPATTPLVVRQDNNGVQWIAFEYSRDRVKMEYTIRCDVESVNVDTLSSEFKTENCVYPRACCSKDQYRGNRLVYETECNTVGWALAELNPCLRGKRGLIQRAVDSWRNSNQDPRLRSRRVRRMAKINNRKAVQAATHTPHMAGPSGPTGMPPSGNMGPGGAGNMGKPSLSGMGGPQLHHHHNHPDGSTQGGDEVGMFHQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAT1</accession>
    <name>A0A132BAT1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_724486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063877.1">
        <property type="nucleotide sequence ID" value="XM_018218904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAT1"/>
    <dbReference type="GeneID" id="28828630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724486"/>
    <dbReference type="InParanoid" id="A0A132BAT1"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="22022" checksum="E735F2723A5F1ED5" modified="2016-05-11" version="1">MHASFAVPKTAESEPELFLMLEIMDEIFTEAHSWCFDGPDCMLTWPRQLALSRFHTAAAPGQKLRAFDPKKEPNTLKTNFGYWKQFLTYCYQVAYRGSHFTTADDDQRTPESSIQLTGAQEKAWEAAFQSAVEQDRPALRDAISVLLMALICHEFGGNRYSSPLLSFCAMLSVKPYTKTWKEPGNYNSCLSGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAT8</accession>
    <name>A0A132BAT8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_724788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063132.1">
        <property type="nucleotide sequence ID" value="XM_018218930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAT8"/>
    <dbReference type="STRING" id="149040.A0A132BAT8"/>
    <dbReference type="GeneID" id="28828656"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724788"/>
    <dbReference type="InParanoid" id="A0A132BAT8"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36639" checksum="38264FFDC93FA908" modified="2016-05-11" version="1">MSAQIPGEESSQQAMQAQAPTPIPLRALTTLLNYERCISDPKFRGAKLLNSTFADPKLIDTRDPDRYVKLPGSKLASVKQVHFHVFRRESDGVSGTPSTNDIICPDALPEVHGLNFTKRELIYHESHEGDGCYEAVSLFQYFFEICPADQKLLIQIKTSSVLVDPFLREIAEHKMRGPKLQVIVSGMEEERISGHDNDRPHAVVVFPAPGGVGFVVDMTSMQFGEAGRGLFGEPYFMGTAEEFYIAMLEVYRTPRLQACAKRVWNRWENRENEGWCEYCGVGASEKVLQRCGGCKKRKVRYCRKEHQTADWKLHKYTCEKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBF3</accession>
    <name>A0A132BBF3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_787981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064063.1">
        <property type="nucleotide sequence ID" value="XM_018223124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBF3"/>
    <dbReference type="STRING" id="149040.A0A132BBF3"/>
    <dbReference type="GeneID" id="28832850"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787981"/>
    <dbReference type="InParanoid" id="A0A132BBF3"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="56952" checksum="0D30889DCD371C33" modified="2016-05-11" version="1">MVPFHYHPLDKNGGEVRLLTLLPGRFASDIRILITNVSFSVHNPPFFEVLSYTWGSQENPVDILVGPEEATLKVTRNLAEALPYLRLENQARTMWIDAICIDQSTLEERSSQVTRMGDIYTFAHRVVIWLGPERDGSTLAINMLKDIGSNIAVDWTSRTISPSGPKANLQWADKTIALPYKASDYIVLKALFQRAWFGRLWIWQEARHANSNSVLICGYASISWKAFGAAIFCLARKRRLSNIPGSLAELLKIIRVIYALLSIRTKEEAAISIKPDYTRTTGYVYINGQSLLSAYCLTICGTLLVNWASSPKAKDAPLTEDAGLTEASNFVKYLLETPDVLKDINCDPQKLPLEFLRGAFSMLTGRSFFTSEEGYIGLGPPGAEKGDVVCVLLGCASPMLLRRTSQGWYQVVGECFVLGLVGSEALLGPVPELYRLVYKYSYDHGCYIQHFFNKNTGETSWSDPRLNDLPLFEGPDQAPCSYVRCVENGYLLTSDAYTRMGAKIEDFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBV0</accession>
    <name>A0A132BBV0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064098.1">
        <property type="nucleotide sequence ID" value="XM_018220639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBV0"/>
    <dbReference type="GeneID" id="28830365"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740815"/>
    <dbReference type="InParanoid" id="A0A132BBV0"/>
    <dbReference type="OrthoDB" id="3061143at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="580" mass="64868" checksum="1B1B195D239AB7C4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBW9</accession>
    <name>A0A132BBW9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_320509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063502.1">
        <property type="nucleotide sequence ID" value="XM_018206709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBW9"/>
    <dbReference type="STRING" id="149040.A0A132BBW9"/>
    <dbReference type="GeneID" id="28816435"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_320509"/>
    <dbReference type="InParanoid" id="A0A132BBW9"/>
    <dbReference type="OrthoDB" id="3558197at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="25880" checksum="8FEB070B7C3D68DD" modified="2016-05-11" version="1">MIKFHPESMDFPLGKKRFIPEVDEEPLVDACAMDYIWPPLVTTEFEGPIVAQIVQQLNIGANSLDDQAIKILVDNFLTTESSNISLLDKATNIPHFQEILLPTICNRSESEELDNPEALGSLLGIAFTGQQHLDWVLLKELTTDAIAVALNTGNLNDAQSISLCIDTIKGTPAQLIEALSKSKSFCELFFLQEPDRKSDDRSREMFLALAATSHTHLHKCKIMLTGAGLVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC61</accession>
    <name>A0A132BC61_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_628589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063799.1">
        <property type="nucleotide sequence ID" value="XM_018211186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC61"/>
    <dbReference type="GeneID" id="28820912"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628589"/>
    <dbReference type="InParanoid" id="A0A132BC61"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="MIP31509P"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04110)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="278"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="958" mass="105998" checksum="5C5346A41E1ECF40" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC81</accession>
    <name>A0A132BC81_MOLSC</name>
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        <submittedName>
            <fullName evidence="10">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">LY89DRAFT_689858</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
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        <property type="protein sequence ID" value="KUJ09978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215985.1"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
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        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
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        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="99"/>
            <end position="118"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
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        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="798" mass="89916" checksum="5D4F23215441C626" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCM5</accession>
    <name>A0A132BCM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_267882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064358.1">
        <property type="nucleotide sequence ID" value="XM_018206333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCM5"/>
    <dbReference type="GeneID" id="28816059"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_267882"/>
    <dbReference type="InParanoid" id="A0A132BCM5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17507" checksum="F95B1735492C1C35" modified="2016-05-11" version="1">MIRRFSASRGFKAPCKLLLQSSASSSSKWSGLFKNYMRQKITSNRGINIAKNLWIVLFCSSFIVLPILHVIHTRPSEQEKELAAAQLSAVQSTRKDTLRRRFDEANLSPYERERLESELWAPLCKFLDMEVSRMVREQITTRSNIELARFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDB9</accession>
    <name>A0A132BDB9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_689860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064334.1">
        <property type="nucleotide sequence ID" value="XM_018215986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDB9"/>
    <dbReference type="GeneID" id="28825712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689860"/>
    <dbReference type="InParanoid" id="A0A132BDB9"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="246"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="5">
        <location>
            <begin position="523"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="924" mass="106498" checksum="2C361BC5819CBEC6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT29</accession>
    <name>A0A194WT29_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_594986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065471.1">
        <property type="nucleotide sequence ID" value="XM_018209835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT29"/>
    <dbReference type="STRING" id="149040.A0A194WT29"/>
    <dbReference type="GeneID" id="28819561"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594986"/>
    <dbReference type="InParanoid" id="A0A194WT29"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="84"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="34930" checksum="3E62D736F421FBED" modified="2016-10-05" version="1">MAAPSTEGYAPEWLEYEQALGQRPVLGGSAQDIVDQYTALGAMLATQAPPPDTSVETRDETADGVPVRIYTPPGAAGKKLPLAVYFHGGGYLVGDLNSEDPWCRVIAKSIPCIMVSVDYRLSTEHKLPVMLDDCLTAYRWARKNAADIGADQSHTISIGASAGGGLALTVADQLIKSGNKDHVQGIVAIVPVAAHPSSVPSKYASHYTAHKDNASGVPIIDWGSMETFYKTAAADPQDEKTFVTLSKNLKDFPPTYICTCGKDPLRDDGKVLEMMLKEEGVKTKSDFYEGVPHYWWMFPGMRNADKFFGNLIEGTKWVLGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU01</accession>
    <name>A0A194WU01_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_625504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065442.1">
        <property type="nucleotide sequence ID" value="XM_018211079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU01"/>
    <dbReference type="FunCoup" id="A0A194WU01">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WU01"/>
    <dbReference type="GeneID" id="28820805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_625504"/>
    <dbReference type="InParanoid" id="A0A194WU01"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36907" checksum="43626C3A68D7138C" modified="2016-10-05" version="1">MLRQIKPRNARSKRALDKKAPKAVENPKTTLFLRGTTCSQVVQDALTDLFQLRIPLAKKFTKKNPIHPFDDASSLEFFSEKNDASMLVFGSTSKKRPHAITLVRTFSYKVLDMVELYLNAETFRTLAQFKNKKCAVGLKPMLLFAGTPFESPVSDEYTLLKSFFTDFFKGEPADKVDVEGLQYIVSISARDTVDGEEVKPSVHLRVYLIRTKKSGQKLPRVEVEEMGPRMDFRVGRVKEADESIMKEALKRAKTSAERPKKNISTDIVGDKMGRIHLGRQDLKELQTRKMKGLKRSRDVARSEDEMEEDEISEDEPAKKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU55</accession>
    <name>A0A194WU55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_539390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065845.1">
        <property type="nucleotide sequence ID" value="XM_018208145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU55"/>
    <dbReference type="GeneID" id="28817871"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_539390"/>
    <dbReference type="InParanoid" id="A0A194WU55"/>
    <dbReference type="OrthoDB" id="3938221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12648" checksum="29DBB3CFE627C4FD" modified="2016-10-05" version="1" fragment="single">EDAYEDEDDEDDGEGLSLRRFESATAKPPRMIEDVEGADEDEEDEPRSPPLIPSEELEAIMEGADNEDLPELYGSVKKCPCHGKGHNAPDVVRAWDVPQTPEHHGRRIAVVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU84</accession>
    <name>A0A194WU84_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_226850</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_226850"/>
    <dbReference type="InParanoid" id="A0A194WU84"/>
    <dbReference type="OrthoDB" id="5413589at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="22679" checksum="6CF31BB0D6ACC233" modified="2016-10-05" version="1">MRHWRRMLCRQLHGILRCGNQGATCSSDSECAFNTCISGSCSGTLSSSSAAVSSTPVSTTSVPSSTATAVALGGTCTTSSQCANGASCYSVNSQEVLRCGNQGATCSSDSQCAFNTCVSGSCSGTLSSSSITSGSTSFGSVTTSFKSSSTAPAGGANVTVTSISTGVPAGFTTSVTVVNGVTSSVLVNSAGATTSFGAVATQTITSSTKGSGAGKLAVGFGGMFAVAAGVAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUU7</accession>
    <name>A0A194WUU7_MOLSC</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_723183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218795.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_723183"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="193" mass="20274" checksum="F661D96A9F75DB72" modified="2016-10-05" version="1">MHFTTTVPVALSGLFAASVVSGFSAPTRAMSLRFAGAIAVMAVPAIAVPVGIPEELVARNATTAEDKIKDKKKDDKKKDKKKDKASSTAAAAEATSTADVKRAVIEEELVARNETSAKDDKKSKKKDDKKKDKKKDKASSTAAAAEATSTAAAKRDVDDLETREPEPKKDKKKGDKKGKKTKSATAAAAVATS</sequence>
</entry>
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            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_233813</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066122.1">
        <property type="nucleotide sequence ID" value="XM_018206047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW04"/>
    <dbReference type="STRING" id="149040.A0A194WW04"/>
    <dbReference type="GeneID" id="28815773"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_233813"/>
    <dbReference type="InParanoid" id="A0A194WW04"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="649" mass="72833" checksum="0991BD6A37F1F301" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW16</accession>
    <name>A0A194WW16_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_594345</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066132.1">
        <property type="nucleotide sequence ID" value="XM_018209796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW16"/>
    <dbReference type="STRING" id="149040.A0A194WW16"/>
    <dbReference type="GeneID" id="28819522"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594345"/>
    <dbReference type="InParanoid" id="A0A194WW16"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="54381" checksum="7C00727638400864" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW52</accession>
    <name>A0A194WW52_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xenobiotic compound monooxygenase, DszA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_786322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066553.1">
        <property type="nucleotide sequence ID" value="XM_018222972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW52"/>
    <dbReference type="GeneID" id="28832698"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786322"/>
    <dbReference type="InParanoid" id="A0A194WW52"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="56283" checksum="46619F81DB7C032E" modified="2016-10-05" version="1">MTDRTTSAANGHNGSEHTNKKRKLNDKKQIILNAFAMNTPGHLAPGLWRHPRNKTDQYKKLSFCIELAQLLDKANFHAMFIADTLGPYDVYKGPANVVPALAAGAQFPVNDPLYLVPAMDAATKNLIFGVTASLTYEKPYSLARRLSTVDHLSEGRVAWNIVTSYLDSAARNHGLKEQIPHDERYAIAHEYMEVLYKLWEGSFRDDAVLADRETGVYIANDAVRQIHHKGKYFEVPGPAFCEPSPQRTPLLFQAGVSEAGNSFGGKHAEVIFVGGQVPEGVRPNVDNIRRVAKEEGRDPDHIKIVVGINVIVAATDDEAKAKREEYLKYADSEGALALFGGWTGVDLSGYADDDDFRFSDSPRVKSMVRRWSSTVPGTDNLPWTKRRIVEYLSVGGLGAKAVGSPQTVADELERWVEIADIDGFNLAHVVNPGTFEDIIEYLLPELERRGLHSRQVKKEGATAREVLFGTSRLPEDHPGSKYKWRAGEKEPKYQQAVSTVDGVSETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW67</accession>
    <name>A0A194WW67_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_786337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066570.1">
        <property type="nucleotide sequence ID" value="XM_018222975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW67"/>
    <dbReference type="GeneID" id="28832701"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786337"/>
    <dbReference type="InParanoid" id="A0A194WW67"/>
    <dbReference type="OrthoDB" id="3538694at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="24804" checksum="CD090E435DC217FC" modified="2016-10-05" version="1">MTGPTVAHPTLLLGDISAGCVLYLPPFDSRYPDCMCTCCYPSTSVDEGAYSHPVVVLWIDLQGRTGRQGDVHFLLCASTIRDDPRKHYTPIGVNLIVSESEDVNDDGRARYWLENGKSLRKPTKIQVDHIFVLPFTRFRVFDDAKSGFDYRLDGGSYQRLLKRIGSPIRNVVSTSRLGAIAMTAPVSKKEPEDEQLLSDTAKSSAGLSAFRVKSSGATVHALQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWC6</accession>
    <name>A0A194WWC6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_738058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066620.1">
        <property type="nucleotide sequence ID" value="XM_018220325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28830051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738058"/>
    <dbReference type="InParanoid" id="A0A194WWC6"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267530" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="151"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="367"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="565"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="711"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="823"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1456" mass="149712" checksum="95ADF82B9E2D21A3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXU9</accession>
    <name>A0A194WXU9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_737708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
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        <property type="entry name" value="KR_dom"/>
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    <dbReference type="InterPro" id="IPR016036">
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
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    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="11"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="930"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2312"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="930"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2398" mass="262019" checksum="F7D67315A4AE4E1A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY21</accession>
    <name>A0A194WY21_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_785843</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066852.1">
        <property type="nucleotide sequence ID" value="XM_018222929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY21"/>
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        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WY21"/>
    <dbReference type="GeneID" id="28832655"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785843"/>
    <dbReference type="InParanoid" id="A0A194WY21"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="23674" checksum="7A1D4F4865FBC1A2" modified="2016-10-05" version="1">MRRPDAPRPEIIGDDSGPTKPFPLRMGGQVVQGFGRGSKELGIPTANLPVDTAPWIASADSGVYFGWSSIQLPPDHPSLSPSGPEISSTTFPTTVPYPSAAVQVPPAKQKEGWRIYPMVMSIGFNPFYGNTVRSAEVHVMHGFGRDFYGCEMRVVVLGYIRPEYDYESLGKLVEDIGCDIEVTGRSLGRERWGNREAGVDGWLWGEEEEGRGESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYN9</accession>
    <name>A0A194WYN9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_200632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_200632"/>
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    </dbReference>
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        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19228" checksum="7B60DE81D4A7A1C8" modified="2016-10-05" version="1">MVSSRSDQMLRILPNQSTNRSGWMTFRGTRDLPRFEASRLPHFGQGRPISSDLCGIPRKKILPASGRTTFLILPSIAQVFVPFRIHQSTTPIEQKIFRERAKLALLPKLFSDYYYGPSPSRPTEMSSSSGTPSTLEQETILPPSGTQSSCKHIRPNADRSSLRAQQILLNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYZ1</accession>
    <name>A0A194WYZ1_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_709096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_709096"/>
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    <dbReference type="Proteomes" id="UP000070700">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="445"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="70"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="598" mass="65162" checksum="7EEAFAE9BF821B3F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZM5</accession>
    <name>A0A194WZM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_687528</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A194WZM5"/>
    <dbReference type="GeneID" id="28825244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687528"/>
    <dbReference type="InParanoid" id="A0A194WZM5"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="219"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="687" mass="79231" checksum="4C3C9525794E7647" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0G3</accession>
    <name>A0A194X0G3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_145582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068046.1">
        <property type="nucleotide sequence ID" value="XM_018205349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0G3"/>
    <dbReference type="GeneID" id="28815075"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_145582"/>
    <dbReference type="InParanoid" id="A0A194X0G3"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19169" checksum="5B7D04BEC3E84760" modified="2016-10-05" version="1">MTTSEEPSYILRHNKTATESERLDQQHHFISSFTPGFVSPAIPRAKLVNIADIATGTGIWLRELSSTLSHDQPNDRAAPSYTGFDISSSFFPTDLGPDFKFVQHDILQPFPKEYHGNYDLVHLRLLVGAVLEKQLPIALRNVIELLGHTWRLSPMGRVALHQNAFRSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0H4</accession>
    <name>A0A194X0H4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_754058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067722.1">
        <property type="nucleotide sequence ID" value="XM_018221305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0H4"/>
    <dbReference type="GeneID" id="28831031"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754058"/>
    <dbReference type="InParanoid" id="A0A194X0H4"/>
    <dbReference type="OrthoDB" id="3544365at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="102"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="386" mass="44543" checksum="266F201276919094" modified="2016-10-05" version="1">MIVSSGPASEKEIVEAQPVPVRTELDKALWRNCELTDHYYDLVAKEDSVQWMTYDELEGVQSNAMIKWIQDPAKNPLFHKMGARSLGLKRSNGQLSEVARTAKRPETRRKVMEWEENACEHLAPLYKEMVLLRTEIAKLGRHKSFFEYKSHFKMMDARSVATSLEDLRKDLTPQFQSHMKSISEMTLKDRNFSASTTQLRQDVQQSGNDIQAFPASHEECQLHWGEVYKYSFEKRKKFPWREEVHDFPDYFPLNTTLPGLLSIFGHVFGIKFREILPDQAEYTRYVADYVAHPDSFSKAMNREDTLKVFVAHDTSESWKGLTTLGVVVFDSLKRSNKPIGGLCLPFTTYKLDRNQMVKKRGPGIAIQTAFERASTDRPTLLYPSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0J7</accession>
    <name>A0A194X0J7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_591766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067747.1">
        <property type="nucleotide sequence ID" value="XM_018209666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0J7"/>
    <dbReference type="GeneID" id="28819392"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591766"/>
    <dbReference type="InParanoid" id="A0A194X0J7"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="23998" checksum="4CFDE4C5CF29AAA8" modified="2016-10-05" version="1">MSSNPPSQFSQPVADPVAHFKSIPWCSSLLSSKSVVQVLVPDRTPLASTESAMVRETFNTPNTVNACVTFFRYIPPEGGKKGMEERGEDMKNPFLQICALLDLGSGINGYAKTAHGGFFGVVLDEVMGTAANLQAAQGAFTVSLKVDFKKPLYTPSVVLARGQVVKKQGKRLSLKGSFEDKDGNILAVAEGTWIMVDRDIGRWTTEEQKEQAKKRAEGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0M5</accession>
    <name>A0A194X0M5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067864.1">
        <property type="nucleotide sequence ID" value="XM_018215528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0M5"/>
    <dbReference type="GeneID" id="28825254"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687579"/>
    <dbReference type="InParanoid" id="A0A194X0M5"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="261" mass="30530" checksum="1A93F8C430720372" modified="2016-10-05" version="1">MIWAFASPEPAFVAQVKSRKVGRRYHQLREIPAVLHTCRESRNEFLETDDPNDISLQRRRLAHPVYKLHFREGSTRNGLRGRFMSSDTDTFWPLEIDTIGHAFANHFVNPSLSPVLRHLTITRCSLDEWELKSLIDKVPTLGTLTFALSASYYSRFGSLLPEINGELNINGFPTVWQNHLQSYRSKFNTLLKKMAPKYPKLNTLKVKWRFQDQIIANEGIKLLPPPEEDPFKELDREMNRISRRKIKEKRERKQAKDRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X120</accession>
    <name>A0A194X120_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fructosyl amino acid oxidasesarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_736888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068245.1">
        <property type="nucleotide sequence ID" value="XM_018220185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X120"/>
    <dbReference type="STRING" id="149040.A0A194X120"/>
    <dbReference type="GeneID" id="28829911"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736888"/>
    <dbReference type="InParanoid" id="A0A194X120"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="48939" checksum="A68E2ACFF54365EF" modified="2016-10-05" version="1">MADSKFPSSIIIIGAGIFGLSTALAISRRHPSTKITIIDRLTPPIEDGSSVDTTRCIRADYADPIYAQLALEAQQKIEADPDLSRYYFKQGMTFVCDGKPSRFTDIWHAQVKLARGRHHQDQIISLSSSQEVFERIHGSGSELPTKTKLGRELRWNKAYCNLDDAFIDARECVRIYYERCLAQPSITFQCGVAVDHLNLIDGICHGVILEDGSVHKAEKLLVAAGAWSSKLVFLEGRMYSSAIEVAWFKVTPEEEEKWKHMSITTNLSTGLNVFPPYKGEIKVLRRSAGYCNTVTIENPEDRKNKIEVSLPRTSITHPGMHMPEEAEKLMRQDLQEIMPSLAQRAFDRTKLCWLAQAPTADFLIAPHPRISGLHVATAGSAHAWKFLPVIGDLVLDSMEGHLSPALTEKWAWSLEGRDGGNAPRMDGKPVELREIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X145</accession>
    <name>A0A194X145_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">laccase</fullName>
            <ecNumber evidence="6">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_590475</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068271.1">
        <property type="nucleotide sequence ID" value="XM_018209596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X145"/>
    <dbReference type="SMR" id="A0A194X145"/>
    <dbReference type="GeneID" id="28819322"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590475"/>
    <dbReference type="InParanoid" id="A0A194X145"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267757" description="laccase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="79"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="207"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="446"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ13916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="592" mass="64161" checksum="2275561594731AAC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X174</accession>
    <name>A0A194X174_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_736945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068301.1">
        <property type="nucleotide sequence ID" value="XM_018220194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X174"/>
    <dbReference type="GeneID" id="28829920"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736945"/>
    <dbReference type="InParanoid" id="A0A194X174"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="67" mass="7311" checksum="3887DA01C7406677" modified="2016-10-05" version="1">MIFTEDDAAECLANFPANLGINTTMEQIVDDLVQVARSLNPILTRLTTDAENESNPAAEGRRIGHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1N7</accession>
    <name>A0A194X1N7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_590926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068466.1">
        <property type="nucleotide sequence ID" value="XM_018209624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1N7"/>
    <dbReference type="GeneID" id="28819350"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590926"/>
    <dbReference type="InParanoid" id="A0A194X1N7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26635" checksum="842DFD3B8DB75407" modified="2016-10-05" version="1">MTTPTQYTFTSSRSLRALSFSIHVTGLMFFAASFWWLPNITNPLHNGFGGSYQFLTIIALTISTITFGVGFLANLSLFADLSLGQQLFAVKNWLSICATPLEVLVTILYWTLRTIDKKLVVPPDHEVPFIPDFGFHAIPALMLTLDLMALSPPWSMKILNVVLLDLVLTFSYWSWIEYCFSVNGWYPYPLLGSLSVSQKLLLSIVSAALMTGSTMVLESVHERVDQLIWRNTDIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X244</accession>
    <name>A0A194X244_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_720618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068621.1">
        <property type="nucleotide sequence ID" value="XM_018218585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X244"/>
    <dbReference type="GeneID" id="28828311"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720618"/>
    <dbReference type="InParanoid" id="A0A194X244"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.400.10:FF:000001">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="713" mass="78988" checksum="A80006638030522C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X263</accession>
    <name>A0A194X263_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068646.1">
        <property type="nucleotide sequence ID" value="XM_018213229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X263"/>
    <dbReference type="GeneID" id="28822955"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671655"/>
    <dbReference type="InParanoid" id="A0A194X263"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="32440" checksum="A6B189ECE114161F" modified="2016-10-05" version="1">MPVADVEMVGPEEALILERHLGVQKPFSWERAAAKEATSRAAVEESMGISSKGAVITYSTATEEAMVWEKSTTTEKSAFARDKPIPSKKSNISAQPTSLRDKQILWEKEHVVNKPAPYQSKPLAWEKSNSPNKPTPYKSKPVTGENPNSSNKPAPYHSKHLAWEKPKSSKKPSFAQERALTPKKAPTPNMSPIRRQVNTQMNRSPLKKGLDIGKQKVSNDEEMQGMDIDSKPEKDHQSSLKKSRWRRHRKYLRSLLRAFFHRLPFPIEYDHGTEVFTWILFGLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3E8</accession>
    <name>A0A194X3E8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_708398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069046.1">
        <property type="nucleotide sequence ID" value="XM_018217677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3E8"/>
    <dbReference type="FunCoup" id="A0A194X3E8">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="GeneID" id="28827403"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708398"/>
    <dbReference type="InParanoid" id="A0A194X3E8"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF101">
        <property type="entry name" value="HIGH-AFFINITY NICOTINIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="494" mass="54960" checksum="B846D1A066317BC1" modified="2016-10-05" version="1">MSSNIDMEKRDLESPVDGDLASKHEVNLKVDIENGRLAIDHVAEKKLMRKIDLNLITLFGALYLMSFLDRSNIGNANLTGFSTDLRLVNNQYGAAVSIVYATYVVFEPIWTVLLKILTPKFLMTASTLGWAALTIGTAFTKNFDQLAAVRVLLGAVEAAIIPCILMYITMTYNRDEYAIRNTYVFSASAVSGAFGGLLAYGLTQIESGGLHGWQWMYIVEGIISFCLCPITFFWLPNSVAEAIWLNKEEKELITVRLERNKGAYDSEEKFSWSEILRCFKDWKFYVQSISHFGIDTTLYAVTTFMPKIIAGLGFTTTVNAQLLTVPVYFVAAVSYLILGYLSDKYKNRSTFLLIALSSCLIGYIILIASPSTGVRYFGVFMVAIGLYATTSLNIVWAATNHAGYFKRAFATGTVQLVGNSAGAAIGFIFKTQSAPRYFEGLYFALGVTIMSITLTSIMSILLRRENRKKLRLIAEGAADQPELGDRNPHFLYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3M8</accession>
    <name>A0A194X3M8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_620889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068782.1">
        <property type="nucleotide sequence ID" value="XM_018210928.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X3M8">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3M8"/>
    <dbReference type="GeneID" id="28820654"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620889"/>
    <dbReference type="InParanoid" id="A0A194X3M8"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000009">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="291"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="520"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1970"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1970"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1995" mass="224108" checksum="5E9FC5A50526EA75" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X428</accession>
    <name>A0A194X428_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_735997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069295.1">
        <property type="nucleotide sequence ID" value="XM_018220072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X428"/>
    <dbReference type="GeneID" id="28829798"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735997"/>
    <dbReference type="InParanoid" id="A0A194X428"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="335" mass="38443" checksum="E09DAE13D009D4B7" modified="2016-10-05" version="1">MEGANRPAAMVSKCAVDCYHYSSGCGPRSPFYFNGGGIKPDDLLRRLMELPQHIRDQIYELVVRHPYNAPTWWLGADGNLRAPCPDAYTLPKPDHLSIPTLENKDGPWLKWSSSSFCIVQTFVEQLHMLSAEGSQSASDCVEDFGEFFGERTIIEMNRFRDWICKSRLRRTVRKDPCLQLRNLEPLFKHIKHLCLEVKVPNQSVNKPDSVSYKIVTGAEDFTLRCEKIHNNIPTLKSLVVFCQLTTQNLKKALILPEQQSWIQGCKLIAAEKVNVRLYILDRSTEDDEPMSRILSPGYTDRSGEIENLWKDEERSLENILSPTRNMPRTGDLWMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5I9</accession>
    <name>A0A194X5I9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_750798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069803.1">
        <property type="nucleotide sequence ID" value="XM_018221214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5I9"/>
    <dbReference type="GeneID" id="28830940"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_750798"/>
    <dbReference type="InParanoid" id="A0A194X5I9"/>
    <dbReference type="OrthoDB" id="508139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="692" mass="79368" checksum="CEB4B497EF7254B8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6D3</accession>
    <name>A0A194X6D3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069727.1">
        <property type="nucleotide sequence ID" value="XM_018215215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6D3"/>
    <dbReference type="GeneID" id="28824941"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686133"/>
    <dbReference type="InParanoid" id="A0A194X6D3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16197" checksum="42AE15009846000A" modified="2016-10-05" version="1">MRLQQHASLALSHHARYFLSLLLCPESSVLALDRHLSFKSKQHATLIPLRALLLQAVTKSSSQVKSPSPACLPACLPACLPAYLPTCLSPGGPLSLVGKVALCSSAQQRVIVTRMAGSFHENHRLAGLGGHAEPASRGSIRRDFMHDESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X787</accession>
    <name>A0A194X787_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_697996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070390.1">
        <property type="nucleotide sequence ID" value="XM_018216946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X787"/>
    <dbReference type="GeneID" id="28826672"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697996"/>
    <dbReference type="InParanoid" id="A0A194X787"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="429" mass="47671" checksum="AD0CC071C19AFA17" modified="2016-10-05" version="1">MAGSVFARKEKIASRPKVKTGCTTCRVRKVKCDEKKPFCQKCINTGRTCDGYQSPFKYFISQRIIRAPNDGIKSNDVLPPIRPTFLGIAPQDIDLLSRYFSTKTLFEVKLGYNEEARQVLLASLTDSPLRHAVLSLKALREDLETSGDGPESVVQQTSSFQYGLQQYNIALRSLAFNLSSPSSSGLKSALLCCQVFISIEQVQKNHGAMAQHIIRGLRIMHEYRARPTFVTPNKLVPAYHRQLPSLDIFIIKLFAAPCKFAEPPATATVNGTTLSAGLISLLQQPLGSHGLRTIAPDMRTKLTSIATLTIEFLSKVSQVDTTDTALRLLLEKATLLKSLESWLNDLEIVLTTIEYPASEPLSVAFLRLFHLVLKIVLLGALESSPDLYDRLRPENDRFQNIANNVGERVKAYIRCIGTSSGRGERSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Q7</accession>
    <name>A0A194X7Q7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_707954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070197.1">
        <property type="nucleotide sequence ID" value="XM_018217648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Q7"/>
    <dbReference type="FunCoup" id="A0A194X7Q7">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="GeneID" id="28827374"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707954"/>
    <dbReference type="InParanoid" id="A0A194X7Q7"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267988" description="ribonuclease T2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27704" checksum="52CCC11E201A0FB2" modified="2016-10-05" version="1">MSSLTKTTIFSLLLRLSLAGTPESCPANAADLSCSGSSTNTCCINSPGGLFQQVQFWDTDPATGPSDSWTIHGLWPNNCDGTYSESCDSSRAYTDITTLLKNAGETSTLSYMQTYWLSDDESDEKFWEHEWSTHGTCISTLEPSCYTDYTTGEEAVDFFVKVVELFQGLPTYTWLANAGITPSDDTTYALSAMESALESAFGAPVILLCQDTNVVYEIYYGYNTDGNLQNGTFIPTSNVGTSTNCPKTVKYPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X859</accession>
    <name>A0A194X859_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_80545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070703.1">
        <property type="nucleotide sequence ID" value="XM_018223424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X859"/>
    <dbReference type="FunCoup" id="A0A194X859">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X859"/>
    <dbReference type="GeneID" id="28833150"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_80545"/>
    <dbReference type="InParanoid" id="A0A194X859"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000040">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ16348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="36171" checksum="61FF92FEF2E8A96D" modified="2016-10-05" version="1">MPGLPSSVDLDECIESLYKKNLLAESIIEAICAKTKELLMQESNVVHVQAPVTVVGDIHGQFYDLIEIFKIGGFCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPHRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVINDQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVKKFLEVNKMSHILRAHQLCQEGYQVLYDDRLSTVWSAPNYCYRCGNMASVLEVSDTGERFFNVFAAAPENDLHKDNPGGQDKIADGSALPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X885</accession>
    <name>A0A194X885_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_707660</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 22">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070735.1">
        <property type="nucleotide sequence ID" value="XM_018217626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X885"/>
    <dbReference type="FunCoup" id="A0A194X885">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X885"/>
    <dbReference type="GeneID" id="28827352"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707660"/>
    <dbReference type="InParanoid" id="A0A194X885"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="19">
        <location>
            <begin position="835"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1030" mass="116184" checksum="4FC552FDFB410309" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8N0</accession>
    <name>A0A194X8N0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_697423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070497.1">
        <property type="nucleotide sequence ID" value="XM_018216900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8N0"/>
    <dbReference type="FunCoup" id="A0A194X8N0">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8N0"/>
    <dbReference type="GeneID" id="28826626"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697423"/>
    <dbReference type="InParanoid" id="A0A194X8N0"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120284">
        <property type="term" value="F:tryptophan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="14">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="30274" checksum="C3D3BAD5066195F3" modified="2016-10-05" version="1">MDAVIDLSDRSKALDLNHIRVQLIRMEDSIIFHLIERVQFPFNGTIYKAGAIDIPDSSLSFLDWLLCKREELDSMIRRFQSPDEYPFFPESIKKPILKPLHYPKILHKNDVNVNEKIKNSYIENFLPGACANFGRQDRGETEENYGSSATADINCLQAISRRIHFGKFVAESKFQTETERFTKLIKEEDREGIDVAITNAKVEQQVLDRLRLKATTYGMDPAIGAEGPGKINVDAVVTMYRDFVIPLTKEVEVEYLMQRLGPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X923</accession>
    <name>A0A194X923_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_684770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071025.1">
        <property type="nucleotide sequence ID" value="XM_018214947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X923"/>
    <dbReference type="GeneID" id="28824673"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684770"/>
    <dbReference type="InParanoid" id="A0A194X923"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KUJ16670.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="58150" checksum="4956B861CB608439" modified="2016-10-05" version="1"> </sequence>
</entry>
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    <accession>A0A194X9H5</accession>
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    </gene>
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42530" checksum="4F7218D333346956" modified="2016-10-05" version="1">MLVCYFGKTIPVRLVLAAPIFTLIGGGSRVFCPIILATLADTSPYSKRTQLFYFVALSEDLANIVAPPIASMTLARNVWLPFFSSTVIFIPIIILIWTLRTLKNKTVTVLNTPLDTDDADAEVSRPLLPLLEDHEDAWQRIRRNIWGEVFCMFWDRDVSILLLCIFGLRFAFESEGFFAQYASERFCLRYDQTSWFSWAQSLAALLSIGFGLPMLTYYCRRRYYLQRFIDFYIIVLCLIILSCGFFSVWRVTSSIGFGIATFLCGLGEGAEAGIQGLASSYVTFAQHSRLFTTMNNVEMVARVIGGPVTAHIFHKGRKPDGTPTGIAFLISSINQLVFFTTLLALVWIRLVDEGDERGRREEIEEGDSERREEADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9X6</accession>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215187.1"/>
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    <dbReference type="GeneID" id="28824913"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_68601"/>
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    <dbReference type="OrthoDB" id="5305647at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="260" mass="29529" checksum="231EEF47B0B43F48" modified="2016-10-05" version="1">MEHNTFDPFDFLEQNPIDPVNFIDSYTTPLTFDQTTNHFENYRVSDDLLYTNDFSLWGNQMDRNLGMSLQRDCSPCEPYSSSNFMTYDDFTSDSMSLIDMERLISTSPGLQSSPAISQQQPSVSSASLSDSSPSRSDQTAISPEESPRQSLGASSSDVEWTCRHCARSFTKKYLRTKHEQVHTKPILCPLAPRCQHRTAMKRDMRRHVAVHHAGDNAVSSPVSAQSFTCDVSGCRYEHTGFKRKDHLTRHIRKVHARLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBN0</accession>
    <name>A0A194XBN0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071924.1">
        <property type="nucleotide sequence ID" value="XM_018213058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBN0"/>
    <dbReference type="STRING" id="149040.A0A194XBN0"/>
    <dbReference type="GeneID" id="28822784"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668883"/>
    <dbReference type="InParanoid" id="A0A194XBN0"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
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        <property type="entry name" value="CBD_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
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            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ17569.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="55020" checksum="582129DF4FEFB10F" modified="2016-10-05" version="1"> </sequence>
</entry>
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    <accession>A0A194XD82</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KUJ18135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="587" mass="66130" checksum="12353CB22E2313A6" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="60" mass="7058" checksum="58B1B8553132466F" modified="2016-10-05" version="1">MAPSRSAAATSPYAKDEKVLCFHHDMLYEAKILDVRPTEDKENPSWQYKIHYKGWKNTYP</sequence>
</entry>
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    <name>A0A194XDZ2_MOLSC</name>
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        <recommendedName>
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        </recommendedName>
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="26"/>
        </location>
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            <end position="237"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27485" checksum="CCC176C598269D4D" modified="2016-10-05" version="1">MAPARRRPRRRVRAVPTAASARPSRRAAVEATAKNELILARPKSVPKPTLVYEADREDKDSFFDNEVPAEIYKMIMDLLDPGSATCFGLVNRKAHNAWLKNYDYGDVNLNTMAIPAPGGLTRPLRTLLWFWAGPDLFFNALLGIFTPEEELMETYEDFMDLHKDEVAQQEREAEEREEEEEREREQRRYDRQQRRLHTGTVAHAHEVEGYSDNKHYNSDLEEENSGDEDDEDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF97</accession>
    <name>A0A194XF97_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073198.1">
        <property type="nucleotide sequence ID" value="XM_018222424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF97"/>
    <dbReference type="GeneID" id="28832150"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780838"/>
    <dbReference type="InParanoid" id="A0A194XF97"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12869" checksum="8417C38B3E93927D" modified="2016-10-05" version="1">MVTKVRNSGKLKLVFHLKEHVVSDEGIDIVIIPAAWTLLTIEQQKQSCSWLKPLVAATQNDTRVLFFSYELDVNGTSLWNQLLDQSSSLLEVLHDLRRDAQGYSGSIEHYIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFU3</accession>
    <name>A0A194XFU3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0103-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_581841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ19011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073366.1">
        <property type="nucleotide sequence ID" value="XM_018209129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFU3"/>
    <dbReference type="FunCoup" id="A0A194XFU3">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFU3"/>
    <dbReference type="GeneID" id="28818855"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581841"/>
    <dbReference type="InParanoid" id="A0A194XFU3"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="326" mass="35974" checksum="259A32C0B3E72132" modified="2016-10-05" version="1">MSTRVASHAGSWYTSNPKKLQSELDAWLQGVSIDGADLPVAGARVIIAPHAGYSYSGETAAWAYKTLDLSKCKRIFLLGPSHAYYLSGCALSRHAKYATPLGDFVIDKEIVAELKETGKFDTMSTQNDETEHSLEMHLPYIYRMISKTFDDPTKYPTLVPILVGNTDPSKEQQFGKLLSKYLADPTNVFVVSSDFCHWGTRFQYTYYLPQSAIQAKSSKGQSLHRREAAPTDPPIYESINELDKQAMDAIESGKHSAFLHNLEQTGNTVCGRHPIGVVMAAIEVLEKEGKASGTSGKFKFVRYARSSEVEDITDSSVSYASAYAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFY8</accession>
    <name>A0A194XFY8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protocatechuate 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_705975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073411.1">
        <property type="nucleotide sequence ID" value="XM_018217489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFY8"/>
    <dbReference type="GeneID" id="28827215"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705975"/>
    <dbReference type="InParanoid" id="A0A194XFY8"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268191" evidence="1">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="104"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="34325" checksum="92B18A35A27A47A6" modified="2016-10-05" version="1">MYFSSLLISALLAPLSVVAHPGHHEALSYKEITRRAGLSKRCEGAAASMNAKRWLRHQERRSLAARANTTVVITTEAPYYDVIQNDTCVLTPEVTTGPYIWPQSQTLRQDMAEDQPGVPLYLDIGVLDTNTCEPLEGVLVDLWHCNATGSYSSFEALDPNTPFAELLESLNKTIGPDLDLHTGNSTFLRGMWPTDANGMMEMKTIFPGFYVQRAIHIHAQVHTNWVVGINGTIVSDETISTGQIFFAEDLSEQIMALEPYASHTQINRTTNAVDSIYSSEDTAGFDPVMAIVPLDGEDVTKGMVGYLTLGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFZ5</accession>
    <name>A0A194XFZ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073404.1">
        <property type="nucleotide sequence ID" value="XM_018214616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFZ5"/>
    <dbReference type="GeneID" id="28824342"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683011"/>
    <dbReference type="InParanoid" id="A0A194XFZ5"/>
    <dbReference type="OrthoDB" id="3202396at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34527" checksum="8F90D99EF0BD3D92" modified="2016-10-05" version="1">MDIKPILPPTASKVSDIRIFSPEFNKTALRNNMSMGTILLIGASFQAILALLPIPRIYSGLPAVFMLVLKITDTVLITYNIKANPYLKNMLPKKTTAQPLDLNGNFSGAGKQKIAVLLLGAKSNHPLGFFAPDFGKVGGYLKKMSDLLEDDHTQESGFLGQSCLNKTDKNGANEFVFISYWRSLEDVHRFAHGSLHREAWTWWESTLKRHNYIGFMHEVYEAPAGSYEGVYINFQPSLLGATTYLKKDGKMVAGEVRPEYINPLVDANKGPMRTSNNRRGLKDRKDIADEMFNENNAYETVGTLGGTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGG6</accession>
    <name>A0A194XGG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_696295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073222.1">
        <property type="nucleotide sequence ID" value="XM_018216820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGG6"/>
    <dbReference type="GeneID" id="28826546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696295"/>
    <dbReference type="InParanoid" id="A0A194XGG6"/>
    <dbReference type="OrthoDB" id="2532623at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="86" mass="9549" checksum="DFE5720AAC0161C3" modified="2016-10-05" version="1">MPVSKKMKVQREHRKAEAAGTRAPVKANGLPVKAPKPTSLCANCKKEIVNTNLKQLEVHAETHDQKVWTKEKCWPDIFKGETAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGI4</accession>
    <name>A0A194XGI4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_612885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073633.1">
        <property type="nucleotide sequence ID" value="XM_018210641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGI4"/>
    <dbReference type="GeneID" id="28820367"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612885"/>
    <dbReference type="InParanoid" id="A0A194XGI4"/>
    <dbReference type="OrthoDB" id="3555193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="37338" checksum="47248795B5C8CBA1" modified="2016-10-05" version="1">MPTNPMPRSLTSRVLSTISLRPLGSKSSSNMALSTHQIEVYEDCISKLRTEIFKLEDQQTKLLSALIIISRCIKSDLAPSRNYKPFPFADEEDEKELLCSIDDHIEYLAAELQQIQNRVWKTSFQPSRSGRPGKVPESERRILPPTSIIEDFSKPQLQLVIDLGQLIVKKAELMVWSDLLEGNLVFWSNVWKEVQKGRKLKDCRCDRLRPPFSEGHKIKDDIPISPRSSVRPSLTRSNAVRCTKNGRIRRKEVPVQELIDRFLKKVGDGDGEESKRDDERHDSAISMDIDGHKSNGHNSVNDLAIVKQDSGVDVGEGDGKGEGRLRRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGN4</accession>
    <name>A0A194XGN4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_731760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073715.1">
        <property type="nucleotide sequence ID" value="XM_018219611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGN4"/>
    <dbReference type="GeneID" id="28829337"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731760"/>
    <dbReference type="InParanoid" id="A0A194XGN4"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="470" mass="53285" checksum="4C0540E82CBCA805" modified="2016-10-05" version="1">MSGLEKEQDYRLSDSIMASEEQKALGLVWVGQEIIADTDSVSAIKAAPSGSTLQDTAIAPKLCKTVEVKTRCGQLLQMTIEPDQMVVFMPDMFCTIMAVEPIVNSSYASVKLEAEEWLFRELNADETLRKRIRKTSWWWFAAAAAPHASKEDLKVLVDWGNWVFPWDDPFDNGSFRGDPTGAKKMLDNLMSIMRGEPQSPKNALVIAHNDIWRRIVESASEGKFPCLNVTSHPKRDAEKAVVQKRYAASMELYCSGALEGVGNYAKSRIPGLEEYIDMRRRSVAVLPIVCMIEFAMKIEVPDIAYNDKSLVTLRRILDDVVFLQNDMMGYAKEERECVTHNVISILRNLGMTTQEAFDKGGLMLRERELYLLEAFFVLCRLLSPYSTDATHSLEHGYRDWHIVQADLPSWGEAVDREVQKYIAVVHSCMVANLNWHHQSHRYFATYKDMAREFGAVVVLEHPPTMSEGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH99</accession>
    <name>A0A194XH99_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_683081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073502.1">
        <property type="nucleotide sequence ID" value="XM_018214632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH99"/>
    <dbReference type="FunCoup" id="A0A194XH99">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XH99"/>
    <dbReference type="GeneID" id="28824358"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683081"/>
    <dbReference type="InParanoid" id="A0A194XH99"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="780" mass="85498" checksum="B80239C772D83A20" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHC5</accession>
    <name>A0A194XHC5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073884.1">
        <property type="nucleotide sequence ID" value="XM_018214688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHC5"/>
    <dbReference type="STRING" id="149040.A0A194XHC5"/>
    <dbReference type="GeneID" id="28824414"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683349"/>
    <dbReference type="InParanoid" id="A0A194XHC5"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF38">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="198" mass="21533" checksum="3E84B5EAE9F0BBAD" modified="2016-10-05" version="1">MITNKLAIASPSLGLHPSHTLPNKILAVAQNGIQGVEVTYPDLEAYATTSSISMLDAASRIKNLCAENGITILSFASFQNFEGHASPLKERLAEASNWLAIIKALGAEYLQVPSSYDVNINRDHHVIISELRQLATLAAAEKPVIKIAYENLAWSTHCSLWQEALHIVNEVGMESFGLCLDSFHIAVALWGDPYHPSG</sequence>
</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19659.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="681" mass="74021" checksum="A861A2A3306122F6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_642482"/>
    <dbReference type="InParanoid" id="A0A194XI42"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19432.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57216" checksum="6F0F245916003648" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIF9</accession>
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        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIF9"/>
    <dbReference type="FunCoup" id="A0A194XIF9">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIF9"/>
    <dbReference type="GeneID" id="28826495"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695536"/>
    <dbReference type="InParanoid" id="A0A194XIF9"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="305" mass="33509" checksum="478E7D881DB23D43" modified="2016-10-05" version="1">MAPDYQTWTVTDPWLPISCSLGEGPYYEAATNTLRFVDIIKKRLHTVSLTTGPSSLKTLQLDMPVGVTADIEGVDPAKKILVGGKNGIFVLDRESGTYELLKRFYESEEKDDRLRSNDGAVDPQGRFWVGTMNDFHVGEPQAEGALFRFNRDLTRHPIRPSLTIPNSIGWSPSQTTAYFVHSTEKTIFAFDYSSSTGALTNERVWYKHQGTGDPDGFKVDEQGNLWQAIYGEGKVLKIVDVEGKGVVRGEVRFPTSAITCPCFVGRELVVTTADDGEGGAAGAVFRVDVGVGGLGDFEFRLERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIH4</accession>
    <name>A0A194XIH4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_772659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074318.1">
        <property type="nucleotide sequence ID" value="XM_018221913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIH4"/>
    <dbReference type="STRING" id="149040.A0A194XIH4"/>
    <dbReference type="GeneID" id="28831639"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_772659"/>
    <dbReference type="InParanoid" id="A0A194XIH4"/>
    <dbReference type="OrthoDB" id="3238762at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 16" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ19963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="23775" checksum="588401204AD57CBE" modified="2016-10-05" version="1">MGTSRRVRCYIPITNKIFISVDEAGTCARLPLNNNPVTSVTTTDIECNAGTKPVATLCPVTAGQNITVEMHAQPNDRSCTTQAIGGNHYGPVLVYMGKVADAASGMPTSWFKIAEDGYSPTTKKWGTDLLNDNCGKRSVQVPATLAPGNYLVRAEAIALHAASSTGGAQFYMTCFQVNVASTGTVNPPGVAFPGAYKATDPGILINIYQASNIANYQIPGPAVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ56</accession>
    <name>A0A194XJ56_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_773003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074514.1">
        <property type="nucleotide sequence ID" value="XM_018221921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ56"/>
    <dbReference type="STRING" id="149040.A0A194XJ56"/>
    <dbReference type="GeneID" id="28831647"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773003"/>
    <dbReference type="InParanoid" id="A0A194XJ56"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="17641" checksum="6532BED3BCB62713" modified="2016-10-05" version="1">MGNSLTVDQMAKIKAFTREQVEEFKRVFTLVDKNNDGNITTTSLGSVMRSLGQTPTDAELLDIINEADTDHDGTIDFPEFLAMMATKSKAVDTEAEIRAAFTVFDRNGDGVISAAELREVMASIGEKLTDAEVEEIVREVDRDGDGGIDFEEFLQVLNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJQ1</accession>
    <name>A0A194XJQ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_579487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074694.1">
        <property type="nucleotide sequence ID" value="XM_018209005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJQ1"/>
    <dbReference type="GeneID" id="28818731"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579487"/>
    <dbReference type="InParanoid" id="A0A194XJQ1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="158" mass="17505" checksum="DFD853F68EF7A248" modified="2016-10-05" version="1" fragment="single">LYIAQAQLADLPLALQADLPTPRLVTEAGKGDIYDANLWMGIPPTYTPLHKDPNPNLFVQLASRKRVRLFSPRIGMEIFRAVQMRIGRSGEGSLRGDEMMEGPERGELERAVWGEGGGDGGFEGLVEAGDALFIPRGWWHSVKSEAEGVNASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJX5</accession>
    <name>A0A194XJX5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_578999</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074769.1">
        <property type="nucleotide sequence ID" value="XM_018208981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJX5"/>
    <dbReference type="FunCoup" id="A0A194XJX5">
        <property type="interactions" value="1210"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJX5"/>
    <dbReference type="GeneID" id="28818707"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578999"/>
    <dbReference type="InParanoid" id="A0A194XJX5"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="134"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="256"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ20414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="399" mass="43746" checksum="AE8CB5BE9A93CB3A" modified="2016-10-05" version="1">MSHINGSNGTNGHKVHHNQGTFLFTSESVGEGHPDKIADQVSDAVLDACLAVDPLSKVACETATKTGMVMVFGEITTKHNIDYQKVIRNAIKDIGYDDSAKGFDYKTCNILVAIEEQSPDIAQGLHYEKALEQLGAGDQGIMFGYATDETPELFPLTLQLAHKLNAEMAASRRDGSIPWLRPDTKTQVTIEYKHDNGAVVPLRVHTVVVSAQHAESISTEQLRKEIKEKIIKKVIPAKYLDDETIYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYLARWIAKSLVNAKLCRRALVQLSYAIGVAEPLSIFVDSYGTSNLSSDELVEIINKNFDLRPGVIVKELDLAKPIYFQTAKNGHFTNQNFSWEKPKTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK94</accession>
    <name>A0A194XK94_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_448886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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</entry>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="30953" checksum="46ACC25A3F5748A4" modified="2016-10-05" version="1">MSNIKYETELHDFPNIFSLKGKVVVVTGGSRGLGLHAASGFLQAGASKVYITSRKASACQQACDTLNALPNLSPSARAIPVPADSSKIEGIEYLVKEVGKTTDHVDVLFANAGATWGESFDTHPDSAFAKVMDLNVKSVFNTIRLFAPLLQKNGTIQDPSRVIITASVAGIGIGTLGKQATFGYSASKAAVIHLAKNLAVELGPRHVLVNAIAPGFFPSKMASGLMEISGGVESLSKKNPSQRLGRPEDIAGLVVFLSSRASAHINGATITVDGGEVWARGGMAELKEEPEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM38</accession>
    <name>A0A194XM38_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_430873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075598.1">
        <property type="nucleotide sequence ID" value="XM_018207471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM38"/>
    <dbReference type="GeneID" id="28817197"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_430873"/>
    <dbReference type="InParanoid" id="A0A194XM38"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ21243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="27633" checksum="03D31D711B7C42CE" modified="2016-10-05" version="1">MSEPRDENPKGTSVLLLQDARPESEKSLHTAPEKSYLSTPSTISVTSPSGSDIDLVESTASEIEMASPVTTSPMVAARSLQANPRKRMQGYDDYQSELVRQSRSSFPNNNLPCLWEQCGIVFSSSTERRNHVRSHTINAVDCRWPGCARSFEGRASLNKHLDTHIKPHACPNPTCQHTAATPRDLERHMDTHQRLLGYYCPIDSCRASRSSSKPAFSRLDNAARHIKRIHPGSSAIPRPKLGAVHNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMD9</accession>
    <name>A0A194XMD9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_639329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075698.1">
        <property type="nucleotide sequence ID" value="XM_018211614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMD9"/>
    <dbReference type="GeneID" id="28821340"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639329"/>
    <dbReference type="InParanoid" id="A0A194XMD9"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="15"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="57844" checksum="115ED9AD63EF4AD7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNN5</accession>
    <name>A0A194XNN5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_681140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076074.1">
        <property type="nucleotide sequence ID" value="XM_018214213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNN5"/>
    <dbReference type="GeneID" id="28823939"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681140"/>
    <dbReference type="InParanoid" id="A0A194XNN5"/>
    <dbReference type="OrthoDB" id="3504584at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17796" checksum="85325A20E301929D" modified="2016-10-05" version="1">MGERIGGSGLNATSIAAVNINSTTNNINLFYVDSLSENLYNMQFTNGAWTTPLPVAHRSFDAWNPFAGLGAAYSVGLDQLQVFFTGLDQRIYQYIGSNASQTTSTSWSQQPSSQRLWSNADYVGADITAVGWKNQIRFFQISQGKMAQGTLNNQTWSETFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT2</accession>
    <name>A0A194XNT2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor, CC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_694310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
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    </dbReference>
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        <source>
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        <source>
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        <source>
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</entry>
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    <accession>A0A194XPQ3</accession>
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        </submittedName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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</entry>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="550" mass="60409" checksum="A91F2CFDD4E6590A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRS1</accession>
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            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="13" type="ORF">LY89DRAFT_703677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077345.1">
        <property type="nucleotide sequence ID" value="XM_018217338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRS1"/>
    <dbReference type="FunCoup" id="A0A194XRS1">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRS1"/>
    <dbReference type="GeneID" id="28827064"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703677"/>
    <dbReference type="InParanoid" id="A0A194XRS1"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="481"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="979"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1032"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ22990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128736" checksum="0E951C3DE90454AF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRW8</accession>
    <name>A0A194XRW8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077251.1">
        <property type="nucleotide sequence ID" value="XM_018219332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRW8"/>
    <dbReference type="GeneID" id="28829058"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729003"/>
    <dbReference type="InParanoid" id="A0A194XRW8"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="550" mass="61737" checksum="2F8505B81EFAB1B0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS22</accession>
    <name>A0A194XS22_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_574336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077348.1">
        <property type="nucleotide sequence ID" value="XM_018208736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS22"/>
    <dbReference type="FunCoup" id="A0A194XS22">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XS22"/>
    <dbReference type="GeneID" id="28818462"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574336"/>
    <dbReference type="InParanoid" id="A0A194XS22"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="31362" checksum="A09F872CEF58A86F" modified="2016-10-05" version="1">MGAPGLNQRKKVTINSLRSLYKKGEPITVLTAHDFPSAHVAEAAGMEIILVGDSLAMVALGMEDTSEVLVEEMLLHCRSVSRAAKSAFTVGDMPMGSYEIAPEQALETAIRFVKEGRVQGIKLEGGIEMAPTIKKITSAGIPVLGHVGLTPQRQNALGGFRVQGKTSAGALKVLEDALAVQEAGCFATVLEAVPQEVATLVTKKLSIPTIGIGAGNGCSGQVLVQVDMTGNFPPGRFIPKFVKKYGDVWSESLRAIEAYRDETKSRAYPAPEHTYPISKEELAEFERVIGANDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTA5</accession>
    <name>A0A194XTA5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_777137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077731.1">
        <property type="nucleotide sequence ID" value="XM_018222114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTA5"/>
    <dbReference type="GeneID" id="28831840"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777137"/>
    <dbReference type="InParanoid" id="A0A194XTA5"/>
    <dbReference type="OrthoDB" id="10503888at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24261" checksum="3F27722543B3CBA7" modified="2016-10-05" version="1">MPARTYPRSISNERKDETRRHGPSFSSTPTIGRVRTSGGVIASTSPTTVDKAKSNSRPSSHQRRPRRQQALRPSPPPSHQKYPEAAAYDLTSHTLASAQSHYQSASVPGLPSAAKWPHHSSVADRKSMDDDLLGLGVDQFKYDPYSRTARISEEDFESTPNEGYLAGNLSSRSFKVVGRYGMTIDGGVQGAIFAWDQAETLLTRRGYSYDSVDRTDETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTB9</accession>
    <name>A0A194XTB9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077746.1">
        <property type="nucleotide sequence ID" value="XM_018214021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTB9"/>
    <dbReference type="STRING" id="149040.A0A194XTB9"/>
    <dbReference type="GeneID" id="28823747"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680144"/>
    <dbReference type="InParanoid" id="A0A194XTB9"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF25">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="97"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="29353" checksum="EDDB9F98510D806C" modified="2016-10-05" version="1">MVVLDWELFPEGWSFTGRDGTDPVDPLYGFARLSQLYFKAEPSYSARYTVPILWDKKKETIVSNESSEIIRMFYSEFDSLLPESLRESSKPNGGFLPKNLLKEIDEMNTWVYDQINNGVYKTGFAVTQEAYETNVRVLFSALDRIETHLSSHGPYLFGEHITEADIRLYPTIARFDVGYHTLFMCNLKMIRHDYPRIQEWYERLYWDESEATRGAFRKSTYFDAIKKGYTKASRRTIVPLGPEVEMLPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTR5</accession>
    <name>A0A194XTR5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Probable beta-glucosidase E</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Beta-D-glucoside glucohydrolase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cellobiase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Gentiobiase E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LY89DRAFT_187651</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077958.1">
        <property type="nucleotide sequence ID" value="XM_018205680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTR5"/>
    <dbReference type="STRING" id="149040.A0A194XTR5"/>
    <dbReference type="GeneID" id="28815406"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_187651"/>
    <dbReference type="InParanoid" id="A0A194XTR5"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="22">
        <location>
            <begin position="881"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KUJ23603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="966" mass="105174" checksum="D90A683450DD7849" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV28</accession>
    <name>A0A194XV28_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_680296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077917.1">
        <property type="nucleotide sequence ID" value="XM_018214045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV28"/>
    <dbReference type="FunCoup" id="A0A194XV28">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XV28"/>
    <dbReference type="GeneID" id="28823771"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680296"/>
    <dbReference type="InParanoid" id="A0A194XV28"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="22713" checksum="4136BCE4DBDE9D7F" modified="2016-10-05" version="1">MSNPRIEELPDDEPTKNVTAEDEGSESSDSDVEAGEGGIPAGGAIVHSRNEKKARKSIMKLGLQKVPGITRVTLRRPKNILFVINNPEVYKSPSSNTYIVFGEAKIEDLNSQAQASAAQQLAAQEAHDHAGHDHSGHDHSGHDHGKGKAIDTGDDKKDEDEDDGEEVDASGLEDKDIELVMTQASVSRNKAIKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVW1</accession>
    <name>A0A194XVW1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_663029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078631.1">
        <property type="nucleotide sequence ID" value="XM_018212682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVW1"/>
    <dbReference type="GeneID" id="28822408"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663029"/>
    <dbReference type="InParanoid" id="A0A194XVW1"/>
    <dbReference type="OrthoDB" id="5331848at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
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        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="283" mass="31181" checksum="390A6787C571712B" modified="2016-10-05" version="1">MNYICMGVATSYGVGRHAYCLTTNNLVSAAKWNFTADPFGIMAVVVPKLAVVALLNSLVSAFKKKGIYFLWFCVISNIIFSIVAAIVLFAQCDPPSSLWNVAIPHKCWKPRIVADYSMFCGAWSAFNDLILALYPISLFYNLQMALWKRIAVCGLLGLGVFDPDREACSSPKLFRCDLGFIRNSDLGGAGAEANVIIICACVPTLVPLVRQITGRRDYILERTRGTSQRTLKNEVSLRDMNTNTIESGNDSQSKFNGFDPINENRSTNGSSSREDAAGKWHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2D6</accession>
    <name>A0A132B2D6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_415448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947451">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28817091"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_415448"/>
    <dbReference type="InParanoid" id="A0A132B2D6"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="116" mass="12652" checksum="93D092AD16B5B95B" modified="2016-05-11" version="1">MESRTQIASITPSTSALSLKSLFYLVFVIEMRKGKSARGPSSLAKRALASSLTIVLVGCGNRLSPRCQEGYSTTISVRDKRMWSAWPDKLKKVKLLASLDSSISQDSTPLLKCSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2J0</accession>
    <name>A0A132B2J0_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
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    <gene>
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    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="28822356"/>
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    <dbReference type="InParanoid" id="A0A132B2J0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
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    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="517" mass="59092" checksum="1C83D9285EACDEFD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B304</accession>
    <name>A0A132B304_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_726194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061131.1">
        <property type="nucleotide sequence ID" value="XM_018219037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B304"/>
    <dbReference type="STRING" id="149040.A0A132B304"/>
    <dbReference type="GeneID" id="28828763"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726194"/>
    <dbReference type="InParanoid" id="A0A132B304"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF107">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ06776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="528" mass="59758" checksum="5D661CA395A54CF9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B306</accession>
    <name>A0A132B306_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_401105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060988.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B306"/>
    <dbReference type="GeneID" id="28816988"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_401105"/>
    <dbReference type="InParanoid" id="A0A132B306"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24293" checksum="7C2A00A54852D3BA" modified="2016-05-11" version="1">MGANLVRKAALTPLEEEDTCENHSRIMRIIPLAALSTISIQLSVVAECGRLQLISTPQLPYIGALNIGYHNPDFEDSQSSPRWNIRYHNQCLTRGRYGVLQQSCWALNGLTSTFALLVEPPRTPAQHGGPPHADSGHHCTLGKSFSHSVRVFHPIWLFMQGNHIVQPPRFSRIINSGVEDARRVSAPCLTKGGEDILLHGLHLNKNLPDPYQSQTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4J8</accession>
    <name>A0A132B4J8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061685.1">
        <property type="nucleotide sequence ID" value="XM_018220902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4J8"/>
    <dbReference type="GeneID" id="28830628"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742965"/>
    <dbReference type="InParanoid" id="A0A132B4J8"/>
    <dbReference type="OrthoDB" id="3440156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41759" checksum="1E6F59228D18D605" modified="2016-05-11" version="1">MSHSTRPRNQPLDHLPTNRNAANKHELVRLARNSDVFDGEETQQQTKQDKDGRQAQQEVKEDAVAALMSGKVGDTYLSSKNDENPRLADPGLSPELSQDKLVSHSDRCSDDELNNPVSDDDGKLRPAVLMHKKRKHHPEQRSTRRHGPHSKPIGTLRNLTPLMTSVRESPQYPVMADSRGQDTAHRSVMKTRMKRTRRSNRERSGGTRTGLRRPAAASISPRADHGHPPTLAGDGQHHHHPPRASRSLSAAVKSAPLAEYQEWPFQGFPKRTRIRSETTYNLEFQLLHIPEHLHLSMLSEALGMCSDVRRGCNPSRHWRTFQDASVRPRIKRVRWTPKEDATILKMREVDSCSWEEIHADQFMSLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V8</accession>
    <name>A0A132B4V8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_743062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061797.1">
        <property type="nucleotide sequence ID" value="XM_018220916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4V8"/>
    <dbReference type="GeneID" id="28830642"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743062"/>
    <dbReference type="InParanoid" id="A0A132B4V8"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47849">
        <property type="entry name" value="CHITIN-BINDING LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287866" description="Chitin-binding type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
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            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="134"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="38847" checksum="1B42C86E31DBE4FA" modified="2016-05-11" version="1">MRAPFIVLPLLAIGVASDSILESLGFGMLESGSLLQKYSRLLRRQSSSNGTCRLSLQTDIWTSCAALLSEFNLTLDYFKSANPNIGANCANFQPGATYCLSVPSGSPIPVSTNGLCGAQQNWTNTCIGSSAGACCGIGGFCGTGEIFCGLGVCQEGTCDGAPIPYSTDGTCGSQIQWTECPPQFGDCCSEFGFCGNGTTFCGTGCQSGTCTDSTVTTTTTTTSAHPTQTAGSISTDGTCGFSGGLICKGSTFGSCCSSAGYCGSTEYACLDILGCTASVPTSSSAAATKTSSGTTTIIFSTAPGPTQTGIAANCNAWVLQTPGLFCADLATEAGISLSLFYTLNPAVNNAKGDCQGLLAGDAYCVGTTTTSSSVNEQHGNVNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B546</accession>
    <name>A0A132B546_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061891.1">
        <property type="nucleotide sequence ID" value="XM_018216375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B546"/>
    <dbReference type="STRING" id="149040.A0A132B546"/>
    <dbReference type="GeneID" id="28826101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691624"/>
    <dbReference type="InParanoid" id="A0A132B546"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="758" mass="82629" checksum="3D32D583CC84CCAE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5R9</accession>
    <name>A0A132B5R9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_743236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061589.1">
        <property type="nucleotide sequence ID" value="XM_018220934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5R9"/>
    <dbReference type="GeneID" id="28830660"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743236"/>
    <dbReference type="InParanoid" id="A0A132B5R9"/>
    <dbReference type="OrthoDB" id="5398388at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF18">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="373" mass="41052" checksum="49262FB304EE5C1D" modified="2016-05-11" version="1">MEALPPVSGWHTSLSVTIFVVCVVFAILTILFTVLRFIARSGKLATYGPDDWVLLCAAILSVAHAIMTAWGAGYGSIGTSVLVMSPLQISTFDKLLFASEFISLAALALVKISVLLFYRRLFSVTRFPIIANVVIGIIIAWFIAFFLVMLFAGDPISDSWTHLGHPRYNVAAMLVASSYTDIIIDIAVLALPIPLIKGLHLDTKRKLSVVGIFSLGLFCVVASSVRLHYFVQFSHLYTGENYDGFSRTVTLIFLWSNIEPCCSVIAACLPTLAPLFKDSHFGFFSRLRSYFSSRRSLASSTGEKKATLHQQQPFGRNSDSSVSNSSMPPRADWAPKISTSAYASAAPREDFDLERQEAAYGREIRVKSTTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B683</accession>
    <name>A0A132B683_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_711927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062118.1">
        <property type="nucleotide sequence ID" value="XM_018217940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B683"/>
    <dbReference type="GeneID" id="28827666"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711927"/>
    <dbReference type="InParanoid" id="A0A132B683"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="429" mass="47766" checksum="FB00D852B593E10E" modified="2016-05-11" version="1">MAQLDTNGKEGEVLHLEKVEAAPIKSSIFTQEDDLGAKRLERRLKWKLDLFILPLVSMVYFFASLGRSDLSNTKISGLDEQLKLSAKDYSNAANMFLVGYVVFQLPGTLLIKKIGPPIQFGIAMFMWGVFTTVSVAMTNRSQLMALRFLIGAAEAFIQGAVFYLSFFYEYSELATRGAIFFSTSTLAGSFSGLISYGVVENLNGAHGWLAWRWIFLIEGVLPVGATLLVIFLLPSTPEKLGRNFKEDERELAIQRSRRAHYEETTKLDWKLIHTPLLSVHFWIFVLLYCASHFCISSLQNFLPAIIKGFGYSGADAQLFSVAVYACAFFGVIFWARVSDCTNRRGWTTAAANVFAVLGYALLLGLTGTKARFGATCLLAFGAFANIALQLTWMTMTFVGYTRRKFSIIGIFSDLRSRPTGIELVLGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6F8</accession>
    <name>A0A132B6F8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_742281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062340.1">
        <property type="nucleotide sequence ID" value="XM_018220805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6F8"/>
    <dbReference type="STRING" id="149040.A0A132B6F8"/>
    <dbReference type="GeneID" id="28830531"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742281"/>
    <dbReference type="InParanoid" id="A0A132B6F8"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="423" mass="47347" checksum="98FBFF38C45D77E2" modified="2016-05-11" version="1">MPTRPWRIPLPPTRLQNSSESPTSPASPLSPPSSTSPRSPKGPLTAPPRLHLRTIIPSPPLPVEYLKTAPSAPYPWIWRCHLCGSIYRLGATRRCLEDGHYFCSLPSPPPSPAVPTSEDFFSVLHSSEPSSKTGKEIIADLAANKKRSKSRRRKGTRGCRSEFDYAGWSKYNIWRREVAVLKREQKKKFLTRSLAEGLREGIATREKAERSWKGRDCWKDCDFPSECHNERKAEREWERQMKEIRESEERWARENEWNEEGDAGRPDSAMGLGGEDLLLESIELDGLEDKKAPGDISEEVVDGTENLGPLGTDCDGLGEQVVQAEYTTKRRKSMDAAMASDSPPSSPLKECSFGFENPATRCQVWSSAGLCSCAKNGEEEEYSKDEDGDVQIKEVSMAKSLLLRKAEKDVADETFGDEDVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B982</accession>
    <name>A0A132B982_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_690532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063317.1">
        <property type="nucleotide sequence ID" value="XM_018216116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B982"/>
    <dbReference type="FunCoup" id="A0A132B982">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B982"/>
    <dbReference type="GeneID" id="28825842"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690532"/>
    <dbReference type="InParanoid" id="A0A132B982"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="192" mass="21526" checksum="8FE4A81DF37C6B02" modified="2016-05-11" version="1">MPAYNSIFNADSSPPSCTNIGNFPLLPLRTKVRGPAYTLPPSSLAAHLSPEPDSESYDALDEVLGLFRANTFFRNFEIQGPADRLLIYGILWVSECLGKIRSGMGAREAQKEVQNIALDTNFAIPGDPGFPLNQMFNPPRDRQEAETLKQYLGQLRQELASRLLARIYEDGSEKPSKWWLSFAKRKFMGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9E6</accession>
    <name>A0A132B9E6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_764630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062849.1">
        <property type="nucleotide sequence ID" value="XM_018221644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9E6"/>
    <dbReference type="GeneID" id="28831370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764630"/>
    <dbReference type="InParanoid" id="A0A132B9E6"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="107"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="606" mass="68354" checksum="118FCC74A47A65C9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9M9</accession>
    <name>A0A132B9M9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_701579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063465.1">
        <property type="nucleotide sequence ID" value="XM_018217210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9M9"/>
    <dbReference type="FunCoup" id="A0A132B9M9">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9M9"/>
    <dbReference type="GeneID" id="28826936"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701579"/>
    <dbReference type="InParanoid" id="A0A132B9M9"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="630" mass="71609" checksum="4134DB997B103ED8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9S8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_763817"/>
    <dbReference type="InParanoid" id="A0A132B9S8"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ09162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="22026" checksum="353E345AF54339AE" modified="2016-05-11" version="1">MAPYLNVGGLNSTFAILQDVPPPSGTIRVLSRTRKTYNKKLIQSQVVPAVRQFITQHSKADLSAITGTLTAFFDSALKDYGARNAGEMAKAQAWVFITISKINSYGKHYWHRDGICGLENGRVLSRYSMAMVGPPTEVICSSEPQLGLELHHAQKGLESLPRHPIATGQVYRFTTGQGDSPIHSTPVFKTGRIFVSVIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAH4</accession>
    <name>A0A132BAH4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_281988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063618.1">
        <property type="nucleotide sequence ID" value="XM_018206464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAH4"/>
    <dbReference type="GeneID" id="28816190"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_281988"/>
    <dbReference type="InParanoid" id="A0A132BAH4"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="250" mass="27748" checksum="98C87B69C64A37A6" modified="2016-05-11" version="1">MAAVKPFSIPGFNKALKVQDLEESCNIYNMLPTDSQQPEILESHIHNLAALFVQNRAEKILGIHLAHGHFAAPKHTAMLGVNYEEPYCRWARPTAIQTIDLSNVHGHIFVLTDHGFHPYEYQSGPAPDLSELDSAFLPNLADYLNKNDLSMLVGLQVVDQNPANMLELILPQGTVMLDSSVLNGCVPTRQTGWKFESEDSKPRVCQANETHGQHANGHDIYNKGDPHPKLETFEDVRIALVEAGLLDQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB22</accession>
    <name>A0A132BB22_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_658117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063399.1">
        <property type="nucleotide sequence ID" value="XM_018212460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB22"/>
    <dbReference type="FunCoup" id="A0A132BB22">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BB22"/>
    <dbReference type="GeneID" id="28822186"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658117"/>
    <dbReference type="InParanoid" id="A0A132BB22"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="131"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="573" mass="62612" checksum="07FE3C459EA48A63" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB30</accession>
    <name>A0A132BB30_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_690066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063951.1">
        <property type="nucleotide sequence ID" value="XM_018216024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB30"/>
    <dbReference type="GeneID" id="28825750"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690066"/>
    <dbReference type="InParanoid" id="A0A132BB30"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="636" mass="71836" checksum="CDE0ED06AF9C76DE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBC5</accession>
    <name>A0A132BBC5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_541834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064070.1">
        <property type="nucleotide sequence ID" value="XM_018208186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBC5"/>
    <dbReference type="GeneID" id="28817912"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541834"/>
    <dbReference type="InParanoid" id="A0A132BBC5"/>
    <dbReference type="OrthoDB" id="3562353at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="103" mass="11549" checksum="4D2F28AD6DC2881B" modified="2016-05-11" version="1" fragment="single">LHIDDEAGELAAQALATGPAETEISNRVLRKVDLYILPFLCITYGLQFLDKTTLGYSSVFGIITDNHLVGQDYSWTSSIFYFGYMFAEYPGVALLQRFPIAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBN0</accession>
    <name>A0A132BBN0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_597643</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064185.1">
        <property type="nucleotide sequence ID" value="XM_018209988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBN0"/>
    <dbReference type="STRING" id="149040.A0A132BBN0"/>
    <dbReference type="GeneID" id="28819714"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597643"/>
    <dbReference type="InParanoid" id="A0A132BBN0"/>
    <dbReference type="OrthoDB" id="3562858at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="195"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ09830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="275" mass="29875" checksum="16012A80E793EA42" modified="2016-05-11" version="1" fragment="single">FLNAWSGEGGDRSELYNATQDTLVNTVADNCNNTIVVINTTGPRLVDQWITHSNVTGVLYGGPLGQESGNAIDDILFGAVNPSGKLAHTIAKNESDYDANTQITESLEIDFSEGNYIDYKYFDKYNVTPRFEFGYGLSYTTFNYSEQVTVTSNATALAQAYATGALAVGEREDLWDVVATVSSSISNTGDVAGAEVAQLYVAFPDAADEPVRQLRGFDKVMIQPGESEAVSFELKRRDLSVWDVGAQAWKIESGEYVFYVGASSRDLRASATLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC11</accession>
    <name>A0A132BC11_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_724692</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063552.1">
        <property type="nucleotide sequence ID" value="XM_018218921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC11"/>
    <dbReference type="FunCoup" id="A0A132BC11">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BC11"/>
    <dbReference type="GeneID" id="28828647"/>
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    <sequence length="937" mass="101866" checksum="3F2FAA0A950974FB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDK3</accession>
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        </recommendedName>
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="156"/>
            <end position="186"/>
        </location>
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            <begin position="339"/>
            <end position="370"/>
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            <begin position="156"/>
            <end position="169"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="517" mass="58303" checksum="525FE76535BB903F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSJ3</accession>
    <name>A0A194WSJ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_595545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10928.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35603" checksum="8378CD1B0A646FF6" modified="2016-10-05" version="1">MFWRTAIVQSSKSASQPEWSGWEDIKYTFIFGDSWTDTAFDPQGTQPNPGNPLGNPDFPGRNAANGTNWVGFLSTKYNESFLQTYNLAVSGATLDNSIVQGYPNPISVQVYQRFMSHYGDGHSPPWSASNSLFIMWAGIVDLVMMNGVHDPEALSHINGNLTIVYSRLLNTLYGAGARNFLLLNEPPLERTWQPAEKEKIKAKFASDVAIYNQRVKNAAFDLKKTFPDSNVFHLNTNDLFNQALDDAKAFPQTSGILNTTDPCPEYQSGTPTSDYYDPKCRIPVNQYFWLNGLHPTYPIHDVLAEHIAKLLKQGPNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSL4</accession>
    <name>A0A194WSL4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSL4"/>
    <dbReference type="GeneID" id="28825643"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689488"/>
    <dbReference type="InParanoid" id="A0A194WSL4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="81" mass="9245" checksum="BFE4226AA6D488DF" modified="2016-10-05" version="1">MQLYQMFSSSLRVEEIIRIFFLIDKGYVERGMMKPSQVEFTNVRPSCNISTQSLDIAKPFATSGVVQELVDIASSKLRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT12</accession>
    <name>A0A194WT12_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_787149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065117.1">
        <property type="nucleotide sequence ID" value="XM_018223044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28832770"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787149"/>
    <dbReference type="InParanoid" id="A0A194WT12"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="38"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="879"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1420"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1469"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1522" mass="168574" checksum="B195A1FFCE98004A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTY6</accession>
    <name>A0A194WTY6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolar complex protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_710304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065504.1">
        <property type="nucleotide sequence ID" value="XM_018217820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTY6"/>
    <dbReference type="FunCoup" id="A0A194WTY6">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WTY6"/>
    <dbReference type="GeneID" id="28827546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710304"/>
    <dbReference type="InParanoid" id="A0A194WTY6"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="315"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="542" mass="61713" checksum="6EFD30D7EDE3E237" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVJ8</accession>
    <name>A0A194WVJ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_594325</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066049.1">
        <property type="nucleotide sequence ID" value="XM_018209793.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194WVJ8">
        <property type="interactions" value="850"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVJ8"/>
    <dbReference type="GeneID" id="28819519"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594325"/>
    <dbReference type="InParanoid" id="A0A194WVJ8"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="147"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="462"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1333"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="468"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1477" mass="165858" checksum="B0325CCE74C8B7EE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW32</accession>
    <name>A0A194WW32_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_786309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066535.1">
        <property type="nucleotide sequence ID" value="XM_018222970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW32"/>
    <dbReference type="STRING" id="149040.A0A194WW32"/>
    <dbReference type="GeneID" id="28832696"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786309"/>
    <dbReference type="InParanoid" id="A0A194WW32"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="259"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="642" mass="71419" checksum="93C64DE861D5040F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWH3</accession>
    <name>A0A194WWH3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent leukotriene B4 12-hydroxydehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066681.1">
        <property type="nucleotide sequence ID" value="XM_018220328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWH3"/>
    <dbReference type="GeneID" id="28830054"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738114"/>
    <dbReference type="InParanoid" id="A0A194WWH3"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="38196" checksum="1FC417DA0BCBB00A" modified="2016-10-05" version="1">MVQNKQLIFASHPTGFPIPGTDLKLTTTELDINSPPPGGLIIAPKYVGYDPYMRGRMRPAGALYISGFQLNEPLYNFAISTVISSSCPRFKPGDILLGSAHFAQYQVIEKEKAEKSEADGGFDILQNPLGLDLMVFLGPLGMSGLTAYSSFYEIGKPKKGEVIFISAASGAVGQVVGQLAKREGMVVIGSAGSDEKVKFVVEELGFDKGFNYKTEKPGEALKRVLGELGKDGLNIYYDNVGGETLDAALGVMSTFGRIVSCGSVSQTSKKPEDTYGIKNMPMVTGKRLTIRGFIVFDPDFGPKYHDEHQKNVQKWIKDGEIQVKLSVTEGIDNAAGGFVGMLKGENFGKALVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX31</accession>
    <name>A0A194WX31_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_209780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066896.1">
        <property type="nucleotide sequence ID" value="XM_018205859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX31"/>
    <dbReference type="GeneID" id="28815585"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209780"/>
    <dbReference type="InParanoid" id="A0A194WX31"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="288" mass="32302" checksum="27E267D4A641156C" modified="2016-10-05" version="1">MAGDRLLNRAFATQHLPSFFIWSCEVLHISQRQPRAYTPLVLNHLPEDSFQVSCLLNSSLGDKQVLDNPSRLRSRKLFQMTVLGPQAKTCLQDVNIPAYTLTSLELPFPSHHSCSACIRKAPSSCPAFTRALTVQSRCILNPLSIAPITERVRNATILRTFLRKSTNAAVPTCFLLSIGRVVVAHRALLEVKWHTKQHLHVLSADDRSYAPIISFTFPLSSFLTCTTCPNECENRLTNIFKELAKLRLIEISTDAICSHGMTFHENLSSESRFPTEMGSRQPAVHVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX82</accession>
    <name>A0A194WX82_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_653945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
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        <property type="protein sequence ID" value="KUJ12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066552.1">
        <property type="nucleotide sequence ID" value="XM_018212274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX82"/>
    <dbReference type="STRING" id="149040.A0A194WX82"/>
    <dbReference type="GeneID" id="28822000"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653945"/>
    <dbReference type="InParanoid" id="A0A194WX82"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="266"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="49392" checksum="79DC04AE9071F7D0" modified="2016-10-05" version="1">MVIKRNEPCYVLGVGMTKFIKPRGKVDYTELGFEAGIKAMLDAQINYDDVDQGVACYCYGDSTCGQRVFYQFGMTQIPIYNVNNNCSTGSTGLHLARNVISHGGADCILVVGFEKMNPGSLQSFWQDRSNPTGTSGEMMAATRGVTNAPGAAQMFGNAGREYMEKYGAKPEDFAEIARVNHEHSQRNPYSQFQDVYTLEQIMKAPMIHEPLTKLQCCPTSDGGAAAVLVSQDFLDARPHLKEQAILIAGQCLATDAPSLFSRSSIDLMGFEMTQYAAKTAMDEAGVSPKDIKVCELHDCFSANEMIVIDALGLSPPGKAHELVRNGDITYGGKLVINPSGGLISKGHPLGASGIAQCAELVWHLRGWANNRLIKDTTVALQHNLGLGGAVVVTVYKRADGKSNDIVDDATIGKKNKLGYNPAVVAKGFTNAQATSVRSRTKSSAWALGDAEKKVEARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXM1</accession>
    <name>A0A194WXM1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_687649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067035.1">
        <property type="nucleotide sequence ID" value="XM_018215548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXM1"/>
    <dbReference type="STRING" id="149040.A0A194WXM1"/>
    <dbReference type="GeneID" id="28825274"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687649"/>
    <dbReference type="InParanoid" id="A0A194WXM1"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="545"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="610" mass="65209" checksum="65DB58E5440FEC9D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY60</accession>
    <name>A0A194WY60_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_209564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066887.1">
        <property type="nucleotide sequence ID" value="XM_018205854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY60"/>
    <dbReference type="GeneID" id="28815580"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209564"/>
    <dbReference type="InParanoid" id="A0A194WY60"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13065" checksum="C63345617D422A88" modified="2016-10-05" version="1">MVNHLFSQVSNPGGHSPLSTLFARVLRRRSRHPISHTEHPCIQHLARPSLGISFSSHHCDNPSKCSVFTKNVPAPLLSTGYHQVRHISFGFQLMPSLPQPAPPSVSPCRAAKVPQPPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZW0</accession>
    <name>A0A194WZW0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathogen-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067838.1">
        <property type="nucleotide sequence ID" value="XM_018215525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZW0"/>
    <dbReference type="GeneID" id="28825251"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687567"/>
    <dbReference type="InParanoid" id="A0A194WZW0"/>
    <dbReference type="OrthoDB" id="65445at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33487" checksum="A172AD40962C3AF9" modified="2016-10-05" version="1">MATADVQAPVEPAAPALPDYLLDPNATLKDNSAKWRYGKAPDYSKTREVYEQTKTKTHEAASLPNLVENLVKNWEVEASFKPNIDDWRTIDRPNYTFSINGGPPQSAEHMLKVGTYNAIITPNDYYDPNKSDFASSHKTFKRMMPTFAWEVLEVYSGPPVVAFKWRHWGVMKNDYAGFNDKGEKIVAKAHGRTLDIQGITIAKVNEKVQLQSVETWFDPMEMFRQISPSGEVTRTKPVPIPGQDISTQLHGEGLGDEEEMDERLEAVSLRGGGASADVLAALHAEMGDMSPAGCPFLARQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0C8</accession>
    <name>A0A194X0C8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_144256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068005.1">
        <property type="nucleotide sequence ID" value="XM_018205338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0C8"/>
    <dbReference type="GeneID" id="28815064"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_144256"/>
    <dbReference type="InParanoid" id="A0A194X0C8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267672" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="80" mass="9053" checksum="8C2BA738277010F8" modified="2016-10-05" version="1">MMPHFGLLFDLLVAPITPLSIDSINIQEDRQSLAPWSDRPSLLFVLPFELVLTMYLCGFPQVLRNRKASPPLTTCPLPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0F6</accession>
    <name>A0A194X0F6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_687505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067707.1">
        <property type="nucleotide sequence ID" value="XM_018215514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0F6"/>
    <dbReference type="GeneID" id="28825240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687505"/>
    <dbReference type="InParanoid" id="A0A194X0F6"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="91"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="37832" checksum="3937D09A4F78FB1B" modified="2016-10-05" version="1">MIPAQANPSERKSDMQTGVSANCLKELNPKENLCDKLHLIVHVSSFTDHRRNSQESSDMATPSRRIITHPNGQTTHVFDDDFTDPWIPRETIVIQHGFARHGAFWYHWVPFLARRYRVIRRDARGHGRSSYPRPGDNYDYSVETVVGEIIDTLDQLRLSKVHFLGESTSGFVGEILAAKHPERLHSLIICSSPAYLPDAALSLFSFGHSSWPAACRTLGSRGWAEALSKVPGTVSIPDPAYIQWWIDQVALSTGEGLAGYAEFLSKADARPYLEKIRVPMLILAPARSAATKLEEQRAIQAQVVNSQLVVIDGQGHEIYVEMAEECQKAVDTFLSGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X252</accession>
    <name>A0A194X252_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_133275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068603.1">
        <property type="nucleotide sequence ID" value="XM_018205254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X252"/>
    <dbReference type="GeneID" id="28814980"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_133275"/>
    <dbReference type="InParanoid" id="A0A194X252"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16572" checksum="C0CF9F03FAE06568" modified="2016-10-05" version="1">MLPPSLLKPPTHHPHLRIVTSPPHSPSPSTAHHFPTQTYNLSIHRQTDTTTDINTKIFASHSTRLTRPFTSRDDTVPPLQHSNTLPFPSTPSLLSPFLPPSFLTSTHKNSQPSPHKPPGPPQKQIPEFHSPTRFTTHPPPPAALTQPNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2H3</accession>
    <name>A0A194X2H3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_736256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068564.1">
        <property type="nucleotide sequence ID" value="XM_018220098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2H3"/>
    <dbReference type="STRING" id="149040.A0A194X2H3"/>
    <dbReference type="GeneID" id="28829824"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736256"/>
    <dbReference type="InParanoid" id="A0A194X2H3"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46368" checksum="7DB808CF435F756C" modified="2016-10-05" version="1">MASLQKGSPLDTLLEIGRTSSVLSPGTIGLFLTLLLWTLYKQATQAQVPKIAKTPEAPDTLPFVGNLMSLGGRLNENDCTIYSRWSKKLGNDIFQMRLGSERALVVNTFAKIKDLWVGHSNYLIDKPQQHGFAKLLEQTHLDIYPYLRQIVFDLALSLTYGTVSSGVDDEFTDALVASINQISYFRASTQRFRDYVPMLRLLVPSFASGNLVASAEKERQKRLDVIYAALKERTAAGEQADCIVNGLVKDNLSEGEIHRTCKALLQAAPDSTASSVYLVIGWFSTPEGREFQDLLYKEILKVYGGDRDKEWKMAFREESVELLVSLYKETLRFWTTTPFAVPRTTVKDVNYAGTTIPKGTTMIMSAQQANHDEAWHGDDAKTFKPARFVGNPTSLPHLTFGAGARICPAAALSNRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3G7</accession>
    <name>A0A194X3G7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_736413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068722.1">
        <property type="nucleotide sequence ID" value="XM_018220119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3G7"/>
    <dbReference type="GeneID" id="28829845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736413"/>
    <dbReference type="InParanoid" id="A0A194X3G7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="52860" checksum="57B8B8D627DD041D" modified="2016-10-05" version="1">MCISLHTNFYHNCGHEQFVLIPSVNPTCPRQLESLRYVENEYCPRCTWKGKLLRFAFPRVWQELGAGIPCQGFTGQVMRTIRMPWYAKYNYTKRTLWQERNRYYRLKFEYIHRKHERNMAAERLEQQRNGESALDWVCFLRASRPGVLNPSPDVYCEFADESGDHLDEISEDRDTCAICQNRTNLGPNDPESCQGSGYIDEAGNMVGGEPVFLLCRHVFGLGCIRQWIEGSETLTQHDTCPMCQNVFEFHREVPYRAPPWWAAAQAYDTLPITGKIMYWPPRLIQLLVVFLTPFWEWCLRVAQIPSTMITGTQQWYATTRVEVARFREWRQILRYDRENFVAWIEVMVDYYVYLTLVSLCLSHPFWLSCTNVLMATIGAATYWWSRPRPLAGEGSERFAAYLIFSFLGNFAEWLIENLMRGWFVRWYDYVWALVYLLCWGRILWAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3R6</accession>
    <name>A0A194X3R6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_123378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069190.1">
        <property type="nucleotide sequence ID" value="XM_018205172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3R6"/>
    <dbReference type="GeneID" id="28814898"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_123378"/>
    <dbReference type="InParanoid" id="A0A194X3R6"/>
    <dbReference type="OrthoDB" id="10629526at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267869" evidence="2">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="206" mass="19690" checksum="D22361820001B0C2" modified="2016-10-05" version="1">MFSNPIIIGLLCLTGVNAQTATETAESGQLLPTQSSLLVSALSAYETSALAASQFSAIASELATATAGPADLLVLAADAIAQDNAGGTSFSAEVASVLSEYPPDVSSWFVSLTMGEQNIVTSVLGTTLVPTGAADDLGGTSSGTGPVVVATATGSGTTVTGTGTAGASKTTSSASKNAGPTLGAMSGAACGVVAFGAAAACAIGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3V0</accession>
    <name>A0A194X3V0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_124090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069215.1">
        <property type="nucleotide sequence ID" value="XM_018205181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3V0"/>
    <dbReference type="FunCoup" id="A0A194X3V0">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3V0"/>
    <dbReference type="GeneID" id="28814907"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_124090"/>
    <dbReference type="InParanoid" id="A0A194X3V0"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903468">
        <property type="term" value="P:positive regulation of DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="79"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ14860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="473" mass="54418" checksum="75897A846089B655" modified="2016-10-05" version="1">MAAIRLRNAKVPFEIHHDEMDPDESFEEQEDLGESRPEGDEEDEQDSDFSDDSDGVVDPSVLEDMEKLEETFKGIKDRFRLINRIGEGTFSTVYKAEDLLYEHYDNDWDIEEKENKWTSPPLKKQRRIGMDALADMDEYAQQRRRPKYVAIKKIYVTSSPSRILNELDLLNDLRGFDSVCPLITAFRHTDQVVAVLPYFRHTDFREYFRKMTVDDMQIYFRSLFTALAAVHSKGIIHRDIKPTNFLYEPDKRRGVLVDFGLAEREDGPDMKPCLCGEGVTERRRRVTNSVAAQTGPIGGYPKNDSRPSRRANRAGTRGFRAPEVLFKCTDQSSKIDIWSAGVILLTILSRRFPFFNSADDVEAMIEIATIFGVKRMKQCALLHGTVFETNIPTIGDRGFLLEKIILWSTCRNDGGKGGSEIPLDAKEKLAVRFLERCFELDPNKRISAEEALEHEFLKKKEEVYGDDDEMHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X402</accession>
    <name>A0A194X402_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_649504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069268.1">
        <property type="nucleotide sequence ID" value="XM_018212064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X402"/>
    <dbReference type="GeneID" id="28821790"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649504"/>
    <dbReference type="InParanoid" id="A0A194X402"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="36"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="49279" checksum="A561A4D367D5FA77" modified="2016-10-05" version="1">MKQEPILRDPSFKLGSISDEDREVFKANVDGVDFRTVTWQRAIIIFIKTQIATGVLGIPSALHTLGAVGGGLCIVGFQALNCYTTIVAGNFRNKHPECHTIVDMAGVLWGPIGREFVGVMFMIAFIFCTASSLLAISIASNALSNHGACSVAFTFVGTVLTVIFSCIRTWGKMTWPLTIGFISVMAGVLVVVIGVTFKSRPAAAPQTGPYELGFYTIAYPSFAAGITAACSIFVSSCGCPGYLPVIAEMRRPQDFKKSAIIVAALVGSIYLSFSMVMYRWCGQWIASPSLGSAGPLLKKVAYGVALPSLVVSAGIFNHTSSKYLFVRLLRNTKHLQADSLIHWSTWIGCNAGVGILAFILAEAIPVFNYILSLEASLFFVPMSLLFPACFWMYEYKHYRIGTFKQKLAYAAHVLLAAIAVFLLVGGTYGTIVSIIDSYKTGGLGSVFSCADNSNTVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X441</accession>
    <name>A0A194X441_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_686463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069179.1">
        <property type="nucleotide sequence ID" value="XM_018215289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X441"/>
    <dbReference type="FunCoup" id="A0A194X441">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X441"/>
    <dbReference type="GeneID" id="28825015"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686463"/>
    <dbReference type="InParanoid" id="A0A194X441"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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            <dbReference type="Pfam" id="PF01602"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14824.1"/>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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            <dbReference type="EMBL" id="KUJ14602.1"/>
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            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114118" checksum="45FAC5F8782DDC59" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X499</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="1 2">CBS 120377</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069564.1">
        <property type="nucleotide sequence ID" value="XM_018212014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X563"/>
    <dbReference type="STRING" id="149040.A0A194X563"/>
    <dbReference type="GeneID" id="28821740"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648419"/>
    <dbReference type="InParanoid" id="A0A194X563"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="245" mass="28439" checksum="55B4A874492076AE" modified="2016-10-05" version="1">MESYSTLNHARLLDTNRSVCEIQFSQILSFIHASPFDPPEHIRQFYSSMRNRRRQHDKFLLHALHESPSLKTFGTEPTSSQIIVSSPFRTRHLVRDFAADVLDILDGARTPVVWILHKPSSDISEQKLITRIEVVKQLVYQILQKNHTMLDERSFSLSAVRFQSARTENEWFALLGSVLAGFKQIYIVVDTALLGEIEEERLTTTWLKRFRELFAELRNRPNSTVVKVLFINYKPTFTQGLAAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X622</accession>
    <name>A0A194X622_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_719351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069978.1">
        <property type="nucleotide sequence ID" value="XM_018218489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X622"/>
    <dbReference type="GeneID" id="28828215"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719351"/>
    <dbReference type="InParanoid" id="A0A194X622"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31108" checksum="72130ED04DC3085B" modified="2016-10-05" version="1">MNRYSRGPTSGPSKASPSTLCQKCLKKGHYSYECKATSQDRPYTTRPSRTQQLLNPKLVPKLTSEAPLLQKKGIADEQLAKADLERGRKRERQSEDPEIRTKRMRSASSASVSTISTNMSRSPSPKPSREPDRSKFRSMSISESPRQQPKSASRSPRSHRQRLSDSEKKRRRDSHSSLDSYSSTERRRSRERESSRSTRRRYQQASPPTRGRRTTESRSPLRERRKLSNDRQREKGDFAVSTNPSNRPPNERSLSPFSKRLALTQAMNMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X681</accession>
    <name>A0A194X681_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_647586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070046.1">
        <property type="nucleotide sequence ID" value="XM_018211965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X681"/>
    <dbReference type="STRING" id="149040.A0A194X681"/>
    <dbReference type="GeneID" id="28821691"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647586"/>
    <dbReference type="InParanoid" id="A0A194X681"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="618"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ15691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="781" mass="85476" checksum="2367A5E655A99A0C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6E1</accession>
    <name>A0A194X6E1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070095.1">
        <property type="nucleotide sequence ID" value="XM_018215135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6E1"/>
    <dbReference type="GeneID" id="28824861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685685"/>
    <dbReference type="InParanoid" id="A0A194X6E1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="16501" checksum="C0E711618B1D192A" modified="2016-10-05" version="1">MASTSELEHVKGVWERMRGNSPIYDFLLSEVEIISAAKGTVTAQLTLGKNHVNSRGTIHGAVSAALVDWSGGLAIATHGLEKTGASIDIHVTYIGTAQVGETIHIESIANKVGRSVAFTTIQISKLVDGKPGPMVATASHTKYISQPAPKDGKDSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6G4</accession>
    <name>A0A194X6G4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_587406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070126.1">
        <property type="nucleotide sequence ID" value="XM_018209429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6G4"/>
    <dbReference type="STRING" id="149040.A0A194X6G4"/>
    <dbReference type="GeneID" id="28819155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587406"/>
    <dbReference type="InParanoid" id="A0A194X6G4"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33985" checksum="12E27BBEC4D82B51" modified="2016-10-05" version="1">MLQPSSFTEPAIDSRPTPTSLRWNPHSRLLELYKLIVGKEEKEPYFQLFEGCAVTNQTPARVYLDYPKAPKKGSYPCQYPWGCSGKQTVFTRPADLDRHYKNVHASPDQKDSFPCDYAPCGRHLDPFTRKDHYRDHLRDYHKEDLGCAKMPKKLGRKVGPAEQAAWLSERKVSRRWWRCARCLVRRQVQVDGWECPNCKSSCEQDRIDARLKKQQHQKAMVVDPTEPDDEVGYQTASSVTTTVPSTAADPSTYYECGTCREYSGWVYDGIGEWNECPDCTTRVAEASYPVDDYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6J9</accession>
    <name>A0A194X6J9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_686183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069782.1">
        <property type="nucleotide sequence ID" value="XM_018215226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6J9"/>
    <dbReference type="FunCoup" id="A0A194X6J9">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X6J9"/>
    <dbReference type="GeneID" id="28824952"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686183"/>
    <dbReference type="InParanoid" id="A0A194X6J9"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="758"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="858" mass="97491" checksum="A3FD5F5365957A13" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7L9</accession>
    <name>A0A194X7L9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_103413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070454.1">
        <property type="nucleotide sequence ID" value="XM_018205025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7L9"/>
    <dbReference type="STRING" id="149040.A0A194X7L9"/>
    <dbReference type="GeneID" id="28814751"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_103413"/>
    <dbReference type="InParanoid" id="A0A194X7L9"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="360"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ16099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="486" mass="53406" checksum="ECECB50BD7081340" modified="2016-10-05" version="1">MPGAIKRRKLATDRHAASVKQTRGLQTFTTTSKAVSVEKSVIEKASHVETIAITSKSSTTTKRKLVDSDEESTPEQSPVSSQTSVREIRSLPSRRSNDVQSLHTPERPILSQDSATSIETPTKGARSLLDRFRISTTTPTRSPLNSSSSSPSILEVSPEKIYLDTPHDLPTELLDLINLHAAFLTALSIHYAHNGTHAPADLRNLCPDVARAWGKRTVTLEDIRRTLGILNTNIPEKYDHRISQLSLSDYGHGKICIEVKTNAGKPGRIARPVNEDLLNNIFAKGLVTTWEGKIVQKSVVAFIEDLPLQPIAICPSLIKMSPLLAKGQRRLDDLRAGMASKDTKERKLAITSTANGTKPSLLERLRAKQLHQSTLAPLPSKAELARKAALGRIDEVVAVLTILSTSNSVGQQRISFTLPTVIGKLKDSFKTPMSREEADTCVRLLAAEIAPDWVKIVKMGKIEALVVNRDERPQETDIKARVQRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X863</accession>
    <name>A0A194X863_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-dependent catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_618719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070342.1">
        <property type="nucleotide sequence ID" value="XM_018210848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X863"/>
    <dbReference type="STRING" id="149040.A0A194X863"/>
    <dbReference type="GeneID" id="28820574"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_618719"/>
    <dbReference type="InParanoid" id="A0A194X863"/>
    <dbReference type="OrthoDB" id="2379805at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08153">
        <property type="entry name" value="srpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024168">
        <property type="entry name" value="Catalase_SrpA-type_pred"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000296">
        <property type="entry name" value="SrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33465" checksum="7825228DB0B734DE" modified="2016-10-05" version="1">MPFSNDEEIMKTAGGLVEQLQAIFGKHPGFRPAHAKGKLYSGTFTPSAKVKELSIAPHFTNAETPVLVRFSNSTGIPNIPDTDPNADPRGIAIRFMIGERKHTDIIAHSVPAFPTRTGAEFLEMLQHLAAGTVGDFLGTHPKALAFVQYPKPPPASFATQQYYGVTAFKLIDSAGKATFIRYHVVPEAGVQILDEEVVKEKGANYLQEELETRLAGGPVSFKILAQIAAEDDVTDDNTVHWPDTRPVVELGSFKVDTIEADSAAKTKYIIFDPIPRVQGVEPSDDPLLEMRAALYLISGKQRRAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8X6</accession>
    <name>A0A194X8X6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_734717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070978.1">
        <property type="nucleotide sequence ID" value="XM_018219936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8X6"/>
    <dbReference type="STRING" id="149040.A0A194X8X6"/>
    <dbReference type="GeneID" id="28829662"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734717"/>
    <dbReference type="InParanoid" id="A0A194X8X6"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="448"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="381"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="679" mass="73926" checksum="4C49C56C6F156FD4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9C4</accession>
    <name>A0A194X9C4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_782045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071125.1">
        <property type="nucleotide sequence ID" value="XM_018222543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9C4"/>
    <dbReference type="GeneID" id="28832269"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782045"/>
    <dbReference type="InParanoid" id="A0A194X9C4"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="175" mass="19841" checksum="EA1178A97257A2D2" modified="2016-10-05" version="1">MDEPISYIPTQHAHLLPSLVKIHMRCIMEPPYTPATFLPPLNEEVMTSWWQDRAKEVEKDQRVIIMQMASNATTGKEEVAGVVMLEMPVTETGPFRGEVQKLLVPPEYRKMGVTSRMMAKLENVAREKGRKLLGNPAEFVYPKLGYIKVGEIPGCDISPLDGSLKTAVYFYKDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9M9</accession>
    <name>A0A194X9M9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_645879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071231.1">
        <property type="nucleotide sequence ID" value="XM_018211897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9M9"/>
    <dbReference type="STRING" id="149040.A0A194X9M9"/>
    <dbReference type="GeneID" id="28821623"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645879"/>
    <dbReference type="InParanoid" id="A0A194X9M9"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="47300" checksum="D5D6590A971DEE28" modified="2016-10-05" version="1">MHHRKAHRKSRNGCKNCKVKRIKCDEVHPRCANCTKYSFDCDFEPRKNEIHVFPLPPVRIATLRRHKSSDSSRTYGDLTPSRCGSETLSNATSTSGLIRADSIMTMNTPSDRLLELRLMHHFTTTRSETYFRFIGSLKSRQLDEHDTCSVWMIDVAMSNPGVMDALLGFSAFNLRHLLPSDRDLCHASHKYTMRAIEAHTQQLQKGISEQNAGILFAGSITIAFIAVDSHQYLAPENNNMLPLHWFQRWEGCRAVVSASWQHLHNKAIARKLVEVEEGARLTAQCLADTSYTKFDFLLEDLDRDGITLETLSAYENNVKWLSILHDNPGVDYIFKFTTRVGPRFVEMLEQGDPRTLTIVGYFFVLLKIRKPVWWLPQPKRKEFLILMDLLPNEWKPRMKWAVKVFEGCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAB1</accession>
    <name>A0A194XAB1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_63047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071057.1">
        <property type="nucleotide sequence ID" value="XM_018211242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAB1"/>
    <dbReference type="GeneID" id="28820968"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_63047"/>
    <dbReference type="InParanoid" id="A0A194XAB1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268006" evidence="1">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="17272" checksum="9734010609120848" modified="2016-10-05" version="1">MRCGPNRNCPCLMLMVAIPQTANASMLYYAQTLIADFIQSAAQAEYASVSVSGCSTFTSVYPSSQSVLDSGAYTFCSCGDDIYGLARGVSGTSTTSWCKGIEATPSGFTQVSTTTHAAKTATQQSINPSAVASSILVIPPPITTTTSTSSTKNPGEPYSLTCAAPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB97</accession>
    <name>A0A194XB97_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_696869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071796.1">
        <property type="nucleotide sequence ID" value="XM_018216866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB97"/>
    <dbReference type="STRING" id="149040.A0A194XB97"/>
    <dbReference type="GeneID" id="28826592"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696869"/>
    <dbReference type="InParanoid" id="A0A194XB97"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268091" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="85"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="683"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="80956" checksum="BA36EC7596C91CDC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBR1</accession>
    <name>A0A194XBR1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071955.1">
        <property type="nucleotide sequence ID" value="XM_018214915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBR1"/>
    <dbReference type="STRING" id="149040.A0A194XBR1"/>
    <dbReference type="GeneID" id="28824641"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684606"/>
    <dbReference type="InParanoid" id="A0A194XBR1"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="46102" checksum="45FC2CF0EC0ABC7E" modified="2016-10-05" version="1">MTLDIDTSKAPTPLPTPRLTKVSSRVSLLSPLSRQGSGPGLIILTSDSKDNLAIKQGVPSLLRKWAEEGYSVVEIQENALQNGKAEELLERAVSALSECEKCEPKGVVGLVAYEPKLWNQVASKLHSFKEIVAAILYASASEVSSLEPSHLPLIRHVAGKFKATRSPQLTDYENPQVSSYLFATPFQDHFNYSAEAVSHTRNLTFLKKHMNGPFFDLEVIWDEHTYFEFENRSVEHTMATMVDEPYVNHIPTITGGIGRENLTSFYAHHFIFKNPEDTELELISRTIGVDRIVDEFIFKFTHQTEVDWLIPGIPATNKRVEIPFMAVVNIRGDRLYHEHIAWDQGTVLAQLGLLPEYLPYPHPLPDGRQPGAGKKFEYRLPVAGIETAEKMRDKNSVSSNEMFAFGIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBV4</accession>
    <name>A0A194XBV4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_733488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072008.1">
        <property type="nucleotide sequence ID" value="XM_018219805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBV4"/>
    <dbReference type="STRING" id="149040.A0A194XBV4"/>
    <dbReference type="GeneID" id="28829531"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733488"/>
    <dbReference type="InParanoid" id="A0A194XBV4"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="29076" checksum="629FE5D56ABED2C0" modified="2016-10-05" version="1">MAPVTAPMNFLVRDSLYDDERPYLLIYEPPAGFPKQNIKLEKHTDLRIEDIRVCKDQPSLDKNGFQITKFSSKMSRADFDNEELVKTVYLKEVVDHVQAIFGAQKVQIFEYVLRKRHEQFPISTGEPYEFNQPTSIAHVDTTHSWTEEMVKRLNPATANQLLESRVLCVNVWKPLRGPVRDWPLALCDPLTVDTQDLHPGDLVYDDYVVENMQLHYDDNQNWYYISLVYLTQLFHFQKTKILKCHEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCE4</accession>
    <name>A0A194XCE4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_747774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072195.1">
        <property type="nucleotide sequence ID" value="XM_018221134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCE4"/>
    <dbReference type="GeneID" id="28830860"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_747774"/>
    <dbReference type="InParanoid" id="A0A194XCE4"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="23954" checksum="1AED7FC8864F07C5" modified="2016-10-05" version="1">MPPHHRKGPQLQALLDLFATYELQLPSRVVLPNSPCSAAIDGLRCYSAFTCCLCTSCLTRSKHALEVHVSKAHQQKLAQQVEGSSWRECTIQTFFAEKQHIRYFVVDDAKEAAGASDASIKSLDSGEANFFKLVDEDVAIAEADAKAEANIVHGFDSHRSAVILWLRRTGIEEHTRGLKKDEMHASFAVPKTAESEPELFLMLEIMDEIFTEAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE15</accession>
    <name>A0A194XE15_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_48210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072773.1">
        <property type="nucleotide sequence ID" value="XM_018207839.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XE15"/>
    <dbReference type="GeneID" id="28817565"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_48210"/>
    <dbReference type="InParanoid" id="A0A194XE15"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="194"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1309" mass="143758" checksum="4E120DA43769E98A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEL4</accession>
    <name>A0A194XEL4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_582436</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072985.1">
        <property type="nucleotide sequence ID" value="XM_018209169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEL4"/>
    <dbReference type="FunCoup" id="A0A194XEL4">
        <property type="interactions" value="667"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XEL4"/>
    <dbReference type="GeneID" id="28818895"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582436"/>
    <dbReference type="InParanoid" id="A0A194XEL4"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="243" mass="27142" checksum="89BB9F4A77EFA07E" modified="2016-10-05" version="1">MDISDILQDLNTRHLDRDPFAENGDDYGEDEQSGQADLQALTRAWVNERGAAELLPWPKDGLVERATNRIKQQIELVETMTGDMDPKTNFSLIIIQTEVERWKFLIRSYLRARIAKIDKHTLHYLSTPALMERLSKTEVAYATRYQQLLHGHYLSSFLGSFPANLQNLNDTAGGISMIGGPDEEAGVFVRGLGSREVGGEGSVAVRGRGRDGDGEIDVQRGEVVIARWSDVRDLVSKGEMELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEZ3</accession>
    <name>A0A194XEZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_780766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073115.1">
        <property type="nucleotide sequence ID" value="XM_018222414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEZ3"/>
    <dbReference type="GeneID" id="28832140"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780766"/>
    <dbReference type="InParanoid" id="A0A194XEZ3"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="26654" checksum="8B5F881C087CEE35" modified="2016-10-05" version="1">MDLSQLPDDFFVTLSQFTKTTYRDVYPVVDPTSPALSQQGKVVIITGTSQGLGRHGFAQAFAKAGVKALVLVARNADGLEAAAREVKAVNPKIQVLTQAMDIRSEDEVKKLFSRIESEFGMADVLVNNAASGKSALPVRDVDPNDFWYDFDVNVKGTLLMSQGFLKLVGKEKPATIINISSAGGIAVIPSTSSYSLSKLVQIQIQRFIAAENPNITAISMHPGTVLTPITKPQFEKFSKDTYALAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF25</accession>
    <name>A0A194XF25_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_732314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073123.1">
        <property type="nucleotide sequence ID" value="XM_018219668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF25"/>
    <dbReference type="GeneID" id="28829394"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732314"/>
    <dbReference type="InParanoid" id="A0A194XF25"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24777" checksum="E8332B75FE6932A7" modified="2016-10-05" version="1">MSFMSDTPLPLRPTPRRPCPRCPHRLSDLASHVEPAELSAEEEVKTIEGHATSESEEIPATTSEFETWRDLLEELKGKRVPACDDDQNNGKQPATDEAQTDPPIYNERKKDILVDMSLEHLDEKAEAADKDSSGVAAIKNKDVPIRKGILIRARTKSDGLQKKKSVRFHKGCKGDDSFEDESRGWSPVPCEYHVEMDKEPEGNEEGERKPVEEEEEENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFX2</accession>
    <name>A0A194XFX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_667746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073027.1">
        <property type="nucleotide sequence ID" value="XM_018212998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFX2"/>
    <dbReference type="GeneID" id="28822724"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667746"/>
    <dbReference type="InParanoid" id="A0A194XFX2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="237" mass="26381" checksum="380B915011E68106" modified="2016-10-05" version="1">MSKLPTHLKMLRRPRSPREAYEMWRKEGGGYQIGVRLNDASSKIITEFRLGISKAAGCPPVKVAQQNVVFLFAEVPASGLEFYEDTLATVAKHRSPFRVIFEDPFVSGQDKESPSVLALEIVGLEIHSVYDELWEHLGAVPRMRAQKSGKRRLKMNILSSAPSEKVKSGLLLAGAELRKANLSATAIGLCLRFVPVYAPRERFYRANTVLPDWQVIPFQGSKRISALEDGDQPDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGT7</accession>
    <name>A0A194XGT7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_488809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073699.1">
        <property type="nucleotide sequence ID" value="XM_018207876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGT7"/>
    <dbReference type="GeneID" id="28817602"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_488809"/>
    <dbReference type="InParanoid" id="A0A194XGT7"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="522" mass="58502" checksum="5FC8684F4FFCE04B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH10</accession>
    <name>A0A194XH10_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_695964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073781.1">
        <property type="nucleotide sequence ID" value="XM_018216795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH10"/>
    <dbReference type="GeneID" id="28826521"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695964"/>
    <dbReference type="InParanoid" id="A0A194XH10"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="37638" checksum="54787A1445BA5E79" modified="2016-10-05" version="1">MSPSSRRWSPPPEPEKPQVPYEKGHRFTACRVVAPPPFLGRYAEVPTGLFADFLSDARFPSEDFLRTTTLVDYCLSASSRPLPCESLKETATFEVLDELAVGDGLGRGGDSQVFTCIRHSDKEELVAKVYDPLYYPFADDEAEHDFALESAAYVQLDEKLGGSLIPKFYGSWAPDLPLKHQNRSVFFTLLENIRGTPLSVLDPDLYTQKDRLNVLALSMEADLKLRFEGVVHNDIAPRNIICSGKDLLAENLRLGIIDFNVAIVSPLLGVDAPCESESLPESPVEWFWGSRPVGMREWVPVEWKGHGWHRWLKERWGGSLKYKPVPKHFYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHD4</accession>
    <name>A0A194XHD4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_494779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073928.1">
        <property type="nucleotide sequence ID" value="XM_018207922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHD4"/>
    <dbReference type="GeneID" id="28817648"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_494779"/>
    <dbReference type="InParanoid" id="A0A194XHD4"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="20898" checksum="E4E24E1FB2C9C47E" modified="2016-10-05" version="1">MYCWFDALSLLKEQRSCLIHTELTDDNGNTPWDCFVFVHSVQPTHLGLKQPSNAEREAFEDLYKAHRNGRLQNEIEYLEIAFGEVINRQSKEAITTLSRLSEDMKKQRNLVAAETYRVISLQIRQNMWEAAIEAVRERFEALQAEMKSSPWDREVRVDNMRISHLKVVEKKAIMTGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHP5</accession>
    <name>A0A194XHP5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_457542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074011.1">
        <property type="nucleotide sequence ID" value="XM_018207653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHP5"/>
    <dbReference type="GeneID" id="28817379"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_457542"/>
    <dbReference type="InParanoid" id="A0A194XHP5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="20869" checksum="75303B826EBE3DCF" modified="2016-10-05" version="1">MHSLNHLLNCVRARLSTKETSIKPKDPETPAENILHNRKTSNNDSIKSDFAKMEEERIALARAQTTLDFYGHLKALDKVHLDMKPDPTLVDEFGRMFTYALLREAKDPKKVFQIERFVELHRRATEFWFKYGEKRRENCKQPSNLLPTTLSPLGVEGSRVCQHTLTCQQGTLSSSRLKTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIE8</accession>
    <name>A0A194XIE8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_642647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LovG"/>
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        <property type="entry name" value="ESTERASE ALNB"/>
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            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="26301" checksum="BF36D5221CD66077" modified="2016-10-05" version="1">MHFLCLHGIGTSNQVFEVQTAALRYELGDNHSYEFVEGTVPWQLAPEVSSMFNPKDSYHAYFDPESAPSAQQALDQLDDYVHTEGPFDGIIAFSQGAALAATYIIRKSKQSKPGNHNEMPIKCVVFLSSTALYDYELYFEKGQLRVLDADIDSELIQIPTVHIWGEQDNLRKDSERLSRLCAQATVFVHGGAHEVPGLGSNANVTGAVNAIRRGIREAQDLMSRGLDGRVEGNGVDAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ87</accession>
    <name>A0A194XJ87_MOLSC</name>
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        <submittedName>
            <fullName evidence="11">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_641751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
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            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
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    <comment type="subcellular location">
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            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268308" evidence="9">
        <location>
            <begin position="21"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="220"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="609"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="610"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="651" mass="71201" checksum="312011DEE2928E43" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJY9</accession>
    <name>A0A194XJY9_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207560.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJY9"/>
    <dbReference type="GeneID" id="28817286"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_443229"/>
    <dbReference type="InParanoid" id="A0A194XJY9"/>
    <dbReference type="OrthoDB" id="5370537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="217"/>
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        </location>
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        </location>
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        <location>
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        </location>
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            <end position="2176"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1574"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1803"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2143"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2153"/>
            <end position="2166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2401" mass="263393" checksum="5A79A75A92F4B3F4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK74</accession>
    <name>A0A194XK74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative rhamnose biosynthetic enzyme 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_473556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074547.1">
        <property type="nucleotide sequence ID" value="XM_018207788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK74"/>
    <dbReference type="STRING" id="149040.A0A194XK74"/>
    <dbReference type="GeneID" id="28817514"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_473556"/>
    <dbReference type="InParanoid" id="A0A194XK74"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="49"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="431" mass="48455" checksum="8AF7EBB9F6F42BFB" modified="2016-10-05" version="1">MSGHTNGHAASASNPNTLKFFEDFGIWKEAPILTGSTKFEPLPDVKNIMITGGAGFIWSACWLVRHLTLTYPNAYNIVSFDKLDYCSSLNNTRALNDKRNFTFYHGDITNPSEVMDCLTRHNIDTIFHFAAQSHVDLSFGNSYAFTHTNVYGTHVLLESAKKHGIKKFIHISTDEVYGEVRDDADDLLETSILAPTNPYAASKAAAEMLVHSYQKSFKLPVIIVRSNNVYGPHQYPEKIIPKFSLLLHRGQPVVLHGDGTPTRRYLFAGDAADAFDTILHKGQMDQIYNVGSYDEISNLTLCSKLLTYLDIPHSTQEELHKWVKHTIDRPFNDHRYAVDGTKLRQLGWEQKTSFSAGMAITVDWYKRFGEKWWGDITKVLTPFPTVAGTDVIASEEPVENINDDMLVDSDDKMTLAKKRKIDGSTAQAVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKH4</accession>
    <name>A0A194XKH4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_610888</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074964.1">
        <property type="nucleotide sequence ID" value="XM_018210563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKH4"/>
    <dbReference type="STRING" id="149040.A0A194XKH4"/>
    <dbReference type="GeneID" id="28820289"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_610888"/>
    <dbReference type="InParanoid" id="A0A194XKH4"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000009">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="471" mass="51732" checksum="2E9A081426FCB053" modified="2016-10-05" version="1">MHLRSYSRIALRHWLNYSGLIQRQSPRTARCFHATAKALVIKPFLLADIGEGIRECEIIQWFVEPEARVEEWDKLCEVQSDKASVEITSRFAGVIKKLHYEAGEMAKVGKPLVDIDIQGEIKQEDLAAVTEGEESQIQAEDTEARVPEAEPAPETPAMEEEAPSPPKGKHASLATPAVRHLTKELDVNIEDVQGTGRDGRVLKEDVYQYAKHRDTTPSTPSKQPTTPGQQTETITPLSTTQHQMFKTMTKSLSIPHFLYAQELDLITLSSLRHRLNKSLSLTPQNGISKLSFLPFIIKAVSMTLAQYPILNARVDTDPKTTKPTLVYRSQHNIGIAMDTPSGLLVPVIKDAASLSILDIAAKISRLQSLASESRLSSADLSSGTITVSNIGSIGGTYVSPVIVEREVAILGIGKVRSVPAFNEEGTVVRKEVCNFSWSADHRVIDGATMARAAEMVRGFVEGVEGMGIHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLS4</accession>
    <name>A0A194XLS4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_778661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075389.1">
        <property type="nucleotide sequence ID" value="XM_018222226.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLS4"/>
    <dbReference type="GeneID" id="28831952"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778661"/>
    <dbReference type="InParanoid" id="A0A194XLS4"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1933"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1489"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1491"/>
            <end position="1502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2125" mass="235871" checksum="8F70BABAF7F1F379" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMI8</accession>
    <name>A0A194XMI8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_435667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075825.1">
        <property type="nucleotide sequence ID" value="XM_018207507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMI8"/>
    <dbReference type="GeneID" id="28817233"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_435667"/>
    <dbReference type="InParanoid" id="A0A194XMI8"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="33264" checksum="D1B680A0C1573ADF" modified="2016-10-05" version="1">MSKPEFTLRTDVYPAIEPELFKGSLNGKVAFVTGSGRGIGREIVLALARSGAAVAISGRTKSQVEETTQAVLSSASGVKAIGVVGDVCSRTDQERMVKEVTESLGPIDILICNAGTNTFMPFHMTDPDEWWKQMEIMVKSPTELTRMILPMMQKRNSGTIIYTSSRAAGADLPWAAGYSCAKTAITRFAGILQNELNILQKDTFGHDTNGISVFSIHPGEVKTKLHETAFPQKTKDEAPYVIEHMAKMAKMHPDFKAELAAWTCVYLSAGNGAGLEGRLVDCTRDIEEVKKHVTATPRPRITNACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMQ2</accession>
    <name>A0A194XMQ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_681896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075724.1">
        <property type="nucleotide sequence ID" value="XM_018214396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMQ2"/>
    <dbReference type="GeneID" id="28824122"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681896"/>
    <dbReference type="InParanoid" id="A0A194XMQ2"/>
    <dbReference type="OrthoDB" id="120613at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268411" description="Chitin-binding type-4 domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="9">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="28619" checksum="F3AFE88401EA068D" modified="2016-10-05" version="1">MQYTSTILATSAALITSVSAHGFLTSPQPRMPGSAMEAACGTQVYDNQASDNYGNIQGELQVAASQTDYNAAECDIWLCKGYKYADNTDNVQSWTAGQVVDMTFDIRAPHTGYANVSIVNTATNTIIGDMLLYYSDFADNAKTIPANETSFSITVPNDLGDTCSTAGACVLQHYWNAESIDQTYESCIDFTVGGSGSSSVSSSSPVVASSTSASSSVLASTSAQVVSSTPAAVVTSSSTRVSPSTLQTVVKSSSVVASPTSSAAVPTETPDDDDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNW0</accession>
    <name>A0A194XNW0_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ21863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNW0"/>
    <dbReference type="GeneID" id="28831922"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778231"/>
    <dbReference type="InParanoid" id="A0A194XNW0"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="643"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="934" mass="102835" checksum="839824DF3D2D9989" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP36</accession>
    <name>A0A194XP36_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_391107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076365.1">
        <property type="nucleotide sequence ID" value="XM_018207191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28816917"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_391107"/>
    <dbReference type="InParanoid" id="A0A194XP36"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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            <end position="11"/>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22010.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1281" mass="140166" checksum="C85D8B82AC90F62D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP90</accession>
    <name>A0A194XP90_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_729486</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219385.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28829111"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729486"/>
    <dbReference type="InParanoid" id="A0A194XP90"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13876" checksum="935C9D99D1BFF403" modified="2016-10-05" version="1">MGSKPVTRWPGADQQDPEPDDSGVSLRSPTPPESGNGDNSTIRICPNWMFPVALVLMVAIVAYFVLRSVKPESGTNVSSTQPQTSYLPRWAGNSRFRTTVKSPTQQISHVPTCTDNLPFGCVPSTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPA3</accession>
    <name>A0A194XPA3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="1">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="24825" checksum="35D1B74E15CADCB9" modified="2016-10-05" version="1">MNSSMMDTNMNSSMGNNMSPNMDTNMNMDTNMSMNNTMEPKMGMDAQSPIQKYQSLLSTNKFVFLVFFRGHWCPFCMGYLRTLTALSPSITAAGGAVLIVTAEPSSFLPSTREKTSYTGDAISDTKNELATHLRAKGLLDVAITEKKGYEHGMAQPAILVQSKEGEVLEKWAIVPSAMNLGGAKDRPELEQVWENVQAKMAGKMKVHSSYKKIGALSFLWKKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ88</accession>
    <name>A0A194XQ88_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_714176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_714176"/>
    <dbReference type="InParanoid" id="A0A194XQ88"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ22358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="24290" checksum="3E883E02826C0F34" modified="2016-10-05" version="1">MALASGAEQGKARGKRQQTEMIWHRADAAELGIPPSTGWACCLVTIAFWHWHLIHSVRIRPYSLLVGSTLTSPKRAFQEVRPKVPARHIEQSHIAIAIDTWTFFRNMGKANSTNATYGGPIFRHHRSRATLRLPACVERGNAGERQNGKERQVMQFQIRPPEVIEGYAAACSRRLTWAKLARASVEYAVPVRLEERRLACGSDHSRRTGLLYPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQP4</accession>
    <name>A0A194XQP4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_728652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219284.1"/>
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    <dbReference type="GeneID" id="28829010"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728652"/>
    <dbReference type="InParanoid" id="A0A194XQP4"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268500" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="654" mass="74463" checksum="E73495D0619CACFC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQT5</accession>
    <name>A0A194XQT5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_728760</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076995.1">
        <property type="nucleotide sequence ID" value="XM_018219303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQT5"/>
    <dbReference type="GeneID" id="28829029"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728760"/>
    <dbReference type="InParanoid" id="A0A194XQT5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268546" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="9681" checksum="7A08C2D88CAFE1CF" modified="2016-10-05" version="1">MQFHLFPLLLLAASPLAASFRCSGALAGKCCNPSSLFSSGTISFGIYSACSPAKVQANTNPALKQYTCKLNTPGHTQGNCCYSLGSTAVICGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQW1</accession>
    <name>A0A194XQW1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_664467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077025.1">
        <property type="nucleotide sequence ID" value="XM_018212772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQW1"/>
    <dbReference type="GeneID" id="28822498"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664467"/>
    <dbReference type="InParanoid" id="A0A194XQW1"/>
    <dbReference type="OrthoDB" id="5234213at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="129" mass="13404" checksum="4FA0B755B83CC245" modified="2016-10-05" version="1">MPPQGKKTLRESALETNKNNPSQLGDPISLKSETADSSPTNQDRGASSSSQSSSSVKENLKSTAPAPTEGDTDGKGKGGHQTLRQKAMQKLEENPSQLGDPVSLKAETADSRPTDQDKGAAGKGGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRC9</accession>
    <name>A0A194XRC9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_728731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076964.1">
        <property type="nucleotide sequence ID" value="XM_018219294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRC9"/>
    <dbReference type="GeneID" id="28829020"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728731"/>
    <dbReference type="InParanoid" id="A0A194XRC9"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="18878" checksum="C1CA3AC7F3B76DFF" modified="2016-10-05" version="1">MSSSNIFRNVQRDESPDFTEPNAMVTLIAFDNGNEVRFTVHKANVWFYSPILNAALTGLFVEGQTQTYKFSEDFHPQTIKLLCQWLYKQELSIKQLKKDWANVKDPLYVMEAYKKEDMALAELWVLADKLLMPQLKNKVVDYIRDIALEYTALPLNTICQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRL5</accession>
    <name>A0A194XRL5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_161104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077285.1">
        <property type="nucleotide sequence ID" value="XM_018205504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRL5"/>
    <dbReference type="STRING" id="149040.A0A194XRL5"/>
    <dbReference type="GeneID" id="28815230"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_161104"/>
    <dbReference type="InParanoid" id="A0A194XRL5"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="458"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="596" mass="62781" checksum="4616C7C9EE905951" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRQ1</accession>
    <name>A0A194XRQ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_680548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076762.1">
        <property type="nucleotide sequence ID" value="XM_018214098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRQ1"/>
    <dbReference type="STRING" id="149040.A0A194XRQ1"/>
    <dbReference type="GeneID" id="28823824"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680548"/>
    <dbReference type="InParanoid" id="A0A194XRQ1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="40"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="206" mass="23206" checksum="AE993EED7A229B06" modified="2016-10-05" version="1">MSFYNFPGFSAPDTSFHPLFRLLDQFDQYQDNTGRRHHRSQMKTFNPKFDVKEVDDSYELHGELPGVEQKDIEIEFSDDHTLSIKGRTERSYQSGTPPAGFVEGPTASGAITESGEEHKDHKAYVEDEEAGAKDANTEVAKKDSEQPKEPQAKYWVSERSVGEFSRSFSFPVRVDPDAVKASMKNGILSIVVPKAKQQSSRKITIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRU8</accession>
    <name>A0A194XRU8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_680885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077129.1">
        <property type="nucleotide sequence ID" value="XM_018214160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRU8"/>
    <dbReference type="GeneID" id="28823886"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680885"/>
    <dbReference type="InParanoid" id="A0A194XRU8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="56" mass="6539" checksum="2505CDBAB1D1CD85" modified="2016-10-05" version="1">MRALPNDVEESNCVLNIQRLSLGTLKHFKFDYMSQDVRDHCIKATCLRLSLNFQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSA9</accession>
    <name>A0A194XSA9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_679898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077438.1">
        <property type="nucleotide sequence ID" value="XM_018213963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSA9"/>
    <dbReference type="FunCoup" id="A0A194XSA9">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSA9"/>
    <dbReference type="GeneID" id="28823689"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679898"/>
    <dbReference type="InParanoid" id="A0A194XSA9"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000006">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="27778" checksum="EF6169D6F2655531" modified="2016-10-05" version="1">MLSTARSKGLERAIASAPTAPIPEFLLPGFPVRSSRSFSASTCRTSQIGRAPLSIPPEVNFNILPPPVRKNGRASPLATRPTVEIEGPLGKMSMTIAPFVKIDYDTAQRKAYVSVEDREFKKQREMWGTTRAYLHNHILGVSEGHTAILRLVGVGYRATVENTATTVEPEFEGQKFVVLKVGYSHPIEMPIPQGVKASTPQPTRILLEGCEKEVLLQFAAKIRMWRKPEPYKGKGIFVNGETIKLKAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTG6</accession>
    <name>A0A194XTG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_703994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077965.1">
        <property type="nucleotide sequence ID" value="XM_018217353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTG6"/>
    <dbReference type="GeneID" id="28827079"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703994"/>
    <dbReference type="InParanoid" id="A0A194XTG6"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="112"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="329" mass="37019" checksum="05414A25B820540F" modified="2016-10-05" version="1">MDSASVKVPPMKDLTIDNITENTIVINSQSSDQRLTYVMERLVTHLHDFARETRLSTDEWMAALNFLVKVGQISSDVRHEFILLSDILGLSLLVDAIDHPKPPASTEGSVLGPFHTHEAEDMKHGDSMSHDPQGEPCLVVCAIKDVKGNPIEGVKIDIWETDSTGHYDVQHAERDGPDGRCVMRSDKDGVFWFNAIVPVPYPIPHDGPVGQLLKLLKRHPWRPAHMHFMFEKPGWDHLITALYIRNDPYETSDAVFGVKQSLIVDFTSADAEIAKKYGVKEGTKFLKHDFVLVDEKETERLRDENALKALKALGRKIKLLNHLPVPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTM3</accession>
    <name>A0A194XTM3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_180988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077749.1">
        <property type="nucleotide sequence ID" value="XM_018205610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTM3"/>
    <dbReference type="STRING" id="149040.A0A194XTM3"/>
    <dbReference type="GeneID" id="28815336"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_180988"/>
    <dbReference type="InParanoid" id="A0A194XTM3"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116189" checksum="4322BD3B3FB9EFB5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUK5</accession>
    <name>A0A194XUK5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sec20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_776199</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078355.1">
        <property type="nucleotide sequence ID" value="XM_018222021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUK5"/>
    <dbReference type="STRING" id="149040.A0A194XUK5"/>
    <dbReference type="GeneID" id="28831747"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776199"/>
    <dbReference type="InParanoid" id="A0A194XUK5"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="167"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ24000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46240" checksum="68725B3D39BA2B0E" modified="2016-10-05" version="1">MSFEAVSDQLKILKEVNAQLKDLIDRLANINFQPGSVPLDEGDENVATELTSEIQQTIKDQDEDFELLLEEVHDLNSGMDNREELLSNVTRAIAELKLYQSAFRKAQITAKRKLEAAQRAERDLLLQSYIEPPRTNTSSPAPGPVPSRRRNQQTATLTEEEKTVNAASDVTRALRRTHDMMAAELARSQFAHETLTESTAALAQLSESYSTLDTLLSNSRNLLGTLLRSQKSDTWYLETAFYILMATIAWLVWRRLLYGPTWWLVWFPMKMFIKGWIGVFTAMGLVGGSKPESGVNPSLTPVMGHHTVAHSSGTRGPKPSLGPPGVHRVNVGGGGRGAPMQGSNNPQASKQETSGDSMSEKVGRIIDESRESPLGETEEGGDSAPKGEAEIQRNPKKRMWEEEREAGKDAQRKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUW2</accession>
    <name>A0A194XUW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_713942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077852.1">
        <property type="nucleotide sequence ID" value="XM_018218091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUW2"/>
    <dbReference type="GeneID" id="28827817"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713942"/>
    <dbReference type="InParanoid" id="A0A194XUW2"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="359" mass="40273" checksum="48BFBF2C86BC669B" modified="2016-10-05" version="1">MSGLADNNNLPRNQDVGPVLMAVTGIFAGLVLITTSCRVYVRIMSRVFGWDDAMILVTVAFALARLAVEIKQSQHGNGKHRVYLSTYDYMMINMWGWYAQVFLFAAVACLKVSIGFLILRIKDTKTFKILVYTLMAGVCFTNFGVVIILLAECKPAGFWRGSAAKCWPDKIRIYSIYATIAFSVTTDLFLSILPLFIVWRVRIPLRTKISVCCLMSLGLLATGFGIARAASLSIMTTDLSWMYCIAALWSNLELFLGIVCANLAIARSTYSYIFGRKETPQNDSYHSPSSPVPSSHSRFTNRKPSRDEFETRKTAEESRFRAPSESRSARSDIPLVIQKTAEFEISFEEEEMKIDRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV13</accession>
    <name>A0A194XV13_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_572219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078403.1">
        <property type="nucleotide sequence ID" value="XM_018208632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV13"/>
    <dbReference type="STRING" id="149040.A0A194XV13"/>
    <dbReference type="GeneID" id="28818358"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572219"/>
    <dbReference type="InParanoid" id="A0A194XV13"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="364"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="607"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ24048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="714" mass="80190" checksum="7F303096F6310BCD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWB4</accession>
    <name>A0A194XWB4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="11">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_634670</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="11"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078883.1">
        <property type="nucleotide sequence ID" value="XM_018211402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWB4"/>
    <dbReference type="STRING" id="149040.A0A194XWB4"/>
    <dbReference type="GeneID" id="28821128"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634670"/>
    <dbReference type="InParanoid" id="A0A194XWB4"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000027">
        <property type="entry name" value="Probable exopolygalacturonase X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268754" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ24528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="49727" checksum="BB8E406A997E3427" modified="2016-10-05" version="1">MRFQLTSLLALATVSIASPTWQAFEDWAKGAGGKSAPDHTSPRPSISCHPKSPHVPPPSPPPRNKVCYVQSHNDGVTDDSTYILSALHSCNNGGHVVFREGIKYTIGTALDLTFLEHIDIDIQSYIQFTNDTTYWQANSFRFIFQNVTSFFKLGGNDVNIYGGGTIDGNGQVWYDLYASNIYTLRPVLIGIDGLHNSILSNLVLRYSPEYYHFVANASNVVFDNINIAGASKSVNVAKNTDGWDTYRSTDITIQNSVINNGDDCVSFKPNSTNMLVQNLWCNGSHGISVGSLGQYVGEYDIVENIYVFNASMHNTTDGARIKVWPNTPSALSGDLQGGGGSGKVNNITYDTMLIDKVDYAIEVDQCYGQSNLTLCLEYPSPLTITDIVFKNFNGKTTSKYQPEIGTFACSSSAVCNNIVASNINVVSPNGTDLAYCLNVNETALDVTCSTLYKGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXD5</accession>
    <name>A0A194XXD5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_22901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <end position="242"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="296" mass="34690" checksum="A3FBD21926D041B8" modified="2016-10-05" version="1">MPLGQQSCPRRYRCSVLALMYRSAVHLSYYISSVFLPNFTVCRSISTNSDLWVLFTMASTDPRYGSLNSAAPEFYPPLPPHPQATWRSDSDHVAHRTVLDRFEEQWRSSQGRVVPIENINSPPLDYARTHSPILPSANAPFYVPRQYESPVYQHRDRQDRITSPGPEPVYREQNYVQVNQAPRPPVIRPSVPGYQPWQRIPDMERSSDYSRPPFNSPQAYQDRVAPRPATVPPQQYRQQLQPRHTRPESRSRRHNPYTESRRRRRSTSSQPRHPQKRRYTPPQHNQRQFPSRPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B272</accession>
    <name>A0A132B272_MOLSC</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="28826273"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692473"/>
    <dbReference type="InParanoid" id="A0A132B272"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="66" mass="7477" checksum="FA1027F90596BFFC" modified="2016-05-11" version="1">MIQLVLEHNNTSLNFNISNIFIPTIPRFNPDNANMQTRVAALEALFIYRANWEDSVEAAKSRNNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2X7</accession>
    <name>A0A132B2X7_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_405127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B2X7"/>
    <dbReference type="GeneID" id="28817016"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_405127"/>
    <dbReference type="InParanoid" id="A0A132B2X7"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005680">
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    <dbReference type="GO" id="GO:0005721">
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="620" mass="70220" checksum="16505ADFC856DA2B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3A9</accession>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="50" mass="5587" checksum="3619A38EB42ADCFD" modified="2016-05-11" version="1" fragment="single">AAPETSNQGPTYPTLRANPFPEVTDLFCRLPLSTLFYQLEAVHLGDLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3N7</accession>
    <name>A0A132B3N7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216506.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A132B3N7"/>
    <dbReference type="GeneID" id="28826232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692280"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287818" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="31"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="334" mass="36395" checksum="7BF04B26F35D4275" modified="2016-05-11" version="1">MKSLSVAAAFVASVQAGLRFGCSSLTIQRLDPVVQPGSDPSSHLHHIVGGNQFNATMTGDVGARGSCTTCQMAEDFSNYWTAVMYFKHPTNGSYHRVPVVNNAALASGTTGGITVYYTPYDLSRDNLKQQPITVFKPGFRMTVGSPTTNATQAAKHIGLSYNCLTTLINRGPEMRDFPTKPCPAGIFVTHHFPACWDGKNLDSPDHQSHMYNTITLDGFTNAPPCPSSHPVRVPQVTYETVWDTTKFSSLWKSGDPNPFVWSFEGTSGYGTHADYMFGWKGDALQRAMNKSECFYDGCGSITKQDMSVANKCTVKDMVGENIDGWVSHLPGMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3U7</accession>
    <name>A0A132B3U7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_661190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061356.1">
        <property type="nucleotide sequence ID" value="XM_018212590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3U7"/>
    <dbReference type="STRING" id="149040.A0A132B3U7"/>
    <dbReference type="GeneID" id="28822316"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661190"/>
    <dbReference type="InParanoid" id="A0A132B3U7"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="310" mass="34572" checksum="E13832C0997B0822" modified="2016-05-11" version="1">MSNNTNPTVAGGKKIVFTGGSGKAGRHVIPYLLSKGHKVLNLDLVPFPDTSVDVYTMKTDLTDSGQVFNALISHFNMTGYSDGPIPAAPDVVIHFAAYARNMLVPDSECFQANVRSTYNVVEAACKLGVKKIIIASSETTYGVCFAQGDADYHSFPLEEDYDVDPEDSYALSKICGEKTARTFSRRFKNDIYALRIGNVIEPHEYERDFPSYISNPSSRKRNAWSYIDARDLGQICDLAIKKSGLGFQVFNATNDTITVKGTTREFLERECPGTKVTREMGEFEAPLSNRKVREVLGYQDVHDWRKYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B513</accession>
    <name>A0A132B513_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_789597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061855.1">
        <property type="nucleotide sequence ID" value="XM_018223275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B513"/>
    <dbReference type="STRING" id="149040.A0A132B513"/>
    <dbReference type="GeneID" id="28833001"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789597"/>
    <dbReference type="InParanoid" id="A0A132B513"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="629" mass="69390" checksum="7B9523A5E4F98BF4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B565</accession>
    <name>A0A132B565_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061911.1">
        <property type="nucleotide sequence ID" value="XM_018220873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B565"/>
    <dbReference type="GeneID" id="28830599"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742784"/>
    <dbReference type="InParanoid" id="A0A132B565"/>
    <dbReference type="OrthoDB" id="3555378at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="35304" checksum="39CA0F4998CD880E" modified="2016-05-11" version="1">MADSSDTTPSPLATGISPIFSTAGENNTSTEPGIAAASSSTNARPIQSTNGETTALAGAETLTSSALIDFATRSAATEATALTEFHLFPKLAPELREIILQVSSDTYKFAIPTGHNGERMIPIKTDIDYTKLGRAALSFSIPPNAEAIDSRCCDVYDLSLSVTSREARAAYLSSFTRCIHLKQGFVRFAANTLVYIPDMDYIVYGPYFEHMLLETAHTTKFLAAVDHLVLPYSVMMVYLAIGPHHRSERFTLAWMDFLMTFKSLTGHPTSREGIWQHMNAKTRLLLTERYEATSVRRLKDHKEKHVSLEAFPKLLCRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5D9</accession>
    <name>A0A132B5D9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_555549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061980.1">
        <property type="nucleotide sequence ID" value="XM_018208363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5D9"/>
    <dbReference type="STRING" id="149040.A0A132B5D9"/>
    <dbReference type="GeneID" id="28818089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_555549"/>
    <dbReference type="InParanoid" id="A0A132B5D9"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7523" checksum="3EBF7D526B40CE22" modified="2016-05-11" version="1" fragment="single">YDVLGVPKDARIDEIRVAHRELVLKCHPDKLQDQSSKVLKQKEFDEIQKAYEILSDPVRRAEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5K5</accession>
    <name>A0A132B5K5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_691447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062051.1">
        <property type="nucleotide sequence ID" value="XM_018216325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5K5"/>
    <dbReference type="GeneID" id="28826051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691447"/>
    <dbReference type="InParanoid" id="A0A132B5K5"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="326" mass="35288" checksum="10C586B89318AED6" modified="2016-05-11" version="1">MAETMQAIIIPSFGGPDVLTYSTVPKPSPVQGEVLVHVHAFGVNHAEMHMRRGEWDEWNPISGLECVGTVAACPDGSIPESTKVAAVMGGMGRSRPGGYGEFVNVPIANVVPLETNLPWEELAALPEVYSTAWSCIHTVLDVKKGETLLIRGATSTIGQASLNLAVNAGAKVTATTRRTERFEMLKKMGAVDAVLEKSDLGTTFPGKRFDKVLNLIGNRVLLESISLTKAGGRMLQAGWLGGLAPVKDFNPMVEMESGVHFSLYHSKVLGTEDFPMSQIPLQEIVKKIENGEWDAKPTYVFEYTDIHKAHALLDSHNAGGKIVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B650</accession>
    <name>A0A132B650_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_702279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062240.1">
        <property type="nucleotide sequence ID" value="XM_018217245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B650"/>
    <dbReference type="STRING" id="149040.A0A132B650"/>
    <dbReference type="GeneID" id="28826971"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702279"/>
    <dbReference type="InParanoid" id="A0A132B650"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="586" mass="64694" checksum="C7734B0063309D3A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Z8</accession>
    <name>A0A132B8Z8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_325089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063078.1">
        <property type="nucleotide sequence ID" value="XM_018206737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8Z8"/>
    <dbReference type="GeneID" id="28816463"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_325089"/>
    <dbReference type="InParanoid" id="A0A132B8Z8"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="94484" checksum="563FD17EC640BDD6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B984</accession>
    <name>A0A132B984_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_788921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062914.1">
        <property type="nucleotide sequence ID" value="XM_018223209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B984"/>
    <dbReference type="GeneID" id="28832935"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788921"/>
    <dbReference type="InParanoid" id="A0A132B984"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27086" checksum="6EBCA59B5D72BE18" modified="2016-05-11" version="1">MSNPTVVIIPGAWQPAEAFEPFGEHLRDVGYPTEVISLKSVGGTETPLAGLKEDADAVSEVLTKLADEARDIVLLCHSYGGVIGSCAIEGLDFATRRNAGKAGGVILTVYMSAFMLPKGMNVLDGLGGKPMPWMKIEEDKCFAVASELPQIALNDMPAEKAKAYSAQLTHTSVSAFATPSTFEPWANAIPCTYIFCEIDNALPLPVQQQMASQLGPNATTFSLKAGHCPFLSMPEQLRDVIVKASEVGLSRKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9L8</accession>
    <name>A0A132B9L8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_319997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063455.1">
        <property type="nucleotide sequence ID" value="XM_018206703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9L8"/>
    <dbReference type="STRING" id="149040.A0A132B9L8"/>
    <dbReference type="GeneID" id="28816429"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_319997"/>
    <dbReference type="InParanoid" id="A0A132B9L8"/>
    <dbReference type="OrthoDB" id="5213630at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="310" mass="34706" checksum="DC9EACCA6A619C55" modified="2016-05-11" version="1">MENPVIQQLRQELQVECLAREKAEQTLDVKTSELNTIRTNWTTTARELDQLRVSTAPKSLILTDDHLRDKLALLRYQTRNLAILYFDGDLTQAAKANPTSLLDPYLKPTTPGTNTYEILLNSSNAAQKVVRAYIWRVLVGEVFGQFLWAGDIGQHMAVIGSLLRPSGDPPDPVAERKFALWSNDTTQILLDALGLRIEAEGHDVRYATPRVKTLVSLILETISPFLREKEGQLQTTLLEIVDAAIKLDKEMCQQITRLTWVFGDMEAGTVVLAPGLKRRGRSDGKEFETEKVVLIKEISLEPGLKMGKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAC0</accession>
    <name>A0A132BAC0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_741641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063159.1">
        <property type="nucleotide sequence ID" value="XM_018220734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAC0"/>
    <dbReference type="GeneID" id="28830460"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741641"/>
    <dbReference type="InParanoid" id="A0A132BAC0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="20287" checksum="4C29FE0CEC91564F" modified="2016-05-11" version="1">MPNSFFTQLGALAVIGYIVLRYLSPTRRTLSLGPNQLSILANVKDLPPPDVLESQHWLKHKDLHGPISSVTVLGMTLVLIHDKKVAHGLLEENASETSGRLSMVFTNQMCGFEYIVLCQGYNSTFRHHRKLLREFGIKVSAAQFRDIQEVEVNRQLVHALNEPGKLLEHYRTQVRIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBU8</accession>
    <name>A0A132BBU8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phytochrome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_760652</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064257.1">
        <property type="nucleotide sequence ID" value="XM_018221511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBU8"/>
    <dbReference type="GeneID" id="28831237"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760652"/>
    <dbReference type="InParanoid" id="A0A132BBU8"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
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    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
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    <dbReference type="InterPro" id="IPR035965">
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        <property type="entry name" value="PAS_2"/>
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    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="248"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="620"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="968"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="871"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ09902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1127" mass="125720" checksum="E398B76687603963" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDF0</accession>
    <name>A0A132BDF0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="334" mass="37601" checksum="087AC9AC036CEF33" modified="2016-05-11" version="1">MDSCLDHFALFPLFPVEIRLNIWNRSFPEPRIIDLKLINSKGESLNQKNRTIDGPWHWASTSSFSLPLLQVNHEARRLMLQSYKPTNICQQNGAILYIDFERDTVYRACYQCDPLFQFDLTHDTVVSNASSWTSNVTNLALHLTVFKGRDASGQTIVCPSLDTFSLPSARQGPLRNLHTVCMHFPALRKLWIVIDGRDDQFVGKDEIVDPSPQHGDWFLHIKMVDALGAIELVVEDSRNQQPDSSLPQINLGLLTNGQDNELATRRWYYDFAGRKFEQPTANSGRFFRAPGDSDSESSGLSEDDGDFIATVLDSDGRAPGTFHCIPGHASDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDZ3</accession>
    <name>A0A132BDZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_675409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDZ3"/>
    <dbReference type="GeneID" id="28823231"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675409"/>
    <dbReference type="InParanoid" id="A0A132BDZ3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="169" mass="18803" checksum="CF898F03D2BBB7D5" modified="2016-05-11" version="1">MIGPDLDMTFQTQLQNFDGFSNNQNTLPTELWEQFGQSGRTQTLPTIGCFDNNFLDKLFQTPTIPSSADESSRPTSNAQSPTRTTKGVRTDNEILGHTAMLSSMPQHQRAIEASPVHSGQMSSELASPHTKSVSSEDIKLYTTQILDLHRRSTRDADEYMATRHSSPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEI5</accession>
    <name>A0A132BEI5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_787451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064774.1">
        <property type="nucleotide sequence ID" value="XM_018223076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEI5"/>
    <dbReference type="STRING" id="149040.A0A132BEI5"/>
    <dbReference type="GeneID" id="28832802"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787451"/>
    <dbReference type="InParanoid" id="A0A132BEI5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="57747" checksum="29E54CB3D94C0D51" modified="2016-05-11" version="1">MEFPLSSSYAALFSIAGLALVLLFSKIRGRKSLPYPPGPPGEFLIGHLRVVPFEDSHTAYLNWGKEYNSDVLYFNTLRQPIVVLNSQKAAKDLLDNRGSIYSDRPKFELLKLLGWGMTLTWLRWGPKMQQHRKILQTPFTKSKISQYQNLQLEQTHHSLRGILENPLHWELELKRLAIAITAEIGYGVKVDSVYHPWVKLSDDAGYATSHAGAPGGSLVDRFPPGWLPGLHSVKYAHDNKFAITNIHDIPYNGAVKEMEKGLSGDSFIHNLLYKYRMNEKAGLRNEFTLADIKGSAGAIIIAGSKTTMTTLVVFVLMMMCNPEIQRKAQAEIDAAIGSERLPGFDDLERLTYLNYIKQEVFRIAPLSPLGIPHVNLTDDTYNGMFIPKGSIIYQNVYAMHRDESIYSNPYEFDPDRYIPKDQGRRGEPFPNGNFGWGRRVCPGQFLANNTLSLVMATFVSTLNIDWPMGPSGKPTPFTPEWSKIGLYHPKKFQCSIEPRRDNVRELALKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BER9</accession>
    <name>A0A132BER9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_596816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064532.1">
        <property type="nucleotide sequence ID" value="XM_018209943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28819669"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596816"/>
    <dbReference type="InParanoid" id="A0A132BER9"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1545" mass="171272" checksum="085D98C215552C92" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSP9</accession>
    <name>A0A194WSP9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TBCC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_596050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064997.1">
        <property type="nucleotide sequence ID" value="XM_018209894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSP9"/>
    <dbReference type="STRING" id="149040.A0A194WSP9"/>
    <dbReference type="GeneID" id="28819620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596050"/>
    <dbReference type="InParanoid" id="A0A194WSP9"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000017">
        <property type="entry name" value="Similar to tubulin-specific chaperone c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="194"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="43063" checksum="0A96727CBD99D325" modified="2016-10-05" version="1">MENPVTNYHQSAISDSQIKDRFYRYFQQECTELQEQIVRLENYSFVGGEKQDAIDHVLSGISRLANDVSDSSAFVPAYDQRIYAQASLPKAIKALEEKLQEARAKFAPRSRFQFKNKNTSAISINDAAELAAQQRLNASGLRPGFASSTESSMATTPANLMTPPGERDSKDTLGDLPSFPKNYNEEMSRGMPGPIRKPSFSQATNVNITGHTGLHIILPSSASRATASGSLTKLSRCIVDMSVPTATKAPFAGLALNNIKNSLIIAGHVAGAAHITGVENSIIVVASRQVRMHECKNVDIYLHCASRPIIEDCSNVRFSPIPENYMTASEEPVQNHWDQVDDFKWLKAEHSPNWSILPEEKRINSDTWTKDVPGGPGVGLEDIFKTVGLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WST4</accession>
    <name>A0A194WST4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_700622</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065037.1">
        <property type="nucleotide sequence ID" value="XM_018217137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WST4"/>
    <dbReference type="FunCoup" id="A0A194WST4">
        <property type="interactions" value="1350"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WST4"/>
    <dbReference type="GeneID" id="28826863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700622"/>
    <dbReference type="InParanoid" id="A0A194WST4"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098562">
        <property type="term" value="C:cytoplasmic side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="428"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KUJ10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="532" mass="59368" checksum="EF9BBC822DE84F07" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTI3</accession>
    <name>A0A194WTI3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">Tricorn protease N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_710359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217824.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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        <property type="entry name" value="WD40"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66094" checksum="ADD07F7D8D33E355" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTQ8</accession>
    <name>A0A194WTQ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_674674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065698.1">
        <property type="nucleotide sequence ID" value="XM_018213455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTQ8"/>
    <dbReference type="FunCoup" id="A0A194WTQ8">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WTQ8"/>
    <dbReference type="GeneID" id="28823181"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674674"/>
    <dbReference type="InParanoid" id="A0A194WTQ8"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ11343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="595" mass="67081" checksum="78D62858166E3E20" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTZ4</accession>
    <name>A0A194WTZ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065437.1">
        <property type="nucleotide sequence ID" value="XM_018215830.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28825556"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689025"/>
    <dbReference type="InParanoid" id="A0A194WTZ4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="49" mass="5783" checksum="AD096F21E7550667" modified="2016-10-05" version="1" fragment="single">ITEFGPKVYMNPEIDIREEVVFVFLYIILELLLRYCTTCQLRTSVPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU04</accession>
    <name>A0A194WU04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_570473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065786.1">
        <property type="nucleotide sequence ID" value="XM_018208587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU04"/>
    <dbReference type="GeneID" id="28818313"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_570473"/>
    <dbReference type="InParanoid" id="A0A194WU04"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="227" mass="24452" checksum="77D86EB746B5EE87" modified="2016-10-05" version="1" fragment="single">VKIAILDTGIDIGHPYFAADQAGKPSERRIKSCEDFLDPKGAAQDVCGHGTHCVGLLRKVAPEADIYVARVAKDFDESLDPEVVARAILRACRDKKDENGIRNWNVDIITLSFGFYEMSKVVQKAIQEALWKPVLIFAAASNNGTQKRVTFPAWLTGVICVHSAMANGAASLFNPDASPPRNFSILGENLKSAWIRSPGNPNAEKVMSGTSMATPIAAGVAALVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU76</accession>
    <name>A0A194WU76_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pheromone-dependent cell cycle arrest protein-like protein Far11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_738943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="25"/>
    </dbReference>
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    <dbReference type="GeneID" id="28830147"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738943"/>
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    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
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        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="91"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="501"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112776" checksum="7D28AD247C313706" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUB7</accession>
    <name>A0A194WUB7_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_700450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUB7"/>
    <dbReference type="GeneID" id="28826849"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700450"/>
    <dbReference type="InParanoid" id="A0A194WUB7"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10342">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267539" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
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            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="20571" checksum="D06BC8CF0629B602" modified="2016-10-05" version="1">MQFSSLFVAAAALAVANAAQFTMTASQFVSVKTGTPFDLTWSNATGAVTLLLKNGAANNLQTVETIASGLTGTSYSWTPEATLPSGSYAFEIDDSTGPNYSIQFTLAGAASSSSSASSTSSGSSTSSSTGSSSTGSTTTTSSSSSATAKSNSTSSTTSGSSTKTTSGSKTATTTGSSTSSTSSPSSVSSASGFASPLAFVLLAVAAIMTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUH5</accession>
    <name>A0A194WUH5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_759244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065674.1">
        <property type="nucleotide sequence ID" value="XM_018221459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUH5"/>
    <dbReference type="GeneID" id="28831185"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_759244"/>
    <dbReference type="InParanoid" id="A0A194WUH5"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="401" mass="44699" checksum="0DB4EE6040BFF001" modified="2016-10-05" version="1">MGSILVEEVERKSDFNPLISNDPNHIYAEYDTLRATCPVAYTNEYNGYWLLTRYEDVKKCASDSATYISSVKAVVPSDPRGIRRPPLNFDAPRHTPYRTALDRTLKPARLKRLKGILEKRADMELAPMLDAGGGDVCMKFGAKFPAWVETEWLNLDEGSTSTLAATAAGWIKAWREQDGEKTTAHSMKMYDMAKELLAQRRENPRCPEDDPASSLLLERDPDGNPLDEVHLIGALGQSLVVGMVAPPLLIGAICNHLSKDQDLQSQLRSDLSLVPAATEEFIRLYTPYRGFCRTPSTGVTIHGRDIHAGEPITLSYTAANRDPSIFPEPDKFILNRENLTSHLGFGRGRHRCAGMPLARIMIQIALRTILRRTKGFAVCGPLEYARMPEMGIISCPLKMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUW4</accession>
    <name>A0A194WUW4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_231540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066100.1">
        <property type="nucleotide sequence ID" value="XM_018206039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUW4"/>
    <dbReference type="GeneID" id="28815765"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_231540"/>
    <dbReference type="InParanoid" id="A0A194WUW4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="420" mass="46755" checksum="DC1A5C7E8437D909" modified="2016-10-05" version="1">MGLPLFITPVEPEVAAKPEKATAGPRSSIRRQRTIRGPHSRPSAEIRRRRMLGMLADAEPEDFEPSENRQRVPTSDRTGELDGRSMFEQERMRLRDTLSFERQHRPSNEIDGLFMPPVPESRDYSGTEERQREILRLRAIRQDLRRVARRRPAPTPPYTDTDLNFMARNGPGIDSPRPSSLTPARSPSHPSVGEADVSPPRRPLEDSDFSFTVRGPPYAERAARSTLSERVQAFNRVSSNMERSRRIIRQARLDGLGDRDRSLSPENGAAWDTLLTSITPDPQPPSAGSSFASASAAAAASSSGSGPTSASTSMTSVDRSGDSTALRDCDISDSGSNTDEEDEDIYELHDFNRMRGDRFWTYADVVTSRADRAARNGGTDTEHLGGMHRIISRLASRDEIPEEWWASAGLSRNLRREPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVL6</accession>
    <name>A0A194WVL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_653618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066366.1">
        <property type="nucleotide sequence ID" value="XM_018212259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVL6"/>
    <dbReference type="FunCoup" id="A0A194WVL6">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVL6"/>
    <dbReference type="GeneID" id="28821985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653618"/>
    <dbReference type="InParanoid" id="A0A194WVL6"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="181"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="590" mass="66969" checksum="7AD934DF26A0B498" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVX9</accession>
    <name>A0A194WVX9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate synthase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_786255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066473.1">
        <property type="nucleotide sequence ID" value="XM_018222962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVX9"/>
    <dbReference type="STRING" id="149040.A0A194WVX9"/>
    <dbReference type="GeneID" id="28832688"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786255"/>
    <dbReference type="InParanoid" id="A0A194WVX9"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39554" checksum="44EC4E730FFA4B01" modified="2016-10-05" version="1">MTITWGTVKSLLLFFGPILLPKAIAYYRSVRAAPSIHGIPIRPIPPAVQRALLILLITSLSFLIRTLPNFAPENIFAITASRLQIPTDVLFTRLSGLRPQGLSPTDQLLRTKIGSLEGRLQYFRFGPDVLSECQFCNPDDPNSYLYYALPGILIPHIFNLCVLALVTSGLFTGKEGAIWRTTGTIAAIAVAIMEVYFVSSYNYQGNSRATRVEDLDFFYWKMRIYRGVALAALDGILGWVLYLSSTNRAFLTPPSTAERIETSSRILDMARSKMGATGVLRNTIVRNEALRGRSQDYWIHEGQVTRAVMEEREVVQSVQNALENRINIATISADADTYAQNIMAPLQAMQQANGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW11</accession>
    <name>A0A194WW11_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_564289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066127.1">
        <property type="nucleotide sequence ID" value="XM_018208514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW11"/>
    <dbReference type="GeneID" id="28818240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_564289"/>
    <dbReference type="InParanoid" id="A0A194WW11"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="8998" checksum="A1CA417AD0B6AB5D" modified="2016-10-05" version="1" fragment="single">ASTFRWLQRKRYQYEVTFSLYMLTPTEKFIFNSFLFLFFSMIIIAMTLYLPQHIAFLTNRAWFYYNGDENAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW18</accession>
    <name>A0A194WW18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_688619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066513.1">
        <property type="nucleotide sequence ID" value="XM_018215741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW18"/>
    <dbReference type="STRING" id="149040.A0A194WW18"/>
    <dbReference type="GeneID" id="28825467"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688619"/>
    <dbReference type="InParanoid" id="A0A194WW18"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="630" mass="69939" checksum="095F50980CD6369E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW49</accession>
    <name>A0A194WW49_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_738459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW49"/>
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        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WW49"/>
    <dbReference type="GeneID" id="28830098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738459"/>
    <dbReference type="InParanoid" id="A0A194WW49"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="423" mass="46570" checksum="FB9A2B0542755E06" modified="2016-10-05" version="1">MFGAPYICRRCFNASLKPARRRLLKFSSSATHGSFSPALLSRARNLASEQDRLSKETAESFDAKIARRIGELKGVSEALKEWEAAQDSLKELNSLLKDPTTDSELRELAAEDLSLTASQLETLSQRLATSLTPKHPFQDLPCLVEIRPGVGGGEAAIFAADLLRMYQAYCSRKGMRSSLLKYETADGDSDGQPPLAEAILEVESPGAYGELRSEAGVHRVQRVPATESKGRTHTSAVGVLVLPSLPKSGSEGQDIGDADFNDPESDYYINPGDVRTDVMRARGAGGQHVNTTDSAIRLTHIPTNTVVSMQDSRSQHQNRERAWQLLRSKLAQAKREAREEEVVKLRRGVIGIAKMGRGDKVRTYNWGQQRVTDHRSGLSVHNLDDVMDGGDDLDKIIESVKTWLGDREIETMLAEDEATNNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW98</accession>
    <name>A0A194WW98_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_699614</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066600.1">
        <property type="nucleotide sequence ID" value="XM_018217067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW98"/>
    <dbReference type="FunCoup" id="A0A194WW98">
        <property type="interactions" value="824"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WW98"/>
    <dbReference type="GeneID" id="28826793"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699614"/>
    <dbReference type="InParanoid" id="A0A194WW98"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000127">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000185">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000572">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="421"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="628" mass="70192" checksum="56446F634764138A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXF0</accession>
    <name>A0A194WXF0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_722210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067011.1">
        <property type="nucleotide sequence ID" value="XM_018218714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXF0"/>
    <dbReference type="GeneID" id="28828440"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722210"/>
    <dbReference type="InParanoid" id="A0A194WXF0"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="67"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="368" mass="41389" checksum="8567DC4B7A828105" modified="2016-10-05" version="1">MPSAQLETGKIVRPKNKDDSPLYPEYMPFYDPLEKVEDIGEFEHHDPGHRADPSMPNLLKGAKLWDISPHVGTEITGIQLSQLNEAGLDELALLAAQRGALVFRNQDFDGIGFEAQKRIVRHFGPLHVHGWAPHPVAGSDEHMIIYDHKDDLRVRKSWAGRSPVQWHTDQSPEAQTPGTTFICMLESPSAAGGDTLVSSSVQAYKSLSPRFRKRLEGLTAIHSNTDGVVAEKKNGENAVMRRGVLQSEHPIVIVHPVTKEKALYVNPVYTKKIVGYDQEESDCILRFLFDHIAKRADFQCRVRYEAGTVLVWDQRVTNHSQTLDYPVGERRHVFRLTPLANKPIPAAVEEDDDGECQRDEARVQLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXS7</accession>
    <name>A0A194WXS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_785322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067090.1">
        <property type="nucleotide sequence ID" value="XM_018222882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXS7"/>
    <dbReference type="FunCoup" id="A0A194WXS7">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WXS7"/>
    <dbReference type="GeneID" id="28832608"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785322"/>
    <dbReference type="InParanoid" id="A0A194WXS7"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="212" mass="23854" checksum="B2FDA863CE273E2B" modified="2016-10-05" version="1">MYHLAKGLYLYATSKEEYSVLLLGLDNAGKTTFHEQVKSLYLPSNPAPKLKTVPTVGQNVTTVTLPDMYIKMWDVGGQHSLRKLWQSYYQSCHAIVFVIDSTDIGDGNLEHDNSGRLEECRLVLEDVLQHSETEGVPLLVLANKQDREDCVEVVRIKEGLVKKVFEGEKGSSIRDSRVLPVSALTGTGVKEAVEWVRSRVKWNKEARPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYA8</accession>
    <name>A0A194WYA8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative non-ribosomal peptide synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_785913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066947.1">
        <property type="nucleotide sequence ID" value="XM_018222933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYA8"/>
    <dbReference type="STRING" id="149040.A0A194WYA8"/>
    <dbReference type="GeneID" id="28832659"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785913"/>
    <dbReference type="InParanoid" id="A0A194WYA8"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="556"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="915" mass="101814" checksum="F5B017BA79331827" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYB0</accession>
    <name>A0A194WYB0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_688293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067029.1">
        <property type="nucleotide sequence ID" value="XM_018215680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYB0"/>
    <dbReference type="FunCoup" id="A0A194WYB0">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WYB0"/>
    <dbReference type="GeneID" id="28825406"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688293"/>
    <dbReference type="InParanoid" id="A0A194WYB0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="28399" checksum="FAC953B86967EA6A" modified="2016-10-05" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGILAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQKYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGYDPQRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDCDLKEACGMAVKVLSKTMDSTKLSSEKIEFATVGKTKDGRIYHHLWGADEIMTLLKEHDLAKDESGADGGDRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZT3</accession>
    <name>A0A194WZT3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_672664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067806.1">
        <property type="nucleotide sequence ID" value="XM_018213297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZT3"/>
    <dbReference type="GeneID" id="28823023"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672664"/>
    <dbReference type="InParanoid" id="A0A194WZT3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="39176" checksum="8D7E4752767422E7" modified="2016-10-05" version="1">MASKRMLLNSGFFIRVLLSSCSLSPSYSIAYFFLNLIPTSQHIYSTPAIDLVFDSELLITISIAKKSIIVASRDALSGRYSQDQSSDPTTSTASSFDSQTLLLNASFDVFPKLPPEIRDEISVKRAATTCTYRHKFELLPVLLTGSLATGKLALPRLRYIHISVNEPDVDGDQPIATYPAVKIRTQVPGMLGACQHSRAIAFKYYIPQLHIRFDGSPINIDHETDIFAFESERTIPGFFGDDSRWNDEMEAFLGNIRKIMVRGRQLSFCVGIFFTVLKKVKHISLETESALTLGLSNTVGFKYNKTYDMLRQSWQVWGRSNEEFPTLHVVSSGKMDELVAAGRSVMGDSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZU9</accession>
    <name>A0A194WZU9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_737451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067826.1">
        <property type="nucleotide sequence ID" value="XM_018220256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZU9"/>
    <dbReference type="STRING" id="149040.A0A194WZU9"/>
    <dbReference type="GeneID" id="28829982"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737451"/>
    <dbReference type="InParanoid" id="A0A194WZU9"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="437" mass="49854" checksum="C8FE1258D99B264C" modified="2016-10-05" version="1">MDMIKDHDSQRGGAIVVPKVVDPSLFFEFGDDRYVAWPDVSELKLHFLTEHSSVTVISLPQGRSIDTDWLEAHITESLELDDVLREDFLQTILLAGPGTEQLSSIQPFERLTNPQSRTWKIKRIESVGWQSGLLPGPYIVVGDQLWQVLRLYDDTQGAFLAPVRKSIHGRDLTKLSNFADKWYTETKPRTKQKELPMAIVVPIDLFPTADTPQKRLVLKLVEDLEKHLKVEAQRVSISGLWDDQPPQAAAGESLQDYLREVGANTFLYENYHSTANFRDDYRKKFGRAPFSSPFVTWRWKIGKQYTAEQHEEGMRRMKTYAEWFLDTVMQVGTANTAYYIQPAWHQWWISPILGAPEIVVPVGQLPYESRISNQTEYLPVTASIMSQPGTKIVAILDTTATSIIIDTDMTLIEFTETFMKDVGRSLVVQSGKIMFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0K5</accession>
    <name>A0A194X0K5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_146138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068080.1">
        <property type="nucleotide sequence ID" value="XM_018205356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0K5"/>
    <dbReference type="GeneID" id="28815082"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_146138"/>
    <dbReference type="InParanoid" id="A0A194X0K5"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267745" evidence="9">
        <location>
            <begin position="17"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="48"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ13725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="39346" checksum="57FD362FA816E332" modified="2016-10-05" version="1">MKGFLVLALLFQLVASSLHSNFDSYPEVWRKIIINKLAGYHKPFDPVPRLVTYVQTFEDKQGKHVSLLPLLWHDVKVTHVILASVHLHDRPGEIRLNDHSFDWDEYSRTWQEVKALQNHGVKVMAMLGGAAAGTFKHLNGSEEEFYSYYHPLKKLLIEHQLDGLDLNIEESVPLAVPIRLLNALHRDMGPHFILTMSPIASALLSPANTDQNLSGFSYFDLDAFATIPGSETKLISWYNAQFYGNFPRGPPLYEQVMEAGWPAERIVMGVLDSPDDGPPNGFLLMRDLRMRIAALKRKWRDFGGVAGWEYFDGGTGDGVVDKPWDWLLGVGYELFGRDDDHSKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0V1</accession>
    <name>A0A194X0V1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_699338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067949.1">
        <property type="nucleotide sequence ID" value="XM_018217049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0V1"/>
    <dbReference type="STRING" id="149040.A0A194X0V1"/>
    <dbReference type="GeneID" id="28826775"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699338"/>
    <dbReference type="InParanoid" id="A0A194X0V1"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="501" mass="54350" checksum="2EA57369DC84C1A7" modified="2016-10-05" version="1">MHHKRAPTFGALFRADSSKLLPTSASSDDPLLAALTTVQEQYITANDQSHKAHEEACHDFPGGNTRTVLHASPFPLTFIKAKGCELTSLDGTTYVDFLGEYTAGIYGHSNEKIAAAVSECMSRGWNYGGPNIYERQLARKVTERFSPSGIELVRFTNSGTESNTMAIAASLVVTGRKTVLAFKNGYHGGTLSFPITLKDINVNLPHDFVLAPYNDIEGTKAVIASLPKDSVAAIIVECVQGSGGCIVGNVDFLSFLNKAANELNAVFIVDEVMTSRLSYHGYSSELGLRPDLVTLGKWIGGGMTFGAFGGRKDDGIMSLFDPQVGMLGHSGTFNNNIVSMAAGCVGMDIYNEEQVKRLNALGESLKLKIEVVLETHGVHPPATMKAGTSPLNQEAESPFTGLESEPSLANGVVAELQQHESGGRAKNHMWITGKGSMLCVHFSGECEMSLKALYWHHMLDHGIYMAQRGFMALNIELNEEHIERYAKAVEEFVVKWKPALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2I7</accession>
    <name>A0A194X2I7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_138290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068765.1">
        <property type="nucleotide sequence ID" value="XM_018205295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2I7"/>
    <dbReference type="FunCoup" id="A0A194X2I7">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2I7"/>
    <dbReference type="GeneID" id="28815021"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_138290"/>
    <dbReference type="InParanoid" id="A0A194X2I7"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="79"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ14410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="464" mass="50790" checksum="27077337275C5124" modified="2016-10-05" version="1">MSSAHKQKSVFVGSFVHSKSLEVLEVLHDLAVFVDEKGVIVAIEEHCDKQQALQVIAPKLGWTIGDVSVRVAAPGQFFFPGFIDTHIHAPQYPNVGIFGKTTLLDWLNTYTFPMESSLSSISKAKRVYTRCIQRTLSHGTTTASYYATISVPSTNLLSDLCLTLGQRAFIGRCCMDSLAPDYYRDESAATSIADTKATMDHIAKIDPTNALITPIITPRFAPACTRELMHGLGALQKETGFPVQTHISENKNEVKLVKEMFPGFESYTHVYDGHGLLTPKTILAHAVHLTEAEVDLIKAREGKISHCPCSNSAITSGTAKVRMMLNKGLDIGLGTDVSGGYSPSILEAVRQASLVSRHVAMEGDDDSKLSIEEVLYLGTKGGAKVVGLEDKIGSFGLGMEWDAQLIGLGNVPVDVDQDGIEEESPVDIFGWENWEERIAKWVFNGDDRNTLAVWVKGRLVHERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X319</accession>
    <name>A0A194X319_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_143692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068950.1">
        <property type="nucleotide sequence ID" value="XM_018205332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X319"/>
    <dbReference type="STRING" id="149040.A0A194X319"/>
    <dbReference type="GeneID" id="28815058"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_143692"/>
    <dbReference type="InParanoid" id="A0A194X319"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="488"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="743" mass="81862" checksum="020E2CC067794766" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3G1</accession>
    <name>A0A194X3G1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_686400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069088.1">
        <property type="nucleotide sequence ID" value="XM_018215273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3G1"/>
    <dbReference type="FunCoup" id="A0A194X3G1">
        <property type="interactions" value="1387"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3G1"/>
    <dbReference type="GeneID" id="28824999"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686400"/>
    <dbReference type="InParanoid" id="A0A194X3G1"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="175"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="380" mass="43575" checksum="83FD3CFDB4620B79" modified="2016-10-05" version="1">MNIDTIPEFLAEQTEKAHSDLQPLFLDFEDLWEKKLWHQLTDALIEFFNHKESASQRLDIYKKFILSFADKINQLKLVTLALSAATQCKTSEERLSFLTALANKVNGPNSQDAYVYATVAVATIKLELDDKDGSRKDLDKSEKILDGFDSVETIVHAAFYRVNAEYFHSKGEYASYYRNALLFLACIDLNDLTPNERKQRAYDLAIAALVSDTIYNFGELLLHPILDSLKSSEEWLYKLLFAFNAGDLIAYDSLANHITSNEILRQHQDGLRQKIYLATLTETVFRRPPHDRAMSFSTIAEETKVRPDEIEHLIMKALSLGLLRGSIDQVDEIARINWVQPKVLDMKQIDNMRARLQEWDSNVNQLGHWIEAKGQDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3L3</accession>
    <name>A0A194X3L3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_649312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069140.1">
        <property type="nucleotide sequence ID" value="XM_018212052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3L3"/>
    <dbReference type="STRING" id="149040.A0A194X3L3"/>
    <dbReference type="GeneID" id="28821778"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649312"/>
    <dbReference type="InParanoid" id="A0A194X3L3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="403" mass="45707" checksum="1B2B0447B4C5402F" modified="2016-10-05" version="1">MLAGQGLEILAERYQDEVVGQVRSSSQVPDGDGWTELPDLISFVECHVLEAATRALYGPHLVGLNPTIAADFWNFNRRVKSMFMGVPKWMNPLAVRARNKMTDNIKRWQRYNAANCNIDDIPEEVEWEPFYGSKYTRVRQQLLTKRGIMNESARAAENLAFVWATNANSVPAACWFLLETLHDPSLYKRVQESLQGARITDTDKSLAFDMTKLTNDTLLQSIFAEILRLRVAALVVREPTVDHFSLPGGWYIKQHETISMSTRTELMDPNVWNAGNAASPHPLDKFWAERFIVYPDDPRSGPLKEPKRRLKPAPSKDGKSTNEGSFSLDGCTWHWVPFGGGRQLCPGRHFAKREILLTSAIFLSTFEIELMVDKLPGPDKGIYGFGTMPPKGKVPCRIRRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3M1</accession>
    <name>A0A194X3M1_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_122363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069148.1">
        <property type="nucleotide sequence ID" value="XM_018205160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3M1"/>
    <dbReference type="GeneID" id="28814886"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_122363"/>
    <dbReference type="InParanoid" id="A0A194X3M1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="85" mass="9912" checksum="3CBE009A31596947" modified="2016-10-05" version="1">MQPCMDVITWNGTDMQFFMTMISNFKFTFWLAACVHSLKGRVANNYRHLSQYLTGLRTSIINHLQMAKTIARCYFCLSQLSHTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X484</accession>
    <name>A0A194X484_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_736043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X484"/>
    <dbReference type="GeneID" id="28829805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736043"/>
    <dbReference type="InParanoid" id="A0A194X484"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267890" evidence="2">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="10350" checksum="4AE2C8A709261881" modified="2016-10-05" version="1">MKTFSFSIMLAILAAVTTSSAAHSTTSSTEPTIVSTSTLVETLTPYVYQTSTLPTTSSVSTNTASNTPTSTATGTSGGYRVQSDGFELVWMAVALTGILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4B0</accession>
    <name>A0A194X4B0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_686591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4B0"/>
    <dbReference type="GeneID" id="28825044"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686591"/>
    <dbReference type="InParanoid" id="A0A194X4B0"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="3">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16794" checksum="2C2706E1B8F21ED5" modified="2016-10-05" version="1">MPSKPTLAIIGAISVIALFSLFKFPFSSLNHTEPLFPPSSKDGIVHIVMFEFKEEATAEQVTDVCDRMLALKQKCLHPTTKKPYVKMGMGGKQNSPEGLTGGMTHIFVEEFENEQDREYYLNKDPVHLAFVKSIGDVVKTAQVVDFTPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4W7</accession>
    <name>A0A194X4W7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_783413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069576.1">
        <property type="nucleotide sequence ID" value="XM_018222681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4W7"/>
    <dbReference type="GeneID" id="28832407"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783413"/>
    <dbReference type="InParanoid" id="A0A194X4W7"/>
    <dbReference type="OrthoDB" id="10314070at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="170" mass="18717" checksum="66C45D2681AE4A0E" modified="2016-10-05" version="1">MATAQSWQPRQPTTPYPLDAYSALPSLHFLPNNGDSQLHPANPTPGFEPETLQKLFAEELRVQASISMCFRLERLLGAELQETFVLLETAEAGNTNKERGLDEAKKEIEHLNSMLEAAFDHKQAPVEPSSQSEESSDDGALAVLPMMPLKRKVDQLPGPSPKRPLISAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5I1</accession>
    <name>A0A194X5I1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_698204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069780.1">
        <property type="nucleotide sequence ID" value="XM_018216967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5I1"/>
    <dbReference type="GeneID" id="28826693"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698204"/>
    <dbReference type="InParanoid" id="A0A194X5I1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000394">
        <property type="entry name" value="Zinc finger protein 836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="47299" checksum="043F4013FAF289CA" modified="2016-10-05" version="1">MDVMELVENEPNARPFQCDWQTCNKSFNRKSDLQRHYRIHTNERPYSCMTPGCGKSFIQRSALTVHIRTHTGEKPHQCQHIGCGKRFSDSSSLARHRRIHTGKRPYKCAHEGCLKSFCRKTTMVKHQRRSHQRGVHSSELDDGDTSDSDSGESPSTPQHPGHVQWPQTVQIPQHMPHGHHMHRAHSFADFGHHQIDNYPMQQNFGHRHSLSSGGAQHFNGPIQEHGHHNPIMHRAPSLPAHSSYYVPEQNNPGVATLNTNPTPIQTYQIPRQLERQEVLQSSPSSYSSASRASPVSQEPFYTHHPAQAATYALQNSSPIEQQPMVQYQQQMPQHLAQHHGLPQPISQPHQQEQFHSPAPQEGQWYDNVAYQAPVEVISHIPSYPQTHVFTDPWAQKIEAFDDPSLQMPSARIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5Z8</accession>
    <name>A0A194X5Z8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_719338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069961.1">
        <property type="nucleotide sequence ID" value="XM_018218487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5Z8"/>
    <dbReference type="GeneID" id="28828213"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719338"/>
    <dbReference type="InParanoid" id="A0A194X5Z8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="39042" checksum="717125F808520A1D" modified="2016-10-05" version="1">MLIKIPDTDKEDTMRDPIHNALDAGLRALGGEKGALASFWRKLREKDKKGSRVHKESDDPSDDGNYEGYLRSMKRERRYSPPMPGVGQRYGGRAYGGLGQYGGYGPPPFPFPNQDRDALNPMPNERPIPYGLGRDRDRRDRRRGPNTPYGQPPLPIDNSWRPLLGYGIRDRGQIDRALLQYAQQEQLARAGRGRGQLPPFMPPPAYGRRSEPILNPRDLLRSPPREIREPAGRPDKKRRNSPARRPVPEPKRTVSAPAESKRPEKTPNKISKGEKKKEEPKMRSPPPATPPARPSPEKSVSTHSSQDDQSSIATRRRLGDMNRTFIEGMVSKTTLVSSSWSVPSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6Q1</accession>
    <name>A0A194X6Q1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_587277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070203.1">
        <property type="nucleotide sequence ID" value="XM_018209420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6Q1"/>
    <dbReference type="GeneID" id="28819146"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587277"/>
    <dbReference type="InParanoid" id="A0A194X6Q1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="610" mass="67582" checksum="00E75EE0EBA3EB00" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X785</accession>
    <name>A0A194X785_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_685889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070386.1">
        <property type="nucleotide sequence ID" value="XM_018215164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X785"/>
    <dbReference type="FunCoup" id="A0A194X785">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X785"/>
    <dbReference type="GeneID" id="28824890"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685889"/>
    <dbReference type="InParanoid" id="A0A194X785"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ16031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="925" mass="103445" checksum="2DA101AC4BB1396E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7D6</accession>
    <name>A0A194X7D6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_685926</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070443.1">
        <property type="nucleotide sequence ID" value="XM_018215173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7D6"/>
    <dbReference type="FunCoup" id="A0A194X7D6">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7D6"/>
    <dbReference type="GeneID" id="28824899"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685926"/>
    <dbReference type="InParanoid" id="A0A194X7D6"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ16088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="575" mass="65665" checksum="10543802F6BADD0D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7E2</accession>
    <name>A0A194X7E2_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ16093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="441" mass="49927" checksum="E5235D6F7673F069" modified="2016-10-05" version="1">MFNEQQWLPTSELKEKLSTPRNTRIVINHEGHSKVSLTRTHQTTLDPATQLSKEVIAHLEDSKPAGIHIRNLGYFFDFIPSRLGLSKALDDSVRCILTAYTALLRRDAVVLRQDREEYYQAVKSLRIACADEKEALSDETLCAAVLLSWYEVLADNLDESWFTHISGTSHIIKLRGPARHRSGFGLALLKAQEGLISGEAMATFQPCFLDDPAWCEILDDQNMVVGLPQTAPLTVSNKILAQLSTLLLEARKLHNLSQKGIREIIKQLWGLRRTIKTALDQVTEMAEKDEEEFAPIICCKDSIYLILLDTTILKVLGFSDSKDPQLPETVQELQDLSLPPQTFTDVELFKQAIDSQIYQNFNTFLSNLALASKVTPFIMRKMAFMCRIMCVERGKREENPHPIWARYKRAISGVNEPDWLSRIIASFKPILPPANKSSGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X856</accession>
    <name>A0A194X856_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="45080" checksum="76D85E14C26FCE79" modified="2016-10-05" version="1">MKLSLSVLALLALRSVSSISATLITASPSKTAVLAGRQFSSASLASCSTVSGLASPQPSGAVCGELANSDGTGYLISYVAGSPYVASLAALSGFAKPQPANTTCGVLAFSNGSGTIIDYTNGVYTENAATCGQICLATTGCTNVYFEAGAYCNLHSGPPTNLASSSSPYTFYDLSCFTCQDVIYSSSSSSTSTQTSILSTAQSSTVSSTSSVTTSVTSSITPISSESSTTPTTTASWTWTSVQTNPALYNMALTTTYTQSPQCTTGAITEMAAWGPYLWDNSVNPLPTSTMTTCYPPQFYSSVIGILNNVTLPAFSALVCPYEWDTIPYNASYIACCPNGFGLIAPNYASNSARPFSGALCTSNIGFGQVYDVSSYNSTAYWTVIPVTATAGTVVFADAFDGITAPATTSTLLITSSSTKSSSFTKSSASTTATTSIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8R1</accession>
    <name>A0A194X8R1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734661</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070918.1">
        <property type="nucleotide sequence ID" value="XM_018219928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8R1"/>
    <dbReference type="GeneID" id="28829654"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734661"/>
    <dbReference type="InParanoid" id="A0A194X8R1"/>
    <dbReference type="OrthoDB" id="3532133at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267979" evidence="2">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="414" mass="45268" checksum="8BB648CE74E34271" modified="2016-10-05" version="1">MHLTALFLLPLPLFVLTHPVIVEHETIAAHPIQNHVDPLHPIQPRCVTVRTTRSLTEPETTMRVNPHTTAPHRPSNPQNKSLISRALSILRIFNPHSTTPHSPSETNFPKYQPRILTRTLSRRDSVTISISNTFNSTTVCNSQNDAKFEVVNNAKNADITVGDNTSHTSNFHTFGNKNMLNSTGSNTGGWNTKNTGSNLTTHREPKRGVGKRDYIGWKGWFEDILMGGDYGRWEMPWRAPTPGTSKGDKPKWGSGAAPTKVASHHTSSSSLGAEPTFTQNPKPSMVPGPSWKGNKTDPYRPNHSGHGWPRPKFGNHTKNGTVQDGEEHKRDIVNLNIMGGSLNSTLARSGNNNTVEVYVMGNGANVVNVTVVWEGEGTDMKDSGNGNTVRVYIGDSNGVDMGNSTLQVVGGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9N2</accession>
    <name>A0A194X9N2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_65883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071189.1">
        <property type="nucleotide sequence ID" value="XM_018212494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9N2"/>
    <dbReference type="STRING" id="149040.A0A194X9N2"/>
    <dbReference type="GeneID" id="28822220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_65883"/>
    <dbReference type="InParanoid" id="A0A194X9N2"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="182" mass="20059" checksum="31821E72D5053BE9" modified="2016-10-05" version="1">MVRLNLTSLSTLKISRHQIPAHGLIPNTSIQKQPLLIYHSCLPTSATASTIEAHLNAINVVTPQWRYTMYSTTHFHSTTHEVLCISSGRAKLCFGGEDNPGRFEPVVEKGDVIIVPAGVGHRLLDDFNSGFEMVGSYPKGKQWDMCYGKKGEESKVKGIGELGWFEKDPLYGDEGPVLQSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB26</accession>
    <name>A0A194XB26_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_746879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071704.1">
        <property type="nucleotide sequence ID" value="XM_018221106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB26"/>
    <dbReference type="GeneID" id="28830832"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746879"/>
    <dbReference type="InParanoid" id="A0A194XB26"/>
    <dbReference type="OrthoDB" id="3625478at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051344">
        <property type="entry name" value="Vgb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274:SF3">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="31510" checksum="575E176CAFF540CB" modified="2016-10-05" version="1" fragment="single">EYPIPYTLPALPFSSLPGYSLTSGVTALACAIRPGEDGNLYAGSGIRNQFIRINPTTRKIDVFTPQPFDPLGDLQPFNDLTAGPTGMFFSQSTANLITHFDYTTEQFTNYPVPTPLSAPLGMVFFEGYLWFAELLGQKIGRLSPTTGSVTEYSVPLPTLSGPGVVRATFTKPSRICFTAILGGSNGCLHTDTGTFDVYPGTGIGAAVSIPGENTKDLRFDDIIYYSTATQNYINILNITSGQVSKIVEPTTVLAEPISLPFYFDIGMNYGPGKAVWFTQAISNRVGRYQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBN1</accession>
    <name>A0A194XBN1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_583916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071926.1">
        <property type="nucleotide sequence ID" value="XM_018209238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBN1"/>
    <dbReference type="GeneID" id="28818964"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583916"/>
    <dbReference type="InParanoid" id="A0A194XBN1"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268109" evidence="5">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="45"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="500" mass="54022" checksum="85247DB13343E0EE" modified="2016-10-05" version="1">MLSTSLFFLVLFALVRAQDDNDSTDPAALPVVTVNVSTSQTYQTISGFGISQAFNRAASIYHLPNATQSKILDLLFDDSVGAGLTILRNGVGSSNSTALDYMLSIEPNPPSTSISNGTATYAWNGNDSSQVWLSQQAQKYGVQTFYASAWSAPWYMKSNENDQDGGYLCGVTGTKCGTGDWRQHFANYLVQYLREYQDAGINVTHLGFLNEPDISPSYAGMRSNGSQAVDFLKILAPTLQSSNFSHVKLVCCDNTGWSIAGATLSELQSASGEKYLSVYSAHGYSAAPTDPLKTSLPVWQTEWSDLTTPFTALWDSAVNTTDDDTGDVTTTDGTEVDGFVWATNIQDSLVKANVSAFLHWMGAEESSGSDMLIRINSTTNSYTVSKRLWAFAHFGRYVKPDSRRIYANSSAAWEDFSVSAFESANVGRSGIKSIAVQVINKGWANVTVSMRVEGAREGGVVLPVTTNEGVDVGSGEYLAVWEGLVNATVPARSLMSFVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC07</accession>
    <name>A0A194XC07_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-serine dehydratase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_645282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072046.1">
        <property type="nucleotide sequence ID" value="XM_018211873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC07"/>
    <dbReference type="FunCoup" id="A0A194XC07">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XC07"/>
    <dbReference type="GeneID" id="28821599"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645282"/>
    <dbReference type="InParanoid" id="A0A194XC07"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="1">
        <location>
            <begin position="320"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="450" mass="49906" checksum="7E8253B8C233A99A" modified="2016-10-05" version="1">MATTRWALRSQTSLVEQFVGQSLHDIPLPAAVLDIAKVRRNCARMLEAVDELNFDFLPEVSSHKTTEITRLQLGANAEEVRVLVTSLWEATKLLPLLLDYQITGVQVNITYGVPLTPSQVEDAAEISKQLGRRGGNIRFLLDHISQVDLVEQVGETSGYPPRVYILVDIGDGFSGVRPGTPEFRQLFSRIEQIVLSQGSQSLAFVGFYSDIAFPDESSDLVSHLRLLDRQLAMLLHASPIEVLRLTVRAPPNLWLSLHATEELSSRELSKLKHTLVATSEANHAIEAHSGDYVTLDLRSLVHNSQATFDGTAALMYDDIALTILTEVSSLYPRRGENGRLEAFISVGGSAFQDGVGCGGVVSQWNMKSRSALNTDSSCEWEISRCRGDSAVLVWIGENEPSADSLVGQRLRIYPYDASRAGDRFAWYYVVDSSRLGREDEIVDIFVRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCF8</accession>
    <name>A0A194XCF8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_683848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072210.1">
        <property type="nucleotide sequence ID" value="XM_018214766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCF8"/>
    <dbReference type="GeneID" id="28824492"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683848"/>
    <dbReference type="InParanoid" id="A0A194XCF8"/>
    <dbReference type="OrthoDB" id="3597476at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="726" mass="82671" checksum="F9A749AFCBDBB513" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCV1</accession>
    <name>A0A194XCV1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_34711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072353.1">
        <property type="nucleotide sequence ID" value="XM_018206891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCV1"/>
    <dbReference type="GeneID" id="28816617"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_34711"/>
    <dbReference type="InParanoid" id="A0A194XCV1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="139"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ17998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="521" mass="59501" checksum="F812F3FBE62DA6B1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD47</accession>
    <name>A0A194XD47_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_37540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072455.1">
        <property type="nucleotide sequence ID" value="XM_018207087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD47"/>
    <dbReference type="FunCoup" id="A0A194XD47">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD47"/>
    <dbReference type="GeneID" id="28816813"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_37540"/>
    <dbReference type="InParanoid" id="A0A194XD47"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="711"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112596" checksum="9649514D58CF14C6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFP9</accession>
    <name>A0A194XFP9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_780956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073348.1">
        <property type="nucleotide sequence ID" value="XM_018222437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFP9"/>
    <dbReference type="STRING" id="149040.A0A194XFP9"/>
    <dbReference type="GeneID" id="28832163"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780956"/>
    <dbReference type="InParanoid" id="A0A194XFP9"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="300" mass="31802" checksum="2B848C16C7054E84" modified="2016-10-05" version="1">MSNPSAPSIPTSPPPGKDPPPPSATTSEPFPPLTTETPPPTLSKPEPPIRPTITTQPPSRSTTFHASTSEEPHPVRPPFSPFFTLINDVKEKESESSTYHPSRIHYLFSDDDASEVLSAALLRGLDNQPIPPPSINSSIKAEERESTTGSSSSATFKEKKSHGKKNSGDKGTREERIIIVDMNDTGDSIKSISSLSERWQVLNAHIDNAPTWDGSSVGEGEEAAAGGLMLRIEGVSSEGRGGVQMGESEKVGVGEEEMQGLLEGFDRKMAVLRRVVGQQGDVSGHRRSGSGGSGESAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFS9</accession>
    <name>A0A194XFS9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_717476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073339.1">
        <property type="nucleotide sequence ID" value="XM_018218351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFS9"/>
    <dbReference type="GeneID" id="28828077"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717476"/>
    <dbReference type="InParanoid" id="A0A194XFS9"/>
    <dbReference type="OrthoDB" id="3561583at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="30271" checksum="DF3A360ADDAD9711" modified="2016-10-05" version="1">MSTNPTSEDVTPNQLIESPNMVLAFTLFPNLPVELRLKIWKEAAHITRNVDIWIRRAKLISDDWLVPNLDHLGYPRSYFYFISASPIPSILHVSHESRSEALIHYQLDFATSREIHRSITSINDKRRDQSFEAHTYINWKVDRVCFMNISRGNRAAMDTFMAKCLDNKVRTTALGVQMAVTSQPNGDIAFLNWMYNLRANWPLKHMMRLRNLLHGSLEELILFHSFEQGAVSLPWKVPAEQDQRFLRDGASTIDLKDTFAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGW2</accession>
    <name>A0A194XGW2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_489231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073724.1">
        <property type="nucleotide sequence ID" value="XM_018207880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGW2"/>
    <dbReference type="FunCoup" id="A0A194XGW2">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XGW2"/>
    <dbReference type="GeneID" id="28817606"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_489231"/>
    <dbReference type="InParanoid" id="A0A194XGW2"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06551">
        <property type="entry name" value="LPLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="100"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ19369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="38552" checksum="1E6649BDC0C27B1C" modified="2016-10-05" version="1">MEKYSQFRDRGSGIAPFFPISSTPAGIYLPVHIFLFLFKLPFFVTVATTYFLFLQWFPLGSLFKKAILWMILGIPGIWWIDLQIDGVKKGSLAKKHEGRIPQPSSIIASSFTSPIDSLYLAAIFDPIFTVSYPHTRQVRRISLLGAILRALSSPQDQPPKSAKLTDLKTLLVENPQRVVVVFPECTTTNGKGILPFSPSLLTTPAQTKIFPISLRYSPPDITTPVPRHYWSFIWNLLSQPTHCIKVRIAEVVYNTSKPTDHATEKKDRYLTNFLDTLGEDSAMTSSTDTLTSLSDQPAEVNPEEKRILDKVGEALARLGRVKRVGLTVKDKAAFVEAWSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHC0</accession>
    <name>A0A194XHC0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_642613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
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    </dbReference>
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        <property type="entry name" value="DUF7791"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="255"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="47294" checksum="63594CB87E30E026" modified="2016-10-05" version="1" fragment="single">MKYIFRHSKTLLLLRDWAGTSELCTAGFFFWNSGLSLQCSQNGLFRSLLYEILCKYQELIPAVLPAQWGVRYTSKCQARHCPPESWELSTLQKAFTSLISQTKVDLKLCLFIDGLDEYKGNEDDIAALFGEASTSENVKICYSSRPHLAFVEAFETRPRLRLQDLTFPDIRRYIHDRLETNIRMQQLSQAEPEATKKLIEEIGNAANGVFLWVTLVVTSLLRGLSKHDNIRYLQMRLRGLPEELDNLYHHMVYEVDNIYQQEAAKMFQLVDTNFQTRENRHPSPFREKQDLTVLFLSFASERDTNLAFEAELGFMTFQQVMDRCKDMERRLGTRCGGLLEVQYRHDYDNHDLSYEAGLYVSPNMTITYLHRTVKDFLELPETRRLLADRASGPQTNTFNTIHAFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI67</accession>
    <name>A0A194XI67_MOLSC</name>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GeneID" id="28822699"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667409"/>
    <dbReference type="InParanoid" id="A0A194XI67"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34669" checksum="E2BA5A7BBD921A2A" modified="2016-10-05" version="1">MGSIERPTLQRIPVHAPIEVFIEAIKKDGGCICTNYVSPEDIATANAEVKPFLDADKPWQGKLFPPETRRCNRLLWRSPTCREKFFMHPLYQALGEHFLAETYPTWYDEKCHHYTSHPLLSAALGIDVRPGAVGQRLHRDDKMYHTWHTDATSTGWTQGRDNGFGVFVPGIKTTVENGATRMLPGSHLWGDDRGADPNDPNVCYAEMDVGEAAFMLASTFHGGSTNNSKDQNRMLYAIFMCKGTLRTEFATLIEYPPEVVKPWSKEVQARLGYKISSPNCGMVDMRDPGFLLRDDFDPEAPNVDVDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIE9</accession>
    <name>A0A194XIE9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_772557</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074261.1">
        <property type="nucleotide sequence ID" value="XM_018221911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIE9"/>
    <dbReference type="GeneID" id="28831637"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_772557"/>
    <dbReference type="InParanoid" id="A0A194XIE9"/>
    <dbReference type="OrthoDB" id="10661583at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23709" checksum="25DC8D8920858284" modified="2016-10-05" version="1">MKYERSKYCHPSSLSLHKVSKSPTLYNTWKTLCHSQTHKMPPKKAPKAAKDGPSDGMDSFALNHDESALLWAMMGEMNLLDRTKGITWDVVRGAVHSTTPEAAKRRWYTLCAKMEKKGHPLPESAGKAKPQPKEKKAAGKKGSKVEEADKEESEEEEEASGPALKANKRKGKGPEKPPKAKRPKKEELSSRTVESEDEASEEAQEVSREVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIG3</accession>
    <name>A0A194XIG3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_579776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074269.1">
        <property type="nucleotide sequence ID" value="XM_018209027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIG3"/>
    <dbReference type="GeneID" id="28818753"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579776"/>
    <dbReference type="InParanoid" id="A0A194XIG3"/>
    <dbReference type="OrthoDB" id="2247093at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60073" checksum="0619A8EFAE46084E" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIQ0</accession>
    <name>A0A194XIQ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_612099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KUJ20038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074393.1">
        <property type="nucleotide sequence ID" value="XM_018210604.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28820330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612099"/>
    <dbReference type="InParanoid" id="A0A194XIQ0"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000319">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="208"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="236"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="343"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="388"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="460"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="491"/>
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        <location>
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            <end position="524"/>
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    </feature>
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            <begin position="62"/>
            <end position="526"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="550" mass="60705" checksum="482A9DD785B22B7F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKQ2</accession>
    <name>A0A194XKQ2_MOLSC</name>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
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    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKU9</accession>
    <name>A0A194XKU9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_610516</name>
    </gene>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018210550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKU9"/>
    <dbReference type="STRING" id="149040.A0A194XKU9"/>
    <dbReference type="GeneID" id="28820276"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_610516"/>
    <dbReference type="InParanoid" id="A0A194XKU9"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="159"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="37650" checksum="AAAD4E305B0D75EC" modified="2016-10-05" version="1">MGIALSLPVMGYFLMPSLTSYSTSLNLLFFYMTWSTLVLSQPPLKVELVGTAAIRTLFFFIPALLFLIVDSIVPSVAVSFKTQGLQALPTRTGGGRGSRRGGGSEWYKVIGLSLFNICLGIAIQAGVELLFTQVLGFRSALKVTTTLPMPWSILKDVARGLVLREILQYYAHRFILHPKSPNYISRLHQTYFHSITAPYSFTAHYDHPLPYLLWRFLPVYLPSIMFRVHLLTYLLLVSIITIEETLAMSGYTTVPGIILGGIARRQDLHSEGQGQGNFAPYGLLDWIHGTGIGPDVIDDMRDEAEKHNVKERSGKALENAKDSGVKAWNGRKKNSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL18</accession>
    <name>A0A194XL18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075181.1">
        <property type="nucleotide sequence ID" value="XM_018222301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL18"/>
    <dbReference type="GeneID" id="28832027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779523"/>
    <dbReference type="InParanoid" id="A0A194XL18"/>
    <dbReference type="OrthoDB" id="5230873at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268371" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="19061" checksum="2FFF5F70EFE87F84" modified="2016-10-05" version="1">MILSPLVQWLLVAGASAIPHAENKRAATSDVTIYAYGSTIAGRPILADSSGNAYVSNAEVQPANLSSITWSISPKGTADWTVTLNSTNSTTTTSGVFYIIPSDDSYEPVGFVINGTTPSGTVTSGFLTYGSVVQYKADSVLTSEFWAEEIEGTDQYLIKWNADGSHKDGAIPVTLQTTGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLH8</accession>
    <name>A0A194XLH8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_577543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075388.1">
        <property type="nucleotide sequence ID" value="XM_018208901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLH8"/>
    <dbReference type="GeneID" id="28818627"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577543"/>
    <dbReference type="InParanoid" id="A0A194XLH8"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23760" checksum="DECAB9E749EB2C54" modified="2016-10-05" version="1">MFRSAILRRILLAPPAVRTSLLPIASRTSFNSISARQYASVPNVAQTSFWLSLIPKPLRKSSPRAALKKKAKSKEWNPATFFIIIFLLIGSMSIQMIALKNESAAFTRRADAKIGLLKEIIERIQNGEEVDVEGLLGSGDKEMEKEWEEVLQDIEREDQEWQQSRRTKPKHGRNLESTDNTPITQTPEAKDIPKAPEAKGDSTRKAPVGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLL2</accession>
    <name>A0A194XLL2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_577222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075423.1">
        <property type="nucleotide sequence ID" value="XM_018208878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLL2"/>
    <dbReference type="STRING" id="149040.A0A194XLL2"/>
    <dbReference type="GeneID" id="28818604"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577222"/>
    <dbReference type="InParanoid" id="A0A194XLL2"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ21068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36470" checksum="9E3DF6A636279B1E" modified="2016-10-05" version="1">MSSSATSDVTLLTEHFTYRPTALIDDIVNSINVLAFKATEAVEKGLLGANPSDLGFKIPPPTTPEAQEAGRAIAEAAKHEIENGVHQLETLLETKIDRNFDRLEIFALRNILSVPPEVRDWVRLSHYEGLTFTQDKDAPNSESVTLLRKKLRETQKLHALLRAEKARNEATINALKALVLNQATKKEDVDGETYPAFAFLQNKGELMGDGKQPVTTTAEFTLSQVPSLKSLLDNLEPRLEQLANGNGEEGLVGEDQKSWRRERLEFIEKETRRHMENVRGLELGEMGEVRDGEWQGEGRKLGKGEVEDLERVVSMVGGDGGDPMEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMJ5</accession>
    <name>A0A194XMJ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_665815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075738.1">
        <property type="nucleotide sequence ID" value="XM_018212868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMJ5"/>
    <dbReference type="GeneID" id="28822594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665815"/>
    <dbReference type="InParanoid" id="A0A194XMJ5"/>
    <dbReference type="OrthoDB" id="10665921at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="253" mass="28921" checksum="5007763364B120E4" modified="2016-10-05" version="1">MSQDEQTLLKVTSSCADNPPSTDDMLDDTPITIPRSQFQLLHLHINELQKDVQEAKEESAHYMKAAKDIPKSKFSIHKKTEKLFQDMDLAKSRAKRHIGKRMSEMDERWFEGKKRNRILTEEIAQLRMMLATTIRKRQHEGRKNTTVKSDVGRDVENDMRSNRKKRKAVEEADTTIQECSTSFKKMKVNETVRGSEEGYMTNEGVEVMPSEGNSEHDVQGMVEEAVEQAFADVLAGCAALKQEVDDCDIIAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XML1</accession>
    <name>A0A194XML1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_609882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075684.1">
        <property type="nucleotide sequence ID" value="XM_018210535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XML1"/>
    <dbReference type="GeneID" id="28820261"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_609882"/>
    <dbReference type="InParanoid" id="A0A194XML1"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="42015" checksum="EC419FB5FF88F53B" modified="2016-10-05" version="1">MSADNPASIIAVGAVMPALGIIAVGLRYYCRIQLKSGFRTDDWILIPALLLTIGMGASLIAGVKLHALGYPTPFTGDPNDPLAALTQTNSGIRITSQVEWALQLMQVLELGCIKLSFAFFYRRIFVSPASKYFNVITWATIALILAWMTAFFFSLLLACKAYSGEWSAWWGSVIDLTTKCVKTEKLETALVVTDFLTDVLIMLLPIPKIWALHLPFARKLAVFAVFALGIVAVAASVVRMKYFLDVIAKGFNPHDDEDLAITRNLYWSMVESGLGLLAVCLPTLRSLLRGTTPEWLKSSEWISNIRSKLSLSSGSKSNSSKTTLPTTEREGPYRFMDGVSADSLKQERFVLKDVVTTVKATRSDRTSHGSDGDEQVLFTSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNK1</accession>
    <name>A0A194XNK1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Charged multivesicular body protein 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_637632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076086.1">
        <property type="nucleotide sequence ID" value="XM_018211539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNK1"/>
    <dbReference type="FunCoup" id="A0A194XNK1">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNK1"/>
    <dbReference type="GeneID" id="28821265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637632"/>
    <dbReference type="InParanoid" id="A0A194XNK1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25269" checksum="E302B951D3A30C4E" modified="2016-10-05" version="1">MNIVEWAFGKRMTPAERLRKHQRSLEKTQRELDRERVKLENQEKKLIQEIKKSAKAGQMGACKIQAKDLVRTRRYIEKFYSMRTQLQAISLRIQTVRTNEQMMQAMKGATGVLGSMNRSMNLPALQRIAMEFERENDIMDQRQEMMDDAIDDVTGLEDEAEGEEVVEQVLEEIGVDLKNSMGETPSGLQNNAVAEGRVAQAIGGGGADPGDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNY0</accession>
    <name>A0A194XNY0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_637897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076226.1">
        <property type="nucleotide sequence ID" value="XM_018211552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNY0"/>
    <dbReference type="GeneID" id="28821278"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637897"/>
    <dbReference type="InParanoid" id="A0A194XNY0"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="653" mass="72768" checksum="B41C19BE192F9C1F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNY1</accession>
    <name>A0A194XNY1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_694353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076248.1">
        <property type="nucleotide sequence ID" value="XM_018216699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNY1"/>
    <dbReference type="FunCoup" id="A0A194XNY1">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNY1"/>
    <dbReference type="GeneID" id="28826425"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694353"/>
    <dbReference type="InParanoid" id="A0A194XNY1"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ21893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="26887" checksum="2EAF0A4D557A13F4" modified="2016-10-05" version="1">MARQFFVGGNFKMNGSVETIKKIIGYLNEAKLDPKTEVVIAPPALYLLLAREHLKPGLEVAAQNVFDKPNGAFTGEISVDQLKDSNITWTLLGHSERRVILQEDDVFVASKTKAALDGGIGVIFCCGESLEQRESGKTIDVVTSQLKAVKDKVADWSKIVIAYEPIWAIGTGKVASTEQAQEVHAAIRGWLKKEVSEKVAEETRIIYGGSVSEKNCKDLSKQTDIDGFLVGGASLKPAFVDIINSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPG9</accession>
    <name>A0A194XPG9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_704508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075987.1">
        <property type="nucleotide sequence ID" value="XM_018217387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPG9"/>
    <dbReference type="STRING" id="149040.A0A194XPG9"/>
    <dbReference type="GeneID" id="28827113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704508"/>
    <dbReference type="InParanoid" id="A0A194XPG9"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="449" mass="49093" checksum="D75A8BFF3CC449BC" modified="2016-10-05" version="1">MLDPRLHSIWIKFFRGSAGISTGRISCPGKLRGIEYRASLIKTCLFQSIVILWRELGAICGADNPRATCIARPQPNSTDDTPVILDAFKQCGQGGNIIFPNKTYHINTVMNTIGLKDCQIDLYGTMLWGTNITYWLANSLPLGYQNQSSAWFLGGTNLTFRGHGHGTLDGNGQTWYDFVNGVSNYPGRPHALTIWNTTDSVLSGLRFVQSQMWTMTIIHSQHVLLEDIYVNSTSHTHSPARNTDGADTMFSSHITFSRWTVANGDDSISLKANSTDISIKDSVFYKGLGVAIGSIGQYKDVFELIENVYVGNVTCVDTAYAAYVKTWTGEQAGYPPNGGGGGLGYARNVTFTNFHMRNSTKKGVFYITQCTTFSGVAGDCNSSLFNVRDVRFENATGLVGTDYVADLQCSAASPGEGIEIKGVDLRDEDDEVVGMYECENVVDTVGFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ91</accession>
    <name>A0A194XQ91_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_681272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076267.1">
        <property type="nucleotide sequence ID" value="XM_018214250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ91"/>
    <dbReference type="FunCoup" id="A0A194XQ91">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQ91"/>
    <dbReference type="GeneID" id="28823976"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681272"/>
    <dbReference type="InParanoid" id="A0A194XQ91"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="71"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="300" mass="33991" checksum="A5D7F3D4DC94EBD0" modified="2016-10-05" version="1">MSSYLAKQQAAFKSDAMSAAPKVATKRNLAPPAPESAPSPAPSNASNASKSESKDPKRKREVQNVVYSQPAATGYGMEAFTQVTYVIEFLKKKNEPKTFREILEYLSQVNADERQKRLIARILLQHERVYHTPDPNLKVQSWDSGTFEHKPIINVRTKKDLIAYLQTKADAQGVSVKDLKDGWPDCEDAIDQLEAEHKILVTRTKKDNHARMVWGNDPTLHHDVDSEFQVMWHEIELPSVDELVRKLQDAGQKPASEDPSKRIKAAPKPKEKKKRAPRRGGKTTNTHMAHLLKDFSHMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR53</accession>
    <name>A0A194XR53_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076986.1">
        <property type="nucleotide sequence ID" value="XM_018214134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR53"/>
    <dbReference type="GeneID" id="28823860"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680761"/>
    <dbReference type="InParanoid" id="A0A194XR53"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="33140" checksum="B1D31BA94EAD7284" modified="2016-10-05" version="1">MASSKSEIEKLGFAGLPALAPDLGHEIVTILVGSERKKFTVHKRLLCASATMFRGAFSGQFLESQEGTMTLEEDSPAVFALYVEWLYRSSVSVISTDPHAHLRDLYGLYFFADKLLLPALKDKTMDAIQDVSLKHGILQSICTPEMIQKVWANTSASENREERGLRAFVIHAATYVLVKRAEVDPDDEADSEDDLYEKMEVRKQLVCPNKADLQWMWELSKGSFEIYRQFIYRIDWKSSLIGDPRKRYHNNPRSVHRFHCSKKGFNAEQQEDMRLSRRLAAATLSQGTEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR94</accession>
    <name>A0A194XR94_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_607272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076929.1">
        <property type="nucleotide sequence ID" value="XM_018210450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR94"/>
    <dbReference type="FunCoup" id="A0A194XR94">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XR94"/>
    <dbReference type="GeneID" id="28820176"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_607272"/>
    <dbReference type="InParanoid" id="A0A194XR94"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="35211" checksum="E5B4F9AB69ED63D0" modified="2016-10-05" version="1">MATFVMQSLGCEVAALNTVQFSNHLGYGQAKGTRATAQEITDLYQGLKDSYLDDFQMMLSGYLPGAASVEAVGTIGRDLKYKATMKPGSFFWVLDPVMGDNGKLYVAEDVVPAYKGLVKDADLILPNQFEAETLSGVKIVDMDSLKEAITTLHGKYRIPHILITSIAFPTHGATPSLSVVGSTFTTGAKPRIFGIKIPAIDCFFSGTGDMFAALMLVRFREAVTNVPGLMATAAWVSGDEVEATELPLAKATEKVLASMHEVLTKTKESRDAELERYSKQVGGRDAMSDEKKLRLVKSKAAEVRLVRNLKALKDPDVKFRAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSH3</accession>
    <name>A0A194XSH3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_163523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077344.1">
        <property type="nucleotide sequence ID" value="XM_018205515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSH3"/>
    <dbReference type="STRING" id="149040.A0A194XSH3"/>
    <dbReference type="GeneID" id="28815241"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_163523"/>
    <dbReference type="InParanoid" id="A0A194XSH3"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="525" mass="55822" checksum="AF3658F409CF32D6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT80</accession>
    <name>A0A194XT80_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_728163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077768.1">
        <property type="nucleotide sequence ID" value="XM_018219239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT80"/>
    <dbReference type="GeneID" id="28828965"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728163"/>
    <dbReference type="InParanoid" id="A0A194XT80"/>
    <dbReference type="OrthoDB" id="3455587at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="757" mass="85274" checksum="C6B64456CEB9034A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTP1</accession>
    <name>A0A194XTP1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_680308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077933.1">
        <property type="nucleotide sequence ID" value="XM_018214049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTP1"/>
    <dbReference type="STRING" id="149040.A0A194XTP1"/>
    <dbReference type="GeneID" id="28823775"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680308"/>
    <dbReference type="InParanoid" id="A0A194XTP1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="507" mass="58103" checksum="B0F021A59650663B" modified="2016-10-05" version="1">MYSLQVRTRRVKCDENKPTCYRCQEYGAFCEYKSPQPRAAAPEPTPPQKRCRGLVPIQPRPLQLVPSPSDPFPMDEVEGRYFRLFHEKLAFDLSGYFEAPFWTRVIPQQCHHEPTIKQAVLALSALYKSAISSETSTVNVDDEHVKFALVKHSEAISSLRKALSSGKPQMRLALIASLLFSCFESFHGNWETATQQVYSGLNILKHLSEDERQHATDSLNDIYLEVGLTLRRLEMQILSFLAMNPILEHPFDDLYVEEIILDIPDRFTTFNEAFTALTYLAVSILRHSRASARCGDEPGPRNSIAQQQLHLQGSMDRWNRAFEPFFLEKCQNTVGREYLGLLQVRICAWKLETMIATSTSHTEIVFDGFIAQFQRITHFARYLFRKDQEIRESDGSILQYGMGLIMALFYTATRCRDFTVRREAIAILREWPCTNGIWHSLQAAKVAEWIASIEEDYCCGLEVIPENCRVQMHSLKVSLQKGVITVECVQSSVDGVLQSRRANLEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTW1</accession>
    <name>A0A194XTW1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_573887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077931.1">
        <property type="nucleotide sequence ID" value="XM_018208707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTW1"/>
    <dbReference type="GeneID" id="28818433"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_573887"/>
    <dbReference type="InParanoid" id="A0A194XTW1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27458" checksum="C9CDA2B01F876475" modified="2016-10-05" version="1">MADISEKALDKASTKLKQLVPSAHRVEIKVCDVSKETDVKAMVEHLDSWGGVDIIFNNAGIMHADDDDAINTPEKIWDLTQAINVKGVWFGCKHAILSLRKFNKAKGSIINTASVVALVGSATPQLAYTASKGAVLALTRELAIVHAREGYRFNALCPAPLNTPLLQDWLGDDKPKRLRREIHFPSGRFGEAIEQAQAVLFLASDESSFINGQDFVVDGGMTKAYVTPEGPPLAAPKNNALLSEQVDAIRGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU09</accession>
    <name>A0A194XU09_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_574374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077547.1">
        <property type="nucleotide sequence ID" value="XM_018208740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU09"/>
    <dbReference type="FunCoup" id="A0A194XU09">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XU09"/>
    <dbReference type="GeneID" id="28818466"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574374"/>
    <dbReference type="InParanoid" id="A0A194XU09"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="25767" checksum="2453E90BA101372D" modified="2016-10-05" version="1">METLKAMFVKPDPQTQVRKCNQLIRQNTRKLDRDIANMKLAENKARTLIIQTNRRAQRNPAQAKQAEKDIRIFARELVRTRRQHNRLVTSKAQLNSVSMQVTEAFAVRKIEGSIRSSVGIMKDVNSLVRLPELTGTMRELSQELVKAGIIEEMVGDSLPDELEEEDEEAESEVDKVLGEILSDKMSKVGATPTTPTPVQQEPVAEDEDEEDAEAMLDQMRGRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV02</accession>
    <name>A0A194XV02_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-type transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_728274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077892.1">
        <property type="nucleotide sequence ID" value="XM_018219252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV02"/>
    <dbReference type="STRING" id="149040.A0A194XV02"/>
    <dbReference type="GeneID" id="28828978"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728274"/>
    <dbReference type="InParanoid" id="A0A194XV02"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24304" checksum="028C8659E639B182" modified="2016-10-05" version="1">MADITDQHDQGSPSALDEHAVGNGNSIESRGVKRQRPSTADDDDDDDDKPGRERRKIEIKFITDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKAEGKNLIQACLNAPEPPSNGENGVDDQNTADSPEEPTPQHLPQQNRMPQQPQNMHGGYMPPTLEQQRQAMAYQNYVAQQQGTGGYPMPPQAGIPQQHSHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV73</accession>
    <name>A0A194XV73_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_727262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078585.1">
        <property type="nucleotide sequence ID" value="XM_018219134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV73"/>
    <dbReference type="GeneID" id="28828860"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727262"/>
    <dbReference type="InParanoid" id="A0A194XV73"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="29992" checksum="07917587328F665F" modified="2016-10-05" version="1">MDPDTYDAYVRYADMWIEDLRALCRSLGVDSHGNQAELIQGILEHDARMQMEASRNMDERLPSGRPTNEEIPLHFDHTATRYRTQIHSTFDDAEVGDKLIGPRSASRYIEKMEEKEQEEYKREMRELSDDLGEMLGYSAKTGEREVSKSENENSVPSINKQNEEVRTPKAQRLIRDPSSDILFPEGKAPTMSPFDEFAAMEKEKKKPMNMKIQMPDKTVDISGQAATQATDQKECLRFSLVDLQSEITTPPDGHGEKVSPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVX1</accession>
    <name>A0A194XVX1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_703179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="24519" checksum="FD69901AF6A59EC4" modified="2016-10-05" version="1">MVLKRKRSDSDMSSASSLLSSPLSSKIMPIDQFQSYPNRIPTPSLFPSRTRKRHRDNRPSEAEVHQHTLSLLFSAQQSPQPELQPPSAFPSQEPISSLPTTSQSRQQSSLHSFWAIPSTRQSSPSSNSSTSAPYAPAPASSLSNVFEVSNCEDCNAALNPTGDSDAMDVDMMMDIDMNGGNHACTSCGKQVCHSCAVSNLGAERKCLNCAGRKQVWVGGLGWMDQE</sequence>
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        </source>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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    </evidence>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="4 5">CBS 120377</strain>
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</entry>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="28830706"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743770"/>
    <dbReference type="InParanoid" id="A0A132B297"/>
    <dbReference type="OrthoDB" id="3552322at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="20058" checksum="B96055BE87B09CFB" modified="2016-05-11" version="1">MRVVNDQESGLVPETMADARSRALKLTILVAILRTVQLTLGLNILFLTGVGASVFQGDFIFIRSRWFPKSNFNWCHRFVTFSRVPHPILTNFTGVLEIITLIFWLSTFSLLVWECMDGDQTFAVPGDSGEQQLVTYVSASNLKSAIKGLKAATGLACINWIAFAVIPTQYDRKGITAAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2X4</accession>
    <name>A0A132B2X4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_536991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061101.1">
        <property type="nucleotide sequence ID" value="XM_018208113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2X4"/>
    <dbReference type="STRING" id="149040.A0A132B2X4"/>
    <dbReference type="GeneID" id="28817839"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_536991"/>
    <dbReference type="InParanoid" id="A0A132B2X4"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="38435" checksum="559439353BDA31D8" modified="2016-05-11" version="1" fragment="single">TLAVLGLATLGRSHMIMNTPVPYGKSTLNNSPLAADGSDFPCKQRTGVYDAEGASNSMALGSSQSLAFTGSATHGGGSCQVSITYDQAPTTSSTWKVIHSIEGGCPIKGVAGNNGDSASAVDPDTYSFTIPTSLPTGTATLAWTWFNKIGNREMYMNCAPVTLTASSSKRSDEDELMERNYTMLMERDTAAYNALPNMFTANIGNGCGTVDSTDLKFPAPGDSVEQDGTATATPVAPTGTACGSTVAGASATAGSSGSSATSAAVSQASSAVVASSSPSATGGVFATVASSQATSAPAASSTPVASVASSAIAFTPVASSAAPASTGSSSSTTGTGSAIAAGTACTTEGEWNCIGGTSYQQCASGTWSVVMELAAGTSCTAGESTNINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3X3</accession>
    <name>A0A132B3X3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_743093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061447.1">
        <property type="nucleotide sequence ID" value="XM_018220919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3X3"/>
    <dbReference type="FunCoup" id="A0A132B3X3">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B3X3"/>
    <dbReference type="GeneID" id="28830645"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743093"/>
    <dbReference type="InParanoid" id="A0A132B3X3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="438"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ07092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="55096" checksum="77DC571A96ADA601" modified="2016-05-11" version="1">MPTLGFLKKKRTKESPGQKDLASPTSTSSQATSPVTPTSSRGFENSITTVSTHSTTHSTTPQTQSTSQPSASAQQEAPTAVGEQQPMTTQGVSYQQQAYAPSQYQDIKSATNADHQNLPTINNLINPPQTDGATQSKADQTPSDASNGQARQPESQQLKPAQAMPQITQVRQTKGKYSLGDFEILRTLGTGSFGRVHLVQSKHNSRFYAVKVLKKAQVVKMKQVEHTNDERRMLQEVKHPFLITLWGTFQDSKNLYMVMDFVEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHGKDIIYRDLKPENLLLDRHGHLKITDFGFAKKVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGFTPFWDGGSPMKIYENILKGRVKYPPYIHPDAQDLLQRLITADLTKRLGNTHGGAEGVKNHQWFAEVTWDRLAKKDIDAPYVPPVKAGVGDASQFDKYPEETESYGQHGHDEYAKLFHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4K1</accession>
    <name>A0A132B4K1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_602008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061528.1">
        <property type="nucleotide sequence ID" value="XM_018210225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4K1"/>
    <dbReference type="FunCoup" id="A0A132B4K1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B4K1"/>
    <dbReference type="GeneID" id="28819951"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602008"/>
    <dbReference type="InParanoid" id="A0A132B4K1"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="206" mass="22777" checksum="2867DFE598070ED8" modified="2016-05-11" version="1">MAAPAISSQALLTLMKNRRTYYALSKSSPIPNDKITAIVQDVLKHSPSSFNSQSTRVVVLFGGEHDKLWGFAKEAIKAIVPADAWPASEQRLNGFLGGYGTVLFFDDRTTVAGMQQKFALYADKFPVWASQSNGMTQYAVWTALEAEGLGANLQHYNPLIDQKVAEEWGLSKDWELSAQLVFGKREGEPGEKTFMPIEERVKVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B512</accession>
    <name>A0A132B512_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_766122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061847.1">
        <property type="nucleotide sequence ID" value="XM_018221711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B512"/>
    <dbReference type="GeneID" id="28831437"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_766122"/>
    <dbReference type="InParanoid" id="A0A132B512"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="71"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="42295" checksum="90DAE9C211A03008" modified="2016-05-11" version="1">MEEPQFISTSLRNESYENVTIYPPGQRVEINTGFYGPQILSNNKAISKIERKDTLCLGGIIQVVNTMLQVPINLGIQLFEQANLNYFVAILNQINLLALNNTDLADFIYDLTTTPNLTFFCPNSATSLASFNNLSQSLSANELLDLFNYHVVYDFVGYSSVLTNGSTAKTAQGKDIIFTRDAEDNIYVNQVPITTVDYLAANGVFHVVDGILDPNNVTIPPQIPRAAASTSSPASPHNGLSTNGIVAISVVVPVAALAVLAYILFWFVRKKRKEKKMTADSQGPDPSISGKTAGELSSDSALRELDGDDAKKELGAVRPMSELDAAAKPVEFPSPPPAIELDATPKREHDHLLGEEGHGTPLTAVVVSPMTDVDVPIREGETTAMNGDATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5L3</accession>
    <name>A0A132B5L3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_765652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062061.1">
        <property type="nucleotide sequence ID" value="XM_018221685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5L3"/>
    <dbReference type="GeneID" id="28831411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765652"/>
    <dbReference type="InParanoid" id="A0A132B5L3"/>
    <dbReference type="OrthoDB" id="3557106at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="33345" checksum="EF7C346E002AA869" modified="2016-05-11" version="1">MLAQQGVCIWAIVNGMGNREVDMTMKELLLQARVLVAVSTTWIFSTTVIKLAVLALYLRIFTTPGFRRWAVSLMVIDVCFGITFLVVFITHCNPVSQQWDPVPWGSCRSLTSSELSSISLNLVLDTAIVVLPMPWLWNLRMALSHKLVVMVMFGFGFATIAIMCYRLDQTVHSDPDPMIATARIGLLSNLELWLGIIVTCLPTMAPFFRTNLLPGLSKLSRKLYGSSAPSSKEETPRVQLRTFGGSGPPVSKDNKNYTELLRVQQYGSVAKQRWNSCTKAIPDNGYVTRSRSYCAFVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5M2</accession>
    <name>A0A132B5M2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_360457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061996.1">
        <property type="nucleotide sequence ID" value="XM_018206992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5M2"/>
    <dbReference type="GeneID" id="28816718"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_360457"/>
    <dbReference type="InParanoid" id="A0A132B5M2"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287878" evidence="1">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="20678" checksum="7FE9E4454949F69D" modified="2016-05-11" version="1">MKSSTIVAILSFSVASLAAPTTYTTPTRSSHFGKRSEQDAINDCQNTGNPSLCEQVVTAVSSWDTSVNMVNMFLNDAETSSGETLIDLENMALAFANLEPGFLSTLVGTPNISPDGVSAANTLMQVFSAVPGNLTLLINGDQSVSSTVDNINNVRCAQILGNIGELWQQAAAAAGADVPGTPLGPNFCPKSGGNSGDAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5U8</accession>
    <name>A0A132B5U8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_677562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062135.1">
        <property type="nucleotide sequence ID" value="XM_018213686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5U8"/>
    <dbReference type="GeneID" id="28823412"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677562"/>
    <dbReference type="InParanoid" id="A0A132B5U8"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287910" evidence="2">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="17856" checksum="21A2048A9F980BBE" modified="2016-05-11" version="1">MKSSAVILALLSVATASFFAPRADTTSSVDPTTTTYSISPTASCLAACKPGDVNCQAACVGSAHPNSVQVNQTNVCADNCPKGDGSTSANNAYEACLDSCIQSYYPTSQTAAPVSVGSGSVTSVSAGATGTAGQATGSGSATTSTSASGTGSVAATSSSKAAGANNLPYIASAGGFGGLLLAFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5X6</accession>
    <name>A0A132B5X6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_725553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062170.1">
        <property type="nucleotide sequence ID" value="XM_018218984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5X6"/>
    <dbReference type="GeneID" id="28828710"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725553"/>
    <dbReference type="InParanoid" id="A0A132B5X6"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32710" checksum="9D14CD189E2995B1" modified="2016-05-11" version="1">MSFANGSAEIKGPGWTEAWASIMEVLYCSPASLGRHHRFIPLRPTFPPHTQHLLAPQEVLAFPLYPPLEGNLRLATAAADLPRIADLSVLGFRDSEIFRFERPRYQEFPQDAVAAFSNIYRTQLLDPLAIVVVVEDLRLPEDETGATRQTERVVVGVASWDLPEDSPRKGRASSSCLMWMTPYLSLIAISANVDGSSLLDLVRLQRRRNSICDKLVVHPLYQRRGHATSMLQWFLVLSRHDKIDAGVIPSHMGELLYLALGYEKIDEVPVPDDGDTQGFSQRVLLFHATANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5X7</accession>
    <name>A0A132B5X7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_600948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062165.1">
        <property type="nucleotide sequence ID" value="XM_018210173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5X7"/>
    <dbReference type="GeneID" id="28819899"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600948"/>
    <dbReference type="InParanoid" id="A0A132B5X7"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20278" checksum="A5DA40D355BEAE0B" modified="2016-05-11" version="1">MNINQSLIARHPSLTQEEFCEYWYTKHAPLVVPMFLYSGTQHYEQALLETDLSLQIHGPLTYTTPSASSDLEIQLHHFSGAAAILRRQPSSDNPSPTPKWVQDYYTEVVVIDERKFLVSEAANHYVRVPPETVNGDKKVIIQDGKCLIEVGDEVWKVWREYEARGGMEVEESKARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B792</accession>
    <name>A0A132B792_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_789096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062631.1">
        <property type="nucleotide sequence ID" value="XM_018223220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B792"/>
    <dbReference type="GeneID" id="28832946"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789096"/>
    <dbReference type="InParanoid" id="A0A132B792"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287937" evidence="1">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23458" checksum="711BF4A5314076B2" modified="2016-05-11" version="1">MTSMLIALLTAPALLATQEAITQGQKKDRREEHRARRSALIVSCVDASPLSLEIDHRQVALKNSKLFIKTDPCDTSLHPFGGYYLPYPDAGYEGLVSTITDVAPVLNWIYVDKETYEVKYGVKADAHPNITGPFNCTRQDKRLTLEEWEGFVAVKVEEGENAGMWELYYDKDDDLLAGKLGSGRKILEVELVRWEKKVRKGKPLGDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7A4</accession>
    <name>A0A132B7A4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_765587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ08123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062478.1">
        <property type="nucleotide sequence ID" value="XM_018221679.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B7A4"/>
    <dbReference type="GeneID" id="28831405"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765587"/>
    <dbReference type="InParanoid" id="A0A132B7A4"/>
    <dbReference type="OrthoDB" id="4838614at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1060" mass="120867" checksum="F259ADEC035E2777" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7L3</accession>
    <name>A0A132B7L3_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_702272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28826970"/>
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    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287932" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="252" mass="26829" checksum="36444DC07EADB1B1" modified="2016-05-11" version="1">MFTSTVLSLFSAASLVAAAVIPDLTLARRNLTENEVIVWGSNGRVEVMNKSEFALLASESSQSFNLTSSTPVLLNNTAFNHSLSSRALSSRSCSSDSYFTMNPASTFLNWDVPMSSVLHATSPSTSVSVTEGYTISNTIQIGVSSTLTIVESFLSTTFSINYSESWSSSYSAAYTFAIPEGKYGVVVSNSMTTRHSGYVDVGCIGSTERTYFQADSYNSKAYGGLSWVDGTISLCTGDTYPVPMCLGGGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B807</accession>
    <name>A0A132B807_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_764479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ08383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B807"/>
    <dbReference type="STRING" id="149040.A0A132B807"/>
    <dbReference type="GeneID" id="28831361"/>
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    <dbReference type="InParanoid" id="A0A132B807"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="28947" checksum="A2F1A1248E85860C" modified="2016-05-11" version="1">MLTTYTILGGTGATGSELISYLLNRQPFVHLNIYVRSSSKLYTLFPDLQTSPNITIFTGSIDETPVLASCIRSATAIFCTIAQNKNEPDCSLSQRTAHAVILALTQLRSESAHPATYTAPPLVWPSSAALNPAFEKRIPAALRAVALRAAFHVLQDLRLAAEYLGGFEWSPVSFWQPRPIVKDEARGVSLTAEKRFDLISYADVARGIVKIVEEGDGMWIGKEVGFVALGGKKVKNLPPSTFIWILAGLLGYCVPSLWLAGRKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA29</accession>
    <name>A0A132BA29_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_711145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063617.1">
        <property type="nucleotide sequence ID" value="XM_018217884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA29"/>
    <dbReference type="GeneID" id="28827610"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711145"/>
    <dbReference type="InParanoid" id="A0A132BA29"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="46800" checksum="69733DBE80531E16" modified="2016-05-11" version="1">MGKKLNIVVCGAGLAGLGAAIALRRKGHDVNVLESTSELTEVGAGIQIPPNSSRILISWGLEDKFAEKVVWPGRMQMRRYATGEILRLQEVNPFMSDTYGYPYWLIHRADYQKILYDAAKEAGVHFSLGCHVESVDEHGPAIFLRDGRQLEADLIVGADGIRSKIRKSILGNNDPGPEDSPNCAYRATIPADVMNSDPALATLMSDPNGNLWTGPGGHVMAYPIKNATLYNLVMSHPGKASIGKKIHEKWDKVLQKVLTHVDHCLKWKLAYIPPLNTWVSESGKVVIIGDAAHGMLPYMAQGAAVSIEDAAALAEAVSRARSNDDLLHLLKAFETVRKPRCEDISRSKHVNAVVWHLPDGPEQEKGDATSKAKMRKKLEKDKEAGITGGMEGKWNDEATMPGLFGYDAVKEMNVYLDSFASSHDTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAR6</accession>
    <name>A0A132BAR6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_288737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063836.1">
        <property type="nucleotide sequence ID" value="XM_018206506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAR6"/>
    <dbReference type="GeneID" id="28816232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_288737"/>
    <dbReference type="InParanoid" id="A0A132BAR6"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49066" checksum="DEBCF7D0E0FE5901" modified="2016-05-11" version="1">MVHYLHKALFGINTISEFCSLQAFRSNPHLQVEMTSTNGTGIVHPLATLTAAARATVERQILDPIPASVEKYWNTCRDELSVTWDRKNLADPVQQYTYTQLYDLDRTKKFDPSKIVDVDLNQIAVRKPEYAFNWNDFGTIINSRTRPDTIATQSDGDKEAMRNTISIPLTEAYIRLVCDYANGVRDKAERAVGSTAPPRISCHCMLQSSWQPLRDAALARDPYATIAQQILTQQGITQQTFAEMDFLFLPHLRPDLDDAGGEHYTLLGFAPRQKYAFWINSAEPKTPSDDPDVDLPIQEYEAYMRDSLLAILFCLVPDHDERESWEVNLDYCGNEDKTLRKAVRQRDTYNCGAYVCTNALLLAFGYNLTSFDARDIDQFRKPRMFAELLNGGFSGLYQYDLIEFPAPRTDTDPSPSYDEAIEAREDWETGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC73</accession>
    <name>A0A132BC73_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064323.1">
        <property type="nucleotide sequence ID" value="XM_018215984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC73"/>
    <dbReference type="GeneID" id="28825710"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689855"/>
    <dbReference type="InParanoid" id="A0A132BC73"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="57" mass="6463" checksum="018DF145BC43BF8E" modified="2016-05-11" version="1">MLGDFPQLFEAVQANSYEHVSEKNESSRCLYMFGDKSKGSDVISGKSLAYVMPDLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCD7</accession>
    <name>A0A132BCD7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_675551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064411.1">
        <property type="nucleotide sequence ID" value="XM_018213520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCD7"/>
    <dbReference type="STRING" id="149040.A0A132BCD7"/>
    <dbReference type="GeneID" id="28823246"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675551"/>
    <dbReference type="InParanoid" id="A0A132BCD7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="43544" checksum="8836B286E057DD07" modified="2016-05-11" version="1">MPGLTWTRGNVYSVNSTTPSRLTGSMISTTRPQTLVNSTGFYETVTPPTYAEYDVSQVIDVKDVAAHPVAGDGVTDDTASLQAILNSAAGKQLLYFPHGIYLLTDTLLIPVGSRLVGESFTEFSASGSKFKNAKQPTPMLKIGNAGDVGVAQLTDFIFTVADILPGAVLVEVNMAGGKPGNQSRDLHCCTNLCPLDIYFLVILGNSWAWVADHDLDGSSTQTPSPGGGFLVEAQRGTWLLGLGIEHHTLYQMNIVGAKNVFLGLQQGEAAYWQGAGATVLAPAPWTDSLLPSEPPDWSWCAATDAVCRMGLYQRVSNSSIINISSGGFWNFVSGPSRTFCATDCQDNAALYESSSKVFTYGISTINSKTLILESGVGGDKDVAEVVRTANSGAAHDGFPTGIMAAYLRMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCT8</accession>
    <name>A0A132BCT8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_689990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064536.1">
        <property type="nucleotide sequence ID" value="XM_018216010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCT8"/>
    <dbReference type="STRING" id="149040.A0A132BCT8"/>
    <dbReference type="GeneID" id="28825736"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689990"/>
    <dbReference type="InParanoid" id="A0A132BCT8"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="288"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ10181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="556" mass="61498" checksum="3B8354C1C158B9C1" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCV4</accession>
    <name>A0A132BCV4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_255565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064615.1">
        <property type="nucleotide sequence ID" value="XM_018206233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCV4"/>
    <dbReference type="GeneID" id="28815959"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_255565"/>
    <dbReference type="InParanoid" id="A0A132BCV4"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF1">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288146" description="cutinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="61"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="25376" checksum="C488CE3B695760E6" modified="2016-05-11" version="1">MHRLLVLFHLISFVSAGILDDIGSSLGSLLGNNTASVLGTFLGDHGTVIFQNGLLKNTTACPAMSVIFARGTAEPGNVGILTGPPFFAAIAEYMNGTNQLAIQGVDYPADVPGFLAGGSTQGANTMAKLVNKTLASCPNTQLLLSGYSQGAQVVHLATASLPSNTTSKISSVVLFGDPKNGTAVSGVDASKVMTFCNPGDDICQGGDLITLSHLNYSLDAGSAAMFALGTSGAKLGITSQRLRPAAGGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD26</accession>
    <name>A0A132BD26_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_723577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064687.1">
        <property type="nucleotide sequence ID" value="XM_018218829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD26"/>
    <dbReference type="GeneID" id="28828555"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723577"/>
    <dbReference type="InParanoid" id="A0A132BD26"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF165">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="380" mass="42589" checksum="F1DCEC8C63AC9EF0" modified="2016-05-11" version="1">MLSPHVSGLGPAVLATTWSEFAAGTVLMSMRIYVNAFIIRRWSADFWWALITYICSVLATIFLTISVEFGLGSHLTDLLALDSELIVRNQFHQWIFTTFAIVSIALGKLAIIALILQIEGTSTTAHKRKWVLWAFVASNVIVNIIIIPIVWTQCSPTAKMWDNSLEGDCNGRERNKLYGFFQGSFGAFLDVALAIYPVIIFWNLKLRLHIKIGLMVLFGFGIMASVCAVVKTVELSTLTATSDLTFELANLNIWASTEMWVVFIVGCIPTTRPLFVKVLDVVVSSGNRTFRTGRGYTEQDNSNTNTSRSRAYSESRKNPSKITTIVSKNESEENILPGQEGIMMTRDIRVQYQRNDPEAGSFDKASKDPDNWKTRFDDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDU8</accession>
    <name>A0A132BDU8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064941.1">
        <property type="nucleotide sequence ID" value="XM_018215969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDU8"/>
    <dbReference type="GeneID" id="28825695"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689776"/>
    <dbReference type="InParanoid" id="A0A132BDU8"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="82" mass="9351" checksum="428C6F70FD39D8FD" modified="2016-05-11" version="1" fragment="single">MHASFAVPKTAESEPELFLMLEIMDEIFTEAHSWCFDGPDCMLTWPRQLALSRFHTAAASGQKLRAFDPKKEPNTLKTNFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEV5</accession>
    <name>A0A132BEV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064749.1">
        <property type="nucleotide sequence ID" value="XM_018220550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEV5"/>
    <dbReference type="GeneID" id="28830276"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740111"/>
    <dbReference type="InParanoid" id="A0A132BEV5"/>
    <dbReference type="OrthoDB" id="3532374at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288202" evidence="1">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="25002" checksum="650EBE03AF8A4760" modified="2016-05-11" version="1">MNPLNFLACLAAFLTFTVLSTANPLNVRTGGVLTVAKDGPPAGYTFGKLTYHTHCHAQVKAQYPEFQLPVHNATKFNELKAAATKAHTTLATASGVDRRSPVFGGDGWHAYCNPVPGQPWLLANEMNLDYTLYFWQGVISEYYTINGMTCALWDCNLGAGWTVCNGGGDTQTLTEDSMTYYPFILINSCGSFFKDFKPANGGQIFWESANLNYIAAGNWNGCWGETFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRN0</accession>
    <name>A0A194WRN0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_248016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065010.1">
        <property type="nucleotide sequence ID" value="XM_018206162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRN0"/>
    <dbReference type="STRING" id="149040.A0A194WRN0"/>
    <dbReference type="GeneID" id="28815888"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_248016"/>
    <dbReference type="InParanoid" id="A0A194WRN0"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="46578" checksum="4922BDB5B2C80652" modified="2016-10-05" version="1">MPKDTRRSPPRTFLPPTKPMKTERTHEENQERAYVAASRRSDRSLEARVESAHRASEIHKKRTGRGFKITVEGVANEEMYEEEDDLPPKYRNVTHHFPMDRNGEFNERLGAYLASNVALRTLVAQSMEASEQHPSGFAANHSQIPNQGPAQMQMHMQQTNHNQNMYQAQHGAMYRHQPYPAARPVRPQSFTSVSHNRSASFQATEPFKPSDHRRMSMPAAVPSAAGSPMQVPTPNSIHSVNSTPPQKPATFSRQSSGYGQQPPTPQQSQFQPPPPPAFSTDPYHPNYSPFTAQLPANAQGLLGSTLDLNNPHHQLMMAGSGNLASSYYDFGPQSQSQPQPNFNTSVGQQTHPTLDGLSSTLAQSALDMQFDADNGQPQSFFNDAYTENLVETPGETLDWNKYLTSDYFDCPGGSQNSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSK8</accession>
    <name>A0A194WSK8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_689321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065024.1">
        <property type="nucleotide sequence ID" value="XM_018215886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSK8"/>
    <dbReference type="FunCoup" id="A0A194WSK8">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WSK8"/>
    <dbReference type="GeneID" id="28825612"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689321"/>
    <dbReference type="InParanoid" id="A0A194WSK8"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120019">
        <property type="term" value="F:phosphatidylcholine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031322">
        <property type="term" value="P:ascospore-type prospore-specific spindle pole body remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="104"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="341" mass="38518" checksum="A0F5B5052FBCF591" modified="2016-10-05" version="1">MASAEKGMKLDPKYDHYDFPTISPNTLSGHPGHTTPEQDAQVHQLRMKLEAAGYTDRLDTLTLLRFLRARKFDVALSEKMFVDCEKWRKDTDLDNLVRTWDYKEKPEVFKYYPQYYHKTDKDGRPVYIEQLGNIDLAAMYKITTSERMLNNLAVEYERLADPRLPACSRKSGTLLETCCTIMDLKGVGITKVSSVYSYVKQASAISQNYYPERLGRLYLINAPWGFSGVFNVVKGWLDPVTVEKIHVLGSGYQKELLSQVPAENLPKMFGGSCECDGGCGFSDAGPWTDPEWTKPAKWQREDNVIDNTATNPGTIPDGSAQKPVEMQGDEIKPAPALHQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT92</accession>
    <name>A0A194WT92_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_654901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065521.1">
        <property type="nucleotide sequence ID" value="XM_018212320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT92"/>
    <dbReference type="STRING" id="149040.A0A194WT92"/>
    <dbReference type="GeneID" id="28822046"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654901"/>
    <dbReference type="InParanoid" id="A0A194WT92"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="332"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="44130" checksum="89E54C695E0A1A62" modified="2016-10-05" version="1">MHLIEHKDTTRDTRFKPRIGHVLYRIPGIMWSSGLCWRSRHRPCKAIFHQRHSTRELFVTRRYSSSSIDEVTDDDRRRIYIHGSGNKGCFMAFCLATKPNPPPITLLVANRERIKAFEEEGKKIRIYTDGKWFESGGVDIELLEMRHGRAITEMSSGPASFDSISSQLRVTVTPEGREVSAKEAFGGECPPKPKASQRPIFNLITTIRSPQAARSMVEVQHRLGPDSTVIAMQDGLGVLEEVFGTCFPDPRTRPDFRLAFISHDARYQGKGLRIVWSGIGVCVIGPLADGSVSKVKGDRWRRTQHSQYLLDEVSSSPILDCREVDQRSSIVMRYRKLIIDAVIGPLATAYSCENKDLLSKPGAPEILEDLVTEAWAVMRHDVAGTYLQGVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUX9</accession>
    <name>A0A194WUX9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066115.1">
        <property type="nucleotide sequence ID" value="XM_018215808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUX9"/>
    <dbReference type="STRING" id="149040.A0A194WUX9"/>
    <dbReference type="GeneID" id="28825534"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688930"/>
    <dbReference type="InParanoid" id="A0A194WUX9"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="268" mass="28813" checksum="7C6E21C8D896DA45" modified="2016-10-05" version="1">MSLYEISPDTSINVVASGKKVSTRPTLIFLHFWGGSSRTFTNTITYLSPHFHCIAVDFPGWGSSIGPQKSEAYSIAQLAIDIETLIPKLDVEDFVLVGHSMGGKVSQHIAGRNQLSGLKAVVLLGPAPPTPFSLPPDMKQQQISAYSSHESAEFVVRNVLSSAQISDEMVSALVEDMLKGTELATKAWPAYAMAEDIATVARKITVPVLVIGGELDKVEPIQRLEEKVLANINGAEMVLIKGSGHLLPVEAPEQVASHIEAFVQKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVE7</accession>
    <name>A0A194WVE7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066295.1">
        <property type="nucleotide sequence ID" value="XM_018218722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVE7"/>
    <dbReference type="GeneID" id="28828448"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722344"/>
    <dbReference type="InParanoid" id="A0A194WVE7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267573" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23541" checksum="8E6CD2A0331573CF" modified="2016-10-05" version="1">MTFPFLLSVPFPCLLSWPSFAVSAAQARRDQGGDQGKRPSAVVLVHGKKRHAIVLFNIACNTRCRLQCQLTAILSLILSLKYSAFFSSHLVPSLARLADAAQLSLTAWLHCSMHPPSSQGQFWLAVCDPESNQVRTATPSNSLSPTTVLVHLLAKPGPTMKDHHFAFLRVAFDSHLIYFLLTSYRPCDPFCVSHCSPGSQVQSLTSNRKTHPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW06</accession>
    <name>A0A194WW06_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066506.1">
        <property type="nucleotide sequence ID" value="XM_018215739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW06"/>
    <dbReference type="GeneID" id="28825465"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688616"/>
    <dbReference type="InParanoid" id="A0A194WW06"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267514" evidence="1">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13215" checksum="6A9F4D25BA8E0425" modified="2016-10-05" version="1">MHLKTPLLCAAALLSSAISASPTPGFNGLFEYAELDQYNTTEWYLDFPPPPKNFITNTHNHSTLNEDGSGRIYHAKPYSRQCKNIDEKTTSFSYYLALFTQAWGEFLHIMLDAGDMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWH6</accession>
    <name>A0A194WWH6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_688506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066389.1">
        <property type="nucleotide sequence ID" value="XM_018215722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWH6"/>
    <dbReference type="FunCoup" id="A0A194WWH6">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWH6"/>
    <dbReference type="GeneID" id="28825448"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688506"/>
    <dbReference type="InParanoid" id="A0A194WWH6"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23428" checksum="C23102C623EF2046" modified="2016-10-05" version="1">MAPVPSDLRPVVISGPSGVGKGTLYKLLLERHPSLFATSVSHTTRSPRPGEKEGVDYYYISMAEFEKMIADNAFVENAKFGDNRYGTSKMTIENLTKSGRVVVLDIEMEGVKQIKKSSIEARFVFISPPSMSILESRLRGRGTEKEESIQKRLAQAENEMAYSKTPNAHDLIIVNDDLEKAYQDLESFIFKKRTQDQEAGDASSAGVSVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXF4</accession>
    <name>A0A194WXF4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_623876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067018.1">
        <property type="nucleotide sequence ID" value="XM_018211035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXF4"/>
    <dbReference type="STRING" id="149040.A0A194WXF4"/>
    <dbReference type="GeneID" id="28820761"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_623876"/>
    <dbReference type="InParanoid" id="A0A194WXF4"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="7">
        <location>
            <begin position="795"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121735" checksum="2B597A1D53D4EFC2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXL2</accession>
    <name>A0A194WXL2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_191240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067078.1">
        <property type="nucleotide sequence ID" value="XM_018205703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXL2"/>
    <dbReference type="GeneID" id="28815429"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_191240"/>
    <dbReference type="InParanoid" id="A0A194WXL2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267564" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14488" checksum="B8754A5955E3D224" modified="2016-10-05" version="1">MKISMLQQIVLTAVCAVVEEAVISQWVTAFRKDRETLLLIHFSSDDGRSSTTRKRRWNLAWKQSKLHAFSLYQTLSISLFSNPTNTHFTHLTSPRGTMPTPAGSTSSRAAPGRLARAAGLITKSHRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY25</accession>
    <name>A0A194WY25_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_592295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067231.1">
        <property type="nucleotide sequence ID" value="XM_018209689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY25"/>
    <dbReference type="GeneID" id="28819415"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592295"/>
    <dbReference type="InParanoid" id="A0A194WY25"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="260" mass="27582" checksum="821BB8BCB94CB2A4" modified="2016-10-05" version="1">MYVYVPSKKLDPAPIIVAIHYCTGTAQKYFSGSNYASLADTHGFIVIYPNAPSSGGCWDVASTASLTHDKGGDSETIVNMVKYAVTNYGGDADKVYATGSSSGAMMTNVLAGAYPDVFKAGSVYSGVPDGCFYVAGATAGQATPGWSNSCANGQNIKTAQAWGDLVRSYYPGYNGTYPKMQIFHGTADNTLDYPNLAEQMKEWSNVFGISFVKNVTNSPQSGYTQMVYGDGTKLVGYSAQGVGHTVPIHESMDLSWFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYQ2</accession>
    <name>A0A194WYQ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_737982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067443.1">
        <property type="nucleotide sequence ID" value="XM_018220319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYQ2"/>
    <dbReference type="GeneID" id="28830045"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737982"/>
    <dbReference type="InParanoid" id="A0A194WYQ2"/>
    <dbReference type="OrthoDB" id="3553935at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267608" evidence="1">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="168" mass="18763" checksum="789A1977B6F2C05F" modified="2016-10-05" version="1">MFAFVTLLAAIFTSTVLAIPTQDQSAKTSPAISARDIIEYPIQATLCKNNPNDGNMCFISYVDNSIWVDPVLWVFDHNCVTIGYNGAVPRSEIEESYFGMSSELPDLVVIHAGLVFDDLNDIDFWYNNVHTYPTSDWGNIDAGWTENGVQAVDSSGTPWIWYRMAFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYT4</accession>
    <name>A0A194WYT4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067478.1">
        <property type="nucleotide sequence ID" value="XM_018213349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYT4"/>
    <dbReference type="GeneID" id="28823075"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673220"/>
    <dbReference type="InParanoid" id="A0A194WYT4"/>
    <dbReference type="OrthoDB" id="2819018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046580">
        <property type="entry name" value="DUF6640"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20345">
        <property type="entry name" value="DUF6640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="15398" checksum="D89036BA4432A344" modified="2016-10-05" version="1">MLGNILLSISALGQILGPFIADFNETHVMNPRWPPHARFHNGQTMSMGLALGLSSLYYAFRPTANVIVKQESIKTAAVFGTLYWVTGLSAILYPGSKGMDPEFGEGFPQFWMFSIFALCSLMGSYLETRQLKSQTPKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZL4</accession>
    <name>A0A194WZL4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_709200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067746.1">
        <property type="nucleotide sequence ID" value="XM_018217745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZL4"/>
    <dbReference type="GeneID" id="28827471"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709200"/>
    <dbReference type="InParanoid" id="A0A194WZL4"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="37884" checksum="2DAD19C7DF28935A" modified="2016-10-05" version="1">MKLPPSLFFLKPLHQGPDRHYRGVLYPVPGLSNYYSDFRGKAVPYPGNLTDPIMPTTNGTAAPDDQLYQNLLSAEWAIFSFYQQGVEMFNTTSFTSLGLPNTTYDRIQEIRDNEAGHLAIFQSQISSNSIKPGPCKYAFGVPSAEAFIVTLTLLEIASMAFLTGLVQQAQTDMTKGALTAIAETESRHNTWALMDIWDVDPFGGPADTSFPYANEILYSTNQFIIPGSCPAANPPYPYPSQDLPQFTYNPDTNSSLTSGTQIEYVFTTAPPAWNASQCYYAVFFHELLNISMPFDTTTNTTTIPEFDLDKGLIVGVIADTPGAPTLDTVVAGPVLLVEQPAGAIKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZV7</accession>
    <name>A0A194WZV7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_753795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067594.1">
        <property type="nucleotide sequence ID" value="XM_018221290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZV7"/>
    <dbReference type="STRING" id="149040.A0A194WZV7"/>
    <dbReference type="GeneID" id="28831016"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753795"/>
    <dbReference type="InParanoid" id="A0A194WZV7"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="96"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="261" mass="29445" checksum="259A0E2B02EBFD66" modified="2016-10-05" version="1">MRPARKYTTALYDLIYSLCFTALGSDAVVGTIQATTDCEATWQLVRTWLQTCEESHPTYAKRHIESILPTRLISVGTTNSELKIVPSQLLSSDIQYLTLSHCWGNKIFTTLRMENYSDFLTNIPEAGLSKTFRDAIYTTRELGFKYLWIDSLCIIQGDDTDWQTESALMGHVYSNSSLNLAAADAPDGDTSLFFDRDDTQSLAWRVSVPIVSGSHETRVWDCELASLAEDTISHCVLGTRAWTFQERFLSSRSLYFGRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1C4</accession>
    <name>A0A194X1C4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_720993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068129.1">
        <property type="nucleotide sequence ID" value="XM_018218607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1C4"/>
    <dbReference type="GeneID" id="28828333"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720993"/>
    <dbReference type="InParanoid" id="A0A194X1C4"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF101">
        <property type="entry name" value="HYPOTHETICAL ASPARTYL PROTEASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="634" mass="68209" checksum="A48D17446E19E722" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2A4</accession>
    <name>A0A194X2A4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">LY89DRAFT_784300</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32 33">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068695.1">
        <property type="nucleotide sequence ID" value="XM_018222773.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X2A4">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2A4"/>
    <dbReference type="GeneID" id="28832499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784300"/>
    <dbReference type="InParanoid" id="A0A194X2A4"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1693"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KUJ14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2094" mass="232499" checksum="0A3F24A2D3A474CD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2A7</accession>
    <name>A0A194X2A7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_751839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221237.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28830963"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="52951" checksum="A1201802A3E7E3ED" modified="2016-10-05" version="1" fragment="single">DRRFVYVQGDPIPTLSPLHIKISSYVFCFPEQVLEWILMEKIDGHTLDSVIEAGLSMGQKQRVYRNVARWVHQLSTLRFDKIGSLYCRWNPLRNPILSDFYLGPSSDFQFAYDYRQEYNIPRGPYDSVRDYLRGFVEIYQAETLDPRQHKRSQFWDLFNDFESQGTMHSKRQDLQLWPSLYSKSDLERIPQYCQSLRYVIPLIVKETTLPPRSTFLHHFDMSYKNIIVDREGVPIALLDWEQITTRPFSFGFPLPRFFIDQDYITTTRSLETSTTIENLRLKQDYLEYLQEFLSPNIHFVDKSNILDEEFEKLCEITYTIPESVQAEGYQFVSDVIAKRGMAWLDAPGLEDWKKQSSVDTNSPEFKQLPLDQQDMRTSRVTIVQIFWAWLCVLRAQKRFRAIRLQRLVQSERDSDQAQNSISRSSSLESLATSLITLDSRDSVLSKSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2G9</accession>
    <name>A0A194X2G9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_132035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068559.1">
        <property type="nucleotide sequence ID" value="XM_018205247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2G9"/>
    <dbReference type="GeneID" id="28814973"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_132035"/>
    <dbReference type="InParanoid" id="A0A194X2G9"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="34460" checksum="13489E0D26CD99FD" modified="2016-10-05" version="1">MNQHQADSEGEVRKFTCFPRFPEEIKRMIWKWSLAPRVVEVKFDCGGPPWRPYSESIVLYNSCETNPTHSGAPELKKEKCFYTITRTPVALEVCQDSRNAVLLFYPLSFGSVWYHPRIRFNFSLDTLYLDEDFYKVSPLFFSILNNEETTKLRYLALDYDSDGVRPGCGSYLKDKNFSKLIQRSVEGLKALRELIMVQQVQYWVAEAEFDVPGGHFDNRRDLEFDRTYLHETMLPFLKGRFPELRPWTEDWNVCKQTVLLGWRDSMIWYWKNDEGTEGGKCEKASDYQVPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2N7</accession>
    <name>A0A194X2N7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_736482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068803.1">
        <property type="nucleotide sequence ID" value="XM_018220124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2N7"/>
    <dbReference type="STRING" id="149040.A0A194X2N7"/>
    <dbReference type="GeneID" id="28829850"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736482"/>
    <dbReference type="InParanoid" id="A0A194X2N7"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="170" mass="18985" checksum="CBF00A88B0D1A04F" modified="2016-10-05" version="1">MATSAKAEAWEGESLAPELLLVITTKLPDLGALDSLLRASPNTFRLFNTENVVKITESILSSGSIHQHVRVIIYVIALIRSSALPISNLDDFTEQVMLEAMKTWPPALGSGFNPIRRSPTTSAVLRSILSTYRRITILTQGCLEFYLDRYRSLRPQHLADKTFRLHGVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5C1</accession>
    <name>A0A194X5C1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MNN4-regulates the mannosylphosphorylation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_698120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069624.1">
        <property type="nucleotide sequence ID" value="XM_018216959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5C1"/>
    <dbReference type="STRING" id="149040.A0A194X5C1"/>
    <dbReference type="GeneID" id="28826685"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698120"/>
    <dbReference type="InParanoid" id="A0A194X5C1"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43332" checksum="20AABACC3C33FE91" modified="2016-10-05" version="1">MLRTPAATRSVLKSFGKASIARSSYIAASAKFRNAPTASQLSNRRPKALVLPRDRPTTLSLLYATKSGPPYDHIDEKSEEKHSKEKIEPHPEDVSLGSSTRHVFEESQGKGATGNEVSGGMKHDLETIKETFSLAEVPRDALYIGAAGVLPYAATSLSTVYLAYDINHAHAHGTGYLFSPETAHQLLGLVTPIQIGYGAVIISFLGAIHWGMEFAGYGGHHGYRRYMYGVISTAVAWPTIFMPVEYALITQFLAFNFLYFADARASVRGWFPAWYSIYRFVLTFIVGASIVISLVGRGRIVKHDAAMRSPSDYIKVDRDAQWEALEREDKERRQALADTDEDGDEEESDDSEEGKDEDSDSEDSGDDKKSGDRKDAKSDSKESKGDDKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5J3</accession>
    <name>A0A194X5J3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_750779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069790.1">
        <property type="nucleotide sequence ID" value="XM_018221213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5J3"/>
    <dbReference type="GeneID" id="28830939"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_750779"/>
    <dbReference type="InParanoid" id="A0A194X5J3"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="287" mass="32875" checksum="14B8AB4B74CF104F" modified="2016-10-05" version="1">MTQSFLEDMYINFLMRQKIMKYVEDLHATLPINTDDFDMGKLELGSFSMDHISKAIIAYVKHGHSSRQEEAKDTFEFGGIFNIGKPENLPDLKRLFQLYNSAYFNGLLTDYCRIETVEACRISKRTGKKACLSGTCEIFRPGEERNPRYRIKDPYVKITIVQDKTRKCLRTSPEISKRTVKQHTGEGGHHLAWQATAQAIEEADEAGSAMFGFGTDLSRNELMARDMQLGYNHPDDAALRSVGLDIVEILKYRDAYRQEDAERDRLKDKIIFLRGSSCLRAHWAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5U9</accession>
    <name>A0A194X5U9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_588057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069527.1">
        <property type="nucleotide sequence ID" value="XM_018209461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5U9"/>
    <dbReference type="STRING" id="149040.A0A194X5U9"/>
    <dbReference type="GeneID" id="28819187"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588057"/>
    <dbReference type="InParanoid" id="A0A194X5U9"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047400">
        <property type="term" value="F:phosphonoacetate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.110">
        <property type="entry name" value="Domain 2, Phosphonoacetate Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012710">
        <property type="entry name" value="Phosphonoacetate_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023116">
        <property type="entry name" value="Phosphonoacetate_hydro_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02335">
        <property type="entry name" value="hydr_PhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="421" mass="46359" checksum="D378A15932AD5EC7" modified="2016-10-05" version="1">MSNTNGVPRSIEFYGRSYRLPRQPTVIVCVDGFDPEYLERGCADGILPNFSRFLESGFHVTAKCAMPSLTNPNNVSIITGVPTSVHDISGNFYLDKVTGEEHMVLDDSLLRGSTILEQMANNGVRVAAITAKDKLRKILNHGLSPSKGAICFSAQAAKSCTDAEHGISNVEKWLGRPAPEQYSGDLSIYVLDAGLKLLQENRADLFYLTLSDFIQHKYAPGSPESDDFLQLLDHRLGKFDELGAIVAITGDHGMSDKSNEDGSPNILFLETELMAKWPKCSARVICPIADPFVKHHGALGSFVRVHLLGELGTNDIEDMVQYCHSLSQVKAAYTGAEAATVFEMPPDREGDLVVVSEKNAVIGSREDEHDLSQLQGFRLRSHGGVSEERIPLIRSTPLCGRERVEPHVWRNFDVFDVALNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6M0</accession>
    <name>A0A194X6M0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_96874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070168.1">
        <property type="nucleotide sequence ID" value="XM_018223536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6M0"/>
    <dbReference type="GeneID" id="28833262"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_96874"/>
    <dbReference type="InParanoid" id="A0A194X6M0"/>
    <dbReference type="OrthoDB" id="5326346at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="86"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="45932" checksum="5725B0E9576EAA54" modified="2016-10-05" version="1">MSMTTSRLTFDPDGDLLLRLTYTVAKEKEREDNATGDSPVPSNISSPLGLFTNLKLAPIRDGHSMDEDEEEEVTWEVEMLVSAKHLMLASPVFRAMFKHSFLEGETLRSTGKVEVSLPDDDTTAMEIVLNIIHGRVRQVPKEVTMDVMTALSILVDKYQMHEVVELYVEIWMVRLKASVPKFFSPELYKWLSVAWVFKLPQEFKHLTWIAVRESCGSNSIMQLPPDPSLPIPEVVLGEIEEQRRKSISDTLSIITILKDKLTAPSPGTIWARPEAARVCTSTFGSIDIDNKRYSCEGMILGTLLKGLSDQRLWPPPSNPYRAFSFKSIALAVRSLKITSLCDTIQNAPAFKTPAGFTFGSSVSSMQHQAHGQLKWVHDQVDQIESRIMGLDLEIFTGKGQSALAQSTEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6V9</accession>
    <name>A0A194X6V9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_647957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070266.1">
        <property type="nucleotide sequence ID" value="XM_018211979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6V9"/>
    <dbReference type="STRING" id="149040.A0A194X6V9"/>
    <dbReference type="GeneID" id="28821705"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647957"/>
    <dbReference type="InParanoid" id="A0A194X6V9"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="77" mass="9022" checksum="20249395585CFBB9" modified="2016-10-05" version="1">MLIARRFSVTNFVIASSALAFQVFVLYPWHQRLDEDLESLKKEHVRVLQELRNEVKVGRETTLGEIRELIKGRALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7D8</accession>
    <name>A0A194X7D8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">LY89DRAFT_103253</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070450.1">
        <property type="nucleotide sequence ID" value="XM_018205024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7D8"/>
    <dbReference type="STRING" id="149040.A0A194X7D8"/>
    <dbReference type="GeneID" id="28814750"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_103253"/>
    <dbReference type="InParanoid" id="A0A194X7D8"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000233">
        <property type="entry name" value="Probable glucan endo-1,3-beta-glucosidase eglC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267937" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KUJ16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="37955" checksum="E526E7C66943FD33" modified="2016-10-05" version="1">MRSSGLLAFAASLATSSAVYQGFNYGATKSDGYTVRAQADFESLFSTAKSLVGASGFTSARLYTMIQGGTTNTPTSAIPAAIAQDTSLLLTLWASGTTFTDELAALKSAISTYGSQLSGKVAGISVGSEDLYRNSPTGIAAGSTIGADPATIVDYISQVRTAIAGTALSSVGVGHVDTWTAWVNGSNDAVISACDWVGVDAYPYFQNTETNGIDQGASLFNEAFDNTKGAVGSKPVWITETGWPVTGKTENLAIPSADNAKTYWDQVGCPNFGVVNTWWYTLEDTDDSATPNPSFGIASAPVQVFHQAAWEDQERTLPRPEVAQAQLPLDLLDQPPPLAQPPSRPMLPTSCLARSLVLWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7I3</accession>
    <name>A0A194X7I3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">LY89DRAFT_669667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070476.1">
        <property type="nucleotide sequence ID" value="XM_018213117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7I3"/>
    <dbReference type="FunCoup" id="A0A194X7I3">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7I3"/>
    <dbReference type="GeneID" id="28822843"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669667"/>
    <dbReference type="InParanoid" id="A0A194X7I3"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="342" mass="36418" checksum="407CA7653AAECAC6" modified="2016-10-05" version="1">MAPSLEAPESVQDVLSNPLKSAPKLVAPEPEHCPGPESETAGKADSCAGCPNQAICASAPKGPDPDIPAITARLSGVKHKVLILSGKGGVGKSTFTTLLAHAFATNPENTVGIMDTDICGPSIPKMMGVEEETIHVSGAGWSPVWVMENLGVMSVQFMLPNRNDAVIWRGPKKNGLIKQFLKDVEWGEMDFLLVDTPPGTSDEHLSVNSFLKESGVDGAVVVTTPQEVALLDVRKEIDFCRKAGIKVLGIVENMSGFVCPKCTHQSQIFQATTGGGRALAKEMKIPFLGAVPLDPRIGMACDYGESFFDAWPDSPACTALREVVKRVGEEMGLKPETLLPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7V2</accession>
    <name>A0A194X7V2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_734355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070600.1">
        <property type="nucleotide sequence ID" value="XM_018219902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7V2"/>
    <dbReference type="FunCoup" id="A0A194X7V2">
        <property type="interactions" value="1380"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7V2"/>
    <dbReference type="GeneID" id="28829628"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734355"/>
    <dbReference type="InParanoid" id="A0A194X7V2"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="324"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="519" mass="58896" checksum="102148BC82F263E1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8D1</accession>
    <name>A0A194X8D1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_585928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070788.1">
        <property type="nucleotide sequence ID" value="XM_018209348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8D1"/>
    <dbReference type="GeneID" id="28819074"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585928"/>
    <dbReference type="InParanoid" id="A0A194X8D1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="55803" checksum="8C60C782BBDD192B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8Y1</accession>
    <name>A0A194X8Y1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">acylphosphatase</fullName>
            <ecNumber evidence="2 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_586392</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070981.1">
        <property type="nucleotide sequence ID" value="XM_018209364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8Y1"/>
    <dbReference type="STRING" id="149040.A0A194X8Y1"/>
    <dbReference type="GeneID" id="28819090"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586392"/>
    <dbReference type="InParanoid" id="A0A194X8Y1"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11437" checksum="E9ED3D33D9BB86BE" modified="2016-10-05" version="1">MRCTLGVGFRYGNSCRLLQSKISPDQNSRYYTRKKAASYGITGWVRNTANSKVEGEAQGEDDVLSKFMKDIDKGPTHSHVVKLEKKEIELIDGEADFEVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X958</accession>
    <name>A0A194X958_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_684790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071055.1">
        <property type="nucleotide sequence ID" value="XM_018214954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X958"/>
    <dbReference type="GeneID" id="28824680"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684790"/>
    <dbReference type="InParanoid" id="A0A194X958"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="76" mass="8215" checksum="D1FFE5D48DEEBBF3" modified="2016-10-05" version="1">MHPLIEVGLAYVVFGTCVVLLSPFLLLLRIGKKHQSSRPATAPRSATAQTPSTSKSTHFTKWQYTKAVSTSSQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9H4</accession>
    <name>A0A194X9H4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_707282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071171.1">
        <property type="nucleotide sequence ID" value="XM_018217590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9H4"/>
    <dbReference type="FunCoup" id="A0A194X9H4">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9H4"/>
    <dbReference type="GeneID" id="28827316"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707282"/>
    <dbReference type="InParanoid" id="A0A194X9H4"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ16816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="156" mass="17351" checksum="381FD600EC5CBE79" modified="2016-10-05" version="1">MLTRRVLLDAADAESPLKPAELQVLRSQYEKEGEHVGVQTKFNFAWGLIKSNTRPDQQEGVRLLSDIFRTSPERRRECLYYLALGNYKLGNYAEARRYNDLLLDKEPANLQASSLRGLIDDKVAREGLMGVAILSGVAIAAGVVGGMIFKGVGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAM2</accession>
    <name>A0A194XAM2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_748545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071575.1">
        <property type="nucleotide sequence ID" value="XM_018221153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAM2"/>
    <dbReference type="GeneID" id="28830879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_748545"/>
    <dbReference type="InParanoid" id="A0A194XAM2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="275" mass="32978" checksum="D940D4D915C80416" modified="2016-10-05" version="1">MEFTPEYQSGFIAAFLASQPAPPANDHETPEQARTRIHDLFEDIRSRYLDSIYDRFYSKQTDPADRNLEVLGNARARFEEEIETTRFRYQTEAVNQTNNTQRQELEPEIHSLEIQATNPKNESGDDLAQQIRQAEILQSRKEALDREQVEMEAGFGIRKDEKSARECDERIRSLVRKEREKRQREQERLRRNRVELEKKRIDRLIMERERALEREKRLQKTMKDLERREKKIAGSIALAKLEAKRKKAILDKETKRVREERRRLPTGRQPRKYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAQ7</accession>
    <name>A0A194XAQ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_669630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071579.1">
        <property type="nucleotide sequence ID" value="XM_018213112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAQ7"/>
    <dbReference type="STRING" id="149040.A0A194XAQ7"/>
    <dbReference type="GeneID" id="28822838"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669630"/>
    <dbReference type="InParanoid" id="A0A194XAQ7"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="350"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1262" mass="140629" checksum="29D9807129FC052D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAV3</accession>
    <name>A0A194XAV3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_696787</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071655.1">
        <property type="nucleotide sequence ID" value="XM_018216857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAV3"/>
    <dbReference type="STRING" id="149040.A0A194XAV3"/>
    <dbReference type="GeneID" id="28826583"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696787"/>
    <dbReference type="InParanoid" id="A0A194XAV3"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268078" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="174"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="735" mass="80413" checksum="6D11F305C399C7E2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBR9</accession>
    <name>A0A194XBR9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_734183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071557.1">
        <property type="nucleotide sequence ID" value="XM_018219886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBR9"/>
    <dbReference type="GeneID" id="28829612"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734183"/>
    <dbReference type="InParanoid" id="A0A194XBR9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="325" mass="37483" checksum="F5F2B5155131B19D" modified="2016-10-05" version="1">MHRKKCQILKGKHLAKEHFEWCWLQHVQASKRDADELQLILANNERARFIRPPELVDPDERILDYFGRHFAYNRTAIRDNAWEAIVKIAPERTLLMLVLTELFSAYIRCEYREKELMRVNYQSRASVLTTLHQWQSKVDLTGIDAESLGIVLLGGMMVVLQQMIGPDDDQQAWAHEILWIPFLIQKTLHAVTSVPKILPLTFELRAKLNPHITMANMLAPLHAQLPDSGYLAEAEWQNSQLMCTIDPLVGASHAIMWAIRETNLICKGSSQISPEKLLLYIKSIEQRYPEGGEPRDNDHIIYKQILFDGERGYQILAKSSCVVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBW0</accession>
    <name>A0A194XBW0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quino protein alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_684632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyrroloquinoline quinone</name>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial PQQ dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072001.1">
        <property type="nucleotide sequence ID" value="XM_018214921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBW0"/>
    <dbReference type="STRING" id="149040.A0A194XBW0"/>
    <dbReference type="GeneID" id="28824647"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684632"/>
    <dbReference type="InParanoid" id="A0A194XBW0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303:SF10">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303">
        <property type="entry name" value="QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="4">
        <location>
            <begin position="71"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="34636" checksum="AF50B511EA7FA4EF" modified="2016-10-05" version="1" fragment="single">MMPAHANFSGASIWGSQPAIDPIRRQVFLATGNTYSLPEEFQACQNQTANITVIKEGLAPEPCLPRDVLQESILALDLDTGRVNWQRQLGPLDAWNAACTVGLLGPGLPGEQASCPSTPGIDADFGMAPTFVLGSEHTPSELDIIVIGQKNGNLYALNAATGHILWLTSTGPDGLEGGLNWGIAADDTSVYYTAININRVNYTLPAGDGKTVISNSAFGAASLKDGKILWQTASPRNTTSIIVPSVVNDLVLTGITGNWSATSIFPAGPGSLLSLDKKTGRIVKEVHLDAYFHGGMAIVHDYVMFGSGYGGLEPPNPGSFQTWKLTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC79</accession>
    <name>A0A194XC79_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_733600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072133.1">
        <property type="nucleotide sequence ID" value="XM_018219821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC79"/>
    <dbReference type="GeneID" id="28829547"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733600"/>
    <dbReference type="InParanoid" id="A0A194XC79"/>
    <dbReference type="OrthoDB" id="3832365at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="15719" checksum="9E801955327BA0FF" modified="2016-10-05" version="1">MSEETREGKKSEEELVSGAMIRKRKGEEEDKEYDYCVTQVPLRLASINDDLFRNDTHFSYSEKGPLAFMGNYRPKTDAMKVDAMQVNITLLGLYLGQFQGSLEKGMSIKVDLFSIKGDISFRLGLYNSKKRSGQSGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCL0</accession>
    <name>A0A194XCL0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_732622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072268.1">
        <property type="nucleotide sequence ID" value="XM_018219705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCL0"/>
    <dbReference type="STRING" id="149040.A0A194XCL0"/>
    <dbReference type="GeneID" id="28829431"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732622"/>
    <dbReference type="InParanoid" id="A0A194XCL0"/>
    <dbReference type="OrthoDB" id="5426294at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268072" evidence="3">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="26755" checksum="78B95BF3D1F7A9E9" modified="2016-10-05" version="1">MKYTATLIALSAAFASAQFTINSTTDEITCYGNPNGAYCASSSLSSNIIIRCVNGTGQAGNCNDNLSGYFPYGLEGAECWETSTTSGDAACAKNCIVECGSGNCGESFTLPNCTPSATQSASSTLSTVVSSSTSSPVSLSSSSITSSPSASTTPSTSVTITSTGTSICTTGGTTETITFTTTYCPESTASASSSVVLTTTPISATTYPLSTGTGSPSSSTAASNGTATKSGSATPVGPSGTTTASPSTYTGAAMANSAGAGLAAIGLFIAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCZ1</accession>
    <name>A0A194XCZ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_733460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071977.1">
        <property type="nucleotide sequence ID" value="XM_018219801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCZ1"/>
    <dbReference type="GeneID" id="28829527"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733460"/>
    <dbReference type="InParanoid" id="A0A194XCZ1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30130" checksum="89234BCBE7560AEF" modified="2016-10-05" version="1">MSVEDVDTSSRPLVETTLRLVGVGSSDEGIEKLLLVLKSDTLVGTALTTIKVEDVDAEVMLPAVVDSTSRIVDVSDERLGKVLLGLMSTTLADPRLASEFVEDVATSKLLVGSAFVDIESNGRVGELLAVLTSTTLIGVALKTWDIEDVVTGNRQLVDATLKFVDVETDERFDKVLLVLPGTKIESDEVVDLDRVCKELLVLMTPITLRVVVLNGLGEVNEEPLAGFELPCVEERDLELDVKDTLEDLEEGVPGIFEEEIDESVEERVCDAFLEETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD72</accession>
    <name>A0A194XD72_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">LY89DRAFT_644040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072480.1">
        <property type="nucleotide sequence ID" value="XM_018211819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD72"/>
    <dbReference type="FunCoup" id="A0A194XD72">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD72"/>
    <dbReference type="GeneID" id="28821545"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644040"/>
    <dbReference type="InParanoid" id="A0A194XD72"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ18125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="18822" checksum="2A3010AC4507A9FA" modified="2016-10-05" version="1">MEALNLDDAPPPQVLGQPPQQNQQLPPQMFTTAAQLLDLTDKKLMVSLRDGRKLIGVLRSWDQFANLVLQQTIERIFVPSLSPSEPGLFADVPRGIFLVRGENVTLLGEIDLDKDDDTPTGYERADVEVVHRLWRERKGREAKRERGRRARLLREVGFEGEVLGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDC6</accession>
    <name>A0A194XDC6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_60739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDC6"/>
    <dbReference type="GeneID" id="28820183"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_60739"/>
    <dbReference type="InParanoid" id="A0A194XDC6"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="429"/>
        </location>
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        <location>
            <begin position="447"/>
            <end position="495"/>
        </location>
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            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
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            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="495" mass="56496" checksum="6B2B2DAF5BBE5761" modified="2016-10-05" version="1">MDPSSGRDSNSNSNSSSNSPSTPENPFIRFKNFADTQISTLLQGVIGLPSAFSKRSSEDGRWADIDEDLRRRDRLQARDRMLKAQLDMKSASGEEIPVQKLAKQQVPQTSDQVPSSGEFWKDTKSYAGLERREGSNVEMDLPLYSPVTRELFDNVRRPEYQSDLDRSRLSPGENSFKDFQFALMNDLLDRREPLRATRLLAFEHVKDNPSLRSDYSLLPYLLFSPYSPLKLDADIHGWGALPDSYPVGRPLYCAAFDDLIRTTQGLKEPPTPIYQMSLPWSTTGLSDFDNWRWIKDLYRRGMLQQKGSVWAPMPASQIWKDLAVQEDSGTELDAFEQLHKLMGNGATLLATVQSMFDALNPEEQRQSGSTNLHDMIAQARERAIIEDRQSQSTIPPKQEKDKKQVTNDVRPDRIVSTSTTTERTTHEDGTVETCVTIWKRYDDGRETTTTTTHTEDPGWDDKEQPDWPDEAASRQVGEKNLEDDKKDQKKGWFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDG3</accession>
    <name>A0A194XDG3_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">DUF1741-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_41393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDG3"/>
    <dbReference type="STRING" id="149040.A0A194XDG3"/>
    <dbReference type="GeneID" id="28817078"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_41393"/>
    <dbReference type="InParanoid" id="A0A194XDG3"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="627" mass="70344" checksum="4B9EF0A9F37064DE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDT6</accession>
    <name>A0A194XDT6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_717889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072669.1">
        <property type="nucleotide sequence ID" value="XM_018218378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDT6"/>
    <dbReference type="GeneID" id="28828104"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717889"/>
    <dbReference type="InParanoid" id="A0A194XDT6"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268176" description="FAD-binding FR-type domain-containing protein" evidence="12">
        <location>
            <begin position="19"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="436"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ18314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="766" mass="85347" checksum="D043491F5EAF8A04" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XES4</accession>
    <name>A0A194XES4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_684183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072612.1">
        <property type="nucleotide sequence ID" value="XM_018214829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XES4"/>
    <dbReference type="FunCoup" id="A0A194XES4">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XES4"/>
    <dbReference type="GeneID" id="28824555"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684183"/>
    <dbReference type="InParanoid" id="A0A194XES4"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ18257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="17921" checksum="1345E725154C8C49" modified="2016-10-05" version="1" fragment="single">RLIPKADRKKIHEYLFREGVLVAKKDYNLPKHNDIDTKNLYVVKACQSLTSRGYVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEIVPATHIKQQRSHAPPRGMMGGEGERERKPFGGRGGRGGDRDRGDREGGYRRRDAGGEGKEGAPSGEFAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEU1</accession>
    <name>A0A194XEU1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_643071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073021.1">
        <property type="nucleotide sequence ID" value="XM_018211784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEU1"/>
    <dbReference type="GeneID" id="28821510"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643071"/>
    <dbReference type="InParanoid" id="A0A194XEU1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32864" checksum="3672F49A56E5FADD" modified="2016-10-05" version="1">MLEGFVSFTYTIDPGVAIHGVRGGAGPPLLLLHGFPQTHRIWDRVAAQLKNDFAIIAIDLRGYGASSKPSGVEHYAKSAMARDAARIMAMFGHLSYFVCAHDRGARVAHKLCVNYPERVRKAIFLDICPTLAMYTKTDFDFAKSYFHWFFLIQKSPLPETLISGNPRKFLEMFTGPRTDRSTFLDEAWEEYVKALEDPAAVHSMCEDYRASASVDLDEARKDIEDGRKIQCHLRVLWGKKGVIEKCFDALAEWRSVCEGEVSGHVVDSGHYIPEEKPDVVIENIREFFLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFI5</accession>
    <name>A0A194XFI5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_498740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072887.1">
        <property type="nucleotide sequence ID" value="XM_018207943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFI5"/>
    <dbReference type="STRING" id="149040.A0A194XFI5"/>
    <dbReference type="GeneID" id="28817669"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_498740"/>
    <dbReference type="InParanoid" id="A0A194XFI5"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24120">
        <property type="entry name" value="GH07239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24120:SF4">
        <property type="entry name" value="GH07239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="222" mass="24758" checksum="E0FD6B69844A0B6C" modified="2016-10-05" version="1">MLKHIEDTQVLLEIVVIGGQVDHGRENEEGDMLLSKAAAGGHRRAVRALLYGSHDDINTRDKMGRTPLFWAAEGGHLDVVRELVKEGAEVSFEDQDNFTAKDLAYRRGHSEIVSLLEPLMQRDDEKGKKLSVFAMSITPSSWKSDAAYHSASCTSPPTTPLYPKRRQTGSNILKECHKDGGRRRLKSFQTSCWRIRVGRVSGIVLAASVVTWLMKGEEIMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFY6</accession>
    <name>A0A194XFY6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_695772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073465.1">
        <property type="nucleotide sequence ID" value="XM_018216785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFY6"/>
    <dbReference type="STRING" id="149040.A0A194XFY6"/>
    <dbReference type="GeneID" id="28826511"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695772"/>
    <dbReference type="InParanoid" id="A0A194XFY6"/>
    <dbReference type="OrthoDB" id="5304883at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="35470" checksum="1C44D3ACF60A09DB" modified="2016-10-05" version="1">MSPTRSANSSDSFYILPPRPNPSADAGLSIKADSDGSNTPPSPSSMDVFKISPVTALKLLCAGIEALVKVTGDIPPTPPPTFTTPPNMRGMQAEKENIIRSNSYKNFAELHKRPRTPSSSSGGSEDIDGVNFRKTPLSSPEIAPTEPYIIIGDNAEPLNVQHSVITRKFYSKHPPPISLEDYLMRIHKFCPMSTAVYLATSYYIHKLAVDERAIPVTRRNCHRLLLAGLRVAMKALEDLSYPHSRFAKVGGVSENELARLEISFCFLTNFEFKTSKETLLEHAISLKELSAMQGAVGFVPRMPLKSKRRVGAQETVQEVTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG45</accession>
    <name>A0A194XG45_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073454.1">
        <property type="nucleotide sequence ID" value="XM_018214622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG45"/>
    <dbReference type="GeneID" id="28824348"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683041"/>
    <dbReference type="InParanoid" id="A0A194XG45"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="97" mass="10620" checksum="218000CFB2D98211" modified="2016-10-05" version="1">MSSILSFGSGTWDCCNCSCSCCDGDNGSIATGGGGNSGADVGWIDLGGDSGDGSRNEERERRRREEQQRKQNQQQPQQEQMSYVASNDHRDDLKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGB4</accession>
    <name>A0A194XGB4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron transport multicopper oxidase fet3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_612778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073563.1">
        <property type="nucleotide sequence ID" value="XM_018210637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGB4"/>
    <dbReference type="GeneID" id="28820363"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612778"/>
    <dbReference type="InParanoid" id="A0A194XGB4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268272" evidence="6">
        <location>
            <begin position="20"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="152"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="366"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="570" mass="62305" checksum="A3FEF5EFEF69DE3E" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHD6</accession>
    <name>A0A194XHD6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_613243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073894.1">
        <property type="nucleotide sequence ID" value="XM_018210656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHD6"/>
    <dbReference type="STRING" id="149040.A0A194XHD6"/>
    <dbReference type="GeneID" id="28820382"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613243"/>
    <dbReference type="InParanoid" id="A0A194XHD6"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268250" evidence="5">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="44430" checksum="39591253CAFC54D5" modified="2016-10-05" version="1">MRLETLSLLVLCGVIGVVVGHEHHGHDHDHAEKEIPLHEQEYIQDNTEELERKWGFEWGYNGVNSFAHLEHVKCLTKPDTLFDIGILGVPFDTAVSYRPGARFGPRAIRAASSRQTSFRGFNPRAGINPYMSWAKILDCGDVPVTPFDNAVALTQMTSAYLELGHRSSLSSVIPKPKIITLGGDHALALAALRGLNKVYGQSIAVLHFDAHLDTWHPAKYPSPWPSKQAEFNHGSMFWIASNEGLILNGSSVHAGLRTRLSGDDWADFEDDTNQGFLRISADDIDDLGPKGVVDTIMARIGTETPVYVSVDIDVLDPGLAPGTGTPEAGGWTSRELIRILRGIEGLNIVGGDIVEVAPAYDGAGEQTALAGAQVVYEILTSMVKRGLVDMGKTAEVPGRDARGRVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHX3</accession>
    <name>A0A194XHX3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_580200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074175.1">
        <property type="nucleotide sequence ID" value="XM_018209045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHX3"/>
    <dbReference type="GeneID" id="28818771"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_580200"/>
    <dbReference type="InParanoid" id="A0A194XHX3"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="188" mass="20424" checksum="A18D335C3D53C76B" modified="2016-10-05" version="1">MEFINSILECLGASSHEATLRVTSNAHTRLEQPPYKNDPAEEELAARILNTLFTSEKSGDALAFQLQSHFSTSSWTESLARRILDGIVAALASGQVLVGAMQETYDKVQVVAEDFVKEHPILTEVILTVIAIGILALLVPWAVEALGFGELGPSADSFAAWWQSTFPDAEAGSLFSYLQRLGMKRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI44</accession>
    <name>A0A194XI44_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_682731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074250.1">
        <property type="nucleotide sequence ID" value="XM_018214558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI44"/>
    <dbReference type="GeneID" id="28824284"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682731"/>
    <dbReference type="InParanoid" id="A0A194XI44"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268275" evidence="1">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="362" mass="37648" checksum="EED6A0CBC0C95045" modified="2016-10-05" version="1">MKTSAVLSLALLGLATASPVALPQDIDFDSYDSIPVAVDKSAPVNPVVAPAAVSYDPSAAITSAVSAATAAVDADLNKREIHLVEKRGSCNASPAGNAPAVSPDTDIAFLTNPDFATAANGATPPPGYFLAVGYQNLAASASSPSYLTYISDPLTSYDPAQCATACNAMTGCVSFNIFFERDPSIYVDSVNCPTASSVTRIKCSFFGAPITVADATNAGQYTGNFHVVIAGSNTYTTAPQPLPGFTGPVSVNNASIISPTAANTYMGVQSFVMTQPFDPSVCAAACTEKSAYNTRHAVAGVAPRLCMFFDAYILYKNGANGVFTCTYYTQAYDKSYATNFGQYNSAGDHFTIGHSYLYSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIF4</accession>
    <name>A0A194XIF4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_465594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074266.1">
        <property type="nucleotide sequence ID" value="XM_018207714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIF4"/>
    <dbReference type="GeneID" id="28817440"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_465594"/>
    <dbReference type="InParanoid" id="A0A194XIF4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="229" mass="25759" checksum="459B5BC3F0BCBDA8" modified="2016-10-05" version="1">MLDEQPLFIFLYIQDYWKEGRKERRMVFRKEGMDRSMNEYTPLYDLFISTQSLSLSSLPVSDMLTLPLPFLPVPLLHARHSPTPNPSTVYRSSHTDHMTADPPSTCKPTFPSRHKLPLLASWPSLFSSHSLNGTKLWLGLAGCVTADMPRFSSDTCSSSGNLILIRQLERCRAKSHASWCLVCGGNVGRLEELLGEGVVGALCNWEFCASWVFGVMGVDLWPRGFEVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIJ3</accession>
    <name>A0A194XIJ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_581626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073942.1">
        <property type="nucleotide sequence ID" value="XM_018209120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIJ3"/>
    <dbReference type="FunCoup" id="A0A194XIJ3">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIJ3"/>
    <dbReference type="GeneID" id="28818846"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581626"/>
    <dbReference type="InParanoid" id="A0A194XIJ3"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140787" checksum="11CD9FFD3E1A37D1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJI5</accession>
    <name>A0A194XJI5_MOLSC</name>
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        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_682069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214433.1"/>
    </dbReference>
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        <property type="interactions" value="875"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJI5"/>
    <dbReference type="GeneID" id="28824159"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682069"/>
    <dbReference type="InParanoid" id="A0A194XJI5"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="SNF2_N"/>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="375"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="473"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="775"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1316"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1519"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1061"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1334"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1363"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ20313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1542" mass="176669" checksum="6551322785C69C08" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK15</accession>
    <name>A0A194XK15_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_771352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK15"/>
    <dbReference type="GeneID" id="28831607"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_771352"/>
    <dbReference type="InParanoid" id="A0A194XK15"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268330" evidence="1">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="364" mass="41499" checksum="848FD6195B8C2728" modified="2016-10-05" version="1">MIFLAITFFLLFILCILLAIQPSLLQPLLSWHPLPHAKLTDSRRPSLGTTETKITQDIAPYQFPPLRPKSSSRMAMGLKRLDASNWLTLDSSYLPEHSLRLSLLESRHADVIQCLPGSQASCHEVLDLVTSFLASRFPQHYSLRTTASEPCIESHLTGEVYPIGEKCENPLEVAARLAMEDFNVLIKNQETREYHLMASATLFPAGWKLQERIGYSMARLHGPVPAWKEKLGGSVNRYFDHLSSKTAMERTNLFIQTTTELFQNAPEDPLARALTAKDLMVRRERQTFVRLEKTDAVLFTVRTYMQSMTGLGNEEIRALRSQILGWEEEVRLYKGFAIWGEVLMKWCEEMVGGVQREAEVKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKC4</accession>
    <name>A0A194XKC4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_682305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074946.1">
        <property type="nucleotide sequence ID" value="XM_018214479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKC4"/>
    <dbReference type="STRING" id="149040.A0A194XKC4"/>
    <dbReference type="GeneID" id="28824205"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682305"/>
    <dbReference type="InParanoid" id="A0A194XKC4"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="34482" checksum="5E45899361E526B3" modified="2016-10-05" version="1">MVNVLIIGATGYIGTAVCQSLIRSGDHRVFGLARSPEKARLLEKDEIIPILGSLTDTKSLIQSLATKYIDVVVDLSGDPKESESFLHVLKYIGAEKFKQAATAGVRVPKLGYIYCSGTWVHGSSQTAVNDLYPVGALNAPTPPVELTAWRAKLEQVVLASSDVLDVMVVRPALVYGRSSAIWSSLFEPLHISAQNGEKSVDVRVEADSRPALIHVDDVATGFHAAIDKLPLIAGTGVYPVFDLVTSQESMREILDAAARELGFNGKVNLVGAGEHLFAKAISASASLNAGRARTILGWLPKRSEYVVSMDIFAKAWLTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKQ0</accession>
    <name>A0A194XKQ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Npp1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_682412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075071.1">
        <property type="nucleotide sequence ID" value="XM_018214505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKQ0"/>
    <dbReference type="STRING" id="149040.A0A194XKQ0"/>
    <dbReference type="GeneID" id="28824231"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682412"/>
    <dbReference type="InParanoid" id="A0A194XKQ0"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268392" evidence="3">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="25243" checksum="05DC6EF32CBD3722" modified="2016-10-05" version="1">MAVLSRLLAGLLATVAVNATPFTLQNRGTIASDEIVGFAQTVPSGTVGDVYLAYQPYLYVVNGCVPFPAVDAEGDTNAGLATTGASNGDCSSSTGQIYVRGTTYDDYYALMYSWYMPKDEPSDGLGHRHDWEGVIIWLTSSTATTAANIVGVCPSAHGNWDCSTDGFTLSGTAALIDYESIWPLDHSCGLTTTVGGTQPLIAWESLPTVAQTALDDTDFGSAIVPFIDAHFTTNLAAATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL94</accession>
    <name>A0A194XL94_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_640184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074902.1">
        <property type="nucleotide sequence ID" value="XM_018211655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL94"/>
    <dbReference type="GeneID" id="28821381"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640184"/>
    <dbReference type="InParanoid" id="A0A194XL94"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF47">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="22280" checksum="C1ABABA87E9C80A1" modified="2016-10-05" version="1">MPYEIIQIPRDDESIRTWVEQCKAIRLYALKTAPEAFGSTYAREIAFTDEDWYNRLANPVATTCIAVQSNQIVCSLVGIGPLPCTPEESSPTKNPWELSKDPGATAQLHFRINGMFTLPEARGQGIAKALIERFFEHGKEEANKVGKNFVCSIVVDADNTPAKNLYEKCGFVSLIQETYPESSRVAILMKYPATSEKTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLI2</accession>
    <name>A0A194XLI2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_682340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074987.1">
        <property type="nucleotide sequence ID" value="XM_018214489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLI2"/>
    <dbReference type="FunCoup" id="A0A194XLI2">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLI2"/>
    <dbReference type="GeneID" id="28824215"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682340"/>
    <dbReference type="InParanoid" id="A0A194XLI2"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <begin position="48"/>
            <end position="65"/>
        </location>
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            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
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            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
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            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="446"/>
        </location>
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        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ20632.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="902" mass="96946" checksum="1929964F4272C942" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLK9</accession>
    <name>A0A194XLK9_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_716012</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_716012"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="548" mass="61045" checksum="C65EFB82CEBBD521" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN81</accession>
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        <recommendedName>
            <fullName evidence="4">Alanine racemase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">LY89DRAFT_546065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208242.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
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        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
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        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <position position="35"/>
        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27474" checksum="B75BF3185B8A34F2" modified="2016-10-05" version="1" fragment="single">DPSRASALSSALKSIQQRISTAAKGRSVRLVAVSKLKPASDILALYNEGQRHFGENYAQELLEKAAVLPRDIRWHFIGGLQSNKCKPLTSTLPNLFLVSSVDSPKKATQLDKGRSELSPSPDSPLNIHIQINTSNESSKSGVSPGFEATALAKHIIDTCPNLNLLGVMTIGAIARSQEGGENEDFATLLRERDRLEEELGEGWKGRLECSMGMSGDFEEAVRGGSGEVRVGSTIFGERPRREDFVVKGEVEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XND0</accession>
    <name>A0A194XND0_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">LY89DRAFT_576166</name>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076006.1">
        <property type="nucleotide sequence ID" value="XM_018208826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XND0"/>
    <dbReference type="STRING" id="149040.A0A194XND0"/>
    <dbReference type="GeneID" id="28818552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576166"/>
    <dbReference type="InParanoid" id="A0A194XND0"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="31639" checksum="03EE392A36F7399E" modified="2016-10-05" version="1">MAPPGPTFDLYKELELTAGATAADITASYRRLALLHHPDKNENSVEATAKFQRLNTAHEILKDTAQRGEYDRRSSGSNFGFSDAADFFNSEDGYDSADEFDPDLRDPFDIFWSHFDHRYGTPEPQESDTEEEKQKARDPARDQARDQAQEKAREAGGAREKQRQQDAEMATDKEKARRKENADKSKGWDEKKYKEPRQRQEQVWRLRGDTTPAAKQKSCPHIDFWPKEEGNKKGEKVKCGSCTKKRGTSFKCPLCDLVACQVCVSDFSKEREKAAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPR3</accession>
    <name>A0A194XPR3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_665309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076538.1">
        <property type="nucleotide sequence ID" value="XM_018212834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPR3"/>
    <dbReference type="GeneID" id="28822560"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665309"/>
    <dbReference type="InParanoid" id="A0A194XPR3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="522" mass="57099" checksum="585267E1DC271827" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR25</accession>
    <name>A0A194XR25_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_728758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076993.1">
        <property type="nucleotide sequence ID" value="XM_018219301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR25"/>
    <dbReference type="STRING" id="149040.A0A194XR25"/>
    <dbReference type="GeneID" id="28829027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728758"/>
    <dbReference type="InParanoid" id="A0A194XR25"/>
    <dbReference type="OrthoDB" id="3510203at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="1">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="473" mass="53138" checksum="811BCDC2D196E131" modified="2016-10-05" version="1">MWGCFLAQEASTPMTEDKLRNIFEALDLDEPSFEQPPSEGVKATKPTTSTTWTLKKDEAEDEEKLLAIYCLYEDLNLLRQDIGMLWTDYRAGRSDLVSVSVATNAALEFGIYVEAEFLETYPDLTTGYKIMIALLSIFRSPGWSSTFLAVETEQIDKGCYVVVKQVLGYWLSMDALTAWTTVTSIDQMVLSAVCASNSQVYQQDVQKDIESKAADAYELRILRYKSDLFSIASEAAVHEVLHHELPVVDLVTQTLRDSIANRAGGKSLSAVFSSQAFLDIKEIMGESVSDGFNELRRFRDYLDVQRDLSSLVSSAKGSLDKMKRLIDEDICQQWKNEARSQMFHANGSRLAADSVPAPAFKLLKEHPLLCGLLLFYCQMNLQRVGMHSADSRISILACSHLYNAVQKAQLLSRQWDDLEHIFSNHSDKDFFLGSRPETLTTILRQWALVNGISTTFFSNHASKCEICTGSSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRF4</accession>
    <name>A0A194XRF4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_575509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077128.1">
        <property type="nucleotide sequence ID" value="XM_018208792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRF4"/>
    <dbReference type="FunCoup" id="A0A194XRF4">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRF4"/>
    <dbReference type="GeneID" id="28818518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575509"/>
    <dbReference type="InParanoid" id="A0A194XRF4"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000053">
        <property type="entry name" value="Coenzyme A diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35576" checksum="0D1382651897A990" modified="2016-10-05" version="1" fragment="single">SKAAIARLRAYKPPPFTIWDRLPLSRRAAVLILLFADRRGDLRVVVTMRASTLRSFSGQAAFPGGKADSLEETPFEIARREAWEEIGLPRDDSKIPRPFRIEHLCQLPFSLAKTALAVRPCVAFLHSDDNSGSKASSVEESMIPRLDAKEVAAVFSAPFHNFLSEKDELREGDTIPGKRTDWYKGVWTDFNDTRWKMHNFFVPINNQKVSKPKIRESGQASIAEHLDEEEEEKMRYRVWGMTARMLVDAARVAYDEEPEFDHNRHIGDEDMIETLYNLGRLQEKVPGGPDLTDGDMKAVHAARAAQAAKTAAPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRG6</accession>
    <name>A0A194XRG6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_575759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076999.1">
        <property type="nucleotide sequence ID" value="XM_018208806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRG6"/>
    <dbReference type="STRING" id="149040.A0A194XRG6"/>
    <dbReference type="GeneID" id="28818532"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575759"/>
    <dbReference type="InParanoid" id="A0A194XRG6"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="473"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ22644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="619" mass="69480" checksum="058E462512485D24" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRY2</accession>
    <name>A0A194XRY2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_714272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076837.1">
        <property type="nucleotide sequence ID" value="XM_018218118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRY2"/>
    <dbReference type="GeneID" id="28827844"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714272"/>
    <dbReference type="InParanoid" id="A0A194XRY2"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="13685" checksum="2DED6BF8FCD0A64F" modified="2016-10-05" version="1">MSEIKAILCPEACAFPPGLFHHAKIHNGVVYCAGQVGADVEGKLVSEDVAAQTEKTLSNLKAILESAGSGLERVLKVNIYMPEQADYAAMNEIYKKLMPDPKPPRACVFVKGLPGGAKVEIEFIAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS66</accession>
    <name>A0A194XS66_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_679813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077341.1">
        <property type="nucleotide sequence ID" value="XM_018213942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS66"/>
    <dbReference type="STRING" id="149040.A0A194XS66"/>
    <dbReference type="GeneID" id="28823668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679813"/>
    <dbReference type="InParanoid" id="A0A194XS66"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF226">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="231" mass="25679" checksum="46BED027C2CC960F" modified="2016-10-05" version="1">MFLSAAGGTITTALSALFFYLSRNQDAYQKLAHEIRSNFTSSTEIRGTALAGCTYLRACIDEAMRLSPPAPGILWRDLAPDDDESQPFVVDGHVVPPHTIVGVNTYSLHHNEDYFPDAFAYRPERWLASSDFSPEEKKVMREAFAPFSVGPRGCAGKAMAYLECSLVMARTLWYFDFESTAGELGEVGAGKVGLEDGRERRGEFQLYDTFSASHDGPYLTFVARGDFWKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSZ4</accession>
    <name>A0A194XSZ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_777051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077621.1">
        <property type="nucleotide sequence ID" value="XM_018222098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSZ4"/>
    <dbReference type="STRING" id="149040.A0A194XSZ4"/>
    <dbReference type="GeneID" id="28831824"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777051"/>
    <dbReference type="InParanoid" id="A0A194XSZ4"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="38029" checksum="350C962D2AE82FD0" modified="2016-10-05" version="1">MANLFGQPYLHLTVSNLRNMLMLVSLDFDEANDTKEDLFALAQDFESSLPARTRQQIEDSLYDLMYRRRSLKAKESEFQALLTRISAREDDVDDEEVEVEEMRICAVCEDELPIANFPYLNITNSCTHEADVCLTCLREHIRVQMLDRTVDRLSCPGGPLCAERLTSEDVQRWATAELFVAYSDNALTELFRLDPNFHHCLGPDCGAGQIIEQQDAILMVCEACAFMTCIRHQLPWHTGQTCEQYDLQLMENARHEQENAASGDEIRVNTRPCRQCGTRICRTVGCDHMTCRLCNCEFCWGCGRLWATARALHGITCTMPTAWHIVDDDPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUA5</accession>
    <name>A0A194XUA5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_744173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078076.1">
        <property type="nucleotide sequence ID" value="XM_018221025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUA5"/>
    <dbReference type="GeneID" id="28830751"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744173"/>
    <dbReference type="InParanoid" id="A0A194XUA5"/>
    <dbReference type="OrthoDB" id="3563678at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7908" evidence="1">
        <location>
            <begin position="164"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="32631" checksum="7101758D2AE6A37B" modified="2016-10-05" version="1">MTSPSSLGTSSTSLVQVSPVQKTSSVTSSITKLLIPFESTSAGNRKVPGAASTLVSEETEAASHGAILQVTTATSSQMIVPAIPGSSTEVIVVGDFTSVPTMKAPVLQEPSTGVIAHIASQEQSNAQAPSLEASPNGIVPTATSAHVVVPAVSTSGIILQIMPLGVHKRQSSNTYLVPKSPFGELICDSSITFTLESGQLSTSNGGHLSTTNGATWMAFQALSSILAINTEFTIDRNRYLVWLNDAFVGGQALFCEEQSGQIDILFQGSNDANDVSYPGYGTTCAPVSLMIVQDTHYLHFPSFAIEYSCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUT2</accession>
    <name>A0A194XUT2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_679324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213847.1"/>
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    <dbReference type="FunCoup" id="A0A194XUT2">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUT2"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_679324"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:anaphase-promoting complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000033">
        <property type="entry name" value="Anaphase-promoting complex subunit ApcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
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    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="564"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="912" mass="102515" checksum="6DE73AC3101A10BC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV06</accession>
    <name>A0A194XV06_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_185482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KUJ23542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205657.1"/>
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    <dbReference type="OrthoDB" id="5396681at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="6">
        <location>
            <begin position="120"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="443" mass="50542" checksum="9420089D527D39E5" modified="2016-10-05" version="1">MSRVDRGVCRWRRKGCLRQKRKCCPDEHGMHTRRRTVSNCSDLDEYLSERNDFHTRFISIAAINSIRPLKITEAGVYSILNHHNVGSQFLDLLFSFATRKNESEAGPGNLSIKNFPDGSYEIQYRFSYAEEIVGKSSSTWAIRQTGVYHRHVPNGSGNIWILLHPRPDSTVHTRLQDCALEWEGRSGSLDEWEMTHILILSSYFDDWRWYLKYLNGEVELMAAIAISYDFSVTGDHTKGTEIMQRLHALLMKISPITPRLRSTIGTVTALKTLYETLRRKTLYTERHSVKILDELKTYEAHAEGHLATVALLEKKIQETVGLLAVALNLRGQSTALSINRNIFSLTKDTVDDSATVRVVTVVTLIYLPASFVTSLLGMNLFTFQTSPGSGFKVSRQFWVFLLITIPLTFVTVGSWMFVARRRQKQKRVDRRRQASVGGESEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV49</accession>
    <name>A0A194XV49_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_572632</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078259.1">
        <property type="nucleotide sequence ID" value="XM_018208650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV49"/>
    <dbReference type="GeneID" id="28818376"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572632"/>
    <dbReference type="InParanoid" id="A0A194XV49"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="771" mass="85162" checksum="E28BF4BEB35DCD1E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX05</accession>
    <name>A0A194XX05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078949.1">
        <property type="nucleotide sequence ID" value="XM_018219175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX05"/>
    <dbReference type="GeneID" id="28828901"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727614"/>
    <dbReference type="InParanoid" id="A0A194XX05"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="40491" checksum="F950295C4CCE5DD3" modified="2016-10-05" version="1">MPSERTQQQSMQEPCQTLEYATLVCQLYQSLFPHQESWRFQLRIILSIMDQFLGPDIPQEQRKSNNEVLIESGLIEEILKFLDYFRDRERFLQSQCPVELGECETLDQVIQVLHRPKILESIMLVKSFVFLDDRLHFPSIWRRLWGGSVEALHMNMQSITQPQAREGEENRDDGNDNWKSSLPSHPKPSGFDRDVWLLREPDTFDILGSILYPGVFDAYISDNRQASRDASCSDPSRNTQMEWLPSERQGSTERPHLVDGTELCLPIRRRSSPTRQGSRRRRASNRALTRGPPLGRHHRRILAAQAAQQTQSRVIFLRALIRRTELERRSRTGHLKGKDRSMVQYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1F1</accession>
    <name>A0A132B1F1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_603691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947451">
        <property type="protein sequence ID" value="KUJ06205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060560.1">
        <property type="nucleotide sequence ID" value="XM_018210318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1F1"/>
    <dbReference type="GeneID" id="28820044"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603691"/>
    <dbReference type="InParanoid" id="A0A132B1F1"/>
    <dbReference type="OrthoDB" id="5514950at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10742" checksum="9AF566953C4ACC29" modified="2016-05-11" version="1" fragment="single">NPAKCTVVTSRSDLPSLLVYGQEIPRAESYTYLGFPVTANGIDFQQYLDQRIQAAVGRAHWLGVQSNSWGPAHRLRIYKQFLTPIFEYSAPLVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2R3</accession>
    <name>A0A132B2R3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_769627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060684.1">
        <property type="nucleotide sequence ID" value="XM_018221828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2R3"/>
    <dbReference type="GeneID" id="28831554"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769627"/>
    <dbReference type="InParanoid" id="A0A132B2R3"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32679" checksum="4CB99FD72A034D16" modified="2016-05-11" version="1">MACPMSIHRLPKLEDSPIFDRTSILAISSVATLLLIAGVCCFALLHRATSTKVRILFTWHLFGALTHLTLEVSYLYNVFFTSMSKLDATYTWGLHSTPFTPVNVSFLGNSKRLYGSFYGTSLTARFWQEYAKADTRWGGSDLTITGVEMIMVFVVAPLSLYVCHLLYKNEHTKAWFWMAVIGVGELYGGFVVLLPEWLSGSPHLDNSSFLTLWVYLVFPKGLRIFFSLWILTSAYFALTSSAQYSNQGLSSGITESKQLSTVERSGKVVQRQKSCLSQQQINFSNHLISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Y2</accession>
    <name>A0A132B3Y2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_678316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061396.1">
        <property type="nucleotide sequence ID" value="XM_018213735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Y2"/>
    <dbReference type="GeneID" id="28823461"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678316"/>
    <dbReference type="InParanoid" id="A0A132B3Y2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="242" mass="27757" checksum="48D1BC8386A37F45" modified="2016-05-11" version="1">MASGVESFESFQEDIDDSSFYDATYALLTQDLFGGSGPNEICSTENVNDKLEPYQKHNNASPTTYSSKDVEGTNTLNCPPADSITSPHEASVSFSSSSSLPPSLPSLPTLALEQLEAQPRPLKSKGSRSADSKLYERINKWIEEQIAQFNKLYTWIKKDLELQREDWIRNIYAKSLTNGDFRYAIMREHPRHPLHSKSPRHIVRFMVANDITESLWQEDPRLRKLHQELKLDEELFQGWFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B555</accession>
    <name>A0A132B555_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_357405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061901.1">
        <property type="nucleotide sequence ID" value="XM_018206972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B555"/>
    <dbReference type="GeneID" id="28816698"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_357405"/>
    <dbReference type="InParanoid" id="A0A132B555"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41724" checksum="569C21FABF65DBB8" modified="2016-05-11" version="1">MSSRLFTNAPLPPLPIGGIPLQPVDSAVVVHPPGYMAPPTLGRARARRRCLPRWLSFLRGSPIERFLCTGWNGIIIIAVIAIATLVALLVLAAVNLTNSTNKMTATCLKLDPLGNCCKYLDMEGNCFIHNVTDDDTTLAKMKHSLDDADLVAADVLGHDTTYANMKRSLGDDNALIADVLSHDTTFVNIKCSVDNDADLAADVLAHDTTLTNMKRSCDDDDTLVADVLDHDPAVAKVKRSLDDADFAAKPTPFFVPSPNPNVQHAMNGPTTTTNGFRSPSSTLAPTTFLALATPTVALPVLFVYATSLLHLQQKLTNRQSEHHDMMGSHLRELTENLAQPLNKEAVELANDFIEEMLAEMGAYEGFLEGLEDDVVDLVRELDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5C6</accession>
    <name>A0A132B5C6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_356914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061896.1">
        <property type="nucleotide sequence ID" value="XM_018206969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5C6"/>
    <dbReference type="GeneID" id="28816695"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_356914"/>
    <dbReference type="InParanoid" id="A0A132B5C6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="22507" checksum="402910B94E6F16FA" modified="2016-05-11" version="1">MKTIPFRSPFSPDLTFGLITKKRLSNCCLHLSTLEEIVAADELTTKRHLTTPTLSTNKFHLRNKTKRISRQHQAPYRSGILDSVTRDRELNTSSSGVPSVVAEEEIEGVMGRFIITSVELVDLSCNNEALGNASYIHSQRLIYSYESHSPSTTHTSHDLCLQFMPYPHAQFTSMLNASPICTTCIYNQHLIYPLDLYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5J6</accession>
    <name>A0A132B5J6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_725999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061519.1">
        <property type="nucleotide sequence ID" value="XM_018219018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5J6"/>
    <dbReference type="GeneID" id="28828744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725999"/>
    <dbReference type="InParanoid" id="A0A132B5J6"/>
    <dbReference type="OrthoDB" id="3546297at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="341" mass="37757" checksum="79B0880B11C29B2C" modified="2016-05-11" version="1">MAAVTTPDRADRLESSGFSSHRYLSLAMTMDKDEGTAIFRRFGDLNMLNLLSLQAELMKLRNDLQESCVQNATEAEDYARGYLNAYSLPSRANEEETEASIEKKEKEKLQLLISIRNKLREYNSALLEAAQIRNLEPPDKDDIEYLRAWLRPEFRGKDLKDSDRACWDPENNDDLVSIKSQLEKGNKIITNFKFAVQIIQYKLWGYRKMTSNQANSNVIHFGKEEGRLSRTKIERKTAFVSRLVMALFGGIALIVPTIIMAKHQDLNFSLGTTSIATLLFAIILAFGARDSTGKDVLAATAAYAAVLVVFIGTGLASTTTTSTISGAGITSASSTSAQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5T7</accession>
    <name>A0A132B5T7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_677557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062130.1">
        <property type="nucleotide sequence ID" value="XM_018213685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5T7"/>
    <dbReference type="GeneID" id="28823411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677557"/>
    <dbReference type="InParanoid" id="A0A132B5T7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17611" checksum="30498049B9DBA26C" modified="2016-05-11" version="1">MDLSLDSDIHGYNRPCPHRAPHMRDLVHYRIKTETRQRMRLDDQYQPEEITDFSKSMIYQFATSALAITLIEPPSCCDMSPLSNPTHLHTCTATSLLRRKDVPVYRDEIVKQTAELHIYPISGGRMTAMIRAEKSVIDQFEKSKYRSRIGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5T8</accession>
    <name>A0A132B5T8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_538821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062125.1">
        <property type="nucleotide sequence ID" value="XM_018208137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5T8"/>
    <dbReference type="GeneID" id="28817863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_538821"/>
    <dbReference type="InParanoid" id="A0A132B5T8"/>
    <dbReference type="OrthoDB" id="5428966at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12660" checksum="592F3088C4DAB065" modified="2016-05-11" version="1" fragment="single">FNILHVAARYGHIGLAKFILQQSLIDDIDCRAHSQDTALVFAAFYHYPSSAEIVRLLLSAGADVDAPGQRNKRPIHWAADVGNIEVIKVLLEHHCSLVPDDTGMTPQWRALKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B606</accession>
    <name>A0A132B606_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_702265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062200.1">
        <property type="nucleotide sequence ID" value="XM_018217243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B606"/>
    <dbReference type="GeneID" id="28826969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702265"/>
    <dbReference type="InParanoid" id="A0A132B606"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="349" mass="35896" checksum="1A71BE0F7410F0DD" modified="2016-05-11" version="1">MELPTNRAAWLIKADTPLEIREAPMPTPGPGELVVHNAVVGINHVDNWMLEAGVFVKQWPTVIGNDVAGTVYAVGSDVERFKKGDRVIGHGMTLVTGRPEDGAFALYTIVSADRAAILPNSIAFKDGVVLPLAVGAAACALFNQQPGEVMPGVPLALLGLPYPSVQRPVPSSGKTLVVYGGSSTVGAVVTQLATAVGVTVITITGAHNFGLSQRCGAVEVIDHKDSAITEKVGAAVAKYGGFIGIIVAIATPDTYPTALAILAALGGGHLACTHPPPADVPANVKASMIFSVNDASIPLFRDYLTPALEAGKLLCVPPPIVAGKGLESIQDALKKAKAGLSAAKMVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6U5</accession>
    <name>A0A132B6U5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_691407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062490.1">
        <property type="nucleotide sequence ID" value="XM_018216313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6U5"/>
    <dbReference type="GeneID" id="28826039"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691407"/>
    <dbReference type="InParanoid" id="A0A132B6U5"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="18952" checksum="9EF55024F5210158" modified="2016-05-11" version="1">MSIPTPSKVTGGCLCGGVRYQIDFSSDHDWKRGSSTCQCTQCRKNCGSLVYNFHTVTASEITWTSQSTYAEYTSSPGCYRSFCNKCGSPIAWTDRSVNTDVGLAVGTIDEEFLVGERDSEDKPKGGFGLALANPEARHYYIRNEIPGVTDGIAATGTKFWEGSKEGAMRRDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Y4</accession>
    <name>A0A132B6Y4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_337063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062527.1">
        <property type="nucleotide sequence ID" value="XM_018206828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Y4"/>
    <dbReference type="GeneID" id="28816554"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_337063"/>
    <dbReference type="InParanoid" id="A0A132B6Y4"/>
    <dbReference type="OrthoDB" id="10545823at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="543" mass="62398" checksum="7DCF7E52EBB2C599" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B761</accession>
    <name>A0A132B761_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_338869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062601.1">
        <property type="nucleotide sequence ID" value="XM_018206845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B761"/>
    <dbReference type="GeneID" id="28816571"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_338869"/>
    <dbReference type="InParanoid" id="A0A132B761"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12481" checksum="06B8DCE1F20AD325" modified="2016-05-11" version="1">MHMLSYQLRYSPHSEQGECCGYSVDLLKANGKFDEKPLDANVEASIVAAKEGEEALLKDSRSDACKIFVCATKVFDNSPIVFRSYNNAKASGSVSGINIWLPIVSTPSLILRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B786</accession>
    <name>A0A132B786_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_725178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B786"/>
    <dbReference type="STRING" id="149040.A0A132B786"/>
    <dbReference type="GeneID" id="28828685"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725178"/>
    <dbReference type="InParanoid" id="A0A132B786"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="231" mass="24953" checksum="DD24A60525622B2A" modified="2016-05-11" version="1">MQLETKYHILLLGGTGICGLIFVRAALEAGHTLTVYVRTPSKIPAALFANPRLSVIQGELGDEGGLRKAAGCGADVFLSLAGPTMGKREGTPITNAFKTLFPLLLSNGTTKRVLVLSTASYSAPEDTASFKWWVAVNCYVKVIGGDTYEEIVGFTEETVALGEKIKWTAFRVPLLRGEDLNESKGEVNAAYVGDKKGRDGLFLDRGRLARWILNELDEGKWIGCCPLVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B800</accession>
    <name>A0A132B800_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_691395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062474.1">
        <property type="nucleotide sequence ID" value="XM_018216309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B800"/>
    <dbReference type="GeneID" id="28826035"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691395"/>
    <dbReference type="InParanoid" id="A0A132B800"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="619" mass="68553" checksum="7137CD4CC09DF7BA" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8D3</accession>
    <name>A0A132B8D3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_322773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063021.1">
        <property type="nucleotide sequence ID" value="XM_018206727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8D3"/>
    <dbReference type="GeneID" id="28816453"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_322773"/>
    <dbReference type="InParanoid" id="A0A132B8D3"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="250"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="47741" checksum="D5A3ED4FD697FBA9" modified="2016-05-11" version="1">MSSLKRITALSDEISKNSKTVTDYLSEKGLEAASFDVDGLAEFPINPSDEEAFKARLALIAATRELHDLSLGPKEGLRYLAWDSANQLSLQAVYEFKLAEAVPLSGSISYQDLSEKVNVPMLNLRRVIRHAMTNHIFHEPEKGFVAHTRTSRLLLEDLPLSSWVGFMTNDLWLPIANVVKAMKKWPGSGESNETSVNLAYGTDTNWFDWLQEDKDLAKRYGLAMQAHGGGEGFAISHTVNGYPWGELGEATVVDMGGSQGYVSFAIAEQFPKLNFIVQDTAGMRVSSTIAKVPEHLTDRVQLTTHDFFTPQTVDAQVYFFRWIFHGFSEKYCIKILQALTPALKTGAKIVINDGTLPEPGTAGYVEEKSMRTMDLFMQITVNAREREVDDWAELFKQADERYKFLKAWKPEKSRMWFIEAEWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8J5</accession>
    <name>A0A132B8J5_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_764047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063077.1">
        <property type="nucleotide sequence ID" value="XM_018221620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8J5"/>
    <dbReference type="GeneID" id="28831346"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764047"/>
    <dbReference type="InParanoid" id="A0A132B8J5"/>
    <dbReference type="OrthoDB" id="10649199at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="236" mass="27410" checksum="B18F979978207332" modified="2016-05-11" version="1">MAPIDKTLRRRVFGAQFNKMDISPRLKRTYADAFFHLNKVEFSESGICTIRTKIRKIDFDQAYYCAPFMLYEISRRMKYHCNFIVVLDRGQADLEIFEFDDRGHIILYKQIECARTFDNDQDARRELCNIALHWLLHEGPLERSQDRDGKGIPLDYYDTIEEDSGSEDELNSTQSLAADFLEGSAAVEVETIGPANIVELKKGQLGLEKDTASKLKRAERTEYYDTMDLDEERFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B911</accession>
    <name>A0A132B911_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063216.1">
        <property type="nucleotide sequence ID" value="XM_018216178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B911"/>
    <dbReference type="GeneID" id="28825904"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690832"/>
    <dbReference type="InParanoid" id="A0A132B911"/>
    <dbReference type="OrthoDB" id="3530497at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288007" evidence="1">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="22756" checksum="E30041EB87DF5398" modified="2016-05-11" version="1">MFSFSYVFALANFMSSMVTCTLFEQQRLFSSIDVTSKPSIPGGSTFEYCSESDPENDIFIIEKIKWDPNPPTISREQKLLVFGTFSQRIPSSANGTGTVYIPEWHNPESPASNYTETSPFCTWPNFVYQTDEARGLHKVCDGAVGANFSAPEAGSAILVSEDILFWPLPEGEYGLKLDMLMLKDEEGEGGERIFCFEGKVDLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9D2</accession>
    <name>A0A132B9D2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_741303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063360.1">
        <property type="nucleotide sequence ID" value="XM_018220690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9D2"/>
    <dbReference type="GeneID" id="28830416"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741303"/>
    <dbReference type="InParanoid" id="A0A132B9D2"/>
    <dbReference type="OrthoDB" id="3543689at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="381"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="884" mass="100210" checksum="137FEEF0BF21B303" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9X9</accession>
    <name>A0A132B9X9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_741841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062832.1">
        <property type="nucleotide sequence ID" value="XM_018220762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9X9"/>
    <dbReference type="GeneID" id="28830488"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741841"/>
    <dbReference type="InParanoid" id="A0A132B9X9"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33264" checksum="AA92C7DD5B550E6C" modified="2016-05-11" version="1">MTFRRIAIAGASGFLGRKIIEQLSLVVDITRLTILTRSKQPVKTSNNSILSFVSIVSYEDTEALANVLQGHDLLISTIAGAAAGMIDAILAEAAVMAGVRRFMPSEYTVDVLHPHSIAFAGSTILATKLANARKLQTLASEGKIEYTTLVTGAFLDFWLSKAVKGIVDLDSHTVMLYDGGEHQVTGCTTDFIAQCVRAVVTMPEDATRNSRIRIAEVQFSGKQLLGILEEVTGEQWTGVHKDTDALVTESLIALKGGDTRSFYVGQILKLGFDGEGSCYFEEGLTHGEDEVQRLSLNDIVRHSLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA19</accession>
    <name>A0A132BA19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_763676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063448.1">
        <property type="nucleotide sequence ID" value="XM_018221604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA19"/>
    <dbReference type="GeneID" id="28831330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_763676"/>
    <dbReference type="InParanoid" id="A0A132BA19"/>
    <dbReference type="OrthoDB" id="3541187at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="408" mass="47106" checksum="CBECFE94BB3528E2" modified="2016-05-11" version="1" fragment="single">VDFVRLYFRTLTALFLRHNAPFTNHIALYTVDPFHKYNCNLLPPMPPNIPTKSPPKNWLDIKKLRLEWINTRMPLPGQDFLYRVAEEVLRRMGPDTYIVALAGIEDWGDVMENETFHTSIWHYNGAFDDCMEYGVAEVLHARDYETYKPIARKYFNFPGAMASSLTTCLLHERRECWKVLQKHPLFSYFKNAYHIKLCLVKFFNTRYTSLFADITGAHITLDSNGVYGSTTSLRLPDEYPEFSDVSNDFYTAKFRLGYQTEEQSKKEKEEARLDWRKMTDDMCFRWSCGSEEKLFVLNAMIWLRLLHAANPNQQSLKEMLVLLFGEEDIEDEDDDVKAEEKDDDAISDVSSCGGVKDAGDEDKNVKVASESDVKTFLGYGDSRTRPATNSEGLTWDGILEGVKAHYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA86</accession>
    <name>A0A132BA86_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_320909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063518.1">
        <property type="nucleotide sequence ID" value="XM_018206714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA86"/>
    <dbReference type="GeneID" id="28816440"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_320909"/>
    <dbReference type="InParanoid" id="A0A132BA86"/>
    <dbReference type="OrthoDB" id="3526850at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058645">
        <property type="entry name" value="NTF2-like_dom_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26534">
        <property type="entry name" value="NTF2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288016" description="NTF2-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="164" mass="17774" checksum="46E75012F855BB84" modified="2016-05-11" version="1">MVSLSSLLLPLLASTVLAAPCLDDNEAIHIAKKWLDIWSSGTITKESQLTTLVTPDIQSYDGTYGQATVGIDALFASCTYVDPLVKDVVQVPIFIFHSCDQIAARWTYNALSTGVGSTVKANTPIFFHGTELLHVDLQSRLIYNSTSSADWVLLATQLGQTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAL3</accession>
    <name>A0A132BAL3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_788279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063773.1">
        <property type="nucleotide sequence ID" value="XM_018223156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAL3"/>
    <dbReference type="GeneID" id="28832882"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788279"/>
    <dbReference type="InParanoid" id="A0A132BAL3"/>
    <dbReference type="OrthoDB" id="3473589at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="331" mass="38665" checksum="AC67B02A00167F9D" modified="2016-05-11" version="1">MEEFEFFPELPKELRLLIWETALGLEEPRIVSIQQKCLKKTIGAWEKENNAIWPPLDRRTHPRQAGRAERTGYASKAQLEEQGRRARGWISKLSGRSYKKASLMGVACNTPPPSLLLVSHEARDVALKRYSLILACPQSNPETYFDFTLDTLYMTWRNFNRYRLKPTSPAPQLDVWNGFIDFDNLFKVERLAIQVISSRKTHFDEKRVAEVLRVFPSVKQLSLVAQHYHDSNLSALEQSDLCLTDDPIDVEEAFNAYHNFEYNEDEFHSYYGFWTLPVIQESTLLPRKTRAELEELQKDCERTIGEIDERIAEAEEGMWDNEYDMYEPNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAW3</accession>
    <name>A0A132BAW3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gaba permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_741124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063768.1">
        <property type="nucleotide sequence ID" value="XM_018220668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAW3"/>
    <dbReference type="FunCoup" id="A0A132BAW3">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="GeneID" id="28830394"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741124"/>
    <dbReference type="InParanoid" id="A0A132BAW3"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="559" mass="60837" checksum="3BCB25B1D9CC647A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBC1</accession>
    <name>A0A132BBC1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064077.1">
        <property type="nucleotide sequence ID" value="XM_018220631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBC1"/>
    <dbReference type="GeneID" id="28830357"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740795"/>
    <dbReference type="InParanoid" id="A0A132BBC1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="253" mass="27405" checksum="74CC3120696C235A" modified="2016-05-11" version="1">MASNDKTIVLITGGNGGVGYLTAEALAASSPNYHVIITSRNLEKGEKALEDLQKSQPKESFSLVKLDVTDHQTITDAASQVSKEFGHIDVLINNAGIISKATLLINQLREVFETNTFGPAIVTESFLPLLEKSKDARLIYVTSDLGSITERSDPSGKYYKLPAVSYRMSKSALNMLAMCHHAELGPKGVKVWTFNPGYVVTNLSGTGEAGRQERIKNGAGDAKESAEGILKLVDGRRDQDVGKFVNKDGIHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBZ3</accession>
    <name>A0A132BBZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">High nitrogen upregulated cytochrome P450 monooxygenase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_700990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064290.1">
        <property type="nucleotide sequence ID" value="XM_018217160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBZ3"/>
    <dbReference type="STRING" id="149040.A0A132BBZ3"/>
    <dbReference type="GeneID" id="28826886"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700990"/>
    <dbReference type="InParanoid" id="A0A132BBZ3"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF112">
        <property type="entry name" value="L-ORNITHINE-N5-MONOOXYGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ09935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="309" mass="34490" checksum="C92EC1E17CD99B21" modified="2016-05-11" version="1">MADLAFAHNAGMQDGTRQNDYMGFIHKYMATVVMLGALRPLHALLPYLPKTADIEAHRQRGLALLSSRLKLGKTRKDLFTHLLDADATFTSEQLYSNSSMIIIAGTDTTSSTMTQLFRALALNPQIQKKMQCEIDEFCAEGKHISVESTKGFGYINAVISESLRLFNPVPGGIYAATPPSGLTIPAFGEKGNETFVPGNVQVMIPHLALMTDPRYFPKGDEFIPERWTGEWNAGVLDRRAYIPFGYGVHSCVGKQLALNEMRLAVASIVKEWDIVLGEQYDEKVWKYGIKDYHTVKVGELWAKFVPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC24</accession>
    <name>A0A132BC24_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_741117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063759.1">
        <property type="nucleotide sequence ID" value="XM_018220667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC24"/>
    <dbReference type="GeneID" id="28830393"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741117"/>
    <dbReference type="InParanoid" id="A0A132BC24"/>
    <dbReference type="OrthoDB" id="5318428at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15970" checksum="853ABB75E0B1271D" modified="2016-05-11" version="1">MANLTHFNPKASSKPYMGLFSNCTIVPPNTALAYISTQWAADPSTGELVEGAAGDYTKQSKIVWTNLVETLKELGAQMKDVVHTTVSFSEFNDDIGKAVVEAWVSVMPDEWKQDMFKPSLTFNGVSIFHRPGVVYAVDLVVAVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCF4</accession>
    <name>A0A132BCF4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_270009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064465.1">
        <property type="nucleotide sequence ID" value="XM_018206358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCF4"/>
    <dbReference type="GeneID" id="28816084"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_270009"/>
    <dbReference type="InParanoid" id="A0A132BCF4"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37430" checksum="5A0F6CF198DA4B9F" modified="2016-05-11" version="1">MPSTPEPPAPAAAASSRCRLCGKSFQNKASTGRHERYCRNRRACPPPPRRKSCLHCIRAKSRCDSCVPTCEPCQRRGKSCIYTSESLSPTAREGQSRLSATRSKPQNQAPRSLVAPRELSQGASLRSGLFITFEACPSSVAPRTSTPLSSEMREFTSTKHGEASDGASGQLGMPFTTGSSELRPSFSSHLLRPKRRKTGQMELISKLISQMLRSFPERRMNEVSCPPFIHRSAFQRSSSENPIIICQSITRQFSAREIHEDASLWDAIASEQERIYDLRGSLDRSLHLASAQAITMYLLMLATEAESVLTHHPHASVTLLFTLGRFSRYSIKYIPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD22</accession>
    <name>A0A132BD22_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_761136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063912.1">
        <property type="nucleotide sequence ID" value="XM_018221535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD22"/>
    <dbReference type="GeneID" id="28831261"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_761136"/>
    <dbReference type="InParanoid" id="A0A132BD22"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="349" mass="39606" checksum="EB646D290CB00758" modified="2016-05-11" version="1">MTRITPRTCLWPLAGSLSLTFALSIGLTFRSNHHCFAGTCGEWLFPLQARLHVVIWYCFLGISVTILALRAFQPRLRKRLQKPLFEGKIPIIGKQIGLGGLLILLWIISLYGIIVGVWWIRLEAYFTQRGLEGGVLNGNKRLAAIALTGHLCDVTMGMAILPISRHSALASFFKLSVATTLTFHMITAYTLFALVVTHGFLYVSWLPVFEALPATLRMVYPVLNPTYFYRECWPGNQSSLGVWRASLIFTGITTSFIMLLIFITTLPVIRLRHFNVFYFTHLLGIVAIITICLHASTMFYCTAPGLTMWALDWAMRLYELWAPLDGRIKDMGKGWYWYELSFSNTILHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDH9</accession>
    <name>A0A132BDH9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_561121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064840.1">
        <property type="nucleotide sequence ID" value="XM_018208455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDH9"/>
    <dbReference type="GeneID" id="28818181"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_561121"/>
    <dbReference type="InParanoid" id="A0A132BDH9"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="144" mass="15984" checksum="D644C4C26C64F810" modified="2016-05-11" version="1" fragment="single">EATAEAFFKSPYFAVVGASGNEAKFGHIVFTWYIDENLPVTPINPSTRLITVHDIKYPTTKDVLSLPHPSETALSFLTQTDQTRKALEEAKEVGVQAVWFQHGSVTPEDFEYAQREFKIVVGGHVGTDAHDGWCVLVHGKKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE96</accession>
    <name>A0A132BE96_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_656420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064928.1">
        <property type="nucleotide sequence ID" value="XM_018212385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE96"/>
    <dbReference type="STRING" id="149040.A0A132BE96"/>
    <dbReference type="GeneID" id="28822111"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656420"/>
    <dbReference type="InParanoid" id="A0A132BE96"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="30109" checksum="574E784BF8F80431" modified="2016-05-11" version="1">MATNGTRKSIRAVNPPVADSVFQSFRLDGKTVIITGGSGGIGYEVARGLAEAGANIAIWYSSSKTAQKQAATIAKDFNVKTATYKVQVENYAEVEEAVASVVKDFGRLDVMIANAGIPSNAGGLDGTVSDWDHVRAVDFDGAYYCARAAGLVFKAQGYGKCIFTASMSGYAANVPQEQSCLQGWCCKFTAQWEKIHLSKSLAVEWAKWGGRVNSVSPGYIDTEISGDCPFEMKEAWYDLTPLRRDADPRELKGVYLYLASDASSYTTGADFAIDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEL0</accession>
    <name>A0A132BEL0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_760926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064472.1">
        <property type="nucleotide sequence ID" value="XM_018221530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEL0"/>
    <dbReference type="STRING" id="149040.A0A132BEL0"/>
    <dbReference type="GeneID" id="28831256"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760926"/>
    <dbReference type="InParanoid" id="A0A132BEL0"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288138" evidence="3">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="336" mass="37090" checksum="249156A148D9679D" modified="2016-05-11" version="1">MYASVFTIFTIATTASFAIAAPQVKERSNTTSASCGTVSQRKSWVDLTNDEKTAYLDAEVCLMSLPATAGFPGAQTRWDDLQFAHINSTNVVHDVGGFLPWHRLYMYTHITMLQNECNYTGVQPYWEELLDSSNLTASSIFDPVYGFGGDGNGTDECITDGPFANVTLHLGPIYEVTDHCISRSLNDNAIKWANQTYLDIVFAAQNYSAAWPLFSSWPHTAGHAAIAGVMLDVTCSPGDPIFFLHHTNLDRLWWEWQAMDLTTRLTDMDGQNVPTAEYIAEMGIYNVTDSWLDYDGDNGGNVTTLNHTLSVLGLVPNATIADVMDIQGGLLCYEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRG3</accession>
    <name>A0A194WRG3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_244547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064958.1">
        <property type="nucleotide sequence ID" value="XM_018206147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRG3"/>
    <dbReference type="GeneID" id="28815873"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_244547"/>
    <dbReference type="InParanoid" id="A0A194WRG3"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41149" checksum="1C0C299218182BCD" modified="2016-10-05" version="1">MSSPWKKKQPEVVVDAVLKRAEVGKIGRKLKARLALAQYKAARGWEDLTLDTIEPKVEEELRQKRPLSSGDIFSDSSSSTNSVVSEFRYSGSRTLMSSPLKAPAIFSDQVGSRSGSGSSTGLRKRNFHHSFEHPSSPTSARKRFRSSPTAGRSVNAGRTSWKDSQLAQSSPIKPKKHTHFTTSSGPGLSFFSGSDEVHSTNFAATSDDEENMLPAHSFDIRSSPPRTPSPPRNRGSLGHRKDKTGKLGEEGADLLLYLATSPSPANPNRARMAPPSTPPPKTLALPSSMMTTPGGGGSLLAGFGGPVTPSQGFDFSDFVNITPSPAQGAWPKTPRTAKTPLTVARRRLTFDNFSHPGSSPNLREGSSGSTKHTGLGMQLGGDLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WS64</accession>
    <name>A0A194WS64_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_626405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065171.1">
        <property type="nucleotide sequence ID" value="XM_018211105.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WS64"/>
    <dbReference type="STRING" id="149040.A0A194WS64"/>
    <dbReference type="GeneID" id="28820831"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626405"/>
    <dbReference type="InParanoid" id="A0A194WS64"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="587" mass="67042" checksum="44610B9DB2ECF980" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU24</accession>
    <name>A0A194WU24_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065811.1">
        <property type="nucleotide sequence ID" value="XM_018220414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU24"/>
    <dbReference type="GeneID" id="28830140"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738892"/>
    <dbReference type="InParanoid" id="A0A194WU24"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267442" evidence="2">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="158" mass="17551" checksum="3BB8A3B096B6EDB2" modified="2016-10-05" version="1">MKVLPFCVFCLAPIALALPATPPTALKEIAALRNLVREPVELRTLRILAPDSAESQFDWRDASHESLPPRNRYAEDSQVLSTENQYFRAREASDSQLRSPENQHLGAPEAFKPRSRSSRKAIPSRDSPKKEPAAQADREGSRRTVDLDVFGGRGAIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUK5</accession>
    <name>A0A194WUK5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_786907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065647.1">
        <property type="nucleotide sequence ID" value="XM_018223027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUK5"/>
    <dbReference type="STRING" id="149040.A0A194WUK5"/>
    <dbReference type="GeneID" id="28832753"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786907"/>
    <dbReference type="InParanoid" id="A0A194WUK5"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="32874" checksum="4FEB83EC2E5B37D4" modified="2016-10-05" version="1">MSSWQPDSPVERPDGSLVCKAHGLVVCGVCTVDYSFMLENLNNSPFYDVVPRPTREQTLNPVPGVFPTRFRPSAPTDIPSSLFTYGNIFDHHRFVRRTDSKEILIFTDGACLDNGKENPRAGCGFVFRPQTTNQPVKGGSFEFRLESRGPSGDALPQTSNRAELRAVIAALQYRAWDGEGWNRIVIATDSEYTVKGATEWIKNWQSNGWRTSNREPVKNKDSWELLLKEVRFLKEKGVEVVFWWIPRELNGEADAAAKRGAQEGEQQQFVRYCGVYTGIGGEMMSLMMPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUP6</accession>
    <name>A0A194WUP6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_689209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065692.1">
        <property type="nucleotide sequence ID" value="XM_018215864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUP6"/>
    <dbReference type="GeneID" id="28825590"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689209"/>
    <dbReference type="InParanoid" id="A0A194WUP6"/>
    <dbReference type="OrthoDB" id="5213892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267475" description="Zn(2)-C6 fungal-type domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="645" mass="72105" checksum="4092AAC86EFC0614" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUZ3</accession>
    <name>A0A194WUZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_594774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066146.1">
        <property type="nucleotide sequence ID" value="XM_018209821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUZ3"/>
    <dbReference type="STRING" id="149040.A0A194WUZ3"/>
    <dbReference type="GeneID" id="28819547"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594774"/>
    <dbReference type="InParanoid" id="A0A194WUZ3"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="27795" checksum="56002903D76E5D06" modified="2016-10-05" version="1">MENAAHIVAPCGNHTQTIILLHGRDSIASEFAEEFLESQASDDRTLPEIFPTTRWVFPTSKIRNSARFGAPMSQWFDMWSVENHLEKNEIQIDGLRESVKEILDLIRTEAVLISPDRIILGGISQGCATAIHTLLYGGIRLGGFIGLSSWLPFEPEITTTMADNMAWSIDGSTFVLETPVFLSHSRDDDIIPIANGKKLSTTLEKLEMVVSWKQYEDGGHWVNEPQGVDDIVSFIHSCRRVQLDEEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWH7</accession>
    <name>A0A194WWH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutathione degradosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_688081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066686.1">
        <property type="nucleotide sequence ID" value="XM_018215634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWH7"/>
    <dbReference type="FunCoup" id="A0A194WWH7">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWH7"/>
    <dbReference type="GeneID" id="28825360"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688081"/>
    <dbReference type="InParanoid" id="A0A194WWH7"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111656" checksum="BC4EDDC2281C488B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWM3</accession>
    <name>A0A194WWM3_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_221591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWM3"/>
    <dbReference type="GeneID" id="28815674"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_221591"/>
    <dbReference type="InParanoid" id="A0A194WWM3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="153" mass="16668" checksum="5A9E35E4708C74CF" modified="2016-10-05" version="1">MIILVPRLRAAPQVPLSHALEVVSHVCSFRTACDQDRRNDLVRIMKAKKSPIDNFSLGTRDHGSIVEHSTASSRMIVPHSIPLPFLFHPLPPPSLPHRASPPGMLFHINELITMFIFPAARGPSEGAGETIPPCQDHASGLSQSARSHAVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ91</accession>
    <name>A0A194WZ91_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">Amino acid transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_756113</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28831089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756113"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="580" mass="63535" checksum="2E7D33D0C2F9E311" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0C0</accession>
    <name>A0A194X0C0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067672.1">
        <property type="nucleotide sequence ID" value="XM_018209659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0C0"/>
    <dbReference type="GeneID" id="28819385"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591536"/>
    <dbReference type="InParanoid" id="A0A194X0C0"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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            <end position="532"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="552" mass="60962" checksum="3D5F8EB9F0AC7072" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0C5</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068001.1">
        <property type="nucleotide sequence ID" value="XM_018215415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0C5"/>
    <dbReference type="STRING" id="149040.A0A194X0C5"/>
    <dbReference type="GeneID" id="28825141"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687053"/>
    <dbReference type="InParanoid" id="A0A194X0C5"/>
    <dbReference type="OrthoDB" id="5408102at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="547" mass="61276" checksum="8BCE148A24E3A8EC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X155</accession>
    <name>A0A194X155_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068278.1">
        <property type="nucleotide sequence ID" value="XM_018215460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X155"/>
    <dbReference type="STRING" id="149040.A0A194X155"/>
    <dbReference type="GeneID" id="28825186"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687257"/>
    <dbReference type="InParanoid" id="A0A194X155"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="87"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="47627" checksum="8C6B4EDB62F147F1" modified="2016-10-05" version="1">MDSPVQALPQRLAIGMVPPTLQLQPEPHQQTTTPKVHGIQASLLIPGRGSPIKNAILIIHEKTITWVGPTASLPPKYVSIPTIHVPILLPGLWDVHTHYFGVVSSTAGYDSLLGPAALAGARTVRDLKNTLFAGFTSVRELGGYAGEISPAVEDGSIVGPHIYSAIAPISMTAGHGDIHNLPIGTVLDACAHGLPFAVCDGVPDCIRTVRLMIRRGAKCIKVCATGGVFSLLDSPQDTQFSPEELKAMVDEAARAKRVVAAHCHGKEGILAAINAGVKTFEHGSYMDEECIKLMLEKDIIYCPTASVVEGGARNADDMPPINRKKILETAVHARHAYRLAIKNGVKIALGTDQASSTPGNYNSHGANGKEIFYAVKAGMTPLQAIEACTAISPETLGPHMAPKSGQLKEGYDADMIALSENPLENIDLLSEPDNITHVWKDGMLSKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1D3</accession>
    <name>A0A194X1D3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_544709</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068358.1">
        <property type="nucleotide sequence ID" value="XM_018208221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1D3"/>
    <dbReference type="GeneID" id="28817947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_544709"/>
    <dbReference type="InParanoid" id="A0A194X1D3"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ14003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="69" mass="7168" checksum="AA95F08197219277" modified="2016-10-05" version="1" fragment="single">LPAISSWPSCGQLCFNNLIGQYSSLGCSSPDPSCLCSNVNFGYGIRDCSNGACGTDIASTVIAYETAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1D7</accession>
    <name>A0A194X1D7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_561879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068366.1">
        <property type="nucleotide sequence ID" value="XM_018208468.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194X1D7"/>
    <dbReference type="GeneID" id="28818194"/>
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    <dbReference type="InParanoid" id="A0A194X1D7"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="67" mass="8026" checksum="28759BF0F4F3B06F" modified="2016-10-05" version="1" fragment="single">PPQSPDLNPIKGIWAIIKQRLRRRVFDSEEDMKEALQEEWDKITMQEIRDRIADMPRRCAQLKKYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X243</accession>
    <name>A0A194X243_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm to vacuole targeting protein-like protein Vps64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_687242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068267.1">
        <property type="nucleotide sequence ID" value="XM_018215458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X243"/>
    <dbReference type="STRING" id="149040.A0A194X243"/>
    <dbReference type="GeneID" id="28825184"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687242"/>
    <dbReference type="InParanoid" id="A0A194X243"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000127">
        <property type="entry name" value="Uncharacterized protein C3H7.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="761" mass="81670" checksum="F957B44C3BE37549" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2M4</accession>
    <name>A0A194X2M4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_649993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068624.1">
        <property type="nucleotide sequence ID" value="XM_018212087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2M4"/>
    <dbReference type="GeneID" id="28821813"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649993"/>
    <dbReference type="InParanoid" id="A0A194X2M4"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267753" description="Expansin-like EG45 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="3">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="420" mass="42126" checksum="372F9CCCB6CD1E6C" modified="2016-10-05" version="1">MHFTTAVAASAVLALATASSLAGQATFYGGNVAGGACSFSTYTLPSGIFGTALSDSNWDTAANCGACVSVTGPSGNSITAMIVDECPGCGTNHLDLFPDAFAALANPTTGVIDVTWEYVDCPITSPLEVHNKEGVSAYWFSMQVVNANQAVSSLEVSTDGGSTWQSTTRQTYNFFEQSSGFGTTTVDIKVTSDSGDVVIVNNVDVSSGASTTASGNFGSSGSSSVATSSTVAAVVASSSSTPVAAFMESTSVFETTTSSSAQVTGSAGGVFQEVSSSSSDATTKHTTLSSTTTLYKTITVPKSTSTSTTSSPTITASFNSSLVAYSTPVANSSTALPSGYSISVLTISMCKPTVLYSVFPVPSSSSTSSPSPAATGVASYSANITLSAPTSTPTAFTGSASSMQVSLVLVGFAGLITFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2P0</accession>
    <name>A0A194X2P0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative bilirubin oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_736333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068644.1">
        <property type="nucleotide sequence ID" value="XM_018220113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2P0"/>
    <dbReference type="GeneID" id="28829839"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736333"/>
    <dbReference type="InParanoid" id="A0A194X2P0"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13889">
        <property type="entry name" value="CuRO_3_BOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267835" evidence="4">
        <location>
            <begin position="22"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="374"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="599" mass="66740" checksum="B85240E1DB3F2D6A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2T0</accession>
    <name>A0A194X2T0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_784290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068684.1">
        <property type="nucleotide sequence ID" value="XM_018222771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2T0"/>
    <dbReference type="GeneID" id="28832497"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784290"/>
    <dbReference type="InParanoid" id="A0A194X2T0"/>
    <dbReference type="OrthoDB" id="5420706at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="13500" checksum="F6A3C7C95A5EF164" modified="2016-10-05" version="1">MSKFLGAIQDVWGKMTCVGGDGSSGDDNSKIWNTRDGSSGGGNNSNCRNCKNCSNCRDCSNCTNCSNCTDCSDCKNCSNCKSCEGLVDCSNCSNCQNCIGCTNCRNCSGLKNRHNASNEHGDETSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X367</accession>
    <name>A0A194X367_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_117730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068981.1">
        <property type="nucleotide sequence ID" value="XM_018205119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X367"/>
    <dbReference type="STRING" id="149040.A0A194X367"/>
    <dbReference type="GeneID" id="28814845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_117730"/>
    <dbReference type="InParanoid" id="A0A194X367"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ14626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="49979" checksum="BE2006E7B527B93B" modified="2016-10-05" version="1">MQPNSTVLCGGFGLCGVPDTLIDEVINKKDITGLTAVSNNAGTDTSGLGKLLKTKQIKKMIASYIGENKTFEKMYLTGEVELELTPQGTLAERCASGGKGIPAFYTPAAFGTVVQTGELPLQNNPDGTPKVYSYPKDVKVFDGKQYLLEESIKGDYAFVKAYKADKLGNCQFRLTANNFNGAMGRNAKMTIVEAEHIVEPGEIPPEAVHLPGIYVKRVIQSTTPKNIEKYTFAKDPNDPEAKAALGSGDTAAKRERIVRRAAKEFKNGMYANLGIGMPMLAPAFVGPDVEVQLQSENGILGLGPYPVKGKEDADLINAGKETVTLKPGAAVFGSEESFGMIRSGRVNLTILGAMQVSGNGDLANWMLPGKIKGFGGAMDLVSNPEKTKVVVTMEHTDKKGNAKIVKQCAFPLTGKACVSMIITELGVFEVDIATGLTLTEIADGVTVDQIKSKTEAPFKVADDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3K9</accession>
    <name>A0A194X3K9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_117356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068969.1">
        <property type="nucleotide sequence ID" value="XM_018205117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3K9"/>
    <dbReference type="GeneID" id="28814843"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_117356"/>
    <dbReference type="InParanoid" id="A0A194X3K9"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="86" mass="9706" checksum="0A0EA0AA1CE421D0" modified="2016-10-05" version="1">MLLLSVDDARNQTESIVDLVRFSYSNVNTRDTEVGQDIDSLRRMVIHFVACVFEKIGMNESFLVLMEEGGPLARDLASMLAKRITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X434</accession>
    <name>A0A194X434_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_122665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069169.1">
        <property type="nucleotide sequence ID" value="XM_018205166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X434"/>
    <dbReference type="GeneID" id="28814892"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_122665"/>
    <dbReference type="InParanoid" id="A0A194X434"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="86" mass="9919" checksum="4D4135EB91E05E31" modified="2016-10-05" version="1">MLSFFSPSLHIYYYIPTYLSCNIISCLPFLSINKGKDKSKNANRKQGCFLGEGCAAEWVGTQTPLPRGQRTNKREEGERDEWRKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X468</accession>
    <name>A0A194X468_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_620215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069326.1">
        <property type="nucleotide sequence ID" value="XM_018210904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X468"/>
    <dbReference type="GeneID" id="28820630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620215"/>
    <dbReference type="InParanoid" id="A0A194X468"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="33932" checksum="964A9E5FE68CB675" modified="2016-10-05" version="1" fragment="single">MVLLTMTASIVEALEKIQSLRVASSLEEKQYNAEEDETKEHEIHGQEQPAENTTDPQKISAENTREATSTEPTLKNAKIGNPISHGQVVDLSNQMKEQGIEPCRLELLLKGSRIYIPPPPPKPEPTSEYKALMARLRREEEARSYERMTNPPPPAETFAQRFPMASAAHAFPSSYQSIETSDPDDDGTTYADVDRQMTLIFNVLISIVACAAGIWITARWWSTPMRLALSMGGSMLVGVAEVVVYAGYIRRVGEAKTQERKVKEVKQVVNTWVVGADEQESVQADHVLLTPNEDNKDAKARRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4A2</accession>
    <name>A0A194X4A2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_736065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069360.1">
        <property type="nucleotide sequence ID" value="XM_018220082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4A2"/>
    <dbReference type="GeneID" id="28829808"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736065"/>
    <dbReference type="InParanoid" id="A0A194X4A2"/>
    <dbReference type="OrthoDB" id="3562104at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="53530" checksum="964826C85FC10AD1" modified="2016-10-05" version="1">MSFPVGEIGIVITIAKLLYKLQQDYASAPDEATNLSNELEHLQHCIAPLQKSPPQSAIDRKRLETVLKPVLNLLEQINEVCDRYSDLKSGRRIWDRATFPKTKVHALQKQIHSQFTGLTVFNMGLQNKTLAKISDILEEIGGVLSQRFANNENGWELVVAELERRGLRLSKEAAATCKEPIKQHLEALSEVEQAESQLMVYENTTIGPDDAVDEDIAVGPPTPAHLSSLVCPGAAALQSGKQDVIKQSKNHLLQHFGASKYEIICRHCSFHGFQDEPLKSKDKPYNTPLFFAPRQEALKPSSVEYYFEVHRRNRSEHDGIWYHTIFFWKCHIKAREPLLHISARYQCVFCPLANAYSNTYSRDSLLEHIRKHHVQTPPPRELREKFNVWIDDKNALFLKDEGRMQEQPFDIMIPKAYGRTDYLKAERAKHQADIVEAANAQSRARTKQTSDANIREQVKELHWVAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5M5</accession>
    <name>A0A194X5M5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_735582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069830.1">
        <property type="nucleotide sequence ID" value="XM_018220031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5M5"/>
    <dbReference type="GeneID" id="28829757"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735582"/>
    <dbReference type="InParanoid" id="A0A194X5M5"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25324" checksum="0B56778AFB8E62E4" modified="2016-10-05" version="1">MSTATSPTAPRTLYITLQYLRRDASGNKYHWGLYATSDTPPRGTLFHATDAGRQPLDLYYEERKVENPTKSKSMTVCVKIGDVSSTTAIHRCVSTVPLMSRSRIPAGERQWTCRVYVKEALNALHNAQLLSLPASVGSIERACLAVADAYLPYRLSRERPGVYNDFSWLRRGSTSRTIPMEVDPTLYYPSEMEVDSSGRYRSTRSYGSLMDVDSSGRYASSQSYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X690</accession>
    <name>A0A194X690_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_557355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070050.1">
        <property type="nucleotide sequence ID" value="XM_018208395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X690"/>
    <dbReference type="STRING" id="149040.A0A194X690"/>
    <dbReference type="GeneID" id="28818121"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_557355"/>
    <dbReference type="InParanoid" id="A0A194X690"/>
    <dbReference type="OrthoDB" id="3519926at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="25519" checksum="9AEC333189C1CC71" modified="2016-10-05" version="1" fragment="single">ELQLSCSVKTLKRRCKEAGYYSCICYQKPYLTKTQANARWLWGIAHMFWTIWEWSQILYSDEVTFQVGGKKCKQRCIRNKKERCYGYKSPLINIYGTGKSGAFTQTDYLAQVLKPYIQDFLAAFAAVLGPGKTPQFMEDGNSAHGHKTTSNICATWRTSMGITLFPHPAVSPDMNPIEKCWRRIKQALHRRLRQPTTEVQMVVAVLEEWDKIPQEWINGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6M8</accession>
    <name>A0A194X6M8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_685679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070089.1">
        <property type="nucleotide sequence ID" value="XM_018215131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6M8"/>
    <dbReference type="GeneID" id="28824857"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685679"/>
    <dbReference type="InParanoid" id="A0A194X6M8"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16866" checksum="52CEB65C3D660DC0" modified="2016-10-05" version="1">MDTPSAPEPQPSAIRYILGFLLIGIAWGFTTPFIRAAARTHSPPPHPILDSPSVKKSWLKSKVYGAFFGVVDLLRNPRYAIPLVINLTGSVWFFLLIGKAELSLTVPITNSLAFLFTVLGDWWVDRKVISRDTWIGMALSLGGIALCVQSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6T4</accession>
    <name>A0A194X6T4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Triose-phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_783648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069872.1">
        <property type="nucleotide sequence ID" value="XM_018222705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6T4"/>
    <dbReference type="GeneID" id="28832431"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783648"/>
    <dbReference type="InParanoid" id="A0A194X6T4"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="42"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="401" mass="44425" checksum="4F58AEB6DE7278A3" modified="2016-10-05" version="1">MSEEKVRLSGENARAADSPILPTVNPNLEKKQEPKGNGINPAVYVIVWISLSSSVILFNKWILSTLNFHYPILLTSWHLVFATIMTQIMARTTTLLDGRKTVKMTGRVYLRAIVPIGLFFSLSLICGNLTYLYLSVSFIQMIKAFTPVAVLIAGWILQIEPVDLKKLGNVSMIVVGVALASYGELDFVLTGFLYQVGGIIFEAIRICLVQTLLHGSEFKMDPLVSLYYFAPVCAVMNLTVAVLWEVPKVTMTEVYAVGLWTFFANACCAFLLNVSVVFLIGKTSGLVLTLCGVLKDVLLVAASMLIWGTKISGLQAFGYSIALMGMIYYKLGQKELKPFIAEMSRRWAEFGANKPVLRKLLIFTFFIGSIMFLFNQLAPTYAPDYDTKSLIDASKTYLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7F1</accession>
    <name>A0A194X7F1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_719742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070458.1">
        <property type="nucleotide sequence ID" value="XM_018218517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7F1"/>
    <dbReference type="GeneID" id="28828243"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719742"/>
    <dbReference type="InParanoid" id="A0A194X7F1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267984" description="Beta-xylanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="14">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="389" mass="41438" checksum="3763B45729F3E16A" modified="2016-10-05" version="1">MQINQALKLSFLLPSVYAQLHGAAKTAGLLYFGTETESVSFGDAAYQAALKGNDDFGQITPGNSMKWDAIQPAPNTFTFTAGDAIADLAATNNQLLRCHNLVWHEQLPDWVSGGNWTAASLTQVLQNHITTEVTHYKGKCYAWDVVNEALNDNGTFGNDVFFNVLGSDYIKIAFQAAAAADPAAKLYYNDFGTEFPGVKSTAAQGIVKMLKDANIKIDGVGFQGHFTVGGTPSVATQVTNMEAFTALGVEVAITELDIRMTLPQTDAMLAQQKTDYQTTAAACLATKNCVGVTVWDFDDKYSWVPSTFPGTGSADIMTANVTKKPAYFGVLQAFTGTAANSTTTMPSMPNMTVTAPSLRASSSGASALDKPGMILGMLLSLIFAMFIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7I4</accession>
    <name>A0A194X7I4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L30e-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_698010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070414.1">
        <property type="nucleotide sequence ID" value="XM_018216948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7I4"/>
    <dbReference type="STRING" id="149040.A0A194X7I4"/>
    <dbReference type="GeneID" id="28826674"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698010"/>
    <dbReference type="InParanoid" id="A0A194X7I4"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ16059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="9715" checksum="6D405F22D0DBA1B4" modified="2016-10-05" version="1">MAPTKKAKKTSDSINSRLALVMKSGKVTLGLPCNKTLSSGKAKLVIIAGNTPPLRKSESLHAIELGTACGKLFRCSTMAVLDAGDSDILSGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X817</accession>
    <name>A0A194X817_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_79432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070661.1">
        <property type="nucleotide sequence ID" value="XM_018223408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X817"/>
    <dbReference type="GeneID" id="28833134"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_79432"/>
    <dbReference type="InParanoid" id="A0A194X817"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="155" mass="17443" checksum="A5F3B5B75B77BE40" modified="2016-10-05" version="1">MILSISTVVLASSRTSEPLLLFPNYYFVSSHIREPGFRKKHQNLLRSPSLLRIIVATIIIIQHVSHKKAYSFPSTATLLSEPFCRGYPIPTTHPSAPSTLITLCTLLTRPKTLLPTLPYQTTPAIMTLSSSIFLPSLPRSLDLRSMERETSHSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X908</accession>
    <name>A0A194X908_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_87973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070954.1">
        <property type="nucleotide sequence ID" value="XM_018223480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X908"/>
    <dbReference type="GeneID" id="28833206"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_87973"/>
    <dbReference type="InParanoid" id="A0A194X908"/>
    <dbReference type="OrthoDB" id="4586224at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="441" mass="49124" checksum="AA303B3FC42B3868" modified="2016-10-05" version="1">MAWIVFLSFQSNDIIFSDWVTLLTLCLAPLIAHIAAGVPPPIYLHSNRPSWHDRICHYNPTSILWRYLAIADRRLRAKSWNTLDLAATNAIFWDGHKWDGSEDMIQRSRDFCIRGPSHHHIDPLSMSTIVTLVVTLQGVQALYSLVHGTQGLYAYTVALNTIFFPLATLGLLRLPAALWLTTDYAYRHNEDWESDTPEMGLHPNLGVRSNSALVRPTTNSLDAPIVPNRFRSHRGWLSIAVRGFYLIMITGLLVLCIYMLTAPVGTGDAEFSATNLTLNLTFLFFLAFSTGTIGAYILLGRCKTTIIPCITATWYKIYTGILFAAMFTVFIIACLETRRTPCGRFTTYPKTIANDWGVCGESTYAEIAAEHDTTSSLPVSRTNGTQLSYAAIYFNSTYGIAMNAGEDEIVVIAIDGWCKIDSEITLADISMFKPTNFSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X961</accession>
    <name>A0A194X961_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_684766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071014.1">
        <property type="nucleotide sequence ID" value="XM_018214944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X961"/>
    <dbReference type="STRING" id="149040.A0A194X961"/>
    <dbReference type="GeneID" id="28824670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684766"/>
    <dbReference type="InParanoid" id="A0A194X961"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="71220" checksum="AE08A78CF7F0D124" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9B4</accession>
    <name>A0A194X9B4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_63897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071115.1">
        <property type="nucleotide sequence ID" value="XM_018211598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9B4"/>
    <dbReference type="STRING" id="149040.A0A194X9B4"/>
    <dbReference type="GeneID" id="28821324"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_63897"/>
    <dbReference type="InParanoid" id="A0A194X9B4"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="182" mass="20090" checksum="948E59BBADBC9420" modified="2016-10-05" version="1">MSNPTPAQRLESILSRNEEYAETYKAPGKLMDGIEKRKKSGAKSMVIIACADPRVHPMEYLDLNRGEAAILRNAGGRTQGVIRSLLVLDALGDVGTVVVVHHTDCGTSQFGEKGEDEFQHRIEEKHPGLAEDHHGCWGAINDPYKTIVEDVDFLKSFPTIAENMEVFGLVLDTFTGKLKQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA89</accession>
    <name>A0A194XA89_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_669511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071443.1">
        <property type="nucleotide sequence ID" value="XM_018213102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA89"/>
    <dbReference type="GeneID" id="28822828"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669511"/>
    <dbReference type="InParanoid" id="A0A194XA89"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46917" checksum="7F5181EDACA6EC3F" modified="2016-10-05" version="1">MPGCYKETVCQLCGVSFAITRFRRAEEDSSKAWAYYGSDYSDSPICGVGSGCTALPRDDSENGEHLAGPGCVCTSGYSGYRISVEEMRGCRSVVVILKKEEDWEEESDDQEFEKEGGYFLTGVGDGSPDEAPLEGLTPVRHGVEGVWIWNTVEDVDEEMGLPMHPSCFEIWKRISIEKTGKVDLHDIWAWRQLEGSYEAFFERFPRHPAVRQGKDQWWEHKPGAEWLAANPIDIPGLNLLINSCYREKYNVNRSVHPVWRRPFPTTYSSSTTPNDPFWKLPQELRFAILEPLSGRDIANLRLVTPAYRDLPVILFRAVILSDFPWLWEIRELEVGTTMWYTLYMSIKFGFGQLMGVRNRRRVWQDVEEIWRRVERYKREGRLEVGLLKRWMHVVKTRRERLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBG7</accession>
    <name>A0A194XBG7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_684536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071861.1">
        <property type="nucleotide sequence ID" value="XM_018214902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBG7"/>
    <dbReference type="FunCoup" id="A0A194XBG7">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBG7"/>
    <dbReference type="GeneID" id="28824628"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684536"/>
    <dbReference type="InParanoid" id="A0A194XBG7"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="728" mass="81861" checksum="90D278D2D87B53DF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC86</accession>
    <name>A0A194XC86_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">NCS1 nucleoside transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_707171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072126.1">
        <property type="nucleotide sequence ID" value="XM_018217582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC86"/>
    <dbReference type="FunCoup" id="A0A194XC86">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="28827308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707171"/>
    <dbReference type="InParanoid" id="A0A194XC86"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="385"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="553" mass="61075" checksum="E89F43B317D84543" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEP1</accession>
    <name>A0A194XEP1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_717199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072971.1">
        <property type="nucleotide sequence ID" value="XM_018218332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEP1"/>
    <dbReference type="GeneID" id="28828058"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717199"/>
    <dbReference type="InParanoid" id="A0A194XEP1"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="418" mass="45607" checksum="8F87DFD551462E42" modified="2016-10-05" version="1">MGHNGVAVNDVAKVKRGVSTVIYTVQTTGTFYYDGTYTLITAAPTNFEVSETTATNSLSSTTASSTSSSSTTSFSSASLSSTSSSPLSSISVARSRPSHSSTSSSGISAGETAGISIGTFIAGLALALLGFWFCMNRRKHSQGHRSRKSHDNNTYDGDKQGISQTSTREETLLDPVDDSTLKSTMAKLNSFIDQHVLSHYHEDPIQISQRQLAQAIIDRRSKNALGDMSPDELASLMIAPATRLHAIRHFVAWVILSHTGLDAQPDACLLPRYIVTFYNAFPPIERQAGCEEAFECALSQWKHLSAFLLVPNRSFREDPKVDETQVRSAIDVNLKAFNHVLAPFVINGPVNNHDWEKNLRAIVFAGAELGLTLFSQQSAWVFDWKHHGRSEAVVVFPALLEKVKGRSKLRIVSEAVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEV1</accession>
    <name>A0A194XEV1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_706369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073031.1">
        <property type="nucleotide sequence ID" value="XM_018217520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEV1"/>
    <dbReference type="STRING" id="149040.A0A194XEV1"/>
    <dbReference type="GeneID" id="28827246"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706369"/>
    <dbReference type="InParanoid" id="A0A194XEV1"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268152" description="Dipeptidyl-peptidase V" evidence="7">
        <location>
            <begin position="25"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="509"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="741" mass="81058" checksum="AEC46BFF39848811" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFP3</accession>
    <name>A0A194XFP3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073304.1">
        <property type="nucleotide sequence ID" value="XM_018214758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFP3"/>
    <dbReference type="GeneID" id="28824484"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683777"/>
    <dbReference type="InParanoid" id="A0A194XFP3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="250" mass="27554" checksum="46D698916C9C37BD" modified="2016-10-05" version="1">MTTSKPTIILLPGAWHPPTVFAPLINKLTRHGYKCIPLPLQATDQSEAVPPLQKDLDALHQAASRCINDGEDVMVVAHSWSGLIAGGGLDGLGKVEREKEGKKNGVVRIAYLCAFCPVENVSLIDAFGGKEPEFYNVQKPWVKVTGPENLFYNDLPPDQQAYWASQLLPHSYATKFQGTKTVAWKKVPCSYLICENDNAIPSFVQEAMVKKCQEEGAEMEAERIKSGHSPFLSKVDETADFLRRAAGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG22</accession>
    <name>A0A194XG22_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_683079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073500.1">
        <property type="nucleotide sequence ID" value="XM_018214631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG22"/>
    <dbReference type="STRING" id="149040.A0A194XG22"/>
    <dbReference type="GeneID" id="28824357"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683079"/>
    <dbReference type="InParanoid" id="A0A194XG22"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="35"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46595" checksum="E3CF2644BA87E6E0" modified="2016-10-05" version="1">MPPLIASQMSTLLTRRKSLSSHRTLTTFPPSSKDFSSNDFLSLSTSPLLRSHFLTELSSHPNFRLGSSGSRLLDGNSTYAEELESFIANFHKCEAALLFNSGFDANEGFFASVPQDGDVVVWDEMIHASVREGIKLSRAAKSVSFKHCDVDDLRRVLRDVKRGDRNVFIAVESLYSMDGDLAPLKQILDVVEREVGERGLVVVDEAHSTGVYGEKGRGLCCELGVEERVFARLHTFGKALGCNGAAILCSKLTREYLINYARPLIYTTAMGFPSLAAIKVVYSLMKEGKTDPLRIHLNELIIHMYQQLQTLHPYTTSSDLLQIPSEMPRSPIFALLMPDPRSLAKYCQEAGFVVRAIMPPTVPIGTQRVRVCLHAGNSREDVERLVGTIRNWLMLQRREVRERGCEGMREVFVKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG47</accession>
    <name>A0A194XG47_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_642082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073503.1">
        <property type="nucleotide sequence ID" value="XM_018211739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG47"/>
    <dbReference type="STRING" id="149040.A0A194XG47"/>
    <dbReference type="GeneID" id="28821465"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642082"/>
    <dbReference type="InParanoid" id="A0A194XG47"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF53">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="70"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="36728" checksum="B660B8E0A167D518" modified="2016-10-05" version="1">MSFQHTLDGLLAKGKAKLNEFTHPEQQAPPQNYNQNYNYNYNARPPPPPINYASKPTNFAPPIPPRQAAPYWKADFNPSTPISSIFVQETGAHGWGNNESQNYTTSPTNSFFTPSHQLVLRAISSPSSPENKYTSARLYTHQTLSRPRGCLTAVLFAPCADGIWPAFWLLPQEPFKWPDDGEVDIFESWNGDRVNRSCLHWGHFNGEDWDKHRVVETRIEDMGERPHVFAFAWEQGEEGRGGRCVWYVDGRAVMKATIPQGTRRMSEWRVILNVAMGGNVCGGRLPREGSYDFVVHELKIEEQPVGGWGQFGVDWEKAMEGKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG57</accession>
    <name>A0A194XG57_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_478251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073481.1">
        <property type="nucleotide sequence ID" value="XM_018207824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG57"/>
    <dbReference type="GeneID" id="28817550"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_478251"/>
    <dbReference type="InParanoid" id="A0A194XG57"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF10">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="188"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="47637" checksum="D9219A1A88CC7629" modified="2016-10-05" version="1">MDSLNITIPYEEPEWNSAPAWRLPGWAEPVMVASILIGSMLITRRHGYKLFGRRRRSQGLLDDDIDSARSSDDLLSRDYMIAGDDVSEDSMSTMKYPPKKRSCCGTILYTPNSSRFADHLHSRIMQKFPFLMEMFYWIITYAFYRCTSLTAQAIFSKTGIWDVAQDHGLAILEFEQFSWLSFLWPVREQEVQQWFMHGHQTFLTVLNRSYALIHIPGTVGFIAWWYYVAPSFNTFAIVRRTMTLTNLIAFSIFILYPCMPPRLLPREYGFLDSVGHNKAESVWMSGKYVNSLAAMPSMHFGYSFCIGCTMFYHSGLFRKTLEPGESRKSKPWQLFYALFAIAYPCWILITIVATANHYYLDACIAFFVAIIAFMCNRIFLVFLPLEDLLLWCLRIEKPIPTTGDRARRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGC3</accession>
    <name>A0A194XGC3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_484618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073573.1">
        <property type="nucleotide sequence ID" value="XM_018207845.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XGC3"/>
    <dbReference type="GeneID" id="28817571"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_484618"/>
    <dbReference type="InParanoid" id="A0A194XGC3"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1442" mass="151310" checksum="477F6033A369DFD7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHF3</accession>
    <name>A0A194XHF3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_706239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073926.1">
        <property type="nucleotide sequence ID" value="XM_018217509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHF3"/>
    <dbReference type="STRING" id="149040.A0A194XHF3"/>
    <dbReference type="GeneID" id="28827235"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706239"/>
    <dbReference type="InParanoid" id="A0A194XHF3"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="308" mass="34680" checksum="24B74591857CD827" modified="2016-10-05" version="1">MAVEKRHKPIILVTHPRACSTAFERIFLTRAQDVVCVHEPFTGAFYFGPERLSDRALEIIEEAGADGKRILVKDFAKCIIPPDGEPSAIVPSLRHAKSEVNGNGRDMKLPETVQLNPTIIPSQTLRTFHFAFLIRSPRLSIPSLYKCSVPPKSALTGWHGFRSKDSGNRELRVFFDYLKGIGHIGRSNACAKETSTAEPDDICVVDADDLLADPERVIKAFCTSVDIPFEPYMICWDKTDDRQRAEALFKDWAPFHDIAIQSTSLMLRPSIDDLDPSVEFAEWVRMFGKMRHEPFSGVSRRILTTTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIV5</accession>
    <name>A0A194XIV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074399.1">
        <property type="nucleotide sequence ID" value="XM_018219557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIV5"/>
    <dbReference type="GeneID" id="28829283"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731283"/>
    <dbReference type="InParanoid" id="A0A194XIV5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="650" mass="73395" checksum="189DE524BD4AAC24" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJN7</accession>
    <name>A0A194XJN7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_695003</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074674.1">
        <property type="nucleotide sequence ID" value="XM_018216744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJN7"/>
    <dbReference type="FunCoup" id="A0A194XJN7">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJN7"/>
    <dbReference type="GeneID" id="28826470"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695003"/>
    <dbReference type="InParanoid" id="A0A194XJN7"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="127"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="16">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ20319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="626" mass="71000" checksum="FEE8E0F6AEF730D1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJN9</accession>
    <name>A0A194XJN9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Asp/Glu racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_682097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074701.1">
        <property type="nucleotide sequence ID" value="XM_018214440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJN9"/>
    <dbReference type="STRING" id="149040.A0A194XJN9"/>
    <dbReference type="GeneID" id="28824166"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682097"/>
    <dbReference type="InParanoid" id="A0A194XJN9"/>
    <dbReference type="OrthoDB" id="414270at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267:SF1">
        <property type="entry name" value="BLR3294 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27619" checksum="74F31F574218748F" modified="2016-10-05" version="1">MSSSSSPKRIRLGILTPSSNTALEPLTYELITVLNAHLPSTQITAHFSRFSVTKISLTPDGLAQFDLGPILAAAQLLADAQVDIIGWSGTSAGWLDFSQDLTLCAEIEKATGIKATTSILALNKALELWDVKKLGLVTPYLDDVQAKIVENYKGIGVEIGEKMERHLRVVKNTDIADIGEKTLDGMVGDVVGSGVDAVTTFCTNLIAAQRVRFWEEKYKVPVFDTVTTVVWDMLRECGVDAKGTKGWGMIFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJP2</accession>
    <name>A0A194XJP2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_579637</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074352.1">
        <property type="nucleotide sequence ID" value="XM_018209017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJP2"/>
    <dbReference type="FunCoup" id="A0A194XJP2">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJP2"/>
    <dbReference type="GeneID" id="28818743"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579637"/>
    <dbReference type="InParanoid" id="A0A194XJP2"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ19997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="57408" checksum="FF7ABE9EC0776C6A" modified="2016-10-05" version="1">MVADDKPASTFKYAQRPFYTTSNGCPVADPEAFQRVGSNGPLLLQDFHLIDLLAHFDRERIPERVVHAKGAGAYGEFVVTHDVSDLTSIDMLSSVGKKTPCVARFSTVGGEKGSPDTARDPRGFSIKFYTDEGNWDWVYNNTPIFFLRDPTKFPLFIHTQKRNPQTNLKDATMFWDYLSTHQEAVHQVMHLFSDRGTPYSYRHMNGYSGHTHKWTKPDGTFNYVQVHLKTDQGSKTFTNEEAGKMAAENPDHNTQDLFDSISKGDYPSWTVYVQVLSPEQAEKFRWNIFDLTKIWPQKEVPLRPFGKFTLNKNVENYFAEIEQVAFSPSHLVPGVEPSADPVLQSRLFSYPDTHRHRLGVNYQQIPVNAPLRAFNPYQRDGSMAVNGNYGANPNYPSSYRGLTYKPVKVTNDHEKWAGAAVSFLSEVTPEDYVQAKGLWDVLGKQTGQQDNFVNNVAGHLSAAKEDTRKRTYEMFGRVDKELGSRIATETEKLAPAPTSQAAGSAQARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK83</accession>
    <name>A0A194XK83_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_446376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074906.1">
        <property type="nucleotide sequence ID" value="XM_018207584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK83"/>
    <dbReference type="GeneID" id="28817310"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_446376"/>
    <dbReference type="InParanoid" id="A0A194XK83"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12745" checksum="F8F314615A538A3B" modified="2016-10-05" version="1">MACLLGCLLFSPRSLLLRFGGSMTCMFAVVFLVPERRAWVRRHSVRTDEQREQKQQMDDSESESDPVGCESESTKPPILTTTVANSTRRGRSVVSEYFSLAAMMAEQSAPSVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL28</accession>
    <name>A0A194XL28_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_456078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075191.1">
        <property type="nucleotide sequence ID" value="XM_018207637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL28"/>
    <dbReference type="STRING" id="149040.A0A194XL28"/>
    <dbReference type="GeneID" id="28817363"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_456078"/>
    <dbReference type="InParanoid" id="A0A194XL28"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49902" checksum="6D96AA07B23B9F78" modified="2016-10-05" version="1">MESSPSIQPRDIDLPISLLQLLSNSLVLYQTTPYLPVASLLALGATSKSFKDLIHNTPNVFRHLDLTRVKSAQFDIAAIDHGGEVWRNVQLDENVTEDDFYGGPLRGILNTLHRRNIIQDVQTLVLDGLSVTSDLVSDIILQERYNVRLLSIREVRNLNERKLQQALVFAVRPSRPANTPKLQGLYIFGAKDIAPVTRVSRHVNRYPPGVAPIDTVPSYGGVVYSQGAQIGAQWNQKSGDTLAEEMESGFDKWYQASGKVIAKPPSLEWASTMLVCQGLINFDAILCSGPRHSTTAVEIGPGSKVPWYRSSCSHLSSMVATHALGSCVGCGKAPEGFSKFGTSPLARFPLLAPPPLHSSASKAAKTPFSAYDDRLLVRCMDCLKGRFCENCHKWWCEDCYEVPDNSYIQVSPQHWEAIGNPPGGHLEKNVKVHMGLCVEDCLVAEMMSGAGSNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL31</accession>
    <name>A0A194XL31_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_444458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074837.1">
        <property type="nucleotide sequence ID" value="XM_018207571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL31"/>
    <dbReference type="STRING" id="149040.A0A194XL31"/>
    <dbReference type="GeneID" id="28817297"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_444458"/>
    <dbReference type="InParanoid" id="A0A194XL31"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="132"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="432" mass="47748" checksum="86A7EA1BD0BE39E8" modified="2016-10-05" version="1">MKTRGRPSKSATKPATETVEKDTSTNPKVQLEPDSANPPQLFILPKDKSKDARIVTLQNPRYLSDSRYLICPENGFYEFTKVAAPRTTPRSWLLSGSESNEVKEPDAKRRKHSGYVTKSAEMLVATAIDPLFVVLSVLAPLPTSKGSEAPKKLFLSGDDYIEKIATASPHFGGFSRIKSIRDLLEQRMAAVCDTVEAGDENMYRLNEEKLFGELLKKAKNMCETGLPPSMEEKLVRKALDIPVLSIKREDSSLHELVNEEAETPDTQTCVSTIESAGTSFSEASTAATSFSDDPIIESKPKAIPPINAPEGVVDLLRLRTALYFICAAYLAPHVTETVKKMAASSASVDFAPLEAHLAHLAKLRQDALASRSLGDFSRKRLAAEDIETRAEKKRKEDEEEKRKKANESRGVKALKKVNVTGMKKMSDFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLY6</accession>
    <name>A0A194XLY6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_665638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075548.1">
        <property type="nucleotide sequence ID" value="XM_018212855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLY6"/>
    <dbReference type="GeneID" id="28822581"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665638"/>
    <dbReference type="InParanoid" id="A0A194XLY6"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="40360" checksum="99AAC825CA1FDD57" modified="2016-10-05" version="1">MEMQDLDPKDVLEVKDIIGILEAWRHVGGTVVRFRPIKEARQKILTSKTRARHPILLLTSEELIRDVSNKFFLFFSEEIVLFRMASKVPPGLEHFSRLNQAIWFHQPNTVSSTEPALILLVGWMDATPRHMAKYAAGYEKLYPSARILIITTTQIDAAFRTHTANLNRIKPALNVLYTLPPSAKLLVHFFSNGGGFTTTMIAKAYKERMGRTLPVTAMILDSSPGRATYEATVRAFSVALPNNIILRTIGNLILRIFFVLYKLGYLLQGKMDLVDQARMDLNDKSIFDTDAPRMYIYSVADNMVAWQAVEEHGDEAQSLGYTIDREKFLESGHAAHLLVDADRYWATVKRLWGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMM3</accession>
    <name>A0A194XMM3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075377.1">
        <property type="nucleotide sequence ID" value="XM_018219412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMM3"/>
    <dbReference type="GeneID" id="28829138"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729824"/>
    <dbReference type="InParanoid" id="A0A194XMM3"/>
    <dbReference type="OrthoDB" id="10432845at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="135" mass="14851" checksum="F15448471B3F947B" modified="2016-10-05" version="1">MEHDSFFAPKVWDFAYPNGHAPPPTSPVLKAIDKPCFMHSETPSTVSSRRESDSSSSSSSSSCSETNPSTANQPRGLTSMPAWARNLPKEVFGGQKDGFVLFPTRSVPRVNERRGGIRRPGHPVLKLEIGERDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMS0</accession>
    <name>A0A194XMS0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_577669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075808.1">
        <property type="nucleotide sequence ID" value="XM_018208909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMS0"/>
    <dbReference type="GeneID" id="28818635"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577669"/>
    <dbReference type="InParanoid" id="A0A194XMS0"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="491" mass="54702" checksum="3B1E4156EDB3E252" modified="2016-10-05" version="1">MPKSKQFLKEPKKKSKHATPVPTNSDEYLAAGVDFEEAGEKWRGGDAVKSTRFFVRALDCYEEGLKKFPDSFDLAYNNCRTGLQYEITQHPKIVENLPGTLLELLQTALDSSRYALKLDPEDADALFTLASLLTDFAETKVSNNPSDKLQEALWLFERCLKRQVGTFKEENAALGDLAPKDVDMGEGDSAAGPPFPTKEEAWARVVEPTTKEILLETIVAKLETLSKLAEETDPRDGDSISYISDYYKDTIRRKYLKPLCEATSTDSSSFPDTLKLAIANYQCAVANLSYSARRIDLQQYEQVVQTAYNTLKPSSDPQELPSNPQVLCDYAESIIAFQNAVKELGLNHNPYLTQRWLALTEALKSLTVAGAMKDVKHREQIQLMRGDVEMMRFQLGEGPGQLAASQKNREALLGNSKKFYDGSRRISINNGAKEREIEARIKLDVVDAFIGDNTTLLEAKATLESFEAVLTEAISDGVVTKEQLLRLGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN20</accession>
    <name>A0A194XN20_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_681777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075527.1">
        <property type="nucleotide sequence ID" value="XM_018214365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN20"/>
    <dbReference type="FunCoup" id="A0A194XN20">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XN20"/>
    <dbReference type="GeneID" id="28824091"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681777"/>
    <dbReference type="InParanoid" id="A0A194XN20"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="190" mass="21932" checksum="2853ADE94B9239D5" modified="2016-10-05" version="1">MTSLRPFHATDVFKFNPTNLDPLTETYDLNFYFSYLARWPSLFNLATSPSGTISAYIMGKLESSPSYYITSAHYLPFHAHITALTVAPHARRLGLARVLSQGLEEKGEEYDAWFVDLFVRKSNRIAQALYKGMGYSVFRVVKGYYSDDPNDESADGEDAWDMRKPLRRDVERKHVRSDGEKWEVMPEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNQ9</accession>
    <name>A0A194XNQ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_714901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076225.1">
        <property type="nucleotide sequence ID" value="XM_018218163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNQ9"/>
    <dbReference type="GeneID" id="28827889"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714901"/>
    <dbReference type="InParanoid" id="A0A194XNQ9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="383" mass="43466" checksum="BE3B859E16503D75" modified="2016-10-05" version="1">MDSSQSIESMAIIARENKPLAHRKKSNVELIGERLGLRLPNYAKDFVHFVNTIGYKLFIVDLQQLNGDTVMRSKAQMAWHRLVHQKYRFWHPQNMTSAEKVRIRSQALNQISGSAAWRKADIEEYWRGKMEVLGLKWNTKNSSTKVSESSLDNKLIPKLQSSDGHVPEAQVLARNEDIGGGMSSKTDMSKEEAKCMDEKQLLQEQIEENAIIDKDWEQEKDEGLADTEEPVLQEDEDLTTPSTSAGITTLKSVTDESQLHEIPAKAPTIPPNFSANFRNPNSNHRTIYEDFDDSDSDSDEEDDRFKRAIDLPPPIPSIEEVEDVPVQKEEEVVDTLQSSPSIGNVEDIPQKKEEEEGAETRQPSPSPFYDNGDDLPDYEDHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP52</accession>
    <name>A0A194XP52_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_391405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076380.1">
        <property type="nucleotide sequence ID" value="XM_018207194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP52"/>
    <dbReference type="STRING" id="149040.A0A194XP52"/>
    <dbReference type="GeneID" id="28816920"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_391405"/>
    <dbReference type="InParanoid" id="A0A194XP52"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="559"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="703"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="107860" checksum="73C8156B991BD65D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ85</accession>
    <name>A0A194XQ85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_574784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076676.1">
        <property type="nucleotide sequence ID" value="XM_018208760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ85"/>
    <dbReference type="GeneID" id="28818486"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574784"/>
    <dbReference type="InParanoid" id="A0A194XQ85"/>
    <dbReference type="OrthoDB" id="4158609at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="86" mass="9110" checksum="371CAB0E508715A7" modified="2016-10-05" version="1">MNSARATAVNGGSGVESTPANNVGGDRRGSASSGMFSGLMSQKRNSTDAAAAARRESFHEMKPASGFIGKMWHKYVHDYEISIGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQC5</accession>
    <name>A0A194XQC5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_680403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076614.1">
        <property type="nucleotide sequence ID" value="XM_018214073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQC5"/>
    <dbReference type="GeneID" id="28823799"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680403"/>
    <dbReference type="InParanoid" id="A0A194XQC5"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="67"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="463" mass="51882" checksum="0797E2CA533B41BE" modified="2016-10-05" version="1">MAARLLESKSHLVPGKLKVSELFFEVPKDHLKPAGGTIQLFARSITRHEKPVTVLSEEEQLKTQQKPWFVYLQGGPGFSCAPPQNHPLTNTVLDKGYQMLYLDQRGTGLSNPITSATLAEQGDVHRQADYLKLFRADSIVKDCEAIRKTLTKDYPAELKKWSLFGQSFGGFCILTYLSKYPHGLREAFATGGLAPIGKSPEEVYKATYRKVVERNKAYYQKYPEDVDAVHGLAYHIRGKAGLPLPSGGVLTVRGFLTLGRNFGMHGGLDIVHNLVLRMKSDLAQFKFVTRPTLSALESALSFDDNVLYAVLHEAIYCENEASNWAAEHVGKSLKEFSWLAGSPQSALAVREAPLFFSGEMIYPFMFDIFPELEKLAPVADVLAKYNGWPELYDQWQLARNEVPLYAATFVDDMYVDFGLAQDTAKLVKNCKQFITNGMYHDAVKSKTDDVMKQLFALRDDSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR43</accession>
    <name>A0A194XR43_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_693957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077013.1">
        <property type="nucleotide sequence ID" value="XM_018216669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR43"/>
    <dbReference type="STRING" id="149040.A0A194XR43"/>
    <dbReference type="GeneID" id="28826395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693957"/>
    <dbReference type="InParanoid" id="A0A194XR43"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="569" mass="62755" checksum="56AF4631C16EA5F3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRH8</accession>
    <name>A0A194XRH8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_680975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077250.1">
        <property type="nucleotide sequence ID" value="XM_018214181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRH8"/>
    <dbReference type="GeneID" id="28823907"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680975"/>
    <dbReference type="InParanoid" id="A0A194XRH8"/>
    <dbReference type="OrthoDB" id="3507552at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="25826" checksum="39B57F137619A652" modified="2016-10-05" version="1">MDSPQHDTEIAMASQQEKEADPKMPFDYSQDSFWESTAFYQQSLATTPIDSGFFEQATLGLSINTSSPHYARGLTNEPSGISYSDWGGSISGDMLSGGEFSPGPRSTKANTFPEPNTRNTTGPRRPSAEAIARRRKQNRVSQAAWRARNKELVEELRQEIAEYSEYNKTMKETMRSLLKTTESLKGVIEHALALPEPKTSQDDGKQSTSEGQLLSPPESSAEGTTFDLDAPHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRL1</accession>
    <name>A0A194XRL1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_680802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077044.1">
        <property type="nucleotide sequence ID" value="XM_018214141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRL1"/>
    <dbReference type="GeneID" id="28823867"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680802"/>
    <dbReference type="InParanoid" id="A0A194XRL1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="85"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="505" mass="56935" checksum="77F422958E3CA8DE" modified="2016-10-05" version="1">MSILARARSRPTQPFQIPQRLFSSCASFSRAWLPKYTQKAGTSPHYPSLRLTVHRSSTWLPPQVRRQVSHRSHIEAMASAPDETYLIVGAGIFGASTALSLIRKYPAANVRIIDREPFPCQLAASWDWNKIIRAEYNDIFYMKLALEAKDHWENDPMYSPFYHVANGVWIQDTNMADVISDNYAELGLPDLVKRYTVEEGKKIYDGLFDQAEYEGIDQVLVSTGTGWAEATKALTKVLQEATEAGLRHVNGNVISLVFNDAGDCIGVRTASEETLTASKTILCTGAATAKLLADSAPYRKELHAGGRFIAAAMCTALMTPEAEACAHFKDVPIVLHERLHYPGRGGFIPPTPDGNFKWWADITFSNLTKHESGEDISSPPTGPYQGQWDVPESFHDEMITGRDVIFGEKAKHFGFDKYRFCWDAISRDDNFFIGPHPASKNLYLATVGSFHSWKFLPIIGSYIVKMLEGTLEDEYTQRWAWDREIEREGAHGYWPKRDWKDLIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRW2</accession>
    <name>A0A194XRW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfpI endopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_607065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076817.1">
        <property type="nucleotide sequence ID" value="XM_018210441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRW2"/>
    <dbReference type="STRING" id="149040.A0A194XRW2"/>
    <dbReference type="GeneID" id="28820167"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_607065"/>
    <dbReference type="InParanoid" id="A0A194XRW2"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="63"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="250" mass="27254" checksum="93C80EAB3368E0AB" modified="2016-10-05" version="1" fragment="single">MTAPKHLQIGVFFPKSVQLLDLSPIDLLAMMSPEYLCACQLPEPLIALGIPSTIHYISVPENGGHVELTASAILKVSKTIDDPEVQAGKLDIILVPGPDPASIFEEPALEFLRSHAYWKSAEGKAVDILSVCTGAILLGQSGILKGKKASGPRALVPKMRKTFPEVDWNDNKRWVHDGNIWSSGGITNGQEMVAFYMREKFPGPATEAAIDMAGVGDKGVDYTKGKTSTTLWWLWQILKAVMIGRSKQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTT3</accession>
    <name>A0A194XTT3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_574468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077804.1">
        <property type="nucleotide sequence ID" value="XM_018208745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTT3"/>
    <dbReference type="STRING" id="149040.A0A194XTT3"/>
    <dbReference type="GeneID" id="28818471"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574468"/>
    <dbReference type="InParanoid" id="A0A194XTT3"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="422" mass="47783" checksum="2DAE5A8CC6A7B0DC" modified="2016-10-05" version="1">MAAEIPSSKDPIPTYRIDLSLPPSERYVQLGKEFAPKMQKITPLFDEVLRPAFPRRWMRRWIAWLAWLFLRRVYSAEETAEIKGLSKAAGVDMYFLVALNVLLDSMLGCTSGAVMTSPKGSKRGKVGEEDKRMMHFRTLDWGMDPLRSVLVVLEFVRSKSEEPEKVIGRSITYAGFVGILTGVKQELSISLNFRPNHECSTFKLRLYQLLVLFGFRPSISHIIRSTIFPPVKTAAVPLEELAVTMSKKQTAPCYLILCDGTSSTVLEKDLLNAKIRTSDEFIVHTNNDTTPALEPAKPLHDADGHPAVLNILDEMGLDAFIKDSKERSACVQKKWNALKGRQRRKQQAQLVEEKDMVSLYVREETLVGWVRKYPTMNGQSHFGCVMDPKKGDIRWLERGACWLSEESLTMAEDDQDVVIVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUL4</accession>
    <name>A0A194XUL4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="5">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_633625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="5"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078258.1">
        <property type="nucleotide sequence ID" value="XM_018211349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUL4"/>
    <dbReference type="GeneID" id="28821075"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633625"/>
    <dbReference type="InParanoid" id="A0A194XUL4"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268677" description="tripeptidyl-peptidase II" evidence="13">
        <location>
            <begin position="19"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="14">
        <location>
            <begin position="230"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ23903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="656" mass="70784" checksum="5E0DE3A76E1B7CCB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVH7</accession>
    <name>A0A194XVH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_634194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078588.1">
        <property type="nucleotide sequence ID" value="XM_018211382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVH7"/>
    <dbReference type="GeneID" id="28821108"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634194"/>
    <dbReference type="InParanoid" id="A0A194XVH7"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="29034" checksum="0DAC5522038BF9AE" modified="2016-10-05" version="1">MSTSKPSILFIPGSFALPEFYDVVLDPIKAQGYEIRALHLLTVGLTTGPREGAPPTMYDDAAFIAKEVEKLVDQEKDIILIGHSYGGIPLSQSTKGLGIEERKAQGKKGGIVKLAYMTCLVPDIGQSAMAMLTDVKEEHRVQFRLDERGWFHQNDIPRAASISFSDIPQEEGEAWIRRMPAHSAVSFTNELTYAGYKDIPVSYLICEEDLVIPLRMQRDEIELIEKVSGKKVDVTSIKTGHIPPASQPQKVIDWILSVIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVS9</accession>
    <name>A0A194XVS9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_703444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078683.1">
        <property type="nucleotide sequence ID" value="XM_018217322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVS9"/>
    <dbReference type="STRING" id="149040.A0A194XVS9"/>
    <dbReference type="GeneID" id="28827048"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703444"/>
    <dbReference type="InParanoid" id="A0A194XVS9"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ24328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="590" mass="65539" checksum="FFC443438E944047" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVW8</accession>
    <name>A0A194XVW8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_727199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078519.1">
        <property type="nucleotide sequence ID" value="XM_018219127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVW8"/>
    <dbReference type="GeneID" id="28828853"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727199"/>
    <dbReference type="InParanoid" id="A0A194XVW8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16834" checksum="EC0951B5640F7D77" modified="2016-10-05" version="1">MAAAVFFGPVPPPSRLPDPPWFTRQCRPHHDATDTTLLRCLLMNHLQENPQSTIAHNIFNVQSRDEHLIYEHRIYAGATPIQEAILLSNRLESLHHIGIRNHVNKNSNVEGQKARFFTVSTALHAVIIRKGSASLWLVMIPIAVNGLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWJ7</accession>
    <name>A0A194XWJ7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_679634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078861.1">
        <property type="nucleotide sequence ID" value="XM_018213916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWJ7"/>
    <dbReference type="FunCoup" id="A0A194XWJ7">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWJ7"/>
    <dbReference type="GeneID" id="28823642"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679634"/>
    <dbReference type="InParanoid" id="A0A194XWJ7"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268762" description="glucan 1,3-beta-glucosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="81"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ24506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="47220" checksum="90FCA26126A4EC8B" modified="2016-10-05" version="1">MVFIKALTIVAACLSLADATPLNKKRQLAFDYNDDKVRGVNLGGWFVLEPWITPSIFDQWANGGGVVDEYTYTQALGPTEAFNRLNQHWATWITQDDFNEIASYGLNHVRIPIGYWAVNPQPGDPYVQGQLTYLDQAIGWARSAGLKVMIDLHGAPGSQNGFDNSGRYGAIDWQSGDNVAQTLTAIQDLANRYASQTDVVTAIELLNEPGNWALDMSQVKQFYYNGWGNVRSDNAYTAVVIHDAFLDIESYWNGFMNSASGVNDVILDTHIYQIFSDGEVAMKPCEHVQTACAAGPNLAGTDKWTIVGEWTGAQTDCAKWLNGLGKGARYDGTLSGSTGYYGDCQSKYEGTVDGMLDVDKVNLAYYVEAQLDAYEQHSGWIFWAWKTESAPEWHFQNLTRAGLIPQPITSRKYANQCQTSSCLIPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1P1</accession>
    <name>A0A132B1P1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060647.1">
        <property type="nucleotide sequence ID" value="XM_018216559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1P1"/>
    <dbReference type="STRING" id="149040.A0A132B1P1"/>
    <dbReference type="GeneID" id="28826285"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692545"/>
    <dbReference type="InParanoid" id="A0A132B1P1"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="106" mass="11940" checksum="F7F0C7715479CA2A" modified="2016-05-11" version="1">MFNRALQGYEHALGPKLLPSYLLALDTKFAFGDLFSQTGRKDLANVMYSRALAGYITVQGPSSKRCKQLKDRLQALQIAFAESKVGQDEFTEPRAAKSRPFKQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B268</accession>
    <name>A0A132B268_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_603160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060835.1">
        <property type="nucleotide sequence ID" value="XM_018210289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B268"/>
    <dbReference type="STRING" id="149040.A0A132B268"/>
    <dbReference type="GeneID" id="28820015"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603160"/>
    <dbReference type="InParanoid" id="A0A132B268"/>
    <dbReference type="OrthoDB" id="3549121at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="11733" checksum="11AD868AD87667F4" modified="2016-05-11" version="1" fragment="single">QPGGQDSQIITSDGSARLETNYILQTYDQPPAHIVIKTHGWRTGPPEVLARLADPKLADNVDPHSYKMRLFIDMETGDERYRDKINCGMWIGSGMRKGAEVIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2M4</accession>
    <name>A0A132B2M4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_726321</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060997.1">
        <property type="nucleotide sequence ID" value="XM_018219045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2M4"/>
    <dbReference type="GeneID" id="28828771"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726321"/>
    <dbReference type="InParanoid" id="A0A132B2M4"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287793" description="chitinase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="424"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ06642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="52909" checksum="619419E7AD308A42" modified="2016-05-11" version="1">MQYLSLLLGAAALVAPVFAQTWTTCNPMNVTCPNDPSLGISHNFVFNSSDTVTNSFNITAGSLVYGTNGTEFTINKKGDSPTIQSQFYIFFGSVSVVMKAASGQGIISSIVLESDDLDEVDWEFLGGNGTHAETNYFGKGNTTSFDRAIYYPTGTDNRDNFHNYTVHWTSDQLQWYIDSQLVRVLPYASANGGYNYPQTPMTVRMGIWAGGDSGNSNGTIEWAGGLTDYSQGPYTMTVQSALISDFSTGSAYQWTDKTGDWQSIKAIAGNSTAAETILKADTPTLSMAQKWQALPQTTKIAVYAGSGGAAAILIAALTFTCIRQRRAGRKERDDYNAKVEKEREEAYRDQMELREKGLGGWDQGAYAKQGDDALGGWGGAHVPPGYAADAPALPKMPSNVMVNEVPSRMNSPAFERSMSPVSRHQTPALVSPGPESPRTWNGGNQGGMIHNAGNAYSGGYGGSSNIPRSPSFPLGKSVPPQRGFSSGGYQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2N4</accession>
    <name>A0A132B2N4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_632761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060946.1">
        <property type="nucleotide sequence ID" value="XM_018211316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2N4"/>
    <dbReference type="STRING" id="149040.A0A132B2N4"/>
    <dbReference type="GeneID" id="28821042"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632761"/>
    <dbReference type="InParanoid" id="A0A132B2N4"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF65">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="198"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="302" mass="32156" checksum="B20D036047000B84" modified="2016-05-11" version="1">MATNEESPRTGQTLAIIGCGTMASAILSGVLNACAASQAQGDEPRISRFIATVQSEGSAAALRSRFQDRIEVIRGDNVTAMKEADLVLLAFKPYMVDKVLRNEGVYEALLGKLVISVLVGSPVQKLEDAIRLCQPFGKGTITNKAGALHIKRAMMNIAVEFGAGMTVIETTEDMPPSYNELTDWIFLQCGKIQSVAPELFDIGGVMAGASGALLSVAFDGMLDGAVSQGLKRADAKKILTQALFSLATLLENGEHPAVLREKFSSPKGTTIDGLLSLEEDRARYAFSKAVIASSKRSQEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B384</accession>
    <name>A0A132B384_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxy-cis,cis-muconate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ06499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:6-phosphogluconolactonase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="358" mass="40512" checksum="C02A22BC0BC75B70" modified="2016-05-11" version="1">MKHHLMVGTWTPPGAIFTFEFDDETLELNMIKRTEIPKDEPISWMTFDHAKENIYGAAMKKWSSFAVKSPIEIVHDASHPMEHLPEASKSDTNTRAIFVLAAKKPPFNVYGNPFYDHAGFGNVFSVNQEGGLEKCVQNYQYEPKTGIHGMVFDPTETYLYSADLRANKIWTHKKDEQGQLTLVGSVEAPDPGDHPRWVALNQSYLYVLMEAGNRIGVYVIDPQTHCPVFTHITYPLIPPGIPNPKTMYRADVVTLTHSKKYLFATSRANKHNLTGYISAFKLGPAGNIERQICMNPTPNSGGHSNAVSPCDWSDEWIALTDDQDGWLEIYRWKDEFLARVAHCDVKEPGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B423</accession>
    <name>A0A132B423_MOLSC</name>
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        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_790076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061338.1">
        <property type="nucleotide sequence ID" value="XM_018223330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B423"/>
    <dbReference type="FunCoup" id="A0A132B423">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B423"/>
    <dbReference type="GeneID" id="28833056"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790076"/>
    <dbReference type="InParanoid" id="A0A132B423"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="824" mass="91326" checksum="ECC132E341679406" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4E7</accession>
    <name>A0A132B4E7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_790405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223365.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_790405"/>
    <dbReference type="InParanoid" id="A0A132B4E7"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="599" mass="67707" checksum="C7D31291E7FD44D5" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4S4</accession>
    <name>A0A132B4S4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_366224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061761.1">
        <property type="nucleotide sequence ID" value="XM_018207026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4S4"/>
    <dbReference type="STRING" id="149040.A0A132B4S4"/>
    <dbReference type="GeneID" id="28816752"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_366224"/>
    <dbReference type="InParanoid" id="A0A132B4S4"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="5">
        <location>
            <begin position="118"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="440" mass="49343" checksum="6EEC77DACCC1F113" modified="2016-05-11" version="1">MDAQNKSLVNIFFTGNLCVKFVRLQWVDYSGVLRTRIITKGRCQQLASGSDYYQLAQNCMVIPLSTAPRCWPDGIEEWNLCPDWTSLRVCGFAPTHASVMCATANRNLSATDHFARCPRKLLSKVLDAFDKQDKSKLLMGFEIEFVLLDETFNLAKSMDQTVGYSMTAGLRTEKLVVMEEIVAALEVSGIEVYHFHTEIVDQFEVALSPMPPMQAIDALMMAQETIRTIFLRYGLRATMAPKPVFNGPQSGCHVHVSLNPGTKDSSASFLAGVLCKLKPLCTFGLANYDSYYRVSGDCAGEWVAWGTHNKDLPVRQVNPNRWEFRFLDVTANMYLSIAAILVAGIAGMKRQQPLTISDVQLVPSALSHAEAGRQLQAYGVTESMPSKLEQALDAAKHDEELQGWVGTELFEQYVKVKDKEVEYFSKMTDEDRKLVFVRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B567</accession>
    <name>A0A132B567_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_398396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061172.1">
        <property type="nucleotide sequence ID" value="XM_018207244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B567"/>
    <dbReference type="GeneID" id="28816970"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_398396"/>
    <dbReference type="InParanoid" id="A0A132B567"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="445" mass="48731" checksum="5DAF759246E35FD3" modified="2016-05-11" version="1">MLANKWIADLLAYLDRSNIGNAKIAGMQEALKLDSGSYAWLLTIFYISYIVFEPLALMWKIIPPHIWGCFCVLGWAVCGTLQAATFNWSGMMAVRFFLGAFEASFAPGITYLLSFFYLRNELGLRCGLYLSAAPLATCFAGALAYGITSGHPHGISSWRLLFLVEGLPSLVAGVATWFLMPDSAETAKFLTEEEKAVAKARSVRQVGKDQNVRIHGINGRDVGHAILDFKPWINALMYFSCNVSFASLPVFLPTILAAMGFSNINAQGLSAPPYFLAFLVVLVSCWFADKTAQRGFTILFLSLLGAAGYIMLAVSSSTGVRYAGVFLAAAGIFPCIGNILPWVMNNQGSDTRRGTGIAIINVVGQCGPLLGTRLYPSSEGPYYRKGMWVCAAFMLFNGFLAMLLRALLVWENKKLDAKYSPVIHQKGGEPEEGEENEGPRFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5R4</accession>
    <name>A0A132B5R4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062110.1">
        <property type="nucleotide sequence ID" value="XM_018220833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5R4"/>
    <dbReference type="GeneID" id="28830559"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742528"/>
    <dbReference type="InParanoid" id="A0A132B5R4"/>
    <dbReference type="OrthoDB" id="4874932at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287882" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="12421" checksum="89F250550D57B8B9" modified="2016-05-11" version="1">MRLFVALSAVLPLISAEVIVGQLNFYYDTNCKSYAGSVYPSPTEASSGVLGNVRGGPAGSKSLLWVSGGLGPECQGPWFFACKNKECSAWDGVEQGECKSFENGVWGAYQELCPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B635</accession>
    <name>A0A132B635_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_353890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062231.1">
        <property type="nucleotide sequence ID" value="XM_018206951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B635"/>
    <dbReference type="GeneID" id="28816677"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_353890"/>
    <dbReference type="InParanoid" id="A0A132B635"/>
    <dbReference type="OrthoDB" id="5211607at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287918" evidence="1">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="19599" checksum="A2256E15020270C8" modified="2016-05-11" version="1">MKYPLIRVSILGLLASCGASISVSAPTVNGDTTVTEPIILNSAGVQKGFVAPKPGSSVPNSTSVKLLPRSNILRKRDDYFCTGDAPDVDDCNEVINTALDDNETITIPDNLCFEISYQTCVGYVCSTPCGGYTFSTTWFGNTLSDLLSLCVDDGQGGEIYTTSDVIYEVGFVTDGEGFPQYEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Q6</accession>
    <name>A0A132B6Q6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_691327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062376.1">
        <property type="nucleotide sequence ID" value="XM_018216285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Q6"/>
    <dbReference type="FunCoup" id="A0A132B6Q6">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6Q6"/>
    <dbReference type="GeneID" id="28826011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691327"/>
    <dbReference type="InParanoid" id="A0A132B6Q6"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="240"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="51398" checksum="55743C42CE5DB875" modified="2016-05-11" version="1">MSTLEDLDDLEREQKEDKKDDGDKEKKPNQNGDAEMKDAEPEEKEEDPIDEEIYSLSTQDILTRRRLLENDSRIMKSEFQRLSHEKAAMGEKIKDNLDKIENNRQLPYLVGNVVELLDLDPTAESQEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDPEKLKPGDLIGVNKDSYLVLDTLPAEYDSRVKAMEVDEKPTEKYTDVGGLDKQIEELVEAIVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLLARACAAQTDATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPAIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAQILKIHSRKMTVDDAVNWPELARSTDEFGGAQLKAVCVEAGMIALRMGKNKISHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6S1</accession>
    <name>A0A132B6S1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_742470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062054.1">
        <property type="nucleotide sequence ID" value="XM_018220826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6S1"/>
    <dbReference type="GeneID" id="28830552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742470"/>
    <dbReference type="InParanoid" id="A0A132B6S1"/>
    <dbReference type="OrthoDB" id="4873887at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24084" checksum="CF4FC6A2739A6B21" modified="2016-05-11" version="1">MASPYPVVEVAIINIKGQNVEDETTKEGKTWHEVFKKLISVPGFTRVGWGRSVRDHDTVIFGVDWESYQHHQDFMEAKGTFTSLLMDLLKHGAAFYAAFSAAVFLWGVDEEKFPSLVKPWITANEKSDSCLGYFWGEVKSPAKVDTSKNLELGKCVIMLSGWKSKETHDYDCGLSIVVDAYKALQAAVKKSDTYPIEFHCVEKSGMEMSWRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B702</accession>
    <name>A0A132B702_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_600140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062543.1">
        <property type="nucleotide sequence ID" value="XM_018210140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B702"/>
    <dbReference type="STRING" id="149040.A0A132B702"/>
    <dbReference type="GeneID" id="28819866"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600140"/>
    <dbReference type="InParanoid" id="A0A132B702"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="33649" checksum="8853CD01ACD33647" modified="2016-05-11" version="1">MSKLLVIFGATGQQGGSLIQTILSDPTLSKTYTLRAVTRDPAQPTAQSLSSRGVSLIKGDPDDTSSLGPIMKDAHTVFAVTTTTYDAECYARELRQGKAIADAAVAAGVQYLIFSSLPHVSTLAGGKYKGVQSFDAKAEVEMYVRGLPIKSAFFQPGSFMSNFQGGMKPNPVGDGTWAWFNVVTPQTRLPLIDTAGDTGKYVCAILAEPEKFEGKILCASTEVLSMEEICETIGKASGKTVVYKQLPENVFRGFMKNEVQSDNITQMMLYIQDFGYYGKDTVGKVAETAELARGKLTTLEEYLKKNPLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B744</accession>
    <name>A0A132B744_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_691067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018216228.1"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
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    </dbReference>
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        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="519" mass="56824" checksum="422DB32A55AE6F99" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7K0</accession>
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        <recommendedName>
            <fullName evidence="9">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_711791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ07959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="540" mass="58715" checksum="46A9036025CB1A49" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="33"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36296" checksum="8200278AC6AD4631" modified="2016-05-11" version="1">MGREEVMPHDERYTAAEELWEKSWEDGAQVWQEEPEMAYDPSKIHKINYEGKYHKMNAFHQTHPSPQRTPLLFQAGSFKAGIQFGGKHAEAIFCANPTIESTKKYTAAVRAKAVEEGRDPPSIKFFLGIMPILGRTAEEAEMKFEAAKKNVSVNGGLARFCGFTNVDLSGYAIDEEFNFEGKHHENSIQGVIDNIKLIGTEKVFTPRVVAEMFALGGSGPRPVGTPEMVADFFEKWWREGDLDGFNLNYVSNPESFEDVVELLIPELQRRGIYWEDYPVPGGAARENLHSNPGQKLLPKEHPGAKVRWDVAREAATKHKAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9B9</accession>
    <name>A0A132B9B9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_628822</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063350.1">
        <property type="nucleotide sequence ID" value="XM_018211188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9B9"/>
    <dbReference type="FunCoup" id="A0A132B9B9">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9B9"/>
    <dbReference type="GeneID" id="28820914"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628822"/>
    <dbReference type="InParanoid" id="A0A132B9B9"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="331"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="483" mass="53015" checksum="B4614E300743B13F" modified="2016-05-11" version="1">MAVLFSLPNEVMLNALCAQFPCRDQQIRSLATLLSVRAAPCRNLVLHGLAATGKSSIAKTVLEYLSKRQTNGYANGSTQHDDDELRYAVIKSAECIGGRHLFEQTISTVSKVIGRSENVGRCENLAQLAVELSKLVENWTASEQDSRQRLVLVFDGIDRQRDAPPTLLPALARLVEIVPNLTTIFIVTSPRPNFLHLPGVPHLEFPAYTKPELLQILALTEPSPVLPQGTKETKDVWTRYSSAIWDSLSKHSGRDILSFRSVCLRLWPRFIRPILDGTLNPSPFSRLMVANRSLFQNDSILVPALVSNPQSTALVPQSQSQSNLQGIAIQLPHISRLLLVASYLASYNPPRTDSTFFMKAALAKRRKKGGGTALSRKPGTAKSRKIARKLLGPQAFVLERMLAIFLAIEEDAGKRKGKAALNGSADVLMAVTTLASLRLLVRMGGPNQDVLDVGTKYKIAIGWEVIRGVARSVGVEVEDYLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9F5</accession>
    <name>A0A132B9F5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic aminotransferase Aro8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_318386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063393.1">
        <property type="nucleotide sequence ID" value="XM_018206690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9F5"/>
    <dbReference type="STRING" id="149040.A0A132B9F5"/>
    <dbReference type="GeneID" id="28816416"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_318386"/>
    <dbReference type="InParanoid" id="A0A132B9F5"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="158"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="505" mass="57072" checksum="80132050515CD144" modified="2016-05-11" version="1">MARLTMDDVESLRAESEPMLMDIATYSLSDSYKSQHCNKKPQSKSMVDHFSIEASNFRGSALKRTAKQHFKSRLIPLGIGRPIDDFYPWESIALKESFTLPQSSHTIGLNPNVNTIAKRQGLFNLSTGLNYSHSVGQQPLLRFITEHVEIIHNPPYRDWSVCLTCGSTSALEIALRMFCNRGNAVLTEEYTYPGFISSTQLLGVQTVGIRMDDNGLIPEELARTLRTWDDSTGSRPRVLYTIPSGQNPTGITQSLERKKAIYQVAEEYDLIIIEDDPYYFLQATHQTMPNTNAIESYISHLPPTFLPLDHSSRVIRLDSTSKILASGLRAGWVTSSNEIIEKFISYQEVGPLAMSGPTQLMLWNLLDAKWGHRGFMAWLEHLSRQYRARLDIVLEACEKYLPKDVCSWKPPDCGMFLWIQVAVEKHSEFRESGFKVADVEERIWSRACENGVQVTKGSLFNAAASRPSRVSFRLTYAAADEDELDKGVKLFANAVREEVGLERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA75</accession>
    <name>A0A132BA75_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063661.1">
        <property type="nucleotide sequence ID" value="XM_018216081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA75"/>
    <dbReference type="STRING" id="149040.A0A132BA75"/>
    <dbReference type="GeneID" id="28825807"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690351"/>
    <dbReference type="InParanoid" id="A0A132BA75"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="607" mass="64999" checksum="BB748AE0FC79C0EC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAS1</accession>
    <name>A0A132BAS1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_741193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063841.1">
        <property type="nucleotide sequence ID" value="XM_018220677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAS1"/>
    <dbReference type="GeneID" id="28830403"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741193"/>
    <dbReference type="InParanoid" id="A0A132BAS1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="180" mass="20762" checksum="0A5AF07425D67C02" modified="2016-05-11" version="1">MEQHHIKTEPYIKSETRDELHSVNPYIKSETENEIHSVNAYIKSEHPDTGSAYMKSEDGKVKLEEFYASQPLDQPPAISKGRKQRNKSNNDRAATKKEARRRRMQRRMAASIVKSGIGKGKRTNIKSKAPETMEAYKRLGQDPDDAEALETFLKYNPWFVEQRRTVYQPGVGMVRPGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCF7</accession>
    <name>A0A132BCF7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_596928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064450.1">
        <property type="nucleotide sequence ID" value="XM_018209952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCF7"/>
    <dbReference type="STRING" id="149040.A0A132BCF7"/>
    <dbReference type="GeneID" id="28819678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596928"/>
    <dbReference type="InParanoid" id="A0A132BCF7"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="485" mass="51426" checksum="6022924BB728E3B5" modified="2016-05-11" version="1">MLLRHLISTPSSRFIMATSKDKTVIVVGSGLAGLTAASTLVSHGICVHLLERAAKPGGNSMKASSGINGAPTKYQPGPPFSDTFFHADTIRSAGSVFQTMKKERESLISTLTNQSAEAIEWLVEENGIDLSVVAQLGGHSFPRTHRGAGKTPPGASMVSTLLTSLKSSPLFHLDTSCTVTKVLKPSSVVSGVEYICTGEKTPKKALGPVISATGGFGGDANGMLAQYRPDLAGFPSTNDPRPGSQPLLTVVGAQLLDMEQIQIHPTSFIDPANPLNPVKFLAAELLRGEGGVLLFQGKRFVDEMQTRKVVTDAITRLPAQTAEGGPRQWDVQLVLDEGVYENASSHIDFYLWKGLMRKSTIADLGTAAFSTLRDYAAAAAGHASDSFNRESFGHWKLHAVKEDSVVYVSTVTPAVHFTMGGVLISEKGEVVDESGKPIRGLWAAGEVTGGVHGENRLGGSSLLECVVFGRVVGEQAAKFVKGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCM0</accession>
    <name>A0A132BCM0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064476.1">
        <property type="nucleotide sequence ID" value="XM_018220599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCM0"/>
    <dbReference type="STRING" id="149040.A0A132BCM0"/>
    <dbReference type="GeneID" id="28830325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740515"/>
    <dbReference type="InParanoid" id="A0A132BCM0"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15351" checksum="2C17C1FFBCCB7115" modified="2016-05-11" version="1">MLETDAPKVDGEAFFITNAKPLPAWTLFRKVWAAVGDRSTEGEVWCVPAWFSVGLGTVLEWLFWLFSFGTRTPPDFRSHTLRWINEERTFSIDFARERLGYQHKDDIDQSSQCIKDGVAWALMQNRDFCKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCM8</accession>
    <name>A0A132BCM8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_689967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064501.1">
        <property type="nucleotide sequence ID" value="XM_018216004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCM8"/>
    <dbReference type="FunCoup" id="A0A132BCM8">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCM8"/>
    <dbReference type="GeneID" id="28825730"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689967"/>
    <dbReference type="InParanoid" id="A0A132BCM8"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="23908" checksum="4B5EEA325B7E59C8" modified="2016-05-11" version="1">MVIKVHGVAQSTCTQRVLTALIEKNVPYELVKIDFMTGEHKSEAFLKMQPFGKVPALEEDGVFIFESRAIAKYIARKFAGQGTKLMPADDDLIGYALFEQGCSLENAYFDKPASSIAYEKMFKKFRGLGGPDEALVKKYSDDLDGILAVYDGILAKQAYLAGDKVSLADLFHLPYGNVVKQTGGAELFAKHPNVDRWFTALENRESWVKIGQLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDE7</accession>
    <name>A0A132BDE7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064781.1">
        <property type="nucleotide sequence ID" value="XM_018215950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDE7"/>
    <dbReference type="GeneID" id="28825676"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689675"/>
    <dbReference type="InParanoid" id="A0A132BDE7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="10081" checksum="70A2EE56F207B749" modified="2016-05-11" version="1">MSSNNPSAPPSPPPPTQTQPQTPKRTAAPSSPVSLPAGVNLNLLAEYRAQQYRDSLASVQANTTTYTIDFLRIVTTTGATTTTLEIVNIVRRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRP1</accession>
    <name>A0A194WRP1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF2B subunit epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_595486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065020.1">
        <property type="nucleotide sequence ID" value="XM_018209862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRP1"/>
    <dbReference type="FunCoup" id="A0A194WRP1">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRP1"/>
    <dbReference type="GeneID" id="28819588"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595486"/>
    <dbReference type="InParanoid" id="A0A194WRP1"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="W2" evidence="12">
        <location>
            <begin position="548"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="738" mass="81165" checksum="0F8EF01B7A4D91F9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRV0</accession>
    <name>A0A194WRV0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_571560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065065.1">
        <property type="nucleotide sequence ID" value="XM_018208598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRV0"/>
    <dbReference type="GeneID" id="28818324"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571560"/>
    <dbReference type="InParanoid" id="A0A194WRV0"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="283" mass="32767" checksum="CD62D2B63DB97BAD" modified="2016-10-05" version="1" fragment="single">DTTKANIEPYAVLSHTWGHDEVTFQDMMLPNVLSKEGYSKITETCRLALAEDLNYVWIDTCCIDKTSSAELTETINSMFELYKKVAVCYVYLQDLDPQTYLKNGLKSCRWITRGWTLQELLASEKVHFYDRTWRCRGSKVDWAHDISIATGIHHDALLGRPLQAFSIAQRMSWASDRETTRAKDLAYYLLGIFEVHMPLIYGEGKHAFRRLQEEIVKRTNELTIFAWNQSKDCMNCTDPEPDHDGLFAPSPSNFYTSHDIIRSSHFESEFTLTNRGLKLKHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSV1</accession>
    <name>A0A194WSV1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_249194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065052.1">
        <property type="nucleotide sequence ID" value="XM_018206174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSV1"/>
    <dbReference type="GeneID" id="28815900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_249194"/>
    <dbReference type="InParanoid" id="A0A194WSV1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="169" mass="18902" checksum="0AB1BECD53510E2C" modified="2016-10-05" version="1">MSSGCGAPPLKKDSLGEKNLEARHLDLFYDTNHPIFNKSPCYSTSSQTDPSIDQRNESLDPLPPPCCYFLIYRCSGVKDVRAALLDVSRFSWDFLSLPELASAAQHIFSLSVFSPNYMGGNFLSLATKPPHQTKPNSSDQRDHPDLRHGDSPRESNLILQSLPYRCVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUL5</accession>
    <name>A0A194WUL5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_723119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065657.1">
        <property type="nucleotide sequence ID" value="XM_018218792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUL5"/>
    <dbReference type="STRING" id="149040.A0A194WUL5"/>
    <dbReference type="GeneID" id="28828518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723119"/>
    <dbReference type="InParanoid" id="A0A194WUL5"/>
    <dbReference type="OrthoDB" id="4670414at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="32577" checksum="AAEE4CC755A58EA0" modified="2016-10-05" version="1">MPQVTYVTYTRGVDAKHLHLGNLVHDFKDPLNLEPYVEKAYTDLSEPAPAWARSRALDNFALTLGETPEDEEKEEEDEEVEGNKYLVAAAAKSTQLEIDDPEEFFEKITLKSDKAKKWLASHISAAESLQPHAPPQIWMATGLILMTHATWTNLSSKQTFTPGLPAPFDPTGVTAIRRSSVSEHIRPVIGYEEKEDTKHIPGAVIHETGKYPGTRGWAIRWERVDTKVMSAEKWKGGVDNQLMLNIPKMFPKIAIVELQEGTYAQNADKGSEDDDNYWDLFIDLVEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUR6</accession>
    <name>A0A194WUR6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_710399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065712.1">
        <property type="nucleotide sequence ID" value="XM_018217825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUR6"/>
    <dbReference type="GeneID" id="28827551"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710399"/>
    <dbReference type="InParanoid" id="A0A194WUR6"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29793" checksum="5829AF22014FCEA5" modified="2016-10-05" version="1">MRLINTTTLQLEEYFDRKIPPYAILSHRWEEEEVTFQDMIAEGAANSFKITGCCQRAREDGLKYAWIDTCCIDKSSSAELSEAINSMFKWYKNAEVCYAYLSDVLINGFDSTSLSSMFRRSRWFTRGWTLQELLAPHTIIFFDITWTEIGTKLQLRPLIEQITGITHLLNFNRASIAQKMSWAAERVTTRVEDQAYCLMGLFGVNMPPLYGEGDNAFRRLQLEILEVSDDESIFAWKEDLLWDTAGRMQSNLTLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV93</accession>
    <name>A0A194WV93_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_673700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066241.1">
        <property type="nucleotide sequence ID" value="XM_018213379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV93"/>
    <dbReference type="GeneID" id="28823105"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673700"/>
    <dbReference type="InParanoid" id="A0A194WV93"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="238" mass="25799" checksum="BE80FB56766BDC72" modified="2016-10-05" version="1">MWMDGDCLWLSSAGSVVVVWYGSVVVPYACARRWSEVRFVATPVQLASRELVPPERSLASARFVPHWELRRKRQMIGRKGRNTMDSSSSSSRKAQKRGVEQPRGKEGEREGASQKRRREGEGKRRRGQVATSWCCTARLDWTLRPARVILSQPGGGQGGGQGGGQGGGQGGGQGEGQGEAQNAVKSASSAEDARGRDKQLRRFRASQPGQGRVGKGRVCRVGEARRGGFTSSDLSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWZ8</accession>
    <name>A0A194WWZ8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066815.1">
        <property type="nucleotide sequence ID" value="XM_018215648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWZ8"/>
    <dbReference type="GeneID" id="28825374"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688148"/>
    <dbReference type="InParanoid" id="A0A194WWZ8"/>
    <dbReference type="OrthoDB" id="3518533at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7907" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="159" mass="18257" checksum="1476E095B488395D" modified="2016-10-05" version="1">MASQQFFLKTAPFPGEEPSKYTNLYLRHFGSGMDSIVLTPGQPKYIKGHMEGKRIAFTSASHEGRKWGLELRKDGEQHAGWEKVEIVEREGSDGLLFTTGEEGEVLEYEEEELAGEKVWKGWMVCDWAHGYPQLFWVTHKLSGELPPFCHRVQIVREML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX16</accession>
    <name>A0A194WX16_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_786263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066482.1">
        <property type="nucleotide sequence ID" value="XM_018222963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX16"/>
    <dbReference type="FunCoup" id="A0A194WX16">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WX16"/>
    <dbReference type="GeneID" id="28832689"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786263"/>
    <dbReference type="InParanoid" id="A0A194WX16"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="303" mass="33266" checksum="E2E449507358E619" modified="2016-10-05" version="1">MSVLLPTHPSSFSEFAIHHAHHNPVSPHTPRMSNRKRKADEDGLDESMSISPQASPAFAPRTIARPAKKARANEVTGRPLTLPRLLETLDADSLRSVLQTICERRPEIGSEVVASAPRPSVMAAVDVLSQYQDKLREAFPFGGNAGSDYAYNRVKQQLTDLIDALTDFTPHYLPPNETSTNTSLSYLDSATKVIHDLPEWNSQSHKHHKDNAYDEISRAWALVVTEASKRGGGFHLHSGEWDQRLQKHNEQSGGRMQTAVNALGSNLGWMGGMGSGDNSIRAQLFNNTYGTGGGNLPVRVGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXG0</accession>
    <name>A0A194WXG0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_592621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067023.1">
        <property type="nucleotide sequence ID" value="XM_018209708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXG0"/>
    <dbReference type="GeneID" id="28819434"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592621"/>
    <dbReference type="InParanoid" id="A0A194WXG0"/>
    <dbReference type="OrthoDB" id="4661107at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="57" mass="5730" checksum="63C897BD87846E00" modified="2016-10-05" version="1">MCTSSTSVLVNRNGPGSAAASTISSIVKPESGGAGKTKCIECDGYECCCIPIPCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXQ2</accession>
    <name>A0A194WXQ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_536641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066727.1">
        <property type="nucleotide sequence ID" value="XM_018208108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXQ2"/>
    <dbReference type="FunCoup" id="A0A194WXQ2">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="GeneID" id="28817834"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_536641"/>
    <dbReference type="InParanoid" id="A0A194WXQ2"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="33210" checksum="E69FA8897AD99A2A" modified="2016-10-05" version="1" fragment="single">LELLHFFTTTTSLTLSNLPEQQRLWQQVVPKIAFSHAFLLRSILALSAIHLGRLYVERRSTLCPVATLHHTAGVILFRTAMPSITPENCDACFAFSTLLVIYAWSSSCQTGDLFFVDSSKTDGGTVEWVSLLRGCHNLLQLACTWLKNGPLRSLLLLQIEESWSAVPDPDSNSKFRSLAALWDKSRTHLKAEEADALDEALTFLIEVHAFLSLRDQAIDEVGTTLSWPIRVRDSYIAMVSQQKPEALVVLAHYCLLLNKIDHFWFMAGMSRCLLQTVHRTLGAEWESWIAWPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY13</accession>
    <name>A0A194WY13_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_785902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066934.1">
        <property type="nucleotide sequence ID" value="XM_018222932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY13"/>
    <dbReference type="FunCoup" id="A0A194WY13">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="28832658"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785902"/>
    <dbReference type="InParanoid" id="A0A194WY13"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="32920" checksum="62D6A36C3484E6D4" modified="2016-10-05" version="1">MPISDFKYYHYDPTLVGAIIFIVLFIATTSLHSYQLLRTRIWFMIPFVVGGLFEWIGYVGRAVSSQQSPNWTLGPYIVQVLLLLVAPALFAASIYMELGRIILLVDGEAHSWIKKRWLTKIFVAGDILSFLLQAGGGGIQSSGKASSVTTGSHIITGGLVIQLLFFGFFIIVAVHFDRAIHKNPTPRSQSPHVPWRKHLIALYVASLLIMIRSIFRVVEYVQGFDGYILSHEVFLYLFDSVLMFAVMVIFNVVHPSEVNALMRGGNAVKNGWQMERIEGHFERVARGDSGDTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYA9</accession>
    <name>A0A194WYA9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_737851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067306.1">
        <property type="nucleotide sequence ID" value="XM_018220302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYA9"/>
    <dbReference type="FunCoup" id="A0A194WYA9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="28830028"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737851"/>
    <dbReference type="InParanoid" id="A0A194WYA9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="27"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="577" mass="63296" checksum="3B625F45DFF61159" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYG7</accession>
    <name>A0A194WYG7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_687896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067361.1">
        <property type="nucleotide sequence ID" value="XM_018215601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYG7"/>
    <dbReference type="STRING" id="149040.A0A194WYG7"/>
    <dbReference type="GeneID" id="28825327"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687896"/>
    <dbReference type="InParanoid" id="A0A194WYG7"/>
    <dbReference type="OrthoDB" id="255837at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26526" checksum="E2A420D467531DFA" modified="2016-10-05" version="1">MPPRTPRRTRQRHHNSSESHAQPAPVQASDYDSEAFYNEPAPERTRDQINESVIRRYVPSLNHIVAIAPNAVIYTFAADSGNWDKANIEGSMFVCQLAPSPVTGGTRHCIIVLNRKGMENLIIESGEIEDVEIKDDILILRFQSHEEIKTMGVYIHGDQFNSRDYICQLVRAHWETAMEERTEVGSEEYDEEVLQSIEAPEENRPMGRRISLSELFGRREQTEDEEYYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZI4</accession>
    <name>A0A194WZI4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_721384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067710.1">
        <property type="nucleotide sequence ID" value="XM_018218642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZI4"/>
    <dbReference type="GeneID" id="28828368"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721384"/>
    <dbReference type="InParanoid" id="A0A194WZI4"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="60745" checksum="12343B8B8723FAAA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZW7</accession>
    <name>A0A194WZW7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_158891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067845.1">
        <property type="nucleotide sequence ID" value="XM_018205480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZW7"/>
    <dbReference type="GeneID" id="28815206"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_158891"/>
    <dbReference type="InParanoid" id="A0A194WZW7"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="694" mass="78350" checksum="FA874FF876586B6C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X009</accession>
    <name>A0A194X009_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_687589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067880.1">
        <property type="nucleotide sequence ID" value="XM_018215531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X009"/>
    <dbReference type="GeneID" id="28825257"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687589"/>
    <dbReference type="InParanoid" id="A0A194X009"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="107" mass="11976" checksum="778594B3D0FC0923" modified="2016-10-05" version="1">MSRSASSSLLLAINSTSWSLEMWVHHMGTTRSLDRYDSKAITTAVSGPATFFDPGKPMKVTPEDSVVFVSVDSEDNELSYGDFDNCSTILRRLSRSPFQPHLRSCKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X099</accession>
    <name>A0A194X099_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_687640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067975.1">
        <property type="nucleotide sequence ID" value="XM_018215547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X099"/>
    <dbReference type="GeneID" id="28825273"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687640"/>
    <dbReference type="InParanoid" id="A0A194X099"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267668" evidence="8">
        <location>
            <begin position="38"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="56704" checksum="E514B04DD6586380" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0D1</accession>
    <name>A0A194X0D1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_651608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067769.1">
        <property type="nucleotide sequence ID" value="XM_018212172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0D1"/>
    <dbReference type="STRING" id="149040.A0A194X0D1"/>
    <dbReference type="GeneID" id="28821898"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651608"/>
    <dbReference type="InParanoid" id="A0A194X0D1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="80"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="616" mass="68906" checksum="7D2CB8D26A9CD8FE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0I0</accession>
    <name>A0A194X0I0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydroquinate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_785158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067819.1">
        <property type="nucleotide sequence ID" value="XM_018222861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0I0"/>
    <dbReference type="STRING" id="149040.A0A194X0I0"/>
    <dbReference type="GeneID" id="28832587"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785158"/>
    <dbReference type="InParanoid" id="A0A194X0I0"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="44773" checksum="3C7B7380D6AD989C" modified="2016-10-05" version="1">MTAQETFRPTFPHATDNPYPRLTYGLPFYEACAKHLKETFHSQRPYIIASNTLSKKTNFLSQLQQALGDGLAGTWIGIKAHTPLDDLLPILEDMRTKNADSLITLGGGSLSDGGKAIIYALANNVFTEDDFVKLGNRKDLASSGPDMNAPSIPLICIPISLSGGEYSKYAGVTDPKSHLKIMYGHERMFPSLVILDPELTISSPERLWLSSGVRSIDHCVEGYLSTNAKPSSSTALLEALSLLVKGLLETKKNPEDLEARLNCQLGSNLSMTALYEGVWKGASHGIGHQLGPQGVGHGETSCILLPAVCKYNKRVNTGQQEELKKVLATEEVVRRVSSEAGLDMEKADLGDVLRAIFNALGMPKSLKEVGIGREKLDEVAENSLQDHFCRTNPIPIDSKEKALEILEMVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Z2</accession>
    <name>A0A194X0Z2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_651757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067887.1">
        <property type="nucleotide sequence ID" value="XM_018212179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Z2"/>
    <dbReference type="STRING" id="149040.A0A194X0Z2"/>
    <dbReference type="GeneID" id="28821905"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651757"/>
    <dbReference type="InParanoid" id="A0A194X0Z2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="530" mass="59972" checksum="833F7600804D4C64" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1Z1</accession>
    <name>A0A194X1Z1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_687298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068364.1">
        <property type="nucleotide sequence ID" value="XM_018215466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1Z1"/>
    <dbReference type="GeneID" id="28825192"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687298"/>
    <dbReference type="InParanoid" id="A0A194X1Z1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267722" evidence="8">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ14009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="242" mass="26963" checksum="9D6809F2C93EE661" modified="2016-10-05" version="1" fragment="single">MHLGIINFIKGLLGLASSKPNPAFKDDDDNKYIRGPIGNRGPCPGLNSLANSGYIPRDGKNITQAHLANALETALHMTPTLSAVLVNSVKPLLRKDGTFDLVDVRIHNVLEHDGSFTRHDIVQGDNFSLQPTYFEALLKDANNGPLTLKSLAKTFRRRHKESREVGSPRLPLHLWFVSVAEAVAFFHGSQLGKELPLDHVRTFYLEERFPDAVLENKKSRTVPGLGLDALELLFYAYIMPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X215</accession>
    <name>A0A194X215_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_784731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068242.1">
        <property type="nucleotide sequence ID" value="XM_018222814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X215"/>
    <dbReference type="STRING" id="149040.A0A194X215"/>
    <dbReference type="GeneID" id="28832540"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784731"/>
    <dbReference type="InParanoid" id="A0A194X215"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ13887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="686" mass="76165" checksum="3B244400056C390C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2W3</accession>
    <name>A0A194X2W3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068880.1">
        <property type="nucleotide sequence ID" value="XM_018213245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2W3"/>
    <dbReference type="GeneID" id="28822971"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671863"/>
    <dbReference type="InParanoid" id="A0A194X2W3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="27086" checksum="9754D4FCEFEFFF59" modified="2016-10-05" version="1">MQSHMPEDDDVLPATYGTMNPGFNPMLDIPVSRSQPDDPTETSGGSRRDPSIKGATRDAEELAVITEVPPHETRLEDKLFDAVKVRPQVPESYFIPPEEIRRLVTIDSILSELQRCGIGFAQTELQQKAEEIARTARNLFAVLVCHELGECILDFLNEGVCDEDMPFVRVRLEKRDGRAGRGLFKLESRRHKGRVLKCMATTKWTRANLEGLLRDQCWVLEPKEQEGAQADEEGRASKPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X308</accession>
    <name>A0A194X308_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_143305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068923.1">
        <property type="nucleotide sequence ID" value="XM_018205329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X308"/>
    <dbReference type="GeneID" id="28815055"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_143305"/>
    <dbReference type="InParanoid" id="A0A194X308"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267826" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15979" checksum="A53F7DB3545E9EA9" modified="2016-10-05" version="1">MKVLFTVFALVAILAAWVVASRLGHNNSSTLSTSYIPPYNNIGQHLATFQKHQTSGRCYYFINTFTRESCSCGCNCPRSIDWSGFLGLFRCVHSSMLYVAEPFDAKRRWTYMGRKGRKGRAGCRNVDAVRLEGCWMFGIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3B1</accession>
    <name>A0A194X3B1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Utp21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_650045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068667.1">
        <property type="nucleotide sequence ID" value="XM_018212089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3B1"/>
    <dbReference type="FunCoup" id="A0A194X3B1">
        <property type="interactions" value="1141"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3B1"/>
    <dbReference type="GeneID" id="28821815"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650045"/>
    <dbReference type="InParanoid" id="A0A194X3B1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Putative snoRNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="64"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="700"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="830"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112800" checksum="01EBCBE6F73F3D41" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4P4</accession>
    <name>A0A194X4P4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_750399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_750399"/>
    <dbReference type="InParanoid" id="A0A194X4P4"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="37056" checksum="9A2ED0EB65CDB1EA" modified="2016-10-05" version="1">MAQPSATTPLTTFTYFPRLAIELRQMIWKLTLQPRVVELEFGNIGFEDQDSLDSSFESYGGENDEDDRVELNSRKGFYTTTRNPIVMEVSRDSRNAVLHLYPKCFGSLWYPKCTRFNMAIDTLYIGSGLCKVVPLFFGILSKEERHGIQYLAFNRHDFDCNCLDLENILSGPGFLKRLKHVIEHMKSLREVLMVEPIECWFDTEIQGFGQWIVHSDPSFSNEISLHDTIPGIFDWLEWNLPNSTEFTKDWKVNQRVVLGWRNNIKFVLFPDNLEVLEKAQAISVAKPARLDDVRGNYYDSLISRMTTSLRVLGDRILTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4Q0</accession>
    <name>A0A194X4Q0_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_104605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4Q0"/>
    <dbReference type="GeneID" id="28814758"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_104605"/>
    <dbReference type="InParanoid" id="A0A194X4Q0"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13134" checksum="064B4883BAE83859" modified="2016-10-05" version="1">MPHSSSTTTTTTTTTTTETKMAPQVNGEAPSSAFLHHLTSLTHTSYSKISAPLAPYLHTPYSYLSPYLSKADSLGDSTLSSLDSKFPLVKKPTGELYDEGKAIVFYPLKKGNEGKEDGWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4V9</accession>
    <name>A0A194X4V9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_698094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069568.1">
        <property type="nucleotide sequence ID" value="XM_018216957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4V9"/>
    <dbReference type="GeneID" id="28826683"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698094"/>
    <dbReference type="InParanoid" id="A0A194X4V9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="628" mass="68391" checksum="DA2C51AEB9C79148" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X587</accession>
    <name>A0A194X587_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_110461</name>
    </gene>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11254" checksum="06A0AE19C6DF19B1" modified="2016-10-05" version="1">MEDLKHNSASSEHVESYELSNSKNPNQDQDADLQAYATDFAQRDPEWHSYKTKHLLKKIDLHLLPWIVLMYLTNFLDRTALAQARLGTLVQDLGLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7V4</accession>
    <name>A0A194X7V4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_697492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070598.1">
        <property type="nucleotide sequence ID" value="XM_018216908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7V4"/>
    <dbReference type="FunCoup" id="A0A194X7V4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="28826634"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697492"/>
    <dbReference type="InParanoid" id="A0A194X7V4"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="95"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="41627" checksum="E71E66FA423D3961" modified="2016-10-05" version="1">MSPAAIAVPVKANQTTKVPTGQLSGAFLDLAPIDYGLEAEKEGKDGVAPAKYPHYLPTWPNVKWAPLEPFHHCDPGLDTDPSYPELLATGVKSLDLTPSIGTEIQGIQLSKLTPAGKDQLSRFVAERKVVVFRDQDLADLPIGDAVNFVRYFGRPHLHPLSGAPKGHPEVHLVHKAAGDKTAEQFFKTKISSVLWHTDVSYERQPPGTTFLMMLDGPSSGGDTLYVNTAEAYNRLSEGFKERLHGLKALHSGFDQASAHLRKGGIIRREPIMSEHPVVRTHPVTGEKSLYVNPQFTRSIVGYKQEESDALLKFLYDHIAYGSDFQMRARWEEKTVVVWDNRVTLHSALLDWKAGARRHLARIAAQAEAPFETPYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X837</accession>
    <name>A0A194X837_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_685299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070629.1">
        <property type="nucleotide sequence ID" value="XM_018215057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X837"/>
    <dbReference type="FunCoup" id="A0A194X837">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="GeneID" id="28824783"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685299"/>
    <dbReference type="InParanoid" id="A0A194X837"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="155" mass="16409" checksum="6CDF9177B86E9998" modified="2016-10-05" version="1">MCSADIFLGLIAILFPPLAVWVKTGLCSADSLINICLCMLGYIPGLLHAWYIIAKFPEPDYYEPIPGDAEGGRVTYIVVQGPNGGTQRVPARQQGRQQGGNGTAQGYGTTATMAAPVHQEPNGTWTNAAEGSSNGAVPPSYEQAVQGDNKIQSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8A7</accession>
    <name>A0A194X8A7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_586714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070755.1">
        <property type="nucleotide sequence ID" value="XM_018209383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8A7"/>
    <dbReference type="STRING" id="149040.A0A194X8A7"/>
    <dbReference type="GeneID" id="28819109"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586714"/>
    <dbReference type="InParanoid" id="A0A194X8A7"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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            <begin position="19"/>
            <end position="47"/>
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            <begin position="131"/>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="637" mass="72608" checksum="A2E1396DA98EB3C1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8B0</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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    </dbReference>
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            <end position="808"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="808" mass="90644" checksum="81CF4D1CB69D59E1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8U0</accession>
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        <recommendedName>
            <fullName evidence="2">Transposase MuDR plant domain-containing protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_87593</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="125347at2759"/>
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            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="363" mass="39162" checksum="ED4B2CF8B02A5CB6" modified="2016-10-05" version="1">MPPLHLRQEFPTLKAFKEALHAWAIEAHFEPRILKSDTGRVRVGCKRDPNCPFVIRCNWERKNGREPLARVTVLRDRHTCLNALEWRSAGGGGGVGGGGGGMGMPVQMSAAGMVGGMVGQMPGLEIRQDEDGNIVGGARVLGPMPPKQTQQQQQQQQQQQQDPNGVVVPVLPKVQRNSASRLPFLMEILPRLMSISKETTPVEIRECLLREYGAEVHLQQCRRAKTEILKKRAEGGGGVEGQQVGVEMETGQGQQGGGGQSLDGMGGSESAGDGNTTLFGSELNQGSNGMNGVNVNVNGEAAHQQGFELHTASGVVIPQVPSRREAALNAVGEQPVRCPYCVNHRWLNSIKDAVEHMSMHVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA52</accession>
    <name>A0A194XA52_MOLSC</name>
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        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">LY89DRAFT_782257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA52"/>
    <dbReference type="GeneID" id="28832288"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782257"/>
    <dbReference type="InParanoid" id="A0A194XA52"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="553" mass="63127" checksum="84F6BCE77C744F91" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAH7</accession>
    <name>A0A194XAH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_685102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Hydantoin permease"/>
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        <property type="entry name" value="Pur-cyt_permease"/>
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        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
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        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
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    </dbReference>
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        <property type="entry name" value="Transp_cyt_pur"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ17170.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="571" mass="63908" checksum="350C1F038310C468" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB32</accession>
    <name>A0A194XB32_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
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    </dbReference>
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            <dbReference type="EMBL" id="KUJ16962.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="507" mass="57024" checksum="86351B9B47E0A97F" modified="2016-10-05" version="1">MPSVWQRFKASFFPANVSTYAAAPTIKVRQEGLAGRASPPPGYDEKKIVVTEESTQAERTTRRKPNAFDKVTKLAGSSVVVFVMLGILVLWLVMGLVYGTTDTWQIILQNASSIQVYVTDILLIRQASNANQSLMITIAELQSRNQTCERLLAMIPGCQWMETHKEEPKKLLLNGRPIEDEVEESLFMVTGRQSRIRTAWNKTCHTIAIGVGSLYAFIIYWIGICVWIAIGPAYQFSDTWQLYINTATALSLTITSVFLQNIQQQQEDKLEKCLEYALKIDAEVEYKLRELTEDEKPNLIFEIAAPKRNRSERAITRFAETMGSGLGVLISLAATAAWIAIGPLLEFNDNWWLIIGTFTGLVGFIDGFVLRNLYHRDEKYAKTQFRFLELSDMKLLEKLNVPPPNRPRDQRSLSTRISIAVGDACGHRFTSIGAVFIVVALLVIATILRWSETGQLLCNTPTMIAEGFLLLVLIQAHNIANVERGEDFNGVLKRRLMLNSYVHAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB36</accession>
    <name>A0A194XB36_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_733239</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB36"/>
    <dbReference type="GeneID" id="28829504"/>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51657" checksum="75DBBCA1BCEF69AF" modified="2016-10-05" version="1">MATPTKIHLTPETAGVINLKLQTSETAAKTSELLQENHEQNHIFFNQEGFHNHIVHHLLTLYGLGASKSQIERAFKDNTNYQRPATAVKERVVEDMSNPDHFKKYLGKEKYYHDFLIFFQTEMEKKGWENTLKEFLFAGDERADDILGRMYAGFLHPIIHLGFGIEFKQPAIICEALAQACVHDLWTSKYLLAVEKAIQSNPPKPTSATIPGLLTAIRTDKKLSTAAEWNDGNKIRDGILVRAPSEMISYASQWVASPSTLKQQTVEMTNSAIYFTAAAQKPPKQVKFDFYYMHCVNSSIFFQTFFALPFLSEENKCRMLNFKVWLDLAMYASRRSPALLQEEISTYVPAKLPAETAVTNGHGTAKDTEWPGIFERLFEFGDDGHAVKLGRAVRNGEVVSEGFEGEGWCKVKGFMWEKIGNMVVDSVEAPGATWARSVGFDEAWEEYEDRPRMAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBB9</accession>
    <name>A0A194XBB9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_734043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071407.1">
        <property type="nucleotide sequence ID" value="XM_018219871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBB9"/>
    <dbReference type="STRING" id="149040.A0A194XBB9"/>
    <dbReference type="GeneID" id="28829597"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734043"/>
    <dbReference type="InParanoid" id="A0A194XBB9"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268045" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="326" mass="36556" checksum="135079747F6E5C4E" modified="2016-10-05" version="1">MTKLTKLISFVSVLPLLQASIIPFQTPLRSSSDDEDDTPLPLVIWHGLGDNYAAEGLAEVASLAESTNPGTLVYIIRLDEDSSSDRSATFFGNLTLQLEKVCADISAHPILSTAPAIDALGFSQGGQFLRGYIERCSAPPVRSLVTFGSQHNGISEFQSCGATDWLCKGAQGLLRSNTWSSFVQSRLVPAQYFRDPMQYDDYLLYSNFLADINNERELKNQTYKENLAKLEKFVMYIFEDDTTVHPKESGWFAEVNGTEVTALKERTLYKEDWLGLKELDEKGALEFKTTDGGHMSLSEELLTDVFKKYYGPYGKKFESEVWKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCF9</accession>
    <name>A0A194XCF9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_781637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071787.1">
        <property type="nucleotide sequence ID" value="XM_018222499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCF9"/>
    <dbReference type="STRING" id="149040.A0A194XCF9"/>
    <dbReference type="GeneID" id="28832225"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781637"/>
    <dbReference type="InParanoid" id="A0A194XCF9"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="380" mass="40153" checksum="64FD2048F4F50415" modified="2016-10-05" version="1">MMADIPHRKPMPVGYQGPQPSNLYSHSRTRTTSSNTFPAPIYPPQPQQLYPSNMQVQSYTSRRTPSTATFSTASSGNGPVPFRQSSQDLRRSISSRSGGLSQPTGYVALMRKQKATVWCDRAQHEDPRLLAQQKAAKVRATMEVIGGPTASGTRISSSSSGNLAGSNRVTAKIRHHGKAGLVGYSPGDLVGGVGGVPMRLSASEVEGGDSDDDADSGNMPHTGPYHRRTGSGRSSVGSGGRRGLTYSRQSGASSIHGRWSSGNTPPSERQDSMEDVPEAGETPVPGTHGQSKDYFTADGGADGTRSVGSGSSGERADNVAELGTNDAARLAANSLMKATITREKSVKNPEELRRRGSVDERTMTMSAGRLYIANPDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCJ9</accession>
    <name>A0A194XCJ9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCJ9"/>
    <dbReference type="STRING" id="149040.A0A194XCJ9"/>
    <dbReference type="GeneID" id="28824497"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683872"/>
    <dbReference type="InParanoid" id="A0A194XCJ9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="100" mass="10638" checksum="FB406608E07F789D" modified="2016-10-05" version="1">MEGAFTHLGNHLISDSAAAINAGADDLSNIDPDESLLYGQYGGRGGLGPTRRRNDDDDNETEVFDEDDAESMASMPLDGMKTLGLRGVEDEKELPAHACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCP3</accession>
    <name>A0A194XCP3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072276.1">
        <property type="nucleotide sequence ID" value="XM_018219706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCP3"/>
    <dbReference type="GeneID" id="28829432"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732629"/>
    <dbReference type="InParanoid" id="A0A194XCP3"/>
    <dbReference type="OrthoDB" id="3440059at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="19637" checksum="FEB7A72607F57AA2" modified="2016-10-05" version="1">MPVLSESTASNHGDAPCSSSSSIFSSPAMPHVLAAFVLISCVVILIRRRTSSNKLPPAQIEHFNDEKKYEYQEPLLRMPRPASPTLAETNLTNVRNLESVPSVSPSTSIVESFEPQQQQLQIDIPRRRSYTKTIGVEKEIEVTGEIVVSPEGWRRHTRVFGGGVCKACEESERRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCY4</accession>
    <name>A0A194XCY4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_732717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072374.1">
        <property type="nucleotide sequence ID" value="XM_018219722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCY4"/>
    <dbReference type="GeneID" id="28829448"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732717"/>
    <dbReference type="InParanoid" id="A0A194XCY4"/>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268146" description="Extracellular membrane protein CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="98487" checksum="0E9354B78FBD4A72" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDQ8</accession>
    <name>A0A194XDQ8_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Histidine-phosphotransfer domain, HPT domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_717868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072641.1">
        <property type="nucleotide sequence ID" value="XM_018218375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDQ8"/>
    <dbReference type="STRING" id="149040.A0A194XDQ8"/>
    <dbReference type="GeneID" id="28828101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717868"/>
    <dbReference type="InParanoid" id="A0A194XDQ8"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000007">
        <property type="entry name" value="Multistep phosphorelay regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01627">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17233" checksum="37F3E23F9AF2279B" modified="2016-10-05" version="1">MPDTTHRHEEDRSEEGSVGLPDLGDSIDAMTFEQILEMDDDEDEREFSRSIVFGFFEQAEQTFEKMDDALEKKDLATLSSLGHFLKGSSATLGLTKVKDSCEKIQHYGQLKDEAGTADEPDEEKCLGLIKETLVAVKEEYAEVEKVLKKFYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE84</accession>
    <name>A0A194XE84_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_36973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE84"/>
    <dbReference type="STRING" id="149040.A0A194XE84"/>
    <dbReference type="GeneID" id="28816779"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_36973"/>
    <dbReference type="InParanoid" id="A0A194XE84"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="2">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="587" mass="66381" checksum="273DDDCB6D792B1B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFJ6</accession>
    <name>A0A194XFJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_696323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073293.1">
        <property type="nucleotide sequence ID" value="XM_018216826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFJ6"/>
    <dbReference type="GeneID" id="28826552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696323"/>
    <dbReference type="InParanoid" id="A0A194XFJ6"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="229"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="399" mass="44792" checksum="C3A60F046231EB3E" modified="2016-10-05" version="1">MSTNGELVASIEALLAEAKSYNEEQPDRVVRAKMLGMVEALHYRLESPAEAMFRQLTNYSETSAVRTLRQMGVLDKIPRQEPITAKQLAIVTGKNEEVLSRLMRILTSTGILKSHGADTFSHTPLSLAYLDTPEVEFWDLCVDEIAPVAYSLPGYMTTHKPDSILNPRLSPYSWANNSEGKVFYEVLLDHPDRLKRFNTAMTTQENALPVLGMFPFASLLDKSADHDRPFIVDVAGGKGQSLLQIKKELEAAGGDMGRGRVILQDRKAVLDAVPDEQLLGIEKMIIDFFEPQPVKNAQIYYLRRIMHNWQDAECLTILHNIASAMAPDSRLLIGEMVVPEKPEGVDKTVYWMDLCMLIIGGKERSQKEFSELLDSAGLRLVKIWRQMVGSQTVIECLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG17</accession>
    <name>A0A194XG17_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_477771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073473.1">
        <property type="nucleotide sequence ID" value="XM_018207822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG17"/>
    <dbReference type="GeneID" id="28817548"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_477771"/>
    <dbReference type="InParanoid" id="A0A194XG17"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268195" evidence="1">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="12116" checksum="76CC5479753C9C81" modified="2016-10-05" version="1">MPKKMRHNTRLLIAHVLIWTSQLQMALLFGATTEFDMMDNWNSEECNKVADRDDISDLRITENRGLPSEMHAELYENPATIQTMDRPFFIQAPISQESSLRQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGF4</accession>
    <name>A0A194XGF4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073603.1">
        <property type="nucleotide sequence ID" value="XM_018219593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGF4"/>
    <dbReference type="GeneID" id="28829319"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731656"/>
    <dbReference type="InParanoid" id="A0A194XGF4"/>
    <dbReference type="OrthoDB" id="3505678at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="89" mass="10096" checksum="A275EF87C799C22F" modified="2016-10-05" version="1">MGSCMTRLKAEMVAPPSNSGNWEGLAPQRPQAYAPREPRQRQQMEKDTNGVLLGRRETASGIPGLTYDHAGRPVWREENAIRVEHRENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHY9</accession>
    <name>A0A194XHY9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_731008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074106.1">
        <property type="nucleotide sequence ID" value="XM_018219535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHY9"/>
    <dbReference type="STRING" id="149040.A0A194XHY9"/>
    <dbReference type="GeneID" id="28829261"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731008"/>
    <dbReference type="InParanoid" id="A0A194XHY9"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="245" mass="27550" checksum="34089234A26EE0BB" modified="2016-10-05" version="1">MPKITTLLFDCDNTLVLSESLAFEACAELANEILSSRDIPDRYTGPQLLSEFVGQNFRGMMVSLKAKYKYEMSDAELETYVTREEDQVIKKLKEKLQPCAGVDKELQKLDQEKKYELAVVSSSALRRVRASIEKVGQDKYFPYDWVFSAATSLEKPTSKPDPAIYLHAMKTLNKTAEECVAVEDSKSGATAAFRAKIKTIGYTGSYEPEEQEKMKKVLVDAGCAVMMNDWSEFEGCLEKIEKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI89</accession>
    <name>A0A194XI89_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_462933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074199.1">
        <property type="nucleotide sequence ID" value="XM_018207700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI89"/>
    <dbReference type="STRING" id="149040.A0A194XI89"/>
    <dbReference type="GeneID" id="28817426"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_462933"/>
    <dbReference type="InParanoid" id="A0A194XI89"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="257"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="52872" checksum="8742A819099F9A7F" modified="2016-10-05" version="1">MSAFQNGGAPSRAMDEDSDIEEEALAADYREQVQYEGMEELEQVSSMSMAQQTDDIQSRLAAAAQPLDFSAPLEVKFASYDNYCSLFHFILNSDGPVDLEPPSYYWAWDVIDEFIYQFNSFCSYRNRVARQGNNEEEITILREAPNTWGCYSVLNVLYSLIQRSQINEQLAAMKRNEEPMAVAGDYGSKSLYRMLGYFSIIGLLRVHCLLGDFSLALKTLDDIELNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILIYVSRTKNFQKNAQYDSISKKNDQMYALIAICVAFHPTRLDDTIHTALREKYGDQLLKLQRGGPESLPIFEELFRSSCPKFISPTPPDFDNPELNVDPLEHHLAIFMDEVKTNMWSPTVKSYLRLYTTMDLKKLAGFLEVEPEKLRGWLLVNKQRSRQIRWTDNGLLDGEIVNSNDLDYAMQGVRIAPSSDITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJP7</accession>
    <name>A0A194XJP7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_772767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074357.1">
        <property type="nucleotide sequence ID" value="XM_018221914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJP7"/>
    <dbReference type="STRING" id="149040.A0A194XJP7"/>
    <dbReference type="GeneID" id="28831640"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_772767"/>
    <dbReference type="InParanoid" id="A0A194XJP7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23862" checksum="805B3DC315530E5A" modified="2016-10-05" version="1">MSHPKPPNITLYFLQSSRSIRTAWLLEELSLPYTSIFFPRINNKAPPDFASRSGNSLGKAPTLVDGDITLCESGAIAEYLVEKYDEEGRMGGGGEGERERERVRMWVHAAEGTFMVHCLAVTYARWFATRGMRDSGALAELEGGLGVNVGKDLDWLERELEGRRICVQFIFARDLTAGRKVGEWKNVERWIRECEATESYKRAVKKTGHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK57</accession>
    <name>A0A194XK57_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative phytochrome-like histidine kinase PHY2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_579490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074945.1">
        <property type="nucleotide sequence ID" value="XM_018209006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK57"/>
    <dbReference type="GeneID" id="28818732"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579490"/>
    <dbReference type="InParanoid" id="A0A194XK57"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="353"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="728"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="997"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1025"/>
        </location>
    </feature>
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        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
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        <location>
            <position position="1116"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135189" checksum="CFCAE7C921D2AADB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKN2</accession>
    <name>A0A194XKN2_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_452679</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075056.1">
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_452679"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="20144" checksum="E15D23D5C998380D" modified="2016-10-05" version="1">MGGGPVGGGRRGCGSKKGQPRMKEEVRKGSGVLVARGRKQSLEIRPSQAKEYSSAVSRRDGDGRRKPVEATYETRRWRGEGGGRGTRTPGEKRPWLGLALAPGPGCEERFGGAVCFRVQAPCRSVFLACVRRRQQMMIPVSHQLCPSIFPVWAVQYCTVVSLPHPIHLTNHFSGTVEHRCANPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKZ1</accession>
    <name>A0A194XKZ1_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_682451</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
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            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
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            <end position="40"/>
        </location>
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            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ20764.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="776" mass="84878" checksum="83BD7BB9B470514C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL86</accession>
    <name>A0A194XL86_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_681570</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28824050"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681570"/>
    <dbReference type="InParanoid" id="A0A194XL86"/>
    <dbReference type="OrthoDB" id="5244524at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="24582" checksum="AA94A2AF96E5AEAE" modified="2016-10-05" version="1">MAAQGQKFSFMRTINNAVPNFARDDPNDVDLKPAQADALLTYQLALPHPRYLGENAFLVAGLVGSESLSKKVYRALVKHKIISPYPGVEKERKGSVSSMLSFGNDRASSSIEAGSGVGGEQMTVNTAGIGKRFASQLAVISVHAQRKLVGMLFFWEEECMRWKLLDEEEKEILRAVEQEGNENRDLNVALEAVEMKKKMLPSKRAEAVANVSEGQGHTLPRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL92</accession>
    <name>A0A194XL92_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075360.1">
        <property type="nucleotide sequence ID" value="XM_018219410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL92"/>
    <dbReference type="GeneID" id="28829136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729810"/>
    <dbReference type="InParanoid" id="A0A194XL92"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="136" mass="14965" checksum="10FF4BBA3D2B2B96" modified="2016-10-05" version="1">MPPVQKKVARPIEPERSIGEQDTGPIPIFMQAGHESTPDLEFTQQLLWGSGGLPALELTHSTPSASFRQHHGRERPPLPQKNVPGTHAYLEPVEQSKSLWACSRRWSDSDWGRSVAVPGNVENMDVVLMSAYNAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLZ6</accession>
    <name>A0A194XLZ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_778808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075558.1">
        <property type="nucleotide sequence ID" value="XM_018222244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLZ6"/>
    <dbReference type="STRING" id="149040.A0A194XLZ6"/>
    <dbReference type="GeneID" id="28831970"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778808"/>
    <dbReference type="InParanoid" id="A0A194XLZ6"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF3">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="130" mass="14244" checksum="8880AEB05EC6A7E5" modified="2016-10-05" version="1">MSNNATQNQEVAEASDEEVYAQSDEEEASSDAALVPQQQTQQQVAPQPRRGQRQQQQPNGLPQMSQQVQNPPARAQGYRPGAIRESRIKDRPVASSGASDSALKIKIELDLEVEVDLYARVKGDVTIGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMA5</accession>
    <name>A0A194XMA5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_418491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075257.1">
        <property type="nucleotide sequence ID" value="XM_018207387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMA5"/>
    <dbReference type="STRING" id="149040.A0A194XMA5"/>
    <dbReference type="GeneID" id="28817113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_418491"/>
    <dbReference type="InParanoid" id="A0A194XMA5"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="448"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="60828" checksum="C04AB3AC6B8B78B4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP38</accession>
    <name>A0A194XP38_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_714882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076199.1">
        <property type="nucleotide sequence ID" value="XM_018218159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP38"/>
    <dbReference type="FunCoup" id="A0A194XP38">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP38"/>
    <dbReference type="GeneID" id="28827885"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714882"/>
    <dbReference type="InParanoid" id="A0A194XP38"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="16918" checksum="E44621DA2C77FD62" modified="2016-10-05" version="1">MAGGISVRDVDAQKFIENYASFLKRQGKLPIPGWVDTVKTGPAKELPPQSIDWFYVRAAAIARHVYLRKTVGVGRLRKVHGSPKNRGSRPSHHVNASGSVDRKVMQSLEKIGVLEQDEEKGGRRITQSGQRDLDRIAQTVQESLEGDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPG0</accession>
    <name>A0A194XPG0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_576569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076406.1">
        <property type="nucleotide sequence ID" value="XM_018208844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPG0"/>
    <dbReference type="STRING" id="149040.A0A194XPG0"/>
    <dbReference type="GeneID" id="28818570"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576569"/>
    <dbReference type="InParanoid" id="A0A194XPG0"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="39134" checksum="CB5E40FF49A976E1" modified="2016-10-05" version="1">MGYTTVEMLLDDVSKQMASSNLSRYPRGPQGQRTGGSMRIVKPNSASNSPRGSAGLGRRRTVMNDGAYRRRLAMLEQQNAMAAGGFISNDGLQVPARSARPMSWHPASHLAPQPTYQQSYPLQTPEYQQQLQLFDMPPTPAVYSGYASPDSSFSPLSMPFNGYEQPQCSYPFTASTFQSQPQYLADQPQFITQQTQQIVSQNTNTDPTMYSHFDWNNFAANGFESSSTAPPTPDNFLPIQNPEPAFSAEESIPYEPLEDPESGGEELIGMGLYDSPDTVKTSSLDPQLDNYRALMMSHLMGSGHRKTESTGKGLKLEETWEPPASDDEDADDEEQDGEGEDEEVEEAPQALAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPJ9</accession>
    <name>A0A194XPJ9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076530.1">
        <property type="nucleotide sequence ID" value="XM_018219398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPJ9"/>
    <dbReference type="GeneID" id="28829124"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729642"/>
    <dbReference type="InParanoid" id="A0A194XPJ9"/>
    <dbReference type="OrthoDB" id="9971254at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5648" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="137" mass="15256" checksum="56FBFC2787E1697D" modified="2016-10-05" version="1">MADHFYTTDPHGGSAPASGYHLEEIACYVATTELKGTVPIYQWYNPSSKLHFYTTDFNGELAPQAGYEYEKIAFYAFSHEATGTVPFYRWVGSKSQHFYTISDSEGANSGMKFEGITAYVHPGATEGFAALYRRYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ65</accession>
    <name>A0A194XQ65_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">LY89DRAFT_728458</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076656.1">
        <property type="nucleotide sequence ID" value="XM_018219266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ65"/>
    <dbReference type="FunCoup" id="A0A194XQ65">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQ65"/>
    <dbReference type="GeneID" id="28828992"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728458"/>
    <dbReference type="InParanoid" id="A0A194XQ65"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 28" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <location>
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            <end position="369"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="47773" checksum="1B2C89A9D73E39E3" modified="2016-10-05" version="1">MTLHSRPPVIRVDAELLIPGRGVPIPHATLVSEGRKIVYVGKQSTLPAKYAQIEGTVVPVLLPGLWDCHVHFFGAPSFTPEVVTSTTAALAGARSARDLAATLNAGFTSVRELGGYGAQISAAVEEGWLVGPNIYSSVSMLSQTAGHGDAREEDMTMICSKMQQNMPFYLCDGEAECQKAVRTMIRRGATVIKVATTGGGSSKDELQARQFSDAELLIMVQEAQRGGLAVAAHCHGKEGIKAALRAGCRTLEHASFANDECIALMKEKDVLFVPTRTAINFALSNPKAWTPENYRKIVQLADANLRAYTKAIKAGVRIALGTDIGLSATSLPLNHGMNGKEFVWAVEAGLMPLEAIEAGTARGPESLMMNAIENGDDESDDDGEPPLTKAPKSGQLKVGFDADFIAVSENPLLDIAVLANPEKVTHVWKGGKLFKEPGKLATLILPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRM3</accession>
    <name>A0A194XRM3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_311773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077198.1">
        <property type="nucleotide sequence ID" value="XM_018206640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRM3"/>
    <dbReference type="GeneID" id="28816366"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_311773"/>
    <dbReference type="InParanoid" id="A0A194XRM3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="105" mass="12225" checksum="66F91625F1198735" modified="2016-10-05" version="1">MIYFCRYQSFLCCILMFICKSPTDTDSDIKFSLFDLRLYIFVLLRTLLNALNIVMLCYIISTCLHVPLQVRVDRPYLPGIRQYFALHLQLQPSFAPALSMSFSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS84</accession>
    <name>A0A194XS84_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_605911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077515.1">
        <property type="nucleotide sequence ID" value="XM_018210407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS84"/>
    <dbReference type="FunCoup" id="A0A194XS84">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XS84"/>
    <dbReference type="GeneID" id="28820133"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_605911"/>
    <dbReference type="InParanoid" id="A0A194XS84"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="282"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="472"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="589" mass="65174" checksum="508A3DA3679B370F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT29</accession>
    <name>A0A194XT29_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_183129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077815.1">
        <property type="nucleotide sequence ID" value="XM_018205631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT29"/>
    <dbReference type="GeneID" id="28815357"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_183129"/>
    <dbReference type="InParanoid" id="A0A194XT29"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="519" mass="56772" checksum="2C42093FE20465CC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUI5</accession>
    <name>A0A194XUI5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_726764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078054.1">
        <property type="nucleotide sequence ID" value="XM_018219079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUI5"/>
    <dbReference type="GeneID" id="28828805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726764"/>
    <dbReference type="InParanoid" id="A0A194XUI5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="214" mass="24218" checksum="2307A0F2DA78F907" modified="2016-10-05" version="1">MNITSKATQATSSHTKALWSRKNVPRPDDMINIIKDVFQSPKELSTAATSAVNMQGNKVAEDAHYVNKKPTCSSARTLRFDGASDDHDIYTKKSSEKPVHQGNNRIRNYIFHSIPNVFTTGLRPTIAMIDIPVSDLWGKLSNYLDPLPFFCYYHPDHGHIDICLLFSSNVERIDIDLCVSPSNPESLNDTSGMAAFFNYYFQLFRKISYKDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV29</accession>
    <name>A0A194XV29_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078244.1">
        <property type="nucleotide sequence ID" value="XM_018213820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV29"/>
    <dbReference type="STRING" id="149040.A0A194XV29"/>
    <dbReference type="GeneID" id="28823546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679175"/>
    <dbReference type="InParanoid" id="A0A194XV29"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="129"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="388" mass="43041" checksum="2EB7238565CDDF34" modified="2016-10-05" version="1">MAPLASIFKKAYYTLFFGIILYVSALFALTNPWLQRHALYVHKLHTAYWVDHNVPEQFGFAKNQITPFNFLTPDHETIYAWHVLPLGLYARHEAEMLRQPSGLSEDITQMKSFQLLRDDPDSRLIINFHGNAGSVAQGWRTDCYRSLSDGSTSNIHILAIDYRGFGLSTGSPTEDGLIIDGVATVDWALNVAKVPASRIVILGQSLGTAVTAGVVEVFAQRGVDFAGVVLVAGFSNLPDLLTKYSIAGYLPILSPIGPYPRLKKILRDHIIDKWPSTERLANFVRLSKRVRLFILHSKNDPEIPWTESEALFAAAANATTDGGMEVELFKKMKARTTVDMGDGTFISTWKTGGDKIIREEIVAYGHHSRILTYAPVALAALKAFDFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWY8</accession>
    <name>A0A194XWY8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_727314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078637.1">
        <property type="nucleotide sequence ID" value="XM_018219138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWY8"/>
    <dbReference type="GeneID" id="28828864"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727314"/>
    <dbReference type="InParanoid" id="A0A194XWY8"/>
    <dbReference type="OrthoDB" id="3565100at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268676" evidence="2">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="344" mass="33598" checksum="EA32B2E72DC4BA29" modified="2016-10-05" version="1">MKTQTFFAVFALATAIVAVPIPNSPSSTSSALESIESLVGSPFGNGNGDGNGNAAGNNDGDNASGNGSQDGNGRHAIGSGDDFGNSNGILSGNSGLKIGRTSSSSEDLGDLISGLVGSPFGNGNGDGDGNSAGNGDDGNASGNGSGDGNGSGSNDQFGNGNDILSGNNGISLGKKVRRNPSPETPGTYVGNIIDAVVVPLEPGSSDSVIGSPSDNGNSDGDNNSAGNGDDGNASGNGSNDGNNSGSNDNIGNGNDILSGDCGVCTGAITVRDLPDDALDLIPDQSVTSLNQDFSQVFSDGPTDVAGAISGALSGDDTSETFNGKRQVLTGLEDLIADDVVAYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX10</accession>
    <name>A0A194XX10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_745532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078954.1">
        <property type="nucleotide sequence ID" value="XM_018221071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX10"/>
    <dbReference type="GeneID" id="28830797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_745532"/>
    <dbReference type="InParanoid" id="A0A194XX10"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="87"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="45111" checksum="4CE7D7C08FD18FF4" modified="2016-10-05" version="1">MEESTNPCFESSSNDSNPNSNCGSPLSSHSSTYDDVKEVPSLSLSPMAWNGEDLKPKDYVFELRDHDVAAISEAVVHFKNIGVPAEKVGPETFPLPVELAPRLGNIASSLYNGIGVAVRRGIDPMMYNDFDKALVFAGVSSYVCSQRGTDDFASIIYTIVNIQLTVTQGHIRDATHDHVPEAAKGVGLAGSKIPVALSFHADRFAGDILALFVVDQGSEVGGGEQFLSSFWRIYQELLVTAPDVIKTLEAEARPWEIADPITHEAGVSFAPALFYAAEKPMMQLVHAVLTGGPQLPRPDHLPSLSAAQHHALRVLEKTAQKFSHKLDRQDGDIQFVNNLSIMHARAAYEGDELSSRHLLRMFLRDPKNAWHCSGKHREAFDKVFSPDRQQEFVVKDLDPWFKIQGKNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1Q3</accession>
    <name>A0A132B1Q3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_769813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947450">
        <property type="protein sequence ID" value="KUJ06221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060576.1">
        <property type="nucleotide sequence ID" value="XM_018221835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1Q3"/>
    <dbReference type="GeneID" id="28831561"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769813"/>
    <dbReference type="InParanoid" id="A0A132B1Q3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="16653" checksum="0067C892D31488A9" modified="2016-05-11" version="1">MVKRTIRSFSRSATLSKTDPSPITSGSTAMKRKRSNTSSEKTSLVSVSDASGSVTGHASSQNTPTRRPKRQRNTARQHLDDEIRRLRGSVPTIEELIAEAEREHAAIREKREREMESIWRRRNDLVGLKEYLQTWGAQDKEWTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B246</accession>
    <name>A0A132B246_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_692441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060820.1">
        <property type="nucleotide sequence ID" value="XM_018216539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B246"/>
    <dbReference type="STRING" id="149040.A0A132B246"/>
    <dbReference type="GeneID" id="28826265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692441"/>
    <dbReference type="InParanoid" id="A0A132B246"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="94"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="25762" checksum="CA2AC386DE751CA2" modified="2016-05-11" version="1">MPSQPKVLFVLTSHSKMGDTGKPTGWYLPEFAHPYEVLSPHTQITVASPSGGEAPLDPSSVEAFKADAISTKFLSHQESLWKNTQKLESFLGHAGEYEAIFFVGGHGPMWDLANDETSHKLINEFYAHNKIVSAVCHGPAAIANVKLPSGEYLIAGQAVTGFSNSEEDAAGLSQYMPFMLETALDKASGGKFVKADDWAKKVVISRGGRLITGQNPASAEGCGQAIYDAIFGELTTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3P7</accession>
    <name>A0A132B3P7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_632449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061014.1">
        <property type="nucleotide sequence ID" value="XM_018211305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3P7"/>
    <dbReference type="STRING" id="149040.A0A132B3P7"/>
    <dbReference type="GeneID" id="28821031"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632449"/>
    <dbReference type="InParanoid" id="A0A132B3P7"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="180"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="643" mass="71050" checksum="3C8AA981377D4ABE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4E8</accession>
    <name>A0A132B4E8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_712093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061621.1">
        <property type="nucleotide sequence ID" value="XM_018217952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4E8"/>
    <dbReference type="GeneID" id="28827678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712093"/>
    <dbReference type="InParanoid" id="A0A132B4E8"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
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    </dbReference>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="142"/>
            <end position="260"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30422" checksum="D452F7E752F4C908" modified="2016-05-11" version="1">MGPKKPHSTTKPPSKSSTPPTPPTNWPIFKPLLPVSDLSLQTLVPSQIITIPYFWTSTLCKNYVNFLKTLPLTTTPVKPKKGDALRFNDRFQVIDERFANRLWEESGLRELVCGSGDENEGDEERMSDNERRELWGGEVVGLNPSIRVYRYSKGQFFDQHYDESNVLTLNTKPSPTPVRTTWTLLLYLTSPATGCQGGETVFYPGDLQIPGRKTVVEKEIVVGLETGMVLLHKHGNDCMLHEGRAVTDGEKWIIRTDLCVKREKSRFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4L3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="28826136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691805"/>
    <dbReference type="InParanoid" id="A0A132B4L3"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="83" mass="9271" checksum="3C8F2FC8F5303AFC" modified="2016-05-11" version="1">MAGSFNVCIPVRVNSAKSHSKRVIIRFPLPYKVGDLQHPGNAEEKIRSEAATFIWIRENCPTVPIPYLWGFGLPDGKSVCDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V6</accession>
    <name>A0A132B4V6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_743060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="707"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="789"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="872"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="931" mass="102380" checksum="20F2D43EEDDB4204" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5I1</accession>
    <name>A0A132B5I1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_742439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062023.1">
        <property type="nucleotide sequence ID" value="XM_018220823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5I1"/>
    <dbReference type="GeneID" id="28830549"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742439"/>
    <dbReference type="InParanoid" id="A0A132B5I1"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="20532" checksum="43D8F25610623960" modified="2016-05-11" version="1">MTQQRANILNEFYAGASGRSDGFRYYKNASTLPLEIALIIQKLALHKKTALWRKCKLQTFFAKKQHIRYFVVDDTKEATRASDASTKSLDSGEADFFKLVDEDVAVAEADAKAEANIVHGFDSHRSAVIPWLRRTGIEEHTRGLKKDEMHASFVVPKIAESEPELFLMLEIMDEIFIEAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6A3</accession>
    <name>A0A132B6A3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_742553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ07783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062138.1">
        <property type="nucleotide sequence ID" value="XM_018220838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6A3"/>
    <dbReference type="STRING" id="149040.A0A132B6A3"/>
    <dbReference type="GeneID" id="28830564"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742553"/>
    <dbReference type="InParanoid" id="A0A132B6A3"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ07783.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="307" mass="32988" checksum="C92D15EAE8147B8B" modified="2016-05-11" version="1">MSLEEVQKVAPPPWKSLVAGCAAGAVEGLVTYPFEFAKAMLQFAPNAKNSPSTAMVCHAFSILLSLSVVSNPFVLVYKTAAERGIPALYVGCSTVVLGTALKASVRFLAFDSIRGVFEDEQKRLSGGRALLAAMSAGVMESVLVVTPFETVKTALIEDAKRARPQYRGMIHGTISLIKETGIGGVYRGVSAVTMRQVSVSFARMLSFSSMKAILQSGQTDQNANLGRGTTFAIGALAGVFTVYSTMPFDTVKTRMQTLEAKSQYTSTVDCALKMLKNEGASVFWRGSTARLGRIVVGSSFFFLWIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6W3</accession>
    <name>A0A132B6W3_MOLSC</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="515" mass="58147" checksum="AE9049CC29C88F48" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6W4</accession>
    <name>A0A132B6W4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="10" type="ORF">LY89DRAFT_336286</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B6W4"/>
    <dbReference type="GeneID" id="28816550"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_336286"/>
    <dbReference type="InParanoid" id="A0A132B6W4"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
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            <end position="51"/>
        </location>
    </feature>
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            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="167"/>
        </location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="732" mass="80961" checksum="C925CAB3287979B8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6W9</accession>
    <name>A0A132B6W9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6W9"/>
    <dbReference type="GeneID" id="28825952"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691064"/>
    <dbReference type="InParanoid" id="A0A132B6W9"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="28663" checksum="E0A439F605FA4CD2" modified="2016-05-11" version="1">MAYAANVIRGDDPSTTKLYGERTAKTSCQYLLPHVTKSAKILDVGCGPGIITADLAKIASDGSTIGVDNSEGIIKQASTSFPDVPNLKYQVGDATNLKDFADNSFDIVHAHQLLVHISNPVPVLKEFYRVCKPGGIIAVRESSPSVVLFLKPDLPGIRQYWDRAMAMMPKIGAQTQAGIDLEKWAKEAFGTDGEKLVYTKTPVWNAGHTERVTGPAAAHAIQYGMATQEEMDQWAEAWKEWDAAEDHEWVFEAGEILCRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6X5</accession>
    <name>A0A132B6X5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_601544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061782.1">
        <property type="nucleotide sequence ID" value="XM_018210204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6X5"/>
    <dbReference type="FunCoup" id="A0A132B6X5">
        <property type="interactions" value="1253"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6X5"/>
    <dbReference type="GeneID" id="28819930"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601544"/>
    <dbReference type="InParanoid" id="A0A132B6X5"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ07427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="22507" checksum="8F591CA6EED06D0B" modified="2016-05-11" version="1">MKLHYIGIIKNQEKPAHELCAEKDLSAYSRFTRNNYGEFMTLFSKTVAERTRPGQRQDVEEQDYTFHAYGRTEGVAGIIISDHDYPALVAHQLLSKVVDEFLAKHPRSSWATSSPTLSFPELKDYIVKYQDPQQADSIMKIQKELDETKIVLHKTIESVLQRGEKIDDLVAKSDGLSAQSKMFYTQAKKQNSCCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7K6</accession>
    <name>A0A132B7K6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_536914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062588.1">
        <property type="nucleotide sequence ID" value="XM_018208111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7K6"/>
    <dbReference type="FunCoup" id="A0A132B7K6">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="GeneID" id="28817837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_536914"/>
    <dbReference type="InParanoid" id="A0A132B7K6"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="33"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="204"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="475"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="907"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="965" mass="107601" checksum="F1548FA7B094CBC9" modified="2016-05-11" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7R8</accession>
    <name>A0A132B7R8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_676867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062805.1">
        <property type="nucleotide sequence ID" value="XM_018213639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7R8"/>
    <dbReference type="GeneID" id="28823365"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676867"/>
    <dbReference type="InParanoid" id="A0A132B7R8"/>
    <dbReference type="OrthoDB" id="10639834at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="278" mass="31532" checksum="4E2E9ADF051A3F34" modified="2016-05-11" version="1">MSREWKKKPAPTEQYVKMDVCLCLRSFVVRVQGTLFELVISQALHGCKLYGLSGGCAMQIECTLTHGGGVSRGNVSVEERLLGRGHEFMHEHERGAMLAYLPPWALGFMAQWWERGGGESRIPRLKPAVVVLKLFLYNLRLLCDPSRPFWAYVSCRLSSPNCDFMGRWFQAATQHDNQTHQILDCQLGPTNWRSKVQGCHSRTSGIKVYDLHGLQRLTEAAMNYDLRCSARLTELSMLSQATEFTGWWLKTNTMPDLDSWGCIVPVFNNGAWCLNKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8C4</accession>
    <name>A0A132B8C4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_676572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063013.1">
        <property type="nucleotide sequence ID" value="XM_018213603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8C4"/>
    <dbReference type="GeneID" id="28823329"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676572"/>
    <dbReference type="InParanoid" id="A0A132B8C4"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="737" mass="83742" checksum="F25539D175A38B43" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8K7</accession>
    <name>A0A132B8K7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_338204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062569.1">
        <property type="nucleotide sequence ID" value="XM_018206839.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8K7"/>
    <dbReference type="GeneID" id="28816565"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_338204"/>
    <dbReference type="InParanoid" id="A0A132B8K7"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="461"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1318" mass="149260" checksum="CD4A4E47384FE09A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8U8</accession>
    <name>A0A132B8U8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_724910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062774.1">
        <property type="nucleotide sequence ID" value="XM_018218940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8U8"/>
    <dbReference type="STRING" id="149040.A0A132B8U8"/>
    <dbReference type="GeneID" id="28828666"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724910"/>
    <dbReference type="InParanoid" id="A0A132B8U8"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="62369" checksum="B4527B6981F4C5F0" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8V8</accession>
    <name>A0A132B8V8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_658553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063193.1">
        <property type="nucleotide sequence ID" value="XM_018212479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8V8"/>
    <dbReference type="STRING" id="149040.A0A132B8V8"/>
    <dbReference type="GeneID" id="28822205"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658553"/>
    <dbReference type="InParanoid" id="A0A132B8V8"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="27548" checksum="AF8893362A243FAB" modified="2016-05-11" version="1">MSSNATLPDLAKAGISLPNTPLIRGALGHLKKYTSPTTVNHCIRSAYFAILLSRKIPRSSSEPLDVELIVFSTIMHDLGWATDKTLLSKDKRVEVDGANMARSYLEEVKLSNGWDKHRTQLMWDAIALHATPSFALHKEAEVKIAHIGIMADFWGPNYPGYPITIEENKEIVDAFPRLGFKEQFLDIMCGLCALKPGTTYDNFVADYGVEFGLDGKGTDKEDFAKKRFALSSPQIFYPAIGSYEQDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA78</accession>
    <name>A0A132BA78_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_690359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063667.1">
        <property type="nucleotide sequence ID" value="XM_018216083.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A132BA78">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BA78"/>
    <dbReference type="GeneID" id="28825809"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690359"/>
    <dbReference type="InParanoid" id="A0A132BA78"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1500.20:FF:000001">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="326"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="610"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ09312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1289" mass="143944" checksum="3FC1A9DDF976331D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC80</accession>
    <name>A0A132BC80_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_787675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064351.1">
        <property type="nucleotide sequence ID" value="XM_018223092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC80"/>
    <dbReference type="STRING" id="149040.A0A132BC80"/>
    <dbReference type="GeneID" id="28832818"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787675"/>
    <dbReference type="InParanoid" id="A0A132BC80"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="470" mass="52037" checksum="8D0CB14667A1CB7F" modified="2016-05-11" version="1">MENWRSIDVQDAKVLIGGQHVNTGLLTIIAEGHLGKVTITGLSDTKMNKQIHGSTGLAAISVTSPDLYSIQDNPTALWVGSKSTWFSVNMAREYSKVFSSEGHSISMFFSVVDYYLEDSSRLDLPLSSQLLEIFALDIASFGTGSTLRENIRLCHKHAAFLEHHMAKEPAQIVKDGKLIEWSKTPFYEWITQDIESKTNALSNGMINLNELKDMMEFASAGNSHRNSPAEGMDGQGDVKMSDPVDEEEEYQEEEVTLPAPKVQTGGRGRVSGTHKGPYISPQLPSSSKIPDTFVEIAVAMSYHYVATNRDGKTIETLSVATVQNAIYRDYSISRPEIATRLMRDHARTIYNALLPEFKKAKIGQDLIALEPATGQIKCAKEVHEKKANEQYLRLKAGDEVLKQRGGNAVRQVREVLEVQEVREVRGGQGSVMSVASDRGSGDGFVVRRDKPGYINGKPIPQRIKRSGMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC94</accession>
    <name>A0A132BC94_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_597226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064346.1">
        <property type="nucleotide sequence ID" value="XM_018209968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC94"/>
    <dbReference type="STRING" id="149040.A0A132BC94"/>
    <dbReference type="GeneID" id="28819694"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597226"/>
    <dbReference type="InParanoid" id="A0A132BC94"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="37384" checksum="A0A87B747DAEDD08" modified="2016-05-11" version="1">MDTLDEISYLDPASPEVISRLRTIASRALCVRYHQNQADEIVMQWKSSIQQLPGKCEREPTKPMRSSKKQDSVKDESVEDMKSQIREMRELLAKLQDKQQENAEDRRKFDQGQHRQEEQARRADEKERRRRKKEQEEREAKRQEEERLEKERKDRERKEQREREQAAYSERLRQRAQKRREERERERKENEQKEKEQWSQLWTKYEARWVQFKSSASSEAALRDSIPWPVKSGSYRDVKASAVEEFFEKAVPKDSGMAKRLRKECMKWHPDSISRSPHADRFTTTDRMMADMICRVVTSLIDSSAGRSAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCA3</accession>
    <name>A0A132BCA3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_598100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063839.1">
        <property type="nucleotide sequence ID" value="XM_018210019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCA3"/>
    <dbReference type="GeneID" id="28819745"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598100"/>
    <dbReference type="InParanoid" id="A0A132BCA3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000045">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="195"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="369" mass="41959" checksum="5C5DB465119D4476" modified="2016-05-11" version="1">MATETQTRTQPEVLTFSTLPPFPADIPTAPLHRLSLSKLRSESPESERLFSSCKDLGFFYLDLRQDDEGESLLKDADNLFNLAPKLFDLGRDELQKYDYKSQGSYMGYKRFGSAVVDEKGNLDRNEFYNIPKDDFLGISSKPFAHPQVLHDHNSLITSYMRTSHSLVVFILRHIENHLHLPAETVTSLHRQMQISGDQVRFVKSPPQPPSDMRTALGKHTDFGSITILFNRLGGLQILPPPSLTPAGQEPQWTYVKPLPGHCIVNLGDAMVKFTNGLLRSNIHRVVSPPGEQAKETRYSLVYFSRPEDEVILKRLEGSDVIPELRDGEKEEEVNSKEWIKLQAMRLRNVKEGMSDEDRKKLWQEAGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEE3</accession>
    <name>A0A132BEE3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_701046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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            <begin position="604"/>
            <end position="636"/>
        </location>
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    <sequence length="687" mass="73968" checksum="52CBE84A28D0CC12" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">CBS 120377</strain>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="431"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="778" mass="88207" checksum="002636E56CCDCC1C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSM1</accession>
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        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_787026</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018223037.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_787026"/>
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    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
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    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
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        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
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        <location>
            <begin position="24"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16362" checksum="AC910847E2131509" modified="2016-10-05" version="1">MSKSHLSNDDFFLRLSELFDERRQKNHGSIHLTQKRMSYGADGDVESPEPSTAQPFPDLTPSKPLPIIIRATNGKSKEKRDKKVKLSTIVDVDALEGFYSKYAEVCKLGMSGLKKRDRSKAKEKLKAKKKKQGGAAAGGTEVKKEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTI5</accession>
    <name>A0A194WTI5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_655773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065282.1">
        <property type="nucleotide sequence ID" value="XM_018212359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTI5"/>
    <dbReference type="STRING" id="149040.A0A194WTI5"/>
    <dbReference type="GeneID" id="28822085"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655773"/>
    <dbReference type="InParanoid" id="A0A194WTI5"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="165"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="39906" checksum="2111705F76C54049" modified="2016-10-05" version="1">MLDRLNPFSGSSITSEVTELRIYPIKSCRGISIKKSYLTKQGLDMDRRWMFADAETLKFVTIRDISEMTLIDTAFASTSDSSSSAPSPLSPHGGEDAEQLVISIRHTDKKVMVPARPTDQWLQGNTELRQVDIWENMTDGYVYKDDINDVFTEFFKKGVKLVYKGPTPRILRGNGAPELLGREESTNFPDVMPLQIANEGSIRELNQRLKQKGHSEITIERFRPNIIVRGADETLTDDKAPGAWTEDSWKTVRILNGEQSTGLTSMIGAGNKGLEIDVQARCARCQVPNVDPDTAEKDQHEPWDTLVSYRRVDEGIKWKPCFGMLSAPRNEGSISVGLKFEVVETTEDHKYVKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTJ0</accession>
    <name>A0A194WTJ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_787259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065287.1">
        <property type="nucleotide sequence ID" value="XM_018223058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTJ0"/>
    <dbReference type="GeneID" id="28832784"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787259"/>
    <dbReference type="InParanoid" id="A0A194WTJ0"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267426" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="194"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="749"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1210" mass="137232" checksum="A671E49168D83D5E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTY4</accession>
    <name>A0A194WTY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065761.1">
        <property type="nucleotide sequence ID" value="XM_018215753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTY4"/>
    <dbReference type="GeneID" id="28825479"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688677"/>
    <dbReference type="InParanoid" id="A0A194WTY4"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267446" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="53" mass="6209" checksum="4751226F714BFE92" modified="2016-10-05" version="1" fragment="single">IGEILGWRLLLFTVLKEVVGPHQAQWDVDEKVLTYRDVDLHIDHVPRLLLSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTY8</accession>
    <name>A0A194WTY8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_236300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065427.1">
        <property type="nucleotide sequence ID" value="XM_018206063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTY8"/>
    <dbReference type="GeneID" id="28815789"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_236300"/>
    <dbReference type="InParanoid" id="A0A194WTY8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="182" mass="19595" checksum="7D99D7BFC20880FA" modified="2016-10-05" version="1">MTDLAQHSCSPEISLSRLSRYLLQLSPASPTPTQLICAASGSHNQLSQGPNNPNPLFLLFSFSTSTTTPTRNPPIAASTRPCATCALLLLLTIDRVGAHLHSRPRPFTFNPVPEPPANDQSRQTVTPATFSTGALTLPITTHRDISINPHDVLLSHHLLVLGSLPDCSADALSTRFPAYDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUK8</accession>
    <name>A0A194WUK8_MOLSC</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_739493</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065652.1">
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    </dbReference>
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    <dbReference type="GeneID" id="28830193"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739493"/>
    <dbReference type="InParanoid" id="A0A194WUK8"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="16710" checksum="A6ACC66BD144777C" modified="2016-10-05" version="1">MEKDTENTTIQYQPQDGTRSNHTWFDNLAIIFTIKLIFAITFIYVFPYMNNIDESYGTAVVIGYGTAFLGVSFWATSKFLDQPVQAHGRRVVHYGEGRIDWRNEKVFLSEDDETEDDDCELESEEDSVVSEGSTISEDEVVDLQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUT8</accession>
    <name>A0A194WUT8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_594208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066086.1">
        <property type="nucleotide sequence ID" value="XM_018209789.1"/>
    </dbReference>
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        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WUT8"/>
    <dbReference type="GeneID" id="28819515"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594208"/>
    <dbReference type="InParanoid" id="A0A194WUT8"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000009">
        <property type="entry name" value="Cytosolic regulator Pianissimo, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
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    </dbReference>
    <dbReference type="SMART" id="SM01308">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="5">
        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1335" mass="149662" checksum="AC978217B3244169" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVI2"/>
    <dbReference type="GeneID" id="28828449"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722369"/>
    <dbReference type="InParanoid" id="A0A194WVI2"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="656" mass="75475" checksum="39CD72E63A412DC9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWT5</accession>
    <name>A0A194WWT5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
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        </recommendedName>
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        <name evidence="7" type="ORF">LY89DRAFT_652899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212223.1"/>
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        <property type="interactions" value="320"/>
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    <dbReference type="GeneID" id="28821949"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652899"/>
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    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
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        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
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        <property type="entry name" value="Mss4-like_sf"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SelR"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="70"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="22901" checksum="A23B3AE883BE6F37" modified="2016-10-05" version="1">MRFPTFPNIIRTFYTLSNYSRVSSQAQYKALNNFSRVTVYKSMPTFPFLSSLFSSSSSSSDMSYPVQKSDDEWQAVLSKEQFRVLREKGTEAPFVGKYDKHMPDTGIYTCAACDAPLYKASHKFKSGCGWPAYFDNIPGAVTRHTDSTLGMSRTEIVCSNCGGHLGHVFKGEGYANPTDERHCVNSVSMKFSPEDEVVDKADSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWW5</accession>
    <name>A0A194WWW5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066432.1">
        <property type="nucleotide sequence ID" value="XM_018215730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWW5"/>
    <dbReference type="GeneID" id="28825456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688554"/>
    <dbReference type="InParanoid" id="A0A194WWW5"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="142" mass="15055" checksum="3A1080F9C5724168" modified="2016-10-05" version="1">MSSTDKAAQDAKRTAISYATDWGKSPLPPTLLATLITALHARPFQPLPMLFPSVLLFSTYLNLSSYVVDSAGITAAWSGLYLLMARRRTGYMGKTFTARLGSKYGARGLTRGAAMVLAGANLVGGGVTYAFGKGGKEEDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXH0</accession>
    <name>A0A194WXH0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_653120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066980.1">
        <property type="nucleotide sequence ID" value="XM_018212233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXH0"/>
    <dbReference type="FunCoup" id="A0A194WXH0">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="GeneID" id="28821959"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653120"/>
    <dbReference type="InParanoid" id="A0A194WXH0"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF200">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="591" mass="64721" checksum="E27E49EB2E696DA9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXT4</accession>
    <name>A0A194WXT4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_193128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067141.1">
        <property type="nucleotide sequence ID" value="XM_018205721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXT4"/>
    <dbReference type="GeneID" id="28815447"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_193128"/>
    <dbReference type="InParanoid" id="A0A194WXT4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="80" mass="8974" checksum="7F3BFB8AD62EB3D5" modified="2016-10-05" version="1">MRPACMSQSRHKKKHTFFFSPCQRCNRLRACVRYRRTPPSLSACSSEAVVYLCLYSGGTGLIDHTASTSNSKITCQKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXV1</accession>
    <name>A0A194WXV1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066777.1">
        <property type="nucleotide sequence ID" value="XM_018213359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXV1"/>
    <dbReference type="GeneID" id="28823085"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673403"/>
    <dbReference type="InParanoid" id="A0A194WXV1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20838" checksum="2FFF9D19027F32AC" modified="2016-10-05" version="1">MEGRHISVIKQLYGLYWLDVWKISLQLWSEVKGMYHVLQQNLWIITLFPFFAASNWFYMYQTNDFNVPNFASRTRSFNWHWSMFFNMVGVWTMGTFLDFPFKSKHVGRATRAKTGIVYVLVVTLAMWGGGWVFVKDAVRGVSPDPLIGVPESARYFPYLAIYIFYAFYDGCFQAYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY98</accession>
    <name>A0A194WY98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_756184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067296.1">
        <property type="nucleotide sequence ID" value="XM_018221366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY98"/>
    <dbReference type="GeneID" id="28831092"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756184"/>
    <dbReference type="InParanoid" id="A0A194WY98"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="1">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="334" mass="36821" checksum="BB368CB4685A50C7" modified="2016-10-05" version="1">MLGIMSTSRIVELSCIIHEHTAKVDAYLESQKLPTPSFDTSYPAKVPLSPNIQSCQDAVLDAADELTALMLGPAAGSMSRYPHSAWASLQAIQRYGIAKTFSPTTSTTFGNIARACSLSESDTRRIVRAAMTYYIFREPSPGIVAHTAASKYLAEIPALGQLVGFLRSEMWPSAARMVGAMEKWPGSEEPNETGFALAYGTDIPMFDVVGRDPERAQRMAGAMEFMHSSPAYNVRHLLENFDWGDTPSGVLVDVGGGREQPVKWADVYYLRLVLHDWSDKYAIRILRNLIPALRKGARVLVSEICVPSPCTLSPYKERPIRNFDLSMKGVQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ71</accession>
    <name>A0A194WZ71_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_196587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067252.1">
        <property type="nucleotide sequence ID" value="XM_018205750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ71"/>
    <dbReference type="GeneID" id="28815476"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_196587"/>
    <dbReference type="InParanoid" id="A0A194WZ71"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="43912" checksum="FA7ED5A1695E89D6" modified="2016-10-05" version="1">MFQATKYAYAFHISWTELCREQTSDEDEDMSQEVWVRLKKSYGTIPGDWLTTKSYTIQAFPPRQMRPSKHFSEHVVHTHGWTLLLLTCSNSTVEVPKPVRDGFTRPWNQHERTEWAETQEFQSPILHLYARLDECLLVRSYFDNLSADVNSLLASIDCFRVLDRLRDVVPRLEHAIEEWKEWQQHHINRDSLRANPFVIATLDEIDASVQVIEKLRQDFDTMGKRAESMNTAIFNLTSVKEARESRCLNENVRLLTYATVFFLPLSFCTSMWSINDMFGSGIKGFAIVTTIFAIITYAIITYAIITYAIITYAIITYAIIAILLSPSTKKATHRLGRRMWKSTKDFVAGKTESLRKRKTKTKDQEREVVSEVMDPEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZA7</accession>
    <name>A0A194WZA7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_721333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067646.1">
        <property type="nucleotide sequence ID" value="XM_018218634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZA7"/>
    <dbReference type="STRING" id="149040.A0A194WZA7"/>
    <dbReference type="GeneID" id="28828360"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721333"/>
    <dbReference type="InParanoid" id="A0A194WZA7"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="129"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="461" mass="52180" checksum="78C2DE837779DF9E" modified="2016-10-05" version="1">MSWPNPFRRHDENTRHTWGYTFQWTPLHTTPEETNHLKFSYDELADECLQRLDAISPPTNKELPRSRSRIPAKEGSEPAPKRDLYELLRDHHSVDEKLGQLWKEVNTIPEWVDWDQIARGQDVFYRYAGVALTALAYQSLLGGMGASRITEVLARTGGFSPQVAKHRLYETTQHILQVTSSLSSIQPLGAGFASSLRVRLLHASVRRRILSLATQKPSYYSVPEYGIPINDLDCVGTIATFSSTLIWIGFPRQGIFLRAQEIEDYIALWRLVAHYMGTPTSWFSSPAQARAIMESLMIEEIRPSPTSRILANNIIVSLQNQPPAYASRDFLVASARWLNGGELADELGLVRTGWYYKALVAGQCLFFMGLCYLYRSVDYLDRKKISALRKILYQIIVHNKDHGLGSETVFEFKYIPSLDMTATEAGEYVPGVQGKRGVERRNFRMLVFACAGVGVLGQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0E0</accession>
    <name>A0A194X0E0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_558874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068015.1">
        <property type="nucleotide sequence ID" value="XM_018208429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0E0"/>
    <dbReference type="GeneID" id="28818155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_558874"/>
    <dbReference type="InParanoid" id="A0A194X0E0"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="20494" checksum="8A5BCC47A2509782" modified="2016-10-05" version="1" fragment="single">MEERDLPHFRSIPWCMSILSGPAFIITPTFSRQFKANTEDSLFATTFQTPSTISHCLSLHSHPLPDSQWIPEVRSLMTLGLGMNGGPAMLHGGVIATLMDDVIGTLLTVNKNHSTGDPLSVNTVTAYMNVKYLRPIATPQTVLVIAKSRGTLDAKRKKFLMDAEIRDGEGTVLAKADSLWIRMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0H3</accession>
    <name>A0A194X0H3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fasciclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067809.1">
        <property type="nucleotide sequence ID" value="XM_018215522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0H3"/>
    <dbReference type="STRING" id="149040.A0A194X0H3"/>
    <dbReference type="GeneID" id="28825248"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687549"/>
    <dbReference type="InParanoid" id="A0A194X0H3"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="122"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="33544" checksum="8022A840BF378DBE" modified="2016-10-05" version="1">MQPSLSAALSSASPITILAPSNDAFTKFLATAGGMSASKDSGMVAGLLEYHVLNGSFPSTAFTTEEQFVPTLLTNASFTNVTGGQVVAGMLSGKTVEIMSGLKEISKVTTADVMFTGGVIHIIDTVLTVPLPPSTSALDSSLTALAGGLEKTNLVSAVDFLKDVTIFAPSNAAFQAIGSATTALSTTQLSSILEYHVINGTVGYSTLLSTGLANETFPTLMGTEVAVEAVNKKVFVDAAMVTITDIIVANGVMHVIDNVLNPANSTATPNPAASTQAVVFAGASSVSQVPFTSGVSATTTAPSASTMTAGAERAYGTMGVAALLGMGVIAGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0P9</accession>
    <name>A0A194X0P9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Phosducin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_540309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068133.1">
        <property type="nucleotide sequence ID" value="XM_018208158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0P9"/>
    <dbReference type="FunCoup" id="A0A194X0P9">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X0P9"/>
    <dbReference type="GeneID" id="28817884"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_540309"/>
    <dbReference type="InParanoid" id="A0A194X0P9"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="71"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29112" checksum="B8FB7D7A033D7889" modified="2016-10-05" version="1" fragment="single">MAAPKEERIAVPIDDPNADTEWNDILRKHGVIPEKPPSPTPLIEEAILEGRRLAHENRLEGKDLDELDELEDLEDENFLEAYRQQRVQELASLTKKAVHGTVYPISKPDYSKEVTDASQNGPVLVNLTSGLGTNIESRVLTELWRTAAREYGEVKFCEIRGDMAIEGYPDRNCPTILVYHKGDIVKQVVTLMTMSGVRIGMPEIDKLLVEVGAVKDNDMRDIKRIRDAEERDEERKEHGGIRGAQKAKVEDEDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X173</accession>
    <name>A0A194X173_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS transporter Liz1/Seo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_754502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067967.1">
        <property type="nucleotide sequence ID" value="XM_018221331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X173"/>
    <dbReference type="GeneID" id="28831057"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754502"/>
    <dbReference type="InParanoid" id="A0A194X173"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ13612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="471" mass="52883" checksum="74129A3A40EF8F81" modified="2016-10-05" version="1">MSKQLQGVVESSAYPTSLQQPVKKDWRRFIWDSFDKSPEERHFLLKIDVALLSFGCLGFFVKFLDAANLNNAFVSGMKEDLGMFGNQLNYVTTCYTVGYIVGEIPSNIILTRVRPSIWLPVLEIIWSVLTMCLAACKNTTQLYVLRFFIGLTEAGFYPGLNYMIGSWYRKDEIAKRSGILNASGSIATIFSGALMSSVVHLGGRGGLAGWKWLFIVDGVISLPIAFASFFFLPDLPETNRGWFFKPEEIQLAQRRMVAEGRKLRTPYTVSKVKKILTSWHIWLFSILYATLGGTQGTPIFPLYLKTAKKHGKPRYNLAQINNYPSFTFTTSVVAAVAYAWISDALGGRRWPLMVFGGTVQIVLFSSLAAWNIAEGWKWACYILYGQVLGLSGITNAWANEVCRDDNEERAIVLACMNMMNNVLSAWLPLIVWQQIDAPRYHKGFITAVSTSALFVIVSGLVAVLQKRENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1F9</accession>
    <name>A0A194X1F9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_147636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068169.1">
        <property type="nucleotide sequence ID" value="XM_018205372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1F9"/>
    <dbReference type="GeneID" id="28815098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_147636"/>
    <dbReference type="InParanoid" id="A0A194X1F9"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="34817" checksum="8D86987BECBD2574" modified="2016-10-05" version="1">MMATSIETSVRSMRLYQDAGAESMSPKVKASSSFVLPDSSVLHYSLEGNLAPDSPVLLFVNDIYVNLQVWDPAIALLKESCPQYRFLRYDLRGYSVESIGDSEAITMSLLVSDLEYLFNRLSIAHIHSIVGLGFGANIALELLAKRRPIASTFVGIGFAISDSALTRRQQVVDDWPLRSSLARRFGMGILADKAVARWFTPDARRSAQWIRVREMIAAGSTEGMEKLSNAVIECAGHGTEQRGQRTLENLEVPALFLCGSSDESIPEEMETYPALMEKEKGLFILLDRTSRLACCEKPGEFVRLLGNWLHRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X246</accession>
    <name>A0A194X246_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_590791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068424.1">
        <property type="nucleotide sequence ID" value="XM_018209614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X246"/>
    <dbReference type="FunCoup" id="A0A194X246">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X246"/>
    <dbReference type="GeneID" id="28819340"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590791"/>
    <dbReference type="InParanoid" id="A0A194X246"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="26699" checksum="42EBBA7DC37E9196" modified="2016-10-05" version="1">MQSNIARPSQSGSERRSVTIIVAASQSMGMSFKRRLPWPRLQRENAYFHNTTKRVPTEGTLNAVIFGYNTWDKTPTKYYLGRINVVITKDPEEALQRLSSEYRNDFVHVATDINTAVELLERTYPYPDNGFADGHVGAETRVGTPYLGRIFVIGGAGLCREALSYSWVDRLLLTRVICDFKADTFFPLVLGGRGNEEWRRQDDQAFQNWGGDEVPIGVQFENGLEWQTFMFERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2A9</accession>
    <name>A0A194X2A9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_151413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068322.1">
        <property type="nucleotide sequence ID" value="XM_018205396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2A9"/>
    <dbReference type="GeneID" id="28815122"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_151413"/>
    <dbReference type="InParanoid" id="A0A194X2A9"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF15">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="29389" checksum="ED5EF427EB9D7BB3" modified="2016-10-05" version="1">MAFPYKHVVLIGATSGVGKGMAESLVESGVKVTAVGRRQDRLNEFVNKYGKDKADGAVFDIAEYQKAQQFAADIMEKSRDIDCLFLNAGIQRNWDLAELENIDLEEFNSEMTINYTSFVALVQAFLPYLKNQKPASIIFTGSNIAIVPASTLPNYSASKTALNVFTLCLREQLKVAGSHVKVIEISGPPVQTELHDYMGAETGRKMGMPLEDFTKLVMDGFYAGHDQIVIGSILDPTTFNEIVNKRRTAFEKLAEIIRVATKTHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2Y1</accession>
    <name>A0A194X2Y1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">7-dehydrocholesterol reductase</fullName>
            <ecNumber evidence="18">1.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Sterol Delta(7)-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">LY89DRAFT_698617</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17737"/>
            <dbReference type="ChEBI" id="CHEBI:27910"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:46741"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>cholesterol + NADP(+) = 7-dehydrocholesterol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:23986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.21" evidence="18"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068547.1">
        <property type="nucleotide sequence ID" value="XM_018216996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2Y1"/>
    <dbReference type="STRING" id="149040.A0A194X2Y1"/>
    <dbReference type="GeneID" id="28826722"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698617"/>
    <dbReference type="InParanoid" id="A0A194X2Y1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047598">
        <property type="term" value="F:7-dehydrocholesterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000004">
        <property type="entry name" value="7-dehydrocholesterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF38">
        <property type="entry name" value="7-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 23" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16 23" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KUJ14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="388" mass="44503" checksum="72DC6664EA557B33" modified="2016-10-05" version="1">MLQFGPATFYSTFAPKPDLNVALGYSAWILFQAALYRFLPSKFSTGQLTPAGNLLKYRTNGLSAWIVTHSLFAIAALTGIVNPAILARHWAGLLVVANVSGFLLTGFVYIKAHLSPTHESDRKFSGSILYDMYMGIELNPRFGEYFDFKLFTNGRPGIVAWTLIDWSFIAYQYQLHGYITYSILVATALHTLYVVDFFINEDWYLRTIDICHDHFGFYLAWGSLVWLPGIYTLQTQYLARYPGTLSDFHALVILMTGVTGYVIFRSVNHQKDLVRRTKGNCKLWGAPAQVIRVKYRTKDGLEHNSILLCSGWWGLARHINYLGDLILSYSMCATCGFKNLLPWTYAIFMTILLIHRCWRDEERCSKKYGKGWEQYCKRVKWVIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X371</accession>
    <name>A0A194X371_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_619700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069005.1">
        <property type="nucleotide sequence ID" value="XM_018210891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X371"/>
    <dbReference type="STRING" id="149040.A0A194X371"/>
    <dbReference type="GeneID" id="28820617"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_619700"/>
    <dbReference type="InParanoid" id="A0A194X371"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="804" mass="92232" checksum="AEAD7B8E0B558FCA" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3M4</accession>
    <name>A0A194X3M4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_649331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069150.1">
        <property type="nucleotide sequence ID" value="XM_018212053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3M4"/>
    <dbReference type="STRING" id="149040.A0A194X3M4"/>
    <dbReference type="GeneID" id="28821779"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649331"/>
    <dbReference type="InParanoid" id="A0A194X3M4"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13696" checksum="4CB6EF208DA80744" modified="2016-10-05" version="1">MPQDLPPVGGYEPVQYKRNLPARGFRPSVMLLGVAGIMTFGFYKIGKGIREQNELAREKMWSRIHLIPLLTAEEDRDLVRRHLADQKREEELLGSRTSPYHSDRFVRPTYAVTPSQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4A7</accession>
    <name>A0A194X4A7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_784042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069361.1">
        <property type="nucleotide sequence ID" value="XM_018222747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4A7"/>
    <dbReference type="GeneID" id="28832473"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784042"/>
    <dbReference type="InParanoid" id="A0A194X4A7"/>
    <dbReference type="OrthoDB" id="3068835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="45680" checksum="B177BA5F7EAD1DD8" modified="2016-10-05" version="1">MPSNWPTVSEKDQSTTSEIYEASEVNYEDRRETLPPQYSEYSMPMNSDLQKPVVIPQQTNIFMIKTFSPFARAYSPAFSTLPNPIPKDEFISFIDGLNKAFISSPIFQAAHVVGGGLLGSQILPAQAVGGVFQVVSVLGSAGVSVIRVRRYMKKANANIFAPRGLIVKIMSTKKMMTEVGCPTVDPKGKLALPPLEELSDLTPQTGALIRHPTGGTIHSRTGSSVEDPRMRRIRALGNYISPLEFETTLAQPKGMMDKYGGAPLRWMNKRADTKLVKAADKSASARLEKAPEAEVILNSAERKLESISSRMAEIHDTSLRERNRYPEDREKIEAVAERELASLEEKRNGVVEERDRKIKAIYEKGDKKLEKLAKKEEKIANRILWVVVQRLDGHVGDELLEVESRGSSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5V4</accession>
    <name>A0A194X5V4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_783691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069915.1">
        <property type="nucleotide sequence ID" value="XM_018222710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5V4"/>
    <dbReference type="GeneID" id="28832436"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783691"/>
    <dbReference type="InParanoid" id="A0A194X5V4"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24069" checksum="3077354D9FDB616E" modified="2016-10-05" version="1">MEKKSGEKRKALLLEADPTMYPHQCDIRFTEEFVNTPEQRRSLQSGVWDQNDPDLTQGRARRPYRNICLLPYLNIESLKNDPARLLNIIYNRVKYSPKQWWGFDNYLLDKQWKIGSLSTPYNRSGLVTYGSRYGDLVPWQERSAHAHDIIGFPRGILVLEAQMKLSETLKAIVEKLVEGVEAANDTGTFSQALETGLKKVSDQSSCVEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X650</accession>
    <name>A0A194X650_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_750611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069642.1">
        <property type="nucleotide sequence ID" value="XM_018221209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X650"/>
    <dbReference type="FunCoup" id="A0A194X650">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X650"/>
    <dbReference type="GeneID" id="28830935"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_750611"/>
    <dbReference type="InParanoid" id="A0A194X650"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="730" mass="81179" checksum="A828A1FA80F61BD7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X816</accession>
    <name>A0A194X816_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_685320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070660.1">
        <property type="nucleotide sequence ID" value="XM_018215059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X816"/>
    <dbReference type="FunCoup" id="A0A194X816">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X816"/>
    <dbReference type="GeneID" id="28824785"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685320"/>
    <dbReference type="InParanoid" id="A0A194X816"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="42492" checksum="43D19B37205B39F4" modified="2016-10-05" version="1">MAFKITKMPLIQGPKLSSSKLFSYARSFSTSEILRARIRDTMIPNTSIRVFREIPALRQWRRKQLLDYRSVGLVPTMGALHEGHLSLIRIAAKENSSVVVSIYVNPTQFGVHEDLDSYPKTWEKDVEMLKDLDRELAADGGNLGKIAAVFAPTTNEMYPSGRPSQEIDGKGSFITITPVGEVLEGASRPTFFRGVATVCMKLFNIVTPEKVYFGQKDVQQTVVIKKMVKDFCLDTQVVVGNTKREPDGLALSSRNVYLGARRRNVATILSKVLRTAQTGYLRGKRSREELLGPANELAKLLLKEQFQLKPEERVQFEMDYVSLADPETMQEVDEVDEARGAILSGAVKMLPVESPQPGEDLGLAGGPPVRLIDNIILKPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X877</accession>
    <name>A0A194X877_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_782637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070728.1">
        <property type="nucleotide sequence ID" value="XM_018222600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X877"/>
    <dbReference type="GeneID" id="28832326"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782637"/>
    <dbReference type="InParanoid" id="A0A194X877"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19448" checksum="DFC52E70A38785C1" modified="2016-10-05" version="1">MLERMMIFLINIFLPPLSVMILAGVGPDCLINTLLFICGVIPAHIHGFYISCTYYSRKRKVRKGRFPGGRKSFIYSQQVINGGASDERVRELWKAKCRAEEGGNGRKKSGGREERTRSGRGSDSGGSGEERTWDGRRESRRVCTRNSTAGSRASSVRYNNHGQPMTEVKGWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9B3</accession>
    <name>A0A194X9B3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_747893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071113.1">
        <property type="nucleotide sequence ID" value="XM_018221142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9B3"/>
    <dbReference type="FunCoup" id="A0A194X9B3">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="GeneID" id="28830868"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_747893"/>
    <dbReference type="InParanoid" id="A0A194X9B3"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF32">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267997" evidence="1">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="365" mass="40170" checksum="6F7DDBDF85922686" modified="2016-10-05" version="1">MYHIAFLGTIFAIFCATQAHQLKQKPLAQYISYSSVPGYFLQDNNSTNSSTFDFVATNFGLINQTYPTDAQFDPKNTKSQWERFANQVFRLNLVSPSNIEYKILFIGRHGEGYHNAAETFYGTPAWNCYWAQLDGNSTVTWFDAHLDANGVAQAQTVNNLWSRLIATQNIQTPQSYYVSPLTRCLQTANVSFSGLDLPASHPFVPEVKELLREGIDIHTCDSRSNLTYIKSLFPSYTIEPGFTEYDLLFRQSTSETPTAQGLRSKTLLDQIFSTDGETFISFTTHSGEASSLLSVLGHRSFSLSTGAVIPILVKAETLSGTAPVTTVLPYTSQVVCNAPPITSQATGTCVCSSGSTISTGLAKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAR1</accession>
    <name>A0A194XAR1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_684880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071202.1">
        <property type="nucleotide sequence ID" value="XM_018214979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAR1"/>
    <dbReference type="FunCoup" id="A0A194XAR1">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="GeneID" id="28824705"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684880"/>
    <dbReference type="InParanoid" id="A0A194XAR1"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ16847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="80" mass="8973" checksum="B549D1B3B150114F" modified="2016-10-05" version="1">MANGWSILIGFVVVALACAAGWFLSPKGETQTIWRSSLILSFASCYLMWVITFLAQWHPLIEPRASGLRSHAVYENYRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB49</accession>
    <name>A0A194XB49_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_733253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071755.1">
        <property type="nucleotide sequence ID" value="XM_018219780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB49"/>
    <dbReference type="GeneID" id="28829506"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733253"/>
    <dbReference type="InParanoid" id="A0A194XB49"/>
    <dbReference type="OrthoDB" id="4378459at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268021" evidence="1">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="138" mass="14950" checksum="79B41190B1607BF5" modified="2016-10-05" version="1">MNLGMFAQLAALLALSPVIIGTPSYLRSPGVNVPTVIPTPENPDMTPILQALQAQGLNATFGRVRTSDASSTIENTERRSHSLEKRVIPTCITFGSTPYQDDCNYAKKLVINTAMNYDLAPYGCQRSRTIGSENDNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB63</accession>
    <name>A0A194XB63_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_684462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071766.1">
        <property type="nucleotide sequence ID" value="XM_018214887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB63"/>
    <dbReference type="STRING" id="149040.A0A194XB63"/>
    <dbReference type="GeneID" id="28824613"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684462"/>
    <dbReference type="InParanoid" id="A0A194XB63"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="302" mass="33794" checksum="A32CD25C72C0D3FE" modified="2016-10-05" version="1">MSSDEKEPLINKNQSLQDYYASLESRIGYRFVLGGTRHFGFYTRGTYWPFPIGKALRAMEDNLIGTLDLEKGSKVLDAGCGAGYVAIHLAEEGYRVHGIDVVDHHIVKARRNVKTQGLEGTITVTKGDYHHLDAFADDSFDGAYTMETFVHATEPEAAAAEFFRVIRPGGSIAMYEYDHLDFSTQPEEVGDSWTAINKHAAMPAYDRFQQGVLKGILEEVGFEDVEVKDLSDNVLPMLRLFYILAFIPYLIIAFLGLKSYFINTVAGYEGYVYRDAARYISVSGKKPLAAGEVEPSEEKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD98</accession>
    <name>A0A194XD98_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_60414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072082.1">
        <property type="nucleotide sequence ID" value="XM_018210343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD98"/>
    <dbReference type="GeneID" id="28820069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_60414"/>
    <dbReference type="InParanoid" id="A0A194XD98"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="59"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="255"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64611" checksum="BE0C5FC3C9062F19" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDC5</accession>
    <name>A0A194XDC5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_781266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072535.1">
        <property type="nucleotide sequence ID" value="XM_018222468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDC5"/>
    <dbReference type="STRING" id="149040.A0A194XDC5"/>
    <dbReference type="GeneID" id="28832194"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781266"/>
    <dbReference type="InParanoid" id="A0A194XDC5"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443886" description="Pectinesterase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="32"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ18180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="34297" checksum="5604B489D1D4A77F" modified="2016-10-05" version="1">MHLFFYISAFATAVLATSRTTAPSGAITVGSGGTYSTIQDAIDSLSTTSTTAQSLFILAGTYTEQVTIPSRAAALTIYGYTTNTASYTSNVVNIEHSSSLASGASSDEATGTVINEAANTKFYNINIKNTYGEGSQAIALAAYNTEQGYYGVGLYGYQDTLLAETGNQVYAACYIEGAVDFIFGQHAIAWIDSSDIRVSAGGGAITANGRSSSSDVSYYVINKSSVDTTTSSTATSGTVFLGRPWSEYARVCFQDTVLSNIINSAGWEEWSSSEPNTEDVTFEEYGNTGDGASGTRASFSTKLSSALSISTILGSGYADWVDTSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDP6</accession>
    <name>A0A194XDP6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1751-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_781346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072626.1">
        <property type="nucleotide sequence ID" value="XM_018222477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDP6"/>
    <dbReference type="FunCoup" id="A0A194XDP6">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDP6"/>
    <dbReference type="GeneID" id="28832203"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781346"/>
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    </dbReference>
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        <property type="entry name" value="DUF1751"/>
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            <end position="27"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18271.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="38721" checksum="702BC0F2E59AB0D9" modified="2016-10-05" version="1">MPPRLNIPPITRILLIALVSQSLLSFAIRYRQWSEESDIVVPYIALVPQLSLIYPWTFLTTTLVENNVFTLGISGVTIFYGGRYLERAWTSTEFAKFLLITALTPNALCFGTLVILFAATGDMSWTLTTINGTVPLQISFLVAFSQLVPAHTVTLFRGIVSLRVPRFPLLHILGVSLLSLTPLLSVASFLLATSGFLTSWIYLRFYKPAFPDLDTAQSSLRGDASETFAFAEFFPDPVKPFVSSFSDQVYNVLVSLRICSPFSAADVSASRGDTFMQRGTPGSARAEAERRRALALKALDQRLHAATAGSSKSQPPPPATGPSVQVQPQPNVQTPQAMLGETTYVPEREGEGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDR5</accession>
    <name>A0A194XDR5_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="180" mass="18738" checksum="624F1CE709CC2C3A" modified="2016-10-05" version="1">MLEASEASEDVMLEATEANEEVTDGASDVTDEAWDSIEESAEETTDSIEDKAEVGAADSLDSMEGRTVMGDTTGVLLNDSVGIPSEGPTAAVPVERAAGVVRAEIEGTSVVEAVTMTVVRMGRTAEYESRASAITAAARCSKPDSMAETPVAVAVMAAYSLERLDSRAAKLICAFVYMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDZ1</accession>
    <name>A0A194XDZ1_MOLSC</name>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="595" mass="67978" checksum="436401832D52AB60" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE05</accession>
    <name>A0A194XE05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_47190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072736.1">
        <property type="nucleotide sequence ID" value="XM_018207769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE05"/>
    <dbReference type="GeneID" id="28817495"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_47190"/>
    <dbReference type="InParanoid" id="A0A194XE05"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18381.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="60586" checksum="CDDD23AA33F787D5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE99</accession>
    <name>A0A194XE99_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_732780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_732780"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="MBOAT_2"/>
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    </dbReference>
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            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="49549" checksum="CFDDB7AF966CE94F" modified="2016-10-05" version="1">MDSTAFWVWVDAFRRLLQVPLCLFIALMFPKIFYSSFLARILTLAFIAFEAALVFRPHEITNMIILYLTGFGAILFLIWSAIMLLFCNPLQDFRRLRRVAVTRIDAKPAVKYEWEAYPTELGWERASWVLDLLVNLRGVGWNYQKPRYLVPQDVQKLYQDIGIDVSSFKPTRGNTLDISTFYKTQSMLLVTRYLLVDLCINLMDINPFFQGSEPPLNWIFPLSPRNLLLAPYNAFLAAIGVYAVLDLYGTCVALIQASLLGPNILGTWGEPFMYPRLWGPLSAIWDEGIIGFWSTMWHDVFKHAFLTLSRALIPGSTRTSKFLRLNTIFVLSALCHAAASYMQAAHTYPILTSISFASQGLAISLQSLIVSFLEKRGVSEVTRKTIVLVFAVVWAYFSMYMFLGDLAASRAFTLKLVPVSVFGLVMGRRWPGWLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEA5</accession>
    <name>A0A194XEA5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEA5"/>
    <dbReference type="GeneID" id="28818868"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582089"/>
    <dbReference type="InParanoid" id="A0A194XEA5"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
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            <end position="438"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74809" checksum="7646F5B7159994E4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEM7</accession>
    <name>A0A194XEM7_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28818030"/>
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    <dbReference type="InParanoid" id="A0A194XEM7"/>
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    </dbReference>
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        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="12489" checksum="86CD29F86363041B" modified="2016-10-05" version="1" fragment="single">MCYYDQYQMTCGDWKWGNFRKQCSKEYRTGDTCGMKLIMEAYQLDEMCKYCKKVEIKSAKIRKEQDRIKRWCNEGNRRASIEAAEENIAAIEREIMDLMDQTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEM9</accession>
    <name>A0A194XEM9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_667722</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073000.1">
        <property type="nucleotide sequence ID" value="XM_018212996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEM9"/>
    <dbReference type="GeneID" id="28822722"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667722"/>
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    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20800" checksum="AE10CFA091A23953" modified="2016-10-05" version="1">MSFTDLEDVEIQQESTRRALISSRPFWLTMSRVLQLLLAFTNLILTGYAVSIFGGDFFHTFGISFLAFVWTVVFMLYIFITPERAPKLYFYRVHIILEIITTAFWIVTLALLAWECQTWDAAEDVVNDSLTEAEAALVNSLPNQWSGVTAFRVALAFATMETILFSTTMFIIRRLLIQSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XET5</accession>
    <name>A0A194XET5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_667737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073016.1">
        <property type="nucleotide sequence ID" value="XM_018212997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XET5"/>
    <dbReference type="GeneID" id="28822723"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667737"/>
    <dbReference type="InParanoid" id="A0A194XET5"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="398" mass="43960" checksum="4B792FD8F1FC21DD" modified="2016-10-05" version="1">MFSLSSDESFHFELLRALALSRYHGTDINEVLVAASKITPGDFESFSSVFTALASRTLDRAISLDSKKYQVSARDAFFAASSYFRSADFYLHGNKSDPRIDELWKKQTFAFDQAIRLLPTPGERKLLKADGFDVPLIFYAAEGAGRKPTLILGNGFDGAQEEMLHSCGFAALERGWNVCTYEGPGQCTVVRDQGLGFINEWEKVVSPVVDYLETREDVDVKKVGLVGFSMAGYLCVRAAAFEHRFAAVMAVDGVYDVGEAFTKMAGPLVKVADEGGDVDSTAREWLKDPGVPSTVKWGVGHGLWSFQTDSAMDFLERTKKMTLKGIESKVQCPIWVGLAKDDIFFGGQPEKMKEVFGDQATLTELTAEDGAGEHCHVGAFAFMNQKVMDWFQDVIERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG58</accession>
    <name>A0A194XG58_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_613847</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073112.1">
        <property type="nucleotide sequence ID" value="XM_018210672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG58"/>
    <dbReference type="FunCoup" id="A0A194XG58">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XG58"/>
    <dbReference type="GeneID" id="28820398"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613847"/>
    <dbReference type="InParanoid" id="A0A194XG58"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ18757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="50958" checksum="C1E3D07481F56D04" modified="2016-10-05" version="1">MSKFFSSPFLVFSSAIALRIGLFFYGLWQDANSPMKYTDIDYYVFTDAARFTAHGHSPYDRETYRYTPLLAWMLLPTTWSSTWFSFGKVLFAVGDIVAGWLIIMVLRSSNKMSMERALKFASIWLLNPMVATISTRGSSEGLLGVIVVALLWAITQKKIVLAGFLLGFGVHFKIYPFIYAPSIIWWLDDEQLGRSKPAKEGEGSDLVSLVKNFINGPRITLTISSLLTFLSLNTLMYIIYDYPFLQHTYLHHVTRIDHRHNFSPYNTLLYLSSSIPDPSPTAIKLESLAFIPQLFLSAVALPILLAKKDLASTMLAQTFAFVAFNKVCTSQYFLWYTIFLPFYLPTSTLLSRPYLGLSAAGLWILTQALWLQQGYQLEFLGNSTFVPGLWVSSLLFFGVNVWILGIICSDIEAGTAPVITKPEQRPLRKKKEVKVKAKGKGKVSVLDIGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGI5</accession>
    <name>A0A194XGI5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_487296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073606.1">
        <property type="nucleotide sequence ID" value="XM_018207860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGI5"/>
    <dbReference type="GeneID" id="28817586"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_487296"/>
    <dbReference type="InParanoid" id="A0A194XGI5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="71" mass="8145" checksum="F0B4498B13BC9FF1" modified="2016-10-05" version="1">MAEDVPYTVLSWGFCMLVARLIGILQIFNSNKAIVKVMKTLDVRRSCQRIVFFINSETVQRTPKIPLIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGI9</accession>
    <name>A0A194XGI9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_581246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073638.1">
        <property type="nucleotide sequence ID" value="XM_018209105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGI9"/>
    <dbReference type="GeneID" id="28818831"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581246"/>
    <dbReference type="InParanoid" id="A0A194XGI9"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="30404" checksum="8CB9C4852A99F352" modified="2016-10-05" version="1">MAAVEKRIDLGPDDKEIERLTAQHKIMKSCYEKLILAPIDLSKPGLRILDSGCADGLWLREVQPLIASPHSLIGTDFNPNLFPSDPPGQIMHQAQDITKPWPADWANSFDFVHQRLVLGGCGPFGPEKAVKHMIELVKPGGWIQLDEMDLAGEQQLPGMGGELGRIIRAVFEASGGQWDFATKMKQWMIEAGLENVEEKTIHVAFGKSNPDPEIAKLGIWSLTTSTKALCFAGKTEMGIKGFTEAELDSMGERCEKELIETGVDSPMLSVWGRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGK6</accession>
    <name>A0A194XGK6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_683209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073685.1">
        <property type="nucleotide sequence ID" value="XM_018214660.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XGK6"/>
    <dbReference type="GeneID" id="28824386"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683209"/>
    <dbReference type="InParanoid" id="A0A194XGK6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="519" mass="58966" checksum="4063098E0FCF264A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH18</accession>
    <name>A0A194XH18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_667072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073422.1">
        <property type="nucleotide sequence ID" value="XM_018212952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH18"/>
    <dbReference type="GeneID" id="28822678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667072"/>
    <dbReference type="InParanoid" id="A0A194XH18"/>
    <dbReference type="OrthoDB" id="3594971at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="559" mass="64754" checksum="80C898C6EE6EB015" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH47</accession>
    <name>A0A194XH47_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_642559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073843.1">
        <property type="nucleotide sequence ID" value="XM_018211757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH47"/>
    <dbReference type="GeneID" id="28821483"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642559"/>
    <dbReference type="InParanoid" id="A0A194XH47"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF3">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="81"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="357" mass="40950" checksum="555B5B81CF52ED24" modified="2016-10-05" version="1">MHQNPCPLDAQERREVAEISGAGDVTQVLERQWRIPTPLRRMLQGLSGLCTYVKSPFVTKPPAQPRRKIDVRTLNQCPEGYPRLAAFLDADENFMLYRRFGFLQARVLLYKQDELRELERELDRIDCIDQHSNDKSVLKSREKDDKVTNTRKNMIGKIETKLKEYSEMLLISRDLVALNRPPHRDYTSVKSYFDEEAPLCDVESYIYSREDIVALKPGRESAWLDSFIEGLLQRFACRLIRCIFRTSDLQKKTNPEETNIILYSRDRIGIVVSLIILVTILALLITPVYLLWHFTSGPETASTTAVMITIFGCFTLLFSLTLSKFTSAKRQEILAAAAAYCAVLVVFVGNVKQNRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHK8</accession>
    <name>A0A194XHK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_579834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
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            <dbReference type="EMBL" id="KUJ19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIN7</accession>
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        <submittedName>
            <fullName evidence="10">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_779864</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
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            <name>heme</name>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="474"/>
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        </ligand>
        <ligandPart>
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        </ligandPart>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="534" mass="60673" checksum="05E45E2F055F5FFB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ10</accession>
    <name>A0A194XJ10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_639563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ10"/>
    <dbReference type="STRING" id="149040.A0A194XJ10"/>
    <dbReference type="GeneID" id="28821355"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639563"/>
    <dbReference type="InParanoid" id="A0A194XJ10"/>
    <dbReference type="OrthoDB" id="5243398at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="930" mass="98451" checksum="74D88DDE02D462FC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKG3</accession>
    <name>A0A194XKG3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Soluble quino protein glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_640356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074986.1">
        <property type="nucleotide sequence ID" value="XM_018211663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKG3"/>
    <dbReference type="GeneID" id="28821389"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_640356"/>
    <dbReference type="InParanoid" id="A0A194XKG3"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268417" evidence="1">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="467" mass="49597" checksum="6F0BC1C2F22FDFC9" modified="2016-10-05" version="1">MKLFINIVLGAILSEIVSAITCNLKPTYPTPSTSDGWQAQLVANELTSPRSILFDGSGNLLVVQSGAGIVHLAFDDGGSTCLDVSKKTFLVNSTELNHGIALSNDGKTLYASSSEAVYSWSYDASAISVSTTNQTLVTGMTNDDHTTRTLLMSQKSPGTLLISRGSTSNIDPEAALLSSGHSQIKAFNTSNLTKTSTPYDFNTQGLLLGWGLRNSVGVAEEPLTGGIYSVENSADEIDRDGVDIHENNPGEEMNFHGFLNGSTQDQGGNYGYPACFALWNTSIPDLGSLVVGDQFTLQQNATFNDSTCNEERVAPRLTFQAHMAPLDIVFLENGTEAYISFHGSWDRTNPIGYKVSSVSFSTGEPTAAKDSTNSTVDIFANKDNSQCPDGCFRPVGLAVDGKGRLWVSSDATGELYVLARTSTATATSSGASPSATKKGMGMKVEMGDRGLWVVVLLMSLGFGLGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKR7</accession>
    <name>A0A194XKR7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_730841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075180.1">
        <property type="nucleotide sequence ID" value="XM_018219518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKR7"/>
    <dbReference type="GeneID" id="28829244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730841"/>
    <dbReference type="InParanoid" id="A0A194XKR7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268354" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="14707" checksum="5BCEDB8CC51258ED" modified="2016-10-05" version="1">MFSSSIIAALTVLSTLSMAAPTPACHDCLGPSGPQSLVNPVVNIEVVTSLGLDPNKTSYLVPTSINVPTPCYASDGVSRCTTSELILSTVANTTDTTYIECRVYEDFKATIGGTVFNQSMPVQISTNTDFVGSWLCYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLH0</accession>
    <name>A0A194XLH0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_578725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074977.1">
        <property type="nucleotide sequence ID" value="XM_018208963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLH0"/>
    <dbReference type="GeneID" id="28818689"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578725"/>
    <dbReference type="InParanoid" id="A0A194XLH0"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000596">
        <property type="entry name" value="Vitamin b6 transporter bsu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF36">
        <property type="entry name" value="MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="507" mass="55745" checksum="43196FA878821CAE" modified="2016-10-05" version="1">MDPAVAEQDKEKQLHQDSPPPGPEFEKGHVAPEGPQNPGQDPDTTLAILELVQAKDVHHPMHWPAWKRWGIIILYCSLQMFVTITSTSYIGAEYDINLKWGGSTQVITLGQSLFIVGNAVGPAFMGPLSDIGGRKWVYVASITCYAILNFGTAYARNLPMLIIFMFLAGTAGSTALSNVAGTIADLFGDIDGAGQAMALFVVSANVGPSIGSPIGGWITANESLGLKWIFLINVIIGFGYAVIMCFMPETLPRLVIARAAAKAQEVDSDEEAILRSKVNVWKELRFVTTMTFRIMFTEPIVLALGIYNGFAYGILFLYLDGVYDVFAINNGLSIISADLTYLNFVVGVLVMFCFIPVQTYFFTRDRVKHGHPRPEARFLVSLVTVWLFPITLLWFAFTSSGNVSYWSPIVAGGVLGFADPLLWLSMLNYITDSYPNVAASAIAAFLIPSFVMAAALAHLGVLMFENMSTKWAMATIGFISFGLCALIYFIFFFGEKIRRKSRLARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPJ2</accession>
    <name>A0A194XPJ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_380069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076012.1">
        <property type="nucleotide sequence ID" value="XM_018207124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPJ2"/>
    <dbReference type="GeneID" id="28816850"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_380069"/>
    <dbReference type="InParanoid" id="A0A194XPJ2"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF33">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="30742" checksum="FF17775E740B472F" modified="2016-10-05" version="1">MTEGNLYQYNPNSAIAAVAAVLFGISSCFHLFQMIQKRTWFYLAMTIGGFMMTAGYVFRVLSIHSPHSLLLYILQAVLLLLPPSLYAATIYMIYGRTVLFVNAPDASIIRPTWVTKIFVIGDVFSFLVQAYGGSMEAQASKAKTGSHIVLIGLASQLIFFGFFLVVAIIFDRRMSKSPLRYTVPTYGKHNWRSLLLLLLGAAVFIIVRCLYRVAEFAPGNGGYLMSHEWPMYVGDTLPMLVVQVVFHIIHAGDVFPRGQTQKSEEESYINLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPS1</accession>
    <name>A0A194XPS1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_638216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076409.1">
        <property type="nucleotide sequence ID" value="XM_018211562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPS1"/>
    <dbReference type="GeneID" id="28821288"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_638216"/>
    <dbReference type="InParanoid" id="A0A194XPS1"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23369" checksum="355808ECBC8CE9C7" modified="2016-10-05" version="1">MSFLNSSTEVKTTTILKPHITRSHVLRLLHNPSKMLALNPIIKSHSPLPDSSSKAFFTRVAPENKPPTTGPEQIVPVYAIVESTDAESSEGGGSWRGGWAKRFIPESITYETSMQNTEEGMISITQAPMGVQSVTRWTVTEKPGEGLVLEKRGKVTSNRMLMTFIKTTIQGSYEKLANDFVIELERMIDEEEQEKKKESEEEVVVEKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQI7</accession>
    <name>A0A194XQI7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_293527</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076679.1">
        <property type="nucleotide sequence ID" value="XM_018206531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQI7"/>
    <dbReference type="FunCoup" id="A0A194XQI7">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQI7"/>
    <dbReference type="GeneID" id="28816257"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_293527"/>
    <dbReference type="InParanoid" id="A0A194XQI7"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ22324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="145" mass="14960" checksum="17B3906DB4B6B219" modified="2016-10-05" version="1">MANKQGKMAGLINYRMRVTMNDGRQMVGQMLAFDKHMNLVLADTEEFRRVKRKANKTASAPGAASSSAPLVESEEKRTLGLTIVRGAHIISLSVESPPPADPSARLGASAPGGVATTLAAGAGIARPAGRGIPVGLAVSLTAVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR59</accession>
    <name>A0A194XR59_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_302918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076894.1">
        <property type="nucleotide sequence ID" value="XM_018206582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR59"/>
    <dbReference type="GeneID" id="28816308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_302918"/>
    <dbReference type="InParanoid" id="A0A194XR59"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="366" mass="39627" checksum="49074331938D55E8" modified="2016-10-05" version="1">MPVDRGPELASVLGLFLGLATLFVCLRLYVKTFLSKSWGIDDALLIVALIFFATYCSCSATGVHYGTGQHITDIPLEHIPKALYYWWLCELFYTVTTVFIRLSIAVFLLRICVKPIHKYIVYGTLSMVIVFSTFYFFLVLFQCSPYSYFWGQYEGKKGSCINPAAVPDASITHSVVSFTADWILGLLPIVLIYDLKMNVRTKVSVAGLLGLGLLAGIAAMIRIPFIKTLALTDDFLFATTDVAIWSTVEPGLGLMAVGGATLRPLFRSFYNLSTRGGNTLPRSGYMKNPDTPIQLRNDVGGKGTVTSIRSPFGDSSEAVGGSGGGGGPMGINVQKSVVVSRAESEASSLSGDAMPWGELKGRGDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR98</accession>
    <name>A0A194XR98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_693690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076607.1">
        <property type="nucleotide sequence ID" value="XM_018216652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR98"/>
    <dbReference type="FunCoup" id="A0A194XR98">
        <property type="interactions" value="1237"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XR98"/>
    <dbReference type="GeneID" id="28826378"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693690"/>
    <dbReference type="InParanoid" id="A0A194XR98"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140454">
        <property type="term" value="P:protein aggregate center assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="418" mass="45713" checksum="6E2218CCF8B5F45C" modified="2016-10-05" version="1">MPKDNKFYEILGVSPTCTEAELKKAYKVGALKYHPDKNAHNPEAENKFKDLSHAYEILSDPQKRSIYDQYGEEGLEGGAGAGGMNAEDLFSQFFGGGSAFGGGGLGGMFGGGMPQRGPPKARTIHHVHKVSLEDIYRGKISKLALQKSVICPKCDGRGGKEGAVKKCAGCDGHGMKTMMRQMGPMIQRFQTVCPDCNGEGEIIREKDKCKGCNGKKTTIERKVLHVHVDRGVRTGHKIEFRGEGDQTPGVQPGDVIFEIEQKPHPRFQRKDDDLFYHAEIDLVTALAGGTIFIEHLDDRWLSVEILPGEVIAPGSLKMIRGQGMPSFRHHDFGNLFVQFDVKFPEKNFTTDPAAFEALKAIIPHTKSPITPPAETMTEIVDFEDVDASQQARAAGATAMDEDDEDGHAGGERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRR3</accession>
    <name>A0A194XRR3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo-keto reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_679810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077335.1">
        <property type="nucleotide sequence ID" value="XM_018213941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRR3"/>
    <dbReference type="GeneID" id="28823667"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679810"/>
    <dbReference type="InParanoid" id="A0A194XRR3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32762" checksum="AEB53D2678B2E27A" modified="2016-10-05" version="1">MAPITINSTVRMNSGFEIPLLGYGVYQTPADVCEDVTKLSFQAGYRHVDSAAAYRNEAPCGKAIRESGIPREKIFFTSKIPARSLSYENTKAQVEKTLKETGLDYIDLMLIHAPYGGRNARKGAWKGLVEAVEEGKIRSIGISNYGVQHLDEMEEYIQELEKERGGKGKGGVISVGQYELHPWLPRPDIVQWLQKREVVVEAYSPLVRGERMEEKVFEPLTKKHGKTAAQILMRWSLQKGFVPLPKSVTPSRIVENADVYDFELTPEEMKTLETTEYAPVCWDPTVAPLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS06</accession>
    <name>A0A194XS06_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_663554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077435.1">
        <property type="nucleotide sequence ID" value="XM_018212711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS06"/>
    <dbReference type="GeneID" id="28822437"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663554"/>
    <dbReference type="InParanoid" id="A0A194XS06"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="258" mass="28310" checksum="839F15AF19ACB1E5" modified="2016-10-05" version="1">MLSHKLNCKFPPQVSTGEPTLLPAQVTVHAAVPTKELEDVIKVDKTTDFVDDDEDPIIITDEEYDKGLIEDVETTSLTEDDEDGIRVDETLGLIEDDENPSSDTEGEDGIKVDETTGKFEEDEAPTVIKVDVRTGSIEEDEVPGLIENAEDVIEVDGTISMLEDEDPTTVAAGEDWIEADDTTGFALEDKDGVGLGMTREDEDEDNNREDVWMTKDEEDIDRYGKLVETTNTNDDEDRYGVSGSVVDETGDGVGPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSA5</accession>
    <name>A0A194XSA5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_704279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076967.1">
        <property type="nucleotide sequence ID" value="XM_018217369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSA5"/>
    <dbReference type="GeneID" id="28827095"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704279"/>
    <dbReference type="InParanoid" id="A0A194XSA5"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="307"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1140" mass="124871" checksum="31C33412F0D499C1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSP8</accession>
    <name>A0A194XSP8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_713602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077419.1">
        <property type="nucleotide sequence ID" value="XM_018218064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSP8"/>
    <dbReference type="STRING" id="149040.A0A194XSP8"/>
    <dbReference type="GeneID" id="28827790"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713602"/>
    <dbReference type="InParanoid" id="A0A194XSP8"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
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        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="79"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="301"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="499" mass="54194" checksum="781C48EECA40B9F8" modified="2016-10-05" version="1">MVSAVRIAPTRAVRAMNLLRTVQYTHPPTCPCHGNPNHHHHHKPSNGLLAHAKRNLQRNYATPVDLSRQKEYAFEMAASSIRFGPGVTKEVGMDFKNMGAKRVCVVTDSTVRNLDAMKQVIEGLTREGVEFTIYDGCRVEPKDSSIKHAIDFAKPYQPDAFLAVGGGSVIDTAKLMNLYTCYPNAEFLDFVNAPLGKGLPIDKPLKPLIAVPTTAGTGSETTGTAIFDLVSKRAKTGIAHRNLKPTLGICDPLNTRTMPSAVHASSGLDVLCHSLESWTAIPYFERIPRPQNPINRPAYQGANPISDIFSLQALRSTVQYLPRAVKDPEDHEAQSQMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPGYKHAGYQVETPIIPHGVSVAVSAPAVFRFTGPSNPERHLAAAEAFGVDISNVKRESAGEVLGEALTKFLADLGDQPKGLKDLGFKREHLDDLVEGTIPQARVLMLAPGLAEEVNEEREQLKQLFENAMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTM4</accession>
    <name>A0A194XTM4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G1/S-specific cyclin pas1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_183696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077846.1">
        <property type="nucleotide sequence ID" value="XM_018205641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTM4"/>
    <dbReference type="STRING" id="149040.A0A194XTM4"/>
    <dbReference type="GeneID" id="28815367"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_183696"/>
    <dbReference type="InParanoid" id="A0A194XTM4"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75860" checksum="3FC0A2642917968A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU61</accession>
    <name>A0A194XU61_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_744129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078031.1">
        <property type="nucleotide sequence ID" value="XM_018221024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU61"/>
    <dbReference type="STRING" id="149040.A0A194XU61"/>
    <dbReference type="GeneID" id="28830750"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744129"/>
    <dbReference type="InParanoid" id="A0A194XU61"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="20825" checksum="879D565420C0785E" modified="2016-10-05" version="1">MNLQETDWVLHLDEETIVDEHTVKNCIDFAEQQDQYDLGQGVIFYNAFGFWRQTLITFADIVRARDDLGKFYFAHNYFHVPVFGIHGSFLFINGKLENQIGWDTESLVEDFWFGIQAWNKGYKLGWIRSIAREQSPMTVLDLCKQRRRWFSGMLQLPGIWGRLACLQWCLSSVGATVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUB6</accession>
    <name>A0A194XUB6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_664032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077984.1">
        <property type="nucleotide sequence ID" value="XM_018212743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUB6"/>
    <dbReference type="GeneID" id="28822469"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664032"/>
    <dbReference type="InParanoid" id="A0A194XUB6"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="51087" checksum="9BC1C000F08664ED" modified="2016-10-05" version="1">MESLPGELLSTIFKCCEIPELLNLRQSCKAFHGPATRELFSSLHVIRQSDIETYDDLYSILSSSHISPEVTYIKITTSPDPYKEKDDYDNSEEESEFTENFEAVIQSISKFPNVQDVAIEFAQVCMLDDDPENVWRMMAEESVEFREDVLRTLFETLDKISKLRSLSIKHLQNYNDERILSLPAFASVLSRISDLKLKIVTESDFPSPQSGWNIRQLYSFFEELPDTWLKHTQDNLSSLTLDVDIEWGYMPVCNFRSLFFPRLKKLKLANYVFTHDWQLDWILSHETLEELVLTDCAIVNYMHVYEPLDAENCPLEPTNDFGDVRGWEYPRRWSEMFTKIEGMPNLRVFKFGSGNRDEGCDFDTGELTETGLHYMKYKGFHRRYRPSPWIPIGETTDVIENGDIADTRSEGENTDRMIESLDKDTLAYEKLMKTVMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUI3</accession>
    <name>A0A194XUI3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_728120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077722.1">
        <property type="nucleotide sequence ID" value="XM_018219231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUI3"/>
    <dbReference type="GeneID" id="28828957"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728120"/>
    <dbReference type="InParanoid" id="A0A194XUI3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="16288" checksum="3411DB1B96D4833E" modified="2016-10-05" version="1">MVLITTGCPRPTVINHCNFHSLQGHWDIPDIPDVSPGSGASQTPENLDQLRRDPQGFADYLEGKFHESKAAAMSVEFCYDSFSFFIKIHQILDPVQIVLDTCPPFCILPTIRGPVGWSVERNVLAIVECRHVFLESRGVDQLPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUW0</accession>
    <name>A0A194XUW0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_572752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078179.1">
        <property type="nucleotide sequence ID" value="XM_018208656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUW0"/>
    <dbReference type="STRING" id="149040.A0A194XUW0"/>
    <dbReference type="GeneID" id="28818382"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572752"/>
    <dbReference type="InParanoid" id="A0A194XUW0"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="77" mass="8512" checksum="8D269DBC8E181F19" modified="2016-10-05" version="1" fragment="single">MTLGPKVEAIKFKDAVGRMFTVPFENCKTFEAMKKVIEEAFLHVDVIGPHVLAGHFDLIGSNGEIMLPSLWASLIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUZ1</accession>
    <name>A0A194XUZ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_574175</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077882.1">
        <property type="nucleotide sequence ID" value="XM_018208724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUZ1"/>
    <dbReference type="FunCoup" id="A0A194XUZ1">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUZ1"/>
    <dbReference type="GeneID" id="28818450"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574175"/>
    <dbReference type="InParanoid" id="A0A194XUZ1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ23527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="440" mass="49854" checksum="0ED2840B3A886FD1" modified="2016-10-05" version="1">MSSKGWNPLQPDDLPRNFGGDDGNDTSMFSLGRHISAKAAAQPKLRCTELDENGNVVLASGEFKKSELIAKYGLLPRDLRKIDSSLLPHILVRPSAILINLLHLRVLIKSNRVLVFDAYGTTDSYNQSAFIYDLEDKLRQKQNSPSAGGLPYEFRALESVLISVITSLETEFEGVRKPVVRVLRELEEDIDRDKLRMLLIYSKKLGTFEQKAKLVRDAIDELLEADDDLAAMYLTEKSHDLLRGEDDHTEVEMLLESYHKLCDEIVQESGNLVSNIRNTEEIVKAILDANRNSLMVLDLKFSIGTLGMGSGAFIAALYGMNLKNFMEESDLGFLGVAGWSFVLSAFVCTYGLTKLRKVQRVSMWGEGGRRGRNWRDEDLDRAIVHREIEAGRAETRERHRKMKEQRLAAMEEMKAQMIRQRQEAAMQARLQASHQARKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW25</accession>
    <name>A0A194XW25_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_572978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078788.1">
        <property type="nucleotide sequence ID" value="XM_018208669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW25"/>
    <dbReference type="FunCoup" id="A0A194XW25">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XW25"/>
    <dbReference type="GeneID" id="28818395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572978"/>
    <dbReference type="InParanoid" id="A0A194XW25"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="78"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="430" mass="47467" checksum="C5FCA2137897A692" modified="2016-10-05" version="1">MKATPLSILPLSSIVRSLAITSISSSTLLLPPSLYIMAKLAHTNLPILSPDTNPVLQHFLKRTFYRQFCAGENSSEVHKTASNLRSLGFSGVILAYAKEVVLSESQHASLESCGESSAAEQCIREEIIPWANGTMETVKMTRPGDFVALKFTGAGSQALFDLSQETGPSEALREAIDGICSLAEARGVKLLFDAEQAAVQKGIDRWTLQYMQRYNCKTPGHATVYGTYQAYLKATPKVLAGHMKAAREGGFTLGVKLVRGAYLGSDPRHLIHDTKADTDRAYDGIAESLCRRSYGPILQAVDSEKKFPEVNVVLAGHNIHSVRKVKALRQQQKERGEQQIELVYAQLQGMADEVSCELVQAGLSEKREKAELDAPKVYKYLVWGTTGECMKYLLRRAQENKDAVQRTRDGRDAMANELWRRMRQTVGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWG0</accession>
    <name>A0A194XWG0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucanase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_19377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078714.1">
        <property type="nucleotide sequence ID" value="XM_018205724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWG0"/>
    <dbReference type="GeneID" id="28815450"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_19377"/>
    <dbReference type="InParanoid" id="A0A194XWG0"/>
    <dbReference type="OrthoDB" id="10058186at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="378" mass="39466" checksum="275D8A1E2398659A" modified="2016-10-05" version="1">MTNSTLSIQLQNQTSSSTVYAYITGIDASNGSFVLIQADGHSTYYPQSPSSVGSPLAVDCGIKLGAPGSSTPATIPQMAGGRIWFCINNTLTFLLNPGPGLVEPSVSNPSDPNYSKTWGFCEFTFNSFQLFANITYVDFVSVPIQLSLTNTSGAVQNVPGIPSGGLGTVCSGLQAQNAVDNAGWNQLIVNNSSGQPLRALSPNTGIVMNNNLFSGYYANYVSQVWAQYASNQLSVNTQAQWGTTAASIQNGLLTFPGVGTFAQPSAADIFSCSTGPFSAASWPQANTAEMGNLTARLAAAFNRSTLLLNANQPDGEVIASYYQNPVTNHYSRIVHATAAGGLGYAFPYDDVAPSGQAGVAGTVSDGNPEVFTITVLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B198</accession>
    <name>A0A132B198_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_603774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947459">
        <property type="protein sequence ID" value="KUJ06148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060503.1">
        <property type="nucleotide sequence ID" value="XM_018210325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B198"/>
    <dbReference type="GeneID" id="28820051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603774"/>
    <dbReference type="InParanoid" id="A0A132B198"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="8283" checksum="1FCF7AFF02699122" modified="2016-05-11" version="1" fragment="single">VLNSFGWGLFAFLGSLATSFINVHYIAELNFFVSVINIIGLMFGSPLFAVLFSKGVELEEKWYSLPFSFALKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1R2</accession>
    <name>A0A132B1R2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_412846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060671.1">
        <property type="nucleotide sequence ID" value="XM_018207345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1R2"/>
    <dbReference type="GeneID" id="28817071"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_412846"/>
    <dbReference type="InParanoid" id="A0A132B1R2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="61" mass="7107" checksum="B1D3BCB9AF648C46" modified="2016-05-11" version="1">MTVAPVLILYCITLIVSLRRYCFHFASNVVRYRCRSTQELPTFVSPSTQVTQSRFYSPLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1T1</accession>
    <name>A0A132B1T1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_790704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="13191" checksum="C6CD89DB17F3CBE4" modified="2016-05-11" version="1">MMSSQEKQTKSPRARAEARAEAKADNDLSFGSEPEFLKNNNEFEHHAACLLNNPLTDPAFDDNTENEDEMNAKQVMDAFMEAQKRWFFFIVALVFGLLFLLAALVLGWGHARYRY</sequence>
</entry>
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            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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    </dbReference>
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            <begin position="1"/>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28448" checksum="64B25B9F0E8D6AEC" modified="2016-05-11" version="1">MADIEDRGGSTHFEHSVPAATPNTDNRCEDSSGATNKFERFNDLPIELRLRIWTIASFFPRNVCVEVDRWFQCGIEQEDWGHLGAFRVPVTYTSNCPVPTVLHVCKESRKEALKYYSLEFGGHQENEVDDYERSYTISIPPVVYFNWKADTLFTPRTFSITGGIEDYGLDLARMVNFVDIEPGTHGARWDSVLREADSDGLRSVMKSLLGGNAEPFLKFWHWFSGLTNPPRIRICELANIELCPENPEF</sequence>
</entry>
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        </submittedName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF3433"/>
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        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
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        <location>
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            <end position="206"/>
        </location>
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        <location>
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        <location>
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        </location>
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            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ06722.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="801" mass="91043" checksum="0FBBDC7A89732557" modified="2016-05-11" version="1"> </sequence>
</entry>
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    <accession>A0A132B2W7</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="192" mass="22540" checksum="99DBB23CCE3C41CD" modified="2016-05-11" version="1">MTKEALGASSVYVYDWRYRKGGTTYDDRNLEEDIKNTRYVIYAPIGYVHSDYSYQGGLDRLFLHLTEPELESYKKQGARMRLINAWRPLRKVENAPLAMCDRRSVLPEDVIEVDKVLPNNLEVETCIYHRPYHKWYFMSEQTPDDVWLFVQWEECDVPCETTSVPHTALNGPQVRLGDMPRESLEVRMIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3B0"/>
    <dbReference type="GeneID" id="28828769"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726283"/>
    <dbReference type="InParanoid" id="A0A132B3B0"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fun_TF"/>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="623" mass="71684" checksum="93E2D9DABEC50F2E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3I7</accession>
    <name>A0A132B3I7_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">LY89DRAFT_374327</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ06965.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="563" mass="63318" checksum="5364CBE818CC8A13" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3M8</accession>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3M8"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_692070"/>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="11485" checksum="B0632E4569C26EED" modified="2016-05-11" version="1">MQNIPKINPSELLSRAHFFLVVLVVFLSLKAITMCITPSCIQNRLQAVLRLELGAIMSVLCSLFVLGVKLYPGSDIHQAYELVGRSARTDFEPLLCGFGLLGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3N1</accession>
    <name>A0A132B3N1_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_414764</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3N1"/>
    <dbReference type="GeneID" id="28817083"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_414764"/>
    <dbReference type="InParanoid" id="A0A132B3N1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="17162" checksum="842428003C2A77DB" modified="2016-05-11" version="1">MRGRSFSCCRCSSLPAICFICTALSISLQPELGFSIFSKFATSILSASGFSAVSGEPGWQLCTSILPRLVWMILSVNSISSINRRDSSTMRASKAKLPIARVNQFSRSIPKLLSNMMLNCCTIVSFHCVILVCTLAPSNEDQARPPIHLVHECSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3T9</accession>
    <name>A0A132B3T9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-fucose:H+ symporter permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_602266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061346.1">
        <property type="nucleotide sequence ID" value="XM_018210236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3T9"/>
    <dbReference type="GeneID" id="28819962"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602266"/>
    <dbReference type="InParanoid" id="A0A132B3T9"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="50421" checksum="315C2CF1B3D2A354" modified="2016-05-11" version="1">MAGGVPIAAPTLASGFLRGKDLIFPLSLVISLFFLWGFSYGLLDVLNKHFQTVLDITKLQSTGLQVVYFGGGYLLFSPVAAEVMKRKGYKVTILMGLSLYSLGAIFFWPTAHFSTYEHRIASFGGFCACTLVIACGLATLETAANSYAVVIGDPASASARLQFCQSWNGVASFIGPLIASKFFFSGKNANNLVNVQFVYLAVACAGVAIAVLFLVAKLPEVSEEMLNSSTVENYATDEFGQEIGQGPIYKQYNMIFGFIAQFCYVGAQVTIASFFINYATENATFTSAQASNLLSYALITFTVGRFVATALATVFQADFLLMIYAAIAIALNAVICAAHGNAAVGVLIAIFFLEAPMYPTLFTLGTANLGRHTRRGAGILVMGVSGGAVFPPIQGAIADSAGTRISYVVPLVGFVYVLGYVTAHWLRTGRHIMRVKDIVAAGTAGGALGGVVETVHYDGDKDLKVEEAELSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3V6</accession>
    <name>A0A132B3V6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_565026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060959.1">
        <property type="nucleotide sequence ID" value="XM_018208528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3V6"/>
    <dbReference type="FunCoup" id="A0A132B3V6">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B3V6"/>
    <dbReference type="GeneID" id="28818254"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_565026"/>
    <dbReference type="InParanoid" id="A0A132B3V6"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="31430" checksum="EC78DE2E32191264" modified="2016-05-11" version="1" fragment="single">RTQRAVPSRPLRSNSQRQFVTEAINASHTALQSVHDLSGLPWALSLPLFALVLRTTFILPLSIYQRRAAQRQVQLEPLIQAWRFTLQKQAMKQYGHLGPQVAEQALISSLRKKRREIYRRYRCGIWKGFLGLAQLPVFLTIMEALRNMSGSSQGWIGMMFGDGLVAEAIRIPVESSFANEGMLWFPDLLVADPQLVLPFILSGTILLNVFGGGIKGQDLALPKWQVRLKRNMGLVALCIGPIMIHVPSALVLYWLSSSGFAFLQASILERVMPIKSAPKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Y7</accession>
    <name>A0A132B3Y7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase Ure2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_692265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060989.1">
        <property type="nucleotide sequence ID" value="XM_018216501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Y7"/>
    <dbReference type="FunCoup" id="A0A132B3Y7">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B3Y7"/>
    <dbReference type="GeneID" id="28826227"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692265"/>
    <dbReference type="InParanoid" id="A0A132B3Y7"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="25194" checksum="9BDE6E79D6549CD9" modified="2016-05-11" version="1">MSSEIKPITVWGKGGPNPPKVAILLGELGLPVEFIIVPLSKVKEPEFLAINPNGRIPAIHDPNTDLTLWESGAIIEYLIERYDTEHKFSFPAGTPEAYHAKQWLFFAASGQGPYYGQLGWFKLYHEEKIPSAIERYVKEVNRVTGVLDGHLAKQKVGPDSDGPWLVGDKYSFADMVFVSWQKIISLVTTKEEYSLDAYPHVKEWHGKMMERGPVKEAMAAGKPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B538</accession>
    <name>A0A132B538_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_630995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061806.1">
        <property type="nucleotide sequence ID" value="XM_018211259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B538"/>
    <dbReference type="STRING" id="149040.A0A132B538"/>
    <dbReference type="GeneID" id="28820985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630995"/>
    <dbReference type="InParanoid" id="A0A132B538"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="491" mass="53087" checksum="CBE4B26BDDD6FF33" modified="2016-05-11" version="1">MISIDELTIDQVHSAYKQGSHTCRQLVEAYIERIKTLDQAGPKLNAITTISPFALEEADFIDTHFKEHGKFIGSLHGVPVIVKDQCDTKGVETTYGNICCKHIPSQDATLVRKLRDAGAVILAKSTMPDFAASFNSASSVSGETLNPYDTTRETGGSSAGTGAAIAANYGLIGVGEDTGGSIRVPASFCNLVGLRPTVGLVSRFGLSPLVKTQDTPGPMTRTVKDAALMLDVLVGYDSKDTYTAAAAIAGPPRGGSYASNLSKYVLSRARIGVLNAVFGEGEECAPVNQIIRDTLSKFTAGTTLIDVDIPNLDYYLNFSSTYFSRSRYDIDNFLSAHPIIKNVTVESIHKSKQFHQALPLFDRIGTGPKHPYEDAHYAARLDERDEFQRIVIGIMTEHNLDAIAYPSVQIPAPTIKDVLGPRFKENPFLTNTTIGSQLRQPAISVPVGFTEPGLPVGLELLGMPYSEQKLLELAYGVEVLTKARRAPKFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5C3</accession>
    <name>A0A132B5C3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SIN1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_368173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061449.1">
        <property type="nucleotide sequence ID" value="XM_018207037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5C3"/>
    <dbReference type="STRING" id="149040.A0A132B5C3"/>
    <dbReference type="GeneID" id="28816763"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_368173"/>
    <dbReference type="InParanoid" id="A0A132B5C3"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="335"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="701"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="809" mass="88683" checksum="86A9BC1BD8BF10AE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5D5</accession>
    <name>A0A132B5D5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_712030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061906.1">
        <property type="nucleotide sequence ID" value="XM_018217949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5D5"/>
    <dbReference type="GeneID" id="28827675"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712030"/>
    <dbReference type="InParanoid" id="A0A132B5D5"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="183"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ07551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="614" mass="66448" checksum="1F870E5A26B9DDC1" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7B4</accession>
    <name>A0A132B7B4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_538211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062488.1">
        <property type="nucleotide sequence ID" value="XM_018208126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7B4"/>
    <dbReference type="STRING" id="149040.A0A132B7B4"/>
    <dbReference type="GeneID" id="28817852"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_538211"/>
    <dbReference type="InParanoid" id="A0A132B7B4"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31474" checksum="678F22ACD9EFAB3A" modified="2016-05-11" version="1" fragment="single">ENRPVTIIGAGVLGRRLAVIWASTGRDVNLYDTHPSAFDSATPYIADTLSTYCSTHGTHPGHVHFSTSLLPSLSNSWLIIECVPEDLELKISVLGRLDRLAPKDAIIATNSSSFASRDLVPEVKHRERVLNTLYYVPPANRCVELMSCGYTSPTLTSFLVSQMRTVNLLPFLVNHESTGMIFPRLWAALKRETLQILKDDVAKPEEIDELFRDFFGAKQGVCEKMDEIGLDTIAKVEGRFLDERERRNETDLWRGRGHLRWLEREFVEKGWLGEKSGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7C0</accession>
    <name>A0A132B7C0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_701989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062663.1">
        <property type="nucleotide sequence ID" value="XM_018217226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7C0"/>
    <dbReference type="STRING" id="149040.A0A132B7C0"/>
    <dbReference type="GeneID" id="28826952"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701989"/>
    <dbReference type="InParanoid" id="A0A132B7C0"/>
    <dbReference type="OrthoDB" id="4104179at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="522" mass="57464" checksum="4B4F5A08C725EC0E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7R3</accession>
    <name>A0A132B7R3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-carbamoyl-D-amino acid hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_788825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062797.1">
        <property type="nucleotide sequence ID" value="XM_018223196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7R3"/>
    <dbReference type="STRING" id="149040.A0A132B7R3"/>
    <dbReference type="GeneID" id="28832922"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788825"/>
    <dbReference type="InParanoid" id="A0A132B7R3"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF12">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="344" mass="38270" checksum="4C6B6AC6321A7D8B" modified="2016-05-11" version="1">MPRTLKVAAAQMGPIHLTSKRPETLSRMLALLRTASKLGAQLVLFPETAFTTFFPRHLINSQEELDSYFEHEDNVPESANTKPLFDEAKTLGIDISIGFAERTADGKGYNTSIYFSAKKGEVIAKYRKVHLPGTKEPFANPDAVNQLEKRYFEPGNLGFKAFRTPDLIPGAAKKESGIKEHGKGDPIMGMMICNDRRWAEGWRCYGLQGVEIVLCGYNTAGFAPDLWGTRKPMIPEEAEKDAVFHHKLVMQGNSYMNSCFSISAAKAGLEDAKYDLIGGSCITSPEGHVLAEAKTKDDEVVFAEIDLEDCRQGKEKTFDFDRHRRVDQYGPITIQTGVVEPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7Y4</accession>
    <name>A0A132B7Y4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_677417</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062454.1">
        <property type="nucleotide sequence ID" value="XM_018213679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7Y4"/>
    <dbReference type="FunCoup" id="A0A132B7Y4">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B7Y4"/>
    <dbReference type="GeneID" id="28823405"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677417"/>
    <dbReference type="InParanoid" id="A0A132B7Y4"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="203"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="302"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="457"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="377"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="502"/>
            <end position="506"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KUJ08099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="58848" checksum="E3C977A642EC9F45" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9F6</accession>
    <name>A0A132B9F6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_598617</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063391.1">
        <property type="nucleotide sequence ID" value="XM_018210052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9F6"/>
    <dbReference type="STRING" id="149040.A0A132B9F6"/>
    <dbReference type="GeneID" id="28819778"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598617"/>
    <dbReference type="InParanoid" id="A0A132B9F6"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
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        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0456">Lyase</keyword>
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    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
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            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="404"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="483"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023052"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="584" mass="64262" checksum="96C59B8E76A32554" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9X1</accession>
    <name>A0A132B9X1_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_690697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_690697"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21214" checksum="E51EC25087DCBA1C" modified="2016-05-11" version="1" fragment="single">MSPKRKSAGEDSTTQAKKARPSTTATPSTPTAPTPSVKESPAIKDLSLDIPSHEKAFKAVYRQLKKSVRENWHDRYDDHNELQLELVTLLVAWQQEIFHCAILPGERLLEAYKAMVVVDEWIQKERGNEFNVRVDWREGDASWSVDDVEGKKVYEGLPENIQAKMWRDLLLKSFVTCEAATTVEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211189.1"/>
    </dbReference>
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        <property type="interactions" value="1164"/>
    </dbReference>
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    <dbReference type="GeneID" id="28820915"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628827"/>
    <dbReference type="InParanoid" id="A0A132BAH1"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="34963" checksum="643FE745E5D18DCE" modified="2016-05-11" version="1">MASVYKSLSKTNGHKEDGPANGVKKNKQRVLILSSRGITYRHRHLLNDLASLLPHGRKDAKLDTKSKLYQLNELAELYSCNNVFFFEARKGKDLYLWMSKAPNGPTVKMHMQNLHTMEELHFTGNCLKGSRPILSFDAKFDSEPHLRVLKELFLHIFGVPKGARKSKPFIDHVMGFTLADGKIWIRNYQINETEPSKVVPADSEDAPKSKEKSSGKSKETEISLVEIGPRFVLTPIVIQEGSFGGPIIYENKEFVSPNQVRSEIRLKKAGRYNARAEQGIERLAKKGELGLRTSGGRAAKKDELDTAELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC41</accession>
    <name>A0A132BC41_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_740401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064347.1">
        <property type="nucleotide sequence ID" value="XM_018220583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC41"/>
    <dbReference type="GeneID" id="28830309"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740401"/>
    <dbReference type="InParanoid" id="A0A132BC41"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="40122" checksum="CF897935362310DC" modified="2016-05-11" version="1">MDPSSFNGKTVWSWPRTQPVSFTEETQKGKSQSRFNTFEYWNYDLGSGIDPVLNAEIVEEDDFSTWLKRQPVIKSPSSSLRLVFFVQPIRSAIPFKKSNFETMCEIFGLPPVELHWASDQTGACGMFVTEGDEYTVICSQDINSSALACTIRYQSASNITSGYIRTSFPTEFQDLDLTSQYHACPHPILIPVLLIEYAVRNISVNMYNISSEVWKIKEQTMREDLPTVEYKKLSCRASDIAGKLIMKASALELNLLRLNTLEKKLAYMDTHLPSSSMQKLSTHSVALHSRIAFISNSVEHALLLREAWVERCRFSQSLLSDLIGLQNMSPVGQVVPVCPQCHPSAGSDGQPPRYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC56</accession>
    <name>A0A132BC56_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_740416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064365.1">
        <property type="nucleotide sequence ID" value="XM_018220584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC56"/>
    <dbReference type="STRING" id="149040.A0A132BC56"/>
    <dbReference type="GeneID" id="28830310"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740416"/>
    <dbReference type="InParanoid" id="A0A132BC56"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="406" mass="46750" checksum="6E5E654F0C52C27B" modified="2016-05-11" version="1">MSFYPLLYFGVELELNVAYIYPNEVIEDITELKPSSFRPTESMIDQASAYLFRNKISYAKLFNEKNFSDEILRIEVMKRTIYQSIRDDLRAAGLPINQTPAQVSPVLVDVSKWDIEGDTSISPPNNKYHWLGVELKSPAYDFTPENLAAVQKVCKILTTKYLTNTNESTGLHVHVSFGTDIRWRLRSVKQAMMFFWAFHHQFDTLHPANRQGDSQYTQSMRGYSSMSANHLTQTGHRITAYEGCKLLEKHEDMEALVRAVCEEGTVPNRYMAYNVKPIFNLLRPDLSSETPKTTIEFRQHEGTLDGERVTQWVKLLCGVIRWIEIVEPSSLMNLMRLTKHETWSKTGDKAQDDLNESKFGPVLAEGPFMITDLLEHMSLQESADFYRRRLYEVSGGVSEDQEFVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDU6</accession>
    <name>A0A132BDU6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064778.1">
        <property type="nucleotide sequence ID" value="XM_018215949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDU6"/>
    <dbReference type="GeneID" id="28825675"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689670"/>
    <dbReference type="InParanoid" id="A0A132BDU6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="70" mass="7868" checksum="4ADFA5C00ADA4D90" modified="2016-05-11" version="1">MDLTSGFSLLRTVFLMAHAVEDIRQELFGISQFGSDFWETCKNIEQFNCQISRTISNQPAPESSIILALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEC5</accession>
    <name>A0A132BEC5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_760850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064382.1">
        <property type="nucleotide sequence ID" value="XM_018221523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEC5"/>
    <dbReference type="GeneID" id="28831249"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760850"/>
    <dbReference type="InParanoid" id="A0A132BEC5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="212" mass="24138" checksum="91AD74E0BB171832" modified="2016-05-11" version="1">MCPVIWTFACGHVLQGTGPERFPPRTTSLTSPHACPACQLSAIPATDQLKEELAREFDNHKQTLSFLEKELDLHRDQVKNVNVDNKEMNAYLDRIGPFLMWSWAKMVADFHVKMWTHPRVEVFRDCLRSTMMQDIQSVIMAVDAMAKANILEHKHGSTKLDDEDIIILGRKLPNILAQHESNPEVGLDEREKELIEAWKTVLALIKKADVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSL8</accession>
    <name>A0A194WSL8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065308.1">
        <property type="nucleotide sequence ID" value="XM_018220530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSL8"/>
    <dbReference type="STRING" id="149040.A0A194WSL8"/>
    <dbReference type="GeneID" id="28830256"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739928"/>
    <dbReference type="InParanoid" id="A0A194WSL8"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56278" checksum="F4EDF597EA8082C0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSV0</accession>
    <name>A0A194WSV0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_700358</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065390.1">
        <property type="nucleotide sequence ID" value="XM_018217115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSV0"/>
    <dbReference type="GeneID" id="28826841"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700358"/>
    <dbReference type="InParanoid" id="A0A194WSV0"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="679" mass="76904" checksum="97F92FDC07E6EE66" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT60</accession>
    <name>A0A194WT60_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_710302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065501.1">
        <property type="nucleotide sequence ID" value="XM_018217819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT60"/>
    <dbReference type="GeneID" id="28827545"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710302"/>
    <dbReference type="InParanoid" id="A0A194WT60"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="457" mass="51656" checksum="1E14032324009109" modified="2016-10-05" version="1">MGAKPQVDTQFNVTSGCLCYGDIHNVWHGTSSPICKFPTSVEQHAGGTVTAQIISFNTLVEKGTDRLCAWFASHVDVDPEVEIDKILNVSGSPYERDSGSRLNDKKTAKESVLVINRYDWGYYDKRGKEELGIDDTAETDWATWVFGEGAALVDFESAKTEVLRWNEKKRQERDNSPNGVWMFIPGGEYMFGRFGFDEDRSGARSFLFFTTYTNFCSTSFVGTDRALRVEETDEEWFQRCLRKEGYFEGLVELKQQISWFNGPLHLPAESEYLGPYDSRECILTSTDIDAIRIRPGVKAHEFADPLKEDCLTCLNEMIMSYLEHFIAPASSHNTVVAACCLIPYSDPIPGFNDRAVGSKIKSFLIPRCEDKSLVRDEKFIAGICACIAYLLSEVLELANNHAGRRSKLIPVDIRLAVFMDTKLRDLFKYSRFFWKGNSQIFQVAGASRTTELTQTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVP2</accession>
    <name>A0A194WVP2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_722419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066396.1">
        <property type="nucleotide sequence ID" value="XM_018218730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVP2"/>
    <dbReference type="STRING" id="149040.A0A194WVP2"/>
    <dbReference type="GeneID" id="28828456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722419"/>
    <dbReference type="InParanoid" id="A0A194WVP2"/>
    <dbReference type="OrthoDB" id="192702at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021276">
        <property type="entry name" value="DUF2855"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11017">
        <property type="entry name" value="DUF2855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="422" mass="45994" checksum="C22912E8797BB13B" modified="2016-10-05" version="1">MASSVPVIQVLSRNNYEDQHIVALPESSSLPTLPPSSLRIKTSILSLTTNNFSYARIGHLLGWWDIHLLPESIPAEYADPKKFGRISGWGYGIVLESNVSEIQVGTQLYGYLPIGTLPVDVEIQIDTQVPNQIVVTSKHRQHVLPIYNRYLAFPPANTSEGTTQEQHSKGYDSLMQVLFETSYMMNRFVFASESAELVHPSGDPNDGWTLEKADIGPKTTVVIFSPSGKTALAFAHQLKHSRPVGKLPHAIIGVGSSASQAFSEGTGLYDKVLIYEADSGDLSLELGLQADSKIIVCDFGARGNAPARWAAKLKPSYSSLVQLDIGGEVVPDSPEKTTEKFMARMGGPLIINASALRSQAMAIVGEKKYFEEFLKEWEAFKAQGGVKGLGLIWGSGMDDVKKGWEALCRGEVGPNQGLVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWF1</accession>
    <name>A0A194WWF1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_204393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066630.1">
        <property type="nucleotide sequence ID" value="XM_018205807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWF1"/>
    <dbReference type="GeneID" id="28815533"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_204393"/>
    <dbReference type="InParanoid" id="A0A194WWF1"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39293" checksum="04C772A7FE6FCCB4" modified="2016-10-05" version="1">MAKDLDLLVREILVVNSTDIPHKGPHVTKVPLQTISKLAPFSALIISIIFVVYFVVRFYVLEGFLLRRLYGETYTRMDETTRRGFVNHHIAGSTKLLILVLAAYPFVDVAFGTANFHTPFAGSHYVTMGDVLIIVAQMLIAMYVFELFYRPKISPVSVGHHIGTIMIGQSAIAISLNLVRERDATIEFILCTVWGAFDIVSEFLPHISIILYRVYPNEHKFLYKIFRICCVSTLIGTTAETALTMYLFGVLWYDWTIAFKITTPMLHVLFASAQLWGSYNFYKMFKKQERIILRLDGKSGDEEAAPKPEQDNTRQEQIFISSMDGDRSGQPSRDGSEVELTVNPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWK2</accession>
    <name>A0A194WWK2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_220831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
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        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
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        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
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        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
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    </dbReference>
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        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7439" checksum="BC35EA25FD705F09" modified="2016-10-05" version="1">MVARRGFHSTRAQLSSPYHYPEGPRSNIPFNPLTKWFALRYWTFMAVGFGAPFGVAVWQTYKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXH4</accession>
    <name>A0A194WXH4_MOLSC</name>
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        <submittedName>
            <fullName evidence="10">AAT family amino acid transporter, variant</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">LY89DRAFT_653126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="73"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="540" mass="60141" checksum="351788A884FDC223" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY59</accession>
    <name>A0A194WY59_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_738397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066979.1">
        <property type="nucleotide sequence ID" value="XM_018220367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY59"/>
    <dbReference type="GeneID" id="28830093"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738397"/>
    <dbReference type="InParanoid" id="A0A194WY59"/>
    <dbReference type="OrthoDB" id="3564733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="148" mass="16389" checksum="16F7D338FE2985F2" modified="2016-10-05" version="1">MVLILAATIGKMIYDEVKDHKGKKNGTHKRSKSDPSQSRRLSMDKPLPSTPLQTSNIEPSTALQTNNTDPSPTSLYEVSPVEGVYEMDVAPPPYQATSPVIPERSPLRVKVGNDVVPWSPDDIVRPSIEEVRASDVRRKPSPQVFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYE2</accession>
    <name>A0A194WYE2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_591866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067336.1">
        <property type="nucleotide sequence ID" value="XM_018209669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYE2"/>
    <dbReference type="GeneID" id="28819395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591866"/>
    <dbReference type="InParanoid" id="A0A194WYE2"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="49"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36096" checksum="D859D3FFE99F3C3A" modified="2016-10-05" version="1">MTYPKPPGQERPYPKPTRTGKIPFKIPNHDIQGETAYEIYGDLKSGKTPLITLHGGPGFQHSYLLPMSLLLIDYGIPVIMYDQIGCGESTRYPDRMGDTAFWNPELFIAELGNLKEALGIEAFDLLGQSWGGMLAAQYVTTVQPKGLRKLIISDSLAAMRLWQNSANKLRKSLPAEIQETMARCEKEGKMESPEYEAACNEFNKRYSCRLDPIPAELAGPIEALTTDATVAMTMFGPSDFIVTGSLKDWSIEEDLKKLTPEVVPGGMLLMNGYFDVAQDEVMFPFFKEPSTKVKWVRFGLSSHCPQLEETEKYVKALGDFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ16</accession>
    <name>A0A194WZ16_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_737743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067192.1">
        <property type="nucleotide sequence ID" value="XM_018220294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ16"/>
    <dbReference type="GeneID" id="28830020"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737743"/>
    <dbReference type="InParanoid" id="A0A194WZ16"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="244" mass="27755" checksum="5684E162F3552A9D" modified="2016-10-05" version="1">MYTKRIEHKNPEANIKALQDLNRTGRTIFAKTSLEYKTLMGAPPRLAGEPGIDIENPDHCTSLIPKGTLPVLLSPRSFLEYAFRYPYYAYVEHELKLGYKVDTSVGSTSLLHSATCAGDYKMMQILLRYGADPNYHSEIDPTCSNSWEQHIELSLLRNSWKVGGSNELDREAKTIALFLEYKADTRAVVQGQSVKSIIYRFKDWDKGRTAELLEKFDVARKAQARPNRLSIMFANLGRTNSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1F6</accession>
    <name>A0A194X1F6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Retrograde regulation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_621274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068037.1">
        <property type="nucleotide sequence ID" value="XM_018210942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1F6"/>
    <dbReference type="GeneID" id="28820668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_621274"/>
    <dbReference type="InParanoid" id="A0A194X1F6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="56284" checksum="49FA58E0D570FA64" modified="2016-10-05" version="1">MSEYPSASEKVHEIPRAEDPPSSLDDEKVEQERVEDVGEKRLPGDGEARLPRFTQEEEEAVIRKLDWHLMPLIFVLYSLSVLDRSNLGNAKVAGMQDDIDIAGNRYNWLGTIFYISYILFQWTQMGFKIFPPHRWAACAVLAWGIISSAQAATTTWAGLMVCRFLLAIPEAMYGPAVPLYLSFFYPRERLGLRTGIFLSGSALANAYGGALAYGISQAKGSIASWRILFLVEGLPTIVLAFVAWFWLPDSPAKARFLSERDREVAIELSQRQPGDRNNDKFQWKQAVGALLDYRSYIPPLIYFGCNVCFASLPLFVPTIISQMGAFTTIQSNGLSAPPYVLCFISIVACAFISDRVGVRGPFVAGAGLVAAIGYILLATQTTVAVRYFGLFLATIIFTSVALVLSWVANTHATDSKRAAGLAILATGGQCGPILGTNIFPAGDKPYYRKGMWISCGACLLVFFLASLQSFLLWRENKQRDKKYGKVRDTEHTNVQSEFGDDANFRYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X241</accession>
    <name>A0A194X241_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068598.1">
        <property type="nucleotide sequence ID" value="XM_018215357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X241"/>
    <dbReference type="GeneID" id="28825083"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686747"/>
    <dbReference type="InParanoid" id="A0A194X241"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267790" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="82" mass="8791" checksum="14454AA67738E951" modified="2016-10-05" version="1">MYFTSYLQILALSFSAITIAIPIAPRVAPNIELEVADPILDIEARAAPDITFEVADPIVDIEARAAPDITLEVADPVVDIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2M2</accession>
    <name>A0A194X2M2_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">Putative methylsterol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_138810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068790.1">
        <property type="nucleotide sequence ID" value="XM_018205301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2M2"/>
    <dbReference type="FunCoup" id="A0A194X2M2">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2M2"/>
    <dbReference type="GeneID" id="28815027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_138810"/>
    <dbReference type="InParanoid" id="A0A194X2M2"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="147"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="35874" checksum="7DD1806254B28E34" modified="2016-10-05" version="1">MDSLLANGTLNATLVSSDTYFGIYNELSKYNIQLNIFERLWATWYAYMQNDVLATGIMSFVMHEAVYFGRSIPWIIIDQIPYFNKYKLQGAKIPTMKEQWTCTKLVILSHFTVELPQIWLFHPMAKSCGMDTGVPFPAWQTMAIQIAIFFVLEDTWHYWMHRLFHWGFFYKNIHKIHHQYSAPFGLAAEYASPIETMVLGAGTVIIPIIWCLVTQNLHVLTMYLWITCRLFQAIDAHSGYDFPWSLHHFLPFWAGAEHHDVHHEQFIGNYASSFRWWDYVMDTESGPEAAKKRRERKQAKLAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2S2</accession>
    <name>A0A194X2S2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_736507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068828.1">
        <property type="nucleotide sequence ID" value="XM_018220128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2S2"/>
    <dbReference type="GeneID" id="28829854"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736507"/>
    <dbReference type="InParanoid" id="A0A194X2S2"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="33478" checksum="E22ADF6CC2E2DAF9" modified="2016-10-05" version="1">MSSTTGPSIITDATSISAFNRGPIPTQFSAPTSCLSTLTSVNGAGGLYFGHNGDEYFDTACFPTPTLTTSSVQWNLYYYSPVISCPSGWYTAAVATSSFGGLSDTYLSIGSATTAALCCPSGYTALNYDHQCDSQFPLGTNTILYKNPSSAINGDWVVPTTVDTALYVAATASATSYWTVFGDGIPIWFEARDLSTATQTSTPTPTTSPISSTTSATSTGSSGLTTGAKAGIGIGVSLGVVTIAALIGWFLFRRKRRYDAVNRGTPVRELESIGSEKRNSELPAQDVSRPVVHELYSDEGVPVQQRVLHDNGPSEVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2Y4</accession>
    <name>A0A194X2Y4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_650422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068903.1">
        <property type="nucleotide sequence ID" value="XM_018212104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2Y4"/>
    <dbReference type="STRING" id="149040.A0A194X2Y4"/>
    <dbReference type="GeneID" id="28821830"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650422"/>
    <dbReference type="InParanoid" id="A0A194X2Y4"/>
    <dbReference type="OrthoDB" id="3563777at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="583" mass="66423" checksum="E7F3D369F84C8EA5" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X357</accession>
    <name>A0A194X357_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_117408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205118.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28814844"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_117408"/>
    <dbReference type="InParanoid" id="A0A194X357"/>
    <dbReference type="OrthoDB" id="5294606at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="432" mass="46619" checksum="19987E86052010CA" modified="2016-10-05" version="1">MKFIVLSFIFLLAVVSAELETADANGTCRTISARGQQEYCLWTNTYNPPASVNLYGDICGAAPWYNVSDTGMAPICNPNESFTLDPNGALTWQLELTDVKCADPVGQYWQYFNYTWSCCLCPPGWVTVNGPPLYCDAFKSCVRCSGADEELEFIPSPSGGNERVATCITTTMPSTISSSTTSSTTPPATSAACGSSNKRDFLTGRAAACTACLDLTTLTDPALAGHQTIINTEFLPKVKDMISCATRNGWDQLLDASSSRCYLSRGSYAGTHPSAHMIGQAMDVNLSGGIHKACDRQCFLEAYCVHNLSFGLCKNVLDTFTRRNPTDKDTAVYNFINCVGQIPDMVIGAKIPVPIKKKPGKTQGDWDHFQGIPAKPYAIGVYDTYHEQLVQFCQGGCLNAPVNLEKGEGPSDEACPQPPKATCAVHGIDFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_736583"/>
    <dbReference type="InParanoid" id="A0A194X406"/>
    <dbReference type="OrthoDB" id="3509926at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267882" description="Secreted protein" evidence="1">
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            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21986" checksum="8C1E3A349CDEBDF8" modified="2016-10-05" version="1">MKHHLSNMLLVLTGFLAAVTCTAIPLSGTQRANTTNHISPRTNDVTIYDFVYTIAGESKYKTYICEVYPEPNVCIATMVDVFTQYSHSDYVQMWMFDNKCNQIGNNGNTVTRDDLAAPGGWGFSSELEDFLVVHIPRDWPNSGQATFDYNSQTTLQPDPDNRYNSQISVGPPSQEETDGFIYTLVGQFDCTSPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X444</accession>
    <name>A0A194X444_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_126000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069308.1">
        <property type="nucleotide sequence ID" value="XM_018205196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X444"/>
    <dbReference type="GeneID" id="28814922"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_126000"/>
    <dbReference type="InParanoid" id="A0A194X444"/>
    <dbReference type="OrthoDB" id="10383216at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16901" checksum="64C49E3B57BFFE17" modified="2016-10-05" version="1">MSYLRNKQHMRPRPRCTHRNVFKAPRIYTQEDHHITYIIDSYTIQITWFQSSHIPSQPSQKAAFERLVAEAALSLNQTEVHIRSKLQNDATEGGQVVHYDRHILVWFPKMKREAHVYVGPTEVVKIEELRVWRREGRVAVVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4K0</accession>
    <name>A0A194X4K0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_671495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069463.1">
        <property type="nucleotide sequence ID" value="XM_018213219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4K0"/>
    <dbReference type="STRING" id="149040.A0A194X4K0"/>
    <dbReference type="GeneID" id="28822945"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671495"/>
    <dbReference type="InParanoid" id="A0A194X4K0"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="745" mass="81877" checksum="EB181979EA0B2CDB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4Q3</accession>
    <name>A0A194X4Q3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_128325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069399.1">
        <property type="nucleotide sequence ID" value="XM_018205219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4Q3"/>
    <dbReference type="STRING" id="149040.A0A194X4Q3"/>
    <dbReference type="GeneID" id="28814945"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_128325"/>
    <dbReference type="InParanoid" id="A0A194X4Q3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
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    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
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        <property type="entry name" value="P450"/>
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    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="496" mass="56222" checksum="63F5B6B2F43E13B5" modified="2016-10-05" version="1">MAYLNELSSLGSLLAISYVLTILAVSYVLGLAIYNLYFHPLASYPGPKLNAISRIPYLWALVNGNQVRQVHDLHQQYGIVVRVCPDELSYISAEAFKDIYAHRQGKLEMQKNKIFYTQQPGGTTLLTTNREDHALQRRSLSHAFSDSYLRQQEVLIQKYIDLLIQRLEQHADDGSKPLNLVSWYNFTTFDIIGDLTFGESFDCLEKSDYHPWVSMIFSNMKASSYLKALKYVPGGTGISSLIVPKRLLETLKSHANIITEKLNQRLALKTERPDFVGNMQRNEKTFSFDNMKANSSLLIIAGSETTATLLSGVTYHLLRNPNKLNKVIDEVRTTFAKPEDITMASAGTLDYMLACLNEALRMYPPAPVGLPRIVPEGGDMIAGKWVSGGTIVSVCHYASYHSATNFRNPECFVPERFCGDEMYADDNRSVFNPFSTGPRNCIGKNLAYAEMRLILSKLLFNFDLELADKERDWLDQKTYSLWEKQELNVKLKKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4V3</accession>
    <name>A0A194X4V3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-type cation exchange, alpha subunit of ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_587961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069561.1">
        <property type="nucleotide sequence ID" value="XM_018209454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4V3"/>
    <dbReference type="GeneID" id="28819180"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587961"/>
    <dbReference type="InParanoid" id="A0A194X4V3"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000061">
        <property type="entry name" value="Potassium-transporting ATPase alpha chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ15206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125368" checksum="CE89C9E6BDAAAAE3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5C4</accession>
    <name>A0A194X5C4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_620271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069367.1">
        <property type="nucleotide sequence ID" value="XM_018210907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5C4"/>
    <dbReference type="GeneID" id="28820633"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620271"/>
    <dbReference type="InParanoid" id="A0A194X5C4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267859" evidence="7">
        <location>
            <begin position="18"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="151"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="362"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="590" mass="65272" checksum="27B4A4DB815F362A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5K7</accession>
    <name>A0A194X5K7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_720488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069447.1">
        <property type="nucleotide sequence ID" value="XM_018218573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5K7"/>
    <dbReference type="STRING" id="149040.A0A194X5K7"/>
    <dbReference type="GeneID" id="28828299"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720488"/>
    <dbReference type="InParanoid" id="A0A194X5K7"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="615" mass="69813" checksum="5D02656E506B3BFD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5S1</accession>
    <name>A0A194X5S1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069779.1">
        <property type="nucleotide sequence ID" value="XM_018215225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5S1"/>
    <dbReference type="GeneID" id="28824951"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686177"/>
    <dbReference type="InParanoid" id="A0A194X5S1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267930" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8053" checksum="01A1589782770462" modified="2016-10-05" version="1">MHAHTTCTSSTHRTILLLLLADAAAYPRTICTFERTLTSEDSVSSLSWAHSVLFVSISEASLRTMRSANSPAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X620</accession>
    <name>A0A194X620_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_782914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069986.1">
        <property type="nucleotide sequence ID" value="XM_018222626.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_782914"/>
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    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="49"/>
            <end position="64"/>
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    </feature>
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        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="569" mass="63794" checksum="AC9903C95C0A57A7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6C3</accession>
    <name>A0A194X6C3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_697808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216931.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194X6C3"/>
    <dbReference type="GeneID" id="28826657"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697808"/>
    <dbReference type="InParanoid" id="A0A194X6C3"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
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    </dbReference>
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        <property type="entry name" value="WKF"/>
    </dbReference>
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        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="474"/>
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            <begin position="115"/>
            <end position="127"/>
        </location>
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            <end position="166"/>
        </location>
    </feature>
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        <location>
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            <end position="392"/>
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            <begin position="393"/>
            <end position="410"/>
        </location>
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        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="51862" checksum="0F104B15F28F9521" modified="2016-10-05" version="1">MPSATGPNASAHVPAWKRLGLKLKSAQEPEQPAGDAIIEPDTSKRKRLATTTDNAPIKKSKRSADLSVQVGSEVAPVTPQLTRKKSVTFTPETKAEDGDSIKQLFNSWVAEQKSADPSFQFKNSSPAFKTPDTPRVEEDVDPNLDEKERRVKRVKKPKAEKAEKSKQPKKPAKITKPAAHFSRPFLQYLKEYCESRSTWKFNKNHQNHLLRHAFDADVVPSDHALYLFEYVRGLQGGVRTRLRDTALGIKVKDQEDGIAGFPSTMADTEKRQRDYDVAMKEYVATMTAAQTPASMGYEEGVELGLSDKAMAGRVAKRMRAERILAELASSPGKDENGAVLVSHEDKSKRLRLDDGSVLKVARKRKQRTITDVDSSSSESESDDESEDDEVEGAEGAADTSSSSSSSSSESESGEGDSEGDSEDGSEEDGSEESTLARRPTFSIPPTSGHQITSHSSQPNKTTICTSHNPMLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7I9</accession>
    <name>A0A194X7I9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_75320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070481.1">
        <property type="nucleotide sequence ID" value="XM_018221265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7I9"/>
    <dbReference type="GeneID" id="28830991"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_75320"/>
    <dbReference type="InParanoid" id="A0A194X7I9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
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        </location>
    </feature>
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        <location>
            <begin position="319"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="337"/>
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        </location>
    </feature>
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        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="36771" checksum="732A69F0BDD97D19" modified="2016-10-05" version="1">MRICQRVFPISILIMGIPSWFTLPRFLTWNAVPPGWNPINRLPPCGPDGPSPRPAAMSSSNEALPLLSSEVAATMDEPSPSALANAFSSMNLSPVPSSVAVATPKTPSLAQEAVAATSILAESALPINPASSQILPAASSEIPQVVPAASSGVEAFNVPVSSQIEDVLQPSTIGESISPLATPQVPDAPPTTSNPPVIVNLPGSASVAEILPSALAQSENLSPPASSLVQDFMPSASNSPNSLPAQTIEAARPTEAIVSSSPESSVMIPIPQAQAGDLAATIVGNFSTPATTLEDTSETTSQDPSKETLARVSPLYQNQTIHSSNATMPSNGTGHNSTITATTKSSSIPNSGSTDTSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8T7</accession>
    <name>A0A194X8T7_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_617265</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070552.1">
        <property type="nucleotide sequence ID" value="XM_018210795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8T7"/>
    <dbReference type="FunCoup" id="A0A194X8T7">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8T7"/>
    <dbReference type="GeneID" id="28820521"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_617265"/>
    <dbReference type="InParanoid" id="A0A194X8T7"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="548"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="671" mass="73760" checksum="CB9D782D0CA21796" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA48</accession>
    <name>A0A194XA48_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_69875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071369.1">
        <property type="nucleotide sequence ID" value="XM_018217005.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XA48"/>
    <dbReference type="GeneID" id="28826731"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_69875"/>
    <dbReference type="InParanoid" id="A0A194XA48"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="360"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1305" mass="148157" checksum="D969F587F6C2C5B3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAL5</accession>
    <name>A0A194XAL5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_646399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071566.1">
        <property type="nucleotide sequence ID" value="XM_018211923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAL5"/>
    <dbReference type="FunCoup" id="A0A194XAL5">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XAL5"/>
    <dbReference type="GeneID" id="28821649"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_646399"/>
    <dbReference type="InParanoid" id="A0A194XAL5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="889"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="629"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="756"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="926" mass="102973" checksum="3A8C14A240FA3146" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCB0</accession>
    <name>A0A194XCB0_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072154.1">
        <property type="nucleotide sequence ID" value="XM_018213065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCB0"/>
    <dbReference type="GeneID" id="28822791"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669086"/>
    <dbReference type="InParanoid" id="A0A194XCB0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="746" mass="81440" checksum="CBB0F5692EC4FE17" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCF1</accession>
    <name>A0A194XCF1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_696383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072208.1">
        <property type="nucleotide sequence ID" value="XM_018216832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCF1"/>
    <dbReference type="STRING" id="149040.A0A194XCF1"/>
    <dbReference type="GeneID" id="28826558"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696383"/>
    <dbReference type="InParanoid" id="A0A194XCF1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="71"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="280"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="710"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ17853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="752" mass="83222" checksum="C81640429983E0BD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD19</accession>
    <name>A0A194XD19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_684006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072423.1">
        <property type="nucleotide sequence ID" value="XM_018214797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD19"/>
    <dbReference type="FunCoup" id="A0A194XD19">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD19"/>
    <dbReference type="GeneID" id="28824523"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684006"/>
    <dbReference type="InParanoid" id="A0A194XD19"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="437" mass="49001" checksum="6FAB570D5E3BEDF0" modified="2016-10-05" version="1">MSFKGFQKSVIRAPQTFKAKFNIGEHTKDAVYIDAERRFQELETETKKLHDESKKYFDAINGMMTHQIEFSQAIAEIYKPISGRVSDPDSIVQEGNPEGIRACEEYEAIVKDLLATLQPELEMIETRVIRPADELLEVVKVIRKTATKRQHKQLDYDRHRATLKKLQDKKDKSLKDEKAMYKAENDVEQATQEFNYFNDLLKDELPKLFQLEREFIRPLFQSFYYMQLNVFYTLHEKMQGCDIGYFNLQLDVEEGFEAKRGDIQSQAEALSIVKFKTTGAKRPPGRLGAPNSRLAIESGKSSPLSPKAITAGPSSRHSISNDDEKPPPPYSTGLTPGSGETTVARANSTGAAWGAAAKAKGAAPPPPKPKPSRLSGAPAAETVTALYDYEAQAEGDLSFTTGEVIEIVTRTNNENEWWIGKIKGRQGQFPGNYVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD71</accession>
    <name>A0A194XD71_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_59944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072057.1">
        <property type="nucleotide sequence ID" value="XM_018210094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD71"/>
    <dbReference type="GeneID" id="28819820"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_59944"/>
    <dbReference type="InParanoid" id="A0A194XD71"/>
    <dbReference type="OrthoDB" id="4367792at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35522" checksum="FAEB5EDAAAC05909" modified="2016-10-05" version="1">MHLPATKRPESSNLFDKRSQEVSTCGMGRKISAAWSAISDQRERRKAQNRLSQRKKRQRDTQKHYTESNILQDVNGLENRCHGFSSTFNDTPLDEWLDCDQIDLEISEPSFTFHIPDDHLSFPEPLDPLDSNNQTFDLSLYQPICSNFDSDNDALISTIGPEEIFNWFETRYPDVERAAASSPLSAPGECTSFTPWSSSLVLVDSESLSAADYAFQEHGLAPSPTAPLNERLEFLLSIAQHIGFSSLDEVLLSYYTGRFDTPPAFREAQCRDLSNLLTHPLQTSHQCSGWESDGVQEESDAVEFVHQAVDNHEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD96</accession>
    <name>A0A194XD96_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_684087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072505.1">
        <property type="nucleotide sequence ID" value="XM_018214810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD96"/>
    <dbReference type="FunCoup" id="A0A194XD96">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD96"/>
    <dbReference type="GeneID" id="28824536"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684087"/>
    <dbReference type="InParanoid" id="A0A194XD96"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="47119" checksum="138B0ED209C1FC98" modified="2016-10-05" version="1">MCGRYALALRPSQVMRYLQDENMQVDEAPDDEGDGAPRQSYNFAPGYHGIVYRADVPDYGAGPRHHKKGEGEPEEEEASADTATEQDQGEVRYKLQSMKWGLIPFWTKRNPDYGSMMKTINCRDDSLIENKGMWNTMKQRKRCIVVAQGFYEWLKKGKEKIAHFTKRKDGQLMYFAGLWDCVQYEGSDEKLYTYTIITTDSNKQLKFLHDRMPVILENGSEDIRTWLDPKRHTWSKELQKLLRPSDAELECYPVSKEVGKVGNNSPNFIIPVASSENKSNIANFFAKGAAKSDSNASFASKPKDESPKKEKPSPQIKKEDGEDRKTIDHDGSEDHAPLPIPKEEVKQGIKRELDDIPDAEEQPKKVSRTSVSPSKPSPSPTKPTRKTRSATSNNTASPSKPSSKDKGSQKITSFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDE0</accession>
    <name>A0A194XDE0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_684128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072550.1">
        <property type="nucleotide sequence ID" value="XM_018214820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDE0"/>
    <dbReference type="FunCoup" id="A0A194XDE0">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDE0"/>
    <dbReference type="GeneID" id="28824546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684128"/>
    <dbReference type="InParanoid" id="A0A194XDE0"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ18195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="753" mass="81536" checksum="82D534C8CB2DDCC8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEA6</accession>
    <name>A0A194XEA6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_642803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072831.1">
        <property type="nucleotide sequence ID" value="XM_018211770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEA6"/>
    <dbReference type="STRING" id="149040.A0A194XEA6"/>
    <dbReference type="GeneID" id="28821496"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642803"/>
    <dbReference type="InParanoid" id="A0A194XEA6"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="504" mass="57554" checksum="C345ABFF7CA76646" modified="2016-10-05" version="1">MEAPMQLLSWRFIPVAVIVYFGTLVSYRLLLHPLARFPGPRLAAVTRLYEAYFDVVLNGQYTFKIVQMHKEYGPIVRISPYELHVIDSTFFEKLYRQEGRWDKYAWAYNGFSANGATICTADHDLHKARRMPLSPFFSKTKVAQQQDLIRQKVEQLCKRISQFSTSKKAIDLGAATSAFTRDVSTDFILARNYKSLDHEDFNAGMTNVFQDSGHIWRITKHITWFGPTMKSIPIDWIMRVADEGTKSFFRYLQDSTKDTEALLTATASPSSNLDAKTRRTIVHEIMDSKLTPADKSFPRVFDDVATVTGAGFETTASVLRLIFYHVFSNAEILQRLRSELRPATTNDLKVLEQLPYLTSVLMEGMRLSPAIASRMARIAPDRELVYNGWHIPAGTPIGMTTLLMHTDEMLYPDPMQFNPDRWMDLDFRKKADKTYAPFSKGTRICLGMHLAWAEMYLVLPALVQQFNFQFDGTIAEDFVCESDQFIIGTKGKGSLKAFVTLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEG7</accession>
    <name>A0A194XEG7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-DNL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_683515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072923.1">
        <property type="nucleotide sequence ID" value="XM_018214718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEG7"/>
    <dbReference type="STRING" id="149040.A0A194XEG7"/>
    <dbReference type="GeneID" id="28824444"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683515"/>
    <dbReference type="InParanoid" id="A0A194XEG7"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="198" mass="21824" checksum="0336BDC19DA8171E" modified="2016-10-05" version="1">MSLSTISSAAFRSMTRVSRPTSKFIPLSTRRPGQISRLQPLSNRFFSSEPPPSANTPAPTPEPRPAHAPPLPKQTSNTNTTYPFPSKPEYEMTFTCKPCSTRSSHRVSKQGYHYGSVLITCPECRNRHVISDHLNIFGDKHMTIEDLMREQGQLVKRGTLSEDGNVEFWVDGSVTKRGEGAGDAVTVKDSAEETAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEX7</accession>
    <name>A0A194XEX7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_780753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073100.1">
        <property type="nucleotide sequence ID" value="XM_018222413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEX7"/>
    <dbReference type="STRING" id="149040.A0A194XEX7"/>
    <dbReference type="GeneID" id="28832139"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780753"/>
    <dbReference type="InParanoid" id="A0A194XEX7"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="42932" checksum="69CC7421489B7389" modified="2016-10-05" version="1">MNASSTVEEKFDVLVRRQQFLNQDGKQAIKEILRTKKKAKIFWGTAPTGKPHIGYLVPLAKIVDFLRAGLDVTVLYADIYSFLINYLHPQPRELVEHRRRYYHLLVTAILQSLGVQTSRIHFVQESSYAYTKSFVSDFSRCCSLMTQQDTPDTMDEEGRTKTLSPLLCCVHQYLADIHLDTDIQFGGEDQRPIFQHASKIIPQLGYRKRQYLMNAMAPGLKGGKMSSSDPASAKIEFLDDARTVTDKIMEIPIGESHGGYSTDNAVLGILRTILIPLSELRLEHHKDEFANDAFVSADAPEGTLFTIEVAIWCFGECVRKHYKSYDEIEEDFRCWRMGEEDLKLAVARSLNCVLEPVRRRLGSSEEWKELELLAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFS6</accession>
    <name>A0A194XFS6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_581780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073405.1">
        <property type="nucleotide sequence ID" value="XM_018209125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFS6"/>
    <dbReference type="FunCoup" id="A0A194XFS6">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFS6"/>
    <dbReference type="GeneID" id="28818851"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581780"/>
    <dbReference type="InParanoid" id="A0A194XFS6"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042998">
        <property type="term" value="P:positive regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000035">
        <property type="entry name" value="Phosphatidylinositol 4-kinase PIK1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <end position="461"/>
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        </source>
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            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="52113" checksum="2D8D234F94C6ACFB" modified="2016-10-05" version="1">MLYPESMFSLGFSVLDTEEPSYIVRLPLLEDTTNIPWIFSTQDPSNAKLAFELFRTNPDANNGREVIGCGMALLASLKQAFGMKRESLHRHFTIPIVSNTTSEYLGAVTFSFIVSHPLALPDTPPISISDLWSENCPTKVVGHRGQGQNMLAAKNLQVGENTIQSFLSAVQLGTSYVELDHMPVIYHDFLVCETGVDSPMHTLTYEQFMRISVEQSDQSLNAPPAIVETECFKTPMRRKTRTRSLNACDNALTEAFMARVKHTFDFSTRGYQANTRGAFIHEAFITLEELLTTLPDTIAMDIEIKYPMLSEAEDDWKMDPYFIEANFFVDSILLCLAKHISTRSIFLCCFSPEICILLSLKQARWPIVFGNDSGNWQPSDIRAKNLQEGIHFAKAWNIDGLALASQPLIFAPKLVGFVKQRGLVCASYGAMNDEPEGVKIQAEAGVDILIVNKISMAAKIIATLEDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHA1</accession>
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    </protein>
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    </gene>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="APC_YAT"/>
    </dbReference>
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        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19504.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="579" mass="64488" checksum="9A89AD9003E3B5D4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHH6</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208349.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28818075"/>
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    <dbReference type="InParanoid" id="A0A194XHH6"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
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        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="695"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="695" mass="77616" checksum="4859FDDBDF136200" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI68</accession>
    <name>A0A194XI68_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
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        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
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        </reaction>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28832053"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779802"/>
    <dbReference type="InParanoid" id="A0A194XI68"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268326" description="alpha-galactosidase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="80"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="38132" checksum="094811BBA03FCC00" modified="2016-10-05" version="1">MNLPSILLAALLSSSLTTALNLRKRYDEAPFKPTKCAVKAKVTQTAACPISGLPDSTGGITLTIAPEPTSWSKPSPSSLFQVVLQNNTEVRASVDDGIDVYDIDIDSSAATFASLIGAGKYVVCYFSAGTMETWRSDFGCFNHNLGAQDLGCDVGGPWANEFWVNTSSTEVRKIMQARIQRAADLGCSAIDPDNMDGYGNQNGIGATEEDSISYVKFLSREARSRGMGISLKNALEILPNVTSDVDFGVNEQCNEYDECDSYTPFWALPTPLPVFNIEYPPHNKDNWTEKYAEKSCDESLDWGYPYMFTDLKNYPTVTCAVSRCTEDGPSPAVPNGGLVIPSGCVDGMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XID1</accession>
    <name>A0A194XID1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase I associated factor, A49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_682721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074239.1">
        <property type="nucleotide sequence ID" value="XM_018214555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XID1"/>
    <dbReference type="FunCoup" id="A0A194XID1">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XID1"/>
    <dbReference type="GeneID" id="28824281"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682721"/>
    <dbReference type="InParanoid" id="A0A194XID1"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="49831" checksum="728B0ACAB930F3A6" modified="2016-10-05" version="1">MADKVEKVKKRKRHIDDSSKPSKRVAIDEDKQISVSLLETGKWAPVLASTPGLAMPSEINLRAYTKMRRNAPSRVGKSGDIATKELILHSSDHSKLDYTAREEEVGGVDSLLKHYIGVYDPETGKMEVVEARKMIVRGSVRAHQATKEDDLSMNMRERRNELGQTFGTKKARKAIASVTENAISPDKSLRMLANGQAPKLDGASAAIIASMAKATKGMSTRDDLSKAADDAKPRPKANLDATDVADVYTVDSLIGEDTMMLIPVRLWQEAIRKNKEIVISSSYVANRIGRTKYDNIEKLKILRYMLLLIDVYNNCTIMRGQRKLPNPRTLREVIGDMPEAVLEGVKRNFTEGGLMSKYKSDLLITHLCAMACLVDNFEVDMWDLKEDLKLEMKPMAQYFNEIGARNGALGVAEKQRLGLDKAAAAQRKVAKLKLPLDFPKVGFGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ69</accession>
    <name>A0A194XJ69_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_461439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074152.1">
        <property type="nucleotide sequence ID" value="XM_018207687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ69"/>
    <dbReference type="FunCoup" id="A0A194XJ69">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJ69"/>
    <dbReference type="GeneID" id="28817413"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_461439"/>
    <dbReference type="InParanoid" id="A0A194XJ69"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112682" checksum="BDE2A60FD3AD668A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJG9</accession>
    <name>A0A194XJG9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_639705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074653.1">
        <property type="nucleotide sequence ID" value="XM_018211632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJG9"/>
    <dbReference type="GeneID" id="28821358"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639705"/>
    <dbReference type="InParanoid" id="A0A194XJG9"/>
    <dbReference type="OrthoDB" id="4500971at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268312" description="Hydrophobin" evidence="3">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13100" checksum="13BB4954FB90CC08" modified="2016-10-05" version="1">MKTSVLSVIALGGLFNTAFASPVHPRDMSVCNAISQRQCCDVGVDGIINLTCAAPSRTPTDMKDFSELCSENGQQAACCVLPFVSILRPTFEGRRANCLHSLGMDLCAGNHRRDQARSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJR8</accession>
    <name>A0A194XJR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbohydrate esterase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_610504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074753.1">
        <property type="nucleotide sequence ID" value="XM_018210549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJR8"/>
    <dbReference type="FunCoup" id="A0A194XJR8">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJR8"/>
    <dbReference type="GeneID" id="28820275"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_610504"/>
    <dbReference type="InParanoid" id="A0A194XJR8"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268388" evidence="9">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="256"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="476" mass="50298" checksum="A29D5F7403CB2066" modified="2016-10-05" version="1">MQLFSSTIVLLLCSSSVSAGPLDRLFGRVTSRQLVSVRTVSPDNTCGTIFNSTNNGTTANGYTCPSDLPCCSVHGFCGSTNDYCLTTAGCQSLFGNCTAPSAGTITPDETCGILGAGQYGYTCDAQSPCCSGNGWCGNTTDYCSPSNGCQTAYGTCDAASNSTSSSGGSSGTPGTSTNGQCGPGFGTCASNECCSLAGYCGVTEDYCEAPDCQFNYGPACDANKIPSGTNTSSIARPKLGSVMYGSAGIYDCANAGDMALTFDDGPFIYTSHILDLLDQYNASATFFITGNNNGKGEIDNTSLPWSALIQRMYNEGHQVASHTWSHPDLCNITSDQRKNEMYKNEMALRNILGVIPTYMRPPYSSCTAECGCEADLKELGYHITYFDLDTQDYLNDSPTLIVNSETIFDNAIANSSSTTDDFLVIAHDIHNQTSQVLVEYMLKGLTTAGYKPVTVGTCLGDSKANWYRTDTTATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKC0</accession>
    <name>A0A194XKC0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_437354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074592.1">
        <property type="nucleotide sequence ID" value="XM_018207520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKC0"/>
    <dbReference type="GeneID" id="28817246"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_437354"/>
    <dbReference type="InParanoid" id="A0A194XKC0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="20887" checksum="213B5C9641C231B3" modified="2016-10-05" version="1">MRMYLPGGYFSRYSGLLLSNRRALLLRPPQFRSTPPSTIHHPSHRPNYHDHHHQNESAKSVLPSPLLPHDFDPSRRPPRVLTQHSDIRTPRPLTNPRTSRTLSSTWSDTPQGPLSIPPEFDRVCIAPHYSRIFLPFESEVTRFDDSNSLALTLHHHSDRPSSFSAHGPGDPNLSLGQAAIVSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKL1</accession>
    <name>A0A194XKL1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_440735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074682.1">
        <property type="nucleotide sequence ID" value="XM_018207538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKL1"/>
    <dbReference type="FunCoup" id="A0A194XKL1">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKL1"/>
    <dbReference type="GeneID" id="28817264"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_440735"/>
    <dbReference type="InParanoid" id="A0A194XKL1"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="597" mass="66033" checksum="872F7A6E04169F29" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKM5</accession>
    <name>A0A194XKM5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_682452</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075120.1">
        <property type="nucleotide sequence ID" value="XM_018214514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKM5"/>
    <dbReference type="STRING" id="149040.A0A194XKM5"/>
    <dbReference type="GeneID" id="28824240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682452"/>
    <dbReference type="InParanoid" id="A0A194XKM5"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="140"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ20765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="48060" checksum="8BD3C78FDCE62480" modified="2016-10-05" version="1" fragment="single">MSPLKSWLPIPPKSDFSLANIPFGIITSRNSQTQHRPATAIGDHVLDLLAFSRGNGFSKLPSLAPHLSVFEQPTLNDFAALGRPVHREVRKYIQDVFADNTPYPGILKDNEELRKNALLPKQDTKTHLPMQIGDYSDFFAGRNHAVNLGSMFRDPKNALQPNYNHLPVGYHGRASSVVVTGTPITRPHGQILLDPSQPSSPTFAPCRFLDIELELACFLCKSNPLGQPVRIRDAEEYIFGYVLMNDWSARDIQRFEYVPLGPFTAKSFATTVSAWVVLPEALEPFRAEKLRNEKEGEVAKYLREGREDTVYDIGLEVELTTPDGGTTTISRVSGKNLLWSFPQMVAHHSVGGCNMRVGDLLGSGTISGTKEDGSEFGSMIEMNQQGKREIMLSGMDVRKFLKDGDTITIRGTCGGEEGALVGFGECSGTIESAIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKP5</accession>
    <name>A0A194XKP5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_705512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075034.1">
        <property type="nucleotide sequence ID" value="XM_018217456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKP5"/>
    <dbReference type="GeneID" id="28827182"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705512"/>
    <dbReference type="InParanoid" id="A0A194XKP5"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="52"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ20679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="60731" checksum="34BD244150330FC9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLB3</accession>
    <name>A0A194XLB3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_681599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075323.1">
        <property type="nucleotide sequence ID" value="XM_018214330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLB3"/>
    <dbReference type="FunCoup" id="A0A194XLB3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLB3"/>
    <dbReference type="GeneID" id="28824056"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681599"/>
    <dbReference type="InParanoid" id="A0A194XLB3"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="183" mass="20277" checksum="FFA9B5CAD5E6478E" modified="2016-10-05" version="1">MPDLSIFKSPAPYHIIAYGTLLGTEFFQTFVGGIVSYQALPRPQFSQLQQKLFPVYFGLQTTLPAILALTYPGSRTSLGPSSGISGTFADVNRWTVLAPIATIFVTSAVNMLYCGPETTRIMRKRKVQETRDGKKYHDPAPQSTEMQQLNKAFAWMHGASSLVNLVGYIATIWYGFSLAERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLD8</accession>
    <name>A0A194XLD8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_681627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075348.1">
        <property type="nucleotide sequence ID" value="XM_018214338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLD8"/>
    <dbReference type="STRING" id="149040.A0A194XLD8"/>
    <dbReference type="GeneID" id="28824064"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681627"/>
    <dbReference type="InParanoid" id="A0A194XLD8"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="29734" checksum="459D4B5C0D2119F9" modified="2016-10-05" version="1" fragment="single">MGHEFTGTVKDIGSQVKSVKVGDRVVSPFTVSCGECFYCLDDFSSRCTKNQLFGSPSLDGGQAEFVRVPLADGTVVKAPNSIPDRALILMADIFPTGFFGAKNAFKFLTPKQITNSVAVVIGCGPVGLCAVISALSFKPKKVFAVDSVESRLELARKLGAEPLNFAKDREGMERRVLEETEGRGADLVIEVVGLSPALKTAYDLVRPFGIISSIGVHNGEIPWSGAQGYDKNLRIQMGRCPVRSVYPEALQLFEQKQDLFGFMFEKIMPLSEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM52</accession>
    <name>A0A194XM52_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_428227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075519.1">
        <property type="nucleotide sequence ID" value="XM_018207454.1"/>
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    <dbReference type="OrthoDB" id="2308815at2759"/>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
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        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
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        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="577" mass="63783" checksum="6308764E90141A3C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMB2</accession>
    <name>A0A194XMB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative altered inheritance of mitochondria protein 18, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_681813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075584.1">
        <property type="nucleotide sequence ID" value="XM_018214377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMB2"/>
    <dbReference type="FunCoup" id="A0A194XMB2">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XMB2"/>
    <dbReference type="GeneID" id="28824103"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681813"/>
    <dbReference type="InParanoid" id="A0A194XMB2"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
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        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
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        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="394" mass="44041" checksum="9113B3845C35F78D" modified="2016-10-05" version="1">MSLRNPTIRLLRTHIPRPRILRPISQFLPRYSSTRELPSQSNHVEPPPALDPITLHRLEAEHRAYQQRRTYYLSAGVVLGMLAIWITATSIDLETYPPASKLDSGRRSDDPLVVLGRERKVVVQKLGEEPEEKVEIVATGTSYVPTFPRIVLFVDDEREIIGNGAGPAVSDDRLVEYQLLGLGIRTVSFLGVQVYVVGMYVATDDIAALQEALIKKIDPIASTLVAGEKEKLREKLYDPEEGTRIWSEVLRDAGVRSLMRIVPTRNTDFPHLRDGWVRAITARAQGNRAEFGDEAFGKSVADFKALFNRGTVPKQKELLLSRDKQGKLAVWYDDGKVGANRLGDVADERLSRALWLNYLAGKTVASEPARKSIIDGIMEYVERPVGTVATQVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMU1</accession>
    <name>A0A194XMU1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_714673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075935.1">
        <property type="nucleotide sequence ID" value="XM_018218144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMU1"/>
    <dbReference type="FunCoup" id="A0A194XMU1">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="GeneID" id="28827870"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714673"/>
    <dbReference type="InParanoid" id="A0A194XMU1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="548" mass="62288" checksum="558150AAE688C112" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMU4</accession>
    <name>A0A194XMU4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_578121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075452.1">
        <property type="nucleotide sequence ID" value="XM_018208927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMU4"/>
    <dbReference type="STRING" id="149040.A0A194XMU4"/>
    <dbReference type="GeneID" id="28818653"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578121"/>
    <dbReference type="InParanoid" id="A0A194XMU4"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="288" mass="32907" checksum="5563F44EAA5C8D36" modified="2016-10-05" version="1">MDLLEAYHNLFLIYYSEEPNFNTCDIEIALEQVELLITVAGLYSSIVVTRPYIISCLFSFGRELSRAIARDPPRWVKVAILIASPTIFTEGVVHIVGKAPSWPWSSTKREELGAKVENFLDKKADELEALRKGMERTLFLTSIRINGKEVHLDKDNESTRNTWFVVQIWRDWYSRSLSQAAHSTNKSQSMAKIYRSIAKGGDTYLPLEEVLDLLAAFRHTKDHDTNFDVREVAMDLRRMKVFASQIVKPLCINNSMLDVDAEGIGHFTCVEVKDHEWAQLETLGLDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNI6</accession>
    <name>A0A194XNI6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2Fe-2S ferredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_576667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076024.1">
        <property type="nucleotide sequence ID" value="XM_018208849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNI6"/>
    <dbReference type="STRING" id="149040.A0A194XNI6"/>
    <dbReference type="GeneID" id="28818575"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576667"/>
    <dbReference type="InParanoid" id="A0A194XNI6"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="112" mass="12140" checksum="0B64661AF6B6F368" modified="2016-10-05" version="1" fragment="single">RRAIFFTDSNGKRHACKAIDGESVLDVAKSYNLEVEGACQGDCACSTCHVIVTSKLHYDALDSPTEREEDMLDLAFGLTVTSRLGCQIHMAPALDGIELKLPGIIQEKSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP60</accession>
    <name>A0A194XP60_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PROCN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_778319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076328.1">
        <property type="nucleotide sequence ID" value="XM_018222199.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XP60">
        <property type="interactions" value="1355"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP60"/>
    <dbReference type="GeneID" id="28831925"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778319"/>
    <dbReference type="InParanoid" id="A0A194XP60"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2128"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ21973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2360" mass="274098" checksum="46552E25E05AB36B" modified="2016-10-05" version="1"> </sequence>
</entry>
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    <accession>A0A194XP73</accession>
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        </submittedName>
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        <name evidence="3" type="ORF">LY89DRAFT_681252</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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    <dbReference type="InParanoid" id="A0A194XP73"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="800"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
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            <end position="660"/>
        </location>
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        <location>
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            <end position="173"/>
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        <location>
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            <end position="217"/>
        </location>
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        <location>
            <begin position="255"/>
            <end position="280"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="822" mass="93271" checksum="A650197BF0169EB1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217364.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28827090"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704202"/>
    <dbReference type="InParanoid" id="A0A194XQF0"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="384"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
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        <ligand>
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        </ligand>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR30</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR30"/>
    <dbReference type="GeneID" id="28818484"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574779"/>
    <dbReference type="InParanoid" id="A0A194XR30"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="578" mass="65215" checksum="8193AE4C702F270C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR54</accession>
    <name>A0A194XR54_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_302772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076889.1">
        <property type="nucleotide sequence ID" value="XM_018206581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR54"/>
    <dbReference type="GeneID" id="28816307"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_302772"/>
    <dbReference type="InParanoid" id="A0A194XR54"/>
    <dbReference type="OrthoDB" id="3562088at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013153468" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="224"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="309" mass="31843" checksum="8389C52ECD123C22" modified="2016-10-05" version="1">MKFTALFLAVGFASAIPQPLPASWSNTGEKGSEIQELFKHVSPLQGNDLEARSLPTCHHDNLFRIFLDHRYSSSASAFCSTYITSTMVSTIVPLTTTTITAMETAATAFSTVIVLATATSTTLAPDAIITVAPKAKRQALAGCPGKAGTYPPARISSACSCLVTPALMISTTTTAALSTVTIASTIQITAAATITETSTTVLDVAGPAAATSTIIGSPAPASYCSAGTMFDPNNDAFTVHCATSYASGGATLYSTITAISYQDCLNSCGANVKCRAFSYLLTVSSNNCYLYGKGLLTPSVDPTMDSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSZ0</accession>
    <name>A0A194XSZ0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_637154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077202.1">
        <property type="nucleotide sequence ID" value="XM_018211518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSZ0"/>
    <dbReference type="FunCoup" id="A0A194XSZ0">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSZ0"/>
    <dbReference type="GeneID" id="28821244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637154"/>
    <dbReference type="InParanoid" id="A0A194XSZ0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ22847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="413" mass="45620" checksum="0BDF94CED9C9F1BF" modified="2016-10-05" version="1">MGQYFHDLLYTLTNCMSCFPGSPQLKINNRSFKILRLLGEGGFSYVYLVQDTGNEAQYALKKIRCPFGQESVAQALKEVEAYNLFSPNPNIIASVDHCVMADRSDPGAKTVYILLPYYRRGNLQDIINANLVNHTKFPEKRLMILFLGVCKALKAMHYYKVAGGPGGARSLQNARKIRGQAARADQDAEEEVEQRRGRQKGRELDPDSEQQEPLMDNEVTQSQEGVAPGEIRAYAHRDIKPGNIMIDDDGEQPILMDLGSLAPSPTPITSRSLALAVQDQAAEHSTMPYRAPELFDVKTGSTIDTKVDIWSLGCTLYACLVGKSPFEMRSDETGGSLSLCVLGGDWRFPDEGAGGKKKATNQPGQTEDSEIHESIREVVRKCLKVEAAERPDVNELIEIVEAVIAELPEDGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT62</accession>
    <name>A0A194XT62_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein-ER retention protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_637222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077242.1">
        <property type="nucleotide sequence ID" value="XM_018211519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT62"/>
    <dbReference type="FunCoup" id="A0A194XT62">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="GeneID" id="28821245"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637222"/>
    <dbReference type="InParanoid" id="A0A194XT62"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="191"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="454" mass="50808" checksum="6FCC8B17108CE618" modified="2016-10-05" version="1">MDGDPAVEPELDSFSLTLPLPYRVALVVVLGVWAWGANLHFLSLLKIDVPALLHYPPRTSPRTDPPHHLSTYRLASLLTIPLALSLFLFWILSHRNPTLVIYYDFLPISYLCVLLGLFLLPLRRFSSSGRTRFLTTLQRVSIGGLAQAHDGKFGDILLADVLTSYAKIIADLFVSLCMFFRPDGSATRRPDRGCGGQYLVPIIIAIPSLIRLRQCLIEYVRVRALNARNGGTIGHHGWGGQHLANALKYASAFPVILFSALQRNLSMNHANIGLTEVSLYRCWVIAVFVNSFYSFYWDVAKDWDLTLFSSLWSRIHPSSRTAYTPLNSHSSSSSTSASHPQTNQPFGLRPRLYLVSSTVYYTVITLDLLLRCTWSLKLSPHLDHFADFESGIFLMEFLEVGRRWIWIFFRVETEWVRNTGSGGGSGSGGLLGMGMGIEDGVLLGDMYGKDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTJ4</accession>
    <name>A0A194XTJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077372.1">
        <property type="nucleotide sequence ID" value="XM_018213949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTJ4"/>
    <dbReference type="GeneID" id="28823675"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679837"/>
    <dbReference type="InParanoid" id="A0A194XTJ4"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="29271" checksum="3439CAF7CA56A7AD" modified="2016-10-05" version="1">MDLSLNLEGTHVLITGGTGFIGSATVDALLAAGANVTSLDLRPPPPTTTASSFSYISCDISSEDALTKAFALASEKHGPIACCIALASLDLSVLHHHESLADMVVEQWRRTHKINVEGTFLTARTWLRQLREYSKVDQAKELKNVSLIIVGSESGHFGERGNADYASGKSAVQGGFVRSLMGDVARIWPGARVNAVAPGPVDTPQFKNECAANPDQLWLDAQATVALKQPVPPESVAKSILFLASENWSGSITGQILNVDSGKQGKVMWMQKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU45</accession>
    <name>A0A194XU45_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_569466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078016.1">
        <property type="nucleotide sequence ID" value="XM_018208577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU45"/>
    <dbReference type="GeneID" id="28818303"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_569466"/>
    <dbReference type="InParanoid" id="A0A194XU45"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="65" mass="7321" checksum="7EA1895517204307" modified="2016-10-05" version="1" fragment="single">EADFFKQLSEDVAVAEEDTKAEANVVHGFGSYKSAVVPWLRRTGIEEHTRGLKKDEMHTSFTVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUJ6</accession>
    <name>A0A194XUJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_603888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078064.1">
        <property type="nucleotide sequence ID" value="XM_018210332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUJ6"/>
    <dbReference type="STRING" id="149040.A0A194XUJ6"/>
    <dbReference type="GeneID" id="28820058"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603888"/>
    <dbReference type="InParanoid" id="A0A194XUJ6"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="29467" checksum="64E9B657EAE41C9B" modified="2016-10-05" version="1">MSGRRDFQKEQLKALVFDLMGTCCDWHSSLLPSLQASPTLEQLPSSELSKFANDWRAGFFAEIHARFQARDPTEDIDITHRRLLDRLLSARGVDLKIWDEDVRQKLVDQWHFQIGWPDALPALSRLREKNFLVVLANGTTRLQLDIAKYSGLPFHALFSSQLLGLTKPDPAIYVKAMELMQLRPEECAIVAAHAYDLRAAKKLGMGTIYIQRATEDLDEDMTAIREEVDLFIDGTGGNVSSGLGELADMLGYGVSIHQSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUN9</accession>
    <name>A0A194XUN9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_1957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078109.1">
        <property type="nucleotide sequence ID" value="XM_018205740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUN9"/>
    <dbReference type="GeneID" id="28815466"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_1957"/>
    <dbReference type="InParanoid" id="A0A194XUN9"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="288" mass="32886" checksum="7A3AC067674873CB" modified="2016-10-05" version="1">MASLSTIAPNLGAFIVLPTEIRTRIYGLVLDFNWANYPSPQKNWTTSSQDLTAYLSSEDGQTDPPSKNRVSLLRTSKTIYEEAVIVLVQVNPFRIHIERGECQVWGVTHDEAKPENWDFNLFAEFPFRISYLELDPRDPFLRRGLFEKLRDLNLRLTLVEESDIFPIEKEENGVGMCELTPFMTLLAPMIKNLKEGALKRFIFTIVSKEKERGSVELVLDMIASFRGLTYASVNAFNSYRGREPGWRLKRDYKDHLVGAMKLPKGVAAPDWVPGDEESPDAFSIFEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUV5</accession>
    <name>A0A194XUV5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_573056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078174.1">
        <property type="nucleotide sequence ID" value="XM_018208672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUV5"/>
    <dbReference type="STRING" id="149040.A0A194XUV5"/>
    <dbReference type="GeneID" id="28818398"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_573056"/>
    <dbReference type="InParanoid" id="A0A194XUV5"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="170"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="618" mass="67442" checksum="C4331B300C553352" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1F5</accession>
    <name>A0A132B1F5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_603686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947451">
        <property type="protein sequence ID" value="KUJ06212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060567.1">
        <property type="nucleotide sequence ID" value="XM_018210317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1F5"/>
    <dbReference type="STRING" id="149040.A0A132B1F5"/>
    <dbReference type="GeneID" id="28820043"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603686"/>
    <dbReference type="InParanoid" id="A0A132B1F5"/>
    <dbReference type="OrthoDB" id="3202072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11126" checksum="724888ED7F74C9D7" modified="2016-05-11" version="1" fragment="single">TSEGKSLLFILPCILPNARVTILVLPLMSLRGDLLRRVRELGIDHLVEQQDAPLVFIIVKVAYTEQFRTYAHKLAATQDLGRIVFNEAYLTIIASDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1G4</accession>
    <name>A0A132B1G4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_603657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947450">
        <property type="protein sequence ID" value="KUJ06230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060585.1">
        <property type="nucleotide sequence ID" value="XM_018210314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1G4"/>
    <dbReference type="GeneID" id="28820040"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603657"/>
    <dbReference type="InParanoid" id="A0A132B1G4"/>
    <dbReference type="OrthoDB" id="3558117at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF159">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="112" mass="13055" checksum="1692E137E1B98D5B" modified="2016-05-11" version="1">MDHAGRLQCDWQTCFKSFYRNADLQRHYRIHTGDRPHLCPTPGCGKSFSQRSALTIHTRTHTGEKPYLCPQIGCGKGFADASRLTKHRWIHTGRRPYKCTQKRCLKRSVFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2I6</accession>
    <name>A0A132B2I6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_743744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060957.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2I6"/>
    <dbReference type="STRING" id="149040.A0A132B2I6"/>
    <dbReference type="GeneID" id="28830702"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743744"/>
    <dbReference type="InParanoid" id="A0A132B2I6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7043" checksum="1D264A96A5569EE7" modified="2016-05-11" version="1">MIAHGVATTLSNDDPAIEGQNDARLSYDYFEAVQAFDNVGFAGLGRRAQNSARYSNFLDQDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2V4</accession>
    <name>A0A132B2V4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_790642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060599.1">
        <property type="nucleotide sequence ID" value="XM_018223396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2V4"/>
    <dbReference type="GeneID" id="28833122"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790642"/>
    <dbReference type="InParanoid" id="A0A132B2V4"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17590" checksum="935DE25E7DAAE22D" modified="2016-05-11" version="1">MTFELEEAGTPDLEELGVVLGKAYINDPILSQLMPGVDQAIQDNFWTAWLRGDHKKPGEKLFKIVDTDTGKIVAFEKVRYPAKPAENGEEEHEAPPEGTNVELLMHWFEQMDLYQDKHMDFEKDCCKDSRHHSRPDLCRGRLGRRLGRRLGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B408</accession>
    <name>A0A132B408_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_369166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061503.1">
        <property type="nucleotide sequence ID" value="XM_018207047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B408"/>
    <dbReference type="STRING" id="149040.A0A132B408"/>
    <dbReference type="GeneID" id="28816773"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_369166"/>
    <dbReference type="InParanoid" id="A0A132B408"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="579" mass="64228" checksum="478A21A19FE9814D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B416</accession>
    <name>A0A132B416_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_789946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061510.1">
        <property type="nucleotide sequence ID" value="XM_018223312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B416"/>
    <dbReference type="GeneID" id="28833038"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789946"/>
    <dbReference type="InParanoid" id="A0A132B416"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="88"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="500" mass="55917" checksum="9695DEEF91B8DDC4" modified="2016-05-11" version="1">MPPLRTYGSKRSASARATAAAMFGQAEEDLAYAVGSLSLQPEEEEELTLENASIIPVPASLLPLVTAYKTDIGRPLLVQDWNDILDDHADVTKIAEASYAEVYRVNTAAGSSILKVMRIRMEEQPESMRCYTASDVKAIISEIRIMNALTTVPGFVTYKDAHLVQGMIPPCITKAYRKHVKALKRDGGWSHFPVPHTLPEETIYLVIELGDAGDVLDEVGLDTKEQVWDVFIGVTIALARAEVTNEFEHRDLHENNICVKLGPKRPVGDDNHDDANGPKYGSTGWEITLIDYGLSRTQLPNGEIAFNNLEDDLRLFGSQGFGIARVQYETYRRMRTYLILGTRTVKQAGWQKDFRFRDVKTPRSWSEFLPYTNVLWLRYLLLMLIRKLKDKHPSLAKNVEAEAKELKRQFEPMTKVENGAFSTAQDVLVWLVGAGWVTEEQISGEDGTSFLTMGEPETEAEVEGDNASGDNAEENVEEDAEEDGEEDGEEDAEEDLYSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4E1</accession>
    <name>A0A132B4E1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_766916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061458.1">
        <property type="nucleotide sequence ID" value="XM_018221738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4E1"/>
    <dbReference type="GeneID" id="28831464"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_766916"/>
    <dbReference type="InParanoid" id="A0A132B4E1"/>
    <dbReference type="OrthoDB" id="10558558at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="43552" checksum="8147B81C6D8FAF3D" modified="2016-05-11" version="1">MGLPTSFHRFSDLSTAIRDRIWALAAGEPLFPTSRRMIPLRVQMIPRLSTVSEEDIPGFDPEQDEFDGDGVYIRWHFRVFGPGPAAVNAALWHSSTDSYRFYLRRNPNYIQMRDHVFCSPWSLFVLWMYARERDPVWSSFDPNIGGLGPSEEQRGRDLVGFDRIRVLETSLPSNVQGLRDDMFLIRNIFTYRSPAGGRVRVAAGTAFSVARLYRRIDWVDAFRETIYQLLAPMRFATRTSDDPDMPNYYNSGLRAADGALEQDGQSAEMLPVDAWDEFDMNVRVFLAWSEEEESGNDTQSNNGSSNSGDSVVSYSGEIPSRDVIWLLFSFGRYVLGSHWVGSYPIVPPSVEELLRRAALDIAIRERGEEVRSEGVGVNMEGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4L4</accession>
    <name>A0A132B4L4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_692203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061209.1">
        <property type="nucleotide sequence ID" value="XM_018216487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4L4"/>
    <dbReference type="GeneID" id="28826213"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692203"/>
    <dbReference type="InParanoid" id="A0A132B4L4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="134" mass="15144" checksum="E85769BCA732F278" modified="2016-05-11" version="1">MEPRVFSSASASSLLGASAVRVQCGAGWRIQYSTNDRPRQPGDGDAGLMGFMGSWVHGLGCDGGTLTDWQWQWQWHWNENDRESMFVPMQGKARHRQVMSEEKREKGKGRIATTQSKHNTHRLTPQLMLIDAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4X6</accession>
    <name>A0A132B4X6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_661776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061082.1">
        <property type="nucleotide sequence ID" value="XM_018212619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4X6"/>
    <dbReference type="STRING" id="149040.A0A132B4X6"/>
    <dbReference type="GeneID" id="28822345"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661776"/>
    <dbReference type="InParanoid" id="A0A132B4X6"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF20">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ06727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="40583" checksum="831111658C03D75F" modified="2016-05-11" version="1">MELPEKNIPTRALVVEKPGSPFILQDVTLDEVRDNEVLVEMKYTGLCHTDIVVQQGLMPVGDYPAILGHEGAGIVRRIGRSVKDKSLIVGDEVLLSFSSCGNCSYCAQSQNGSCPHITAINFTGTRLADGSNPARLHDGTAVRSKFFGQSSFSKLAVVSETSILKCELSSEEFAIMAPMGCGYYTGAGTVMRVLRPKQETTFAILGMGAVGLSALMTAKAMGVQRVIAVDILDTKLDLAVSLGASDIINSGRITSISAAIKDLVSEGVNQILDTTGLGFLIEDGIRALGHGGTFALVGTPRPGQSIAIDPLDFFLSCKRIIGVIEAASNPVQVIPELVDLHRKGLFPIEKLSHLYSVNGLDQALVDLKAGTVVKPILSWESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5N4</accession>
    <name>A0A132B5N4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_742492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062075.1">
        <property type="nucleotide sequence ID" value="XM_018220827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5N4"/>
    <dbReference type="GeneID" id="28830553"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742492"/>
    <dbReference type="InParanoid" id="A0A132B5N4"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="36790" checksum="5FCCC6E81DBB9569" modified="2016-05-11" version="1">MSFSCFLLESLPHSRSQAQTESPAQMEDELHGTMHSTTPHHALDAPSNSTTTSTPQFQTLTSSPSSPLQTFHLFPLLPTELRLKIYTYALPPPTLHTISLPTCPSTCPIPSCPRQHAPRTLSSLPVLLHISHESRTECLRHYTVLSSPLGKGFHQAFDSRRDSVYFSNGRGPARDFWSVKAEWPACVEGGGKIRNLVIDEATLERGDFLKFGEEVLGLESVTVLLMPWSSIGKAGGGGELVRTFGGAEIGEEEVVRGNDRDWGLKELRREFLGWLEEKRVELGREKKPVVKVAQWGACLRGGDEEGFTNGGGQWKLVETGLWVHWEYNGNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6C0</accession>
    <name>A0A132B6C0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_766179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061904.1">
        <property type="nucleotide sequence ID" value="XM_018221716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6C0"/>
    <dbReference type="GeneID" id="28831442"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_766179"/>
    <dbReference type="InParanoid" id="A0A132B6C0"/>
    <dbReference type="OrthoDB" id="3561261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="38672" checksum="8B475711F5198953" modified="2016-05-11" version="1">MASKAKKVLKRMRKALSKAWRKLSRQSETEESPYIGPVAAVAPNAQAGTNYRRRVQPKPPTFHQFSRFPAELQKMIWEMAVPEPGILFMQSMPWTFQHCTFQHLLPETFADALPRPTAMLRVCSESSKAYKNAFPFEIPFAVCRRLGCDCGADRPHLRTTSSGHGILRFGIHDQLFVRNLGVLRGSLLDRCSLIQPTWATGVRNLMVSIDELVDDKVDALLSQHMPRFPSLDRVEAVDQVILRYQGLRLNRAGCQALVERTTTLRICLLKKNAVPAWIRDIFPWESVDDFITRIQRDYAGVKIDPEVERKLPTITYRDPFPGVPETGHYGITYVYRAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6C3</accession>
    <name>A0A132B6C3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol phospholipase-like protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062311.1">
        <property type="nucleotide sequence ID" value="XM_018216268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6C3"/>
    <dbReference type="STRING" id="149040.A0A132B6C3"/>
    <dbReference type="GeneID" id="28825994"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691271"/>
    <dbReference type="InParanoid" id="A0A132B6C3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="155"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="470" mass="51540" checksum="EDFC904B5B0BB1A2" modified="2016-05-11" version="1">MATPLVIRNLTKTPLELKVLERFDAAPSTDNGNGGISNITRTLSGLMGNFTSPSSSQIAAKSESFTNQDVSIPIGPFETKTTDIQPDPRGVLRLTFEAEGQRYRVDTPTPSQRSTTLTPLSPDPRLEFTAVHLPTSSHLALYSSAKLESWMGQLQNETPLSALSIPGTHNSPTHHTALPSVRCQAVSVKEQLNNGVRFLDIRVQPESPDNISKDGLILVHSAFPISLTGNKYFRDILNTVHSFLDANPSETVIISLKREGIGKATDQHLSKILHQHYVTDANRWFTDNRIPALGEARNKIVLIRRFAIDDSLKGENGGKGWAIDAESWPDNCADGICSSGEIRVQDFYEVAESENIEKKITFSRDQLARAAEAKCVIPDDMNAAVAESSKQPFFMNFLSASNFWRANCWPDRIAAKVNPSIVDHLCRKHHEPAGPGDGSCGIVVCDWVGSGGDWDLVRCIVGMNAKLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6E1</accession>
    <name>A0A132B6E1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_692007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061602.1">
        <property type="nucleotide sequence ID" value="XM_018216451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6E1"/>
    <dbReference type="GeneID" id="28826177"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692007"/>
    <dbReference type="InParanoid" id="A0A132B6E1"/>
    <dbReference type="OrthoDB" id="3439682at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="53" mass="6327" checksum="751B055B014BED2A" modified="2016-05-11" version="1" fragment="single">IGEILGWRLLLFTVSKEVVRPHQAQWDIDEKVLTYRNVDLHIDHMPRLLLSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6N9</accession>
    <name>A0A132B6N9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-binding oxidoreductase ToxD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_711819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062356.1">
        <property type="nucleotide sequence ID" value="XM_018217929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6N9"/>
    <dbReference type="FunCoup" id="A0A132B6N9">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="GeneID" id="28827655"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711819"/>
    <dbReference type="InParanoid" id="A0A132B6N9"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="39102" checksum="CCEE855316DA4DBB" modified="2016-05-11" version="1">MSLPKNRGLVKTAVGKAAILPIPIPRLRDEYILVKTVAVALNPTDWQTLDERFRPGTTHSLLGCDAAGVVVEVGSKVTKEFRKGDRVFGFSHGGNDLEPEDGCFAEYILMKGDISMHIPPNVSFEEAATLTCGFGTIGLGFYKHLGLPFPTLPVEKKSEGQAILIYGGSSASGTMAIQFAKLSGLEVITTASPRNFELLKSLGADHVFDYHDPNCGTVINALTNNTLTLVFDTIATTSSALICAAALSTTTSPSLPKKIYVNLMGIEFPRKDVENIFYLGYTMRGEPFEIEGEKWDAVPEDYELAKRFFAFCEVLLREDLVKGHPVRLLEGGLEGIQGGMEELREGRVSGVKLVARVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B882</accession>
    <name>A0A132B882_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_337845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062554.1">
        <property type="nucleotide sequence ID" value="XM_018206836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B882"/>
    <dbReference type="GeneID" id="28816562"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_337845"/>
    <dbReference type="InParanoid" id="A0A132B882"/>
    <dbReference type="OrthoDB" id="3589857at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="588" mass="65082" checksum="D97296237A29C8D4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8K4</accession>
    <name>A0A132B8K4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_600648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062352.1">
        <property type="nucleotide sequence ID" value="XM_018210165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8K4"/>
    <dbReference type="STRING" id="149040.A0A132B8K4"/>
    <dbReference type="GeneID" id="28819891"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600648"/>
    <dbReference type="InParanoid" id="A0A132B8K4"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19473">
        <property type="entry name" value="SET_SUV39H_DIM5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="149"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="35005" checksum="0CF58D157E4488B5" modified="2016-05-11" version="1">MAAAHLVCHENGLEKYAEEEKRCHYCQFRRFSTHYEFPISINNDVDNEGLPESFQFVNKVVPSADVPLIAEEFVSSCECVADHCVTQNCTCLSDIDASRLPGLKKNAYHATGQLRSAYLNGHYPIYECGDKCKCGQNCPNRVVQRGRTVCLQIFKTDDGRGWGVKTLSPIIRGYFVDCYFGELLTPDEAQARRDQASSVQQKDVYLFALDKFTDIRSPDPRLHAPYEIDGEFISGPTRFINHSCDPNLRIFAVVKNSADQPFHSLAFFALENIAPNTELTFDYLDGITGDGDDKEKTKCLCGAENCRGYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Y0</accession>
    <name>A0A132B8Y0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30S ribosomal protein S13p/S18e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_571499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063211.1">
        <property type="nucleotide sequence ID" value="XM_018208596.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8Y0"/>
    <dbReference type="STRING" id="149040.A0A132B8Y0"/>
    <dbReference type="GeneID" id="28818322"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571499"/>
    <dbReference type="InParanoid" id="A0A132B8Y0"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <source>
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        <source>
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            <dbReference type="EMBL" id="KUJ08856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="11332" checksum="E5C9F7AC87DB8398" modified="2016-05-11" version="1" fragment="single">AGELTSEELERIVTIIQNPTQYKIPAWFLNRQRDIVDGKDSQILANGVDSKLRDDLERLKKIRAHRGLRHYWGLRVRGQHSKTTGRRGRTVGVSKKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Z0</accession>
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    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="28104" checksum="6B28EA757FF0CA2E" modified="2016-05-11" version="1">MFGKRDIENPPVMNPNCKVQDGFGALASWMALEADSESFVFQKFDDLSARNLLYLQCEMLDLRRQLEAFDMKVARLDARMDLKDAARTWETLVRMSAEKDPNPDVQNYKILIERLRETVKEYLRSANLVRPSNRALKALRSWVDGGTTRRPDGTKIRPILGGLARDYLDKEDGLAVIKPLDDVVLLSKMLRNIWPVKREVSRDGINLIGRFQERSITLTVNIISVVVAAILLLGSITVSISFILLGLN</sequence>
</entry>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">LY89DRAFT_328852</name>
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        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A132B927"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="224"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="862"/>
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        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="162"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="884"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114244" checksum="862265CDE7EE2373" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9S7</accession>
    <name>A0A132B9S7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_676521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063515.1">
        <property type="nucleotide sequence ID" value="XM_018213596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9S7"/>
    <dbReference type="GeneID" id="28823322"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676521"/>
    <dbReference type="InParanoid" id="A0A132B9S7"/>
    <dbReference type="OrthoDB" id="3581633at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="270" mass="30273" checksum="C3F302AB48316263" modified="2016-05-11" version="1">MASLSLTLADIAGKAIDLQRQLALEPSPSNQLINQINDIHFLFDNVYRSYNKREQPTTATATDGATSSELVILSPTDTAHQAFAKGIHIKQSKHNPLPWMHLDVSLGKESKDKPTWRADARYRIQKNTNTSTVVKRRVRRHVVSQASSERSRVVGEVNDEDEEDDKVELDDTTSERNLEVTETYQEKVLNSPDDEVLPNFSTTFSSILAYRPKSATGSFIIREDRAFCGYGGFGIASQMIFRGCRLVITTAPELLNAKEYSKVLYDSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAE2</accession>
    <name>A0A132BAE2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_286026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063737.1">
        <property type="nucleotide sequence ID" value="XM_018206484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAE2"/>
    <dbReference type="GeneID" id="28816210"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_286026"/>
    <dbReference type="InParanoid" id="A0A132BAE2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="92" mass="10243" checksum="038C629A8E3771D1" modified="2016-05-11" version="1">MHSGRDVLRTRDQGTLGSRTSDSSSRTLGGISDSYKCWDCRHFVTLGLCTFLGVPRVWCDPHSLPIFLIISNSSRDTHTNELNTENTIISTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAQ2</accession>
    <name>A0A132BAQ2_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">Putative polyubiquitin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_628664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063850.1">
        <property type="nucleotide sequence ID" value="XM_018211187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAQ2"/>
    <dbReference type="FunCoup" id="A0A132BAQ2">
        <property type="interactions" value="1431"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BAQ2"/>
    <dbReference type="GeneID" id="28820913"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628664"/>
    <dbReference type="InParanoid" id="A0A132BAQ2"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.870:FF:000003">
        <property type="entry name" value="Polyubiquitin binding (Doa1 Ufd3) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="370"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="495"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="771" mass="83382" checksum="9CEF38BC3A07B5F9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBH8</accession>
    <name>A0A132BBH8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_701234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064096.1">
        <property type="nucleotide sequence ID" value="XM_018217181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBH8"/>
    <dbReference type="GeneID" id="28826907"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701234"/>
    <dbReference type="InParanoid" id="A0A132BBH8"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="58105" checksum="86113D66FF988217" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCA9</accession>
    <name>A0A132BCA9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_627433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064417.1">
        <property type="nucleotide sequence ID" value="XM_018211142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCA9"/>
    <dbReference type="GeneID" id="28820868"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_627433"/>
    <dbReference type="InParanoid" id="A0A132BCA9"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="261" mass="30334" checksum="732BF340310755A4" modified="2016-05-11" version="1" fragment="single">MVREGYRVQYEASNFTWTMKFAGRDKNMLYCFLRDMSETKIATQKIKYNARLQKGASRELKNNIWEDVSVKIGKVNGIGDKIEKVNFLKWIDVSLDLNRPLKMIDTPHGQLILDDAFKGRIYLKGLLLENSSTTKPFQFGYNFFNGTVDRDRKGLTHSSEEVSVLAQIWAAAIWSNEQDTLEKYVLMLRRQEAADVDQTEAYMSDATAKKVWEHLVMIDSEKKSFYHDRRNGDKDIEIIQSSLKKEPEQLPGSLWDALRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCC5</accession>
    <name>A0A132BCC5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_760840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064376.1">
        <property type="nucleotide sequence ID" value="XM_018221521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCC5"/>
    <dbReference type="GeneID" id="28831247"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760840"/>
    <dbReference type="InParanoid" id="A0A132BCC5"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ10021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="34972" checksum="0664F867C0B3838A" modified="2016-05-11" version="1">MFGPGRIIRGYPLCRAKRATTCTLPTAYHWTPTPNAPLVTPKNGWVSLKDFTHAPYNGSHLVYASNHDSSKYGSMNFGLFKSWSDMATAPQNGMTSATVAPTLFYFAPKNIWILSYQWGPTAFSYRTSSDPTNANGWSSAQPLFSGTISGSSTGVIDQTVIGDDTNMYLFFAGDNGKIYRASMPISNFPGSFGTSSTIVLSDTTNALFEAVQVYTVEGQNQYLMIVEAIGANGRYFRSFTATSLGGAWTKQTSGESAPFAGKANSGATWTNDISHGDLIRSNPDQTMTVDPCNLQLLFQGQTPGNGASYDQQPYRPGLLTLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCG4</accession>
    <name>A0A132BCG4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064460.1">
        <property type="nucleotide sequence ID" value="XM_018220597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCG4"/>
    <dbReference type="GeneID" id="28830323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740501"/>
    <dbReference type="InParanoid" id="A0A132BCG4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="22899" checksum="33CF986567D38170" modified="2016-05-11" version="1">MASQSPELPSPTVSTSKQESNHQHPSVVHQTAHSTGEAMAEENVEGEEPTLTDQPLNDGNEKPDDGACSDYTTADQQRTEDITSDEIETTSDIVRQARRTADSLDRDWETIIRVCIDLAEALAGTIDVDQMRKNKDVLINEMRGFTRRIEFLLQCVEILDASREELLENVERGSKFLQSLSETSETSQAARFSMVRELIEKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRK6</accession>
    <name>A0A194WRK6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_689296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064991.1">
        <property type="nucleotide sequence ID" value="XM_018215880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRK6"/>
    <dbReference type="GeneID" id="28825606"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689296"/>
    <dbReference type="InParanoid" id="A0A194WRK6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
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            <begin position="518"/>
            <end position="550"/>
        </location>
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            <begin position="820"/>
            <end position="852"/>
        </location>
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            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
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        </location>
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            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
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            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="923" mass="102865" checksum="417A7D4E2CE8A7C7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="78" mass="8433" checksum="1ACB12E17E225447" modified="2016-10-05" version="1" fragment="single">MNFLHLFLSLLWILFASLTTAASLPLTSRQTCTYGQYECAPGDVSFWVCAYGGYREVAGSCGEGEHCDDSTGSIVCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSL9</accession>
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            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25986" checksum="914E1246626F50A7" modified="2016-10-05" version="1">MDLSVKTEMGTHKGFTFEKFKLDGSALKEAAIASPYAVCVVCISTVFDHDILKLQNLPIDDYLRTQSRSKAMFAMGSASKTNSSATINLNKITKTKAQTQVDDQQVEPKVIEYSNAVNATTLITLPTEIHFLIFQHLDRVSSVCLGLTCNTLYPVYRETWKNGVPLDEFFGPDEFGKYTPLPILIQGFFPGLVFSFRRWAFETVELSMGKFAEELEKRYHLPLRRRPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT18</accession>
    <name>A0A194WT18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">LY89DRAFT_710274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WT18"/>
    <dbReference type="GeneID" id="28827543"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710274"/>
    <dbReference type="InParanoid" id="A0A194WT18"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="113" mass="11466" checksum="CADDA86F124BF3A9" modified="2016-10-05" version="1">MKHLAAYLLLTLGGNSSPSAKDITAVLESVGIEADEERLTTLLKELEGKDINELIAEGSSKLASVPSGGSGGGAAPAAGGAAAGGAAAEEKEEEKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT70</accession>
    <name>A0A194WT70_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_238592</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065510.1">
        <property type="nucleotide sequence ID" value="XM_018206077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT70"/>
    <dbReference type="GeneID" id="28815803"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_238592"/>
    <dbReference type="InParanoid" id="A0A194WT70"/>
    <dbReference type="OrthoDB" id="5351126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45273" checksum="E9170C4FA4CAB0DA" modified="2016-10-05" version="1">MKENHESGRFPLPSLPGIPTEILEIIAEYLPQQALHALMLTNSAFIEVAVVQMYEEPYFASTYRFAQFVHLVSRNEHLALLVRSLDISYITQPDDSVCEPGAGWREFSYRHKDMYPVTPPGFWPWKKQKPLVTHETLRTLGTQRTKSSHPPLSPLLGPSSRRNVPIGTMCHVLAACRRLKKVDLSELAIVSDAIFLSKELSRNDRRFEYGQFMTRFPTSDNPCLSSFSGPPESPSMHPWFVPASEVESQLLPPFSESDKKRGSRDDPYLPLTTNLKSTPSSCPSPMHVFETDIDNAERRKMAGKVWIYGDEIVSWLATLPELEELRLRGTMWINNTRTRRLVSDLVRPGDKLGGEKKTAAKGLQFLDLSHSGYVMCQREAWFGSREHVEEIVHKAYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTL0</accession>
    <name>A0A194WTL0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_688977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065369.1">
        <property type="nucleotide sequence ID" value="XM_018215820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTL0"/>
    <dbReference type="GeneID" id="28825546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688977"/>
    <dbReference type="InParanoid" id="A0A194WTL0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="293" mass="33495" checksum="C26903CE730E62CA" modified="2016-10-05" version="1">MTREPSDDTEGLLQKDELFDSDQLSRPTWQQKSKSWRAHLRVNQIYFAVIVLLIVSNITTLSFLSSLYATRQTYTPSVNQPPGGVPPTFKHLVRTPTPTFVNVSWYPPEDSFFREHNSTDADEKWKWYDASYGGYIMIPKEEAVTADIDPARHAYVDRPDLGVEGYPVLPEAIHEMHCVNMVRRNLYYNIEHTRAGCHPPNCEPPELESWRMQHVDHCLEIIRNRVACTADLGIVPFMWYGPNGKLAGDMARMHTCSNYDAIRKFVTEKGVLPGETKGILKPPEGAFITDLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU86</accession>
    <name>A0A194WU86_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_674107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065880.1">
        <property type="nucleotide sequence ID" value="XM_018213411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU86"/>
    <dbReference type="GeneID" id="28823137"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674107"/>
    <dbReference type="InParanoid" id="A0A194WU86"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="24497" checksum="0E12A8B7A96F8047" modified="2016-10-05" version="1">MDQHSLSEVTDLEREFMQRAAEEDALQLAALQEQVYGNLAGYGATQEEARQLAALQEQGNEAGYIAAQDEALQRAALQEQIQGNQAGYAAVQEEALQLAAQQQQVHSNLVGTGAGRYRQLGPHLYGGRGGYLDFGSGQIAEPTRQSVGDGEFRQGFLVENMARYVVDPREGFSRPRGLSSARWTDTSAQFPATGFTCDICGVVTQNEAYRLQHNRIMHGRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU99</accession>
    <name>A0A194WU99_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_594344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065895.1">
        <property type="nucleotide sequence ID" value="XM_018209795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU99"/>
    <dbReference type="GeneID" id="28819521"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594344"/>
    <dbReference type="InParanoid" id="A0A194WU99"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267524" description="Acyltransferase 3 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="38"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30505" checksum="3E43364122237037" modified="2016-10-05" version="1" fragment="single">MIISISLAILDVLLPSFIPRWASAAKETVSIRKNTPTAYMDGLRGIATVVVYLTHFAVNWFPILLARYGAQASDVFILQMPIIRVFFSGRAAVATFFVVSGYALSYSALTKIHKGQRAEAFDTLSSSAFRRCMRLYLPCAADTLICALLAYYGMFRHDPLNWHAIPPSLPTLNAQLWDWWEQLKILIYPFIYVEGAPFSPRYNGHLWTIPFEVRGSWVTYGTVLISANLTPIWRLAFFVTWAIYLWVMGKWDLFLFASGILIASLDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUE9</accession>
    <name>A0A194WUE9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase LipW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_710342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065592.1">
        <property type="nucleotide sequence ID" value="XM_018217821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUE9"/>
    <dbReference type="STRING" id="149040.A0A194WUE9"/>
    <dbReference type="GeneID" id="28827547"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710342"/>
    <dbReference type="InParanoid" id="A0A194WUE9"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36042" checksum="87F41C1C65D707EF" modified="2016-10-05" version="1">MSSLISKPCMDPELRLALGKVSFPPISRITPEIWKAMRVANATPPSFLDDQKVRGISHREVRISSQDGSNHEIILSILQRSVETTEPRPCLYWIHGGGLHWGDRLHTLEFPTDVILECDAVCISVEYRLAPEHPFCTSVEDCYTGLQWTSDHTQELGIDPKRLMVGGSSAGGALAASIALLCRDRTGPSLCAQVLFCPMLDDSLATVSSRQYVECSDFVPRGVFEDSWKASLANNGQNSNTVVLPPARVKDLSGLPPAYLDVGSAEVLRDETVAFASRLWENGVQADLHVWSGGFHGFDIFLPDAAVSQSSRRSKLMWARKVFQANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUI2</accession>
    <name>A0A194WUI2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_758332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065978.1">
        <property type="nucleotide sequence ID" value="XM_018221435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUI2"/>
    <dbReference type="GeneID" id="28831161"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758332"/>
    <dbReference type="InParanoid" id="A0A194WUI2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="25761" checksum="9B44CA751B309EDB" modified="2016-10-05" version="1">MELPYRLASQRSTVTNTPSVAGSRTTTPATSFDSTSAQPDLQRSGQKRTFEAANGATLDKGYSYGYHTPYFQPPLQLKPHRIPVLPSARFALPYERNAQTVDVSQAAKQLRTAKPSDAISFHLLYAHDKELTECQTCMLRWPSRVGAYHEFFPGRVDLLPTYSSDPAFRLGGEAGYDVIREQKCRELWHREEAKHVQDLGGYRAKPLHDGQKDYYDISEPLLKKPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUX4</accession>
    <name>A0A194WUX4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_722619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065819.1">
        <property type="nucleotide sequence ID" value="XM_018218743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUX4"/>
    <dbReference type="GeneID" id="28828469"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722619"/>
    <dbReference type="InParanoid" id="A0A194WUX4"/>
    <dbReference type="OrthoDB" id="5233393at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267473" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="302" mass="32014" checksum="7F5469F3EBFDF89D" modified="2016-10-05" version="1">MRFLFLTEALAFTSLATAHLIPRQAPASVYKGSGWIEFLVVRSNGDLLVNHLDKPEIWSLDSTTKAATKLATFANATSTTGITEYAPDQFAVVTGSFNITNISYTQGSWGVWKVDLSGATPKTTLVKEVPESNFWIGITPFNNDTVFIADAGKGAIYKMTLSTGNYSMILQDPTMIAPSGSLITEGIHGIVYNNGYVYYSNTFGNGFYKVKIDATTGKTIGAPIAVVPSMSNPEGFTFGPDGSAYVCSVGNKNIAKITPSGNMTTITDASGCSSVAFGRTAKDKSTLYISTSTGAVLSTTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYA2</accession>
    <name>A0A194WYA2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_756137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067270.1">
        <property type="nucleotide sequence ID" value="XM_018221364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYA2"/>
    <dbReference type="GeneID" id="28831090"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756137"/>
    <dbReference type="InParanoid" id="A0A194WYA2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="14091" checksum="C6197716B17D260D" modified="2016-10-05" version="1">MFVRDEPVEEWEDPIYEPPMNLDVIANLNVCHNLADAMHKMGLVNFEAECPPGALDMGSTDQGKVTYRCPGIHAGYFITDSVISNHTKKFTSVADSPEAETKTLQCAAGMGMVASALFLDKDFARRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYC2</accession>
    <name>A0A194WYC2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_756171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067290.1">
        <property type="nucleotide sequence ID" value="XM_018221365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYC2"/>
    <dbReference type="GeneID" id="28831091"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756171"/>
    <dbReference type="InParanoid" id="A0A194WYC2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267666" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="112" mass="11529" checksum="18C376C275786A29" modified="2016-10-05" version="1">MFKVFTLLAAMATGIIANEITDAAADYVGCTVNAYNTADCSGTIVSSTLHDCNVAQPCEAQAGASLELVCFNGCEGQLFVSVDDSCAGNLVVPAGECPEVQDVGQIQSQVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYM4</accession>
    <name>A0A194WYM4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_672843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213310.1"/>
    </dbReference>
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        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="GeneID" id="28823036"/>
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    <dbReference type="OrthoDB" id="6608471at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:L-serine transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cellular response to anoxia"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Mtc"/>
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        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SFXNs"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="340" mass="36391" checksum="2B1B7A6EE3565EC4" modified="2016-10-05" version="1">MSASIPGNRELPASQYDLSTYWGRVMHSANISDPRTLLVNAAGLEHAKSLVAGYKQGKIAEMNDELWKAKKVVDSTLHPDTGDPVFLPFRMSCFVISNLVVTAGMLTPGLGTTGTLLWQITNQSLNVAINNANANKSTPLSISKITQSYFLAVGASCSVALGLNALVPRLKRVSPATKTILTRLVPFAAVASAGALNVFLMRGEEIRQGIEVYPVLSEADKAKLAAEGKSESSVPSLGKSKKAATLAVSETALSRVLNSSPIMVIPPLILVRLQKQDWLKKNPRLTTPVNLGLILTTSLFALPLALAAFPQRQSVDASSLEKEFWDKGGENGKVVFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYP9</accession>
    <name>A0A194WYP9_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_756462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="40510" checksum="37C51B6DE54D54CB" modified="2016-10-05" version="1">MCSVDGSTTSALFRREMLPWMIQSPLMPHIAILMASASQTAEPTSLIVKPSEMIAIKSQVLGLINDFLKQDFTLVGGEALRAVIHLWWWGTTSSLWAHMAGIKQMIKLRGGFQAMNDPVLQQVFLVTDFELACCFERDLFLIDPAMANHMDIPIPPTYPEFLRSPLLAYHETFRHDRMVLGLSPEAAEILDDVRFLTLSITSPSDTTSTRKIQSTAAWLHERISTSPPLVPSPNAPFITVTTSMINLTALLYTLSISMLIPISELWTTTLLHEFYTNLYSISMSQWKEIPAIFLWVLLVACPGSQEDQRGKWLRRKMAVAGMQVGMEDFGVSIGCLRAFWRVQRWVQDEGSKQEASQDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZB2</accession>
    <name>A0A194WZB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_737835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067292.1">
        <property type="nucleotide sequence ID" value="XM_018220301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZB2"/>
    <dbReference type="GeneID" id="28830027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737835"/>
    <dbReference type="InParanoid" id="A0A194WZB2"/>
    <dbReference type="OrthoDB" id="3527999at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="16280" checksum="6B56B0A863DDDE40" modified="2016-10-05" version="1">MNLRLEDALRDFNTPKAVEILESSHNLSQNELNSALRIAISSSSPDTAIDHLLSHGAQITETVFYGASARKYVISFQAFLDHGWDINSLEFGQPALRLAVGDEQLVRWFLDHDADPNLQGTIGCSILATAALHPSTTLLEPLISRGAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1G0</accession>
    <name>A0A194X1G0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_698869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068042.1">
        <property type="nucleotide sequence ID" value="XM_018217013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1G0"/>
    <dbReference type="STRING" id="149040.A0A194X1G0"/>
    <dbReference type="GeneID" id="28826739"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698869"/>
    <dbReference type="InParanoid" id="A0A194X1G0"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267767" evidence="3">
        <location>
            <begin position="20"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="155"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="635" mass="68316" checksum="97BBD754058EB643" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X211</accession>
    <name>A0A194X211_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_590501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068237.1">
        <property type="nucleotide sequence ID" value="XM_018209598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X211"/>
    <dbReference type="FunCoup" id="A0A194X211">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X211"/>
    <dbReference type="GeneID" id="28819324"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590501"/>
    <dbReference type="InParanoid" id="A0A194X211"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="103"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="298" mass="34235" checksum="FBE73F6B5332D0B0" modified="2016-10-05" version="1">MHPNKRTLDTEEGSDDESRGYDSEGAEPQKGGRRGRGRGLKVASSEKESFNCGEEAQVLQEEHFCSELDSQKRLGSLGKPSESTRNPIKLTLGATDKAIQMSGVVYISRIPPFMKLHKLRSLLEKYGIINRIFLAPEESAARTRRVRNSRNKRKLYTEGWVEFVNKKNAKEACELLNTRVIGRKKSGYYHDDVLNLRYLKNFKWNNLTEQIAAENAERACRMRVEISKQIKEDKDFVRNVEKGKIMKTRQAKAMRKEGASSTKAIPAQRWTFDQIPLAKTRAQDKQPEQVRRALEMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X269</accession>
    <name>A0A194X269_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_736342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068651.1">
        <property type="nucleotide sequence ID" value="XM_018220114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X269"/>
    <dbReference type="GeneID" id="28829840"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736342"/>
    <dbReference type="InParanoid" id="A0A194X269"/>
    <dbReference type="OrthoDB" id="10637256at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43722" checksum="E766A90D0CD6CE89" modified="2016-10-05" version="1">MSSDLPYLQDMPESDAETAPSLPYENSSPEKANAKTERPDTEARSSTVQNQVREQLPQDETAVFPCFCLVIADPSEVITTETLIEAFRTHDGFLEACLATQENNPDLTPGYSYIAFNTEENATHAMRCLKTRDPDTKTYLMHAWTSKEISDTLEIPLLKHYPGVDLDITLPIKTSFHARVEELPKADPKNRGEFARAHLQMWDSLFKDKGLEFQKKAPGYILTRIFKEIDLNILDIRELQPGFEEIKDLHPSKTDSQEKRRNRRLYFAAISDLSENLVILDTLGTNLEEYPPLPKSENKRAAEKTARMPNERRKLDDNLDGDSKSDKAKVNYATNSLEEGEIEEESLSSDNLEDFVETDVGDFLRNETDSDFLEDEENPTLDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3E1</accession>
    <name>A0A194X3E1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermophilic desulfurizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_621069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068899.1">
        <property type="nucleotide sequence ID" value="XM_018210933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3E1"/>
    <dbReference type="GeneID" id="28820659"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_621069"/>
    <dbReference type="InParanoid" id="A0A194X3E1"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000025">
        <property type="entry name" value="Related to Dibenzothiophene desulfurization enzyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000032">
        <property type="entry name" value="Thermophilic desulfurizing enzyme family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="449" mass="49468" checksum="A8857802891868F9" modified="2016-10-05" version="1">MAPSVNDLLASNGDTIQEPNAKKVKPNPTSDPTVYDIHHQKFISDGLPSSSEAWIERARQVSAILAIDAASRDIENKSPRAEVALLKSSGLLKVLGPHAFGGGGQTWDVGYKVIREVAKGDGSLGMLLGYHLLWSTTANVVGTEEQKHRFQRLIIENNYFVGGAVNPRDNDLNITDHGDHLVFDGFKNFNTGGVVSDLTVLEGVFAGTEHHIFAFVPTEQQGIQFAHNWNNVGLRLTESGSVKINQIRVQWGDALGWDVSTKLPDPTVLAIPFATLLLPTIQLVFSNFYLGIAQGSLDFASKYTTTSTRAWPYGGDNKQSPTEEFYILERYGNFFAHLRAAETLADRAGLAITDIYTKHGEARTVTERERGDAAEWVASAKVVTTDTALRVTAGVFEVTGSRATGRKVGLDRFWRDVRTHTLHDPVAYKNRELGEYVLLDKVPEPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3F8</accession>
    <name>A0A194X3F8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069056.1">
        <property type="nucleotide sequence ID" value="XM_018215269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3F8"/>
    <dbReference type="GeneID" id="28824995"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686368"/>
    <dbReference type="InParanoid" id="A0A194X3F8"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="40536" checksum="65C0B57E4C261B5C" modified="2016-10-05" version="1">MPSAKASLKAMAKDAKSKKTPATPKKTTKQTSVPAPTNFKSTEYIQESDEEEDDEETKSETESDSDNDSLPANPADVTKNTNGKLPAPSGSSSSSDNESSSDESSGAESSGEDEHSDSSRRATVEPEPTKQRSAESSARRVAFDKPPTYKPPTGFETVSISDQSTASQILKKSNLREKQLWYFTAPASIPVSSIEQMSVADVDGGKTILSHDGTDYGFVQDPTGEKAYTTMFIPNSSEDAYLIASKSIDRVLHLQQTINIPGMNDADASLPLSSRATVPATKPVRQQPTGLKMRFRPIGFGAGKMGTIGSTSGDSSADGASDEEMEDAPAAFRRPVSEESDGEMEEVPPTSSKSKRKEKDKTAKSKSSPLKRKHGGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3W5</accession>
    <name>A0A194X3W5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-beta-lactamase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_698389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069094.1">
        <property type="nucleotide sequence ID" value="XM_018216976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3W5"/>
    <dbReference type="STRING" id="149040.A0A194X3W5"/>
    <dbReference type="GeneID" id="28826702"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698389"/>
    <dbReference type="InParanoid" id="A0A194X3W5"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="32016" checksum="02496251F457479B" modified="2016-10-05" version="1">MATQIIHLPEVDRLSARIIRILGGNPGKVRTNTYIVGTGQKRLLIDTGEGKPSWIANLKDVLTKENIIISKAIITHWHHDHQGGIKHLLECYPGTDIFKNQPDAGQQDIQDGQIFQVDGASLRAVFSPGHTQDHMSFVLEEEDAMFTGDNVLGAGTAVFEDLATYLNSLEIMRGKFQGRAYPGHGPVIEEGPAKILEYILHRKQREEQVVQILKSKSSNTAESQNSEPDEWASMDIVKIIYKDVPENLHVPAHGGVMQVLRKLETEEKVVQHPKSEKWRIKDRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X455</accession>
    <name>A0A194X455_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_589169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069311.1">
        <property type="nucleotide sequence ID" value="XM_018209516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X455"/>
    <dbReference type="FunCoup" id="A0A194X455">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X455"/>
    <dbReference type="GeneID" id="28819242"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589169"/>
    <dbReference type="InParanoid" id="A0A194X455"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16510" checksum="8DF5E7CC4F37D95C" modified="2016-10-05" version="1">MALKRINKELTDLGRDPPSSCSAGPIGEDLFHWQATIMGPGDSPYSGGVFFLAIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRSRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4D7</accession>
    <name>A0A194X4D7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069398.1">
        <property type="nucleotide sequence ID" value="XM_018215323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4D7"/>
    <dbReference type="GeneID" id="28825049"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686607"/>
    <dbReference type="InParanoid" id="A0A194X4D7"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="244" mass="28202" checksum="5FABEDFF859AA6D8" modified="2016-10-05" version="1">MDVAASASTPTASFHPFSRLPAELRVRVWSFTIWPRNVDFIMCGWQNQMNDNSFASSTTLKQRNAVPAILHVCRESRYEGMNFYTLLRHSITGLGIGYFNFDLDTLFISPRSSKDVKYHASQCSPAPWTNAMFFRLTSIAGNYVPTPLAELSCIGKQINIEQLHLIKTVVVPWDFVFLGFDLSREYMFCNMRGIRKITFMFEAQFARSSRLVSDMQSQLRAEADDTRARFPDWVEPQWEFEFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4N5</accession>
    <name>A0A194X4N5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_720253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069137.1">
        <property type="nucleotide sequence ID" value="XM_018218553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4N5"/>
    <dbReference type="STRING" id="149040.A0A194X4N5"/>
    <dbReference type="GeneID" id="28828279"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720253"/>
    <dbReference type="InParanoid" id="A0A194X4N5"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59212" checksum="F1B0322775F8A474" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X544</accession>
    <name>A0A194X544_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_783470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069656.1">
        <property type="nucleotide sequence ID" value="XM_018222687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X544"/>
    <dbReference type="FunCoup" id="A0A194X544">
        <property type="interactions" value="842"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X544"/>
    <dbReference type="GeneID" id="28832413"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783470"/>
    <dbReference type="InParanoid" id="A0A194X544"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="337"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="619"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ15301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="829" mass="90816" checksum="9212D0188C1F42DA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6F4</accession>
    <name>A0A194X6F4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DWNN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_94885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070110.1">
        <property type="nucleotide sequence ID" value="XM_018223526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6F4"/>
    <dbReference type="FunCoup" id="A0A194X6F4">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X6F4"/>
    <dbReference type="GeneID" id="28833252"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_94885"/>
    <dbReference type="InParanoid" id="A0A194X6F4"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="624" mass="68354" checksum="1F09035923111607" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7G5</accession>
    <name>A0A194X7G5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase get3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_648270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070461.1">
        <property type="nucleotide sequence ID" value="XM_018212004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7G5"/>
    <dbReference type="FunCoup" id="A0A194X7G5">
        <property type="interactions" value="1007"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7G5"/>
    <dbReference type="GeneID" id="28821730"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648270"/>
    <dbReference type="InParanoid" id="A0A194X7G5"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="340" mass="37469" checksum="1B0E694E29EA449A" modified="2016-10-05" version="1">MSTAVINTDDDQLEPTLQSILDQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLVNGFTNLSAMEIDPNGSIQELMGQAEEGEGPAAGMGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPTVLEKALVKISQLSTQFGPMLNGLLGANGALPNGANLNEMMEKLEGLRETISEVNTQFKDENLTTFVCVCIPEFLSLYETERMIQELASYGIDTHCIVVNQLLFPKAGSECEQCNARRKMQKKYLEQIEELYDEFNVVKMPLLVEEVRGKEKLEKFSEMLIHPYVPPAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7N5</accession>
    <name>A0A194X7N5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_646481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070474.1">
        <property type="nucleotide sequence ID" value="XM_018211926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7N5"/>
    <dbReference type="STRING" id="149040.A0A194X7N5"/>
    <dbReference type="GeneID" id="28821652"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_646481"/>
    <dbReference type="InParanoid" id="A0A194X7N5"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="70"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="317" mass="35090" checksum="E631398555D98159" modified="2016-10-05" version="1">MLNKAGRAKLAKETVNTLIPHILKTNSRAHEGANSSELVSYSLLDTSRLRDSPASTKHTKSPTSTSQQTVKDVSNDMEETQLAESPTPVSATSSTHPRTRVVQSDTYDAVKDLLAEDTSSKDPPRVGTLNMASSYSPGGGFMNGALAQEEALCVRSTLYYSLKPSYYRIPELSAIYSPDVLVFRGSDMKDLPKSEWFFTDVISVAALKQPELKWNLDRTRLIYEYPQDKDLMLEKIRLIFQVMAEKGIKRIVAGALGCGAYRNPPEEVAKMFRNVLLGDKKRKGVEGIDEVIFAIFDDGPNLKAFREVFPDGENDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X861</accession>
    <name>A0A194X861_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_707647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070710.1">
        <property type="nucleotide sequence ID" value="XM_018217623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X861"/>
    <dbReference type="STRING" id="149040.A0A194X861"/>
    <dbReference type="GeneID" id="28827349"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707647"/>
    <dbReference type="InParanoid" id="A0A194X861"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.340.10:FF:000004">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000013">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="7"/>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="672" mass="71122" checksum="F4387612CE78B03E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="496"/>
            <end position="545"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ16072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="62896" checksum="1209B874FB4A4870" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8X0</accession>
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        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="18052" checksum="1DDC6B11BBFC5D46" modified="2016-10-05" version="1">MEELKTARQNFEVVDRMAKNGVLLEGAFALGYEQLRRNVSNLEIIVEKLRFPDRVDDSTVDKAYEQYWQDNPDMPRDTHRQAAPRPATQQSQSIADPAAPPTQSGDEVEDSLAQLKIDPASEDAETEEEEIVEEGDSSSRAETDDKSTESSAPAKADVPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
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    <dbReference type="OrthoDB" id="7457040at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ16806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="532" mass="59050" checksum="4D346A5A277BD864" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9N8</accession>
    <name>A0A194X9N8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">LY89DRAFT_66083</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071194.1">
        <property type="nucleotide sequence ID" value="XM_018212568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9N8"/>
    <dbReference type="FunCoup" id="A0A194X9N8">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9N8"/>
    <dbReference type="GeneID" id="28822294"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_66083"/>
    <dbReference type="InParanoid" id="A0A194X9N8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ16839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="41284" checksum="B0B4678E00C498A2" modified="2016-10-05" version="1">MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSAKDQLTGQNVAVKKIMKPFSTPVLSKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIHTIASENTLRFVQSLPKRERQPLKDKFRNADPLAIDLLEEMLVFDPRKRVKAAEALAHEYLSPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDTANAEAQAMEGFTNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA10</accession>
    <name>A0A194XA10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_585974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070962.1">
        <property type="nucleotide sequence ID" value="XM_018209351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA10"/>
    <dbReference type="FunCoup" id="A0A194XA10">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XA10"/>
    <dbReference type="GeneID" id="28819077"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585974"/>
    <dbReference type="InParanoid" id="A0A194XA10"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990845">
        <property type="term" value="P:adaptive thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000003">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="301"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="584" mass="65618" checksum="3C1DF233C505B9EF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBR4</accession>
    <name>A0A194XBR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_58197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071959.1">
        <property type="nucleotide sequence ID" value="XM_018209137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBR4"/>
    <dbReference type="GeneID" id="28818863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_58197"/>
    <dbReference type="InParanoid" id="A0A194XBR4"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="47"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="39048" checksum="F33768CA8FF57B26" modified="2016-10-05" version="1">MVNAFTTIYETTYPARGPVLKLRGSSESFQHGSLTVTPVIMSDNSSFGAEISGIEWNNAIDPEVVKQLIGLQDKYGVLIFRKTGLDNARHIAFSQQLGEKLEVNPFFYGIEKDRVKEPFLWDVGNIELDGSLVRPNSRRWHHSLGNALWHTDSSYHQHRSKYSLLLAHKTPNSGGSWTHFADTRRAYAELPQAKKNFLENLVIEHDLWHSRKLGSPEVYGNPLPHELAAKPPAYHRLVQVAPDGRKTLFLAAHAKRVVGWSLEESQKLIWELIDHCTQLKYVFSMEWLSDGDMVWWDNRQSMHRANPYTESMGARDVRRTTIIDDGPLALGVSAEEMITMKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBU5</accession>
    <name>A0A194XBU5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_668939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071990.1">
        <property type="nucleotide sequence ID" value="XM_018213059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBU5"/>
    <dbReference type="STRING" id="149040.A0A194XBU5"/>
    <dbReference type="GeneID" id="28822785"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668939"/>
    <dbReference type="InParanoid" id="A0A194XBU5"/>
    <dbReference type="OrthoDB" id="3437411at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="69442" checksum="F7FA5C45A1F2DB94" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBW9</accession>
    <name>A0A194XBW9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_733502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072023.1">
        <property type="nucleotide sequence ID" value="XM_018219807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBW9"/>
    <dbReference type="GeneID" id="28829533"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733502"/>
    <dbReference type="InParanoid" id="A0A194XBW9"/>
    <dbReference type="OrthoDB" id="3591358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="731" mass="80257" checksum="C57881BF2091E33B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCX0</accession>
    <name>A0A194XCX0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_584513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071957.1">
        <property type="nucleotide sequence ID" value="XM_018209267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCX0"/>
    <dbReference type="GeneID" id="28818993"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584513"/>
    <dbReference type="InParanoid" id="A0A194XCX0"/>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="2">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16008" checksum="5A8106D51416A300" modified="2016-10-05" version="1" fragment="single">MSHSDSFFSSGGRPAPNLGIYARVVHNEGDAKAGFKYFSYLINGCLGLQIVVAAALTALGAAGGSRGAVTVFGAINTVIAGILTFLKGSGLPNRFKYYQTEWKRVREFIEQRERDFSRPTCDLDVYGVVAIVESMYEEVKLDLEASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE13</accession>
    <name>A0A194XE13_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_47348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072746.1">
        <property type="nucleotide sequence ID" value="XM_018207785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE13"/>
    <dbReference type="STRING" id="149040.A0A194XE13"/>
    <dbReference type="GeneID" id="28817511"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_47348"/>
    <dbReference type="InParanoid" id="A0A194XE13"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="169"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="265" mass="28337" checksum="F9BE7EA9C9E56F83" modified="2016-10-05" version="1">MVACPICGKGVKSKDINDHIDSGCESYLESPPLTQNGSTQNTTASQKPSVSSFFQTPAAKKAVSYPTPKPEPSPTLSIQQKPASNGKPNTSNPPPRKRSFEDITTAVKEEVEPVIKNEDVQPAKKTKTNAFQKAAPLAERMRPTSLDDVCGQDLVGPQGVLRSLIEQDRVPSMILWGGAGTGKTTIARCIASMVGSRFVEINSTSSGVAECKKIFAEARGELGLTGRKTIIFCDEIHRFSKSQQDVFLGPVESGQITLIGATTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XED2</accession>
    <name>A0A194XED2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_732105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072900.1">
        <property type="nucleotide sequence ID" value="XM_018219647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XED2"/>
    <dbReference type="GeneID" id="28829373"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732105"/>
    <dbReference type="InParanoid" id="A0A194XED2"/>
    <dbReference type="OrthoDB" id="3558721at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="408" mass="46566" checksum="1C654C3D32BB4A95" modified="2016-10-05" version="1">MATPETPPVTSCAVPGIDQSVSQEIPGTIENLTMKSEIGIPAGDVECKKRNFIRRIPYNNGYGNFVFHRWLEDPVDCVRPNFNLWRDGSYGNSVKELDGFERSGSFAFFKLPDLIRKMVFLLLLRPLFEYDKDSEKSFVQFIFGESSAWVGNELMLLTKKATPKPYWAGWRMGIDWHFLESIRQASNVNTTFRKELADTLWSRTGIATYGNNSWLAIPEILQQRPSICAGIKYLYIGLDLSRERNTDSFEDWCESLSQRLILERLTVKVLMEKEDIPRVLSEWFPNLAAAETLNVTQSFTVSVSIRLGGEKPGQILDESGSGINEQYRKELVELMMPKSLRPKVFLSATETYLESRHHITSNNPPTMSSAPCIFCVEIQEPFPGIDSFDKIFLLRATYLERAKEHKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFN3</accession>
    <name>A0A194XFN3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_774412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072937.1">
        <property type="nucleotide sequence ID" value="XM_018221964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFN3"/>
    <dbReference type="GeneID" id="28831690"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_774412"/>
    <dbReference type="InParanoid" id="A0A194XFN3"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="81"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="31168" checksum="705D9E54A21F8EDC" modified="2016-10-05" version="1">MSAMLPWQIPAPPAPIIPQYDPRKLALLVETRPLPHLPALFTHMTTIIPPEWTFKFMGSPAALSFMRSSPVISRFEDSGKLQLLPIPGNYSLKDRETISQMFTDIHLYRDLLAPAEHLLVWQPDSIFCANAAKTLNDYLEWDWIGAPWSKTAQYGGNGGLSLRKVSKILEVLRSKQRKVGDGALEDLWLTNNLHELPGSHMPNAAVSKTFSVESVWDDAPLGYHVGWLGVHHEQIWDDKGQVDHIMKYCPEVKMILGMKLDNDKPEAIRQSENPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGA7</accession>
    <name>A0A194XGA7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 74 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_706044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073526.1">
        <property type="nucleotide sequence ID" value="XM_018217494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGA7"/>
    <dbReference type="GeneID" id="28827220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706044"/>
    <dbReference type="InParanoid" id="A0A194XGA7"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Xyloglucanase Xgh74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
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    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268209" evidence="8">
        <location>
            <begin position="18"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="720" mass="76320" checksum="5525EBD3B5609004" modified="2016-10-05" version="1"> </sequence>
</entry>
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    <accession>A0A194XGQ5</accession>
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        <name type="scientific">Mollisia scopiformis</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
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    <dbReference type="GeneID" id="28817779"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_508562"/>
    <dbReference type="InParanoid" id="A0A194XGQ5"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="20412" checksum="1ED35F24E9C80D5A" modified="2016-10-05" version="1">MVPAGSNWKNRPCIATERMDHLGVGCSNLWAEYVPKDLSIEDPFVTTFRTKTIKRATRPGIVLLKYYSSRNKRNFNLAEASTRYEDASRPLIRWWLAYVPASPEARVSPMVYTKKILQRCCVRLALDLESSRRSLLLVLNSCLVGYNRDSLSNFRQPRTQCLEYIGDVCQVCRSVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <name evidence="1" type="ORF">LY89DRAFT_535852</name>
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    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
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    <dbReference type="KEGG" id="psco:LY89DRAFT_535852"/>
    <dbReference type="InParanoid" id="A0A194XGT3"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28000" checksum="EE806E3F0C5FD995" modified="2016-10-05" version="1" fragment="single">ALAFSSLVNGHMMLLNPAPLRAKNNPHSKQSAIDYSYTSPLSGPSQFPCKGYLVDMSDPSGAGASVQTYTAGAASSFSVTGGATHGGGSCQITLAYPADNFRKFTVIHSYEGSCPLSDGQEFPFTVPADAPTGRAAFVWTWYNKIGNREIYQDAAAVTIIAGTGSTPDIPFSERPDIFVANMGSCTTIEGTEVIFPDPGPDVTRMLSNTMASTMSSTIKGVCLPVNGIGNSGGSNGNAGPGVASSSLSMPPPTQATATLASSASFFTALPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH84</accession>
    <name>A0A194XH84_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_492309</name>
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    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073856.1">
        <property type="nucleotide sequence ID" value="XM_018207906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH84"/>
    <dbReference type="GeneID" id="28817632"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_492309"/>
    <dbReference type="InParanoid" id="A0A194XH84"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="85" mass="9463" checksum="D332CCC802BCDF2C" modified="2016-10-05" version="1">MASSVKSNCSFLLSFHTTTHSTHIPTNKIPHSLHSPSKQTTNRPPIICSIVLSTLPKNTIVPRKSKTAEKDRCPQIKKQNQQKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHV8</accession>
    <name>A0A194XHV8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_488965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073712.1">
        <property type="nucleotide sequence ID" value="XM_018207878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHV8"/>
    <dbReference type="GeneID" id="28817604"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_488965"/>
    <dbReference type="InParanoid" id="A0A194XHV8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17657" checksum="A0A26175DDEB673B" modified="2016-10-05" version="1">MMAPALEERKGQQGKKKHPLREHRHRLQPSFIPPYNINLQPCLNLSIRFLVLFPCAYLHGIYCRITGVWDDSGPPTWVPFARFTPSGILHASSWLTCIIPFLPRTRLLVTEGFKPTWVSAMMDNGRWRWQCTTHEAGRLTYHALEDRDREGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHW8</accession>
    <name>A0A194XHW8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_731066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
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        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
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            <begin position="735"/>
            <end position="746"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19815.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="791" mass="88557" checksum="813853E2FF13F144" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK67</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="253" mass="28266" checksum="0F0E2691B56504BE" modified="2016-10-05" version="1">MSSASDSAAIHPQNINGLSNGSLLQKQNFVQANSESFSEWYSFVTAQSEPPTIDCNSFDEWSYDSTTFNQHCPSPIASSLGSSIVWTSHAAAEPLQYGSLSPLTETPLSYWNCERPLMRLGEICVSSATQPFASPFYTHTEATESSYPIQHQPDYNHTIRDKNTTSPLFVNNAASSRSTRASRSRSRLRPKTLHCPNCELSFARASDLQRHIDGIHLRIRHHCRVSGCGDNDKKGWCRLEKLKGHMQHVHGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKH7</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="140" mass="15606" checksum="C1E04D54B3CA8D1C" modified="2016-10-05" version="1">MGAKVPRNFRLLEELEKGEKGLGAEACSYGLAEGDDLLMSNWNGTILGPPHSVHENRIYSLKMHCGDQYPDKPPTIQFISEVNLPCVSPRNGVVDPTKLPCLANWTRDMTMETVLIELRRFMAHPANKKLPQPPEGSTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLS1</accession>
    <name>A0A194XLS1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_715457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075550.1">
        <property type="nucleotide sequence ID" value="XM_018218208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLS1"/>
    <dbReference type="FunCoup" id="A0A194XLS1">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLS1"/>
    <dbReference type="GeneID" id="28827934"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715457"/>
    <dbReference type="InParanoid" id="A0A194XLS1"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="388" mass="45307" checksum="4621D7776497F475" modified="2016-10-05" version="1">MANYRYYTRRFRRIAATPTFQLVAVCLFLIFGINWVIKHNHDDDGDHLPSARPTTTVEDESIDWSKLYYVQYATSPEYLCNALMVWAQIEDIGSRAQRMMLYPSTWNPDEIDEYSPSLDYTPIARLLQEAQSKYYVKLQPVDIMHRNGTLQPTWADSYTKLLAFNLTQLDRVLALDSDSMVLKNLDSLFLLPKSPVAMPYVYWGAPTGWAFSSQMLLVTPSATTFSEIESAIQNAKEDEYDMDIINKLFNHHILKIPQRPYNLLSGEFRRSSHAAYLSSRTKKWDPDEIFADAHFLHFSDWPIPKPWMVAPKELLNKHMPKCRMSEWFGATDCRDRALWLKLYWDFAVRRKSVCGIGFELQSQELPEDSIYRHGRWYHPDEVGGSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMN8</accession>
    <name>A0A194XMN8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_681904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075751.1">
        <property type="nucleotide sequence ID" value="XM_018214399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMN8"/>
    <dbReference type="STRING" id="149040.A0A194XMN8"/>
    <dbReference type="GeneID" id="28824125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681904"/>
    <dbReference type="InParanoid" id="A0A194XMN8"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="287" mass="29840" checksum="6F5F7E596DC7272B" modified="2016-10-05" version="1">MADYSQMKVPDLKKILQERGLVVSGNKADLIARLQEDDKKAGGAAAGAGEDEIDWDEDDNKATAPATATTEPAAAAVAAGGQGPVDTPIAVPNQKVDVDPSTTTDLKVSGGEDAPTATDGAVASAGTTTTEPAPAPVEEAPKQDFSIGLEKSDAQKEAEKRAARAKRFNIPENEEAKKLAERAKKFGLDGKDTVISGLDSALPERRQKRAREEKNGGNGGGGRAAKRQTPDRRSDPKPKGSAPSSKKESFGKITDDPVEKAKAEARAKRFGKPAVEATPAATATTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMQ0</accession>
    <name>A0A194XMQ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_577470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075407.1">
        <property type="nucleotide sequence ID" value="XM_018208894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMQ0"/>
    <dbReference type="STRING" id="149040.A0A194XMQ0"/>
    <dbReference type="GeneID" id="28818620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577470"/>
    <dbReference type="InParanoid" id="A0A194XMQ0"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ21052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="28107" checksum="C76149FF530A60BF" modified="2016-10-05" version="1">MASSELTTIPGSLEHVRIQALPSSAFYIAEFITIDEERMLLEKIETAPKPRWKQLSKRRLQTWPSDLTNNTLLDSPLPKWLTEPVITRLLTLPITASKPDHIFSESPHGAPNHVLINEYLPGQGIMPHKDGGAYYPVVCTVSLGSPLCLDIYGTKDDGSREAEPKWKILQEPRSLLITTDQIYADFMHGIANVTDDVDLGSSTVANWDLLRTSSNIQNHRSERRTRLSLTYRDVLKVSKLGGTLGSMFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMR6</accession>
    <name>A0A194XMR6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_665819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075739.1">
        <property type="nucleotide sequence ID" value="XM_018212869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMR6"/>
    <dbReference type="GeneID" id="28822595"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665819"/>
    <dbReference type="InParanoid" id="A0A194XMR6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="169" mass="19279" checksum="C5BAF39ECAE445E5" modified="2016-10-05" version="1">MSPYASQMATILSKAEDMGRNGVDIVEIHTKYLARYHDITDQPARDWLSELSTWTSLFPGESFQGVCPHEQLDPETARIALQSLQVILDDRDRTIEDYIKQVDIWQEEENELKKLGEASKKVIDTSARSDTMIPLLDQLLGEVQSMKLGDDFMDKDRLNGFEDTLGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMT0</accession>
    <name>A0A194XMT0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_715632</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
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            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28827947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715632"/>
    <dbReference type="InParanoid" id="A0A194XMT0"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0132">Cell division</keyword>
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    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="341"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="590"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
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            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
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            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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            <end position="638"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="694"/>
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    </feature>
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        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
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        <location>
            <begin position="735"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21463.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="836" mass="92110" checksum="02BF3553D847D03F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNE4</accession>
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    </protein>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
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        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="3164" mass="358081" checksum="60397ACCF8838877" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNK3</accession>
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        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNK3"/>
    <dbReference type="GeneID" id="28818596"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577056"/>
    <dbReference type="InParanoid" id="A0A194XNK3"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="931" mass="104017" checksum="14B6C55E26B931AA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNS1</accession>
    <name>A0A194XNS1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">LY89DRAFT_681167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076114.1">
        <property type="nucleotide sequence ID" value="XM_018214219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNS1"/>
    <dbReference type="FunCoup" id="A0A194XNS1">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNS1"/>
    <dbReference type="GeneID" id="28823945"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681167"/>
    <dbReference type="InParanoid" id="A0A194XNS1"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000132">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="47037" checksum="0D242542D0717478" modified="2016-10-05" version="1">MAPALCAICENARALVKRPKNGQKLCKACFITIFEEEIHHTITTTKLFSPGDRIAIGASGGKDSTVLASVLKTLNERYNYGLDLVLLSIDEGIKGYRDDSLETVKRNAIQYDMELKIVGYDELYGWTMDQVVETIGKKGNCTYCGVFRRQALDRGAKMLGIKHVVTGHNADDVAETILMNLLRGDLPRLARSTSIVTGDESSEVRRSKPLKYAYEKEIVLYALHKKLDYFSTECIYSPEAFRGSARTLIKSLERIRPSAILDIVRSGEDMAKLVPAEVTGISHCKSQKVSLSSADGEEEGAGGCGSNGRSSGGEMAEMEKKLQEDEEASSREFDVASITPRKANGQRHDRIGGRNGLKKDPGRKLTRQTLGTCKNCGYMSSQDICKACMLLEGLNKNRPKMEIEVDVEDEESSTLRRRMEGLALAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNU5</accession>
    <name>A0A194XNU5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Het-C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_694308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076186.1">
        <property type="nucleotide sequence ID" value="XM_018216695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNU5"/>
    <dbReference type="GeneID" id="28826421"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694308"/>
    <dbReference type="InParanoid" id="A0A194XNU5"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268498" evidence="2">
        <location>
            <begin position="29"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="797" mass="86112" checksum="3DF37B6FB70D042D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNZ8</accession>
    <name>A0A194XNZ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_384723</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076159.1">
        <property type="nucleotide sequence ID" value="XM_018207147.1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPF0</accession>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="491" mass="54088" checksum="B03DCA375967FDC5" modified="2016-10-05" version="1">MSKRRADDQENGGVSLKSGERPEKSGLEDEVGEFEDEFEDEYESEDEILEAGVDGRPDAEREAEEKAAMDVDQQTFIVGRNKLEPGQTLSPDLSTYEMLHALSTPWPCLSFDIVKDSLGDNRKTYPATMYAVAGTQAESRREKENQLMVMKFSGLSRMDREHDEEDSSDDEDEDADPILESASIPFTSATNRIRAHQIPASDSSRPPTTLTASMTEAGQVLIHDVTPHLASFDTPGTIITPQQNKPLSTLRMHKSEGYAVDWSPLVSTGKLLTGDNDGKIFVTTRTAGEGWVTDSRPFTGHEGSVEELQWSPSERNVFASASSDGTIKVWDVRSKSRTAALSVQVSNTDVNVMSWSHQTTHLLASGADDGVWAVWDLRQWKPNTASSTPAKPTPVASFNFHKEQITSVEWHPTDDSIVAVAAGDDTLTLWDLAVELDDEESKDTGGVTEVPPQLLFVHYMEKVKELHFHPQIPGCLVGTGEAFNVFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQH1</accession>
    <name>A0A194XQH1_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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    </evidence>
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</entry>
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        </submittedName>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
    <sequence length="680" mass="74466" checksum="CE6264A90249B1CB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076828.1">
        <property type="nucleotide sequence ID" value="XM_018214111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQJ9"/>
    <dbReference type="GeneID" id="28823837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680620"/>
    <dbReference type="InParanoid" id="A0A194XQJ9"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="37045" checksum="81F7D7B19D0ECA0A" modified="2016-10-05" version="1">MIRRKSSEPESSSSAATGHKKKEGEGLDTWMGGLHYQRGVLQREPLRRWDELEVWQQDDNQFIETGYRSASGSLSACFYSWKYLHNESVNIYSHLIGAAIFFILPAYLFRKEIPLRYAVATAADIIVFSAYFFGGAICFCLSATYHTLLSHSKSVERFGAQLDFQGVILLMWSATIPLLFYGFHCDVDLRNAYWTLLSVLAVICSISTFQPHFRGPYLRFVRAGTFGSLAIFTMVPVFHGTFKYGWAVQNQQMGVSWVITTLVVDILGATAYALKIPERWWRKTFDIWGASHQIFHVMVIVAALTYTKALLQAFDYVHADGKSCSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR33</accession>
    <name>A0A194XR33_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_574822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076869.1">
        <property type="nucleotide sequence ID" value="XM_018208763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR33"/>
    <dbReference type="FunCoup" id="A0A194XR33">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XR33"/>
    <dbReference type="GeneID" id="28818489"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574822"/>
    <dbReference type="InParanoid" id="A0A194XR33"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="191"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="292"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="42863" checksum="5BC32CFB53B69B11" modified="2016-10-05" version="1">MDLLFPSQDTLHDVFHPAIPFGRRPVALAEKQAVSFPPKRTPLQARSELYTAWSVVDDAKNKTNALSAEAAKEFEKASAKAQAKTGHIELYSAQYYAACTFGGLLACGLTHTAVTPLDLVKCRRQVDSKMYTGNFQAWGKIARAEGFRGIYTGWGPTFFGYSAQGAFKYGGYEYFKKFYSDLAGPDNAYKYKTALYLAASASAEFIADVALCPFEAVKVRMQTTIPPFASGTFNGISQITSKEGFGGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYERLPGQKSDYGKGAQTAVSFTGGYLAGILCAIVSHPADVMVSKLNANRQPGEAFGAAMGRIYKDIGFSGLWNGLPVRIVMIGTLTGLQWMIYDYFKIFMGFPTTGGAAPPPQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSZ3</accession>
    <name>A0A194XSZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_663622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077514.1">
        <property type="nucleotide sequence ID" value="XM_018212717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSZ3"/>
    <dbReference type="GeneID" id="28822443"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663622"/>
    <dbReference type="InParanoid" id="A0A194XSZ3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="451" mass="49084" checksum="712B3ABFD7FB9573" modified="2016-10-05" version="1">MARGKKGKTNKAVESSHSAGNTSSSQVGAHSTQHNVLPLRISNNTATAAIAKSTKRRVERAMSDSQHASGSGDGIEPQMASMENDRPAKKLKLTAGVLRDWAFIGVLIDEPTLEVFARFASDDRVWAKAVPKEGAPDIGNINHVNMSKVELSTKVIQHYGQDTTNVPKNDIVRNFLSANLVYDPPYLEVGTRSGLNSSPVYAKVIRNGKYRSLLFFLEKNTFDIEKSINTDQIKFGLDYEKATLKNTTDYINDLFKMKYKSVVTGPPNPIIPRPAADGPRNEPRPAPGLAPPALNIGPSNEPRPAPQQAPPAVKVGPMDMGLTNLQVSMANLRQAGELYEKNITAQDIVIGGLKKTVADQDIAIADLERRVALDEKLRAEQEKRLAEGNKTIKKHEATISNLEVSLKEAGETVTNIRNAINKHQDNGNDEEEPSTNKGKAVAGSSKKKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT31</accession>
    <name>A0A194XT31_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_680120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077713.1">
        <property type="nucleotide sequence ID" value="XM_018214016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT31"/>
    <dbReference type="STRING" id="149040.A0A194XT31"/>
    <dbReference type="GeneID" id="28823742"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680120"/>
    <dbReference type="InParanoid" id="A0A194XT31"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="19519" checksum="8380FB0FCF66675B" modified="2016-10-05" version="1">MASPANSVPDTQLGLTNDEIALLRHHQQAAASTAGGSSSRAASRASSQGLLLLDGSSLAALGRHFDRLMQQIQARLDYLAEQSQMVAQQQYDRAGNAIALADSEIARFHDILRQIDELEVDFDRIRHIRDIVRSYRQRVEEMEQQMEHSGSSSRHRHRHHGESSGSSGRRHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTP5</accession>
    <name>A0A194XTP5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_573392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078045.1">
        <property type="nucleotide sequence ID" value="XM_018208685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTP5"/>
    <dbReference type="GeneID" id="28818411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_573392"/>
    <dbReference type="InParanoid" id="A0A194XTP5"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="350" mass="37802" checksum="138567DEDFE901FB" modified="2016-10-05" version="1">MPPTNKAAWLLTYENPSLVVKEAPYTFPSTNQIVVRAHAVSINPVDAAIPFRGAVVFPWLKLPFILGSDISGEIVELGPGVENLKVGDRVVGQCLAWQHNNPVEGAYQEYVVMQQNMVCKIPDEIPYEEAAVLPLCLATAACGLFEKRFLGLEFPSFEPREQGKTVMIWGGSTSVGCNAVQLAVAAGYEVFSTASPKNFEMVKKLGAKMVFDHNSATAVEEIVAALKGKTIAGAYAIGAPTSDRNGFSAGEACLEIVKRSEGRKFAAMAMHGPAELAPEGVEAKFVTGEQFKTNEVGKMIYGEYLPRALKERKFLCMPEAVVVGNGLEKIQEAFEVQKKGVSAKKIVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUF8</accession>
    <name>A0A194XUF8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_777105</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077697.1">
        <property type="nucleotide sequence ID" value="XM_018222112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUF8"/>
    <dbReference type="FunCoup" id="A0A194XUF8">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUF8"/>
    <dbReference type="GeneID" id="28831838"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777105"/>
    <dbReference type="InParanoid" id="A0A194XUF8"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
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        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="342"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ23342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="892" mass="97601" checksum="A5F912C45FD9F94A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUK3</accession>
    <name>A0A194XUK3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_755282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28831073"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_755282"/>
    <dbReference type="InParanoid" id="A0A194XUK3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="244" mass="27380" checksum="0698236EF34DFB3B" modified="2016-10-05" version="1">MADHAEDTRAFKQFGSLPMELQLRIWKFAIPAPRIIKVYAGLIEGPETTNTEATRDNTHVDTSGILSQYASPLQLSALLETCKISRDELLKTYKSSIKMDLEGKQTLYFDTDTDIILLVVCDFEVFGNHGLGSDGRFAGIKTLALPCFQAESELLDLFPSRFPSVQTLILIGFTDYEPDFTFKSKASNNEPLRWEGIEAAFGAHGETLDSCNIKANHPEWIVPEIKMLYNTGEGAIYIDEDAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUT0</accession>
    <name>A0A194XUT0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_712796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_712796"/>
    <dbReference type="InParanoid" id="A0A194XUT0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268627" evidence="1">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="217" mass="23903" checksum="621A2D245E618F56" modified="2016-10-05" version="1">MARNKALALISCVGLFAICTLCQNTLTSRVKRLHQLWGSGGNSVRLVSKLFVPVSTKRVWNAVHLGMTYARDLTVRHEVMGLVRKDGDSHGMKLQMKLPNLFIGSLLALLVELSRAQDLSRGVIRKEGWQRLSRAEMPASGNSTISWVETARTHARTANFSLDASFWNMQTLFRFETTAGSSTGVRSPGFASKLNLIAAILKFDPSRSPLTTALDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVB5</accession>
    <name>A0A194XVB5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_679325</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078436.1">
        <property type="nucleotide sequence ID" value="XM_018213848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVB5"/>
    <dbReference type="STRING" id="149040.A0A194XVB5"/>
    <dbReference type="GeneID" id="28823574"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679325"/>
    <dbReference type="InParanoid" id="A0A194XVB5"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KUJ24081.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="612" mass="67680" checksum="FE335CAD17EBA4B5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWA8</accession>
    <name>A0A194XWA8_MOLSC</name>
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        </submittedName>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <location>
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            <end position="52"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="469" mass="51740" checksum="C263069907132C23" modified="2016-10-05" version="1">MATLQDEKVEDVCHLEQTETFVIDPVEEKKVLRKIDLYLMPSIFILYLFSFIDRSNIGLAKVAGMQKDLHLNSNEYYLAVIMWVIGYAGAAVPSNMILSRVRPSYYIPVIMFAWGAIAAGLAGVKTGTQLLVLRFFLGVFEAGFNPSVLFMISIWYRRHEQSKRFMIFLSAGILSGAFGGVFAGAITSRLDGAHGIPGWRWFFLVEGVATVGASLIVHWFLLDYPSTSKQLTPAQREIASRRLFLDGITHQKTEGGDLSAIGHAFVKVILNWRIWMLCPAYMTIIGALAISNFYPTLVEGLGYTSTNAQYMTAPLYLVALVIAIPASWYADRNPHLRGYLLNFTLILLGGLFSELTAGILDFKARYIFLCLINSAIWTGNCLGLSFTSTALGGCDTEVRAIALPLINGCGGLAQLYGSALFPAEEAPRYLIGFSVFAACFVVGGMIYLAAVFLFKNFPFVRSSTLENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2D8</accession>
    <name>A0A132B2D8_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">Multidrug transporter</fullName>
        </submittedName>
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    </gene>
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211315.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="28821041"/>
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    <dbReference type="InParanoid" id="A0A132B2D8"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="240"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="327"/>
        </location>
    </feature>
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        <location>
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            <end position="614"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ06565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="627" mass="68702" checksum="AF97E92A2F220181" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2U9</accession>
    <name>A0A132B2U9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060928.1">
        <property type="nucleotide sequence ID" value="XM_018216529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2U9"/>
    <dbReference type="GeneID" id="28826255"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692388"/>
    <dbReference type="InParanoid" id="A0A132B2U9"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="272" mass="30358" checksum="5E9B41867C07E90F" modified="2016-05-11" version="1">MSWMDSWSRPGKHAAIPPPLYSTQGDSARYCQSCGRIMSSSAKAGTAKLEEKKYCSSRCRSQKPGPQDRRIEDAFVRLLMADSKFEREPIPEALLNKRTKPLKGDPRVIVPCSVVEELIFGTRHDPTKTSGRKKNRASRVIGDENEELDGHGAELKQFTTQGFAGKVRPPQHLTDINGSIGGEKGRAEKGEETGEHAGRRKEGLRVTEEKERVKRAARRGVVFGFTVGDAKEAESEDKGNDHHARRKCEAMMKGKVVEPSFAKGDWGIRWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B317</accession>
    <name>A0A132B317_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_661593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060998.1">
        <property type="nucleotide sequence ID" value="XM_018212612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B317"/>
    <dbReference type="STRING" id="149040.A0A132B317"/>
    <dbReference type="GeneID" id="28822338"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661593"/>
    <dbReference type="InParanoid" id="A0A132B317"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30921" checksum="A5BC4C53256D76B3" modified="2016-05-11" version="1">MVRHTLEYPKDIHNTVNRYKHQAVYSLTTIHTFINTTPVLHANTNLHKVSFSPSPEDPFPVILPLIGQMGSFSRPSASLGDPLECYLHGYVSSRIMNLSRASGGKGLPICIAASKVDGLVLTLTPNSHNYNYRSAVLFGHATLVEDLDEKLWAMELITNSVVPDRWRHTRLPPNAAEMQSTQILRVKIDSGSAKVREGVPNDEKGDLGNKEVLGSVWTGVLPLYEQFGEPVPGPYNEVAEIPAHVLEYRESLNKRNFEYAGAAARKDAPVKKKEPGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B351</accession>
    <name>A0A132B351_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_661399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061175.1">
        <property type="nucleotide sequence ID" value="XM_018212601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B351"/>
    <dbReference type="STRING" id="149040.A0A132B351"/>
    <dbReference type="GeneID" id="28822327"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661399"/>
    <dbReference type="InParanoid" id="A0A132B351"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="456"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ06820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="538" mass="57359" checksum="BBDBC4C43959C220" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B362</accession>
    <name>A0A132B362_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_790498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060834.1">
        <property type="nucleotide sequence ID" value="XM_018223376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B362"/>
    <dbReference type="FunCoup" id="A0A132B362">
        <property type="interactions" value="1233"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B362"/>
    <dbReference type="GeneID" id="28833102"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790498"/>
    <dbReference type="InParanoid" id="A0A132B362"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
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            <begin position="127"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger H2C2-type histone UAS binding" evidence="3">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF09337"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="554" mass="61271" checksum="B68A0021804698DD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ07976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22848" checksum="07D5D2DA83953F56" modified="2016-05-11" version="1">MPSIAQNATRAAGLFQEILVAPHQGEAPKKDIQDLSESKISDILERYQIWAASVGAYVENNNSLEYRLRNAPKVEAQIVELLSDISESLEDACQIITSAKENHTASKLRRTESSDDNLNSISIDPNIDTSVLEQGDSEIREIFESMEDALEHLFRLCNIIRDISKRDNSSQVTDIVASPHEEQLDRDHVMDMFPKLEFHGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6G9</accession>
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            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
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                <person name="Frasz S.L."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="96" mass="11087" checksum="02225990C3B23125" modified="2016-05-11" version="1" fragment="single">DAQTYQIYRDVLCRQSPFFAGAFEGETLKDGRLSITLDDVGPEEFGIFVHWLHYRVIRGKSNDSTIAISTLINLWILGDRFMVPQLCNDVMDILYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B789</accession>
    <name>A0A132B789_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B789"/>
    <dbReference type="GeneID" id="28820992"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_631101"/>
    <dbReference type="InParanoid" id="A0A132B789"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="97469" checksum="555A8AFB83A4AA7F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B854</accession>
    <name>A0A132B854_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_788948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062945.1">
        <property type="nucleotide sequence ID" value="XM_018223212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B854"/>
    <dbReference type="GeneID" id="28832938"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788948"/>
    <dbReference type="InParanoid" id="A0A132B854"/>
    <dbReference type="OrthoDB" id="3472778at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25995" checksum="5E8848BA4E50AFFA" modified="2016-05-11" version="1">MKAKKVLAKPRKRQKGGFPVDKVLQKAGRDLENYPNRLDVNQPWGWEKHLDLFPQWLWLSDQWIEADEQATSDLWVQYVEAVQSQEEVPSLKLAPLGGIPDFLNQHELEGTMKYQNGPFVVDYLDGNQQQVAPDALLKYIPPGRFWIGLNVPDKRCVPLGAGVFIGFRRLGRPEKNPWWWECVYARLDKRGHLYLHAYNYNYSGMPLTSRKNYRSRARTQNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8N9</accession>
    <name>A0A132B8N9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_690776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063120.1">
        <property type="nucleotide sequence ID" value="XM_018216167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8N9"/>
    <dbReference type="STRING" id="149040.A0A132B8N9"/>
    <dbReference type="GeneID" id="28825893"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690776"/>
    <dbReference type="InParanoid" id="A0A132B8N9"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="35808" checksum="8029B305627054B0" modified="2016-05-11" version="1">MSPNNFAAVLPVAQGTITVGPVDYPTLPPGGVILRNTVVAFNPVDWKIARNGNRPIEYPAVLGYSYGGVVEAVDEAVSRVKKGDYVFTHNPKAGGFQRFSAADATFVGKVDEKSVEETAAVVLNLRTIIGAAVEAGLDRPKDTTTANPSNGKKALVYGGSSSLGALAIQYLVQAGYTVISTSSPANHALVSGFRAAVVVDHTKSADDVVAALKKHGPYDFAFDAISTAPATAINAAVLGAQSGDIVLYSVGPPPADVDIPKNVTRVVKGWPSSLAALDPSFDEWVFVKYIPEAVAAGTLKSVPLELIHGGLGAVDGALRKLEQGVSAQKLILYQWEDAPKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B970</accession>
    <name>A0A132B970_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_630029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062572.1">
        <property type="nucleotide sequence ID" value="XM_018211227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B970"/>
    <dbReference type="GeneID" id="28820953"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630029"/>
    <dbReference type="InParanoid" id="A0A132B970"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="46434" checksum="9A1B64D56B9C6252" modified="2016-05-11" version="1">MTINIAIVGGGIAGLCLARGLVRHPHLQVTVYEATQRYLDIGGGLAFHGNAMRALELIDPELQAEYFRRATVMNERDVEMATQVLVGDAVAEDGGSVLLAELGKAKGRKTVARSDLLEGLLSLIPGGVVKFGKRLAQIEEKSTNGAIGATNISLTFKDGTTATADVVIGCDGVHSVIRKYLLGADHPAVGLKNHDAWQWIRRSVPAEEVMKLNERLLSYVPIFCGHGAYMNCLPTHFGKTLNVAVVQISKDSRLTVSSEKDGVQETPDIITPEAFSHWTKDARDIATLALRDPSTEWKLEDHDPAPFYSRGRICMIGDAAHATMPFNGQGAAQSIEDAALLTALFEHVTKLEQVEKALGVYDELRRPRTQKIAELSRQFGRMYAFAEEGVGDDLGKMRAILGAGAKYTNDVDLKALNEEAVRNFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAG4</accession>
    <name>A0A132BAG4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_741101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063741.1">
        <property type="nucleotide sequence ID" value="XM_018220663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAG4"/>
    <dbReference type="GeneID" id="28830389"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741101"/>
    <dbReference type="InParanoid" id="A0A132BAG4"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11124" checksum="2C77B19D2412050A" modified="2016-05-11" version="1">MASSIIERFDKLSLVADGQNHADSARTILATVYPRPGKTERIIELYQPILKDGATKEPGTIQFQLFVDINPETGNEEIFTIEKFKNLEALDCISRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB57</accession>
    <name>A0A132BB57_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_274343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063976.1">
        <property type="nucleotide sequence ID" value="XM_018206393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB57"/>
    <dbReference type="GeneID" id="28816119"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_274343"/>
    <dbReference type="InParanoid" id="A0A132BB57"/>
    <dbReference type="OrthoDB" id="3477009at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="37564" checksum="463A50BDB7EC2989" modified="2016-05-11" version="1">MDISEDVYVTSRSRTPSFIDVKSQSERVFTHLPDIIQEAIVSTEFSSPRLRISRVQDGILDTEYMTQPMFYITSRTDSGIDLPDLNVTDEKLLGKYGSDLTANFADIRAYGAKAFFEKENLSNGSKYSLCACATGYIWVSVTAVQQATSYPHLDDVEIQIGTYALKAKAITTVEIPCVYRCMSSDEPLGGEPALLFSTVLGNYLRNRMLGQQYEEATDNAIKTTRKELSSRQIMNPTLFGDFYSVLKEMCTNAPLPPTSDVSLISRSMITRRWQCWRESSILRKRYFFPQRIIRCLKPSRHDSIDLLSGCYMALASEKARSKVVSTEAVEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCP4</accession>
    <name>A0A132BCP4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_597005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064555.1">
        <property type="nucleotide sequence ID" value="XM_018209958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCP4"/>
    <dbReference type="FunCoup" id="A0A132BCP4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="28819684"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597005"/>
    <dbReference type="InParanoid" id="A0A132BCP4"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="418" mass="47406" checksum="710748211C3E921D" modified="2016-05-11" version="1">MTIRERRKASLEAEGYKDLSQDATRLLADGYAARRTRRKRNWYNYCIFGGISGLTILAFLLVLNLLLGVATLLWTSDLDHVLQNWGQPGTGTEGLAWYPTDFTRDILPIPCHSHNDYWRRVPLFSALRAGCTGVEADVWLFDEELYVGHNTASLTRNRTFASLYVDPLVKILEDQNSSSDFYNGTSHGVFDVDPGQSLTLLVDLKTSGAETWPWVLKQVQPLRDRGWLSFMENDTVHTRPITLVGTGNTPFDVLTANSTYRDAFFDAPLDTMWEARRVTPEMQSWPKFDDSLPGERLDEEEGSAEEKLPTSSSETQDLGQGLSGTLPDTEFNPLNSYYASVSFGKAVGRIWRGRLSPRQMKIIRGQIRGAHRRGLKARYWDLPAWPLGLRNHVWDVLVREGVDYLNIDDLRGASKQVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCW2</accession>
    <name>A0A132BCW2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_657898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063852.1">
        <property type="nucleotide sequence ID" value="XM_018212450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCW2"/>
    <dbReference type="GeneID" id="28822176"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657898"/>
    <dbReference type="InParanoid" id="A0A132BCW2"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="22906" checksum="0D21C3C75B7DAC4F" modified="2016-05-11" version="1">MTRKKKSKPVEGKGIVHTKRREVVYEDGWTLIVDTPKAKTIPKPTFHGGDFEVNGVSYINRTLDEMRADFEHWKKAWEESDACGALREKLEGMKIENAVVLGLGSLQSSRREGRRASATQLAALQTVLGALDLPVVLQDPQYTELDKEFLTSLGYKVVDDPGAFAAVGTGSLVYAIHCYGPVYQSFSDGPRPAVLIGTDVENFGRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD98</accession>
    <name>A0A132BD98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_740083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064713.1">
        <property type="nucleotide sequence ID" value="XM_018220545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD98"/>
    <dbReference type="FunCoup" id="A0A132BD98">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BD98"/>
    <dbReference type="GeneID" id="28830271"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740083"/>
    <dbReference type="InParanoid" id="A0A132BD98"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17639">
        <property type="entry name" value="LC_FACS_euk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="696" mass="76691" checksum="DC8BCD33A4C8C983" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDP5</accession>
    <name>A0A132BDP5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_596363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064891.1">
        <property type="nucleotide sequence ID" value="XM_018209918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDP5"/>
    <dbReference type="GeneID" id="28819644"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596363"/>
    <dbReference type="InParanoid" id="A0A132BDP5"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="29890" checksum="EFB4658C18266718" modified="2016-05-11" version="1">MPSYHYGAKIPVTCLNRSIDTGEHISNEKNELEYIPFPICEETGKPLELQYGIEDELNCTIPMITDPFFHLLEFYVHNDAPLSCRIPSRPPAHILPGGETHIPPEFQQEFVPLVFALAGTLQLSHLHISTHLNILLHSEPKHHLHHHDSGVIDSGAAYSTSPLSHITGPAALTKKLVIGDPLPLQFSIRWFPTPHLPRENGKIEWAGIGGHFYASTFFYCVISAMAGAVGSGMWFFGVVLPRRLKGRPLGGATPLGYGVGNGWGVGAGVGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE47</accession>
    <name>A0A132BE47_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_656750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064469.1">
        <property type="nucleotide sequence ID" value="XM_018212400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE47"/>
    <dbReference type="GeneID" id="28822126"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656750"/>
    <dbReference type="InParanoid" id="A0A132BE47"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="41616" checksum="EF46B8B8B81D6AFE" modified="2016-05-11" version="1">MPKQVIVQSSIEAVEIIDTPIPTPQHDQIVIKVIVSGTNPKDWKYPVWTGNPQNSGDDIAGIIHSVGKDVYEFKPGDRVGALHEFFTPDGSFAEYAVTRDYATFHLPPHVSFEEAATVPLAALTAAIALYADMKLPPPYYPVKSLAEGGERIPLLIYGVTSAVGAFAAKLARLSGLSPIIGISGRAGDYAKTLVDYVVDYRNGEDELVAAVEEVLAKEGLGNKIHYVLDAISENGSLEATLRFLAPEGTVSTVLPTKLFARDKENFKWPSSTKSFNSAIPLVFSTHKDFGYLWSRYIARMLEDGRLKGHPYEVIPGGLNGVLTGLQNLKNGKASAVKYVYRIEDTKNVPNQGVTGKLGTEEQESKDQPAEKAHPLRNFPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRC2</accession>
    <name>A0A194WRC2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_655253</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064946.1">
        <property type="nucleotide sequence ID" value="XM_018212337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRC2"/>
    <dbReference type="FunCoup" id="A0A194WRC2">
        <property type="interactions" value="1024"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRC2"/>
    <dbReference type="GeneID" id="28822063"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655253"/>
    <dbReference type="InParanoid" id="A0A194WRC2"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="137" mass="14857" checksum="DCBE6F79151C7340" modified="2016-10-05" version="1">MPPKAAAEKKPASKAPASKAPAEKKEAGKKTAATGDKKKRTKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSN4</accession>
    <name>A0A194WSN4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_595653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065325.1">
        <property type="nucleotide sequence ID" value="XM_018209873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSN4"/>
    <dbReference type="GeneID" id="28819599"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595653"/>
    <dbReference type="InParanoid" id="A0A194WSN4"/>
    <dbReference type="OrthoDB" id="10571839at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11744" checksum="72C46303B2B9DB63" modified="2016-10-05" version="1">MRTFATSSTRDLLDTSVDEYTRANYEDPAFEGLREQGAILWITFDWDMKTFKATAWMPDAVLHMMKASKWECGLTRMDTWECLYNDSPFVRGVVGKGECWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT56</accession>
    <name>A0A194WT56_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_544025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065162.1">
        <property type="nucleotide sequence ID" value="XM_018208217.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT56"/>
    <dbReference type="STRING" id="149040.A0A194WT56"/>
    <dbReference type="GeneID" id="28817943"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_544025"/>
    <dbReference type="InParanoid" id="A0A194WT56"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="161" mass="17117" checksum="F85FD81C93318CEA" modified="2016-10-05" version="1" fragment="single">PLHYAVAEGNVELIEALLDAGADIEIQEGKSGKTPLLKAVSENQPQALATLLVRGASQNVRSGFLNRLPIHEAAEEGYLAICSLLLKHGGEVDSRDSLGQTPLHHATCLGIIPILMEHKASINKADSTGRTALHGALRGKWPKLATLLISYGADEDLADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTD9</accession>
    <name>A0A194WTD9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065583.1">
        <property type="nucleotide sequence ID" value="XM_018215848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTD9"/>
    <dbReference type="FunCoup" id="A0A194WTD9">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="GeneID" id="28825574"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689128"/>
    <dbReference type="InParanoid" id="A0A194WTD9"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="40716" checksum="0DAA4436BA9256AB" modified="2016-10-05" version="1">MSSTLFKPLKLGNLQLQNRLVLAPLTRFRADDNHVPLSFVPEYYAQRASSPGTLLITEATFIAPQASGYGNAPGIWSQAQIEGWKKVTAAVHEKHSFIFLQLWALGRASNPKQLKKEFGDKYEVKSASDIPFEGGAKPTPLTETEIKEYVGLYAQAAKNAIAAGFDGVEVHGANGYLIDQFLQDVSNQRTDSYGGSIENRARFGLEVTKAVVEAVGAEKTGIRMSPYSSFQGMGMKDPVPQFSYYASELKKLKLAYIHVVESRIEGNAEVESTEKVDFLIDVWDNQSPVLIAGGFTAASAKTAADEEYKGKDIAIVFGRHFIANPDLVYRIKNNIEFTPYDRNLFYNKGEKHGYIDWPFSKEFTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU75</accession>
    <name>A0A194WU75_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_595114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065517.1">
        <property type="nucleotide sequence ID" value="XM_018209843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU75"/>
    <dbReference type="GeneID" id="28819569"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595114"/>
    <dbReference type="InParanoid" id="A0A194WU75"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="64878" checksum="096A9283051D47A9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUN4</accession>
    <name>A0A194WUN4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_786556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066028.1">
        <property type="nucleotide sequence ID" value="XM_018222995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUN4"/>
    <dbReference type="STRING" id="149040.A0A194WUN4"/>
    <dbReference type="GeneID" id="28832721"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786556"/>
    <dbReference type="InParanoid" id="A0A194WUN4"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17898" checksum="7A008AE6BC445E86" modified="2016-10-05" version="1">MTASTSHLSETSVASSPTKGRYLCLTICGYRKPGMSEEDYRNHMVNISAPMTKDLMVKYKIKRWTQIHNQSATRALMAQLFDPQMCNVADFDCFSQVVFEDIEDYKRIKQDPWYKQHLIHDHENFADTKRSSMTIGWIEEFVRDGEVVDGFKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVC8</accession>
    <name>A0A194WVC8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_786514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065979.1">
        <property type="nucleotide sequence ID" value="XM_018222990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVC8"/>
    <dbReference type="GeneID" id="28832716"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786514"/>
    <dbReference type="InParanoid" id="A0A194WVC8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="212" mass="24926" checksum="F39682888CA0AD2C" modified="2016-10-05" version="1">METQDREEQAIKDRMADIQPKHFTQKQIIMSFGYANIHTFMRAHRLKFSDFQHYEQAQTMIEQQRYNLQSKWEQDRDMEELTMETVTGLPTDSQSPLMVTTREHNKNIRDQMSLEQELMELGVMMGGSSLQAVRLEKEDVLFRYVDKERERASRKARGLKKSSSRQKEDIEWTVRPTLKADGPTSRGRSREPKTIQREASTYVSFADLIDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXS5</accession>
    <name>A0A194WXS5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_652079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067136.1">
        <property type="nucleotide sequence ID" value="XM_018212187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXS5"/>
    <dbReference type="GeneID" id="28821913"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652079"/>
    <dbReference type="InParanoid" id="A0A194WXS5"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267574" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="380"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="990" mass="108218" checksum="6B8D909525447CED" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXX7</accession>
    <name>A0A194WXX7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Xyloglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_737733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067181.1">
        <property type="nucleotide sequence ID" value="XM_018220291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXX7"/>
    <dbReference type="GeneID" id="28830017"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737733"/>
    <dbReference type="InParanoid" id="A0A194WXX7"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000534">
        <property type="entry name" value="Xyloglucanase Xgh74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267584" evidence="9">
        <location>
            <begin position="25"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="814"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="778"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="853" mass="89608" checksum="D9EFED6D1E666A3D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYY7</accession>
    <name>A0A194WYY7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_709092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067520.1">
        <property type="nucleotide sequence ID" value="XM_018217734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYY7"/>
    <dbReference type="STRING" id="149040.A0A194WYY7"/>
    <dbReference type="GeneID" id="28827460"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709092"/>
    <dbReference type="InParanoid" id="A0A194WYY7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF4">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="60055" checksum="E4A77C14268FC9C8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ70</accession>
    <name>A0A194WZ70_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_753811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067600.1">
        <property type="nucleotide sequence ID" value="XM_018221294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ70"/>
    <dbReference type="GeneID" id="28831020"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753811"/>
    <dbReference type="InParanoid" id="A0A194WZ70"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="24709" checksum="BA96578A34952DAB" modified="2016-10-05" version="1">MHFLCLHGAGTNNKIFDLQTATLRHELGDHHTYEFVEGTVPWPMAPGISSISNSGESYYSYFDPEAPTSVLDALHSLDAYIQAEGHFDGVLGFSQGAYLAAIYVVWKAQQDGTTEFRLPFSCLLLFSAVRVHNPRAFEERGEIEVLDPNLAKEFIQIPTVLIWGSSDEWKEESVALSKLCNPRLTTVFVHSGGHEIPGMVAKGDITAVVKAMRRGIFEAQFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZM1</accession>
    <name>A0A194WZM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_721414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067745.1">
        <property type="nucleotide sequence ID" value="XM_018218648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZM1"/>
    <dbReference type="GeneID" id="28828374"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721414"/>
    <dbReference type="InParanoid" id="A0A194WZM1"/>
    <dbReference type="OrthoDB" id="3565214at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="183" mass="18590" checksum="8A5053D18E845C76" modified="2016-10-05" version="1">MLEVFSTSDLVESLCLLNFSPNLIVSASNQYIPSQTSFSFTIYLLPSVQPSHINMHFSTLPLLTLLLAQATAHNAPEKRQWQSIVESATSVAATIGNGYNSIGQSIASSADSVAATAADSATSRASVIVSSANSVAATAGDSATSRASSVVSSALSVASTAADSATMEASSVFCGVVGEFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZQ1</accession>
    <name>A0A194WZQ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_737402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067775.1">
        <property type="nucleotide sequence ID" value="XM_018220247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZQ1"/>
    <dbReference type="GeneID" id="28829973"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737402"/>
    <dbReference type="InParanoid" id="A0A194WZQ1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267736" evidence="1">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="93" mass="10158" checksum="AD115D1EE17E4806" modified="2016-10-05" version="1">MHTSLLSLLLATTALAFHCTKPTYSPACCDSVYTSGVKDGKFEGKDCYQAFPTSFDVPVNERNYTCEIADTIPGCCKGDKKEERRSHCVGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZR4</accession>
    <name>A0A194WZR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_672649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067790.1">
        <property type="nucleotide sequence ID" value="XM_018213295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZR4"/>
    <dbReference type="GeneID" id="28823021"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672649"/>
    <dbReference type="InParanoid" id="A0A194WZR4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="21999" checksum="CFD5CE2E4605CD4D" modified="2016-10-05" version="1">MPLFRCPRLPTCKCSRHTSSALIVKSSPKQTRIVRRIDTLSIQDVLAAQNASKQRKSIASTGPPLCDADFAGLKPGIALKQHFIVIREWHMSDVLSAQNFSEIEQRVMYTRDRFITNVPIARRVSARKERKGVTSGGVTISTIIRSRAQTSNQLNDCVLTSTMEVVDHEGGEDGGWGPPVRHWTFRMRRRTENNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Z1</accession>
    <name>A0A194X0Z1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_672137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068216.1">
        <property type="nucleotide sequence ID" value="XM_018213262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Z1"/>
    <dbReference type="GeneID" id="28822988"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672137"/>
    <dbReference type="InParanoid" id="A0A194X0Z1"/>
    <dbReference type="OrthoDB" id="10567081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11280" checksum="AE36F1428FF1BCF6" modified="2016-10-05" version="1">MHGVTNSSQIEKRLALYEDIGRNRAASIQVLSSVGYDEPVPKAVAEYLEGRPVPNNMKEIIQLEYGDDVLLRTIEVMTEFDPTWNIPDGSFPAGYNSEAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X158</accession>
    <name>A0A194X158_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_737569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067952.1">
        <property type="nucleotide sequence ID" value="XM_018220275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X158"/>
    <dbReference type="GeneID" id="28830001"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737569"/>
    <dbReference type="InParanoid" id="A0A194X158"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07257">
        <property type="entry name" value="THT_oxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="162"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="36596" checksum="B3190A7618363546" modified="2016-10-05" version="1">MSPSATKQKINLKRIAHVYYQHKNLEAAHQFLLDFGFSPIQKTEDKIYYRGYGTEPFVICATKGAEDKFLGSGWVVDSMEDLELATSLPNATPIHDSDTPGGGKKVTFYDPVDNCPWHLVYEQTAVEIAETFPELSYNFPTSKHRPVNQKQRFKKGPAPVHKLGHYGLCVTDYKKAYEFYTANFNFKPSELVYAPDTGEDITTFLHLDRGSEWVDHHAFFFFEGPKFHVHHSSFEIFDFDIQMLGHTWLNEKGYQNCWGVGRHVMGSQIFDYWFDPSKFILEHYVDGDLVNDETPINKTKAGPGNLHVWGPEVPPTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2G3</accession>
    <name>A0A194X2G3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_699051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068377.1">
        <property type="nucleotide sequence ID" value="XM_018217027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2G3"/>
    <dbReference type="GeneID" id="28826753"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699051"/>
    <dbReference type="InParanoid" id="A0A194X2G3"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="272" mass="29037" checksum="826D7C5C5323F9A7" modified="2016-10-05" version="1">MLRLDGKVVLITGLGQTQAESDVLGIGAAIAVVFARQGAKVFGGNRSLTSGMVTKKMIESEGGICDVMETNVTSSDSVKLLVDACMKKHGRIDILVNNVGRSEPGCPATMSEEVWDSQVELNLKSVYLLCHHVLPIMEAQGSGAVVSIASIAGLRYIGKPQVGYSATKAAIIQFMKATAVIYAERGVRLNTVVPGLMDTPYTKAMVERYAKDGGSEEFMRMRNRQVPMAKMGDAWDVANAAVFLCSDEAKYITGQKIVVDGGITSSTGRPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2J7</accession>
    <name>A0A194X2J7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rab GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_620849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068758.1">
        <property type="nucleotide sequence ID" value="XM_018210925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2J7"/>
    <dbReference type="FunCoup" id="A0A194X2J7">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2J7"/>
    <dbReference type="GeneID" id="28820651"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620849"/>
    <dbReference type="InParanoid" id="A0A194X2J7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ14403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="22674" checksum="05362B71469A1C2E" modified="2016-10-05" version="1">MAGSRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFSNVEQHATEGVNKILIGNKCDWEDRRVVSTERGQQLADELGIPFLEVSAKSNINVEKAFYSLAADIKKRIIDTAKIDQSSPAGVDVGAQGSGNGLGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3M0</accession>
    <name>A0A194X3M0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Frequency clock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_539687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068979.1">
        <property type="nucleotide sequence ID" value="XM_018208148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3M0"/>
    <dbReference type="STRING" id="149040.A0A194X3M0"/>
    <dbReference type="GeneID" id="28817874"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_539687"/>
    <dbReference type="InParanoid" id="A0A194X3M0"/>
    <dbReference type="OrthoDB" id="2536795at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018554">
        <property type="entry name" value="FRQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09421">
        <property type="entry name" value="FRQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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            <begin position="1"/>
            <end position="101"/>
        </location>
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            <end position="923"/>
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        </location>
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            <begin position="13"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000070700"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="104237" checksum="D2A64D284B9E73AA" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X467</accession>
    <name>A0A194X467_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_621185</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ14607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="DUF3533"/>
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    </dbReference>
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        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12051">
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    </dbReference>
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            <begin position="35"/>
            <end position="58"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Pfam" id="PF12051"/>
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            <dbReference type="EMBL" id="KUJ14607.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="503" mass="56393" checksum="6D27233DF0D77A48" modified="2016-10-05" version="1">MALLQGYPKARDRSGRTKGHDSATRISRKAYFKAAGLNFLMLQVLFLGLFCYIFGAIFQQGPHTHNLNIVFVDYDNGVIGRSIRNAYAELQADTFPSLQERPAAQYPSPDQLTKAVCKTDFWAALYVAPGASQRLENALDGSSSAATYNRSDALTYIWNEARYPTVADSSLSANIETLSSAARVAYSAINGTGALQMLNTSDPTSITVFANPWQLSSVNLQPTTQGSRLIYNTLVIILILIQEFFYLGVINGLYAQFKFYVRFLPHRIILYRGLVSLAYTFCGSLCVTGAIWAFRAGWNVNGNQFALSWAILWLFAHVNFLWLDVFSVWLPVQFLPMALITWVVFNVASILLPFELSPGFYRWAFAMPAHEVYLTLIDIWSGGCNPHLSYALPIMFSLEVLGWFLSAVGVYRRCHYAVIAETAAQNAFQERLNAAMEFERKHDQEIREAMEGSQEVISEAKEREKMGEEIEKQETKMARDNRRASVACNFGPSFELVGSKSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4U3</accession>
    <name>A0A194X4U3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_698086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ15196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4U3"/>
    <dbReference type="GeneID" id="28826682"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698086"/>
    <dbReference type="InParanoid" id="A0A194X4U3"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="431"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="59499" checksum="7F556C09C3A4607D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5G6</accession>
    <name>A0A194X5G6_MOLSC</name>
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        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_708248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ15416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217672.1"/>
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    <dbReference type="GeneID" id="28827398"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708248"/>
    <dbReference type="InParanoid" id="A0A194X5G6"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="68"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="530" mass="57766" checksum="C5F1F904EEFA8B1E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5J9</accession>
    <name>A0A194X5J9_MOLSC</name>
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        <submittedName>
            <fullName evidence="12">Putative maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_708262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217674.1"/>
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    <dbReference type="FunCoup" id="A0A194X5J9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="28827400"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708262"/>
    <dbReference type="InParanoid" id="A0A194X5J9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
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    <dbReference type="InterPro" id="IPR005828">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR003663">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="16"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="58227" checksum="B96E1EB3F7AC4BC7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5U7</accession>
    <name>A0A194X5U7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_698282</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069911.1">
        <property type="nucleotide sequence ID" value="XM_018216969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5U7"/>
    <dbReference type="STRING" id="149040.A0A194X5U7"/>
    <dbReference type="GeneID" id="28826695"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698282"/>
    <dbReference type="InParanoid" id="A0A194X5U7"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70470" checksum="6F945E020B6048FD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X666</accession>
    <name>A0A194X666_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_586997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070031.1">
        <property type="nucleotide sequence ID" value="XM_018209399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X666"/>
    <dbReference type="FunCoup" id="A0A194X666">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X666"/>
    <dbReference type="GeneID" id="28819125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586997"/>
    <dbReference type="InParanoid" id="A0A194X666"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="48567" checksum="473CFE80592EE805" modified="2016-10-05" version="1">MWFFRVLSSAIFLLSIILSIPIAFDVGGRDCGLAFSLSLFYFYFFYSTIRLATPDKSRVRWALVQMIGMAQWVLIPGLLIWSMNRFAVDANNSGDWVARTFDGKRAQHSTIREWIFGSGGLLEMMTIGTWDKLLRYSTPFFQLAEGFCSLLVIQAAGQITRWLVNRGRSDMWMIGLLVLSASIISSSVYFLWRIMNFPEIGNVDATLIGVTITCAVFLCAWGIGSGRGNPVESSLLFAYVVLCIYQIFTDYLPTSEPPPPPAQPDFPPFPPIIMASYSTLVYILSTLPSAVLSGFQFLYAAFQTITPSVIISLAYRIFVFYSATRIIPAVRESGARALSQEPSLEDSDGAGKILGLLSWFSPSILVAVYTSLLMQHFSTTSAEGNNTEWWMMQGGDAGGNVWRWINVAATMALYALELYLGKEESDDSLTSHWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6U1</accession>
    <name>A0A194X6U1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_98216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070251.1">
        <property type="nucleotide sequence ID" value="XM_018223555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6U1"/>
    <dbReference type="GeneID" id="28833281"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_98216"/>
    <dbReference type="InParanoid" id="A0A194X6U1"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="446" mass="48386" checksum="3A12A83133DE8554" modified="2016-10-05" version="1">MMETAATAAAAVRGLFQSTHPINAKWERVKAPSLPRSSHSISVIAGRAYIFGGEINPREPVDNDMHIITLPYGESLESDYKALPAKPEITGGEVPEKRVGHTAAVIGERIFVYGGRGGVEMKPLEEKGRVWIYDTRSDAWSYLDPMPSTPVPETRSYHSSVAIAKPEPSNMKSMAVDNATEEPKASTIAEGAKTDEELGGYGTFFVHAGCPASGRTNDLWGFDVRSRTWKEFPTAPGKPRGGTSLAVSKQRIYRYGGFNGEGEEGGYLDYLELGLDTFNDKGGAGEMSVSAKGTWETLNFQEENMQYPGNRSVAGLQAITTGMGREYLVCFLGERDPSSQGHAGAGKFWGDVWAFQCPPQGMTAASFKDATWQALGRETGEGLWSPVMVSDAEGVEGEDVHKLVPSERGWFPSTTLGDLDASGILLWGGLNGKNEREDNGWILRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6V4</accession>
    <name>A0A194X6V4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_587390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070261.1">
        <property type="nucleotide sequence ID" value="XM_018209427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6V4"/>
    <dbReference type="STRING" id="149040.A0A194X6V4"/>
    <dbReference type="GeneID" id="28819153"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587390"/>
    <dbReference type="InParanoid" id="A0A194X6V4"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="371" mass="41291" checksum="5495613B76FDD880" modified="2016-10-05" version="1">MRQRRYQSNKSFTNSFKTLFRTYPFSVSAAVILIGIGATALLYVNDFYHNYIIGAFHKFPPPVAKELRKALYYTNISLEPKNAVKYYKEALRVADEIGMDPFSDEIIGVKIQLAALMEKLQLYKKAIDILEIVKRDNLRWVDELGNLPGNEGKRTRVLGKTVGISVKLGELYANEYVKEKGAAEERLVWAVETVLKEQQRRESEGVKPGEGEWLSPEEIGGSLEALGHHYEEKDQHYLAAPLFLQALALSPPASCHTAVLMNNLSISLAQQDPPVTPNQTPISRPALISNARAWAEKAITTASKIQPPERTEECDMGCAVATHNLGEFAEMDGNIAEARKRFEEAKSLAKAIGFQDGVINSERGLGRLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7A3</accession>
    <name>A0A194X7A3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_101948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070401.1">
        <property type="nucleotide sequence ID" value="XM_018205011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7A3"/>
    <dbReference type="GeneID" id="28814737"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_101948"/>
    <dbReference type="InParanoid" id="A0A194X7A3"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="111" mass="12760" checksum="534AA0A6F7A1AE84" modified="2016-10-05" version="1">MTTEITRVTMIKIPEQYLDIALKGFETFTKNQKKDGEPYILSMAAGLAQGHVKEQGYTFVTKSVFKSKDDMEYYEKKCEGHLEYKKFLKENASVEGLMTCYFTSGVSWEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7I2</accession>
    <name>A0A194X7I2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_75342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070483.1">
        <property type="nucleotide sequence ID" value="XM_018221276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7I2"/>
    <dbReference type="GeneID" id="28831002"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_75342"/>
    <dbReference type="InParanoid" id="A0A194X7I2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8648" checksum="FA6151038929AEC7" modified="2016-10-05" version="1">MIVMRSYLTINFGAWRLGGSITAWRSRLSMDGIPLGCSNQRDRAHALQLVFSDTRLHMFSIQPFQSYMSDLTDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X818</accession>
    <name>A0A194X818_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_719620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070302.1">
        <property type="nucleotide sequence ID" value="XM_018218509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X818"/>
    <dbReference type="GeneID" id="28828235"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719620"/>
    <dbReference type="InParanoid" id="A0A194X818"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="341" mass="39645" checksum="924C17BD8D93D597" modified="2016-10-05" version="1">MTPKENNATEIAAPSKKPLSPSQELATFSHYQAYHFSLDPFELSLARLKITGRTRRERSSIRTEMQRDWNAMYYTAKITLERNLGYPECDGKEEMEFEDHPTDINRNQKWNEFLKSNTDRKVKRAEELEKISVEDLRIGFEHLEDLYLQADAGSKCKGLSGLREHIVTIRGKAQAGDSTNFKRRERIVIFLRKLRTCSEVDVADRDARHTEVWTRMHRWALDRWTYNLTYEDCRYVPSEKTPNEKHTYSKYVVEKLEEVDGLEPWRIHEKIQVKLDEVRDKLYEAQDLYLNENLEKEEARYISLAINSVNLGESGRISAAAMANYGAFCGEGGAYIPSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X887</accession>
    <name>A0A194X887_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_82571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070738.1">
        <property type="nucleotide sequence ID" value="XM_018223434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X887"/>
    <dbReference type="GeneID" id="28833160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_82571"/>
    <dbReference type="InParanoid" id="A0A194X887"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="21820" checksum="FAA00DC2407E1DB6" modified="2016-10-05" version="1">MAITGSMADPSWWLLPSFDLSHLGRPVGPSRGSLWCLEKVRGCMASIIRNTWHASEHQQKITMLRVFFYRDHLCISDACYAHAMPTSGMLDRLRGRVCSPIKFESLRCLNGQSTQVDFGSILFQPAKLTPVQYSISIHLPGLPVEVSLSLAFLVTCYFLIASTAKKDPEQNLLLARDPFRPLPARSNSRPSWVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X890</accession>
    <name>A0A194X890_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_685381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070740.1">
        <property type="nucleotide sequence ID" value="XM_018215071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X890"/>
    <dbReference type="FunCoup" id="A0A194X890">
        <property type="interactions" value="1338"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X890"/>
    <dbReference type="GeneID" id="28824797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685381"/>
    <dbReference type="InParanoid" id="A0A194X890"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="30"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="296" mass="32022" checksum="6DB6FADA7AA739D7" modified="2016-10-05" version="1">MANVPVTEIPTVSLLYRLKKLAPAQFQDESERPQPSQSFNDRIGLIRGDITKLEVGAIVNAANNSLLGGGGVDGAIHRAAGPKLLKECRRLKGCDTGSAKITGAYELPCQKVIHAVGPVFNSRFEQECAEDLAGCYTTSLELAVANKCKSIAFSALSTGIYGYPSDEAAPVAIKAVKDFLEGEDGDKLEKVVFCTFVQKDVDAYNHWLPRFFPSTEPEAEDEWEEVEGGESAENGPATQEEKAKDTEEAKEEKEAEKKEEEAPVELPDVPTTEPASESAEDGPATKKQKSGDEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8T6</accession>
    <name>A0A194X8T6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070884.1">
        <property type="nucleotide sequence ID" value="XM_018219926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8T6"/>
    <dbReference type="GeneID" id="28829652"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734629"/>
    <dbReference type="InParanoid" id="A0A194X8T6"/>
    <dbReference type="OrthoDB" id="10596942at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="197"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="31196" checksum="DEDD0628415E30C9" modified="2016-10-05" version="1">MPVTFPAGKIYLVHRSDYASHAEEGKITEIYGCYTTLVEATKRARAEVRALERECTPMRKMNVEYDPLFGAMVWVHDGGYADIEKSLISVQKMDIERYSEGEASDDEDFDDGDDEEPDSEGLGLQLESDEESEEEEEPEPESIIGIDPRPPLAPFSAHRQRQQDHEPTQTNNEPARVRTLYTPEAYPPPPPARVPARQIQRLAGRVFATAGTQRPLNRAAINSLIRTHGGTVVPLLPIRDQIQFVVLGDDVSVQMLNEMGEKGIAAMRQDQLLEILGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8V2</accession>
    <name>A0A194X8V2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TT1751-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070955.1">
        <property type="nucleotide sequence ID" value="XM_018215103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8V2"/>
    <dbReference type="GeneID" id="28824829"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685521"/>
    <dbReference type="InParanoid" id="A0A194X8V2"/>
    <dbReference type="OrthoDB" id="5190258at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="19819" checksum="90139AF1F566C24D" modified="2016-10-05" version="1">MATFKAEKYEATRITIQSPNSFNQVLKNLYSSIRDPSRVDEWKKKAKSITSYSDESRKQFEDNVNSAIGPHGFMIFQEFDHGSWIPLFNVGSGLKSKRIILGNPLVAITMLKHDITAGLAVPVEILVRELEKGGRTEVLYNLPSGLIAGLNDNEELRAAVEVLDRKLERLVREVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9G4</accession>
    <name>A0A194X9G4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_567489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071119.1">
        <property type="nucleotide sequence ID" value="XM_018208556.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9G4"/>
    <dbReference type="STRING" id="149040.A0A194X9G4"/>
    <dbReference type="GeneID" id="28818282"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_567489"/>
    <dbReference type="InParanoid" id="A0A194X9G4"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="229" mass="23538" checksum="3692C532F1AC39F7" modified="2016-10-05" version="1" fragment="single">SSNGSLPASSGTSALSAVQTIAAGDSFDGGMVMYDRGVSCTGQSEGGDSDAVFQIENGGSLSNVIIGPNQIEGVHCQGACTLTNVWWSAVCEDAFTIKNQDAGETTKIVGGGAFGAEDKVMQHNGGGTLSISDFTVETFGKLYRSCGNCDTMYERHVIMDGITATDGSELAGINSNYGDSATITNSALTDVSDVCVTYTGTDDNDEEPVENGSGNDGTYCIYGSDVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAC0</accession>
    <name>A0A194XAC0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_707443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071470.1">
        <property type="nucleotide sequence ID" value="XM_018217609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAC0"/>
    <dbReference type="STRING" id="149040.A0A194XAC0"/>
    <dbReference type="GeneID" id="28827335"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707443"/>
    <dbReference type="InParanoid" id="A0A194XAC0"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="454" mass="49595" checksum="4BC6DF31D0238FF1" modified="2016-10-05" version="1">MTQSHLPFPVPVPNATIPFWRTNPHPLDTHRSTASLPQKTDILIIGAGYAGISTAYHLITSSSSSPPPSIVLLEAREICSGATGRNGGHLRPSVPFPELIEKYGIAACLEIVLFEIAHMDAMKSLIEKEGIVCDFTLTGGHTVTKDPATVEFMKDVLGRYIAECPDLAEDYTVVVGEEAEKQSGVKGVIGDWQHEVAHLWPYKLFAGLLEICVKRGVNLQTNTAVLKSGGRDEEGYWGFETERGDVRAKKVVFATNGYTAGLLPEYKDVIAPRKALCTHIVVKPSAEDGKVKRMGNGWDSTYIIEPPLGGFDYLIQRPDGGVVVGGANRTYKEDGSGLGDWDDSSMIKPAEGYFEGYLERYFSTFKKGEDEETVDMAWTGIQGHTPDSLPHIGAVPGKEGQFIIAGFNGHGMPVIHLSSKGLVEMIVEGKKFEETRIPKLYEATKERLGVKFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAN5</accession>
    <name>A0A194XAN5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_669617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071564.1">
        <property type="nucleotide sequence ID" value="XM_018213110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAN5"/>
    <dbReference type="GeneID" id="28822836"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669617"/>
    <dbReference type="InParanoid" id="A0A194XAN5"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="35533" checksum="E08B1752392F2D10" modified="2016-10-05" version="1">MPKTAADVSLIVKALFKSNERFAIKAGGHNPNRHFSSVESGILINLRDLKEITYDAASSTVRIGPGNRWADVVKALELFNVTVVGGRIGSVGVGGYLLGSGGNMIFHSKKTDQILTAVRNFVEDCQDPRAAIIATNFLVLRAHVSFWAIFLFYDGPQPPPGTFDSFTEIGPMRETCRTTTYVKLLTKFDNFIFTGQSYSIATETSPLPDRKCGLKVMRSYYDSLDRIVMEFDMSNLRPSQASRVDAALVEIYAGIREKVQGFIADGTLPDAHLPLFMNDANYQQDYFGRLRPETLAFAKAVRDEVDPDGIFRERTGGFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAY1</accession>
    <name>A0A194XAY1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_584199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071659.1">
        <property type="nucleotide sequence ID" value="XM_018209255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAY1"/>
    <dbReference type="GeneID" id="28818981"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584199"/>
    <dbReference type="InParanoid" id="A0A194XAY1"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="925" mass="102659" checksum="1F76FF18381A3763" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB04</accession>
    <name>A0A194XB04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase class C and other penicillin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_718066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071708.1">
        <property type="nucleotide sequence ID" value="XM_018218391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB04"/>
    <dbReference type="STRING" id="149040.A0A194XB04"/>
    <dbReference type="GeneID" id="28828117"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718066"/>
    <dbReference type="InParanoid" id="A0A194XB04"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="16"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="46310" checksum="20ED21808BA8A982" modified="2016-10-05" version="1">MAAETFEQRVERACNDLEIPGLVMVAGDRDGKFYYEKAIGNRSLKDGKPDPMPLDATMWLASCTKLITSVAVMQCVEKGLLKLDDDVSTILPELKDMDVLVDFETGPHGKDKPVLKKNTKTVTLRNLLTHTSGLSYDVFNPVLMRYRATQGIQPSLYVTRPPKEAFHFPLLFQPGEQWEYGVGLDWAGWMVERATGVNLEEYFKKNIWGPLGVKSMSFYPNKNPAIKSKLADMSIREGGITMFGNPAEPNGKTIYIDDNIYSLDMTESTGGSGLFGAPLDYFKLLQSLLRNDEKVLKKGTVDDMFKPQLSPAQISSFEAKLAIPEVNVQMSDLPAGTKVDYGLGAGLIKNDIPGRWKAGTLFWSGYPNLHWYIDRESGIAGMIGSQLHAPGDPKFVEYAKLWGEEMFRQRGKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBG6</accession>
    <name>A0A194XBG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase C-terminal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_697321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071457.1">
        <property type="nucleotide sequence ID" value="XM_018216890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBG6"/>
    <dbReference type="STRING" id="149040.A0A194XBG6"/>
    <dbReference type="GeneID" id="28826616"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697321"/>
    <dbReference type="InParanoid" id="A0A194XBG6"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="100"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="232" mass="26839" checksum="20BAEF2F301A6A19" modified="2016-10-05" version="1">MAEDKTNPQFTLYTHHTCPAAFKVAHILSLLHLTYKPIYITITKTTKDQKEPWFLSLNPNGRLPVLIDHHHSNHIIWESASIITYLLTLYDPLFTLHPSSPFLQSEVNSWVALQVSGQGPTIGQAFWFGYWHSEILPSAYNRYVEETKRILGVLEGRLEGREWLVGNKMSVADVGFLAWYEEAFMVDIEIEREFPRCWGWIGRMKVVPEIVEGSVGREMIAPRKLWERGVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC99</accession>
    <name>A0A194XC99_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_733231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071732.1">
        <property type="nucleotide sequence ID" value="XM_018219777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC99"/>
    <dbReference type="STRING" id="149040.A0A194XC99"/>
    <dbReference type="GeneID" id="28829503"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733231"/>
    <dbReference type="InParanoid" id="A0A194XC99"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="456"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="931" mass="104378" checksum="1990CF77ACB3D6B4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD58</accession>
    <name>A0A194XD58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_732779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072441.1">
        <property type="nucleotide sequence ID" value="XM_018219730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD58"/>
    <dbReference type="GeneID" id="28829456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732779"/>
    <dbReference type="InParanoid" id="A0A194XD58"/>
    <dbReference type="OrthoDB" id="4499262at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268097" evidence="3">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="370" mass="37270" checksum="40BA6A8462285325" modified="2016-10-05" version="1">MAPLRLLTAIVSICLTAVIAQWGAMPGPGLSPRYFLGEAAHLVNRQNGDCPEPNEHTCLDVNAGSFCCPNTHYCIVANNTASCCYIGSTCSNPCDANHYECPSTTSISGTAVSTTSCCSRSCTSTSQYLCASALGGQCCSYNSGCATDTQCVATATSSNTVATTGSSSTCPTSQSPCANSLGGGCCDNGQTCTVADNTNYCASGTALVATRTGPNGILATAPSTLSSGLSTGAKAGIGAGVAVGALVVLGGFIWLYLGHRRRAKQAAIASAPAMSQGSESGTKRPSNGRSGSDYFGPTAAHGPFTEPHDSAATSPGAHRGVPVSPQSPGDIIVPVEIDSKSSRGHSNVTTPGAFEYVKPPSTTVDPVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDG2</accession>
    <name>A0A194XDG2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_41869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072568.1">
        <property type="nucleotide sequence ID" value="XM_018207389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDG2"/>
    <dbReference type="STRING" id="149040.A0A194XDG2"/>
    <dbReference type="GeneID" id="28817115"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_41869"/>
    <dbReference type="InParanoid" id="A0A194XDG2"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="60050" checksum="D2100F2DBA77F8B3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE64</accession>
    <name>A0A194XE64_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_36186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072407.1">
        <property type="nucleotide sequence ID" value="XM_018207001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE64"/>
    <dbReference type="GeneID" id="28816727"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_36186"/>
    <dbReference type="InParanoid" id="A0A194XE64"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19348" checksum="AC0F59642C5C1266" modified="2016-10-05" version="1">MLLRCPGDLKAAEVSSYNKLGRPDSTTKGISALFHIFILYPSFTSLHSLCSRLISSNIFFCSGSWFVVLPIRSLSHARWAGAISATQTQERAEKYAHQHDISSNLPVTESLFSPSTSTEPHDRPLSRYSRRANFFLLGTRMPETPFHPLPLDALACLPSRAYRIPFFFAKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFR4</accession>
    <name>A0A194XFR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ras-related protein ypt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_683819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ19008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073363.1">
        <property type="nucleotide sequence ID" value="XM_018214763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFR4"/>
    <dbReference type="STRING" id="149040.A0A194XFR4"/>
    <dbReference type="GeneID" id="28824489"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683819"/>
    <dbReference type="InParanoid" id="A0A194XFR4"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ19008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="207" mass="22824" checksum="E9A32E1903E053F4" modified="2016-10-05" version="1">MPPRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDFRESTIGAAFLTQTISLDDQTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKQWVKELQRQANENIIIALAGNKLDLVTAQPDKRAISTADAEAYAREAGLLFFETSAKTSENVRELFTSIAKKLPLDQAGPRNPRSGGRGGVELRPETPSQNNGPCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHC6</accession>
    <name>A0A194XHC6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_667165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073527.1">
        <property type="nucleotide sequence ID" value="XM_018212958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHC6"/>
    <dbReference type="GeneID" id="28822684"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667165"/>
    <dbReference type="InParanoid" id="A0A194XHC6"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="36009" checksum="43E0A468D1215E49" modified="2016-10-05" version="1">MASIASQDVADTPRQIHPTLDELKASAYDSPNIEAALEALHQDGFVVLKSVVDVDHVKNLNSFMAKDAEHMIKIKPFNQGVNSNILQAPPLKQPELLYNDVFFNPFVIQLMNAYLGSKPIWNFLTGNNALPKTNGLRQPVHKDITFFHPQCPFFVIANVPLCSFNPSTGSTEFWLGSHAHTAGRQQKITTPESKLANARLVVGDPMCDVLPDVIEERRKIRPPIQPSCEPGDIMLRDLRTWHAGMPNESENYRIMLALGYQAQWYPNHTLRVKLPLSQGNFFMKHGGQPVEVRADLLPDDVDFVKLNDDFTFRRSEGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHE7</accession>
    <name>A0A194XHE7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_716177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073990.1">
        <property type="nucleotide sequence ID" value="XM_018218254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHE7"/>
    <dbReference type="GeneID" id="28827980"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716177"/>
    <dbReference type="InParanoid" id="A0A194XHE7"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="871" mass="97370" checksum="D648609503CC91C5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIA1</accession>
    <name>A0A194XIA1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative large subunit GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_682777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074305.1">
        <property type="nucleotide sequence ID" value="XM_018214568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIA1"/>
    <dbReference type="FunCoup" id="A0A194XIA1">
        <property type="interactions" value="1234"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIA1"/>
    <dbReference type="GeneID" id="28824294"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682777"/>
    <dbReference type="InParanoid" id="A0A194XIA1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="177"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="653" mass="73111" checksum="386B0E9D70DD8A1D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIB0</accession>
    <name>A0A194XIB0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_705797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074315.1">
        <property type="nucleotide sequence ID" value="XM_018217476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIB0"/>
    <dbReference type="FunCoup" id="A0A194XIB0">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIB0"/>
    <dbReference type="GeneID" id="28827202"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705797"/>
    <dbReference type="InParanoid" id="A0A194XIB0"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="125"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ19960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="49442" checksum="61C4037BF2E03E8E" modified="2016-10-05" version="1">MAGSKKVLMLGAGFVTRPTLDILSDAGIEVSVACRTLESAKKLSADVINAFPISLDVTDEKALDAEIAKNDLVISLIPYTFHATVIKSAIRNKKNVVTTSYVSPAMLELDADAKKAGITVMNEIGLDPGIDHLYAIKTIEEVHKAGGKITSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNAAKYYKDGKIVEVEGKDLMGEAKPYFIYPGYAFVAYPNRDSTPYKERYNIPEAQTIIRGTLRYQGFPEFIRVLVDMGFLSDDAQDYLKEPISWKEATQKILTATSAKEEDLKWAIASKAKFQSTEEKERIIAGLRWVGIFSDEKIIPRGNPLDTLCATLENKMQFEEGERDLVMLQHKFEIENKDGSKETRTSTLVEYGDPKGYSAMAKLVGVPCGVAVKQVLDGTISEKGILAPMSSKINDPIMKELKEKYGIFLVEKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ54</accession>
    <name>A0A194XJ54_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_473498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074548.1">
        <property type="nucleotide sequence ID" value="XM_018207786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ54"/>
    <dbReference type="GeneID" id="28817512"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_473498"/>
    <dbReference type="InParanoid" id="A0A194XJ54"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="180" mass="20137" checksum="B77D5B2F17D3DBAE" modified="2016-10-05" version="1">MHRKVMYNTQTRSTVAGGPDSDDMHCLNSEPDIPVRRIHNPRDLGDQKIIETRVMSQPGKEKEKKPHAGVETPAFIAVALKKRVYNLRQEALKKRSGGDCLAHRAVGCWVSSQPHMQHFGQCLLIRESCSEEKCRCMMQCSSASLSLRWNDTGKIAVQSHENPASWDVTHQSPPATPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ60</accession>
    <name>A0A194XJ60_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UPF0661 TPR repeat-containing protein C16D10.01c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074640.1">
        <property type="nucleotide sequence ID" value="XM_018214428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ60"/>
    <dbReference type="FunCoup" id="A0A194XJ60">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJ60"/>
    <dbReference type="GeneID" id="28824154"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682043"/>
    <dbReference type="InParanoid" id="A0A194XJ60"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="43287" checksum="34B86BC26545A25D" modified="2016-10-05" version="1">MKTKPSRKNDKKARKRGKSALNRVAASPSKSVSPAELLVQAAFVLQQGNIEGSVPLAKRALSLLPSDSEEALPALNLLGEIHVELGDIDAARRYFAQAAAIDEDGKISEDLGGGAEKFLWLAQLSEEGGQDSVDWFEKGALCLRIQIQALLDSKKTDADTEATIAEKTRKLAVALCGVVEVYMTDLSWEDEAEQKCEALITEATMVAPGFAEPWQTLASVRISQQKMEDAKAALTRSLELWKDLPPEDPSVPDFPTRVSLARLLMEADMDVEAIEVLERLVGEDDSSVEVWYLGGWGLYMMGEKQRNGEVKIENGDGESWKVSWISSRQWLQHSQRLFEQQDYQDERLGEHAEELLKTLNAELGGTSADAELEDGDEWEDEGSDEDEEMAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJI8</accession>
    <name>A0A194XJI8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_716405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074282.1">
        <property type="nucleotide sequence ID" value="XM_018218264.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XJI8"/>
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    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="746" mass="80459" checksum="D97EB185BF200B14" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK64</accession>
    <name>A0A194XK64_MOLSC</name>
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        <recommendedName>
            <fullName evidence="10">Alpha-actinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_612340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018210613.1"/>
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    <dbReference type="STRING" id="149040.A0A194XK64"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_612340"/>
    <dbReference type="InParanoid" id="A0A194XK64"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin domain-containing protein"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Actinin_actin-bd_CS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="75922" checksum="5C31871B802FAF51" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLC1</accession>
    <name>A0A194XLC1_MOLSC</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_778571</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075281.1">
        <property type="nucleotide sequence ID" value="XM_018222221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLC1"/>
    <dbReference type="FunCoup" id="A0A194XLC1">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="GeneID" id="28831947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778571"/>
    <dbReference type="InParanoid" id="A0A194XLC1"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29933" checksum="CEFDA1FA1ABCCB05" modified="2016-10-05" version="1">MSSKLPPLITPPLLRYLRQHPQLPKNTWYLIAAVTLTILNRPDEIPTVYRHALEHVTSSNVPGSESQSSSAYDVHAGDFTNSVGKAKLNEELRILRRTREALLKTSAVAGAPKVINACVALKEATPQHLSDVDKFSVTGRSDDISGLSLSLVLRRGQQFFDKIYGKISGRVTRMMKDSGTEDLDQIALLLYGFILSNTTLLDQAETSYVLIAALIPQDLNPQLKGHLKGALNGGASIDEVRAVREVVIRICESAGMKKLDGMVGFGWQGDIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLE4</accession>
    <name>A0A194XLE4_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_681583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075306.1">
        <property type="nucleotide sequence ID" value="XM_018214327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLE4"/>
    <dbReference type="GeneID" id="28824053"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681583"/>
    <dbReference type="InParanoid" id="A0A194XLE4"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="105" mass="11092" checksum="ED63446F8694ABBA" modified="2016-10-05" version="1">MAKDLVAILVNELHPRYKLVHLANTNAIYGLGALLESLVVVPHILICSSQWTLDQQSLIQGIANEMCPGIKTVAVPPGLSAVKGTTAAVGFVREEILSMGLSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLE5</accession>
    <name>A0A194XLE5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 13">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_695206</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 13"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074952.1">
        <property type="nucleotide sequence ID" value="XM_018216755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLE5"/>
    <dbReference type="STRING" id="149040.A0A194XLE5"/>
    <dbReference type="GeneID" id="28826481"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695206"/>
    <dbReference type="InParanoid" id="A0A194XLE5"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23425">
        <property type="entry name" value="beta-trefoil_Ricin_AglA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000177">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF91">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268379" description="Alpha-galactosidase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="414"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="537" mass="59163" checksum="6066F93ED9B4194A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMA0</accession>
    <name>A0A194XMA0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_418273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075252.1">
        <property type="nucleotide sequence ID" value="XM_018207385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMA0"/>
    <dbReference type="STRING" id="149040.A0A194XMA0"/>
    <dbReference type="GeneID" id="28817111"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_418273"/>
    <dbReference type="InParanoid" id="A0A194XMA0"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="340" mass="36450" checksum="25520DD116E90FEC" modified="2016-10-05" version="1">MAFQSLTYLAGDSDGRIHVKHSKRAIGGLEVLVRVSHSGVCGTDVHDRTSGCGLGHEGVGIVEKIGDCVTAVNVGTRVGWGWQFASCGHCRECVSGYRQYCPKSCGQKYGELEQGAFGDYVIKHQDFVYPIPEKIQSKYAGPLQCAGITVYEALDVAGAKPSDRIGIVGLGGLGHLAVQYARAWGCDPVVFSMNSAKKEDAYKLGAKEFHIMPSSIEGTLNVSEGVNVLLLCGGALPDLRLIMPTLARRATIVPLIIQGQPLVIPYMPFMLPGHRIIASTEASRSNHIAALTFAARHGIRPWIEEFPMSAAGLTKALDALKGGKIRYRAVLSIDTCSDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMI1</accession>
    <name>A0A194XMI1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_715568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075723.1">
        <property type="nucleotide sequence ID" value="XM_018218218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMI1"/>
    <dbReference type="STRING" id="149040.A0A194XMI1"/>
    <dbReference type="GeneID" id="28827944"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715568"/>
    <dbReference type="InParanoid" id="A0A194XMI1"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="4">
        <location>
            <begin position="471"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134442" checksum="01BB692F048CFCAD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN37</accession>
    <name>A0A194XN37_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_777990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075928.1">
        <property type="nucleotide sequence ID" value="XM_018222176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN37"/>
    <dbReference type="GeneID" id="28831902"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777990"/>
    <dbReference type="InParanoid" id="A0A194XN37"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35259" checksum="CD1D2E983980315F" modified="2016-10-05" version="1">MTEPTRVYQWVCHGLKKGEECGKVNPICKVKCYRCGSDRATCGTDYVDDAGSEPNETWDCCNCRHGNAEDETECDHCTHDRCSTCKLRGPRGPDVHLWICDNEKRKNILCGEFNTVEYTECKKCGGPAVNSHPWTTHRYTRSSRVDTWQCSNCAGRNIEEDKVCGYCPHFRCDECYEPDRSITGSYCGSDLGSDAGTDLGSVAYSDAAENCPKESIEDGSALFGRECSQLKKGFPCQQRNWEPAENCDRCGNSRQGRDIFLVDRCPEHTFVWVCCVCDGGNNGEALDEECEYCPNHRCDACLPGLRGNSICLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNB2</accession>
    <name>A0A194XNB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_694180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075986.1">
        <property type="nucleotide sequence ID" value="XM_018216684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNB2"/>
    <dbReference type="GeneID" id="28826410"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694180"/>
    <dbReference type="InParanoid" id="A0A194XNB2"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="24701" checksum="B878A36F79AD28BA" modified="2016-10-05" version="1">MAPQTGRLAAFTRPCGLIWFSITPSGFIAFEDTTIVPSLVEAATGVVLELGPGPGNQIHRFNYSVVKQVYGIEPNANFKADIDAKLEKHGRQDKYKLVVAGIEDSDVLRREGITEGSLDTILCIQVLCAVKDPKTVMKEVWKLLKPGGKFIFWEHGWSRNHLTIVEQAVLDPAWSTFIGCHMTRNVLGDILNGGEWENPDEIEEPEDAFSCLPRIQGVLVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNH4</accession>
    <name>A0A194XNH4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_380729</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076056.1">
        <property type="nucleotide sequence ID" value="XM_018207130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNH4"/>
    <dbReference type="STRING" id="149040.A0A194XNH4"/>
    <dbReference type="GeneID" id="28816856"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_380729"/>
    <dbReference type="InParanoid" id="A0A194XNH4"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="188"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ21701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="50283" checksum="AB9D41696AED9EBB" modified="2016-10-05" version="1">MLPRLQFRCRALLSFLLVCLCIYLFDPYDNPAILFLRWHGGKVRYHTKSVFLPSGYPQHTRDVLCNITSDDIGLIIKTGYATKSRLESKLRVIDGRWKNENVAIASDYGSYGEMRMNDQAVQVHDVLAGLIEEVEDQSPVRVRLYKKFKKAIKYQSSMPQEDILKSGWELDIMKHIPALELGLEQLPDKKWYLMIDDDTYIHIPSIISILSTLSPSKLHYLGKALGSYTLRFAHGGSGVVFSHAALAHIFQPKHVPLLDQLKLKSLTSEVELGDKLIGELAMGTGIYLNEEYSTHFNGESPWRSKVTKESVCSEVVGFHGLEVEQMGKVKEGLSAVQSVVRWCDLGGLFGGGEFEIENNKTRDGALTAVRQGWDFVGQVGEQPIILEGGDAKDCEKTCAEREECLSWKSEAQKCWAVPWATGGEKTGDKIVSGLRYERLNHLIQSCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPL3</accession>
    <name>A0A194XPL3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_576902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076369.1">
        <property type="nucleotide sequence ID" value="XM_018208862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPL3"/>
    <dbReference type="STRING" id="149040.A0A194XPL3"/>
    <dbReference type="GeneID" id="28818588"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576902"/>
    <dbReference type="InParanoid" id="A0A194XPL3"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="296"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="407" mass="46255" checksum="A644F5EBC1D28EB5" modified="2016-10-05" version="1">MQESSQPRAIPERSILQIPPTSSITLPPPPSSAGRIRSSHLNLDTFSPVNQNGSFEFDRVLKSGYVQKRTRKTKAWKPVFLVLRPNSLSIYKDQNEDKLRHKIHLSDLTAVAFLKDPKQKRQNVFGLFSPSRNYHLEARSRKDAEEWVGLIRQEARIEEEEEEMLLASPSGNLTNPYNGFDRAMQKHHEQKLLHDERLGSSSPEPTDPIPRTQRTEALGLHAPRRPSHTIEYSGNEVSDMSDADLTRARNHSSVSMPEEPLAVQAPGSRPILDARNTSQVSVTSPATEQDPNSSERVVWQGYLLYLKTIRGVRQWKDLWVVVRPKSIHMYKNDSEYSPILIIPLSSVINAVEIDPLSRSKTHCLQVITEEKSYKFCAHNEDTLDTSLGALKSLLAKRKEHEGKIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPU0</accession>
    <name>A0A194XPU0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_576614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076117.1">
        <property type="nucleotide sequence ID" value="XM_018208846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPU0"/>
    <dbReference type="FunCoup" id="A0A194XPU0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XPU0"/>
    <dbReference type="GeneID" id="28818572"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576614"/>
    <dbReference type="InParanoid" id="A0A194XPU0"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="470" mass="51298" checksum="E635CE268C937225" modified="2016-10-05" version="1">MPLTVLTDANVKDILQSLDREELLDLQSSMREALHEYATGTTSSGASAANQPNRTVIESSNGTTTLFMPSTSSSGIGMKVVTLAAPPASPEKDAEIDSEATTPQGALTLMDASGRPFGFLNAEEVTAFRTALASSLLINRRTKVKTLTVFGTGKQAYWHVRLALLLRGPTIKKVHFLNRDFNHRAAMCMKSFVGYDPAKKRAEGWFDTTFDLTSLKYGEIGRILKDHVRAADVIICTTPSSEPLFDHTILTNTEGRRRARLIIAIGSYKPHMIEVPPEVLTQAIKVHGPGFHFHKHAEEGGVIVVDTLACIKEAGELVQASVPPDRTVELGELVMLEQMHMPQEDDSAIDDSPEDSTNENVSPVSPDSSRSLARAFREHSIDGGPKSASVSRKSSFSRKGSFSLHSRSGSMSSLRRKKIQTEKEDQMSRWLSGGNVIYKSVGMGLMDLVVGSDVIKLAREKNIGVTVDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPY2</accession>
    <name>A0A194XPY2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076469.1">
        <property type="nucleotide sequence ID" value="XM_018219392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPY2"/>
    <dbReference type="GeneID" id="28829118"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729585"/>
    <dbReference type="InParanoid" id="A0A194XPY2"/>
    <dbReference type="OrthoDB" id="10448543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="47124" checksum="6885D64F248617EB" modified="2016-10-05" version="1">MEQDGDTPAMPLSTTVVSWQTALWTLLPLALNLWGQPSGRVLSLPSKHGSMLRSFPPLALMDSISLLVSLVYTCFFLHVGPCQSLALVFQERFSSPDQTMHYRQLLREGQRLRWLMFVCGVVQSSIKLNSMTGIFWTKACGASWVFSWLLIEILSFLAPGPTSDSPAEGTPSSSTATDDEWPSYSGNRYQLQLWQAYSKRIHSEYLGIAISIQFWISISMLVHLIVPDMGFPNSLTTAMLRWIIIGYCPLVAVPRWYPKVTMKLGQVLSVGSFIDWWSGTSTVLLFCGLVQWILDHFEVFHNYTRPWQPLFVQYTFCFMSMIVITVMRSILRKVVRWLRSRRLGRYGWPTDINARQRVLDDIRTSTDESDGETLWLAWLLATNFAVWVLWYAYRYNSEGTNNPGWTMVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQB7</accession>
    <name>A0A194XQB7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">LY89DRAFT_636289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076711.1">
        <property type="nucleotide sequence ID" value="XM_018211484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQB7"/>
    <dbReference type="FunCoup" id="A0A194XQB7">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQB7"/>
    <dbReference type="GeneID" id="28821210"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636289"/>
    <dbReference type="InParanoid" id="A0A194XQB7"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="449" mass="49309" checksum="665C615776AE034E" modified="2016-10-05" version="1">MDHGLKAIKYESGKLLVLDQLKLPHEFVYDNVSTCEEAFDCIKSMRVRGAPAIAIVAALALAVELWHKKDDASTKQNLVEYINRKLDYLMESRPTAVDLSNAIRLLKTQTQKAAADTTTSDEIQACDSIRTRFVQVAKKIFDDDLATNQRIGMWGAEYLRALQPPVTDAVAASNDFRYYTTSPPGTQGASDQTYRKISVLTHCNTGSLATSGVGTALGIIRKLHDMNYLDHAYCTETRPYNQGSRLTAFELVYEKIPSTLITDSMAASLFKTYKDEKNITAVIVGADRVVRNGDTANKIGTYQLAVLAKAHGIKFVVAAPTTSIDLEKENGDLIKIENRAQTELTQISGAVVGKDGKVDVNNTARVAIADQRINVWNPAFDVTPYQLIDAIITEHGPVPRNAKGKFDFKAIMPERWKVQVEDGEAVVNVAGTAVKMNGSDGLQFQMEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQV4</accession>
    <name>A0A194XQV4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_394314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076462.1">
        <property type="nucleotide sequence ID" value="XM_018207215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQV4"/>
    <dbReference type="GeneID" id="28816941"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_394314"/>
    <dbReference type="InParanoid" id="A0A194XQV4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24081" checksum="6CE234C3667B3D6E" modified="2016-10-05" version="1">MRLRRGVRQTEDSSPRLVTVSLQTAVEDRRRREKRSQWHRRCSSVVVDEGQLKESCCDGRWSCAGWMELDWIGEDRGVEAELAASVKWSLAALGWAGLVWSTAGWVYFCVRCGTMQCRQYNLLVGGEKNVGCYEYDDEKWEMCFVILSGLEFLHTHILRYGSCRQRAINDEAVSVYGSPNSLPWLPPLLLDCDRLKPRAGERQNGLKMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQY9</accession>
    <name>A0A194XQY9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_665278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076502.1">
        <property type="nucleotide sequence ID" value="XM_018212831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQY9"/>
    <dbReference type="GeneID" id="28822557"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665278"/>
    <dbReference type="InParanoid" id="A0A194XQY9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="109" mass="12587" checksum="A66ACDE55E337EAC" modified="2016-10-05" version="1">MNSTSSSSHGAEATNRQELVRKRGYDAEITVHIGGIQRDEMKQIGLYWPLRKQMSHNVDIFNRHDYRIEEDLSKAVPTKRKANAGNHSICAQYLTEKYIEVFIDLQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRM4</accession>
    <name>A0A194XRM4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_607637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077156.1">
        <property type="nucleotide sequence ID" value="XM_018210468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRM4"/>
    <dbReference type="FunCoup" id="A0A194XRM4">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRM4"/>
    <dbReference type="GeneID" id="28820194"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_607637"/>
    <dbReference type="InParanoid" id="A0A194XRM4"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF10">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ22801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="39488" checksum="C4BE213E8E7C5A8B" modified="2016-10-05" version="1">MSPQKCPIILLDGGLGTLLTSPPHLQTFNHSTPLWSSHLLLSSPSTLLSAQSSFATSGADVLLTATYQVSFEGFANTAPGYAAKDAERYMRSAVGIARQALSEGRGKGMGKLALSLGAYGATMVPSSEYSGVYDSSHSSITQLRDWHFKRLEVFLPLKEEEEERRECWRNVDLLAFETVPRIDEVFAVREAVFMSMGRAEERPFWISCVFPGEENRLPDGSSLREVVRAMLGRREGASRPMGVGLNCTKVGKVDGLVREFEDALKDLGEDGRGVSLVIYPDGTRVGERYNTVTQRWEVDEEARKGGQEKEWDEEVFGIVIRARERGVWESIYVGGCCRVGPEEIGKLRKRVDKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSE8</accession>
    <name>A0A194XSE8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_776793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077319.1">
        <property type="nucleotide sequence ID" value="XM_018222079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSE8"/>
    <dbReference type="GeneID" id="28831805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776793"/>
    <dbReference type="InParanoid" id="A0A194XSE8"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268602" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="103"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="402" mass="42996" checksum="AE6B18171C788B2B" modified="2016-10-05" version="1">MYSLYFTAALAILPTIILAAPHNISCPATPSPLPKEASFDVVSTLPDPFLYLDGKTRVKTKEEWFACRQPEIMHFLEEYQYGYYPDHSLETVTATRSGKTVNVVVAVGSTKATIAATVNLPTGASASSPVPVVISIGGMDNAAYLAKGIAVVTFDYSAVASDSNSKTGSFWTVYKGRDVGTLLAWAWGFHRVLDGLIIAAPEIDSKRVGVTGCSRLGKAALAAGLFDQRITVTMPMSSGVQGLGPYRYHALSGQDETLENSKSGAPWWSDSTLGTFVNNSERLPYDAHTIAAAIAPRALIIDQGRSDPYTNSKGTAIVVYPAVKLVYDFVGLNGTTLGAGQPKSQIGMALRDGGHCDNSGYSNVLPFVQEVFFGTATTRNYDDLTPWTAMTTAYPWSTSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT08</accession>
    <name>A0A194XT08_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zf-ZPR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_679978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077534.1">
        <property type="nucleotide sequence ID" value="XM_018213983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT08"/>
    <dbReference type="FunCoup" id="A0A194XT08">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XT08"/>
    <dbReference type="GeneID" id="28823709"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679978"/>
    <dbReference type="InParanoid" id="A0A194XT08"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="63"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="284"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="56785" checksum="BF7B44E3145E3348" modified="2016-10-05" version="1">MASNTHEEPKPDGAAFDDFFESLGKKAEHLSVEDKNGVPPTNDQFESTEDDDGEPKIVDEIESLCMNCHENGITKLLLTRIPFFREIILMSFYCPHCNFKNSEIQSAGEIQQKGSHYELRLTTKEDFARQVVKSDTCVVKFIELDIEVPAGRGQLTNVEGLLSMILEDLELQQPERKEQIPEVWAKIEEIVQKGRNMIKGESFPFRVSLDDPAGNSWIEPDQKDGVGKWSKVEYARTPEQNEALGLGSGEEEEQKPEPAVPGQPTAASFETDDIIPNEVYSFPATCPGCTKYCVTHMKMVDIPHFKQVIIMSTVCDQCGYRSNEVKTGGEVPEKGKKITLKVEGPIDLARDILKSESCALECPELSLSVNPGTLGGRFTTVEGLLTQVRDDLHQQIFDIDDSNDAGGDSLPSESKQTWKAFFDGLDHAIKGERKFTVILKDPLASSYVQNLCSPNEDPQIETEEYERTEEEKEDLGLADMKTEGYVDEAGEKKKEDAADEAQRIEESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU04</accession>
    <name>A0A194XU04_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_663651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077542.1">
        <property type="nucleotide sequence ID" value="XM_018212719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU04"/>
    <dbReference type="GeneID" id="28822445"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663651"/>
    <dbReference type="InParanoid" id="A0A194XU04"/>
    <dbReference type="OrthoDB" id="10591223at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="370" mass="41638" checksum="9E5E9E2C75E37812" modified="2016-10-05" version="1">MDAGLLRHYAAPYAYNYRGNLYRQWWRFLNSKDQEGNPVLSDLDIRRVASKYTTNWNPTGKIRIRSADRQAFVDNAIAAAPDDILAHKKDRRVALPDGSNCKYGCVFCWRRFPRKDNRDAHERSAYQEGLNPEAICNLLQETHGLTASPWTLESRIETWRLRQKVDLGPYFSEIKGAYEQGVIPSEIRKPIYNKCKAMISAKVLNEHMQQWGLHVRAPQAKPERIESRTGEVEIVQATAMRKEVVKLGVEEPDISLLKTLVDTGSSDLRKRKFEGQAVNAVAQIGEISAITSAGEKKAWSGGILSCTDPDDIEQDNDGAWAGWTGFPPRLQQLTPLLNGLRHGLISSAIKNGAGVYLKRRNEQNSSGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU38</accession>
    <name>A0A194XU38_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_662531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078078.1">
        <property type="nucleotide sequence ID" value="XM_018212651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU38"/>
    <dbReference type="GeneID" id="28822377"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662531"/>
    <dbReference type="InParanoid" id="A0A194XU38"/>
    <dbReference type="OrthoDB" id="10680419at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="25986" checksum="A33CEBC86690CC9E" modified="2016-10-05" version="1">MSKYGQMISEERSDHLNQQLARQGVEEYVLRRGNWPRQLLESVSRPTRSSPYTGIPSNHEHCIVQDEVCTQNLDLIKGIWNDSNKDDFDMRELQERNEESGFGYTSYNADTFPSFVHNENNHDIIANERWRTPADLPRIAARELVDGMIDIFLPLEENGVKVNDPEELARRRDYFLPRDGENGRLESQVLIEHLSGVRAATKMPSEPAQTLVMDGFGVLHWRFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUM6</accession>
    <name>A0A194XUM6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_726801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078094.1">
        <property type="nucleotide sequence ID" value="XM_018219083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUM6"/>
    <dbReference type="GeneID" id="28828809"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726801"/>
    <dbReference type="InParanoid" id="A0A194XUM6"/>
    <dbReference type="OrthoDB" id="3563271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="14662" checksum="6282C3A973530675" modified="2016-10-05" version="1">MSTSGSRHLKPIIHSRNSSTDSRTSSQSSSSGEYRYYETSTSRSTMANGGYREDREKRTEKRRVPDNKSHVMTTMTSRSGKNKVHAHGARYYDPEEPRASEARYEDYQRTKDYNRSSQPSYSSGSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV41</accession>
    <name>A0A194XV41_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_727056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078361.1">
        <property type="nucleotide sequence ID" value="XM_018219116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV41"/>
    <dbReference type="STRING" id="149040.A0A194XV41"/>
    <dbReference type="GeneID" id="28828842"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727056"/>
    <dbReference type="InParanoid" id="A0A194XV41"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ24006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="567" mass="60880" checksum="ABE3898602C36FC7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVV9</accession>
    <name>A0A194XVV9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_557297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078504.1">
        <property type="nucleotide sequence ID" value="XM_018208394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVV9"/>
    <dbReference type="STRING" id="149040.A0A194XVV9"/>
    <dbReference type="GeneID" id="28818120"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_557297"/>
    <dbReference type="InParanoid" id="A0A194XVV9"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="22487" checksum="0BE60C9DB898DA2D" modified="2016-10-05" version="1" fragment="single">MEQMKALNALEPFLALTKSASSPRAAADLITRATSAPNTFIFAELLQAPQIQALAESEDHSSHLTLLKIFSYGTYTEYRSTPSLPSLNEAQTLKLRQLSLLTLAKNQADLTYKSLLGHLGLETTRELEDLVISAIYAGLLNATLDPYHELVAISSVAPLRDLQPNSIPQMLVTLNEWSSRCVSTLADLERQIASIKAEAKRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWA9</accession>
    <name>A0A194XWA9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_703545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078878.1">
        <property type="nucleotide sequence ID" value="XM_018217328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWA9"/>
    <dbReference type="GeneID" id="28827054"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703545"/>
    <dbReference type="InParanoid" id="A0A194XWA9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="60773" checksum="89B43E8E1570E070" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWV6</accession>
    <name>A0A194XWV6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_556607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078884.1">
        <property type="nucleotide sequence ID" value="XM_018208378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWV6"/>
    <dbReference type="GeneID" id="28818104"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_556607"/>
    <dbReference type="InParanoid" id="A0A194XWV6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="52" mass="5988" checksum="1812F4999741F155" modified="2016-10-05" version="1" fragment="single">YAKLIYRALMSAPNHSMVLQEIYQWFRDNTAKGASDGKGWMNSIRHNLSMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWY2</accession>
    <name>A0A194XWY2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_693246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079026.1">
        <property type="nucleotide sequence ID" value="XM_018216620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWY2"/>
    <dbReference type="FunCoup" id="A0A194XWY2">
        <property type="interactions" value="897"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWY2"/>
    <dbReference type="GeneID" id="28826346"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693246"/>
    <dbReference type="InParanoid" id="A0A194XWY2"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="14">
        <location>
            <begin position="107"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="13">
        <location>
            <begin position="298"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ24671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="614" mass="68049" checksum="EF177A90F5571CD8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1T0</accession>
    <name>A0A132B1T0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_678911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060606.1">
        <property type="nucleotide sequence ID" value="XM_018213779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1T0"/>
    <dbReference type="FunCoup" id="A0A132B1T0">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B1T0"/>
    <dbReference type="GeneID" id="28823505"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678911"/>
    <dbReference type="InParanoid" id="A0A132B1T0"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="217"/>
            <end position="358"/>
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            <begin position="852"/>
            <end position="1011"/>
        </location>
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            <begin position="382"/>
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        </location>
    </feature>
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            <end position="586"/>
        </location>
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    </feature>
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            <end position="425"/>
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            <end position="509"/>
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    </feature>
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        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KUJ06251.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1093" mass="119952" checksum="2F46CBFEF1736E5D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1X8</accession>
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        </submittedName>
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            <taxon>Leotiomycetes</taxon>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06386.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Q0</accession>
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        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
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        </subcellularLocation>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
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    </dbReference>
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        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="49456" checksum="D1E14263544F0DE5" modified="2016-05-11" version="1">MADYKTYLASSILTEDKIVSYRLLSRALKVNVNAAKEMLYEFHRQQNGKKPGTIHATYLISGTKQKEPEVANDAVEQDGEDTHMQSSPPFMSSSMPQPQETSDDSGVLSITLVREENLDEVRSQYEHITSIHVYSIGPHPLKDLQILSDITRQVREICADEDPLETASTYGTIINKNAKRREGKRPPPAPAPVAPVPAKAQPAKPKPAESKPEPPPKKEISSTAKDFFGKSNSKPKANPASNPSSKETTPNPPTLKRDSSSIFKSFAKAKPKLKREGTDSSVADSPALSPAEDSPMKGLSDDDEEETYVSPAPADMEIVNKSRKERKENEEKLRQMMEMDDEDEEEEIKEIEEPEAVEKEASVEKEVPPTVSGGRRRGRRRVMKKKTVKDEEGYLVTKEEPVWESFSEDEPAPMQKPKAHAPVASTKGKKAAGKAGQGSIMSFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6R7</accession>
    <name>A0A132B6R7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_725703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061929.1">
        <property type="nucleotide sequence ID" value="XM_018218996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6R7"/>
    <dbReference type="GeneID" id="28828722"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725703"/>
    <dbReference type="InParanoid" id="A0A132B6R7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="61150" checksum="5C008B34B057BCF0" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6V1</accession>
    <name>A0A132B6V1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062493.1">
        <property type="nucleotide sequence ID" value="XM_018220822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6V1"/>
    <dbReference type="GeneID" id="28830548"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742430"/>
    <dbReference type="InParanoid" id="A0A132B6V1"/>
    <dbReference type="OrthoDB" id="5428966at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="20360" checksum="1A9FDE052FA49D45" modified="2016-05-11" version="1">MEIHKVHIKDLYLGQNKTVDEVRYDMEMNHSFTASKTEIERQLRKWNFKKNSRHSLNTQLLKYVKVGLEEWKRLSKDTDVYFRGVKIPSPQIQKSAQRCFVSFTERNKCEYMPNTTSKPVLIIGQVPTLETPSGLVLITPSSEHYMACIKSKDLPWIYFQKQIDSLASSICLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7I0</accession>
    <name>A0A132B7I0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_789497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062189.1">
        <property type="nucleotide sequence ID" value="XM_018223262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7I0"/>
    <dbReference type="FunCoup" id="A0A132B7I0">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="GeneID" id="28832988"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789497"/>
    <dbReference type="InParanoid" id="A0A132B7I0"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="643" mass="71839" checksum="35A6CAB39BD37CD2" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8A5</accession>
    <name>A0A132B8A5_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">DNA repair family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_629612</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08483.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B8A5"/>
    <dbReference type="GeneID" id="28820938"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_629612"/>
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    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="47"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
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            <position position="202"/>
        </location>
        <ligand>
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        </ligand>
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            <position position="212"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
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        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
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        <location>
            <position position="299"/>
        </location>
        <ligand>
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        </location>
        <ligand>
            <name>2-oxoglutarate</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="37967" checksum="C3F53CC943F1DC3C" modified="2016-05-11" version="1">MSSSTKKRTLDAFFKPPAKKAKSSDVVDSGDLEQADETSSAPDQDVEFSKHTTYPFPIVNFPTSISSALPSFPSTIGKEINDQADLDLLYFQPYVPKYLESQISQFLRAELPFYRVEYTIKRGGVETQIRTPRYTTVFGLDETSRFDENGEVVDAKTRKKISNDKYYSKYSPRPIPKCLDDLRLSTEAATGCKFNFCLVNYYASGSDSISYHSDDERFLGSLPAIASFSLGARRDFLMKHKPIIPNDSAPPPPATTPIKLPLASGDMILMRGPTQANWLHSIPKRTGKNAEDGGRINITFRRAMVKGGTENYYNYNVGNGPVFRWDERSREMKLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B997</accession>
    <name>A0A132B997_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">Kynurenine 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_763453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B997"/>
    <dbReference type="GeneID" id="28831325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_763453"/>
    <dbReference type="InParanoid" id="A0A132B997"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="407" mass="46110" checksum="F57B1447983A5D77" modified="2016-05-11" version="1">MSFQKDQKVAIIGAGLAGMSLALALHKQSIPCTIYELRDSASHLTATGALMLCPNALKVLSEIGVYERIKNQGYMFEKLEYKDENYKITDEYYLGGEKLFGYKALRVYRDILLRETLGAITERGIQVQYGRKFSKVVKEDETGVEFAFEDGSTESATLLIGADGIHSKVRQYIHPNVGPIFSGMMAITSVVHVSDLRFPEPNYHLTTSIHSKYGAFVFAPQNSSGTEILVGTQMRMPEQDQEGWRRIRQNKDELKSMFQAHMNEWPDLVQSAMEHMNPDKLSIWPYYVVPKLDTWSSPGKRVIILGDAAHAIPPTAGQGASQAFEDVYSLSLLLSKLSDKVKLDDALDFWQCYRMARVDDVLALTRKLDVKRLPTEDKAKVPEEVVWLFEPKIEEKMLKWVAEQENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9E8</accession>
    <name>A0A132B9E8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_630150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062652.1">
        <property type="nucleotide sequence ID" value="XM_018211231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9E8"/>
    <dbReference type="GeneID" id="28820957"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630150"/>
    <dbReference type="InParanoid" id="A0A132B9E8"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="entry name" value="GAL4"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="48"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54850" checksum="A59EF2456DC4F43D" modified="2016-05-11" version="1">MEGLEGENSGEADLKCDLCSKSYQRRDLLLRHRRRCQGPKKAVTRRKACDACVQAKVKCSYAQPACSRCSLRGTRCIYTVRSEASTSMHQDSEDATAGPSNLQSSSSEIESFASSSVGTEMGIPAWDFSTPLYSLNNFEMDMPDIGNPFADSQSSMLRGTSEFPPSSQAMLSSSSNVTAPLRLVPPSHDSTLSAENSPSVSDSRALVQKLDEYPSLLMKSSFFSPFLHMSLYSLYSNIVPDMTYLPQTSMAICCGSETHNSDNNQFIKRAIDAARQRLIGSFPSYECMQQWDALHAMLIYEILELRESLREEPETWKHDPRVQGLRSPFLLKMTQTYLRSYPEIQNPDIDAFSNPSSAPCSAATTVWARWRITETARRTIFFTNILNFYSNRDHTTGRQMPYYESLNDDLILHMPLPCSQASWSARNEEDWRVAIEQEFRTEIFLRDVLARYTKEQIQVKFGTSVGFGSSDELRGLIVLCAREQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9W4</accession>
    <name>A0A132B9W4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_598700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28819780"/>
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    <dbReference type="InParanoid" id="A0A132B9W4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1376"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
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        </location>
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        <location>
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        <location>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="685"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1098"/>
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        </location>
    </feature>
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        <location>
            <begin position="1132"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1422" mass="155356" checksum="F7FA37480C94FD02" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA53</accession>
    <name>A0A132BA53_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_281924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA53"/>
    <dbReference type="GeneID" id="28816188"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_281924"/>
    <dbReference type="InParanoid" id="A0A132BA53"/>
    <dbReference type="OrthoDB" id="3526531at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="33693" checksum="0EDE587A15D4A5BB" modified="2016-05-11" version="1">MDHFRDHAPKEVRALEVWDKSLNLAEESRRRLWVNTAQGAEVCSVREMASRTRPSTPRTEGDAPYGVLPAAKESSVATPLAVHLYCGFEGRFADTILGEVLSVFARPRLESLHFSSEPNNLKRRPLTRLELYKAQFSSNPWRHLLPSVSPANETLKRVSLDCSLFWSEFAYVLPHLHALERLNCGLTCLRFEPEPCPVPIEWETREQAHKHILDACLNNRVEKTQDKKWIQITKDGIVLPNIEPHEQRVLNEADSMFYQFPWEEKVSIQFHEGLLQRSRERSLINTLSCNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAJ8</accession>
    <name>A0A132BAJ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_724412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063771.1">
        <property type="nucleotide sequence ID" value="XM_018218895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAJ8"/>
    <dbReference type="GeneID" id="28828621"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724412"/>
    <dbReference type="InParanoid" id="A0A132BAJ8"/>
    <dbReference type="OrthoDB" id="3557569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="37113" checksum="327B37CC9074380D" modified="2016-05-11" version="1">MVDLSLEQVEHVSQGRSKSENADSKQVETRFTLFPELPKEIRLEIWASAMPGPRLVFIKQQRLVSHVKNQKREPDSGLPPYGHGDVEQESTSTRAWRTFRSGLGSEDSVSEDEDAEMIGIACKTPVPYVFLACKESYSVAAKLYKRTFARTNSNPETYFNFEQVTLCLDGDDFSMNVIRFFGPFNMLRTIRVGFWQGFRQEDDEDVGKVERLGIRVAPNQPFFHESAVADVLKIFHGVKELFFILEMRNDHEHMAASDSYLLDPPESDILAEAEFHGIDPNEFYITDQKLNMTMLRALEERHGCWTLPYIAGKILGSGATGIQKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAM3</accession>
    <name>A0A132BAM3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_701454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063820.1">
        <property type="nucleotide sequence ID" value="XM_018217196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAM3"/>
    <dbReference type="GeneID" id="28826922"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701454"/>
    <dbReference type="InParanoid" id="A0A132BAM3"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="48766" checksum="890F8F96DFB08F6A" modified="2016-05-11" version="1">MSTSQLIELAGIITRETEKLDRFLKQSGSAQPSFDVDGPTNFPKMSDEMKSARDEVVRATRELGDLVAGPTENIRWMAWDHNNSLSLHAIYHYKIAQSFPIHETATFAQIAEKVDLDEINVRRFLRHAMTNRIFKEVEPGVVAHTAASRVLAEDQMINDWVGFCVEDIWPAASRVVDAINLNPSASEPSQAGFCVANNTIDVEPMFVTFGKSPKRAKRMGGAMTSLTGGEGYEVSYLVNNYDWSRINASSGTVVDIGGSHGFVCIDLAEKYKKMKFIVQDLPKTVQSAPKLEGDLGERIKFQVHDFHTQQPVKGADVYLYRWILHNQSDRYSINMLRQLIPALKKGARVVINDHCLPEPGTESLWDEKIIRSMDLVMLTLLNARERSEGEFEDLFKAASEGLSGGFRFLGAKRPEGCRMSIIEAVWEGEDFGGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAY6</accession>
    <name>A0A132BAY6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_787845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063893.1">
        <property type="nucleotide sequence ID" value="XM_018223111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAY6"/>
    <dbReference type="STRING" id="149040.A0A132BAY6"/>
    <dbReference type="GeneID" id="28832837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787845"/>
    <dbReference type="InParanoid" id="A0A132BAY6"/>
    <dbReference type="OrthoDB" id="3837332at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="878" mass="97650" checksum="778CBA9FE1AF9C12" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAZ2</accession>
    <name>A0A132BAZ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_321005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063524.1">
        <property type="nucleotide sequence ID" value="XM_018206717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAZ2"/>
    <dbReference type="GeneID" id="28816443"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_321005"/>
    <dbReference type="InParanoid" id="A0A132BAZ2"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="612" mass="66701" checksum="BE7804ECAB6FEAE7" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCW9</accession>
    <name>A0A132BCW9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_628140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064194.1">
        <property type="nucleotide sequence ID" value="XM_018211173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCW9"/>
    <dbReference type="FunCoup" id="A0A132BCW9">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="GeneID" id="28820899"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628140"/>
    <dbReference type="InParanoid" id="A0A132BCW9"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="27497" checksum="81E29FC2597FCFBE" modified="2016-05-11" version="1">MSETKSIILTGASRGIGLAIARYLLTQKHNVFLVARTKAPMEELKKEFPGQVDFLAADLADFEVGPKVISQAIKSFSRIDGLIINHGTLSPVKRVADTTAAEWQSAYNINLFSAIAFIQPAMPYLRQSHGRIILTSSGAALNSYSTWGAYGSSKAAFNHLAATLKNEEPDITTIAIRPGTVDTEMQAEIRKNKDVMDAKDAEKFGSLHTEGKLLKPEQPGNVMARLALNADKELSGKFVNWNEKELEAYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCY5</accession>
    <name>A0A132BCY5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_740021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064645.1">
        <property type="nucleotide sequence ID" value="XM_018220539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCY5"/>
    <dbReference type="FunCoup" id="A0A132BCY5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="28830265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740021"/>
    <dbReference type="InParanoid" id="A0A132BCY5"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001164">
        <property type="entry name" value="C2H2 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1073" mass="119450" checksum="A29E60469B998332" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD06</accession>
    <name>A0A132BD06_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_723916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064488.1">
        <property type="nucleotide sequence ID" value="XM_018218855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD06"/>
    <dbReference type="STRING" id="149040.A0A132BD06"/>
    <dbReference type="GeneID" id="28828581"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723916"/>
    <dbReference type="InParanoid" id="A0A132BD06"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="303" mass="31823" checksum="28AD4716ECF314D0" modified="2016-05-11" version="1">METVNNIASAASRAIWGESAQTGETATAAGTEPVSGKTGNVEAGEPYDKGNDGEPVNNTSSSTTTDSKLPTYLNYQKENANTDTTTSKDTTTNSSTDTPSTAPTTTPSNTTTSKMTDNTPSTSIEKPTTSSTDDSSTTAPPSNRSDPAPAAQSAANQEAIQKSTPADTTPADKNDDKEDDEATQQAGLKADGITETSKEGDHAPKFDTFKTSDGPHIGDGKNDGRVGPPIEKGDLKEFENHDGSETKKEEGEGKVEGKVAEEKHAHHGEESVKKDTESAERADSPGKEKVSLKDKIKAKLHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRY4</accession>
    <name>A0A194WRY4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_700656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065090.1">
        <property type="nucleotide sequence ID" value="XM_018217138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRY4"/>
    <dbReference type="GeneID" id="28826864"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700656"/>
    <dbReference type="InParanoid" id="A0A194WRY4"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF15">
        <property type="entry name" value="DUF885 FAMILY LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="64119" checksum="930F9CB690CEE85A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT39</accession>
    <name>A0A194WT39_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_700408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065481.1">
        <property type="nucleotide sequence ID" value="XM_018217119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT39"/>
    <dbReference type="STRING" id="149040.A0A194WT39"/>
    <dbReference type="GeneID" id="28826845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700408"/>
    <dbReference type="InParanoid" id="A0A194WT39"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="341" mass="37496" checksum="1BADE9A22D384C7D" modified="2016-10-05" version="1">MDIYAGTKEARRNIPMEGEEAAAVEAALSDLPVEQSIVVVDQPVAEEDTKPALRDQVPINPPTFDTAGKILPPPPSADGTEMGTFQKAMLAVKMDARAFDTALDDLMELSHDIYYGLEIAKDGPIVEKLICLTLGSGSEKIPAGKAGREHKAASILASSVQNNPTALKEIVKWGRMVFHPICSEAKKGEKPNFVTTLRTRLGREKDAGALKAKVGAISGLLHDESFRTQFLENSGMELLLAIFLKKGEDFDPVRRKVAQLVTDNFLDEGMGAKVGVWPKMPVTEAKVCKENKERMLEDGCWEYHVGAFGEQKGKLAWVKEFEVLLTEQREKFGDSILDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTQ2</accession>
    <name>A0A194WTQ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_700758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065342.1">
        <property type="nucleotide sequence ID" value="XM_018217143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTQ2"/>
    <dbReference type="STRING" id="149040.A0A194WTQ2"/>
    <dbReference type="GeneID" id="28826869"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700758"/>
    <dbReference type="InParanoid" id="A0A194WTQ2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
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        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
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    </dbReference>
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        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443848" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="40"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="565" mass="59838" checksum="F6849F65D556CC83" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV07</accession>
    <name>A0A194WV07_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_785988</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222944.1"/>
    </dbReference>
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        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WV07"/>
    <dbReference type="GeneID" id="28832670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785988"/>
    <dbReference type="InParanoid" id="A0A194WV07"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
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    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="448"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="1216"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="310"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="590"/>
        </location>
    </feature>
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            <end position="1472"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1656"/>
            <end position="1769"/>
        </location>
    </feature>
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        <location>
            <begin position="1293"/>
            <end position="1322"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
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            <end position="107"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="160"/>
        </location>
    </feature>
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        <location>
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            <end position="176"/>
        </location>
    </feature>
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            <end position="191"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="1760"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ11803.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1821" mass="204577" checksum="A915FA0C35007A8A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW64</accession>
    <name>A0A194WW64_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_593912"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26667" checksum="E2D026B26275A36F" modified="2016-10-05" version="1" fragment="single">TKMRPAPFAILEGTASVSITSMKSASEYNYYGVLDQDKILEEASNFVSSNSDATKSEVEEILRHFITLTSNDYLEEKRRVFTIRMTKPTDEYTETPRWHRDGRMYTTDRPGEVNSKYATTLLGNPTRIMTESPLVKKVLDEEESIRMPSYEQDGAAYWAAAKEQEVRVAKRLAGQPLVGLPGGSIIKFSWDQVDSPVHSEPDMSTDRVFVSVLYGSEKEMRNMREIRQKEYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW82</accession>
    <name>A0A194WW82_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_688407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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        <location>
            <begin position="33"/>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="82" mass="9343" checksum="C02DB2B2CB7FCC40" modified="2016-10-05" version="1">MMCSHISHYLAMPWHKNINFVRCIILPTTNRHVSAFVAGVILLMLCCTSIHSLSQTNTQPLPLGKNWFLQLCQVALSHHLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0S2</accession>
    <name>A0A194X0S2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <end position="91"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="109" mass="12484" checksum="C464B099FDE72F18" modified="2016-10-05" version="1">MDLYQYDTTGNTMVTFLRNILSIPLYQFNAMMWQLPTSLNISELELPAENYVKGTYASSQLRSVPETWTVWTYIGLCAGMLLIILGIHGWAMQDEIPEKSAFPMPDLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0T8</accession>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="A0A194X0T8"/>
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    </dbReference>
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    </dbReference>
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            <end position="536"/>
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            <end position="52"/>
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            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="536" mass="57809" checksum="7520049B276B2808" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8590" checksum="A329DAEFF5E39492" modified="2016-10-05" version="1">MISSNSTSTLLHRYPVSHAHSSSFRFYSNVCLFSFPIFRWVVGFLLICFEEISSLVVLLLLKKKRGMGGRSQNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1F2</accession>
    <name>A0A194X1F2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_621763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13694" checksum="62DBC7EB3DEF2535" modified="2016-10-05" version="1">MVFGWGESQDAYQQAQSGDVNQASFGHEALAGAASFGAFKVFEDRQRAEGKPVSHQFAKEMLVGLVGGEVDKLAETKGMDWVDKEKAKRHAKENVQNMYDQQYGGNDQYDPNQQDTNQALNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2I0</accession>
    <name>A0A194X2I0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_698720</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_698720"/>
    <dbReference type="InParanoid" id="A0A194X2I0"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
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        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF406">
        <property type="entry name" value="PA AND RING FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
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    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ14556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="35061" checksum="51B75838BCDB5504" modified="2016-10-05" version="1">MAVSSIQDRTNEFRSVLVQVQKRQASSKVGAQRQSLLSDSQKAAANGDAKPKRSDFARRAADIGRGISATMGKLEKLAQLAKRKTLFDDRPVEINELTSIIKQDLSALNGQIGQLQALSRAQHPKADQEGEHNKNVVFLLQGKLTDVSANFKDVLEVRTKNIQASRARTENFVSSVSAHVAPQISQSASPLYSTPNRGSPGPGQDSLSLNPVGDQQLLMMEEAQPQNTYIQQRGEAIEAIERTISELGGIFGQLASMVSEQSEMIQRIDANTEDVVDNVQGAQRELLKYWSRVSGNRWLVAKMFGVLMIFFLLWVLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4N0</accession>
    <name>A0A194X4N0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_686434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069132.1">
        <property type="nucleotide sequence ID" value="XM_018215285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4N0"/>
    <dbReference type="GeneID" id="28825011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686434"/>
    <dbReference type="InParanoid" id="A0A194X4N0"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000017">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="480" mass="53335" checksum="4CF27975CFD53D1E" modified="2016-10-05" version="1">MASTSSGSYEPSPASTAPSSTTSDISTKDAHAASEKPPDDTSKLRMFLGILRKFIGVADIASVRFSLPAQLLEPTPNLEYWNYLDQPNTFVAIGDSDDAFDRMLEVLRFWFTKDLKYVKGKPCKPYNSTLGEFFRCNWEVEDAAPSITSIRSQSQTSSAASSIKGKKTPLASRNASSATIPRLDGAAFSSEKPSKKVKVSYLTEQTSHHPPVSAFFVDCPDKGLTARGFDQLSAKFTGTSIKVTPGEHNLGIFITLAKRDNEQYQLTHPAAHLGGLLRGSLSVTVGDQCYITCTKTKIKTILHYLEEGWLGKTQNKVEGVIFKYDPEKDDKTRIRDVPDKDVLARVSGNWKEKLYFSLGPKPDAPQILLIDLTPLTVAPKLLPPTTNQLPNESLRFWSGVTEAISNRQFSRATALKQELEERQRSKAKEREDAGREWQPRFFVGAVTPLGKPELTDDGREVLRGLQEERWELRENEELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4Q6</accession>
    <name>A0A194X4Q6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069511.1">
        <property type="nucleotide sequence ID" value="XM_018222672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4Q6"/>
    <dbReference type="GeneID" id="28832398"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783361"/>
    <dbReference type="InParanoid" id="A0A194X4Q6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267898" evidence="1">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="20393" checksum="7BE14E1B25351273" modified="2016-10-05" version="1">MRFTTSIIMASVAALVVAAPMKAKRQDEFSELLESNQLDNSNLDSLFSSNSLDVNDIAELLSDFDLNSFNSQFDSSFDNNNIEELLIELEGNSFGNSNINDINDVNSFNLDDFANSFNENFSGSWNSDEIEQLLLELGLVNSNSLDSNNEFFNSSDLSNEDDLFFNSSDLSDLESEIISTSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X537</accession>
    <name>A0A194X537_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_588434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069650.1">
        <property type="nucleotide sequence ID" value="XM_018209481.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X537"/>
    <dbReference type="GeneID" id="28819207"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588434"/>
    <dbReference type="InParanoid" id="A0A194X537"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
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    <dbReference type="InterPro" id="IPR035965">
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        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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        <location>
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        <location>
            <begin position="1048"/>
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        <location>
            <begin position="1268"/>
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        <location>
            <begin position="1819"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="574"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1538"/>
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        </source>
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    <sequence length="1952" mass="213269" checksum="28F577A1E153DA5C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5K3</accession>
    <name>A0A194X5K3_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">LY89DRAFT_686198</name>
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    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">CBS 120377</strain>
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    </reference>
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        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
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        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KUJ15451.1"/>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    <sequence length="94" mass="10344" checksum="3CAA8A667D5B8F76" modified="2016-10-05" version="1">MPETTIPPPPLAARPAKPVSEALLNEKWDRCLSSLLIRSSLGLSFGVVFSVLLFKRRAWPAFVGLGFGAGRAYEECNGSFLREGRKEGIRTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X613</accession>
    <name>A0A194X613_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">DUF7071 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_89504</name>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X613"/>
    <dbReference type="GeneID" id="28833224"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_89504"/>
    <dbReference type="InParanoid" id="A0A194X613"/>
    <dbReference type="OrthoDB" id="3592634at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055499">
        <property type="entry name" value="DUF7071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23257">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17938" checksum="2FB2F3167D8F27EA" modified="2016-10-05" version="1">MSSTLRRSTRQFHSRFDPVWDCPQYAPNQAPRYEASTRDQREAEDMARDILGEGLFEAPTVKIILKLQGARTAPFEWQAIRRALEIDEGAFTDIARLCFLLPQPQSEQSSRENKEDEIETGATGHLKDSLVQERGESRRHDWGRQTKRKYNWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X697</accession>
    <name>A0A194X697_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_670245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="28822873"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670245"/>
    <dbReference type="InParanoid" id="A0A194X697"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ15698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="17814" checksum="A43D348360B23FC1" modified="2016-10-05" version="1">MCDVLYLSLSGAVLHARGGMIVGSSHPRKGTVQQSKRGNDQMEEASILPEGLLAPDRSPWDSTTSLLSFYLPYPPSQCGHRAGDAIGGVTSGLDARKLGGLCTVSRNPQRREKPLSRHIRHIHHPTWPWIEMIACVRHGIEGIQVTDTMLESAATATAAAAAAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6J2</accession>
    <name>A0A194X6J2_MOLSC</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_685729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28824867"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685729"/>
    <dbReference type="InParanoid" id="A0A194X6J2"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="30468" checksum="C4553558E4B38FB0" modified="2016-10-05" version="1">MSNTKKTYFLAPNFHILPPPTGPLLLGSIISSVSKPEHILNRQPNYVPIPPSSPSFTHHQAGFSSTHSNSLSGSFGGFTALNAFLSSILSLRVDADLDGASSGSTIYKCKDLETTYFYPDDEYIAKNIEIKRVKDWMTDTYWKKPVYMITGLKIARGMKAESKQGKSLKGKVEVGVDATMLTGVPVSGGPKVGGGVEAKNGVSWDGSDDFIFAYRVVRIKLKGKEGGFEAGEHISGALYSEGDEGAKGNLRDEWDVSEIEDMEGEEIVAPHIICEEEPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6S7</accession>
    <name>A0A194X6S7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_685777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070231.1">
        <property type="nucleotide sequence ID" value="XM_018215146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28824872"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685777"/>
    <dbReference type="InParanoid" id="A0A194X6S7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="930"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="282"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="613"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="895"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1208"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1438" mass="158406" checksum="84C2B8820DBB59C1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X805</accession>
    <name>A0A194X805_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_79101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070648.1">
        <property type="nucleotide sequence ID" value="XM_018223407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X805"/>
    <dbReference type="GeneID" id="28833133"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_79101"/>
    <dbReference type="InParanoid" id="A0A194X805"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="305" mass="34919" checksum="2777101B73AA6792" modified="2016-10-05" version="1">MRGVELPKNPKFTSITSEVLSVPYNLQDASRYFDSDEIDPAMSDIIRTRLLAAAGLNDDAVSAEHQATAKRLNIKPISPNRDVNLFFTHNPTYCGSVALQLAADSEESGLRLANYHVVPTLIAHLYSETQRTRLLDAAWPEIDQFIGMHIADIFNGQRPQSAAEAFIKYTKTLGISTTTRLNRHQRENPFKEPNYSLLPVSDALRPYFEGKDTFAASVSKLEAVVQAHRQMITHTSKHKRRETRRKLTPIQFLGKMQHLLRRDTEASYRLHKSDQDLLPVDEANTFRDQDKCWNRLPSLQWRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X822</accession>
    <name>A0A194X822_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_685835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070307.1">
        <property type="nucleotide sequence ID" value="XM_018215154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X822"/>
    <dbReference type="FunCoup" id="A0A194X822">
        <property type="interactions" value="1070"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X822"/>
    <dbReference type="GeneID" id="28824880"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685835"/>
    <dbReference type="InParanoid" id="A0A194X822"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="473"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="275"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="570"/>
            <end position="572"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ15952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="614" mass="69600" checksum="D063CE75CC7E522D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8B1</accession>
    <name>A0A194X8B1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070760.1">
        <property type="nucleotide sequence ID" value="XM_018215073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8B1"/>
    <dbReference type="STRING" id="149040.A0A194X8B1"/>
    <dbReference type="GeneID" id="28824799"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685397"/>
    <dbReference type="InParanoid" id="A0A194X8B1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="27030" checksum="6EBD0A4C57F0B144" modified="2016-10-05" version="1">MSKTKKNVVFDVVGTCVSYDAFFNAIDERLGPKLRAEGIKPKLLGFAWMEAAEREYTYLSISGGYKSFWEVFQPLFYRMLWMAGIEEPRKFATDEDSLYMVEAYKKLDARPGLKECFEKLRGAGFKVWALTSGDTSRVRGYFERNGVDMPAENFTSCDSLGVGKPDPSVYAEVLKKFEGAEKPWFAAAHTWDAGAARRNGFRAAWCSVWEKEQCVDIFGDMDVTADSLPEMADKIIAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9R0</accession>
    <name>A0A194X9R0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_707312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071219.1">
        <property type="nucleotide sequence ID" value="XM_018217592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9R0"/>
    <dbReference type="FunCoup" id="A0A194X9R0">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9R0"/>
    <dbReference type="GeneID" id="28827318"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707312"/>
    <dbReference type="InParanoid" id="A0A194X9R0"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="148"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="414" mass="45878" checksum="95A0CAEBBDE2DEE1" modified="2016-10-05" version="1">MGDGATRKYGLLQDLLLIVVSSFSMYYIAKSVVASLPLGTDPEKEQHEQARVKATANLRRLGISRGEEDSEDESGRNTDSSRRPRKEDFNLDQYESQIAMEVVAPEDIPVGFDDIGGLDDIIEELKESVIYPLTMPHLYSQSSSLLAAPSGVLLYGPPGCGKTMLAKALAHESGACFINLHISTLTEKWYGDSNKLVRAVFSLARKLQPTIVFIDEIDAVLGQRRSGEHEASGMVKAEFMTLWDGLTSANAAGVQACIMILGATNRIQDIDEAILRRMPKKFPVSLPSNSQRRRILNLILKDTKIDEDNFDIEYLTRVMAGMSGSDIKEACRDAAMVPVREFIKEQRERGVAMSGVNPESVRGVRTEDFFGRKGGGQILKDNHARHSHKQTQKKPEASSEEYEDFDDEAAESMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAZ3</accession>
    <name>A0A194XAZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_706944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
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    </dbReference>
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    </evidence>
    <sequence length="348" mass="39447" checksum="293DA1DC25714A60" modified="2016-10-05" version="1">MMSKAPSDILAALPLPSIERPFGIQLWPIFDQAFRALMGYHPQDFDFQPRVTPMSTLKQSSLMILAYYIVILGGRELMRNRPAFKLNGLFMIHNFYLTAISGTLLALFLEQLIPTVYNHGIFYAICDVKGGWTPPLVILYYLNYLTKYLELIDTVFLVLKKKPLTFLHCYHHGATALLCYTQLIGLTSVSWVPITLNLMVHVVMYWYYFQSARGIRIWWKEWITRLQIIQFVIDLGFVYFASYTYFTSTYFPWMPNAGKCAGEEFAAFSGMGILTSYLVLFISFYIATYRKDGKKPTGRKAARSLGSLKDAQIPDIAALRAAASNGNAKTSSSSPNGNGRASTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB27</accession>
    <name>A0A194XB27_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_781590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1474"/>
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        </location>
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            <begin position="1654"/>
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        <location>
            <begin position="22"/>
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        <source>
            <dbReference type="EMBL" id="KUJ17376.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1713" mass="191051" checksum="6A685508670BCE39" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB37</accession>
    <name>A0A194XB37_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_781592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222494.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28832220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781592"/>
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    <dbReference type="OrthoDB" id="5333578at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF2">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268028" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="18131" checksum="BB1AF46FDB05A900" modified="2016-10-05" version="1">MSKLALLILALATTISAHFQINTPQWRDNSFNAPYSQYIYPCAGVPSNSSTNIINETGNGTLCIDKFTLPTELAVVDGQLASLQVVTVGETGAALYNCADIQFSSNASLLDAGSCSNSSGVSWDYLDLAGTSTTGGNATGTGAASTETAKSGALRAFGGVKVDVVIVGLVVGLAVLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC41</accession>
    <name>A0A194XC41_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_684686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072081.1">
        <property type="nucleotide sequence ID" value="XM_018214930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC41"/>
    <dbReference type="GeneID" id="28824656"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684686"/>
    <dbReference type="InParanoid" id="A0A194XC41"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF71">
        <property type="entry name" value="EPOXIDE HYDROLASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="513" mass="56966" checksum="ED318FC2CB70D73C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCR0</accession>
    <name>A0A194XCR0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_717602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072313.1">
        <property type="nucleotide sequence ID" value="XM_018218358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCR0"/>
    <dbReference type="GeneID" id="28828084"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717602"/>
    <dbReference type="InParanoid" id="A0A194XCR0"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31066" checksum="9C153D76E508F027" modified="2016-10-05" version="1">MAKAKQKKNKGAAPEKVESKPQSPKIRPLSSALVPRTKTHKPRPLSVASPPARVIVHLMRHAEAQKKTDIFGPKLRDPSLSDVGRAQCSTFVEEFKDHQSHVTHILCSPMKRAINTAVVAFPDVVGKSLTVYAMPELQSLDRGPGGIGASFSRLSKKYRVKEGEMPKVDVTTFGRKGWNDKEYGAWSPSEAHRRVDFIKGFLRGLLAAATSKIIEVVIITHRSFLKQLCRSAKTGFMVFSTCALFQDGELRPIGDRELKKLRDGESLSLEVPDEGPKEENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCU5</accession>
    <name>A0A194XCU5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_733418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071932.1">
        <property type="nucleotide sequence ID" value="XM_018219797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCU5"/>
    <dbReference type="GeneID" id="28829523"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733418"/>
    <dbReference type="InParanoid" id="A0A194XCU5"/>
    <dbReference type="OrthoDB" id="5412634at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="377" mass="41554" checksum="F7D0D75A16E66F4C" modified="2016-10-05" version="1">MATNVYDSNGWDMIAATTQDDITLGAPQLQVKVGSGSQVDVLIPITGSIKLNGTSIELLGQEIIVTTDLLQVEAEVDPHPGENQTTYDLMFNLREGFIVDINLEMPAAGYAFLIIALKQIIKDYLGTGKQYILASFTLTAAEEAEYKPLIPRLADFTFVYDPTTPSRSNFLVLMQTVSPGLGNMYFNAPILAPTQDYLVLVSNRLFLEYIVMPALITGLKKEIINTDTHIELDKDNDPWISKLTGSIDTSMQALELFLEYKADVTFVQVHVDAWDNSWQQFAIDDQGNITLKQINEEQNKSTILEWWKWLIAGGASLYAVIAVGIIDLVVTADAPGLGGTFADIGTTALIKWPNQKTIVLKSITTPGHIVMDLEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE23</accession>
    <name>A0A194XE23_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_47483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072756.1">
        <property type="nucleotide sequence ID" value="XM_018207801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE23"/>
    <dbReference type="GeneID" id="28817527"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_47483"/>
    <dbReference type="InParanoid" id="A0A194XE23"/>
    <dbReference type="OrthoDB" id="3945172at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="11473" checksum="6348BA06B3EE2A87" modified="2016-10-05" version="1">MLPQTRHLARLAFPRRVPSTTRPLSTTSLSAKWEGSKPSDHITNENDSHNVRHDAHKEGQQERQKGDGSRGTSEQAGDANKKAKEEFPEAPDTVGMQDERGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE67</accession>
    <name>A0A194XE67_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydrodipicolinate synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_706903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072791.1">
        <property type="nucleotide sequence ID" value="XM_018217558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE67"/>
    <dbReference type="STRING" id="149040.A0A194XE67"/>
    <dbReference type="GeneID" id="28827284"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706903"/>
    <dbReference type="InParanoid" id="A0A194XE67"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="35040" checksum="843357E2CA8BE8D8" modified="2016-10-05" version="1">MATPPPAGIYVPVPTFFVSKKAANYSPTAAPLDLETQAAHSLHLAKSGITGLVVLGSTGEAVHLSNKERFAVLSSVRKAYEDAGFKDYPLIAGTAAQNIEEIVEQLKSAKEAGCQWGLCLVPGYFAGASTQDGIIQWFTAVADQSPIPVMVYHYPGVSNNVKVVPSTYATLSKHPNIVGCKLSHGDVSYHAQIGANPKIDHTHFHTFTGLGQQLLPVISLGCAGTIDGTAGFFPKSVVHLYKLSVNNRPTDEEVKERRLLQYKLSAVEELVVKFGTVGIKEAISRILGMGDRDGTRLPLTGGIPGGDKEWENWEECVGDLDAVEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEA7</accession>
    <name>A0A194XEA7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_717131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072875.1">
        <property type="nucleotide sequence ID" value="XM_018218324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEA7"/>
    <dbReference type="GeneID" id="28828050"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717131"/>
    <dbReference type="InParanoid" id="A0A194XEA7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="285" mass="32015" checksum="A3E9E60489BCBB93" modified="2016-10-05" version="1">MYKKIRLPINCLQVGLCVAGAFPDYFTDLWGRGYSDTPLDCRHDVRLFASQILLALMSSPLSWMGNSNTFFIVAFSLGGLISLAFTGAFPESVRSLVLLGPAGLIRKRPDGYDDNYMHQPKLAPSLESLRENVRQILGAIPCGPALNMQTDKKRVVSSEQGPPRVEKSFDIGGIIQWQFDHHQGHIHSFQDTVRYGPLQKREDLWGKVCDIIAGRTRPDSALHNTKLLVFFGRDDDVVVGEETTEDILKLLGRIPTRWAWVPLYPNSEKITQTILSFQRSKLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEG2</accession>
    <name>A0A194XEG2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_717156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072918.1">
        <property type="nucleotide sequence ID" value="XM_018218326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEG2"/>
    <dbReference type="GeneID" id="28828052"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717156"/>
    <dbReference type="InParanoid" id="A0A194XEG2"/>
    <dbReference type="OrthoDB" id="3565308at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="214" mass="21748" checksum="5D41A88934E2F55A" modified="2016-10-05" version="1">MMEGSMCAIDSYICSSKVEAWILNYGGAGMTPPSPESGNQGGQDSYGSSGNSDSYGGSNNNQDQDSYGSSNSSGGGNQDSYGSSGNSDSYGGGNSGNQNSYGSSGNQDDGSSDQSSGGYGGQSGGQQGGQQQQGQGQSGQQGGQQGGQQQGSSGGGGYISQGLNFLEQKTGHNLSQQQNEELTSGAKSAYQQVTGFVHPLMLSFFRIFCPLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XES1</accession>
    <name>A0A194XES1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_643041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072994.1">
        <property type="nucleotide sequence ID" value="XM_018211780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XES1"/>
    <dbReference type="FunCoup" id="A0A194XES1">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="GeneID" id="28821506"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643041"/>
    <dbReference type="InParanoid" id="A0A194XES1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="59"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="49886" checksum="02A643469A06B428" modified="2016-10-05" version="1">MSSLQKTEHNVKSNDIKASQEPIELQVRNLAIEGVTEEPTSPTNITDAENISPPLPLLKLLSSGVSFLVAGINDGSLGALIPYMLSTYHISTSMISLIYFTTFLGWLVCALTNTHLTKLFPLGTLLAIGALIQVIPHTLRAWTPPFALYVVTFFMSGLGQAYQDSHANTFVSTVKGAHRWLGFIHACYGLGLLISPFVATSIAVKTQHENGKWMLFYLFPLGLSVTNLALVLVAFRDSVHLSQIIDQEGLSDPEREGRSRAAASEVKQMLKIRDLWVFCLFFFFYLGVCTTSGGWIVEFLVRVRHGELSEMGYVPSGSYGGIFLGRLLLAEPTHRYGERRMLLLYAGICFALQLVFWLVPNLISSIAMFSIMGFFLGPFFAAGVSVASKIFPKHLQPAALGMIFVMAQAGGAIFPSLIGVIASHAGVKVLPPIVAGLIVVMSVTWAFVPKVDEHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFE4</accession>
    <name>A0A194XFE4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_553410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073270.1">
        <property type="nucleotide sequence ID" value="XM_018208334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFE4"/>
    <dbReference type="GeneID" id="28818060"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_553410"/>
    <dbReference type="InParanoid" id="A0A194XFE4"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16583" checksum="641D0FD0E1D6BE4D" modified="2016-10-05" version="1" fragment="single">MSFGYSIGDALSLLNLAFQTLQNTRRACGEHDDLTREVSSLHRVLHRLHLELLNPHSVLNRADDDRHAELNELGESCEQILRLMNSIVTKYNALWDGSIWTNVDGDEKMFWRELRRGLVKEGYRSSVLQRHKHLIQDYIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFV5</accession>
    <name>A0A194XFV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_475540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073408.1">
        <property type="nucleotide sequence ID" value="XM_018207806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFV5"/>
    <dbReference type="GeneID" id="28817532"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_475540"/>
    <dbReference type="InParanoid" id="A0A194XFV5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14950" checksum="C8E90009EED9E527" modified="2016-10-05" version="1">MKRLRGCSRCRPLRCLRPCPISRTSEHLMRTSRAHQPLFSFLPAVAQTFLIPTTRSSTRSSGDNTATISNPCLGSFGTSVFIPLWVASFVHHNRRDPARGGQSNPNHRLPPLRSQKVEDSWQRPWSDTPICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG95</accession>
    <name>A0A194XG95_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosinase</fullName>
            <ecNumber evidence="2">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_731629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073570.1">
        <property type="nucleotide sequence ID" value="XM_018219587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG95"/>
    <dbReference type="STRING" id="149040.A0A194XG95"/>
    <dbReference type="GeneID" id="28829313"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731629"/>
    <dbReference type="InParanoid" id="A0A194XG95"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="39345" checksum="65867EC682D951BB" modified="2016-10-05" version="1">MTHDGRSLYLQALIALQQTSEDELLSWFQIAGIHGRPFIPWDGIEWNPSAPEVGYCPHSSVLFTSWHRIYLALLEQVLSSHAQHLAKTYNSTTYQIAADNFRIPYWDYALTPSMPDIVDYPQVLINTSSGPMNVSNPLLHYRFQQFPLNETLFPAGESGEGCLTTYNTTVRFPVNGVSNCDSINANLQGSNLKANTYSVFQTRDYNTMATGTTSNSAFEYAHNQVHHTIGGFNTMDPGHMGVFAYAAFDPIFFLVHANADRLFALWQAMNPTSFLTPDIDSTGTFTNVVGGNLTVDSPLTPFTMVNGSAWTSTGARDLVGLGYSYPEIMDWLPISKDDLAKNVTAAVEWMYGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH16</accession>
    <name>A0A194XH16_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_683294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073813.1">
        <property type="nucleotide sequence ID" value="XM_018214676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH16"/>
    <dbReference type="STRING" id="149040.A0A194XH16"/>
    <dbReference type="GeneID" id="28824402"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683294"/>
    <dbReference type="InParanoid" id="A0A194XH16"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="442" mass="47947" checksum="7FEFA24FBBB30072" modified="2016-10-05" version="1">MPSAISRSEQISEALAAARATYGKSNPESQKINSESSLSLPGGTTRNVVHFKPFPLILESGKGSYLTDVDGHTYLDLCGEYSAAMFGHSHPVITKAMHSAIESGFALGGVNRFEGRLGKLFCSRFPSIEKIRFSNSGTEANLTAIALVKAYTKRNTILVFKGGYHGGLATFSKDDKVTANSMNAPHNFVIAPYNDIQAFHDLVAKHKDDLACIFLELMQGSSGCLPADIEFIKATRAKAIEVGAILMFDEVMTSRMSTGGLQSLLGVTPDMTTLGKFFAGGGQNFGAFGGKNEIMSIIEPGHPGGAYHSGTYNNNVTTMAAGVAVLEQVWTKEAADDLYKMGEWLQKELERASKEAGSTLKVTGVGSLMTLHFSKNEVRSAADVQASETNVRELFFFDMLKKGLYLAQRGMISLMTVTTKEELETFVEAVKEFLVERREFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHH7</accession>
    <name>A0A194XHH7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_667522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073941.1">
        <property type="nucleotide sequence ID" value="XM_018212980.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XHH7"/>
    <dbReference type="GeneID" id="28822706"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667522"/>
    <dbReference type="InParanoid" id="A0A194XHH7"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="857"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1247"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1269"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1291" mass="137765" checksum="C2E470343BED3E61" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHJ4</accession>
    <name>A0A194XHJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_780236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073602.1">
        <property type="nucleotide sequence ID" value="XM_018222363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHJ4"/>
    <dbReference type="GeneID" id="28832089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780236"/>
    <dbReference type="InParanoid" id="A0A194XHJ4"/>
    <dbReference type="OrthoDB" id="2537245at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="445" mass="50187" checksum="482A2AAFF29FC071" modified="2016-10-05" version="1">MASPLKAHVPAQLPTLPRDLGSDELHVCFIPSKPDFRRSCLEAVGRDESKLPPPLISCSDFVPRRLVELLMRKKKDSALGVKFLHTKKGDQITDMEGAMHTFVTPIVPRCEMVGDYRYDPQLGGHGVNMFGEQTLRGLDGHDKGKCRVTRSVVMSGSIQMDFENSKVMLRVCKLGDHTVVGQNLLTDKAWEILDSKPKQDDTQRYEYDEELRRHMIYHLTKEKKLPRRRDIEHALDDEKTIKFLETLIMTPGNTTEKVVGVFSKLHNDQIVSLELLFNTALHQVRNEFAALEALCPRGHVYTYDPASIFAREIGPEILNRLMLAALRHLSDNHKFENMRVFAFNDYADRGALNLVRSALKNQKRVQVVSKQELFRGPGGPGGLYDVTDIQGAEGAMLVIHNNSDGFGQNIETERMYGSLDGAIGSCSSAAASLRRDRKDLLDFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHL0</accession>
    <name>A0A194XHL0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_456835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073976.1">
        <property type="nucleotide sequence ID" value="XM_018207642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHL0"/>
    <dbReference type="STRING" id="149040.A0A194XHL0"/>
    <dbReference type="GeneID" id="28817368"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_456835"/>
    <dbReference type="InParanoid" id="A0A194XHL0"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052963">
        <property type="entry name" value="Pantetheine_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36492:SF2">
        <property type="entry name" value="[ACYL-CARRIER-PROTEIN] PHOSPHODIESTERASE PPTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="35249" checksum="EC98C048B35142FC" modified="2016-10-05" version="1">MSQSKPQRRLPTGKLYAIADIHIAFPANREAWSKLTRHPGDGLVLCGDIGETIEHLQLAFSTATRCFDTVWWCPGNHELYTLPTGSSVRGEHKYEQCVDVARQYGVFTPEDDFIVWEGQGGPAIIAPIFTLYDYSFRPDEVTLENAVPWAREKDTEATDEFLLHPDPYPTRQDWCKILVQKFEAKLEAAKAQHPLLPFIIANHWPLRKDLVHLKYIPRFILWCGTTLTDNWHERFNAKVVISGHLHIRRTDWKGGCRFEEVSLGYPRHWKDCADMDMGVNEILREILPGPETPEGGELPTQWRRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHZ9</accession>
    <name>A0A194XHZ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_462934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074200.1">
        <property type="nucleotide sequence ID" value="XM_018207701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHZ9"/>
    <dbReference type="GeneID" id="28817427"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_462934"/>
    <dbReference type="InParanoid" id="A0A194XHZ9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12550" checksum="E54BB5AF0C3D4547" modified="2016-10-05" version="1">MKCFTKAAQAWLCLSAVPPPPSLVHQKWISGFHMTKHRAIQRIKVGEEVVWVFAFIFDLSMYLRTLYSTEAIVSICPHHGVRRPLFPIRHTMQRPQNPRLQGKWSVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIG9</accession>
    <name>A0A194XIG9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074380.1">
        <property type="nucleotide sequence ID" value="XM_018222338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIG9"/>
    <dbReference type="GeneID" id="28832064"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779890"/>
    <dbReference type="InParanoid" id="A0A194XIG9"/>
    <dbReference type="OrthoDB" id="5154006at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47536" checksum="7F69CA799236E08E" modified="2016-10-05" version="1">MPTNNTKKKIELSFTNWVLGGNLISVVEAKSKSSKNGMTTDRATARKMYLVNEDGTQEIADESLIPSKGKRVGKKARIEVTTKTETKEECDIPEAKAPETYEKWCEKCKTPCCEGAVAGAVPAGAKTALCECGKYHWICQYEAYDADTEKEKGDEEKKSGGGKKKKDEEKGKDVEVVVDAVVEEKSDDKKEDGVKDKDNSDEKTATSDEWTAEQDKTILEMKADNKSWKEIVAAVGSSKQAVVNRFKELKKAETEQPSKPAAEETTDKNDNKVIDDAFGADLFAGDENDNGGGSHEKDDAEIIAGLETLLDGFNDNEDKATKKGNKKNKGKKQQANAADPNTSSFDNNQGTNSPAQDPLGISFGPQLYGKLVPDATWSKDDCDLLEHLLERYESEKWLHMQANFYNWTGRMVAAEFIERKFKTDASDSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIQ9</accession>
    <name>A0A194XIQ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_682907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074475.1">
        <property type="nucleotide sequence ID" value="XM_018214597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIQ9"/>
    <dbReference type="FunCoup" id="A0A194XIQ9">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIQ9"/>
    <dbReference type="GeneID" id="28824323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682907"/>
    <dbReference type="InParanoid" id="A0A194XIQ9"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="171" mass="18696" checksum="B5862C590A0BD801" modified="2016-10-05" version="1">MSEERLWKFRKPEWMNSATARSAGVYGAGALFSLAFFTLLDAAVWSHSSRNGSNIHINFIDWLPLIFSSLGMLIINSIEKTRLSADSFSYSGSGVAWKARVVLFLGFASLAGGMAGGVTVLVLKYVVPQAPWPTVYMGIANVVSNGLVMLSSVVLWISQNMEDEYSYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKQ4</accession>
    <name>A0A194XKQ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_682440</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075098.1">
        <property type="nucleotide sequence ID" value="XM_018214512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKQ4"/>
    <dbReference type="FunCoup" id="A0A194XKQ4">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKQ4"/>
    <dbReference type="GeneID" id="28824238"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682440"/>
    <dbReference type="InParanoid" id="A0A194XKQ4"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ20743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="144" mass="16053" checksum="E50F4CDB33422D38" modified="2016-10-05" version="1">MLTPCQAHRIITQVVVTGTRVFSRACAEAWKQASASAQYAKAQAKNNPGAANTFASQGLTLEEACKILNVKPPQNGKANIEDVTERFKKLFDVNDPKKGGSFYLQSKVLRARERIEAEVRSATEKAERESELKEGWKPKVFKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL50</accession>
    <name>A0A194XL50_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription regulator PAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_420751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075315.1">
        <property type="nucleotide sequence ID" value="XM_018207404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL50"/>
    <dbReference type="STRING" id="149040.A0A194XL50"/>
    <dbReference type="GeneID" id="28817130"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_420751"/>
    <dbReference type="InParanoid" id="A0A194XL50"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="45515" checksum="8C2D6F8EA4714D2E" modified="2016-10-05" version="1">MHPGSAPSYGAHHSTHNGYYAPQQPSSYAPVYYPVSHGNDLGQHAAYDGRKRGYDALNEFFGDAKRRQIDPSSYAQVGQRLMALQGLPIHGGGISEYIPAGPALISVDGHGGHHSAHMPQHQYALPLPAVRTKADLMNIDQFLEQMQSTVYENSNAAAAAGIQQPGAHYTHSAVNFRQSHSPPQTALHGLGHMNSHVSSAHVTAPMMATHSSQSTSSGTPALTPPSSSVSYTSGHSPVSSHGMSPTSRHSSTTGGSAAYPTLPAVSLGYSPHAQTAPTSTLGTNFDSDPRRRYSGGMLQRQAPRSSEMMDTSDDSPTPSPKVATTPTLSREVTNNIDPALSGVTSPTGTSQSDSGESARDRAEELWIENIRVVEALRKYIGDRLERKEYIEEEEDVSMSGTGEEKREEKKEEESLYPVLRADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL57</accession>
    <name>A0A194XL57_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_416699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075221.1">
        <property type="nucleotide sequence ID" value="XM_018207376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL57"/>
    <dbReference type="GeneID" id="28817102"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_416699"/>
    <dbReference type="InParanoid" id="A0A194XL57"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19711" checksum="FC39BD6945A11C58" modified="2016-10-05" version="1">MDDPMKLDADTKAKIRKVNASNAHRDSTPAQSCMSKQGNRSCDDVGHSVESLAMQKNSRRMPLSAMFQHSETVFENKFIETLRSEPVQRHVSMVKLQCTTLILACQKYGGMLLQLEENAQECFVSRFEGYTVLERVSCDHKEAGITSLWQFFHHYNDMDCFQFSYHRHIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL79</accession>
    <name>A0A194XL79_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_730568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074887.1">
        <property type="nucleotide sequence ID" value="XM_018219492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL79"/>
    <dbReference type="STRING" id="149040.A0A194XL79"/>
    <dbReference type="GeneID" id="28829218"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730568"/>
    <dbReference type="InParanoid" id="A0A194XL79"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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        </submittedName>
    </protein>
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    </gene>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21144.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11000" checksum="C657DC7844587BB0" modified="2016-10-05" version="1">MVYPETFSGFQIEDPKKWTEFHLNEFKPKPFGDHDVDIKILACGVCASDLHTISGGWGEQHFPLCVGHGISSLVLRRFLVLERPWRGRLGGHGLVGVQ</sequence>
</entry>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SLL1358 PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="416" mass="45049" checksum="ACD852CBE6614EA7" modified="2016-10-05" version="1">MWFPNAVALLSAAVAVSSTPVTESGAHALEKRSGPQFAQGEPIDGSGKGGPILGGTNHQLDIQNPDNLGAHTTDNGLLPNLKWSFSESKTRIFNGGWTREQIISDLPASTDIAGAQQHLEKGASRELHWHRVAEWGYLYSGSVLLSAVDENGDYQVDKLEVGDIWYFPKGSAHTVQGLDDDNEYLLVFDDGNFEASGTTFMVDDWIAHTPKSILAQNFGVNESIFSTIPTPDPYILNGTVSNVNTTGPGSGLYGNSSYVFHHSQKEVVSVPGGGGNLSIVDSRNFPIATTIAAAIVSLEPGGLRELHWHPNAQEWLYFHQGQAQATVFIGGANARTFDFTAGDTAVFPDNSGHYIKNIGTENLVWIEIYRSDRVADISLTQWLALTPANIVANTLKIPLNVVQQLKKQKQLLIKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMF6</accession>
    <name>A0A194XMF6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075785.1">
        <property type="nucleotide sequence ID" value="XM_018214406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMF6"/>
    <dbReference type="GeneID" id="28824132"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681936"/>
    <dbReference type="InParanoid" id="A0A194XMF6"/>
    <dbReference type="OrthoDB" id="3561107at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="227" mass="25174" checksum="D2CBA06D0C351740" modified="2016-10-05" version="1">MAYTQSKRSKKNLDSEEEDTTLLGKISLLPDLASQPGENNQNQSGWTYTATFGVFKQCLALVIQVLCSVIVSNYSQSHSGKGLDRMRRISEYVELNNGHKFPWLSSSHTSADARRQASVIVDCPTMVSVPMVFLDPSPVTFMSAIMIYSSAVLLFCMLGQGQYRDHFLIFGCLLGTVLGILASWTQSNLEPLRDYIPLSITAGLTLSLIWQGLMSALSRKKRIRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMS7</accession>
    <name>A0A194XMS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_770755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075749.1">
        <property type="nucleotide sequence ID" value="XM_018221865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMS7"/>
    <dbReference type="GeneID" id="28831591"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770755"/>
    <dbReference type="InParanoid" id="A0A194XMS7"/>
    <dbReference type="OrthoDB" id="10468512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27881" checksum="2676B74B119260E4" modified="2016-10-05" version="1">MAYEHQIELIFDKASEYGVTVDTIAKHYRTCLRKIQTDRVDLNIHIQFYYAECQTWYFFFENFPGIEPSSSISDPKVINTSILANTSTEGGLVGMTTRHENAAKKIYDHAKAMNIIAKQSAEQYQSKCNKVVELQTLRSSNTSTAGLEKRIKKLEGELKHERNVTREKGDMLKALKKSSGIQKEKFRNLGRKVISKLERKGVDVTKLLEDLKAIDATEELPEIEEEDVVATTNAAVQEATDSLFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNB1</accession>
    <name>A0A194XNB1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AMP dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_705099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075587.1">
        <property type="nucleotide sequence ID" value="XM_018217427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNB1"/>
    <dbReference type="STRING" id="149040.A0A194XNB1"/>
    <dbReference type="GeneID" id="28827153"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705099"/>
    <dbReference type="InParanoid" id="A0A194XNB1"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="204"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="640"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ21232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="733" mass="82139" checksum="5322696E139B8ED9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNN3</accession>
    <name>A0A194XNN3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_383983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076133.1">
        <property type="nucleotide sequence ID" value="XM_018207141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNN3"/>
    <dbReference type="GeneID" id="28816867"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_383983"/>
    <dbReference type="InParanoid" id="A0A194XNN3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="18928" checksum="4D11073014758CD6" modified="2016-10-05" version="1">MASFTQILRLSNFFLQHAPKSSLLCHLTSCFQFMSESCHLHLPCEIRVQARLSKATIPKSPSVNIKSRPRLHHQRWLASGMLTNLSVSRKPAVTSHASPQQIRFTMLIRSWEYSQRLSEAGLGIVSLLPLRGESAEKRADRAGFVRHRFQRLRRIPDDGLQVDGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNZ9</accession>
    <name>A0A194XNZ9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_681274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076268.1">
        <property type="nucleotide sequence ID" value="XM_018214251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNZ9"/>
    <dbReference type="STRING" id="149040.A0A194XNZ9"/>
    <dbReference type="GeneID" id="28823977"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681274"/>
    <dbReference type="InParanoid" id="A0A194XNZ9"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="19898" checksum="9A11F15A34B26104" modified="2016-10-05" version="1">MSSKRASMMPPAPKPPTSLSSSLVIAEHASLTGTKLITLGSNTVIHPRSKLSSAYAPITIGNSCIISERSQIGIQNEPDEEEADPVVIEDGVIIEVGAVVEGKRIGEGSVIEVNAKVGRGAVLGKHCKIGPLCEVAEGEVLPDYTVLFGNGMRRIDNSGVEDLKMKMVARQVEVLRKLIPSKIAKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ55</accession>
    <name>A0A194XQ55_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_292540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076646.1">
        <property type="nucleotide sequence ID" value="XM_018206522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ55"/>
    <dbReference type="FunCoup" id="A0A194XQ55">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQ55"/>
    <dbReference type="GeneID" id="28816248"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_292540"/>
    <dbReference type="InParanoid" id="A0A194XQ55"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ22291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="418" mass="46595" checksum="CF5B2E172B3571C0" modified="2016-10-05" version="1">MSFSNMLNKLHGQPESYDKKAKYRFGRTLGAGTYGIVREADGPTGKVAVKIILKKNVKGNEQMVYDELEMLQRMKHPHIVKFVDWFESRDKYYIVTQLATGGELFDRICEQGRFTEKDASQTIRQVLEAVDYLHDNNVVHRDLKPENLLYLTSAPNSDLVLADFGIAKMLDSKDEVLTTMAGSFGYAAPEVMLKKGHGKPVDMWSMGVITYTLLCGYSPFRSENLQDLIEECSNARVIFHERYWKDVSDDAKDFIGHLLQPDADDRSTSKQALRHPWLSGENATDHNLLPEIRAYMAKARLRRGIELVKLANRIEALKIHEDESDQAPGESDVPADAKAAAGDALANPAGHSSTGLSTSTAAGSAPGGKKSLSNIAKGAIFREVVLAKVREMKESEKQLQVEKEATENAKRKSFQSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ76</accession>
    <name>A0A194XQ76_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_388345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076252.1">
        <property type="nucleotide sequence ID" value="XM_018207163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ76"/>
    <dbReference type="STRING" id="149040.A0A194XQ76"/>
    <dbReference type="GeneID" id="28816889"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_388345"/>
    <dbReference type="InParanoid" id="A0A194XQ76"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF162">
        <property type="entry name" value="RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="169" mass="18520" checksum="EF21F9F2A30F74BD" modified="2016-10-05" version="1">MSSIARSDHHIEYMRQALELARKSPPKPTNYRVGALLVDASADTILASGYTLECEGNTHAEQSCFIKLAGEHEVAEEDLASILPKQTVLYTTVEPCFKRLSGNLPCVQRILRLGKAIKTVYVGVKEPEKFVGENTGRKQLEDAGINVVLVEGMEKEILEVATAGHVRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQM5</accession>
    <name>A0A194XQM5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_681359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076377.1">
        <property type="nucleotide sequence ID" value="XM_018214276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQM5"/>
    <dbReference type="STRING" id="149040.A0A194XQM5"/>
    <dbReference type="GeneID" id="28824002"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681359"/>
    <dbReference type="InParanoid" id="A0A194XQM5"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="236" mass="25398" checksum="1A3B98AEE3D051E4" modified="2016-10-05" version="1">MPSIRPISRPTIRELSNFLLSPPTQPRCISHLTRRAPHPPKLPSTPRNLSSTSFLTASPKPQTRDRGPASTEDTQTDFGALNVLGNTPIPSTSIDACLWDGFHLDSGVKITGGTGVLLIAGEAFSWRPWEAVAAGGEGSLKLVNGKGQWDVGEEAWGVLELVWPKPDLLILGLGKDMRPISPRVRQYINSLGIRVDIQDTRNAAAQYNLLATERGIGNVAAALVPIGWREDVGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSN0</accession>
    <name>A0A194XSN0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_680079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077665.1">
        <property type="nucleotide sequence ID" value="XM_018214006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSN0"/>
    <dbReference type="FunCoup" id="A0A194XSN0">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSN0"/>
    <dbReference type="GeneID" id="28823732"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680079"/>
    <dbReference type="InParanoid" id="A0A194XSN0"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="346"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ23310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="551" mass="61184" checksum="B548C7755C075964" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSN6</accession>
    <name>A0A194XSN6_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_777792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077097.1">
        <property type="nucleotide sequence ID" value="XM_018222164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSN6"/>
    <dbReference type="GeneID" id="28831890"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777792"/>
    <dbReference type="InParanoid" id="A0A194XSN6"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="525"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="680"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="815"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="968"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124364" checksum="602A9B1A06CFAD29" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTQ8</accession>
    <name>A0A194XTQ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_680180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077779.1">
        <property type="nucleotide sequence ID" value="XM_018214026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTQ8"/>
    <dbReference type="FunCoup" id="A0A194XTQ8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="GeneID" id="28823752"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680180"/>
    <dbReference type="InParanoid" id="A0A194XTQ8"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="308" mass="34082" checksum="822F34AF8F6AE4D6" modified="2016-10-05" version="1">MITRLPTRIRLVSLASRPVSRSAIRCTHHIKSRPTAPRQLLLKSQHTRFYTPPPGSPPLESPQNPANLQSILPENHPPPPPSPKRSLKPYIYAATFFLLGTLLGQYTSLVLAPPPLPLPSTAEDNLMVSMIQNRASRLPIVQSLSNDPAWTHHDAYTSLPEHERAKRLTTGPLAGARGIGGYQRIFFNKESGETVTVIWMGGALAGWPGVTHGGVIATVMDESLGRCAIRRFKEKTGVTANLELDYLKPVVTNSFYVVRATPRVEGEAERKCWVTARLETLEGRVCVEAKALFVVPKRYRTREIGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU48</accession>
    <name>A0A194XU48_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_776072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078200.1">
        <property type="nucleotide sequence ID" value="XM_018222006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU48"/>
    <dbReference type="GeneID" id="28831732"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776072"/>
    <dbReference type="InParanoid" id="A0A194XU48"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="122"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="34810" checksum="EFA271715E78324D" modified="2016-10-05" version="1">MPLTAMELEQKAQDRAGVETRAKSIGIPSALLAALEKSKPTRSIPQETLSLLSETPQTIYRSLSNLVNPPSSSLTWKAHDHGVPTGFFRLPLEIREQIYGLVTGHKTVLKIPENYHKPRPSRERSNNGSTSLLQTCRQIYAEAITSIYTQNTFQFQNHNDFLAFAHAINPISLSQITSLTFDLNSILRVGGDPYDHQAPRFTIIWVDGVEAQWPHVWSIIAAMDNLMELNVFLQDPGFPEWDGMQCLCLFEREILSPLGKIKKRLRVFEMNVPWVDISSWDRFENRQPVTEGALFNLTRRGINPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU57</accession>
    <name>A0A194XU57_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_542673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078098.1">
        <property type="nucleotide sequence ID" value="XM_018208201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU57"/>
    <dbReference type="GeneID" id="28817927"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_542673"/>
    <dbReference type="InParanoid" id="A0A194XU57"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="11433" checksum="D969B247FED09D5C" modified="2016-10-05" version="1" fragment="single">EKILRWLANLDPFTNQRNASKQHEPGTGNWLLQRDDFLTWRSTPGTVMWLHGIAGCGKTVIWFAFCQSHAAQLVIFYFDFRDPWKQNADGLLLSILAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUE2</accession>
    <name>A0A194XUE2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_714059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078009.1">
        <property type="nucleotide sequence ID" value="XM_018218100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUE2"/>
    <dbReference type="GeneID" id="28827826"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714059"/>
    <dbReference type="InParanoid" id="A0A194XUE2"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="67023" checksum="68C78ED21257E830" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUM0</accession>
    <name>A0A194XUM0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_679187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078263.1">
        <property type="nucleotide sequence ID" value="XM_018213822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUM0"/>
    <dbReference type="FunCoup" id="A0A194XUM0">
        <property type="interactions" value="873"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUM0"/>
    <dbReference type="GeneID" id="28823548"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679187"/>
    <dbReference type="InParanoid" id="A0A194XUM0"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="16228" checksum="03863003174C9E0C" modified="2016-10-05" version="1">MMSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNTYIIPEAAVHGFLTFLFLINGYWLALVLNLPLLAFNVKKIVDNAHLLDATEIFRKLNVHKKESFIKLGFHLIMFFFYLYSMIVALIRDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUS8</accession>
    <name>A0A194XUS8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_712919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078318.1">
        <property type="nucleotide sequence ID" value="XM_018218011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUS8"/>
    <dbReference type="GeneID" id="28827737"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712919"/>
    <dbReference type="InParanoid" id="A0A194XUS8"/>
    <dbReference type="OrthoDB" id="3598207at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="165" mass="18372" checksum="79FE2A94AAA42145" modified="2016-10-05" version="1">MPTLSEHSTSMASSRGDQNDNSQPTVPPPQDQPSQSTPTSQGNHADQAAPSTEQGVNYCVATWRPGDSTIVCTPEQLAIWQEGMRLAALGPLPDPDEDDFLDEPLSKPFDPNWEPDWAKADAWIEEKDSEGRTLWRNRIIHFVSYSEPLEVREARDRLQKANSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUT3</accession>
    <name>A0A194XUT3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_679232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078323.1">
        <property type="nucleotide sequence ID" value="XM_018213830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUT3"/>
    <dbReference type="GeneID" id="28823556"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679232"/>
    <dbReference type="InParanoid" id="A0A194XUT3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="20836" checksum="C91860B84894769B" modified="2016-10-05" version="1" fragment="single">MSSLSRRTSSMNASSWMYQFIDKSKVTSPHTPRSGPGSLHHRPCCSFFEGQSLTPENKTCHECGYSQAHHLARFSLSDDLDLIDTRLQDAFGNTPLHHAAAAGNTLRVIQLMSMAGRILTPGLHHRNADGQTYLHVLRIENPQDFPDLMTILQHAKEQGVRLSERDHSGSTVKMKLQQLVLDCNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV36</accession>
    <name>A0A194XV36_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_679263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078356.1">
        <property type="nucleotide sequence ID" value="XM_018213836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV36"/>
    <dbReference type="GeneID" id="28823562"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679263"/>
    <dbReference type="InParanoid" id="A0A194XV36"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="38449" checksum="2EE1A728363B9C8B" modified="2016-10-05" version="1">MPPTIPNRQWTSHLNGISNLTLTQTTTSHPATNEVLVRITAISLNYKDGETISGQFNHHAAVSLPSTIVPCSDAAGQVWEVGDGVTRWKKGDRVLALPYLEYKTGRITQEMLGSGIGSSGKGVSCEYRIFEEDALLPVPESMSDEEACTMTVAGITAWMAMNGQRPLGSPGGQEEVVLIQGTGGVSIQGLQIAKASGATVIITSSSDEKLARAKALGADYTINYKTTPDWDVEVLRLTSGRGADIIFENGGAPTTAKSFNCIRFGGLFNAIGYVSGKVDPKDEEKTNINVQAIRKNVILVGMLNGPRDRVVEMLEFYENHGIKPVIDRVFKFEEAKEALQYLWSGSHFGTVVVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV56</accession>
    <name>A0A194XV56_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_744973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078565.1">
        <property type="nucleotide sequence ID" value="XM_018221046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV56"/>
    <dbReference type="GeneID" id="28830772"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744973"/>
    <dbReference type="InParanoid" id="A0A194XV56"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="125" mass="14639" checksum="1182F0DE9FBB1395" modified="2016-10-05" version="1">MPSIKERALRLERALTSTPDSKNEDSWMKNTSESTERHRTVTQKSYLNKFKHRRVPAINKSASRSNESTKESSNPLQQRMENSSDKDMVNTDRQGSALRLTWQLLCSRRHANSLKEMFWTKQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVE0</accession>
    <name>A0A194XVE0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_712710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078032.1">
        <property type="nucleotide sequence ID" value="XM_018217999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVE0"/>
    <dbReference type="GeneID" id="28827725"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712710"/>
    <dbReference type="InParanoid" id="A0A194XVE0"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF6">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="38715" checksum="F93498346A752704" modified="2016-10-05" version="1">MWKSGLSILIPVMFLMSILSLSMFELKTMTSFNVHHLTEHKPLLDPRDFGLPREGLSVNGIAFGWVPDDKIGSSMSLVNERVGAPGSTMGIYSQVTSADEFDDYQFTEPSRLRDIISSKAVLIATIMPLIPFETFTPALCAQIASSMRKLTDEGVFVWLRFAHEMNWYSRDGDGPALHGGNPNLKNTYTGTPVQFIQMWNILSEAVKDNLMVKMFWSPNSGQDKDQWFPGPAVVDIIGMDFYPKDRSRTPEKVYKPIHDNYALKYNLPFVIGETGVKGSSSSEFKMWWLSGVVDSRLKSALPNYMSCSWFEFDKTDDPEGYDYTIVLKDGALLNRTKSILIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVF8</accession>
    <name>A0A194XVF8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078052.1">
        <property type="nucleotide sequence ID" value="XM_018207781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVF8"/>
    <dbReference type="GeneID" id="28817507"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_473"/>
    <dbReference type="InParanoid" id="A0A194XVF8"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="298" mass="32554" checksum="7F5519158174B1F8" modified="2016-10-05" version="1">MSTFKNIALLGSTGNLGSRILTALNKAGFTVTAIQRKDSTNTPNGPAHSLKVDLSSESELTRAFANQDVVVSALPMPRLATDKIWMNAAIAAGVKRIVPSEFSTNMDNKLSQKLPIIKDKLEIRAYVEWNSVNNGPFMLPQMWLSGWMGPNPKTKTATFHDGGNAIVGTSTLERIGEGVAASLLPENAEKTKNKAVYVYSAAVSERKIADVISKLLGGVTFEETDLSVEQITKDAFAAYEKDQSTHDMRFYIPFCFGKGYGGDYRDIAMNKELGLKEMSDGELEEMFAGTLRKQGLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVV2</accession>
    <name>A0A194XVV2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_693110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078800.1">
        <property type="nucleotide sequence ID" value="XM_018216618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVV2"/>
    <dbReference type="STRING" id="149040.A0A194XVV2"/>
    <dbReference type="GeneID" id="28826344"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693110"/>
    <dbReference type="InParanoid" id="A0A194XVV2"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="306"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="551" mass="60369" checksum="7DC34AACFAD89BA8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWA2</accession>
    <name>A0A194XWA2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_604820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078649.1">
        <property type="nucleotide sequence ID" value="XM_018210370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWA2"/>
    <dbReference type="STRING" id="149040.A0A194XWA2"/>
    <dbReference type="GeneID" id="28820096"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604820"/>
    <dbReference type="InParanoid" id="A0A194XWA2"/>
    <dbReference type="OrthoDB" id="5345504at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="20478" checksum="AD3377C18E6F0204" modified="2016-10-05" version="1" fragment="single">MDRVQATGKIRKRKAETQDNERLSKRLALLNLAERNGEKLYVPVEEPQAQLSPPISTKPKSPAQAPIQLEDDIMQLDNTKHKVYIYDLDAELSDSESSDDGKLVFLPDIEKHLRESRIPPSVLANSEGELAGMNNQLVLYNIPSSLTIPEEQDSVRKAIIETRARARAKHDQKRNEDTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWM3</accession>
    <name>A0A194XWM3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_776627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078886.1">
        <property type="nucleotide sequence ID" value="XM_018222057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWM3"/>
    <dbReference type="STRING" id="149040.A0A194XWM3"/>
    <dbReference type="GeneID" id="28831783"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776627"/>
    <dbReference type="InParanoid" id="A0A194XWM3"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="36015" checksum="85F9AA6B94F161C8" modified="2016-10-05" version="1">MAILSGCPGVEVCVQSVDDGGAQDLQEYDDDGGWTYRKYSHLPEGQRISKYVESKAGAQFRIRIILKNPFRLTSQSVTFKASVDGHGIAQASCTADYFYRASGYYMELITARLDRISGTEITSRPLKFNNLKKVDDTDSTRVRQDSRAVIGIGEIVISVFRTLQRDPILPPPLYRSTVYNPIEEVAEKALKGKAISHGVAYGEQQIVTRHIKETVDVDGYNNPLGVFIFKYRSMEDLKIELIIPRSPSPQPAIAPLNLRGNLPAARRERLANLKREIEEIKAEEEDSQPSGSKRRRTGAAGSSGRAYKTSWTATGQVVVDLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWS0</accession>
    <name>A0A194XWS0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_573068</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078829.1">
        <property type="nucleotide sequence ID" value="XM_018208673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWS0"/>
    <dbReference type="FunCoup" id="A0A194XWS0">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWS0"/>
    <dbReference type="GeneID" id="28818399"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_573068"/>
    <dbReference type="InParanoid" id="A0A194XWS0"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="16">
        <location>
            <begin position="269"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ24474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="555" mass="62317" checksum="BDBC682473C93E31" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWW3</accession>
    <name>A0A194XWW3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_572838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078597.1">
        <property type="nucleotide sequence ID" value="XM_018208661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWW3"/>
    <dbReference type="STRING" id="149040.A0A194XWW3"/>
    <dbReference type="GeneID" id="28818387"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572838"/>
    <dbReference type="InParanoid" id="A0A194XWW3"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ24242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19431" checksum="8652453A994F9C2D" modified="2016-10-05" version="1" fragment="single">EHSYCQECLQTLVSNSLQDEALYPPRCCRKPFEMDLMRPFLSPELISGFHEKGIEFGVADRLYCSNPTCSTFLFPANITGDEIECPLCLVITCTLCKSAAHDGVCPLDTATQKVLALAEGEGWRRCSKCKAVVQLRSGCNHITCRCKAEWCYVCRSAWKSCECPKWNEARIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1V7</accession>
    <name>A0A132B1V7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_633211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060636.1">
        <property type="nucleotide sequence ID" value="XM_018211335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1V7"/>
    <dbReference type="FunCoup" id="A0A132B1V7">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B1V7"/>
    <dbReference type="GeneID" id="28821061"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633211"/>
    <dbReference type="InParanoid" id="A0A132B1V7"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="528"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="924" mass="104176" checksum="CBE49898648949B8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V2</accession>
    <name>A0A132B4V2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_789867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061791.1">
        <property type="nucleotide sequence ID" value="XM_018223305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4V2"/>
    <dbReference type="GeneID" id="28833031"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789867"/>
    <dbReference type="InParanoid" id="A0A132B4V2"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="36704" checksum="4145A4BFFDFC5060" modified="2016-05-11" version="1">MAKRNSQWPWSRRANMFDPPTPLDRFLESPLRALISIIYSVFLFLRGAPFKPPQHKIPVKIICISDTHTNTIPVPNGDVLIHAGDLTNAGTVKDIQSQLDWMASLPHKEKIVIAGNHDSYFDPKSRREEDKGKKLNFRNIHYLEHKAITLKFKGGRKLNFFGAPDIPKCGGSDFAFQYERESAPWENRIPLETDVLITHTPPRYHLDLNLGCAGLLEEIWLVKPRLHVFGHIHSGHGREPVFWDQGQAAYERLMGRSKGGLIKDIFPSMAWWDSLKVLWFGVKGVLWQRLMVGPRGGNGGLLVNAAIVWQSTTDPGNPVEIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B580</accession>
    <name>A0A132B580_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_357804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061923.1">
        <property type="nucleotide sequence ID" value="XM_018206975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B580"/>
    <dbReference type="GeneID" id="28816701"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_357804"/>
    <dbReference type="InParanoid" id="A0A132B580"/>
    <dbReference type="OrthoDB" id="5420711at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="30663" checksum="8BB605CB24D75E0C" modified="2016-05-11" version="1">MADESPFMRIPSEIRLMIYELLFIDNSQRVFQIRNQDPETYKNQPHHQRTGYRIIGRDLVRQSTPTTYTLVNDVELHTSIMRVNRKVYTETAHMLYSNRTFDFGRDIEAIVPFFSDLSKHTRPFIQEISLVKQGSVYSRDYDRCEWSGVCDFMREYMRVESLNLTVEGGRPSLGYAGLPEYSVQDFKTLESVAYEPLEWVWQLLSVKGIKKLEIESEIHHCPPSHSSAMAFFAAFSASIETGFADFLREELIGLQAITRAFQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5Y0</accession>
    <name>A0A132B5Y0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_702428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061649.1">
        <property type="nucleotide sequence ID" value="XM_018217252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5Y0"/>
    <dbReference type="STRING" id="149040.A0A132B5Y0"/>
    <dbReference type="GeneID" id="28826978"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702428"/>
    <dbReference type="InParanoid" id="A0A132B5Y0"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="440" mass="47637" checksum="644E0147DA4EA2D9" modified="2016-05-11" version="1">MTSLFTALPHDADTAALIIPSPQFSATLSHGDLSRLSLKFQQKLANTGISPRHTVALALPNSVEFAVVFLATTFQRASSAPLNPAYTQDEFEFCLQSSNVPLILLPKGAVAENGEAVRAATRCGTAMGEVYYDGSEVNLAIMDFGKTKKRVGVEVETPSESDVAVILHTRESTGQLEAIPLTHQVICSTITQEIATYNLAPTDRCLAIMPLYHIHGLLACFLAPLCASSSLILPSRFSAQDFWSNFTTYSATWYTAIPPIHQAILRSLPNKLPKIRFVRSCSSSLQPNVLKRMELVLNAPILEGNAMSDLSHDAASAPTTSPISPTQKPGCVGKAQGLEMQILDSNDRPLPRGQTGQVCVLGASIVPGYTAISNLPGVTKSGYFKTGDTGYIDEEGYLFLVSTNKKRMSVVANEKTSEKVWDIEMEFGVLHIPKLYCIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B738</accession>
    <name>A0A132B738_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_711897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062049.1">
        <property type="nucleotide sequence ID" value="XM_018217935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B738"/>
    <dbReference type="FunCoup" id="A0A132B738">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="GeneID" id="28827661"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711897"/>
    <dbReference type="InParanoid" id="A0A132B738"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287930" evidence="9">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="58"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="47503" checksum="C79E07C847E904A5" modified="2016-05-11" version="1">MKLYALLALAVAIPASNALVNRAPVPGVVSIPYSRSLSPLQRRNSFVDLSVGATYANYIVNITVGTPAQPITLSLDTGSSDTILLNKESSFCVTNAGYCPSVGYYNANKSSTYKYIASNFSSNFGFSSQGQGSGASGDVATDTFDVAGATLKNQQFDIAYGNATIAFSILGLSYASGENQYPYNNFPLSLAKSGAINLPLFSLWKNAVDSHDGQVLFGGVDTAQYTGSLLTLDTQTRTGFPAPVAFDVLLNGVALSGNSSFPAGSTGSVLHVLDCGTAYSILPNDWVQPIYDQFGVTYFTANDTAYVDCALANSPYTIDFTFGSLTIQVPIKVMVSLRSINPNICTFGIVPAGTRIALLGDNFLSSSYTVFDLSNNQISLAARNFDATTDSIIAVPSGGVKAISTSATGTTPSSTGTTTGTSATSTPTKKSSAPALSLSPATIGVAFIVVLFAFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7U6</accession>
    <name>A0A132B7U6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_711846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217930.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28827656"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711846"/>
    <dbReference type="InParanoid" id="A0A132B7U6"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="43071" checksum="292A640259B8AA82" modified="2016-05-11" version="1">MVSLVPVSITSTQAYSQFEPKCTTPNKTVNYVGSPDTRGTFDLLWSCLLTIVACTWSLQYLNVPEQREDLDPGWKRHIKWSVRTMWPKLKWSFITVIAPEVTLGKAFGNQLADRQVRRGWSQLAAEDGVPGSLLHASYANMGGFWLEIVGQPENTIDLQEFYSSPQGQLPRHFLLSGQDIIQLRIKRIIPRLPSISREEIMERDRGSGESFALSTAGGQILWITIQITARRARGLTVSQLEIAVIAFSACAIATYIANWNRPKQILRPVAIRIEIPVSSFDKKVTEIQAALNEARSQRGRSLFDEIIPSALRGNKELADIPDGYAGLGFLYMGIAGAVLFGGIHLAAWNFHFPTNIELIGWRVASLKDFRKHLGAFLIRRRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7W4</accession>
    <name>A0A132B7W4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_349327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062434.1">
        <property type="nucleotide sequence ID" value="XM_018206909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7W4"/>
    <dbReference type="GeneID" id="28816635"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_349327"/>
    <dbReference type="InParanoid" id="A0A132B7W4"/>
    <dbReference type="OrthoDB" id="3562035at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="435" mass="47251" checksum="932A02965A361EB7" modified="2016-05-11" version="1">MDHRFSTLFFQPPRTPPSPEDTSMSGALPDPNTLGKRKSTTMKQLLKKLFGIPRQTTDPLIKTAEPVPSALSQQVWSEFSSITKTPSKASSTLKKTSTLKKSPRTSGTDSNVVVAPPGQPLPAFKRRDFFHKSSSSSAASISSSVFSSKRTSTAANSVRDSKFSSISSLPSLASLALLPHPSRTSSPGPSLSLSVDELALLQSLIRKIARQLKKQEYLTNHLAGNLVSLFGRKEAQIHSMKRLRVQEREIGAREVWRVKEVVGRGFLRRGVLVGRSEGALNLLRTALDNATRAPSTPQSTVTRRSSSSSPSTLSSASYTTAPSISPRSVPTFTLPLNTLADTTATLSSDLSLHSILNAEFKTTIYTSCLSSRWNGLPGGGFNGNVKGNINDRIMMHRFVSFVESRIQLMEECDVRLVVLVGRVEELGKGRVVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B811</accession>
    <name>A0A132B811_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_701849</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062905.1">
        <property type="nucleotide sequence ID" value="XM_018217220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B811"/>
    <dbReference type="STRING" id="149040.A0A132B811"/>
    <dbReference type="GeneID" id="28826946"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701849"/>
    <dbReference type="InParanoid" id="A0A132B811"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="526"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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            <strain evidence="8 9">CBS 120377</strain>
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    </dbReference>
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        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
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    </dbReference>
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            <end position="52"/>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
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            <strain evidence="5 6">CBS 120377</strain>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08732.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12158" checksum="F3999753427130D1" modified="2016-05-11" version="1">MAVAVAVLLAGTDGTVAASQGSAVSVRLWGQSWVAALAWDPGSWERDGAKPCVVVDCGGAVQCSALEVVLVLVVPGLKLEAPARLKTSSREEEDDLTRHNDVVGVGGGEDDAAATAGDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Y7</accession>
    <name>A0A132B9Y7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_724267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063575.1">
        <property type="nucleotide sequence ID" value="XM_018218881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Y7"/>
    <dbReference type="STRING" id="149040.A0A132B9Y7"/>
    <dbReference type="GeneID" id="28828607"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724267"/>
    <dbReference type="InParanoid" id="A0A132B9Y7"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7162" checksum="2A51E8A8AC7DEECC" modified="2016-05-11" version="1" fragment="single">MSSSQPFQASSPVSPNTTRRKKSRFTYKQFAQLALSSTSSPLRVIAHVDLDAFYAQCEVRLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB06</accession>
    <name>A0A132BB06_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_711471</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063202.1">
        <property type="nucleotide sequence ID" value="XM_018217906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB06"/>
    <dbReference type="FunCoup" id="A0A132BB06">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BB06"/>
    <dbReference type="GeneID" id="28827632"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711471"/>
    <dbReference type="InParanoid" id="A0A132BB06"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ08847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="346" mass="38274" checksum="12B64A115E5EB9E8" modified="2016-05-11" version="1">MFARQAFRAAQPLKTQTRRYATEPSTGGSNTLLYAGIAAALAGGGYYFYNQGDNAAKVKGAAKDAEAKAKQDVGAAKGKVEGAVGKSAFTGGDQGFISLKLESVENINHNTKKFRFALPEEDQVSGLKVASALLTKFKGPEMEKPAIRPYTPVNDEDEQGYLDLLVKKYPNGAMSSHMHDMEPGQRLDFKGPIPKYPWETNKHKHIALIAGGTGITPMYQVARAIFNNPEDKTKVTLIFANVTEEDILLKKEWEHLENTYPQRFRAFYVLDKPPKEWKGNSGYITKELLKTVLPEPKEENIKVFVCGPPPMYKAISGVKKSPSDQGELDGSILEQLGYSKDQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBW5</accession>
    <name>A0A132BBW5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LY89DRAFT_701473</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063854.1">
        <property type="nucleotide sequence ID" value="XM_018217200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBW5"/>
    <dbReference type="STRING" id="149040.A0A132BBW5"/>
    <dbReference type="GeneID" id="28826926"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701473"/>
    <dbReference type="InParanoid" id="A0A132BBW5"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KUJ09499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="668" mass="72318" checksum="7FBC2789F910067D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD61</accession>
    <name>A0A132BD61_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_710818</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064284.1">
        <property type="nucleotide sequence ID" value="XM_018217862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD61"/>
    <dbReference type="FunCoup" id="A0A132BD61">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BD61"/>
    <dbReference type="GeneID" id="28827588"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710818"/>
    <dbReference type="InParanoid" id="A0A132BD61"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="700"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ09929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1142" mass="129388" checksum="E6A6E5AFB59E1955" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDE5</accession>
    <name>A0A132BDE5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_656229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064807.1">
        <property type="nucleotide sequence ID" value="XM_018212372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDE5"/>
    <dbReference type="GeneID" id="28822098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656229"/>
    <dbReference type="InParanoid" id="A0A132BDE5"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="314" mass="34529" checksum="230BD1248B477A79" modified="2016-05-11" version="1">MVDLSAEEFSPEYLTEYRGTAPMVIAVTFITLEILFTALRYWTRYQGHIKWGADDYLMIPACILCLSICAVVIVSLKHTGVGHHMAALDPQQILLLTKFQLILPPVYFAAVLFPKLAIIALYLRIFLDDLQRMATWTIAGILTDVAMLLLPLPVVWSLHGSRTLQVGIAITFATASVGLIGAILRFVGFFNQNEANDFSWDAAPLMVWAVVETGAYLIAACLPSLRPLIVSVRKRTPFSQSISRMEEVATTGGGEGGILSHERHRSDFEYSVNKLDEQIGQIGAQCTSKAETGVRLDSNEITVSVEHQSQVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDL2</accession>
    <name>A0A132BDL2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_711048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064112.1">
        <property type="nucleotide sequence ID" value="XM_018217879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDL2"/>
    <dbReference type="FunCoup" id="A0A132BDL2">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BDL2"/>
    <dbReference type="GeneID" id="28827605"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711048"/>
    <dbReference type="InParanoid" id="A0A132BDL2"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288161" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="20"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="743"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ09757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="976" mass="105251" checksum="D70B33CA8CBD4FC6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE31</accession>
    <name>A0A132BE31_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_700787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064614.1">
        <property type="nucleotide sequence ID" value="XM_018217146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE31"/>
    <dbReference type="STRING" id="149040.A0A132BE31"/>
    <dbReference type="GeneID" id="28826872"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700787"/>
    <dbReference type="InParanoid" id="A0A132BE31"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="350"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065187.1">
        <property type="nucleotide sequence ID" value="XM_018220510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT90"/>
    <dbReference type="STRING" id="149040.A0A194WT90"/>
    <dbReference type="GeneID" id="28830236"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739818"/>
    <dbReference type="InParanoid" id="A0A194WT90"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="34092" checksum="BBA3C8DEE3653351" modified="2016-10-05" version="1">MSMQSHLQDIGLVQYAQDCGFETWRDLVCITESDLEQIGMLRGHRRKLQRVLNLFSVKENGPLLVTSTSEQQYQKRRYRRHPKRDSNAPARPKTAYQLFAREVRRQMQDDNMTFVELAKLVGARWAILSPDERNTFLSASKAKLRFQDQLRLYTGTEEHLRYQQYLQGFKNQHDSSGQAQQSSEARNSHMNEQPSEPTRDDAILGSQTTPLQRQQGQTTGGATDGHTLVGSGERTLAKVDRYEEMKSSSPVSCLFQANCANPNHAVPIEGHGENQIRDCASTSTTRLDNSQYFRTVLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTC6</accession>
    <name>A0A194WTC6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_700738</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065284.1">
        <property type="nucleotide sequence ID" value="XM_018217142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTC6"/>
    <dbReference type="STRING" id="149040.A0A194WTC6"/>
    <dbReference type="GeneID" id="28826868"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700738"/>
    <dbReference type="InParanoid" id="A0A194WTC6"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267422" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="44422" checksum="5CB4B2AB731C99D4" modified="2016-10-05" version="1">MLLTLLTSLTLLLGSALGVVTQVGTACTVTPLSSDSSASGTIDDTSQILAAFKSCGKDGSISFSDGIYHINQVMDITLTNCDVVLRGTWIWSTDIQYWLSHSISVVYAGRSTAWRIGGDNFSIRGEGVVFDGNGQKWYDQNKNQGNQNGRPISFTLWNAKNALVDGITWRQVQFWHTFIAHSQNITMTNLDMNATSNSQYKTVNTDGTDTWNSKDIVISNWTVTCGDDCISIKGNSSNVHVSNVVCHESGGMCVGSIGKDAGTPDFVDDIVFDNITLIHSSNAAWIKTYPSGGGHVRNVLFKNIQFTDVNQPIYISPCIYSYSNCDASRLQISDVRWENISGTARYNVGAGIHCSAAAVCQNLTFENIDIKQKSGAAVEYLCSNIANQKTSGLACTGSCPGNQPQQLNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTJ8</accession>
    <name>A0A194WTJ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_786901</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065641.1">
        <property type="nucleotide sequence ID" value="XM_018223026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTJ8"/>
    <dbReference type="STRING" id="149040.A0A194WTJ8"/>
    <dbReference type="GeneID" id="28832752"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786901"/>
    <dbReference type="InParanoid" id="A0A194WTJ8"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="250"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="50592" checksum="ACA4ADBAEF942923" modified="2016-10-05" version="1">MTRGEILHLHIGQAGTQLGNSAWELYLLEHGLKQDGRPDPDAKALHDSGELDTVFTETGSGKYVPRSIFVDLDPSPIDEIRTGDYRQLFHPELLISGKEDAANNYARGHYTIGKEILDGTLDKIRRVLDNCSSLQGFLIFHSFGGGTGSGFGSLLLERLSTDYGKKSKLEFAVYPAPRVSTAVVEPYNAVLSTHSTIENSDCTFLVDNEAVYDICRRNLDIPRPSFEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVISAAKSSHESFKTQDLTLQCFEPNNQMVVCDPRNGKYMAVALLYRGDVVPRDCNAAVASLKAKTSFNLVEWCPTGFKLGINYQKPMSVPSTSPNDGALASVDRSVSMLSNTTAIAEAWSRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVAADSFEPGEGEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUS4</accession>
    <name>A0A194WUS4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_594114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066073.1">
        <property type="nucleotide sequence ID" value="XM_018209784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUS4"/>
    <dbReference type="STRING" id="149040.A0A194WUS4"/>
    <dbReference type="GeneID" id="28819510"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594114"/>
    <dbReference type="InParanoid" id="A0A194WUS4"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="44455" checksum="CFFC03E26E821B94" modified="2016-10-05" version="1">MARSPQETPFLPRTFDENDPNRSVSRIASHLFTNWNPGHGHLEVVPLPSTSHKQLYQLTYRRHIAFDQRTHHETALVKVHKLPLSNSQKQVFNIHKVLALHSLASPLLLTFLNGYAYGFVHGHACSSSIMSKESIWRAIAWEMAHWHVILPVSDAESGREVPDVWSKAREWLDILSAEGEKAKLEKEFEFLIERLRGRNTNKEQFVFGHGNLRPENIVWKGTHDEYSDEYQIDAIKFIDYEHCTYCPVAFELATYFSTWAGSECDYELLPAEKTRRAFIREYVDACALYSNSDSEDEIEVEGQEDAVEKLVQEVDEWRGFVGFYWGLFALLKATDTEVDSAIRHEHAKYSKLKFAEYYAWKEDDVTIAREGGQVHVVERERMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUX8</accession>
    <name>A0A194WUX8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_539235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065824.1">
        <property type="nucleotide sequence ID" value="XM_018208143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUX8"/>
    <dbReference type="FunCoup" id="A0A194WUX8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="28817869"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_539235"/>
    <dbReference type="InParanoid" id="A0A194WUX8"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="29002" checksum="F3180D5B4902BFC7" modified="2016-10-05" version="1" fragment="single">ISPSWLPNFSTGINPIQCHSHNDYAQKIPLYQSLAVGCVSTEVDIFVRGKDLLVGHDGGRLNSAWTLRSLYLDPLKAILEGQNGNSENVAAGVVKGIFDETPQTSFILLVDFKDSAGKTWNLFLSQLDDFRQKDWLTYWKPETGVVQRPITVVVTGASLLNDVIANTTYRDVFFDAPLGDLANSNGKYDNTNSYYASTAMGRAVGGVGQQFSAGQNSVIVAQVQQATALGLKTRYWDAPGSPEVLRNKVWENLVGLGVSVLNVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVB3</accession>
    <name>A0A194WVB3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_226921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065887.1">
        <property type="nucleotide sequence ID" value="XM_018206001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVB3"/>
    <dbReference type="GeneID" id="28815727"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_226921"/>
    <dbReference type="InParanoid" id="A0A194WVB3"/>
    <dbReference type="OrthoDB" id="3558158at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="140" mass="15298" checksum="347602E1A75B3A3F" modified="2016-10-05" version="1">MGGGPENPMKMEMDGVVTPLNERVTTLTINDDQATAMSVGDNKEGVLDGADTDSEIDVMDVVEHKQELMRELKALGVKPLLKPDYTKPLDEPSWGDEDDEEEDDDVDMEGEGEGVLDGEDEEEGDEGLEDGELEELRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVD3</accession>
    <name>A0A194WVD3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_536401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066281.1">
        <property type="nucleotide sequence ID" value="XM_018208103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVD3"/>
    <dbReference type="GeneID" id="28817829"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_536401"/>
    <dbReference type="InParanoid" id="A0A194WVD3"/>
    <dbReference type="OrthoDB" id="3491583at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="50" mass="5429" checksum="DE69F418C261DBFC" modified="2016-10-05" version="1" fragment="single">MPVAAVAKAERATYHSHTAVFDLRDDCKMARLKVPGFAPVISTGDPAFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVL8</accession>
    <name>A0A194WVL8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_738639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066368.1">
        <property type="nucleotide sequence ID" value="XM_018220393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVL8"/>
    <dbReference type="GeneID" id="28830119"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738639"/>
    <dbReference type="InParanoid" id="A0A194WVL8"/>
    <dbReference type="OrthoDB" id="3564997at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="201" mass="22754" checksum="E93C6A0572CF5751" modified="2016-10-05" version="1">MCVETIQTFTTCHCTIHRHNICESHISLTHRQLTTTPCPSLTTRYVQTTPTTSLTHGPLGCASPTHCPGTTQELYHFDNGQAKRKERIVAFAELRGVDERARCWDGRLREGWRHGCGMGRGWDGGREGGSWRHLSGVDLQVGKRAVAKDVKGKREEDEDEYDEEWSEYGRKENVKVPKIKVEEVDDGSELARVLEDVDMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWS0</accession>
    <name>A0A194WWS0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_722023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066745.1">
        <property type="nucleotide sequence ID" value="XM_018218696.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWS0"/>
    <dbReference type="GeneID" id="28828422"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722023"/>
    <dbReference type="InParanoid" id="A0A194WWS0"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="426"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1833"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="426"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="581"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1923" mass="213758" checksum="CBA9C9D7F3282EB3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWV9</accession>
    <name>A0A194WWV9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_700035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066427.1">
        <property type="nucleotide sequence ID" value="XM_018217096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWV9"/>
    <dbReference type="STRING" id="149040.A0A194WWV9"/>
    <dbReference type="GeneID" id="28826822"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700035"/>
    <dbReference type="InParanoid" id="A0A194WWV9"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="717" mass="78270" checksum="111080AB0C19EECA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXK9</accession>
    <name>A0A194WXK9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_205464</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066677.1">
        <property type="nucleotide sequence ID" value="XM_018205818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXK9"/>
    <dbReference type="STRING" id="149040.A0A194WXK9"/>
    <dbReference type="GeneID" id="28815544"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_205464"/>
    <dbReference type="InParanoid" id="A0A194WXK9"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267565" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="24140" checksum="EC4BFA1F811A4E3D" modified="2016-10-05" version="1">MKFVTPFLALATAVHAHYNFPSMISGTTTTPAWQFVRQWTGYYTFDPVQNVASEDIRCNVNGSTAFAPNTLSLAAGSTVGFSANPDIYHPGPLLVYMAKVPAGKTAANFDGSGAVWFKIYEEGPTFGGQALTWPTDSATSVSFKIPAATPSGDYLLRVEHIGLHVAQSSGGAQFYLSCGQITVTGGGSGTPGPLVSFPGAYKATDPGILINVYYPVPTSYTPPGPAVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXV6</accession>
    <name>A0A194WXV6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066782.1">
        <property type="nucleotide sequence ID" value="XM_018218699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXV6"/>
    <dbReference type="STRING" id="149040.A0A194WXV6"/>
    <dbReference type="GeneID" id="28828425"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722052"/>
    <dbReference type="InParanoid" id="A0A194WXV6"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23403" checksum="D73A2799ABD5C45E" modified="2016-10-05" version="1">MPYIFPQPLPFLDPTPQTMLLNKRLTTFLSQNTTPQLPTLLLLSPTGKLLTSSSPLPASTLRTQATLACSLWTLYQPSLPSLISTSLPSRHHPDPSPRGSDSTISSAATATESELSAITIQLTHGVMVIRQLACGLLFVAIGAPLSPSAQPASPPSSPPAGNAEEYTEGGSLVGVGSAAASEAGSVRSVGGSRTGIMGIRRRADEVGRWLDGQLEGFTLSSGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYB8</accession>
    <name>A0A194WYB8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_721757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067285.1">
        <property type="nucleotide sequence ID" value="XM_018218671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYB8"/>
    <dbReference type="GeneID" id="28828397"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721757"/>
    <dbReference type="InParanoid" id="A0A194WYB8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="19482" checksum="55F6F83BEE6A24F3" modified="2016-10-05" version="1">MQPLDHPEPTPAPSSPRNLFSSFRTHLNVPIPLFGSRSAPSQAHTGKQTQLYDLEAQRFDIPRRGSGVIIPTVKTSIRSGPAPFVLPHATSVPAAIHEEEDEDIDPLAPKMGTRAYREREKREMQRRKDEEKVAKVIADDVKVEMGGGSVGKGKEFASVIKIVKSFDLSEESKAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X008</accession>
    <name>A0A194X008_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_754342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067886.1">
        <property type="nucleotide sequence ID" value="XM_018221319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X008"/>
    <dbReference type="GeneID" id="28831045"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754342"/>
    <dbReference type="InParanoid" id="A0A194X008"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24250" checksum="7A326EE0828A8690" modified="2016-10-05" version="1">MASANPPPDDPPLGNYGYDEKAVARGLSKRRQSEWLERSKKWPDLPARRWAARKVIGKGAYGICGQWDYTGNDKSMPRQIVVKQSIGSTAKILRGESKMMHLTTSTGADYVVKLYKGCHRGAGTGTSDIDPLPYNSLGMYIPHQEVVRMYMEYAPGGDLDAFFKRLIATPGARVIPEEHLWRLLHCLAKASMALGRFSLLLQTFQGHGKSWKCNFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0P4</accession>
    <name>A0A194X0P4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_621421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068126.1">
        <property type="nucleotide sequence ID" value="XM_018210948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0P4"/>
    <dbReference type="STRING" id="149040.A0A194X0P4"/>
    <dbReference type="GeneID" id="28820674"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_621421"/>
    <dbReference type="InParanoid" id="A0A194X0P4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="496" mass="55515" checksum="9D1729E508CBD595" modified="2016-10-05" version="1">MFSLYAVGTLFGSAYLVYQYIIFPLFLSPLSKIPPAHWSVPSSARWINSHRLNGKTGLSATLSAHNRLGPIVRLSPDEISVASIDGLRKIYSGGFEKDESYVQEFTNYGTVNLVSMLGNREHGMQKRMISHVYSKSYIQNSGDGKRAWEILVGRLLEVLYKAEGAAFDAYGLNQGIGADFMSAYLFGLENATDFMRDTETRTRISQCYRKKFKRLPGEAGATETVESFVLDLCRAAARTTERDIDSETGTSPVVYAQLSSQMSKRFSTPSPENKELLVASEMFDQFTASIETSRISLTYMEWELSRRPSLQQSLRQELLTLSPPIQVGESQLPDPKSIDSLPLLNAILKETLRLYTPSPATLTRITPPVGTTIEGYFIPGNIVIGTSGGCMHQNSSVFPEPQEFKPERWLTEDEEKRKEMNRWFWAFGSGGRMCIGSHYAIHMLKLSIAAIYSNFETEIVDDEGIEQEDAFLAGPVGEKLVLRFRALASRSDQEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0X2</accession>
    <name>A0A194X0X2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_736831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068190.1">
        <property type="nucleotide sequence ID" value="XM_018220177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0X2"/>
    <dbReference type="GeneID" id="28829903"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736831"/>
    <dbReference type="InParanoid" id="A0A194X0X2"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF11">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN_GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267692" evidence="4">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="31912" checksum="F7C62C1847C35D62" modified="2016-10-05" version="1">MRLLAPVLFGAAMVQAKSSAPKNTVLCGQYDTHWSANQSYTFNTNEWGDDGSGAQCISVNNATTDFNATWSWSDNPTLVHSFPNIKLQSDLLPIELSNLSHLNISASWSMNPSSSSVENLDTIDAAANVVVDMFLDTDPTTANSTTLPKYEVMIWIAAYGGKKPIGFSSSIKNPPTHSLNGTIYTLYSGANNNGQFVYSWLAPSNVTTFDRDISPLLHYLWQHKLISESNYLGVVQFGTETFHASSNVTFSAQDFNISVAAGQPLVDSRAAGGALPNLVLLLLPLAFFFTFTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X112</accession>
    <name>A0A194X112_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-kumamolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_698854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068014.1">
        <property type="nucleotide sequence ID" value="XM_018217011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X112"/>
    <dbReference type="STRING" id="149040.A0A194X112"/>
    <dbReference type="GeneID" id="28826737"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698854"/>
    <dbReference type="InParanoid" id="A0A194X112"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S53" evidence="3">
        <location>
            <begin position="44"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="445" mass="47200" checksum="CDA21323D2F81FA2" modified="2016-10-05" version="1">MRELNKRALERRGGILGSANDQSNPKQGPQVLNALMTLENCDTMITPPCLQALYNAPPGSMSMKNNTLGVVEYTPQAFLQSDLDMYFKQFEPRLDGVSPNTNLIDGASIQTKNQSFSFNGESALDLEFAMTLIFPQQVTLYQVGDLVNGGSFNNFLDAIDGSYCTFEGGDSKDPSVDGQYPDSLPGGFTGAQNCGGFASTNVISTSYGSNEADLTAKYEQRQCLEYMKLGLQGVSILYSSGDFGVAGNGGQCIDPVTGAYNNGTNGLFNPSFPGTCPYVTSVGATQIVNGSTVRTPESASERVIFSGGGFSNVFAMPSYQQKAQATYFAEHAPAFGADRFNNSQKVRGYPDVSANGVNYVTAVDGKFSLAFGTSASTPTFASLLNMINEQRLNAKKASIGFVNPVLYANPQVLNDVTNGGNQGCGTAGFNSTVGWDPVTGFCISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X124</accession>
    <name>A0A194X124_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_590540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068250.1">
        <property type="nucleotide sequence ID" value="XM_018209600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X124"/>
    <dbReference type="STRING" id="149040.A0A194X124"/>
    <dbReference type="GeneID" id="28819326"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590540"/>
    <dbReference type="InParanoid" id="A0A194X124"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="44132" checksum="55CD75C8F7EB05CD" modified="2016-10-05" version="1">MSSGGISTYEQRQKWRAEHLQTNDPFVVDIPKIELHVHIEGTMTPELRWKLSQKNKIPLTCGADKIALTSLEETQKAYTCIRGRIGAASAEASKSFTFFQIYYEGFDLLQSEEDYYDLAMRYFERAAKLNVRYCEPFFDPQGHTRRGISMEVIMKGFQKAQIEAERELNVKSQWIMCFLRDMSPESATEQYEAALPYKDMIVGIGLDSDELDRPPKLFDEVFRRAREDGFRRTSHCDFNQKDTHEHIRQVAESLGGPGTERIDHGLNAADQDDLMNMIKEKGIGMTICPCAYIRHAPESEVFVRIRKLFDAGIKITIASDDPAYMEDNWVLHNLYMVRDKCKFTDQEMVRLQRNAIEICWASDDEKAALSQEIDFFEKAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1X0</accession>
    <name>A0A194X1X0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_148209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068192.1">
        <property type="nucleotide sequence ID" value="XM_018205375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1X0"/>
    <dbReference type="STRING" id="149040.A0A194X1X0"/>
    <dbReference type="GeneID" id="28815101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_148209"/>
    <dbReference type="InParanoid" id="A0A194X1X0"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="344"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ13837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="600" mass="65447" checksum="AC11305A0045FBA8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X237</accession>
    <name>A0A194X237_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_590649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068262.1">
        <property type="nucleotide sequence ID" value="XM_018209603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X237"/>
    <dbReference type="GeneID" id="28819329"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590649"/>
    <dbReference type="InParanoid" id="A0A194X237"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF74">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="482" mass="52455" checksum="F58DEF8E00044859" modified="2016-10-05" version="1">MSKGEEEVIDYATEKKLVRKLDFWIVPLMMVTYTLQSYDKGIMSAATQFGFNTDLGLTRVIGHEADGTAITNNQKYSNASMIFYIGYLCGTYPMMYLTQRFSTSRVLSIATFFWGAVVLSTAGCYNYAGIMVNRFFLGFLESAVAPAFTVLVTFWWTREEQALRTGLWYSCVGVATTISPLINYGLGQIHSSLASWKPIFLILGAVTVLWSSVLFFCLPDSPLTTKGLTEPERAIAIRRLERNNAGTISHTFNKAQFLEAFRDYKLYSCTLIILLTGVPSGAIGTFGTVVINGFGFSHFDSLALTCPIGAITALSILLGGYVTRKVNNVRYFVIITFALISIAGAAICWGGPRSDRGLLFAGIFLMAVQVAAGGLAVSLAASNVAGHTKKATISATTFIGYCVGNVIGPEIFGASPGPVYHAGFVGSCICLCLVVVIAAITYFLLRRDNAKRDRMTGGARLGIHSIDEDLSDMQNEDFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X239</accession>
    <name>A0A194X239_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_784862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068419.1">
        <property type="nucleotide sequence ID" value="XM_018222828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X239"/>
    <dbReference type="GeneID" id="28832554"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784862"/>
    <dbReference type="InParanoid" id="A0A194X239"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="202"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="681" mass="78517" checksum="28DBAE763673AD86" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2E9</accession>
    <name>A0A194X2E9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_590243</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068730.1">
        <property type="nucleotide sequence ID" value="XM_018209580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2E9"/>
    <dbReference type="FunCoup" id="A0A194X2E9">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="GeneID" id="28819306"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590243"/>
    <dbReference type="InParanoid" id="A0A194X2E9"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="36404" checksum="E0206121AF8EC9D8" modified="2016-10-05" version="1">MMEKRTNDALNANPDVFLYPATSQINITTHGSDWYWAVTAVMVVSTFAFIGMSFTVPRRNRIFHYITAGITLVASIAYFTMASNLGYAAIPVEFIRSNPKVAGMNGMNYREIFYVRYIDWFVTTPLLLMDLLLTAGLPWPTVLYTILMDWIMVVTGLVGALVASSYKWGYFTFAMFALFFIAYNVCYVGLAHAKAIGPNVHRTFLMCGVWTIFLWFLYPIAWGLAEGGNVISPDSEAVFYGVLDIMAKPVFGAMLLFGHRNIDPAVLGLHIRDYEDPTATRRTEKSSALGASDNGVVDSHHHNGTNTAVAGDNVTTGAPTSTGTHPQTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2F4</accession>
    <name>A0A194X2F4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_620807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068735.1">
        <property type="nucleotide sequence ID" value="XM_018210924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2F4"/>
    <dbReference type="STRING" id="149040.A0A194X2F4"/>
    <dbReference type="GeneID" id="28820650"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620807"/>
    <dbReference type="InParanoid" id="A0A194X2F4"/>
    <dbReference type="OrthoDB" id="5379086at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="432" mass="48013" checksum="F2731B3B72A1B9CE" modified="2016-10-05" version="1">MAESEPDLTFLNELYGEIERNPPALEARKLLTQHCYHSGWTDAARENLQQLRALDPSALEEEPWTRDLLQKSSSKATDKSASESGPSPVQVAAQKLEMVEGYQSLRLRAKKMLQETRLLQNFVSSPAGSTNPELRARFEAHDPDLNALVNGRVSSVLKVQQPGSARGIARQMEKDPEKAVDVAASDLEDVARWLRSHVTRTTAGDNDAIREALVKRAQALSAALPDALKKHPSTAMMHIEHEVLKRKYHSEETMYGDLVSDIPRAQFLVTDDGYGWDMEELAQAIKSNGGIMRNPLSKQMFSPDDVRAIIQHPLGQDLAALQIEQSKLSLGIREKTVDELDKMAKVFLADMSEDQLKSREVLETFIAYLATLPVTEQEALDKLRVPAVDSHTGMAFDTSIGEAVRDAQGNKLCFHKCADLLTQAVSHLKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2H0</accession>
    <name>A0A194X2H0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_137598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068746.1">
        <property type="nucleotide sequence ID" value="XM_018205288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2H0"/>
    <dbReference type="STRING" id="149040.A0A194X2H0"/>
    <dbReference type="GeneID" id="28815014"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_137598"/>
    <dbReference type="InParanoid" id="A0A194X2H0"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29908" checksum="8572D37914614EF6" modified="2016-10-05" version="1">MSSRIPPLLEPYLALPPEASLVLLTSVLGASTNWLVLRFLHSALSEVSSGVSPEDEPKVLLVSFMLDLAFWRENARRLGLDLDKLAAKKRFVFVDGLSGLFLSKQQKASPAKGGNVTLSNSGLESVSEAIHNDAKTLRHSQGTTKIMLIVDQLDLLLAAGGDAVNAVGLGDLLLGLREEVHCTIVSLSADLPLVSNPQTPLEANHAAFLISTAHQADFTMSLRLLDTGTARDVSGVVRVTVGDRATEEDEDIQRKIEEKELLYFVGGDGGVKVFERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2N2</accession>
    <name>A0A194X2N2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_736324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068634.1">
        <property type="nucleotide sequence ID" value="XM_018220111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2N2"/>
    <dbReference type="GeneID" id="28829837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736324"/>
    <dbReference type="InParanoid" id="A0A194X2N2"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="358" mass="38580" checksum="70AFCEBF5745F4CD" modified="2016-10-05" version="1">MADSVAHTGSRDSDKKFEAGEKYQAEQIEEQRNYAGARPTTGQKVKRHCGRFWWLHLLIFCIVFLIIALCLVYVAMPKIAQHGVNESSIEFTDIQFLSPTSDSIVITQKAILHSPSMYTPTLDPFNASLYLVTNGTFAASPMIILPMPRIHALHPQSNASIDNQNTTIVDLDQVTEYATTVLTNETVTTALTGRTKLHEGKLPVNWVNYNSSTTYLGLNGLKGFNVTGVTLNLSAPSGQPNLQGFAFIPNPSVLTVAMGNVTLSLSTEKAGVVGISTVPDMTIRPGNNSLPMTAVLNQTAIVSSLDTSGKVNVTITGTSSVYNGEHLSYYEKALASNVLVLEMNVLQILSDSAAAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3V6</accession>
    <name>A0A194X3V6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lecithin:cholesterol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_686481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069206.1">
        <property type="nucleotide sequence ID" value="XM_018215294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3V6"/>
    <dbReference type="FunCoup" id="A0A194X3V6">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3V6"/>
    <dbReference type="GeneID" id="28825020"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686481"/>
    <dbReference type="InParanoid" id="A0A194X3V6"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="60732" checksum="CC2E362FCCCA3C92" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3X4</accession>
    <name>A0A194X3X4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_698460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069221.1">
        <property type="nucleotide sequence ID" value="XM_018216981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3X4"/>
    <dbReference type="FunCoup" id="A0A194X3X4">
        <property type="interactions" value="1274"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3X4"/>
    <dbReference type="GeneID" id="28826707"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698460"/>
    <dbReference type="InParanoid" id="A0A194X3X4"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="30768" checksum="59308F9C8821C3DD" modified="2016-10-05" version="1">MSERDLQDILRKLKSSRDYADCSSLLSKAKITLLKLKALTPQPNTPSSTLQLAREVFETGALLSIRAKDPAAFTRYVHQLTPFYELPPERLSPAHSEKNKITGLYLLLLLTQSDYAGFHTELEGLELRQGREGMLEKDKYLGYPIKLERWLMEGSYDLVWKAMASREVPSEEYGVFSEILINQIRHEIATCSQTAYPSLPISSTKNLLFLDSEGAVIEFAHTRGWLIKDGRIYFPQQSMKATVDEEGNTKELSQMAIENTLGYARELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X407</accession>
    <name>A0A194X407_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_124885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X407"/>
    <dbReference type="GeneID" id="28814914"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_124885"/>
    <dbReference type="InParanoid" id="A0A194X407"/>
    <dbReference type="OrthoDB" id="5398779at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF3">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="18199" checksum="51FD87A3847D1B86" modified="2016-10-05" version="1">MDSTGNVKIEIIKMREQIDYTAISHVCAGGLGNFQDNCLPHCQLQAIHEDGCNTMALAYDNYYKNQRLIHPPKRYYDILMRPREPHDKGWFSFQSITTTCYYWLDTLCIPIHHIQEKHRAINSMGRVYGGAANTLVLDPALSRIRYNELGNEWESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X419</accession>
    <name>A0A194X419_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_671330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069288.1">
        <property type="nucleotide sequence ID" value="XM_018213212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X419"/>
    <dbReference type="GeneID" id="28822938"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671330"/>
    <dbReference type="InParanoid" id="A0A194X419"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267829" evidence="2">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="166" mass="16226" checksum="A1587FD9F543083E" modified="2016-10-05" version="1">MKSSTILAILSFALTAYAAATKASSNDANFVNPDASDGSAGEAAAALAQSAVDAFNAGDIITAVGYSSLSSVLQSLTTPREQAPAATAAANAKANKAGRRAENKANADATFVNPDASDGSAGEAAAALAQSAVDSFNAGDIITGTAEPAATAAAKKNGKAARYVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X542</accession>
    <name>A0A194X542_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_735421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069653.1">
        <property type="nucleotide sequence ID" value="XM_018220011.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X542">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X542"/>
    <dbReference type="GeneID" id="28829737"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735421"/>
    <dbReference type="InParanoid" id="A0A194X542"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="378"/>
            <end position="505"/>
        </location>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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        </source>
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</entry>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44164" checksum="AD8B7CEB308B962F" modified="2016-10-05" version="1">MPENSVGTMDGQDDTTRSTNKPRGRPRKDIIDTGIELRRAKTRRAQTTFRARQRQHLNKLEQKCRRLEDVVEQMTTAVLDFSDDLDQSNNLDPNAGENLRTAMTKFVALSKTGSGDPNELQQDPRIFAKIDRRTFKQPSTEAKRAAITAMPTPPTNRPSKADLRMNHNIWNRHTESSNSASSAIPYILAGRDSFASRLYYETIALVLRSMYGELPGAIAGRMFRFKSRYCTCAKIRGILGSVFNMLLHGTFQSEDVNTDITDDKAVKALIVHQIESSGGSEHDYLSTWEVERYLKKKWRLGIDSNTVKVQASALLSINNKTSQHAAVSDGSPKLVFPTMVPGFPETSPSMWNVESLLERLKLTSVSIGEGPRWHIADIDAAVEAFLTESKEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X720</accession>
    <name>A0A194X720_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_587692</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070325.1">
        <property type="nucleotide sequence ID" value="XM_018209443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X720"/>
    <dbReference type="FunCoup" id="A0A194X720">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X720"/>
    <dbReference type="GeneID" id="28819169"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587692"/>
    <dbReference type="InParanoid" id="A0A194X720"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="461"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="487"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="510"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ15970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="58755" checksum="17A2C59F27E760C9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7J1</accession>
    <name>A0A194X7J1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070493.1">
        <property type="nucleotide sequence ID" value="XM_018215034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7J1"/>
    <dbReference type="FunCoup" id="A0A194X7J1">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7J1"/>
    <dbReference type="GeneID" id="28824760"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685182"/>
    <dbReference type="InParanoid" id="A0A194X7J1"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="29528" checksum="ED3DD960ECEA33F3" modified="2016-10-05" version="1">MAASTLPAMKTNPKYIFFTDFDGTITQQDSNDFMTDTLGYGEKLRKQGNKDVLDGKMTFRDSFREMLDSVKTPFDQCIKILCENIKLDPYFKEFFDYARQNGIPIVVLSGGMTPIVRGLLVHLLGEDAHEMQIVSNDVAPRDGKSINEEGGWQIAYHDDTGFGHDKSLEIRPYANLPENERPVMFYAGDGVSDFSAAKETDLLFAKKGRDLITYCIRGGMPFTIFEDWSSILATVKDIVDGKTTVKEVSAAGVKEAKADGMANGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7L8</accession>
    <name>A0A194X7L8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_685200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070516.1">
        <property type="nucleotide sequence ID" value="XM_018215038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7L8"/>
    <dbReference type="GeneID" id="28824764"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685200"/>
    <dbReference type="InParanoid" id="A0A194X7L8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="126" mass="13934" checksum="D5B51855B0B90FA0" modified="2016-10-05" version="1">MAVKNSVILKKSIIGGVDLTKSQGFIELSVLHNKIEFIDILLEAGVPIHEKHQEGFSLVTTTFRKNRGDILTHRLSKGADPNAIGDGLSLANAARFTDQRRLRFVLDAGAFVNKQIKRRSALVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7N1</accession>
    <name>A0A194X7N1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_718947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070530.1">
        <property type="nucleotide sequence ID" value="XM_018218456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7N1"/>
    <dbReference type="FunCoup" id="A0A194X7N1">
        <property type="interactions" value="1229"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7N1"/>
    <dbReference type="GeneID" id="28828182"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718947"/>
    <dbReference type="InParanoid" id="A0A194X7N1"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="962" mass="107953" checksum="65380EE881EF68D2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9J1</accession>
    <name>A0A194X9J1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative UDP-glucuronosyltransferase 2A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_697142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071149.1">
        <property type="nucleotide sequence ID" value="XM_018216878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9J1"/>
    <dbReference type="GeneID" id="28826604"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697142"/>
    <dbReference type="InParanoid" id="A0A194X9J1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000072">
        <property type="entry name" value="Glycosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="313"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="49043" checksum="2BF69DF10AF96610" modified="2016-10-05" version="1">MDPTKPLVIIGCTPVYGHLMPIRAMAKLLVQRGYEVTFVSCSHYQKLVEEVGCHYVAIEGYGDWYEAELNTRFAERNTLPPGPVQLSYDIEHCFVRPIPTQHEAMQKAIKMNMERHPGRPIVQLSESVFQGSLPVNLGAGIKPTATMGIGVIPMSLSSCDTAPFGPGLPPDSSLEGRAKYAAMSKQIAELFFGKPERVWKEMFVEVGATIPELPMFDAPFYLQDRFLQMCTPSAEYPRSDAPDTIRFTGGLPKGSRDPMTEFPSFWKEITAGDKDIVFICQGTIALNYSDLIIPAMAALKDRPNTIVVVALGIKGEKFPEGTFVPENARVADYIPFDELLPRCSVFLTNGGYGAFQHAIANGVPIICGGAGEDKPEVCARVEWSGMGINLKTGQPTQEQISEAVDQIIKNPKYRKRAKEMEAEMASFDPISVVAANIDELAALKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAM5</accession>
    <name>A0A194XAM5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_782376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071549.1">
        <property type="nucleotide sequence ID" value="XM_018222574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAM5"/>
    <dbReference type="GeneID" id="28832300"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782376"/>
    <dbReference type="InParanoid" id="A0A194XAM5"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="158" mass="18088" checksum="B1E8A6B6AFDC8B52" modified="2016-10-05" version="1">MPINQGLMKRNPDLTPEQFSESWYKDHRPLLVPYFLSCGITYYAQIHAPLSTTSPDIDISEWSGAAEMPSEDVLKIWALSTLVPQWKQDYYDEVIRADEIRLLGMLAHEQILQVGPGTVKGERKILIKDGKAVVEVPEGAWEVWRTYEKRGEGLEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCG3</accession>
    <name>A0A194XCG3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-alkane-inducible cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_684487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071792.1">
        <property type="nucleotide sequence ID" value="XM_018214893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCG3"/>
    <dbReference type="STRING" id="149040.A0A194XCG3"/>
    <dbReference type="GeneID" id="28824619"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684487"/>
    <dbReference type="InParanoid" id="A0A194XCG3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="497" mass="56955" checksum="4249817A637CE570" modified="2016-10-05" version="1">MNRSLEVAWALVAFPLIIFFFNYISKRWRRYLLASSRGCKPAPRHKQKGPFGLDFFIKSMKASLDHRRMEFTRDLFNKYDRTWQVTNFGKEFIFTIDPMNIQWVMVHDFESWGLEPLRLPAVAPYMGPGVFTTDGQFWAHARAQVKPILGKAQFSDLSRLEYHFQNFLPLLPRDGSAVDVQPLLERLGTDIVTEFILGESVGTLTENSSVDHKKFLGALSDADAGVGKRFLLGKLRFFLRDKNFDKACQIAHKYVDERIDAYFNTVATRKSSSQEPQPLVLLNELAKETDDRKLIRSQILNILQAAEDGAAIIISNTLFLLSRHPDVQRTLREEISTINAQIPTFEVLKSMKYLRKVINESLRVLPLAPNNSRVALKDTILPRGGGPHGKDPVFVEKGMIYGTNSYILHRDKETWGEDADDFKPERWETQRHGWHYQAFGGGPRTCPGQGLVLTQISYTLIRLFQEFKAIESRDERPWLESIKLTMCNGNGVILSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCH7</accession>
    <name>A0A194XCH7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_732584</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072230.1">
        <property type="nucleotide sequence ID" value="XM_018219698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCH7"/>
    <dbReference type="STRING" id="149040.A0A194XCH7"/>
    <dbReference type="GeneID" id="28829424"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732584"/>
    <dbReference type="InParanoid" id="A0A194XCH7"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ17875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="10892" checksum="1F1962B18D63CFEF" modified="2016-10-05" version="1">MTVTEAVKSAVGLSSAPAPATREEMREARLPLAYRDSCANLLIPLNRCRYEEYYLPWKCETERHSYEKCQYEEFKKRVAKMDELRAAKGGERSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDQ6</accession>
    <name>A0A194XDQ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_644385</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072670.1">
        <property type="nucleotide sequence ID" value="XM_018211838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDQ6"/>
    <dbReference type="STRING" id="149040.A0A194XDQ6"/>
    <dbReference type="GeneID" id="28821564"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644385"/>
    <dbReference type="InParanoid" id="A0A194XDQ6"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268108" description="Probable alpha/beta-glucosidase agdC" evidence="18">
        <location>
            <begin position="23"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="20">
        <location>
            <begin position="126"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="19">
        <location>
            <begin position="277"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="21">
        <location>
            <begin position="718"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KUJ18315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="931" mass="103007" checksum="E3DB8DAD55406678" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEH4</accession>
    <name>A0A194XEH4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_780599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072901.1">
        <property type="nucleotide sequence ID" value="XM_018222397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEH4"/>
    <dbReference type="GeneID" id="28832123"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780599"/>
    <dbReference type="InParanoid" id="A0A194XEH4"/>
    <dbReference type="OrthoDB" id="3563424at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="56956" checksum="93F108226D1D4B33" modified="2016-10-05" version="1">MTYGDMKDDKSFPSLNSDLDLNNLFTANSTILPSKTSHKLPRNTQNKIYSMASIKSPKDTGQEPNLQTMNTNTNNPPPESEANGQTEVERDKLDDEKSSSEQLMPARIPYNNGYGDFCFGRWALRRRVCDWTGTVQDQEFWEKGSNGVVVPELDGFKRDGPFPFFSLPLLVRDMIYRLLLGPLYEYDENDKTSYIRLYVEQPEKSHADRYEHGYEHFIGMERKASAVELDDPNSSTKPETTIEEYEQQLIVHRHKYAVHPSRSTSYQIGLFPTWQGGSLKEERTDSWYLEWLRKLSNVSNKFRHELGHVFWTRIAIDASLPTMRGPYSVLQLLHDRSSIHAGIKDITVKVDLEAETQGLVMTAALVNFKELCDFIGDRLVLETFCVQLEMEEDSLSDIFRSEYLMDYLQPGRQLQVRKRFSVQSAIYLNNNHKSHSSEEWDDFTENLRMKYEKFITDVMLPDTLRWKPATDEMNVYLQSRSDSLVVPPSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XES3</accession>
    <name>A0A194XES3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_683593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073045.1">
        <property type="nucleotide sequence ID" value="XM_018214731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XES3"/>
    <dbReference type="STRING" id="149040.A0A194XES3"/>
    <dbReference type="GeneID" id="28824457"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683593"/>
    <dbReference type="InParanoid" id="A0A194XES3"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="16242" checksum="CEE604C48DED6106" modified="2016-10-05" version="1">MAAGVPLTDDDRAGWLANLAAAGIEALSESSLVVVACSALKYKYREVFRTAVDKANNVEDRSVVLADTGNIQLDFIFLYMSQKKAKKLVRARALSTGHFMPASLVSSQFDILEMPNEKEPDCHIFDSNVGVEEVKDGTLRILDALLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XET4</accession>
    <name>A0A194XET4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_774743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073055.1">
        <property type="nucleotide sequence ID" value="XM_018221977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XET4"/>
    <dbReference type="GeneID" id="28831703"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_774743"/>
    <dbReference type="InParanoid" id="A0A194XET4"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ18700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="28760" checksum="6BB98AAF76CAB63A" modified="2016-10-05" version="1">MRTKEFLAVAGSLGLAGAQAPPVSTLSTTMSGVLPYLPVSTGFTGVETIEGAIVYDGPIVDGFTGPGGNATIQTNNPAATYMATLPMTQFDDATSTTIMGTVTGMANSNGTGVMFYIDFSGFPAESEYGPFVYHIHNMPVPADGNCTATLGHLDPTDRGEYHPCEDTQPETCQAGDLAGKHGNITSSTFNSSYLELYLSTTPGSPYFFGDKSVVIHTSNTTRLTCANFAMVSSTSANSTSTMSGTATSTSAPATYTGAADKIVGSGVLGLIFAALGAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFK1</accession>
    <name>A0A194XFK1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_582774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073276.1">
        <property type="nucleotide sequence ID" value="XM_018209181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFK1"/>
    <dbReference type="GeneID" id="28818907"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582774"/>
    <dbReference type="InParanoid" id="A0A194XFK1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="27885" checksum="47BA293E9E4C277A" modified="2016-10-05" version="1">MVSTSEAIAYAEICVYIPTFILTLFVVFRHGFKRQAGWIYLAIFSLIRVAGAGFKIAQSHNPTNKTDIEWAAILQSVGLSPLLLASMGLLKRVNVAANSGIANIITKRATAHSRRSRVIQIAALPTMIALALAIIGGTDEADSDASDISNGKKYMKIAVIMFFCIYLLLCALTVITMTDVGNAPRGEKRIYIAVLAALPLLAVRLLYSILAAFVNNNDFSIFGGKPLIQLFMAIIEEFVIVLFYTLVGLTSNKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG97</accession>
    <name>A0A194XG97_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_683115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073548.1">
        <property type="nucleotide sequence ID" value="XM_018214644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG97"/>
    <dbReference type="STRING" id="149040.A0A194XG97"/>
    <dbReference type="GeneID" id="28824370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683115"/>
    <dbReference type="InParanoid" id="A0A194XG97"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23278" checksum="B37DBB7A731C60D7" modified="2016-10-05" version="1">MLSTARSRAFVRLSRRAQFSARRAYAFSANDNKEINDPTPSKEVPNVSKSNEVPIETPHRDAPLQESIEEAEKLRVMQAPNRATVWSRSQNPRAKAMSGPRFEQTIMELQPAPQAAIDLIHKQPVRWTHERVVACDGGGGPLGHPRIFINTDKPQICMCTYCGLPFANEHHRKHLEALPDTAYPLAPRGDAAEIPESQRITDEALGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG98</accession>
    <name>A0A194XG98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073516.1">
        <property type="nucleotide sequence ID" value="XM_018214637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG98"/>
    <dbReference type="GeneID" id="28824363"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683089"/>
    <dbReference type="InParanoid" id="A0A194XG98"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="106" mass="11452" checksum="BEA579E96C9D02CB" modified="2016-10-05" version="1">MVLTRSQRKAALESGSSVTATTDHNDASKPPKSSNVAREEPLAQSDKTTAEDATTPSLNVVLKPAPKKAKPKLRAKTDNEEVPMLVYKVTMDDLMPPPSESVVEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGY5</accession>
    <name>A0A194XGY5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073783.1">
        <property type="nucleotide sequence ID" value="XM_018219622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGY5"/>
    <dbReference type="GeneID" id="28829348"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731825"/>
    <dbReference type="InParanoid" id="A0A194XGY5"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="65"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="326" mass="37165" checksum="7275AF029125FBE1" modified="2016-10-05" version="1">MARTKQCARKNPGDWAYRPGWNCYEKRPHQPTTTSGPSSTQTEALIPSNPFSASNSTIPIPDLSRFRTLPFEIRTSIWEAFACLQRIVTIHAITDRGLRAPIPPILHVCAESRAVGSKHYTLSFGFRGSTDFNDVSERWDDHPALEAKVYFNFERDVLYFGREWNEGIVGQWSCANHLKRLVNGEDMKKVERIGFDVDVSVCCQLAGRNHGPWLVPWTGLKKVYLGLRDPLPAAESLSYLRSSKPDWKREGLLEALGPDLYEEFVKRYRGVGIWLEVPEELSGEEAVEFIRTRLGRVYGTQHGAFHVQHGEEDFHDMFTTALVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH25</accession>
    <name>A0A194XH25_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_613075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073784.1">
        <property type="nucleotide sequence ID" value="XM_018210652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH25"/>
    <dbReference type="GeneID" id="28820378"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613075"/>
    <dbReference type="InParanoid" id="A0A194XH25"/>
    <dbReference type="OrthoDB" id="3443855at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="11152" checksum="878B94FA29013989" modified="2016-10-05" version="1" fragment="single">MLQRDLKSFPPPGTKSFFRNKRDEEFASRQRNFDKLPKPEQQENEVWVQDYMKRSGPCPQNFKWERRGKGLHCTGGNHYVTDDLIAEGKGGMMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH91</accession>
    <name>A0A194XH91_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_546028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073849.1">
        <property type="nucleotide sequence ID" value="XM_018208241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH91"/>
    <dbReference type="GeneID" id="28817967"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_546028"/>
    <dbReference type="InParanoid" id="A0A194XH91"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268284" evidence="2">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="390" mass="41532" checksum="535D714055A17EFD" modified="2016-10-05" version="1" fragment="single">AVFLAGFAALTVASPASQVIDFASVNAAPSPSLTGPPPFATINEVSINIASVAAEGSAAVTGVASASATASQAVNAKRVWGWDVTSVSSTTSSTTSCPTTPEPGTYCGFINPEDACAIQPDGYGPHVEPDTPDAFLAYPEFHEEARAAKAPAGYVETFVDLNASVSANTYLGLQTLQSYDVSLCAQYCDSKDLCTGFNIFFERDPSLNPSANCTQPASITNYKCTLWGSGVYTASATNYGDYRGEFHVVITGSDGFEKTNTTTPPSQPGWQPPQQCGSDGGSVHNHPNNCMGTSFFPGPYNPAVCANYAQAQNSQNKQSPWWSQWVNAWTGYNSHQCDFFNSYMLKKNGHPLGTYCALFSQSYSGGEAIYTPGWQGSDYWSIESSWGWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHE2</accession>
    <name>A0A194XHE2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_580390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073985.1">
        <property type="nucleotide sequence ID" value="XM_018209055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHE2"/>
    <dbReference type="GeneID" id="28818781"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_580390"/>
    <dbReference type="InParanoid" id="A0A194XHE2"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="29872" checksum="80BD2C8BD0D74462" modified="2016-10-05" version="1" fragment="single">MNTSIEDFDRWQAHIGLKTFGEGLNAAAKAIFPNESRSRYTKVYVLMLSWADEDPDLPVSIEILKLYKVFKDIYHFDVEVWRIPDEACHIEVNQKILDFVKLGGDSDDHLKIVYYAGHARLTKNRRLAWTSGQRSRNGKTPTVQWSGIQNALEHSQSDVLILLDCCHAGTANNNEGNGVTELIAACAYNSLANGVGSFSFTRELEIELRELAKLPSFSIGNLYHNIFCRIQARMSDDERDHPAPVYLPLTQEDPRYPRSIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHQ6</accession>
    <name>A0A194XHQ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">LY89DRAFT_567825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018208559.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_567825"/>
    <dbReference type="InParanoid" id="A0A194XHQ6"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ19664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="34993" checksum="47460D3426F5D78D" modified="2016-10-05" version="1" fragment="single">STQPRTPQSPSQAHPAHELPSKPGTSPRPTNSLPTPAHSINGSKSYSEAFAPELIADVALLNESHNKRKRDIEDNGDQEHKKAHVEISRLSIDDLHLDVGKKYLLCKNQHHTRLPALSDDLFSMYGLNDLAKSVARTGPDGQSKGVKLRKTYKNHIKDHGVSGAFDSKKREFDAPESLFMMMITPGEEWDAQHAQGKDIEKGLGLDDNVLSKAFTMSRGSIPKAMWDSSVLGELAATPAPEPAKAVQNAARMAQPQAGGVLRTAKSEISRPKRATKKRTYQDSSFEGYGEGYVDDDVQDVGYSTGDGDDRGASRKRPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI16</accession>
    <name>A0A194XI16_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_731115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219544.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_731115"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="190"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
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        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="93547" checksum="CA74112834E3EE74" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI21</accession>
    <name>A0A194XI21_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BcCMK3, calcium/calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_731120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074225.1">
        <property type="nucleotide sequence ID" value="XM_018219545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI21"/>
    <dbReference type="STRING" id="149040.A0A194XI21"/>
    <dbReference type="GeneID" id="28829271"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731120"/>
    <dbReference type="InParanoid" id="A0A194XI21"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="105"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="773" mass="86130" checksum="FDBB9A1230C778B6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJN5</accession>
    <name>A0A194XJN5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_771242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074723.1">
        <property type="nucleotide sequence ID" value="XM_018221879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJN5"/>
    <dbReference type="STRING" id="149040.A0A194XJN5"/>
    <dbReference type="GeneID" id="28831605"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_771242"/>
    <dbReference type="InParanoid" id="A0A194XJN5"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268385" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="375"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="969" mass="103708" checksum="E4057DB1708E07B8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJS7</accession>
    <name>A0A194XJS7_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_730410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074719.1">
        <property type="nucleotide sequence ID" value="XM_018219476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJS7"/>
    <dbReference type="STRING" id="149040.A0A194XJS7"/>
    <dbReference type="GeneID" id="28829202"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730410"/>
    <dbReference type="InParanoid" id="A0A194XJS7"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268321" evidence="1">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="57057" checksum="7C731F8A10BB7F78" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKG7</accession>
    <name>A0A194XKG7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_730722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075060.1">
        <property type="nucleotide sequence ID" value="XM_018219506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKG7"/>
    <dbReference type="GeneID" id="28829232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730722"/>
    <dbReference type="InParanoid" id="A0A194XKG7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="18553" checksum="9D3C0AB0C5BD5725" modified="2016-10-05" version="1">MADQAADKAADKISDQITQEFKDQIPEVPSKDSSKEKILKYASDRLKAAEDAEAKAAAARERAEACEDPEEKKKILAEAEKEERKSKAEMKAVNRIQSGVWQGAGMGGGMGAGLGMGIGAGVGTLLGGVVSIPTTGLGILAGAGTGAIHGPWFKLPGAEGMKENRGDEEGGEGKVEGGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKS2</accession>
    <name>A0A194XKS2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_578381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075185.1">
        <property type="nucleotide sequence ID" value="XM_018208937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKS2"/>
    <dbReference type="GeneID" id="28818663"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578381"/>
    <dbReference type="InParanoid" id="A0A194XKS2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268340" evidence="9">
        <location>
            <begin position="19"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="587" mass="63432" checksum="2BB08B3086828040" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLM7</accession>
    <name>A0A194XLM7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_577205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075438.1">
        <property type="nucleotide sequence ID" value="XM_018208877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLM7"/>
    <dbReference type="FunCoup" id="A0A194XLM7">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLM7"/>
    <dbReference type="GeneID" id="28818603"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577205"/>
    <dbReference type="InParanoid" id="A0A194XLM7"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="77"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="384"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ21083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="473" mass="52002" checksum="ABC89608B7CD6391" modified="2016-10-05" version="1">MRNDSTINGVMIGLLSSFGSAVLIAFIFLIVYFFRYTSSGRILLDRIGRPGEFDDEQAFLRDENEALESMDDIQRQEYLRAKAFIQANPPDSLPTDISLSQYLAIQEKGVSAWEFEPELEIANCFVEGRTEIEFFDSECSTLTNLPIPKQNEVYYWESKIYDKPESTLISIGVCTKPYPLFRLPGWHKYSVAYTSTGHRRYNQPFSGPTYGPQFVQGDVIGVGYRPRTGTIFFTRNGKKLEDVAHGLKSQNLFPAVGANGPCTVHVNFGQSGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLEAGREGSQSSQGHYPDPRHGRTRSGNFRYGPPTSPGPVRSPTDISLAHLTHIPSNDEPGESSASAGAVESGISTVTPANVGLGLHDHTQPPPEYTSPQASNASSPRGSSDSERAPLVRRKSTPPPIPSYNETVAEDRARERSQSHAQRPNRTREEDGSGSRPRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM78</accession>
    <name>A0A194XM78_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_577330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075705.1">
        <property type="nucleotide sequence ID" value="XM_018208886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM78"/>
    <dbReference type="STRING" id="149040.A0A194XM78"/>
    <dbReference type="GeneID" id="28818612"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577330"/>
    <dbReference type="InParanoid" id="A0A194XM78"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="35172" checksum="F61335D67E14DD0D" modified="2016-10-05" version="1" fragment="single">LKTNYRLGGIVHSLRDPLPVRGTTMIVGADVTHPGKVNDTTCPSMAGVVATYDTYYMTYLASARLQKKNTEHISDLKGMMKERLHAYKSKNGGSLPEHILFYRDGVSESQFGEVRATELPQIIEACKEEAGAVPRPRITLVIVIKRHHSRFFPNPENRQNNKSGLLVDETVVAPKQFNFYLQAHDSPIGTARNTHYVVLENESGYNADELQSITNKLSFTASKGTKGLSVCTPARYADTLCDRLRRYMRPALELDRSVNYPNYPDHTLINYNHDVVIWNAPRAAIKVNGRTTVEARTNPWRPELNDFMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMI2</accession>
    <name>A0A194XMI2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_681613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075337.1">
        <property type="nucleotide sequence ID" value="XM_018214334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMI2"/>
    <dbReference type="STRING" id="149040.A0A194XMI2"/>
    <dbReference type="GeneID" id="28824060"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681613"/>
    <dbReference type="InParanoid" id="A0A194XMI2"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="10">
        <location>
            <begin position="799"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="877" mass="94736" checksum="8F96F57ADD2CF806" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNW5</accession>
    <name>A0A194XNW5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_768042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076211.1">
        <property type="nucleotide sequence ID" value="XM_018221771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNW5"/>
    <dbReference type="GeneID" id="28831497"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_768042"/>
    <dbReference type="InParanoid" id="A0A194XNW5"/>
    <dbReference type="OrthoDB" id="3437109at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="135" mass="15173" checksum="2508C85E83ECDC13" modified="2016-10-05" version="1">MVINVDDVYIALHHHWILDVSIFPDGRQRLQLALLILVCAYTASRPGALVYVERNIKVKKSTSPILDDSLDEMDELDADEMDVDDDPTSPEEHIEALKTLCYEDVTLVLLPNLAGIRDIFAMEVNSTSLLGKLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPA1</accession>
    <name>A0A194XPA1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_681406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076430.1">
        <property type="nucleotide sequence ID" value="XM_018214287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPA1"/>
    <dbReference type="STRING" id="149040.A0A194XPA1"/>
    <dbReference type="GeneID" id="28824013"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681406"/>
    <dbReference type="InParanoid" id="A0A194XPA1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000050">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="41"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="145"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="598" mass="67642" checksum="91CDBD29FF89BFE9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ89</accession>
    <name>A0A194XQ89_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_680458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076681.1">
        <property type="nucleotide sequence ID" value="XM_018214083.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XQ89"/>
    <dbReference type="GeneID" id="28823809"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680458"/>
    <dbReference type="InParanoid" id="A0A194XQ89"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="446" mass="49276" checksum="AD8BDD0289A6782A" modified="2016-10-05" version="1">MAQAQPSDIGFGYISNNEPSRHIVEIPAMPASPGPLKSAMKVPGTPGRRIDNPLSPTFREEQILEKHEEFTEKEQAKDLKVKTRVRIAKFILRGVNFSCSLIVLSMVSVTFSIFESTKALPARNNLPAWAVGTKTWPQKVILATSCVSLALCLCIFWNYWRGGHRRAEKVAVYYTLFAVGFFVFSTIMWAMAAGILQGAKSNSSNKDIWGWSCVDNKRRDLFSEKVDYALVCRLQSWSLICCLIEVVLECITIILYGVVFYRYYSKQRLRKSMDVRDRARSDLYLAQLRSQSAPNTPGFGPLSPSYSTHMKSPRFPPAAYSSNLDSMAEEGFGPGTRFVEAKPASAKPAKPFALQPPPIKVHAATPKTPQAGFDAPAPRKERVIEHVAAAPGEQTYDAVPIPGAYASPLNSPGMTQPQHTRFGSVGEAITSDVRIESPPGSPRGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQM9</accession>
    <name>A0A194XQM9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_301176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076858.1">
        <property type="nucleotide sequence ID" value="XM_018206576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQM9"/>
    <dbReference type="GeneID" id="28816302"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_301176"/>
    <dbReference type="InParanoid" id="A0A194XQM9"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="245" mass="26482" checksum="208292D954F01FB3" modified="2016-10-05" version="1">MSLSRAFTTRRAKAASAEATPDMPKRSITVRSGGTIRHKISAPIELISTTNMLSYNAPDIFPSSSSSTSSHSGDESDRSPSTFSSPLTSPDSSSIESSSPISPEPNHLSCYFGAPSRQSASDSEAPVVPKRAVSHTKSASLQRSASRMSSRKTSTSTARSSINMFSGNVETVEHHPFGNELAQVSELAEEYGISKEKLAIVDEEEQELVSRGLFKFRAEDYMSEIHGLFMSAFGDARPTMSSMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQS8</accession>
    <name>A0A194XQS8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_681411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076437.1">
        <property type="nucleotide sequence ID" value="XM_018214292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQS8"/>
    <dbReference type="GeneID" id="28824018"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681411"/>
    <dbReference type="InParanoid" id="A0A194XQS8"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="37398" checksum="0392047165C7FDE5" modified="2016-10-05" version="1">MATHTTSVTPSSIPVPVLKLNNGVEMPALGFGTFAKEGVEGKTYEAVMAALDAGYRHLDCAWYYLNEDEVGTALREWLDKNPEVKREDLFITTKVWPHLAEPDDVEWSLNNSLQMLGTDYVDCFLIHWPFAAERTEDRNVELGPDGKYIIKNGLTEDLSPTWRTLEKLYKLGKARSIGVSNWTITGLERLLEYAEIKPAINQVEIHPFLPNSELIQYCMSHNILPVAYSPLGSQHQVPTTGEKVLTHPELTSIATKKGISLVQLLVAWGLKRGYAVLPKSGNAERIKSNFCLVELNEEDFEAVNKIAEGRHCRFVNPKEMFGYDVWSEESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQV9</accession>
    <name>A0A194XQV9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_693820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076794.1">
        <property type="nucleotide sequence ID" value="XM_018216661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQV9"/>
    <dbReference type="GeneID" id="28826387"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693820"/>
    <dbReference type="InParanoid" id="A0A194XQV9"/>
    <dbReference type="OrthoDB" id="3432186at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="32970" checksum="0C473F1E048F3918" modified="2016-10-05" version="1">MRLLNTATIVVQEFNDNNLPPYAILSHRWEDEEVAYQDLAGDRGHTMKGYAKLKNFCRQALSDSWQWVWMDTCCIDKSSSAELSEAINSMYNWYRDSRVCYVYLSDVPPEVDMSFHIQEDSPFRKSQWFTRGWTLQELLAPRYLVFYDREWGEIGTKSCLETRKMSWASNRQTTRTEDMACSLMGMVESLLRLQLEIIKNSDDVSIFAWFDENDDSTGMLAPFPSCFRTSGNVRLLYSQRLKRPYTMTNKGLHMPLFLAFKRNLMANFLSAIEELPRYEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR76</accession>
    <name>A0A194XR76_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_307774</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077048.1">
        <property type="nucleotide sequence ID" value="XM_018206610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR76"/>
    <dbReference type="GeneID" id="28816336"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_307774"/>
    <dbReference type="InParanoid" id="A0A194XR76"/>
    <dbReference type="OrthoDB" id="5426355at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268559" description="CFEM domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="13">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ22693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="26737" checksum="2C5E67187F3F7392" modified="2016-10-05" version="1">MRPSIAAVLSVLSTLQFTNAQTANGVIVPFSTLPACAALCGPLFDVQGKCSPPASATVDDSCFCSDSRLTPFTTGTAGVSQVCGSASCSATSDLQAIETWYTSFCASNNAVTAATTTASSTGSTATSTSTSNTNGSSSSSSSSANKSWLSTHYKWVIMLVVMFVVIVGTWVAACLFRRRYLRRKEKEIEMLPPVALGPHQLQAMTGGYRYGDGVLDANRGGHAGGHHKEMAAAEATAANGAKRQSRGLTKKRDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRY4</accession>
    <name>A0A194XRY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_776784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077308.1">
        <property type="nucleotide sequence ID" value="XM_018222077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRY4"/>
    <dbReference type="GeneID" id="28831803"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776784"/>
    <dbReference type="InParanoid" id="A0A194XRY4"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="352" mass="38424" checksum="EB32E882F9EEE0D0" modified="2016-10-05" version="1" fragment="single">MPEPLQSAWNRLQSREEPGLATRDNGQTITTSDGLFLFPLRIGSPQQMLNLIFDTGSGDFWVWSWLMPDTQTSGRNYYNGSNSSTATRWQGQSFGVDYSAGSLHGLVWQDAVWVDNIGVGGNPIECAQDVAPFFLNLEGADGVLGLSNAFNDSESPAPQQTWLTWVLPRLPASVFTVALSPKSMGTIDFGFIDSSKYIGTIAYTPVTIIPGTTGGFWAFNWTGFAIGDQKFNYTNIQVMVDTGGNISQLPQSILKKFFAQVKGAYQQSDGGWNFPCASAVPNLTFGVGNSRIVISGKNFIFNPLADGINCYSAVQGTSDGSYVYMNVPFLESIFVVHDYGAMRMGFANRTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS55</accession>
    <name>A0A194XS55_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_693294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077331.1">
        <property type="nucleotide sequence ID" value="XM_018216624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS55"/>
    <dbReference type="STRING" id="149040.A0A194XS55"/>
    <dbReference type="GeneID" id="28826350"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693294"/>
    <dbReference type="InParanoid" id="A0A194XS55"/>
    <dbReference type="OrthoDB" id="5399305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36972" checksum="BAE4C96CD18C9BCE" modified="2016-10-05" version="1">MSTPTQMNTSAHVAQSNYSPVDAINRHDFGVQKNRKQASTGGGRAWSEDEEVYLLQTRLQKMPYKHIAAHLKKTELACRLHYHQLSHGSNRRKRTNSVTSSNAGSVMHSPVMQASMPSPINEHAMQPVTPPTYSYSPQSPVHVQLPSASTLLHRSGSNSPPRTLAHPVAILPKPSPPRRALSDSAAPLRLDCDVATNQLNISNVDKERLRHIYEAHRASFWGVIAAEYGAGASPLLLEETWKRGIATNAPPTPCVSPDTQTIRSGAYQGYNTKPMHQLPTPVQENKSNATSISALLGIDASPRSPKEREMIKRMEERRETRDIVMAGVEMGQRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSS7</accession>
    <name>A0A194XSS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_170654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077551.1">
        <property type="nucleotide sequence ID" value="XM_018205568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSS7"/>
    <dbReference type="GeneID" id="28815294"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_170654"/>
    <dbReference type="InParanoid" id="A0A194XSS7"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="192" mass="22146" checksum="0E90AECEB6D3C973" modified="2016-10-05" version="1">MVDSATISSSLSYGELLKENQQLRLRLNSQTRKLPQNPLKRVEVGNVTGSFEKDLFDAVKHSARVSTVTGESMSSIQVSIVLQDFCHTARYGCLGSILRSTILPRVGVRVFLAKRSSTRDYRWEQITLACYIFQLSEPLFYLYQGDFLRNMDLKSVQAIHTWYYVQQCGRCDVPYVFMGLWNQNRKRPGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSV0</accession>
    <name>A0A194XSV0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_777056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077628.1">
        <property type="nucleotide sequence ID" value="XM_018222101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSV0"/>
    <dbReference type="GeneID" id="28831827"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777056"/>
    <dbReference type="InParanoid" id="A0A194XSV0"/>
    <dbReference type="OrthoDB" id="3561897at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="55" mass="5845" checksum="8D00C203D3A9B27C" modified="2016-10-05" version="1">MPALDPRIVQGLSEVGASILVARDSVPKHEIIEAFLVIFVSVFGVGGAIIWAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT95</accession>
    <name>A0A194XT95_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family 3 O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_713885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077778.1">
        <property type="nucleotide sequence ID" value="XM_018218087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT95"/>
    <dbReference type="STRING" id="149040.A0A194XT95"/>
    <dbReference type="GeneID" id="28827813"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713885"/>
    <dbReference type="InParanoid" id="A0A194XT95"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="28896" checksum="9B735574F5A3F5ED" modified="2016-10-05" version="1">MPSHKFHPSEYAKFDQTHTWIETSLVHQSSAQLSCLATNEASHLDAIDVAPNEGKLLYLLTKLAKAKRVLEIGTLGGYSALWFAKAVAPLGGKVVSLELSPKHAEVARKNFEKAGFGEVVEIRVGKAVETLEKMGKEGEGEFDVVFIDADKENNVRYLEWAVKLGKVGTLVVVDNVVRQGKVLADGDAASEGVRRAFEWMGGNKRLEATAIQTVGPKGWDGFAVAVVVEGCLGSDEWAKKGKKLEAFEDSMKYFKAWQMVKDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTE5</accession>
    <name>A0A194XTE5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_728223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077833.1">
        <property type="nucleotide sequence ID" value="XM_018219243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTE5"/>
    <dbReference type="GeneID" id="28828969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728223"/>
    <dbReference type="InParanoid" id="A0A194XTE5"/>
    <dbReference type="OrthoDB" id="5273647at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="358" mass="39459" checksum="CD1516758B6B010B" modified="2016-10-05" version="1">MAYDLSVATARNPLIAITVFVAIAIATTALRFEARRMRKVPLAADDYLLLAALFCLFISVGDQYACVIAGGVGRHTVDVDPLDVVKTLKLILPFEALYGITLCLIKSSIICFYFRIFGNTRSFRISAYVVLAFIVCWALSVVLETFLLCRPVAYNWDTSIKGTCGDRNTVYVSAGALNVITDFMVMSLPVPHILTLQLKMKKKLGLLLMFSLGLFITIISIIRIKSLQVISFTDPTYTLPMGLLWTTLEPCLCIINANLPMVRTCLATYAPKAFGSTNDQTSRKTPLPGQSGSRSDPFDLIRDDRFGATDIKLGQIGTESRIHAGRRSQPLGDSDSERYLTKGDNHIHVGRSVDVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUW6</accession>
    <name>A0A194XUW6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_571581</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078184.1">
        <property type="nucleotide sequence ID" value="XM_018208599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUW6"/>
    <dbReference type="STRING" id="149040.A0A194XUW6"/>
    <dbReference type="GeneID" id="28818325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571581"/>
    <dbReference type="InParanoid" id="A0A194XUW6"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ23829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="19329" checksum="78B8484DE12BE3F0" modified="2016-10-05" version="1">MGLNMSKLLPASIGYVPIYIMVFGLEGAGKRTLASKLQLSSSTAYTTEGVLVMSMGYNNVRFEVFDVVAGKNVNPPLPAHFKGPLALVFVVDAHNREKISEAAEELHRVLIKPEFHNVPLLVFCNKLDVSQAMTKAEIETKLGLHALISGTWYTQGSSGSKGEGIYDGFQWLSNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV08</accession>
    <name>A0A194XV08_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_565525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078224.1">
        <property type="nucleotide sequence ID" value="XM_018208533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV08"/>
    <dbReference type="STRING" id="149040.A0A194XV08"/>
    <dbReference type="GeneID" id="28818259"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_565525"/>
    <dbReference type="InParanoid" id="A0A194XV08"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="179"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="182"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="375" mass="43364" checksum="3D7451A635D81B9C" modified="2016-10-05" version="1" fragment="single">HQPCESFFVEDAYPQRSSAHEYAKIVGRRKQEAMANELSRQASEAYLEDIIGHMKHMENETLPDVASIDIQQEIQWFMRPYLIDFLIEAHAAFQLLPETLFLAVNLLDRYCSKRVVYKRHYQLVGCAALLIAAKYGDRKERVPMIRELKSMCCSLYDEDMFTQMEWHVLNTLEWMIGHPTVDSFLQIAFNDRPAYEDLEVEHMSWYLCEIAMYHKDFVSRKPSVMARASLALARNILGRPDPFDGKDFEVSDVIVKLYSKVRTPSQVLFRKYATPHMSQVAGILEHTVQQQEAMNRRASPPTPPCEIMQKPINTVDMYPNTPQKQPYGNVVNGYPTPPITPEGEYFVNENEKYHQAPRCPITPTPSGNNPFVHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVB2</accession>
    <name>A0A194XVB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_713155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078625.1">
        <property type="nucleotide sequence ID" value="XM_018218031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVB2"/>
    <dbReference type="GeneID" id="28827757"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713155"/>
    <dbReference type="InParanoid" id="A0A194XVB2"/>
    <dbReference type="OrthoDB" id="10676581at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="464" mass="51399" checksum="FEE76A3F006ED4B0" modified="2016-10-05" version="1">MRQCLTFVEHIEDRSFRRRKEQQAKVNAIKRRQRSTPQLRIPKPPIPGYRSTQPRASIPSLQVQSHTMLRATVSTKGPYMTSHQQIAADSIEGRIQSFLQEVKGLSYAPFASALVRFVKDRNTVDDEYLRVQKNKLLLALDGVVDLCKTQSNALLDGVTEATTKEVGRIRNGLLGVPDPDLGTSVPGNDSLSVDLATVDGLFMLLEVAPDQTPPNLVEPLFVGQPPKVARLPRNAAEYNQILKYNRKLSNEALVLHSRSLESRVDEALKLVLNKFQDDLKREKTKVKGRLNNAERAAHKTFEDNLETSQEGLLALLKQLESAEDTVNKLADIKRANDDDTRLDLEEAQAEAQAKAHAVVGSSSVQGKASTPIIIDDDTDHEADEPAKRHDTASTYGRVEYWDGKGQLPVSGEGSKYAHGFIEPVIEDASAANVKTRRIVLTGKENLPLIGAKKRKLSPDGFTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVG0</accession>
    <name>A0A194XVG0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="6">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_634019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="6"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078476.1">
        <property type="nucleotide sequence ID" value="XM_018211372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVG0"/>
    <dbReference type="STRING" id="149040.A0A194XVG0"/>
    <dbReference type="GeneID" id="28821098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634019"/>
    <dbReference type="InParanoid" id="A0A194XVG0"/>
    <dbReference type="OrthoDB" id="2525337at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF13">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268640" description="AA9 family lytic polysaccharide monooxygenase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="8">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="26137" checksum="03500980E5F594E2" modified="2016-10-05" version="1">MRTSILFSLVAFTASAVNAHAIFQRIKVNGVDQGQLVGVRAPAVDNPVKDVTSPDIACNTGLKAPVSTAVVTVPAGAIVSAWYQHVLGGPQMAGDKDNPIAASHKGPLMVYLAKVDNAGTASWTGLEWFKIAEEGLDITTGKWGVDTMIAGNGWWSFTMPSCVAAGQYLMRVELIALHSAYASGGAQFYFSCSNVKITGSGTTIGNDTAKFPGTYAANDPGILLNIYNGTLPNNDLKPYAIPGPKPMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWQ2</accession>
    <name>A0A194XWQ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_727192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078512.1">
        <property type="nucleotide sequence ID" value="XM_018219125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWQ2"/>
    <dbReference type="GeneID" id="28828851"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727192"/>
    <dbReference type="InParanoid" id="A0A194XWQ2"/>
    <dbReference type="OrthoDB" id="3480289at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="279"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="534" mass="60231" checksum="8F3177DF880E1577" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B375</accession>
    <name>A0A132B375_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_726259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061210.1">
        <property type="nucleotide sequence ID" value="XM_018219040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B375"/>
    <dbReference type="GeneID" id="28828766"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726259"/>
    <dbReference type="InParanoid" id="A0A132B375"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="29387" checksum="6BF064D56BCD6649" modified="2016-05-11" version="1">MPLGQKSNPQPPKIQIACVSCKSRKRRCDGGTPQCRNCIARGEECVYATARKKRGPGKKKFQIESPGDPVQLPTNELLNTSSNPNDHPQIDPHLETQTLLPRPEIFPTFLLPETFTANLRTFRSNHTQNQTYTPLNLIPLPLWLRMTTHVLSTVPSLSRLQLTASTFQSHPLSQYSTSPSSPGSDPARWALVNTVLALCIKCKIAREAEGALGCVHEALWKNAVGVLPDLILGERSAEVVLALRVMGIYAKETEDKGLVGFFGGVVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3R1</accession>
    <name>A0A132B3R1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061400.1">
        <property type="nucleotide sequence ID" value="XM_018220945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3R1"/>
    <dbReference type="GeneID" id="28830671"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743368"/>
    <dbReference type="InParanoid" id="A0A132B3R1"/>
    <dbReference type="OrthoDB" id="3535086at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13167" checksum="2BB1C5D87CFE54CE" modified="2016-05-11" version="1">MISSLQPSRPKVPPSNSSPPLNQQPTRTFTSTPGPPTFQYLPPRNQIEAMPPTVPLPTTLVLGHPQQQFQSAMRHPVFFTDRFKKAPPGVNSGNGSWSTPVAEGYVYNDGVRKGVDGSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4J0</accession>
    <name>A0A132B4J0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_726066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061284.1">
        <property type="nucleotide sequence ID" value="XM_018219025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4J0"/>
    <dbReference type="STRING" id="149040.A0A132B4J0"/>
    <dbReference type="GeneID" id="28828751"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726066"/>
    <dbReference type="InParanoid" id="A0A132B4J0"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="23"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="528" mass="57936" checksum="CF26372C70CC3C4D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V5</accession>
    <name>A0A132B4V5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinesin-associated microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061716.1">
        <property type="nucleotide sequence ID" value="XM_018216415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4V5"/>
    <dbReference type="STRING" id="149040.A0A132B4V5"/>
    <dbReference type="GeneID" id="28826141"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691820"/>
    <dbReference type="InParanoid" id="A0A132B4V5"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin-associated microtubule-binding" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="21980" checksum="592B4584440A2A0F" modified="2016-05-11" version="1">MRALDDFVTRARSQNAQYYDVHSKSLKSLSITARASYDSFGSQLAITHERSKSLDDDISEKQKLLDEALATLNSTLQQPLSDLRANISRTTLQEYKPTAETPQRTQYEYPTELPRTKPHENLIAAGSFSPLIISPSKSPLFSGPNPNANDESVKARPLVTSFSTSLPPREFSQTLSGLSASICAGGPSVDPWFLDCDDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V9</accession>
    <name>A0A132B4V9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_742681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061803.1">
        <property type="nucleotide sequence ID" value="XM_018220855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4V9"/>
    <dbReference type="STRING" id="149040.A0A132B4V9"/>
    <dbReference type="GeneID" id="28830581"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742681"/>
    <dbReference type="InParanoid" id="A0A132B4V9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40731" checksum="E3BAFB8D83101275" modified="2016-05-11" version="1">MPPKRTSSSKRDRQKLATAAQKLMTLPSASEPDEEESVVANNLTQALTGESEDEEIIEEERYLSATSTLSKQPNPPTSSAASKAFKCECQQGHTDGIECIIHNNRKVHAGISARVLMRSNMVYINNKFYVHADLLSLHSERFRREWGQTTFEEKEKRKGSMLWALKDKDPLIAHFSGWLYSGGLLATACFETNELQEELTAYRTGRFENDGFNKHWMVPKSLRSIYKVATQGSPFRKLASDIMSSLDVLNSEKYGPQEDWESLCEDLPELEADVKAADVEKNKGKWAGRGGRPWNNQYRKEYMLEEVPMEEVWENQILQQRNLGDLERMSKEKDVQAMIELEHVKGSQQSSEAKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5C7</accession>
    <name>A0A132B5C7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061970.1">
        <property type="nucleotide sequence ID" value="XM_018216387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5C7"/>
    <dbReference type="GeneID" id="28826113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691687"/>
    <dbReference type="InParanoid" id="A0A132B5C7"/>
    <dbReference type="OrthoDB" id="3600004at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF77">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="525" mass="60295" checksum="D418FA42432E87BC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5E6</accession>
    <name>A0A132B5E6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_359982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061991.1">
        <property type="nucleotide sequence ID" value="XM_018206989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5E6"/>
    <dbReference type="STRING" id="149040.A0A132B5E6"/>
    <dbReference type="GeneID" id="28816715"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_359982"/>
    <dbReference type="InParanoid" id="A0A132B5E6"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="433" mass="49917" checksum="2AF1DF06CE1579FA" modified="2016-05-11" version="1">MSTSRQENVKWVDGLRGIASLLVVLTHLTRAFDDALFKPTSAEGASPRLLQYPLLRILVQGRIGVPIFSLVTGYVCALKPIRLFATGNQERALLSITKSAFRRIPRLVLPASIATILIWIICQLGGFQVTKHVQSWWLIYTSPNQLPLGPAIVNLGLNLITTWVREWNVYEPNQWTLLPLLKGAFLVYMMLFSTAFMKPKYRMMVELALFVYYYIANDPEYGIHFFFGAFLCDLSQYTPYTEWISTRKWPSRILSPILILIGLLLASYPETKPEWMPWSNFMLKLADYIFPPNHPDTPRFYTGLGLTFLALGIHFSDFVKVLLSNKYLLWAGKNSFAVYLLHGTLLRTVLVWMEYGFVAPADVVHEDGSVSEGKHLELGGRLRFWFWIPVWFVLQYWLANLWTGYVDPFCARMTEKLEKYVFNNEEEKSVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5S9</accession>
    <name>A0A132B5S9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_569344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061599.1">
        <property type="nucleotide sequence ID" value="XM_018208573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5S9"/>
    <dbReference type="GeneID" id="28818299"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_569344"/>
    <dbReference type="InParanoid" id="A0A132B5S9"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="393" mass="42267" checksum="52C4206A59839215" modified="2016-05-11" version="1" fragment="single">LLPVPTQDPWFSPPTGWESTAPGTAMKVRYSPYRNISIGDCADTFQVLFRTSDTNNNASWGVTTVFIPASHTECSSTQPQNCSRGLVTYEVPYDSADPDATPSYLLQYGEPYGEIYELLKRGWFVNTPDYEGPLSSYCAGVQSGHATLDSIRAVLQVSQEFGLNASTARAAIWGYSGGALASEFAAELAGVYAPDLKLAGVVQGGTIPNVTSAGNKMTSKDTAGLAIAGIIGITSQQPAARKYLDSVLRNTGSFNSTQFYTATTMSGSQVLVAFENQNISDYFYNGTEALAAPVLVDVYNDDAVMGHHGVPNMPMFIYKAIHDEMSAAAETDLLVDSFCQQGANILYHRNRVGGHNEELWQGRGRALAYLSAVVDGTDEIDYPKTGCSIQNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B669</accession>
    <name>A0A132B669_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062260.1">
        <property type="nucleotide sequence ID" value="XM_018220852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B669"/>
    <dbReference type="GeneID" id="28830578"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742666"/>
    <dbReference type="InParanoid" id="A0A132B669"/>
    <dbReference type="OrthoDB" id="7873042at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12258" checksum="DA17463622527F42" modified="2016-05-11" version="1">MSLARIATSWANSQVTLIRNSGVSNAQRGVHVPPQNKYGQSTSWTPLFNPDARPAPVFVTKMQQIFACLDPGWIGYLSPEAGSGVSCSADHLYGSSESSEHGPRIIENLTQKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6M8</accession>
    <name>A0A132B6M8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_712082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062014.1">
        <property type="nucleotide sequence ID" value="XM_018217951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6M8"/>
    <dbReference type="GeneID" id="28827677"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712082"/>
    <dbReference type="InParanoid" id="A0A132B6M8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="26617" checksum="A61BE4FAE7672675" modified="2016-05-11" version="1">MRLLNVATLQLEYFTGEVGNGIPEYAILSHTWGAEEISYSEYNSRESLTKKGYEKIMGCCRFEGYQYIWIDTCCIDKICYAYLSDVGSAEDPSIEGSSFDRSLWFTRGWTLQELLAPAEVIFLSSDWVEIGTKSSLCAAVSRITRIGTKALEECLWNEYSVAQKLSWASGRRTTRVEDKAYSLMGLFDVNMPLLYGEGQKAFFRLQQEDLKAIRRSIHLCMVSIRRATFSCAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6T7</accession>
    <name>A0A132B6T7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DEAD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_789352</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062475.1">
        <property type="nucleotide sequence ID" value="XM_018223243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6T7"/>
    <dbReference type="FunCoup" id="A0A132B6T7">
        <property type="interactions" value="1145"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6T7"/>
    <dbReference type="GeneID" id="28832969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789352"/>
    <dbReference type="InParanoid" id="A0A132B6T7"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="97"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="292"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ08120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="54340" checksum="722F88F48721BEF8" modified="2016-05-11" version="1">MLPIKRRKVDEDQPKSLAPSKKKTKHIFKEVVSEPSSPEPEQENVQPQPEGSEVAAEVEGEPEATKSFKDLGIIDSLCDACTALGYKAPTPIQAQSIPLALKGRDLIGLAETGSGKTAAFALPILQALLDKPQALFGLVLAPTRELAYQISQAFEALGALISVRCAVIVGGMDMVPQAIALGKKPHIIVATPGRLLDHLENTKGFSLRSLKYLVMDEADRLLDLDFGPILDKILKVLPRERKTYLFSATISSKVESLQRASLKDPLRVSVSSSKYQTVSTLLQNYVFIPLIHKDTYLVFLLNEFAGRSAIVFTRTVNETQRIAILLRSLGFGAIPLHGQLSQSARLGALNKFRAGSREILVATDVAARGLDIPSVDVVLNYDLPPDSKTYIHRVGRTARAGKAGHAISLVTQYDVEIFKRTEAALKMELKEYKTEKDEVLVFKARVEEAQRHARNEMKNLHEDRGKKGAVLKGRRPKPGDKKRGRDEMDREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B730</accession>
    <name>A0A132B730_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062573.1">
        <property type="nucleotide sequence ID" value="XM_018220784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B730"/>
    <dbReference type="GeneID" id="28830510"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742060"/>
    <dbReference type="InParanoid" id="A0A132B730"/>
    <dbReference type="OrthoDB" id="3525097at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287945" evidence="1">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="275" mass="30875" checksum="B8FB0D0E2B752EEC" modified="2016-05-11" version="1">MAVMRAASTKLSATMIGWLLLSVLPCLSAKALFPCVGCVSEHFLQSETYGIDLASDHIAVAVQHVNGTLEPIALTTPGPRYRSLMNKILMESDMHPYGYGNETPKPFKSCTRDPGDNADIDILAEEITKIATVMQGQNRNIVHYVVSTPISFTHEKYARLRLAFKESNLPQPTFAEPADFAAFTALNTTICDRHFELFCAPIDYNSRTIMFFQYDNSTMSVLLYHFWGGWYFDRVAYFSDGRLGHQNHGDEGHWLAISERITTLIEGNKDKISYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7C9</accession>
    <name>A0A132B7C9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062670.1">
        <property type="nucleotide sequence ID" value="XM_018220796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7C9"/>
    <dbReference type="GeneID" id="28830522"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742153"/>
    <dbReference type="InParanoid" id="A0A132B7C9"/>
    <dbReference type="OrthoDB" id="3754585at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="443" mass="48639" checksum="F2145AF580A21B26" modified="2016-05-11" version="1">MSDSGGCTLTPQARAFSSILSAFIGSVVNGLTSGYMIAFITGWIAWFAFFRVVIGGSYMFYRSVTGTWTVEQSVDQYEIPNRATSPDPESDAQASLINRGSNNQLYENPARNASTTHPPILSELPLSSAEEYLRTVYTTVFTQDTSLAHLPKQSPLSTFWPTRSDLLIRQQTTRLAQQKRSELRTHFASTQDLERALRAYPRLYKQGKLSGLPPPLMSPYLAPLNRDVTVLGWIGWVYSAVYAPISQIIWIAANASTSSSSSGIAKIVKGISVAVTALPLCLDSRVRFADSLQKKKRFGGTWAYYAFNLTNAASCTLQGLLCGALLVWGVVEARSDTDPFFASSFPWPLVAIYPIFSLVWAFGSFRIVPMMDGGRKRASQAHWAGYFLDVGMGVFAGLFLAAPAFALYFSSVEPGMGEEGARDLGQFLECEVPGWQKFSAIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7N5</accession>
    <name>A0A132B7N5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_676838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062773.1">
        <property type="nucleotide sequence ID" value="XM_018213635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7N5"/>
    <dbReference type="STRING" id="149040.A0A132B7N5"/>
    <dbReference type="GeneID" id="28823361"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676838"/>
    <dbReference type="InParanoid" id="A0A132B7N5"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="57168" checksum="5A49E27D17C2B58E" modified="2016-05-11" version="1">MTFASEFEILCSELSILWLRFKLWGQSIGLDLDLFNDIQSTLSSLPDVQSTIVQGVGNIVHLMTEIESIRYKYEFRPPLISDATQPNEKALLRSTISLSALSNTRAIKSLQQRIRDNQRQKSYFTIVKWTICDAKKFEDKVKQLKILIDGLEDVSLAAKVTHQLPAAVTSEDPDPPPYSVTLSQQSASSSNTQATIPSPDQISPPIHSQPSMPSPDSILLHDPEVAAHYTAMLQHCALPSGPQNQPRCRARDKMTRLSDRQFKELRTDVYDELFRRQFEGSTPSSLQKDIRYHPKRNQAREKLSTLPSHRFKDLVVDVLFELERRFPALQGSTSPGVSVLLMSSFSAPSLELCGTQRSSIPPPPLQDRATHPSTLPPTTPSPDPSPLLSRYSQRPSEISEQQSQIEGGGGAASRGSAEIFKSFRVSMTDPTWKVLPAALRKYNIEASADEYSLYVMYGDVERLMGLDEQPLVVFKELDRKGLKPMFMLRKLKGCEVIEPGKSRVVDSDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7S2</accession>
    <name>A0A132B7S2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_599683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062800.1">
        <property type="nucleotide sequence ID" value="XM_018210111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7S2"/>
    <dbReference type="GeneID" id="28819837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599683"/>
    <dbReference type="InParanoid" id="A0A132B7S2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="498" mass="52211" checksum="3154DE047F7F1FE8" modified="2016-05-11" version="1">MLASAQSVQPSNATLPTSESGSETVLSLTGGPIFTGQTYNIAPLTAEVGKGQTPTAVANVKISGTFKQADYSSTGGVDGSDIAFISCDPNGSNIDPSTVVGTVGDQKPGAIVLYSLGAEECTLNGSYSFTSIFTMISSKDSNTLMTTVGLYPSQTSILTANISVNSTTTSQSSSSSSSANEGGPAPTTAVAMSILYSITGIITLLFLVIIATGAVRAHRHPERYGPRTGFPGRPRQSRAKGLARAMLETLPIVKFGDPEPVKPGTNDIEMGGDQTTTTTTTHTAPEVVATSGNTERAKSPTTVATAVESGMGPAQAESVKSGEENAAPKEGELGCSICTEDFTTGEDVRVLPCNHKYHPACIDPWLLNVSGTCPLCRHDLRPATSATAENETETAGDNAEGAEGGELPPPLAIDGETTTAENESTHQRSRASRLLDPNRLRHAPADERIAALRRLREQSQTEGEGEHADSEEPSRRARLTGRLRDAFRIKTRTQDTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8L1</accession>
    <name>A0A132B8L1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_599061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063105.1">
        <property type="nucleotide sequence ID" value="XM_018210070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8L1"/>
    <dbReference type="GeneID" id="28819796"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599061"/>
    <dbReference type="InParanoid" id="A0A132B8L1"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="39382" checksum="AB352D5D952AD6B1" modified="2016-05-11" version="1">MAVEGDAENQTNVNEETPLLPEQQQQQQQQQQLDQQSNEEDDEEPKRTSQTSWYLWRIFWFIVAALVLAVFIKGWIDAGGDFDLKRTLMRALGGGLSGAAAMVLQVLLLMPLRTIMNYQYRFGTSFTAATRTLYQDGGLGRYYQGIGAALIQGPVSRFGDTAANAGILALLQSNSYLKNLPSPIKTIFASLCAAAFRMILTPIDTLKTTLQVQGASGTALLRQRIKTNGIGSLWWGAIATAAATFVGHYPWFATYNFLMENIPEPPHHPLIVWLLRLAFIGFVASIVSDSVSNSLRVLKTYRQVNDSKVSYSEAARLVILEDGITGLLGRGLKTRILCNGLQGLLFSILWKLFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B903</accession>
    <name>A0A132B903_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like f-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_328663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063245.1">
        <property type="nucleotide sequence ID" value="XM_018206769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B903"/>
    <dbReference type="GeneID" id="28816495"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_328663"/>
    <dbReference type="InParanoid" id="A0A132B903"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288004" description="Cyclin-like f-box protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="34667" checksum="5DADCC6F21BEFC40" modified="2016-05-11" version="1">MQESWSRFLSFALLFVFALQAEALPKKKATSGTGTNVAAAAAPSASGGITTATDGSTILDKTVQINGLSIRYKISAPADQFTAASGVTGASATANTTGTAGLNVLLHGDGGQSFFDFPNQAVQNNLMGVVVLAPNKNLFWGGGSGLQRTDGVAHAAAVNSLIQNQLSQDVAFDPGNVFFTGVSGGSLLLSGFFVPAFGAQYKTGVVLNCGALVPQVNVTDANTLATSMKIHFQSTKDELALLQPAIPKAIAAYEKIATTVGMSAAQIGTMQTVDNTPNGGGHCGFDGTGFVKGVQLMSTNFANIMGQNASGEVSGIGNVLTTVFGNENVVFTSAGQAQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9B4</accession>
    <name>A0A132B9B4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_599942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062622.1">
        <property type="nucleotide sequence ID" value="XM_018210125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9B4"/>
    <dbReference type="GeneID" id="28819851"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599942"/>
    <dbReference type="InParanoid" id="A0A132B9B4"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF2">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="28166" checksum="837F79680BA7ABB4" modified="2016-05-11" version="1" fragment="single">LLKDYSSVAPEDVSQHVHNIRDKAWAIRPYPCTGMGNFLDSMLAKSVAYPTIIARLKAGDSLLDIGCYLGQDLRRLVLDGAPATNLYGVDIVNYWDLGYEMFRNGDKLSAKFMEGNVLHLSTDLEELVGKVDILSVTHVLHQWEWEGQVAAAKELSLLVRPGGMVVGFQVGTAGGKSKQDWDGGRKTHDWMKQDAESWRRMWALIGETTGTKWSVDTAQLRTFEELGHDPKEVTYLGRDARILKFIVTRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9C3</accession>
    <name>A0A132B9C3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_659049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062954.1">
        <property type="nucleotide sequence ID" value="XM_018212502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9C3"/>
    <dbReference type="STRING" id="149040.A0A132B9C3"/>
    <dbReference type="GeneID" id="28822228"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659049"/>
    <dbReference type="InParanoid" id="A0A132B9C3"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="620"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="717" mass="79402" checksum="FE494C7DF6621735" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAP1</accession>
    <name>A0A132BAP1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetoacetate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_314334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063279.1">
        <property type="nucleotide sequence ID" value="XM_018206663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAP1"/>
    <dbReference type="STRING" id="149040.A0A132BAP1"/>
    <dbReference type="GeneID" id="28816389"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_314334"/>
    <dbReference type="InParanoid" id="A0A132BAP1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="695" mass="76112" checksum="1885C3901068D6E8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBK6</accession>
    <name>A0A132BBK6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_701327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063579.1">
        <property type="nucleotide sequence ID" value="XM_018217188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBK6"/>
    <dbReference type="STRING" id="149040.A0A132BBK6"/>
    <dbReference type="GeneID" id="28826914"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701327"/>
    <dbReference type="InParanoid" id="A0A132BBK6"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="87"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="437"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ09224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="487" mass="54040" checksum="DC75E2DD25AF777B" modified="2016-05-11" version="1">MASALFRLLYITVLDPPYLPLGPAALRSRRGFSTSEKEKSTSDADGIGGAEYNVGFREGTGGPLDPDSPGLEYFYTKEVFSSEVDGKPKWCSHCANWKPDRTHHCSDAGRCILKMDHFCPWVGGPVGETNFKFFIQYTGYTALYCLHLLVVMAVYIGRQVNTEGETYNPQFTAILGLATFFFLFTAGMTGTSMDLAMNNLTQVERLGAKTRVHTLAILKPSIEQLHHISPTVAGQHNYREITFPLPLTKPPTSADFSTSTSNASNSPLARVEVEGNVPEEEVRSLGSQPALGTSSEPSQGSSTVPVKASTNNDHNERVLDTPGRLNPTAEPRTEIEVITPASANAFAQSRPSNRDLMATRTFAVLDLKQGHNPWDLGTRLLNWETVMGSSVIDWVLPIKRSPCCNHEDTESQFQLGPWVDILKSSYGFLSPEDMRAYGGRRKSERRDVEDFKPRSGHRKRRRRQKRDTGRELPVQLDDLESQAPQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBN6</accession>
    <name>A0A132BBN6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_690201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064143.1">
        <property type="nucleotide sequence ID" value="XM_018216050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBN6"/>
    <dbReference type="STRING" id="149040.A0A132BBN6"/>
    <dbReference type="GeneID" id="28825776"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690201"/>
    <dbReference type="InParanoid" id="A0A132BBN6"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="143" mass="15963" checksum="D42A01E95436D420" modified="2016-05-11" version="1">MPSSCKDIRTSLSLPLFLTNSKAKNNTGAALAQCLQESDCVMVYRNKPGDCLREPLIDSMPTKCQQLKKGLGECKRGMVDMRKRFRGNQPIAVSKELEGGAQEPSHQLYAGRPAFSGTVKSTSGDEPPERDWREVENEKFRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBZ5</accession>
    <name>A0A132BBZ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_675428</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064271.1">
        <property type="nucleotide sequence ID" value="XM_018213506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBZ5"/>
    <dbReference type="FunCoup" id="A0A132BBZ5">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BBZ5"/>
    <dbReference type="GeneID" id="28823232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675428"/>
    <dbReference type="InParanoid" id="A0A132BBZ5"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="16" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="825"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="712"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ09916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1256" mass="141597" checksum="096AFA26BE30B97D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCL6</accession>
    <name>A0A132BCL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_596982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064348.1">
        <property type="nucleotide sequence ID" value="XM_018209956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCL6"/>
    <dbReference type="GeneID" id="28819682"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596982"/>
    <dbReference type="InParanoid" id="A0A132BCL6"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="142" mass="14925" checksum="6D838A36DE1B3BBD" modified="2016-05-11" version="1">MTTKGSCMCGAVEYEFTGEPAVTALCHCTDCQKWSGGAYTSNVVVPRTNMKVTKGNTPVVGALKTYDAVGNSGKINKHFFCGTCGSSLYTELEVMPDVACIKAGGLDGGKADLGQVGVEFYTKDRVSFAKAIDGAKQEKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDA7</accession>
    <name>A0A132BDA7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_259734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064741.1">
        <property type="nucleotide sequence ID" value="XM_018206266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDA7"/>
    <dbReference type="STRING" id="149040.A0A132BDA7"/>
    <dbReference type="GeneID" id="28815992"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_259734"/>
    <dbReference type="InParanoid" id="A0A132BDA7"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="19061" checksum="F13EF7A6F494B314" modified="2016-05-11" version="1">MIKSLHIYGDNPRYAMIEQRHDDTFHWIWNNREDGGPGFVEWLEGEDGLYLISGKPGAGKSTLCKYIESCESTMNLLQSNTSSRTFLMSFFFWDLGQESEKTFSGLLHNLLSQLLVQIPELVPAVLGRFQRLNKHVSVSANRSSIWNDSELQSAFKDILQLRVSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDQ2</accession>
    <name>A0A132BDQ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_656387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064905.1">
        <property type="nucleotide sequence ID" value="XM_018212382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDQ2"/>
    <dbReference type="STRING" id="149040.A0A132BDQ2"/>
    <dbReference type="GeneID" id="28822108"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656387"/>
    <dbReference type="InParanoid" id="A0A132BDQ2"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="29448" checksum="D9A48C0C971382A0" modified="2016-05-11" version="1">MSFTTPPPPILDSQISFPTPSILLITLNRPKDLNCINTLGHHQLDALLRWYDREPALLCAILTGTGRAFCAGADLKEWNRANAESKSRPQPSSGFGGLSRRNGKKPVICAVNGICFGGGCEMIINADMVIADQGAQFALPEVKIGVVALAGALTRLTRTVGRQRAMEMALTGRTVSAEEAREWGIVNKVVEKGRCVEEAIRMAGLVAANSPDSVIVSREGVKMGWEGVGAEEGTRLVIENWYSRMDGGENMKEGVRSFVEKRKPRWVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDU2</accession>
    <name>A0A132BDU2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_690233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064192.1">
        <property type="nucleotide sequence ID" value="XM_018216056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDU2"/>
    <dbReference type="GeneID" id="28825782"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690233"/>
    <dbReference type="InParanoid" id="A0A132BDU2"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31362" checksum="6C7E0FFD01E5D6A3" modified="2016-05-11" version="1">MAPQTSIPVAANVLGTIGTGCWCVQLIPQIWTNYRTKNTEGLPGIMMFLWAICAVPFGAYSITQNFNIPIQVQPQCFGTFCLISWAQTLIYHDKWPVWKASTLGFVVWALFGGAEAALILTLRPLYDRGIDFPMIILGVIASILLALGLLPPYLEIWKRRGRVIGINWIFLTIDWSGAFFSLMALVAQNTFDVLGGVLYIICVILEAGIFVCHLIWMFRTRKIRAHAKSEGKTFDDIAKECEEQDGEFKFAEREIKIHGRRKKDDASKVSLGDVEVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEN7</accession>
    <name>A0A132BEN7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_740042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064669.1">
        <property type="nucleotide sequence ID" value="XM_018220541.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BEN7"/>
    <dbReference type="GeneID" id="28830267"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740042"/>
    <dbReference type="InParanoid" id="A0A132BEN7"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="2">
        <location>
            <begin position="60"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="3">
        <location>
            <begin position="553"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1359" mass="151851" checksum="D3864897CB85F3CD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BFN5</accession>
    <name>A0A132BFN5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-type alcohol dehydrogenase-like protein C16A3.02c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064882.1">
        <property type="nucleotide sequence ID" value="XM_018215962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BFN5"/>
    <dbReference type="FunCoup" id="A0A132BFN5">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BFN5"/>
    <dbReference type="GeneID" id="28825688"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689739"/>
    <dbReference type="InParanoid" id="A0A132BFN5"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="37496" checksum="7004CC356151653D" modified="2016-05-11" version="1">MAKTFSPSVSTMKAWQYTTTKGGLEKNLKLNPSTPLPTPTPNQHLIQIIGVALNPVDYKLCELPLVTRFLVSKPATPCVDFAGCIVTPASGSDFKPGQLVFGVSGSSPLSGGALREFNVAGLGNVVAVPEGVDPLHACGVGVAGLTAYQSIVPRVKKGGRVFINGGSGGVGAFGIQIAKVVGCHVTTTCSTRNVDLCKSLGADEVVDYTKGSIVQFFREKGWKFDHVVDNVGSNEELVWKCGDFLNPGVVFIKVSGDLSLHGMIDGFKRKVVPGALGGVKGKVEGFWPKPKAEDLDQIAEWMKEGKVKAVIDHTFSFEEAPKAFEKLKTGRARGKIVVDVASKTYTKAWETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSW2</accession>
    <name>A0A194WSW2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065062.1">
        <property type="nucleotide sequence ID" value="XM_018220492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSW2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="26804" checksum="902F2B77F109EE50" modified="2016-10-05" version="1">MNFTTTPGSITALRYLLALLPIEDMTTNDDNLIFNDTFLKATKIQDPVFICLDTEGDSAREFGMRAEFERPFQFGISRMIGAGSVFPLLQNIFRTGHPDSSHQESRNTILVGHSVDGDIASLEKVIGRAWSIQDFPYSLVFDTQVTRRGLFGGPAHKRLETQLIKLQISYKYLHNGGNDSNFTLKALLALALLDCPVNKDCSLELRKRKKIIRAIAQMPMPPRIADHLEPIPLDSVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT17</accession>
    <name>A0A194WT17_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_689418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065169.1">
        <property type="nucleotide sequence ID" value="XM_018215905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT17"/>
    <dbReference type="GeneID" id="28825631"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689418"/>
    <dbReference type="InParanoid" id="A0A194WT17"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="30367" checksum="2B09DB0716F1FA1F" modified="2016-10-05" version="1">MAPSNFPGPVTLYTIGYAALKYPSLPPAPVNVPLGDQVGLLQHQLPHAQNHQIAQLASQYLNALLTYQTSSDPALHDPSTPQYYFSTAICLLNFLNTSPDVCKRIASHPTLLHDVVEKLLANDVVEKMKAVPRPGGANFPAATFDDDFGSLLQFLSTVLLYIDDPSSVHERFQDLIPKLRAWKREFRGSRVRTISNAADRLVGQIQGTDATMLKLIRGMQDSSLVCGVQSCGVRGAAGLTVCGTCKIQRYCGREHQKADWKFHKHICDKGLVEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTM8</accession>
    <name>A0A194WTM8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_541181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065322.1">
        <property type="nucleotide sequence ID" value="XM_018208181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTM8"/>
    <dbReference type="STRING" id="149040.A0A194WTM8"/>
    <dbReference type="GeneID" id="28817907"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541181"/>
    <dbReference type="InParanoid" id="A0A194WTM8"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="93260" checksum="6E32306C617C0383" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUE4</accession>
    <name>A0A194WUE4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065936.1">
        <property type="nucleotide sequence ID" value="XM_018215773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUE4"/>
    <dbReference type="GeneID" id="28825499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688788"/>
    <dbReference type="InParanoid" id="A0A194WUE4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="31204" checksum="9A79D67612AA4CA7" modified="2016-10-05" version="1">MEFKPTHATVENEGCNLHYYFYGTGPLITFIPGGNGHGLQYNAIMELMSPTFTCVTFDRRQMSNSQVEKSKPLSHPQQARDVAAIIKAMGFSKSIIFGSSLGGVIAFQFGIDFPDMVDRIVCHEAPTSSLLPNSTEVYNKLYTCEQLYRTVGIQAAQQEFRKFFIGYDDVGVPPTRSDPRNEPSFWEYEFWTASIYTPDLRKLVKNGTSIAVMAGERSKDAWFSVATEEQAAILGCERVVVPGHHQGFEAETELFLPPFLSLLERMELEKKEKTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUK7</accession>
    <name>A0A194WUK7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_228580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065990.1">
        <property type="nucleotide sequence ID" value="XM_018206019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUK7"/>
    <dbReference type="GeneID" id="28815745"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_228580"/>
    <dbReference type="InParanoid" id="A0A194WUK7"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267469" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="21062" checksum="102F541081377657" modified="2016-10-05" version="1">MRSLILSSLAALAVGSSASVMQPRNVANNNCGRAVAGTAKGTAFMSSARADCSSNVISYTTVTVTPLATTLTQGVDVQSTAVATSIETDAESTTGTSTILSTEVDQYVSTAYSTSIEIESLTVPTTTTPPVITATSVITVTSSSVSTVTSYYPTAAAVAKRDLEDTEFEDCEIEERDASSTITASLTIPAYASACTNWAEYVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUU1</accession>
    <name>A0A194WUU1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_230422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066075.1">
        <property type="nucleotide sequence ID" value="XM_018206033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUU1"/>
    <dbReference type="FunCoup" id="A0A194WUU1">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WUU1"/>
    <dbReference type="GeneID" id="28815759"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_230422"/>
    <dbReference type="InParanoid" id="A0A194WUU1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903329">
        <property type="term" value="P:regulation of iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="251"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="59503" checksum="AAC29DC45B091E0F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUU4</accession>
    <name>A0A194WUU4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_688893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066080.1">
        <property type="nucleotide sequence ID" value="XM_018215800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUU4"/>
    <dbReference type="STRING" id="149040.A0A194WUU4"/>
    <dbReference type="GeneID" id="28825526"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688893"/>
    <dbReference type="InParanoid" id="A0A194WUU4"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="64"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="27718" checksum="3038B216DFB5D3E0" modified="2016-10-05" version="1">MPTACPATTTKMPSLELIHDHMAVTHAKKASVTVTIAPAPDSGIEPTLLTLRPELTYPPPLRFYFAYGSNLSLTQMSRRCPTATYHSFGILRNHTWKIGPRGYANVVPTSASCSPSSTLQKSSGAHKPVVYGALYTLEASDEEALDYAEGVPFAYEKRDLFIEVLSVADSSSCEVRVGQMVKALVYVDVKRTGEGVCREEYCGRMNRSIRDARKMGMPEWYIRDVMRKGVREEEICEDMPDPFHPGILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVI8</accession>
    <name>A0A194WVI8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_739039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065967.1">
        <property type="nucleotide sequence ID" value="XM_018220433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVI8"/>
    <dbReference type="STRING" id="149040.A0A194WVI8"/>
    <dbReference type="GeneID" id="28830159"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739039"/>
    <dbReference type="InParanoid" id="A0A194WVI8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13575" checksum="6F0E58535509F3BE" modified="2016-10-05" version="1">MAAALAHTHFVAHTYHMDIKPANFLIDADFHLVLIDWERSGVPAAVTAPEVDGTWDVEEVSAEGSSTPRYTKYTGPETRNTSLSSTPGVYPEWSKKCPKALELAEVFSLGRCMWKLLRQPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVQ4</accession>
    <name>A0A194WVQ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tcp11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_220314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066406.1">
        <property type="nucleotide sequence ID" value="XM_018205937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVQ4"/>
    <dbReference type="GeneID" id="28815663"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_220314"/>
    <dbReference type="InParanoid" id="A0A194WVQ4"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="666" mass="74625" checksum="C7C178A53559E24E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWD4</accession>
    <name>A0A194WWD4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_652694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066641.1">
        <property type="nucleotide sequence ID" value="XM_018212212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWD4"/>
    <dbReference type="STRING" id="149040.A0A194WWD4"/>
    <dbReference type="GeneID" id="28821938"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652694"/>
    <dbReference type="InParanoid" id="A0A194WWD4"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="6">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="477" mass="51452" checksum="3036CF0B754314F1" modified="2016-10-05" version="1">MSPSRTSQNGTENQQFGDLNLSITGIGTEYPLVLLEPSCVDILCQRHYPDSPAMQKIRAINQYTGIDTRSSIGTVDHPMANMDRAPTIAELCSIFLKDGVALAVTAARKALHEARLSPLDITHVVSTTCTNSANPGFDHYVCKQLGVTQPVEKVLLHGIGCSGGLASLRTAANLALGSSFRGKKARILVVALEISSLLVRSELDSIHELQQTRIGVTLFSDCASACILSNGIGGEEAEPVYELLGWDHRMIPDTEEDLGFDVHPSGWKVVLSPRVPKLASAVVKPTFTDLLSTLPNLPPTYKSAADFDWALHPGGATILSGVERAMEITPEHMRASYDTYIKHGNSSSATILSVMDRLRQKDMDEIASGGKVKDFVVGCAFGPGIAVEMCMLKRNMSHVRRVLEGVSGEVTPPETESEGSRSEGEPEIDFRPEELEGEIRSVKEQEAALSETLNAVHPEVPEQGDSLAEALNGVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWK0</accession>
    <name>A0A194WWK0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_688532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066414.1">
        <property type="nucleotide sequence ID" value="XM_018215726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWK0"/>
    <dbReference type="STRING" id="149040.A0A194WWK0"/>
    <dbReference type="GeneID" id="28825452"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688532"/>
    <dbReference type="InParanoid" id="A0A194WWK0"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
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        </location>
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        </location>
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        </location>
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            <end position="412"/>
        </location>
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        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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    </gene>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <end position="24"/>
        </location>
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            <end position="597"/>
        </location>
    </feature>
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            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="62713" checksum="BA69CAB58198086D" modified="2016-10-05" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
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            <begin position="59"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="599"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12389.1"/>
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        <source>
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    </evidence>
    <sequence length="655" mass="72265" checksum="A41463739A8C1CA7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYM3</accession>
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            <taxon>Mollisia</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="38438" checksum="5E568DCAD9B54A68" modified="2016-10-05" version="1">MSNSQISTNKSFTVAKSGNNYAYIHHPPSNPSKPTVLFLHGFPSTAHDWRHQVPYLTSLGYGVLAPDLLGYGSSSKPLDVEPYIGSSMAADIVSLLDYEGIRTVVGVGHDWGTYLLSQLIIWFPERVERCVFVSVPFHVPGRKTDAKAVNDKSKKALGFELLGYWMFLTAPGAGRTIGDNWEVFYDLVYCADASLWKTHWAGLGAMESTLKTLTPSSSSKHLAPWTTPSDKTHHHNSFGNDYSPTLNWYHRGISSLGVDAEISALKEGKISSKIDIPTLMIGGTKDVVCDATHARKVMQSSVEREKLKVVDLETGHWINLEEKEKFNEVLREWLEETSGEGGARPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYY0</accession>
    <name>A0A194WYY0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_784932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067526.1">
        <property type="nucleotide sequence ID" value="XM_018222834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYY0"/>
    <dbReference type="GeneID" id="28832560"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784932"/>
    <dbReference type="InParanoid" id="A0A194WYY0"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="57911" checksum="9CD9B5960B40A5D1" modified="2016-10-05" version="1">MWPAPGVHQRRVDSDAPPQKHIFSRSHTIPIVCFKLETHLQLQKATRALTIMPTMDPLQLFDLMMDETDQTTFLQLFSSFCRHSSNDAVALKPSSWFKRESILPPLPEVWRNTAADVLAQATFTNIKVDNLRESSLQLLRPGNMLDHELVEAYIGLIRQEGASICSTRLFDSIELGTPQQTTDLLIDYQQVCHRVGSLHLEQAEADEIVPSFRYRILAELLAGTLDPSVTEHERFVSQTVRDQSAETADDTRDLIPKGSLDEDSISVDSTQPRSSQLRKEKHDGSSFVDTCVKSFASEKSMLEILNLAVRFHRVTKPDVITDQGLDFLYHKVENDDHAQDILRNRHYREQYSRMFYRSLKQIGGTSFRADNWVRAAMQQIMRLPPDTKLWKAAQSHASRSTVWAELLDIFQGHLDFPCTALCGTCESTAAIEGLSRKSRDLFFLGLRHRLQDPADGMLKNLKAASALARALLYNHLPDFTLAIERKTDLDLMDFEAAVSVEEKLRLPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ21</accession>
    <name>A0A194WZ21_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_785495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067304.1">
        <property type="nucleotide sequence ID" value="XM_018222898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ21"/>
    <dbReference type="STRING" id="149040.A0A194WZ21"/>
    <dbReference type="GeneID" id="28832624"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785495"/>
    <dbReference type="InParanoid" id="A0A194WZ21"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="175" mass="19190" checksum="8CBD198A730386B9" modified="2016-10-05" version="1">MAATFDKTKSNFPLAGIARDGWSTEDEATATCFCGAVQLSFPTQGEGLVDTFICNCADCRKITASMFVSNFTIADTHLKHVRGQDNLKVFKQTYTVGGGNTSRTMANHFCSTCGTLMYRVGSAFPGMSILRIGTVDDFHLHESKLFPQYEQFTKSRVSWLHGVEGVKQVEGSYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X187</accession>
    <name>A0A194X187_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_753348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068316.1">
        <property type="nucleotide sequence ID" value="XM_018221274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X187"/>
    <dbReference type="STRING" id="149040.A0A194X187"/>
    <dbReference type="GeneID" id="28831000"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753348"/>
    <dbReference type="InParanoid" id="A0A194X187"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="37686" checksum="8A050AE5F17C1367" modified="2016-10-05" version="1">MAGGNALIPLKYMAENPGQLVRTVPCGMYHNESHKFRSRLGLEFASPIEISDNIAALYKAGQQNEAIPSLRKLVGVALHNMTLSHSNNGFDKIVDIMESLYGGSNARLHQKSQRNKELWRLYLQFESDPNFQRILYRMYQYQRRINLLGVESEDIGGASKSYILLLLLGLRFLELALAAVLRLPGLILFGPLPYLCNNLAQRYAERLLKNSAFKLTGRDVLASAKMLNALKFTTLLYIASETAMFAWLHWNYLGQSLVRVIPAPFAVVLGLTLISFIRVVSIWAWDRTVDVLRSILVLLILADPRKACMRESLEGEKRELEVHMWQYIVSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1Z8</accession>
    <name>A0A194X1Z8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_149027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068222.1">
        <property type="nucleotide sequence ID" value="XM_018205382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1Z8"/>
    <dbReference type="GeneID" id="28815108"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_149027"/>
    <dbReference type="InParanoid" id="A0A194X1Z8"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28129" checksum="0855F2A85A25803B" modified="2016-10-05" version="1">MPPNKRCLLWDWTNTRDCPEKIFQIPIPGPITSVANWNTWQPPELPPSIPFRPTIRTPAQLSGQDWSNILSSPSPIIHYLNEPERSGVTPSEAAELWFEKIVPLMKEKGIKVVGPSCASDAPGLAWLESFMSLLKAKGEEPDFLGLHYYGPEPEAAIRYLEEMHGRWPAMKVVVSEIACTSREYRAVVEFTGKLCNWMDEREWVVEYAFFGCVREVVDAFVSPEAQLMGKDGGLTELGVRYMGECPWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X266</accession>
    <name>A0A194X266_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_736308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068618.1">
        <property type="nucleotide sequence ID" value="XM_018220107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X266"/>
    <dbReference type="FunCoup" id="A0A194X266">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X266"/>
    <dbReference type="GeneID" id="28829833"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736308"/>
    <dbReference type="InParanoid" id="A0A194X266"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="865" mass="98252" checksum="E22C3D5D67984BC9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2J2</accession>
    <name>A0A194X2J2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_650202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068761.1">
        <property type="nucleotide sequence ID" value="XM_018212097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2J2"/>
    <dbReference type="FunCoup" id="A0A194X2J2">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="GeneID" id="28821823"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650202"/>
    <dbReference type="InParanoid" id="A0A194X2J2"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990616">
        <property type="term" value="P:magnesium ion export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="263"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="45009" checksum="D4FEB5586EA49F97" modified="2016-10-05" version="1">MSLGSRVASLFSGSTNTQQGREKLDFVDDGLPAGKQTFADVNLGIPGLGSDTMASQTDEEEGRPPYLHSMIAGGLGGTTGDLLMHSLDTVKTRQQGDPHIPPRYTSMSSSYGTILRQEGLRRGLYGGWLPALLGSFPGTVIFFGTYEYSKRHMIDAGITPQFAYLSSGFVADFAASFIYVPSEVLKTRLQLQGRYNNPFFQSGYNYKSTSHAARTIIRQEGFFALFYGYKATIFRDLPFSALQFAFYEQGQNWARQWKKSRDIGLPLELLTGAAAGGLAGVITCPLDVVKTRIQTQVNPAARATFQKTPQNCSSTKTDSSPIKQQIRSISTSSPSTHTPRPGSIKLDTSSVFTGLKVIYRTEGFAGWFRGVGPRFVWTSVQSGCMLFLYQTILRKLEIYAASKEDLESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2L8</accession>
    <name>A0A194X2L8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_686902</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068783.1">
        <property type="nucleotide sequence ID" value="XM_018215388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2L8"/>
    <dbReference type="STRING" id="149040.A0A194X2L8"/>
    <dbReference type="GeneID" id="28825114"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686902"/>
    <dbReference type="InParanoid" id="A0A194X2L8"/>
    <dbReference type="OrthoDB" id="3468995at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="31"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="318" mass="35513" checksum="11628E93EE619D23" modified="2016-10-05" version="1">MGDPGPITPDSFNDGRQQISQPFRLTATGYNLNYLPEYIALRHGFFQEQGLHVTVNIPVPWDGVLDALADGTADMALGGIWVPSMYRDRVQNYTVFAQIANRCPLALLRRGHDDGFKLQDMVGKTVLMKSGGGASVGLFFKMLMRENDIDPRSLDYIQDLDGVMLGNLFQGGMGDYFVTDNLSALAMVDRNPNVSIAMEMVEQEDVPWSVYYRETATITPEVIDAQNRFCVALGKGIDWVLQHDAESFRDELAELFPTVPVDVAVKVTNAFRRNGMWTTTTVPREGFNRWQLGLRDARLVKEPLAYESIVHDGIAVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3U4</accession>
    <name>A0A194X3U4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_123828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069196.1">
        <property type="nucleotide sequence ID" value="XM_018205178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3U4"/>
    <dbReference type="FunCoup" id="A0A194X3U4">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3U4"/>
    <dbReference type="GeneID" id="28814904"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_123828"/>
    <dbReference type="InParanoid" id="A0A194X3U4"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="326" mass="35409" checksum="80AD81A88C76FEB3" modified="2016-10-05" version="1">MHRGASQSLSHLTNDVLLPTMTTRIPILLLKTRSSPTDGYEDQFSTPQHGLTFSPTFVPVLEHQLLDDGMNTFRNLLERKEIGEGQGKKYGGLIFTSQRAVEAFAQLVAEGRLNDPSYPHLAPSTPIYTVGPATSRALSALSTPSSPLTILGQETGNGEALAQYILSHYPSDSKSKFKSRLPLLFLVGEQRRDIIPKTLSSPSLEASNRIAVDEITIYGTGIMASFERDFKAVLKRTENVGRRWVVVFSPTGCEAMLRALGCLGDARGKAGGERDGKTFVASIGPTTRDFLRAEFGFEVDVCAERPSPEGVLEGIWGFMEGLGGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X497</accession>
    <name>A0A194X497_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_784033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069351.1">
        <property type="nucleotide sequence ID" value="XM_018222745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X497"/>
    <dbReference type="GeneID" id="28832471"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784033"/>
    <dbReference type="InParanoid" id="A0A194X497"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="331" mass="35096" checksum="ADB5C5256EE89A9E" modified="2016-10-05" version="1">MSDARTRHENARAEGESTSQANCENVGVLNHHPLTHITNLYGNYVANNPPAASTSRLISSSRERSQSRDNGSTIPSNNERAIPLEEFNTSHSPIRAADKSLEDRWRVRDLPWSWRRHPKFCIATGLFVLVIVGAVLIVLHFTVWDKHSSLSTVSETASHTLPTSTSSFISTQPKSQANTSLNSSATVSKSSMSLQELDNTATDSASTLSSSLTKTNSLITTEGSSTTKSAALSSTCTPNCLSPSTTSSTIPSTTTHIPITFVPSTTSTKTSNSQVRCTVDSDCPSPSACEYSASTCFICTYATSGAPCNTASGCCDPFSCIGGTCISISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4J8</accession>
    <name>A0A194X4J8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_649772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069460.1">
        <property type="nucleotide sequence ID" value="XM_018212080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4J8"/>
    <dbReference type="FunCoup" id="A0A194X4J8">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X4J8"/>
    <dbReference type="GeneID" id="28821806"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649772"/>
    <dbReference type="InParanoid" id="A0A194X4J8"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13322" checksum="23E343A024D7ED28" modified="2016-10-05" version="1">MGFFSSSAPSPPAPRISADGAPIAPGRSERAKCWEARDAYFECLDKNSIVDSITDKDKAAKACSAEGRGFEANCASSWHQVTYFKKRRVMEYQRNKTLEKLKAEGAQEMPGQIGPPGPGQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4V2</accession>
    <name>A0A194X4V2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_686650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069454.1">
        <property type="nucleotide sequence ID" value="XM_018215333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4V2"/>
    <dbReference type="GeneID" id="28825059"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686650"/>
    <dbReference type="InParanoid" id="A0A194X4V2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="73" mass="7974" checksum="B58BE548C0EA7688" modified="2016-10-05" version="1">MGRCGYFATQDNDRQLSGTVRGALSLFRSQGYIFTLPTERIGIGSGNAMWCVLYFILPLLGQDPAGLLSQMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X570</accession>
    <name>A0A194X570_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_648574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069681.1">
        <property type="nucleotide sequence ID" value="XM_018212023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X570"/>
    <dbReference type="FunCoup" id="A0A194X570">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X570"/>
    <dbReference type="GeneID" id="28821749"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648574"/>
    <dbReference type="InParanoid" id="A0A194X570"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="161" mass="18594" checksum="BAB103B3101D202C" modified="2016-10-05" version="1">MKILEAQSATLTNYEVYQHLTEQKRRYSGTKGRRPGNLETVVKELLDYFHEAPSPLASKPFPYHDGVFKALLERLRPWDFTKAEILMIMNLRPTKPENLNTIVEEMEERFPGDELQWEIVSAIAEVLGKPDGEAERQAMSDEAKEARKEQADRRDDVDMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5K2</accession>
    <name>A0A194X5K2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_719925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218533.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28828259"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719925"/>
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    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="715" mass="79476" checksum="549AB3E493EB2A63" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5K8</accession>
    <name>A0A194X5K8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_113348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_113348"/>
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    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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            <begin position="19"/>
            <end position="51"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="628" mass="69651" checksum="62594A4AD2ABE1C2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5V8</accession>
    <name>A0A194X5V8_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">LY89DRAFT_719795</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1535081at2759"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COMT-like"/>
    </dbReference>
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        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="195"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="46018" checksum="435F5AEF545E4233" modified="2016-10-05" version="1">MAAPAPMIPRKDELQTLIAELTNVAADYSASPDLQGYVSRVQVIAKLKDITKSLITVDQLPNYHGLNMAELIALRTFIKLKVFVAIPESGSISLADLSKATGAQESLLERMARILVATGFLDQTRPDGGDYKHTKFSLSYIVTPAPGPAKLFLSMYDEWFKNMHNFDDYLAAHDLLSHATEPDNHLHNPYTWTHKQEGTPVWTIMAQDPEKFATFQVAMSGLDAAIPVIGHFPFSSLATHESKVQLVDVGGGHGAVLKQILSVHPDLDPKQVVLQDRPEVLELARSNGLSVDVQLQAHDFMTEQPVKGARAYFMRMILHDYADPMCVEILGRLAEAMDAESRLLVCEMVIPQWVGELDFPAAVLDQCVLAMGGKERTEAGFKALFEAVGIELVQVWRVPGVPGACVEGRLKGSYLGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X670</accession>
    <name>A0A194X670_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="13 14">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069914.1">
        <property type="nucleotide sequence ID" value="XM_018215249.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X670">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X670"/>
    <dbReference type="GeneID" id="28824975"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686279"/>
    <dbReference type="InParanoid" id="A0A194X670"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="344"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1252"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1494" mass="169539" checksum="2BDB117A737CBFDE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6N6</accession>
    <name>A0A194X6N6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_647855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070188.1">
        <property type="nucleotide sequence ID" value="XM_018211977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6N6"/>
    <dbReference type="STRING" id="149040.A0A194X6N6"/>
    <dbReference type="GeneID" id="28821703"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647855"/>
    <dbReference type="InParanoid" id="A0A194X6N6"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267908" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="37"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="373" mass="40427" checksum="6696C08DE20B104D" modified="2016-10-05" version="1">MWFSKALFLLFAGLTAATPTPVGAGDLLSKASIPAVSGLKFNIDGTTGYFAGTNSYWIGFLTNNADVDLVMTHLKASGLKVLRVWGFNDVTQSTSGVWYQSFISGKTPQINTGANGLQRLDYVVSSAEAHGIKLIVNFVNNWGDYGGMPAYNTFYGTTKTTWYTDAKVQAQYQTYIKAVVSRHINSTAIFAWELANEPRCNGCATSIVTTWATKTSAYIRSLDPNHMITLGDEGFMNGGGDGSYPYTTGEGMDFEANLKIPDISFGTFHLYPTSWSEKDALGFGNGWIKAHGAVCASVGKPCVFEEYGMESNKPAIEGPWQTTALNTSGMGGDMYWQYGDTLSSGKTADDQYTIYYGSSDFTTLVTDHVKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X763</accession>
    <name>A0A194X763_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_670201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070007.1">
        <property type="nucleotide sequence ID" value="XM_018213145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X763"/>
    <dbReference type="STRING" id="149040.A0A194X763"/>
    <dbReference type="GeneID" id="28822871"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670201"/>
    <dbReference type="InParanoid" id="A0A194X763"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="19326" checksum="FD881DE7EC079957" modified="2016-10-05" version="1">MTTIPSIACLGVIGKNNNPLHISIFPSAPTNTPLRTPLQFSLLLASTLDIFEARSKANTTTGGGLSGDFGLLHAVDERLAAYGFETNTGVRFVVVVDMRGRAVSETSKGLGVGGLGLRDGEMKVVFRAMQAAYVKLLQNPFYEPDEHSPPTGRGGKKITSRKFVEEMKKIGDTWMPGVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X836</accession>
    <name>A0A194X836_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_697953</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070322.1">
        <property type="nucleotide sequence ID" value="XM_018216942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X836"/>
    <dbReference type="STRING" id="149040.A0A194X836"/>
    <dbReference type="GeneID" id="28826668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697953"/>
    <dbReference type="InParanoid" id="A0A194X836"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="226"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="426"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ15967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="522" mass="58723" checksum="63A29E9FA8142CB0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X883</accession>
    <name>A0A194X883_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_734432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_734432"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KUJ16324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="37247" checksum="48A86CF886A2EC08" modified="2016-10-05" version="1">MSSSYNDSFRKFCTSYSYSFVFDQKLDNQNAFWEFCFDLLKEFPDDIFTDAGEEEEEVVPQWLLDIRSQWSNKVEKKMACPAKCTLCSWASVHTVEEALAYEKDLELFREEQFYESVLISERLAMILLHDRTADRLATMDPADLAEYRRYEWTLSIEARDTKDRIQDFNDRILELKSKIKPITNASDPTYYCLRRELMLNIHFRAELEYKTRSWLRRAGGPGLVLISPAGQALLDDIHELLRPIKDSLDTLDSCIRAAFHENQDPDDWRPNTRAKFFLGGHSRWSCRGEERGTCRIMELLQQEFDEQDRWDMDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9I5</accession>
    <name>A0A194X9I5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070792.1">
        <property type="nucleotide sequence ID" value="XM_018215078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9I5"/>
    <dbReference type="GeneID" id="28824804"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685413"/>
    <dbReference type="InParanoid" id="A0A194X9I5"/>
    <dbReference type="OrthoDB" id="4154357at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="302" mass="33725" checksum="DE03273C205A9D0F" modified="2016-10-05" version="1">MSSGSEPSGTQSSYASRFEQPAADQQPSGPDQVADSQLLADSQAWLEAHASNSVGPGVPQGSGSQHPSNSGQLADSQPPADSQRQSEVKPFSKEDTDRLVALSRRQKASEVQERPESQTSTLRERESFVVIESLGELVSLAEQHPKNGLPFRHLVDINKCLNKPSNLLRYHINFVLRRTTTYYPPFGTANNRVRANLKPMEDNLKDLPNPQIDTAWQEARLIAQIERYHQRKIDAPRFLAECIKAGVTDYILFVEGKMIVYMGAKGERYEEHFPDAETPNPETPDPARKRRKTNSNSKCTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAC6</accession>
    <name>A0A194XAC6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_72402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_72402"/>
    <dbReference type="InParanoid" id="A0A194XAC6"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268009" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8889" checksum="9B19413D34B2529E" modified="2016-10-05" version="1">MFAKILSAIIPLFSVFCFLSQASNLRSFRDHSSATVRKQSLSSSIYGTSLKHHPKCKPQLGNGSDSRNEIQPHYLPQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAW9</accession>
    <name>A0A194XAW9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_668628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071644.1">
        <property type="nucleotide sequence ID" value="XM_018213050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAW9"/>
    <dbReference type="GeneID" id="28822776"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668628"/>
    <dbReference type="InParanoid" id="A0A194XAW9"/>
    <dbReference type="OrthoDB" id="3483554at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF24494">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="283"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="55446" checksum="3F3A8872A84B5BF3" modified="2016-10-05" version="1">MPEPNASDGSASDPIANPDPEIGFASDEEDGDNRVAKKLRLDSEKLSSSQELVQHHAMEKSMDIVDDSEDEAPTLIVGPDEDDEDIEEDETIEKQTETSKEEEESAALVDEEEALDLKLNTPGTSRVVDDSLYDGYMSDDEIPPGTALPASQQESSKKRKLNDFNVSNKRTAELSKYEIAQGKLYKQLHDNIMFNLLLVNRLAEKLNSTHQPTDLAQLKEVVEQMQVDSRACMEKYKNATERKKSPNNNVPHPKTAKQILERLKGEEDNANPWGTTPEKSEELPDFAFRVFHDKSQSRIVDDRVGFQSAKAYGVLNTAALRKIKIERHANWKNRFLTSFISMSDSLPHLIEYFIPKFQEKYKIKKNPDNTKLTLININARTAAKYPTIPMGKQAGYYNVRLGSGKIFDAEYLALWEITPPQIVCKMKANRLALKRGERHSSVYIGASDYWLGKDLRAALLAAEAFQEQVAKPAYEKHETARLAAVAADAAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBF5</accession>
    <name>A0A194XBF5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_718185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071848.1">
        <property type="nucleotide sequence ID" value="XM_018218399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBF5"/>
    <dbReference type="FunCoup" id="A0A194XBF5">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBF5"/>
    <dbReference type="GeneID" id="28828125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718185"/>
    <dbReference type="InParanoid" id="A0A194XBF5"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000363">
        <property type="entry name" value="Nuclear condensin complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="635"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117285" checksum="44E1B62235188FCE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBK1</accession>
    <name>A0A194XBK1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_55677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071894.1">
        <property type="nucleotide sequence ID" value="XM_018208384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBK1"/>
    <dbReference type="GeneID" id="28818110"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_55677"/>
    <dbReference type="InParanoid" id="A0A194XBK1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268052" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7797" checksum="F488ACF7E9CC45E1" modified="2016-10-05" version="1">MAPLPPSLFLLLLKTCENATTSTILQGETVTAGRKKRSFLLLFYLDLFRHSSLQQNFEIQTRGVALKATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBL3</accession>
    <name>A0A194XBL3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_56716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071910.1">
        <property type="nucleotide sequence ID" value="XM_018208549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBL3"/>
    <dbReference type="GeneID" id="28818275"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_56716"/>
    <dbReference type="InParanoid" id="A0A194XBL3"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="270" mass="30226" checksum="F1940BD745E85D47" modified="2016-10-05" version="1">MADLQSGSCEPCKRKKCKCDRQLPVCGHCTTSQTECKYAESNKRGIPAGYLGALEARLNETEAALYNALCELRRFNGGGSFSYTNVIQPLSSHQNNTSKALRMKSWIQCPLQTSNDVENWWISFQENQTSYERDDTRPEPKTKDDSATHWHSHLNSQAQNSFTARATSRPTLESPGNMLYDVSNQSLEPCLQQSHTPPQLPDSNQPKVLSAATSGQFGFFDIQRLATRDESIGGSTSRPHEEASSQQIRGDSQHLTRSQQLSAEMSHIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBV2</accession>
    <name>A0A194XBV2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_781801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071991.1">
        <property type="nucleotide sequence ID" value="XM_018222514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBV2"/>
    <dbReference type="GeneID" id="28832240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781801"/>
    <dbReference type="InParanoid" id="A0A194XBV2"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="49725" checksum="C859CD87D5E644EA" modified="2016-10-05" version="1">MPFFAPHRVNESDHQLLVMGQGTVAVTANAEKISFSFKTKTEKGHTLTLEVRESIIDCFIVVDGKRSSKKSDSIKWEKLREGDLRLLEKGVLMPYWVSFDNVHGVICYGKYSVNRKMAILQANLKCELNGIVCWMGDHQWMDALENVQVQVWHDASAQSIPKIKIHRLPVFDVPAIVLPGFDTLGGLESGHHAALSDLPRACQDLYQTIQSISLASEFPDFANAVHRSVSIKGLIGHTLLTMKATTFSAAGNFLSTYLRITLGQNIGNSPGIPNVLEIWPAGHFSPIHDHGDSHAIIKVLHGEIEVSNYDSVTGRRRPQQIGDPLILKTGDVTWIGPENYQIYRLHNKFNDVCITLQCYRYDEATNYHHNKFRWVEENAQEAEVERRIGPEHVFDFVPNGDMTYTDFCESIQEEWNSYQQTLPHRWNVARSQRLMTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCB1</accession>
    <name>A0A194XCB1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_718413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072151.1">
        <property type="nucleotide sequence ID" value="XM_018218413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCB1"/>
    <dbReference type="STRING" id="149040.A0A194XCB1"/>
    <dbReference type="GeneID" id="28828139"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718413"/>
    <dbReference type="InParanoid" id="A0A194XCB1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ17796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="59700" checksum="EABF7B85AEF7A3EA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCI6</accession>
    <name>A0A194XCI6_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_732597</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A194XCI6"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="24200" checksum="B10605E79497F16B" modified="2016-10-05" version="1">MGNDQRCDSAISAVNSDASETRFESDEIEDFRSDRQPGKDASLKRPLRLSNAHRRRVSEASINGKSTNSGPVKSGKPTDASSSNTSTVVADFDVSFDFSPTEYGSATTPLFSPTEVNCICCGIPHPPLSHDDQFPEKCWEHQACLARGGWKKHLERVPHTRCPLSDCVKAGADFKTQEKFLQHWFKRHDEKCWYWGKKKGFFGSETAVWLQWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCP9</accession>
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        <submittedName>
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        </submittedName>
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    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_732647"/>
    <dbReference type="InParanoid" id="A0A194XCP9"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="32405" checksum="2086F97E9318441D" modified="2016-10-05" version="1">MLNGIYSPELSLNCDPDAVQLTDYAIQGNAKAIRMQRVSPGMVRIVNVKGRRPNHRLQAKFHMQQIPIAQHDRPRRFDGEARVDRVSPNMIGTVSTQHPICEQNTTPPPAAPEVPLPKEAPLILDVFPLFDCPAHSEETIKAFLSSPAHSKFSSTFLRIDEFHDGSRLAIHDATNESLLDFDPGDKEQGELGWIERPMDERIFDLKEMVGGWRRGDAIVVNGILGTVYFFRWKEDVDFIEERLGREGVEVRDFACKGRDEGNGGEGETDGPGSDKIPFDGTEMSRHVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCY3</accession>
    <name>A0A194XCY3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_746112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCY3"/>
    <dbReference type="GeneID" id="28830814"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746112"/>
    <dbReference type="InParanoid" id="A0A194XCY3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="125" mass="13999" checksum="61484891B9BE0876" modified="2016-10-05" version="1">MGFLPTALLSITLLNLTILGILFPFLGISIVSTLFVVGSLLISLYTGVSIVTLVFEILSWVSETGVVWRGVSYSRKVEKKGKKVSWSTEREELDENGRKWTKVDDDAGEWTEDEDEDDCVDYCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDA0</accession>
    <name>A0A194XDA0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_38710</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072489.1">
        <property type="nucleotide sequence ID" value="XM_018207159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDA0"/>
    <dbReference type="FunCoup" id="A0A194XDA0">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDA0"/>
    <dbReference type="GeneID" id="28816885"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_38710"/>
    <dbReference type="InParanoid" id="A0A194XDA0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="1186" mass="128936" checksum="06CA4CA1A68D345C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF70</accession>
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MOB_kinase_act_sf"/>
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        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25333" checksum="3BD604C842275847" modified="2016-10-05" version="1">MTSFITTVNQRTRNQFRPRNATKGTSSYQLRQYAEATLGGGSLRKIVKLPEGEDENEWLAVNMVDFYNHINLLYGSITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMPAPTYIEHLMGWVQSNIDNEAVFPSRIGVPFPKSFPSMIRQVFKRMYRVYAHIYCHHYPVIRELGLEAHLNTSFKHYVLFIDEHSLASGKDFWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFV2</accession>
    <name>A0A194XFV2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_780684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073007.1">
        <property type="nucleotide sequence ID" value="XM_018222407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFV2"/>
    <dbReference type="GeneID" id="28832133"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780684"/>
    <dbReference type="InParanoid" id="A0A194XFV2"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="81"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="520" mass="58872" checksum="282DA7F8DC8D475A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG67</accession>
    <name>A0A194XG67_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_557121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073122.1">
        <property type="nucleotide sequence ID" value="XM_018208390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG67"/>
    <dbReference type="GeneID" id="28818116"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_557121"/>
    <dbReference type="InParanoid" id="A0A194XG67"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="78" mass="8893" checksum="6E90695B46DF9317" modified="2016-10-05" version="1" fragment="single">KPCTLCQQPRNVLIRCQIDATRQWHFVCPGKCWRSVSGGTPDGDADHRDYRYGGTWKNKHEYVSAKIKGKAKDENKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGK7</accession>
    <name>A0A194XGK7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_487860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073624.1">
        <property type="nucleotide sequence ID" value="XM_018207864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGK7"/>
    <dbReference type="GeneID" id="28817590"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_487860"/>
    <dbReference type="InParanoid" id="A0A194XGK7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="495" mass="55798" checksum="76A15AF2A4BEA3E5" modified="2016-10-05" version="1">MTGVEKRKRASRPKSKGGCRTCKLRHVKCDESRPACKRCTRWGHQCDGYDDEIVAKKTTRVVYQLMPKSNAHPVVITCPSLGGIGFSHELEARYFRLYQEELSDELSAGFETILWNRVVLQACTNDSIRQLIIAIAALKKAGREPSANLASQHRKYALYEYGKALKGVQAALTLRRDGLRIVLIAALLIFVLESMFGDTKRAVTNIQTALDLINQRLLLMSHACRGPFITRGFLPPSFPDLIEEEILNSFLRLDRPAVGLLSRSKGSRPQNKMFSSKLYLEDFQIPETFSSIGEARLYYERLRFRVFPEHAFETKLKDTTSLPEGASAPAILLMELFSEITDESSAPAIRDDLARWHQAFGPLLRHSRTKEGSSTYVAAMMLQIQAAAISIPLFILNSIRESTDPAVTAARDVVQLSKALVADPRFPKTFVFEMGIIPCLWIVVILYPDFHLKREAIAVLRAMEPRVECVWDSKIVADTGDVVVEMLEKQQRQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGN3</accession>
    <name>A0A194XGN3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_706108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073649.1">
        <property type="nucleotide sequence ID" value="XM_018217499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGN3"/>
    <dbReference type="GeneID" id="28827225"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706108"/>
    <dbReference type="InParanoid" id="A0A194XGN3"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF29">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="126"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="429" mass="48393" checksum="C3EEF0C36C4875C8" modified="2016-10-05" version="1">MSPKYQTIYSTGIHHGLPTFPDHDGKKYTAIVTGANGISGSEIVNALVAAPERWETIYAMSRRPPRAVSDRVKTIAADFKDSTPEQLAKLFKSEGVKADYIFFTSYIQPPTQEGEGLWANHDELETVNVTLLSNFLEALTISSIIPKRFLLQTGGKHYAVHLGPTAIPMTEDTPDRRVPHPNFYFPQEDILSDWCEKHSTHWTVTRPGFIIGANPTAPINISYGLAIYASVQKELGKRLGFPADIGAWDINKDLSTASLIGYFSEWAVLTEEARNQAFNVVDDSPFSYGKFWPELAGWYGIEYDLPEQDEAKYNLVRMPRNPPPRGFGTPGVLKVKFSFEEWARSESIKETWEKIQEREGLTKELNPWKDKETLFNVFATLDAELLGGWARTQTMDKAKKMGWHGHVQTNEGMKLTIEKMIEMKMVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGY3</accession>
    <name>A0A194XGY3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_581722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073815.1">
        <property type="nucleotide sequence ID" value="XM_018209124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGY3"/>
    <dbReference type="STRING" id="149040.A0A194XGY3"/>
    <dbReference type="GeneID" id="28818850"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581722"/>
    <dbReference type="InParanoid" id="A0A194XGY3"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF8">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="105"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="346" mass="39429" checksum="7904A9AF47D039D4" modified="2016-10-05" version="1" fragment="single">MAYVTWTLKDRPQSLWKFDAVWIFGTGLDGGFAGEVGNGSWREKYPSLPVNSREALGLAKSWLERCESSHKICGVRRNDWHPTRLLYVGNNTIKLKTDMTTPVRYATLSHCWGKLHITRLETTNLDQFILKIPESALCKTFLHAIVVTRFLSLEYLWIDSLCIIQNDAEDWAKEAALMADVYGQSTISIAASGAVDGSEGCFFDRDNRYFWNMPFKVSESGKKQTLIMANTQIFERCIRHTELSKRAWVLQERLLAPRTLHFSKAQVSWECKEANACESYPNGFPEFLDMNSALDGFAKGATPSWEKVVQLYSRCLLTFEKDKLPALMGIAKMFQEATKMKYLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHA0</accession>
    <name>A0A194XHA0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_683404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073940.1">
        <property type="nucleotide sequence ID" value="XM_018214696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHA0"/>
    <dbReference type="STRING" id="149040.A0A194XHA0"/>
    <dbReference type="GeneID" id="28824422"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683404"/>
    <dbReference type="InParanoid" id="A0A194XHA0"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="416" mass="45387" checksum="433A0975CF1969E2" modified="2016-10-05" version="1">MADKKETEEIDYTLNNPDTLTKYKSAAQISHKVLEAVTALCVAGEKIVTICEKGDKLLEEEIGKVYRGKKISKGISHPTTVSPSSFVTPYTPLTSDEAEAAVTLKEGEAIKIQLGAQIDGFGTIVCDTIIIPSAENANDEISGRSADLLLATYWANELLLRLMVPPGLLATGTDEEKAKAAKIKAPTQSKITTLLEKVVKAYDCNLVEHTTSWEFERNEIEGKKKIILAPGDGTKGEGIPEVGDVWGVEMGVSLGSGKIKTLENRPTLHRRTTLTYALKRPSSKKILNEVVKKFGVFPFSLRQLEDERDAKVGVVECVRGNVFRQYEVVGDKDSEPVGRLLTTIAITKNGLQRLAAPPSPDLSKIKSDKKITDEEVLKILEQPLAKETKAKNKKKKSKLAKKAAAADDDDDESGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHX7</accession>
    <name>A0A194XHX7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074180.1">
        <property type="nucleotide sequence ID" value="XM_018222321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHX7"/>
    <dbReference type="GeneID" id="28832047"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779721"/>
    <dbReference type="InParanoid" id="A0A194XHX7"/>
    <dbReference type="OrthoDB" id="10410586at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19129" checksum="085268AE6C128657" modified="2016-10-05" version="1">MHASAPDLSPINEVTDTSLQESIQTSNRLSQVMDFEIQAGTEPLSLPNDMPTTPLDTKPSSNNTLITSSSTESTITPGMSEYEKSVVAKQSKEKAESEAWIKRFIEAQPNKRLLSCNDYEFQSKVADFRVRQALTMTVERDQAARAAAEVASGKKQKNQRGKGFRGWLRAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHY4</accession>
    <name>A0A194XHY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_459576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074101.1">
        <property type="nucleotide sequence ID" value="XM_018207674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHY4"/>
    <dbReference type="GeneID" id="28817400"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_459576"/>
    <dbReference type="InParanoid" id="A0A194XHY4"/>
    <dbReference type="OrthoDB" id="2980193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="575" mass="65211" checksum="795429C86EBA5CF6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLA4</accession>
    <name>A0A194XLA4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_578857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074912.1">
        <property type="nucleotide sequence ID" value="XM_018208970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLA4"/>
    <dbReference type="FunCoup" id="A0A194XLA4">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="GeneID" id="28818696"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578857"/>
    <dbReference type="InParanoid" id="A0A194XLA4"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000048">
        <property type="entry name" value="Zn-dependent hydrolase/oxidoreductase family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="48503" checksum="6CDD68BCC0B7C201" modified="2016-10-05" version="1">MRSFFQALLRRRPRSSQPQQRVSAIQARTISGGMTAAALYAVSMTTPTALGAVPEDAEAKSHHAKNGVGFINPWDSFKDFSAPEIMRKIIWGRVTGSFKSPDTTPPTVPVVAPKFLPNRTVSPALRATWLGHACYYVEFPSGLRVLFDPVFEERCSPFSWMGPKRYTEVPCHIKDLPVVDLVVISHSHYDHLSHPTVVELHKAHPEAQFLVGLGLKDWFQKCGIKKVQEMDWWTDIDITLSPSTGEKRISTASSTTVPSTTAPTDSSNITARISCLPCQHMSARTPFDKAHTLWCSWAVSSGGKSVWFGGDTGYRSVPQLPEGEDDYGEKYKDLPYCPAFKQIGDLRGPFDLGLIPIGAYDPRYIMSTVHANPFDSVNIFIDTKCKKAMGIHWGTWVLTGEDVLEPPRLLKQAMKWKGLPETGVFDVCDIGESREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLL3</accession>
    <name>A0A194XLL3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative invertase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_577239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075490.1">
        <property type="nucleotide sequence ID" value="XM_018208879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLL3"/>
    <dbReference type="FunCoup" id="A0A194XLL3">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLL3"/>
    <dbReference type="GeneID" id="28818605"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577239"/>
    <dbReference type="InParanoid" id="A0A194XLL3"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="414"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="59220" checksum="E221784A178A84FD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLQ8</accession>
    <name>A0A194XLQ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_771691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075057.1">
        <property type="nucleotide sequence ID" value="XM_018221890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLQ8"/>
    <dbReference type="STRING" id="149040.A0A194XLQ8"/>
    <dbReference type="GeneID" id="28831616"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_771691"/>
    <dbReference type="InParanoid" id="A0A194XLQ8"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="193"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="580" mass="63309" checksum="DD5F759D371F3464" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRJ1</accession>
    <name>A0A194XRJ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_636878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077024.1">
        <property type="nucleotide sequence ID" value="XM_018211505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRJ1"/>
    <dbReference type="FunCoup" id="A0A194XRJ1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="28821231"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636878"/>
    <dbReference type="InParanoid" id="A0A194XRJ1"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38663" checksum="8EA048330CA31189" modified="2016-10-05" version="1">MVSLKDIKKSNASLQDLPPGLVAVFVGATSGIGLGTLEALAKNANGPRAYIITRSKANATPIIDNLKLLNPMATFMPIEGQFSFIKDVDSMSEEIKRFETHIDILCISPGYLGLGGRHDTPEGMDTDSALQFYSRQRLIMNLLPLLERSSSPRVISVFAPGFEGPIDKDDLECRKHFDNIKACRAASTMTDLMFEELAKERPTVSFIHSYPGQVGGRLMDHALASASGLLWLPAQISRYTVLPVYTHLMCITPEEAGQRTLFLGTSTRFPPTTDHGITGKVDGFVERPNGVGVARSTVMKDGQGNGVYRVNWNAEIVKDSKLIDQYREEGYGKMVYDHTTNVFERSLSGNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS18</accession>
    <name>A0A194XS18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_637146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077199.1">
        <property type="nucleotide sequence ID" value="XM_018211517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS18"/>
    <dbReference type="STRING" id="149040.A0A194XS18"/>
    <dbReference type="GeneID" id="28821243"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637146"/>
    <dbReference type="InParanoid" id="A0A194XS18"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36981" checksum="17A92D500996CEB8" modified="2016-10-05" version="1">MAALTPATKDLLFIVGLGLTASALVATVRRMLLFSRDASIIPPSENKPSYITQDVEDSLKLGTLDKLLDSPNFCIQETTAIIICERALHDGTTIDALLWHIAQPNHDLREKGIRALSMMLNSSTVKIINKPSTYAALVKSLEYSVTDYEHNGYDLDWDNWHLRDIAEQGCLMILGQLVDKYGIEGVVKARFVERWLAKEPWGDTDEERFFFFAESLRKNYRLNEITVPLFRDRIGRRQLIKAKLIPHQFEMGTRQRDTRMINGESTAGEDFDGMFVESRRRRDQSAEDDRIRRRNREAMVLNDGTRPLGRDDIIQRDSTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS58</accession>
    <name>A0A194XS58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_664367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076917.1">
        <property type="nucleotide sequence ID" value="XM_018212765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS58"/>
    <dbReference type="GeneID" id="28822491"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664367"/>
    <dbReference type="InParanoid" id="A0A194XS58"/>
    <dbReference type="OrthoDB" id="4473276at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12417" checksum="39354631CDE1F25D" modified="2016-10-05" version="1">MVTKYLYSTGTSDIGEAKNFPWEYRVPDTEFFDPSGFKVGSTFLACFSEEEAQDMGLESKLSLSKTEKLALLLQTLQDKLKFEDDTAKPLSFYQVNYDNWRKVVFSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS91</accession>
    <name>A0A194XS91_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_728720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076952.1">
        <property type="nucleotide sequence ID" value="XM_018219292.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XS91"/>
    <dbReference type="GeneID" id="28829018"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728720"/>
    <dbReference type="InParanoid" id="A0A194XS91"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1315" mass="144298" checksum="8C8453B0BD9ECADB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTY1</accession>
    <name>A0A194XTY1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_755431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077849.1">
        <property type="nucleotide sequence ID" value="XM_018221350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTY1"/>
    <dbReference type="STRING" id="149040.A0A194XTY1"/>
    <dbReference type="GeneID" id="28831076"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_755431"/>
    <dbReference type="InParanoid" id="A0A194XTY1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="190"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33049" checksum="8AC085C66ECF6A75" modified="2016-10-05" version="1">MGAEKPGPYCAGINPVLNLGLLDQRVALEWVRSNIANFGGDVSRITLWGQSAGAGSTDYYNFAYPTDPIISGMIMDSSSALGAAPSPDPQGLNFTFVAGNLGCGNLTAAAELACMKNISQSHIEAFLKSYQDAGTAPTISFTPIVDNITRFDNYTARALAGNFSKVPAIHGTNNNEGSSLTAWINNGTTYNETAANINTVQRACWAQQTTHNHYAANTTTFRYYYTGNFSNISPRTWEGAYHSSELPLIFGTHDIAHSASTAFEYAVSHRMQDLWLAFMQDPVNGLPAQGWNAYAPGGDAIEFAWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTY3</accession>
    <name>A0A194XTY3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Condensation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_633312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078023.1">
        <property type="nucleotide sequence ID" value="XM_018211340.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XTY3"/>
    <dbReference type="GeneID" id="28821066"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633312"/>
    <dbReference type="InParanoid" id="A0A194XTY3"/>
    <dbReference type="OrthoDB" id="3545537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000017">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="597"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1178"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ23668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1308" mass="145842" checksum="BCDB47C524128710" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU47</accession>
    <name>A0A194XU47_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_1682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078088.1">
        <property type="nucleotide sequence ID" value="XM_018205551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU47"/>
    <dbReference type="GeneID" id="28815277"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_1682"/>
    <dbReference type="InParanoid" id="A0A194XU47"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="76" mass="8338" checksum="3C7780FED604A0B3" modified="2016-10-05" version="1">MTAGILLRWLGGRGFLCVHSGERPLTFRGKSLPDPRLPRRRFAVISFAVHTTSQYKVNGRVAVLPDSFATSLAPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUA9</accession>
    <name>A0A194XUA9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_5981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078260.1">
        <property type="nucleotide sequence ID" value="XM_018210018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUA9"/>
    <dbReference type="GeneID" id="28819744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_5981"/>
    <dbReference type="InParanoid" id="A0A194XUA9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16965" checksum="563B7F5A42A0D162" modified="2016-10-05" version="1">MSEFLLGGGLHPWITPVVLDLVNRVFEIQSPPLTVGLQFINISLGSPRMGFGLVLKETVADRETQCIIRLAVYHDHYFFLHHKGGFFGIGPMMRWLINGERCNVFAISGYAGLWDGNTDSIINVVMYCSNPCWHVACYFPLPNRCFPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVU0</accession>
    <name>A0A194XVU0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_679500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078698.1">
        <property type="nucleotide sequence ID" value="XM_018213884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVU0"/>
    <dbReference type="GeneID" id="28823610"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679500"/>
    <dbReference type="InParanoid" id="A0A194XVU0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="18853" checksum="5E2AC1A1739B7B0F" modified="2016-10-05" version="1">MKPPKRPAPDRTPSFEERPRKIVRLRVNSASLQDIQSKPQNPTLYHRAKSSSTKSASPSSRQSPGARSSITPSPSSTLSNGTITAVPASAPAVSATSTPMKVRKPLPDGSARTPLPEKVEKPARKPLPDSTSSGRKPLPSAPPTPSAEPVAAAPPRQKLLIKFNLKKAAAGIPPQDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWL6</accession>
    <name>A0A194XWL6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_679709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078978.1">
        <property type="nucleotide sequence ID" value="XM_018213931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWL6"/>
    <dbReference type="STRING" id="149040.A0A194XWL6"/>
    <dbReference type="GeneID" id="28823657"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679709"/>
    <dbReference type="InParanoid" id="A0A194XWL6"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="6">
        <location>
            <begin position="144"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="286"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="870" mass="97966" checksum="EA27D3914A1464E4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWT9</accession>
    <name>A0A194XWT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_703593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="495"/>
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    <dbReference type="GeneID" id="28827057"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:early endosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
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        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="473" mass="53157" checksum="1355EC00975583E5" modified="2016-10-05" version="1">MDHDDFDNVSWQNNPAAQGPASSIASPRGVSEDEGPGNTNGKQYAAVGGQLGSNADALDLAGVGEGVLECTVTNPLKENEGTKDAYVSYLVTTNTTFPSFQKPTTSVRRRFTDFVFLYKTLSKEYPACAVPPLPDKHKMEYVRGDRFGPDFTSRRANSLHRFLARLTLHPVLRRSALLIIFLESSDWNATMRSRPQRGNSGADQGATGVFDNFTDTFINAFTKVHKPDKRFIEVREKSDKLDEDLGHVEKIIARVARREGDLETDYKDLAEQFQKLINLEPGVEQSVHAFAASVEDTSLAMRNLKEHTDQDYLGSLRDMQAYSSAVKNLLKAREQKQLDFEQLTEYLTKSTSDRDVLASSHGAGAHIGASGFLARKVEDLRGVDHEQSRRERLRRIEVRIEELTTGVEEAKKTTEAFDEEVVREVQDFERIKRIEFKTQFGAFADAHVDFYASTIENWSRYVQEMENLGAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWX9</accession>
    <name>A0A194XWX9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_727685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24666.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219182.1"/>
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    <dbReference type="GeneID" id="28828908"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ24666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="74507" checksum="8E64A8CC8EB74E78" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1E5</accession>
    <name>A0A132B1E5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_415953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947452">
        <property type="protein sequence ID" value="KUJ06196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060551.1">
        <property type="nucleotide sequence ID" value="XM_018207371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1E5"/>
    <dbReference type="GeneID" id="28817097"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_415953"/>
    <dbReference type="InParanoid" id="A0A132B1E5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7456" checksum="B81EBEE0ED9ACC69" modified="2016-05-11" version="1">MMSSQKKSPRAKAEAGAGADDLSFSSEPEFLKENNELEHFENYNDQFEHLETRNDQFEHHTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1V1</accession>
    <name>A0A132B1V1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_564216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KQ947451">
        <property type="protein sequence ID" value="KUJ06213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060568.1">
        <property type="nucleotide sequence ID" value="XM_018208511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1V1"/>
    <dbReference type="STRING" id="149040.A0A132B1V1"/>
    <dbReference type="GeneID" id="28818237"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_564216"/>
    <dbReference type="InParanoid" id="A0A132B1V1"/>
    <dbReference type="OrthoDB" id="3552530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8203" checksum="D20306DB9956A5D1" modified="2016-05-11" version="1" fragment="single">YTADTGTAKQKEELLRTWLASSDQPYIVATSALSASFDYAHVRLVIHINKPSSLVDFAQESGRAGRDGKEAYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2F4</accession>
    <name>A0A132B2F4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_603033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060921.1">
        <property type="nucleotide sequence ID" value="XM_018210278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2F4"/>
    <dbReference type="GeneID" id="28820004"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603033"/>
    <dbReference type="InParanoid" id="A0A132B2F4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="36863" checksum="C9994EFC1BE22405" modified="2016-05-11" version="1" fragment="single">MDTYKYEPLDLDKPAVRLLRLLRGELGDVVECDLFQGWIDRDDSGMPYDALSYTWGGTEKPNTIKVHGTAMHVTANLYSALQHLRLKDEDRILWIDAICIDQSNVHERRHQVQHMGEIYKGAEHVVVWLGEGDVATDLLMGTMKRLEERLLEVSGDWRRSAHLWIQPWTDLQSSDERTNTHHRSHLRHGMSSILKRSWFRRIWVLQEIAHARVATIICGNKSISARVFAQIPPLIGLVVDNHCQAILDIMPGFTCKESWWNEDRSLHKLLMKFGHSEASDKRDIIYALLGISSDASDSKILIPEYTKSVREVIRDTTSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3H0</accession>
    <name>A0A132B3H0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_372825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061300.1">
        <property type="nucleotide sequence ID" value="XM_018207067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3H0"/>
    <dbReference type="GeneID" id="28816793"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_372825"/>
    <dbReference type="InParanoid" id="A0A132B3H0"/>
    <dbReference type="OrthoDB" id="3189033at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="480" mass="53849" checksum="B1A7225E2AE279A2" modified="2016-05-11" version="1">MSVGALVPNHTGKSVYLTPEQSPTALHIYDPFANPEGLDDLEDEKTDKSEDSLLKGAHQPGQNGTNAPTEKPGLPEAPPRPPGQGHSGYFDLKKEPPQLPLRSPNEPARSLKPTPTPPTRAGPAPFRQRATIPPPTIDEDDSASEDGKNGPPRYTRELHKLIAYLIPLPKPKLTKNTENEDSLPERFLIYTPPQPHFLKPAKGIKEPKKHWCKRKLQEEVQKAKKFDGKTLSLRGLHSKTTKGVVWAIHRIKSTDIVFLGRIQSEEVDEIVLISPTSVTHTIPEIRDEFVAQITRTKKKATKEAAISTFLLPVTLTIDTLAAIVWPFGGLFEIDVVWAYASIKGWNTSRIITKRLGARDSAFGKYGGKERDLYLRFQQDEKMEVLSKYLAECCHKKNPRMFDSAGVPPTEIEVMRAIGWTPVVRGRTGGERQEGETGWADEEWQSVVFEDDFKATMERGAGSWSKWCEKFEKKPEKMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3H7</accession>
    <name>A0A132B3H7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_603676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947450">
        <property type="protein sequence ID" value="KUJ06217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060572.1">
        <property type="nucleotide sequence ID" value="XM_018210315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3H7"/>
    <dbReference type="STRING" id="149040.A0A132B3H7"/>
    <dbReference type="GeneID" id="28820041"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603676"/>
    <dbReference type="InParanoid" id="A0A132B3H7"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="10899" checksum="E545D87367C649AC" modified="2016-05-11" version="1" fragment="single">VNYCLVTSPARRLLHEYQSARKLLEALRDAIQGYRLLLEDGKILYRDVFENNIIITELLAEDAPKGRLIDLDLAKELDGIQPKHKQIWSETIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B465</accession>
    <name>A0A132B465_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_371514</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061563.1">
        <property type="nucleotide sequence ID" value="XM_018207058.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A132B465">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B465"/>
    <dbReference type="GeneID" id="28816784"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_371514"/>
    <dbReference type="InParanoid" id="A0A132B465"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001053">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4717"/>
            <end position="4915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4081"/>
            <end position="4119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4145"/>
            <end position="4564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4084"/>
            <end position="4097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4162"/>
            <end position="4171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4172"/>
            <end position="4188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4192"/>
            <end position="4222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4237"/>
            <end position="4253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4254"/>
            <end position="4270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4272"/>
            <end position="4289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4302"/>
            <end position="4315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4322"/>
            <end position="4371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4418"/>
            <end position="4444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4469"/>
            <end position="4501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="4928" mass="551366" checksum="5335035EAAEB204E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B496</accession>
    <name>A0A132B496_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_692005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061600.1">
        <property type="nucleotide sequence ID" value="XM_018216450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B496"/>
    <dbReference type="GeneID" id="28826176"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692005"/>
    <dbReference type="InParanoid" id="A0A132B496"/>
    <dbReference type="OrthoDB" id="5097021at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="80" mass="8994" checksum="7119CCC4EAEC27DD" modified="2016-05-11" version="1">MSDGFLYKPEWQGLLCTQCGVCLRPGRSVWLRHLRQKPHYLRGAPLKALVELFATYGLLVPEQVAVPTQVVAGLRLQDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4G2</accession>
    <name>A0A132B4G2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_632359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061254.1">
        <property type="nucleotide sequence ID" value="XM_018211301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4G2"/>
    <dbReference type="FunCoup" id="A0A132B4G2">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B4G2"/>
    <dbReference type="GeneID" id="28821027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632359"/>
    <dbReference type="InParanoid" id="A0A132B4G2"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
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            <begin position="12"/>
            <end position="81"/>
        </location>
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    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
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            <end position="297"/>
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            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF26577"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5D4</accession>
    <name>A0A132B5D4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">LY89DRAFT_742854</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
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        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220883.1"/>
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    <dbReference type="OrthoDB" id="60033at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="473"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="859"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="986" mass="108664" checksum="CAD3B0F401AAC1F6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5X4</accession>
    <name>A0A132B5X4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">LY89DRAFT_789480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223258.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="423" mass="47724" checksum="3D188C8F3B6B2419" modified="2016-05-11" version="1">MADIITPSDLSSDDVDVIDIPWGKPSSYFSNLNASVSELSQFPRAQIASPTEKVSLRLLIIPCDHPPTSFAELLSVRSLRLAGASTLRDKHYLQVQRNTSGSACHLQAPARFLLQTPVDDDTFFSLAIKSNESKFSRFNGCFFCSGVEIPRFSTALKGEVIPLDWKDSDMPLAIIPLIILKHHVLMTTSKLESLMKEVGAIESRMSGADRLTLDFDDIILKLHLCNKNLVDLERRWRFESHLADTIRDFIKVTLLSRNWEIITTNSEKLKNDLAMQSRLDASEYDLNVLPRRITNQFTTIFNLIAQRDTKATIELATSSQKLAEAALRDSSSMKTIAAMTLIFLPGTFVCSFFSMTFFDWRASPETSVVTSLWVYFAVAVPFTIVVVLCWIAWTWKSRQEVGRGEKERATILPLFRKKALKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6A9</accession>
    <name>A0A132B6A9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_366630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061779.1">
        <property type="nucleotide sequence ID" value="XM_018207031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6A9"/>
    <dbReference type="STRING" id="149040.A0A132B6A9"/>
    <dbReference type="GeneID" id="28816757"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_366630"/>
    <dbReference type="InParanoid" id="A0A132B6A9"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16819" checksum="870980AFB372CE9C" modified="2016-05-11" version="1">MKLPKSDEHASRGLPITISASILDGLVLSLTPFHNSCNYRSAVVFGYATVVSDEAEKMWAMETITENTIRGRWENSRVPPTKTEMTSTSILRVRIHTASAKVRTGEPLEDRKNLKDDALTAKVWTGIVPSWLQWGEPIPTRTRSPIRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7G9</accession>
    <name>A0A132B7G9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_599958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062711.1">
        <property type="nucleotide sequence ID" value="XM_018210127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7G9"/>
    <dbReference type="STRING" id="149040.A0A132B7G9"/>
    <dbReference type="GeneID" id="28819853"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599958"/>
    <dbReference type="InParanoid" id="A0A132B7G9"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="193" mass="22063" checksum="1A13FF29645EDEA9" modified="2016-05-11" version="1" fragment="single">LREIFSTYGQIRDLDMPMNRAFNTNRGTAYILYASETDAEAAIAHMHESQIDGAVINVSIVLPRRKFSPSPPMARRGANIDPRVPLAAPFRPPPPTRRRTPPPAYGRTERNFDTYRPRSLSRSRSPRRHRTRSRSLSSRSRSRSPPRRRGGGRRDSPGRNGGRRRRSPSYSSYSSYDDRSRSRSRGRGGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7J8</accession>
    <name>A0A132B7J8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_561468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062745.1">
        <property type="nucleotide sequence ID" value="XM_018208461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7J8"/>
    <dbReference type="STRING" id="149040.A0A132B7J8"/>
    <dbReference type="GeneID" id="28818187"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_561468"/>
    <dbReference type="InParanoid" id="A0A132B7J8"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="23865" checksum="7DDE23B192E8E750" modified="2016-05-11" version="1" fragment="single">KPAAIFLVGDSTTAAPSGSGGGWGNGFLGTLVGGAIGTNFGHNGATTVSFVSGGDWTKVLASITKYKSTFLPFVTIQFGHNDQKSSANISIAEFSTNLKAMAQDVMAAGGTPILVTSLSRRNYDASGLIKPDLANVVNATLSVAMANWCPFIDLNKASMKYLNAIGEANAMMYDRVAGDSTHLNAAGDLLFGNMVSWFLSSSDIGVQVEAFLGPNATIVKAIEKGTFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7U2</accession>
    <name>A0A132B7U2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_599618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062831.1">
        <property type="nucleotide sequence ID" value="XM_018210106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7U2"/>
    <dbReference type="GeneID" id="28819832"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599618"/>
    <dbReference type="InParanoid" id="A0A132B7U2"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287958" evidence="1">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="32175" checksum="732E329D8B6916CC" modified="2016-05-11" version="1">MRRIYLLILTFVEHAFGQALLSILQSTPGTLSTLNSLINSSTTAKNLLSTANNFTFLAPSNDAFKKWLADQGPTSPSQDLIDATLSYHLVNGGFPTVLFSSKPQFVSTKLSSAAFTNVTNGQVVELFQNGKESEFLSGSKTLSTITSADIVCTGGLIHVIDTVLDVPQGLVTVITQSNLTFFIGGFLNVADQPLVLPVLNGPGVTIFAPNTASALSKFTSLTANATQSELGDVFNYHVVPNFSGYSSNLRNGLVLKTMQGDNLTITIQGNDTFVNQAKIISTDFLIANGVLHTIDRYVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8X8</accession>
    <name>A0A132B8X8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cap-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_599817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062804.1">
        <property type="nucleotide sequence ID" value="XM_018210121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8X8"/>
    <dbReference type="FunCoup" id="A0A132B8X8">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8X8"/>
    <dbReference type="GeneID" id="28819847"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599817"/>
    <dbReference type="InParanoid" id="A0A132B8X8"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="27353" checksum="8228D4E96EED2A6A" modified="2016-05-11" version="1">MSSMQTAGDIPLQIISENSSSERRISPSWTLGQFKAKLEPVTGIPPLSQRLILKRGSQQSIPLKAADEEKTQLGSFPLAPYAEIHVTDIRPPGMRQNFTDVTLVPKYEMPPSEYEQKTDSVLAWKKAKKLGRFDPNAPSIEQAKFEALETEVKQRGIEVGKRCRVGGEDAKRGKVMYVGEVEEIPGGAGKWIGVKLDEPVGRNDGSLGGKRYWGKEGDPKFGVFVRPERVETGDFPALDDLDDLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA00</accession>
    <name>A0A132BA00_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-carboxy-cis,cis-mucoante lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_658145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063428.1">
        <property type="nucleotide sequence ID" value="XM_018212461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA00"/>
    <dbReference type="GeneID" id="28822187"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658145"/>
    <dbReference type="InParanoid" id="A0A132BA00"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288009" evidence="2">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="43209" checksum="4DBE86A2924DE3C5" modified="2016-05-11" version="1">MSPIICALFARLALVPTAFAATSTLLVSHFSGALFTLSLNAQGNNGSLAITSATGGCGTTPTWLQYYADTKKLYCWDESWQGYGTMAEYNVSSDGSLIVNGQAKTSGNDVHGVLYGGPSGRSYMATVEYTPSTLTTYALPLKAGPDRPYTVPHQMETFYMASPGPNDRQKDGPHPHQALLDPTGKFLIVPDLGADVIHIFAINAASGHLNACPDAQTAPGDGPRHGEWWSPKGNTSSPDGLRLYTVNELGNSVTGWSVTYGAGCLSLNRTQTISTFAGGKIPAATVYEGASYPAKAAEVHIVGNFLYAANRNDKLFGNQTDSLATYSIDPATGTVSWIEATSAHAFYPRSFNFNKAGTMVAVGGQTSSTISIIARDSVSGKLGPLIASMQVGTQGTYTNEDGLSSVVWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA43</accession>
    <name>A0A132BA43_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_657561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063630.1">
        <property type="nucleotide sequence ID" value="XM_018212434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA43"/>
    <dbReference type="FunCoup" id="A0A132BA43">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BA43"/>
    <dbReference type="GeneID" id="28822160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657561"/>
    <dbReference type="InParanoid" id="A0A132BA43"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23342" checksum="1FF1EB11E4EF9301" modified="2016-05-11" version="1">MSNTISPADAKILKKEPLDTKDARWTRLILTTYTDPQGKERTWEHAERPTRPKNSEVDGVGIVAILDKPTGPEIILQKQFRPPINAVTIEVPAGLVDAGETPEQAAVRELKEETGYVGVVSETTPVMFNDPGFCNTNLRMIHVTIDLSLPENQNPKPELEENEFIEVFTIPLKDFYPELKKLEAQGYAMDARVATIAEGFELAKRWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAC2</accession>
    <name>A0A132BAC2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_598040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063686.1">
        <property type="nucleotide sequence ID" value="XM_018210012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAC2"/>
    <dbReference type="GeneID" id="28819738"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598040"/>
    <dbReference type="InParanoid" id="A0A132BAC2"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="548" mass="60792" checksum="76F41D3A5CF234F8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAC9</accession>
    <name>A0A132BAC9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_537489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063696.1">
        <property type="nucleotide sequence ID" value="XM_018208118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAC9"/>
    <dbReference type="GeneID" id="28817844"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_537489"/>
    <dbReference type="InParanoid" id="A0A132BAC9"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="69" mass="8402" checksum="1708B8D818E5AC76" modified="2016-05-11" version="1" fragment="single">MRPDYWLIDHLWTNGLLSIEVYQHAIKYNERPPCTELVPLGYETKTMSYKRERSLQQLYDLAKESRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAT7</accession>
    <name>A0A132BAT7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_741097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063738.1">
        <property type="nucleotide sequence ID" value="XM_018220662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAT7"/>
    <dbReference type="GeneID" id="28830388"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741097"/>
    <dbReference type="InParanoid" id="A0A132BAT7"/>
    <dbReference type="OrthoDB" id="3549067at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="52374" checksum="400E11D07DDFAECF" modified="2016-05-11" version="1">MRTPTQAHPEAHPFKLQPTIHHVFDKEQTFLLPDLHLGNSILARDIKRNRKGLNRRGAWAEAELFILSKLRMGFHPEVIDSEICSEILSNEGSDYKTMFLKYARRILVNLRTSSILGHVPTIAEYNVIAIVQDQRVRFQMMMYERLQDSRLVNQYGMDDEIARELKSAEALNIQQEQMLQQMREQDQRQVEEQYRANEEALRSELADAKFRAESAENQLKYQNAMRSRQPSNAGSSRTPAFENDFPRFRTNGTSRYAPAEGDRTRASDVDDMRSQRSFRPGFDDRGMPMNQRAGDPDRKPAEEGYRYVEGVRFGRDHVPQNRYSNGQGQGRGHPTPGNRYVGPRQNEDRGNPQHRQPYNQGQENYRGTPDPRDRAPPQKKISFRTVKVQDVQFPKTTIRMSSAHSIVPPVTTIVDPRKARSPTAIMNNVVLRDFEKECVLRGMNRSYTQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB18</accession>
    <name>A0A132BB18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_274078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063967.1">
        <property type="nucleotide sequence ID" value="XM_018206389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB18"/>
    <dbReference type="GeneID" id="28816115"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_274078"/>
    <dbReference type="InParanoid" id="A0A132BB18"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="29844" checksum="B6644DE5BC50D362" modified="2016-05-11" version="1">MAFPEPSLASSVSTMVPATFHPFPRLPTETRTQIWAYSFEPRVLTIRGLTSVLLIDPRNLDSGVIELPWDPRDPNWRRKRTLLVKTFIVFEGAHSDLKAMESWVGGSAPSGHVLAKQDEPIVRAPMAPVALYICRESRTMALARYALGFGAIQKHSDSPHRLGDSRWEEHGMIEKTTWVDWERDTIMIPLYPCRRICLEDNPLIQRLAVMEREMWLQDLTPIQFLVDILKILIHFKTLLVYIRPTNVAKDPLHPEEMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB19</accession>
    <name>A0A132BB19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_597745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063936.1">
        <property type="nucleotide sequence ID" value="XM_018209991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB19"/>
    <dbReference type="STRING" id="149040.A0A132BB19"/>
    <dbReference type="GeneID" id="28819717"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597745"/>
    <dbReference type="InParanoid" id="A0A132BB19"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="395" mass="42259" checksum="5DBB6668CC28E83A" modified="2016-05-11" version="1">MSPKVFIISMFSPEADIWYANADTPGSIGDLLAINVTVPGFSPLFPDAHCLADGSVCQLTTGESEINAASTITALLSTPLFDLTRTYFMIAGIAGINPKYGTLGDVAFSKYAVQVALQYEFDAREIPSNYTTGYIPQGAYAPDQYPTSIYGTEVFEVNEALRAIAVKYASTAKLNDSSAAVAYRAHYASADTTIYEAATKAPGIIECDVATSDVYYSGALLGEAFENTTTLFTNGSGIYCMTAQEDNATLEAMVRAAIRKAVDFSRIIVMRTASDFDRPYFGESVEDNLFYADQGGFEPAIQNIYLAGTPVVKGILSGWEKTFAKGVNATNYIGDIFGSLGGTPDFGPGAEFGAAGLVTRDVEVEEVRDRRALYRRSAVKGKLGAEVARRANGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBE1</accession>
    <name>A0A132BBE1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_761462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064095.1">
        <property type="nucleotide sequence ID" value="XM_018221548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBE1"/>
    <dbReference type="STRING" id="149040.A0A132BBE1"/>
    <dbReference type="GeneID" id="28831274"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_761462"/>
    <dbReference type="InParanoid" id="A0A132BBE1"/>
    <dbReference type="OrthoDB" id="3549254at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14336" checksum="5BBBDAA3E4958C73" modified="2016-05-11" version="1" fragment="single">GKNGRIYVTRRVDERRCPDCIKSVYKSGRTTVMIWGALSWDYKSPLVFLEKLPERKGICSKAYLQQVLQPIIFPLFDDLGPEYIFIEDGSKVYKGHAKLPRLQHNIRGFNWPPSSPDLNPIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBX0</accession>
    <name>A0A132BBX0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_690174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064118.1">
        <property type="nucleotide sequence ID" value="XM_018216046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBX0"/>
    <dbReference type="GeneID" id="28825772"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690174"/>
    <dbReference type="InParanoid" id="A0A132BBX0"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="385" mass="40790" checksum="6C19EBA4A32395E1" modified="2016-05-11" version="1">MNSFGVFQTYYESLLPDSSPSAISWIGSIQVFLLRFVGVITGPLHDIGYFHTLIGTGTFLVVFGTMMTSLGTQYWHFLLAQGFCVGLGAGTLFMPSVSSLPQYFSTKRGLAVGVAATGSSLGGVLYPIIFRKLEASIGLGWAVRVLAFLSLATGSISLSVMRLRHHPSLSRIGNSPSPNTSSNAAGTKKQTRTLLDLTAFKEAPYDFFCVAIFLGCVSFFIPIFYIQSYAQSTSSSGHSIPTSLTTYLLAILNASSIIGRLSSRFLDRHAGPVNMLMLTSILTGTLSLCWIAIPPSSEGGLVTFAVLYGIFSGGFISLPAVAVASLTTDMRRLGTRLGMNSAIGGFGSLCGTPIAGAILDGSGGWIGLKVFAGVSMLACRLPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBZ2</accession>
    <name>A0A132BBZ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_723794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064297.1">
        <property type="nucleotide sequence ID" value="XM_018218847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBZ2"/>
    <dbReference type="GeneID" id="28828573"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723794"/>
    <dbReference type="InParanoid" id="A0A132BBZ2"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="63815" checksum="B6639A9BAB4054F0" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCH7</accession>
    <name>A0A132BCH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064433.1">
        <property type="nucleotide sequence ID" value="XM_018220594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCH7"/>
    <dbReference type="GeneID" id="28830320"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740476"/>
    <dbReference type="InParanoid" id="A0A132BCH7"/>
    <dbReference type="OrthoDB" id="3560191at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="228"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="695" mass="78866" checksum="144046BC742903C5" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD63</accession>
    <name>A0A132BD63_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_272029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064548.1">
        <property type="nucleotide sequence ID" value="XM_018206372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD63"/>
    <dbReference type="GeneID" id="28816098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_272029"/>
    <dbReference type="InParanoid" id="A0A132BD63"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="408"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="615" mass="70003" checksum="7A25DC265CDD2745" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDP0</accession>
    <name>A0A132BDP0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_656364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064890.1">
        <property type="nucleotide sequence ID" value="XM_018212380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDP0"/>
    <dbReference type="FunCoup" id="A0A132BDP0">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BDP0"/>
    <dbReference type="GeneID" id="28822106"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656364"/>
    <dbReference type="InParanoid" id="A0A132BDP0"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="316" mass="34294" checksum="FA20E6143995BB35" modified="2016-05-11" version="1">MPRGRPVKHHFVAALGEFVGTFLFLFFAFAGTQTANESTSTSTADTGPNLLQLLYISLVFGFSLAINVWIFFRVSGGLFNPAVTLALCITGVVPVLRSVFTFIAQILGAIAAAGVVKGLIPGSGVLFNVELQSGMSIPQGLFLEMFLTAELVFTILMLAAEKTKATFVAPVGIGLALFVAELVGVYWTGGALNPARAFGPDVVTGKFNGYHWIYWLGPVLGALLASSFYALIKYLNYEEVNGDQDKSQDEEHILDIVRKNTDPGPKPSSRQGPRGSHHSHRSQRSNRPGSGHQQGQGEPTRHYQEYERNRDGPHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDS7</accession>
    <name>A0A132BDS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_597243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064504.1">
        <property type="nucleotide sequence ID" value="XM_018209969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDS7"/>
    <dbReference type="STRING" id="149040.A0A132BDS7"/>
    <dbReference type="GeneID" id="28819695"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597243"/>
    <dbReference type="InParanoid" id="A0A132BDS7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288154" evidence="5">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="347" mass="38376" checksum="09F7B34FC2FD77FD" modified="2016-05-11" version="1">MYFSTILLAVTAAVSPTLAQTQQPIIVPQETISQPLLGFGTWNLKVSPENTSAVVSLAIQTGYRQIDCAAIYGNEKAVGKGIADGLEKAKLNRNEIWVTSKLWNDHHGDYETVEEALNQTLKDLGLEYVDLYLMHWPVTTSSKEPKLDYVKTWKSMANLPKAKVLNVGVSNFSPEQLRHLVTETGIKPAVHQMEMHPYLQQTSWLATHQALGISVTAYSPLGNSNPTYDPSSTCSKTSLLSFLSSLFTGDKQTPPPLLKNPTIQAIADRRKCTTAQVALSWGMGRGTSVIPKSKHEKWIVENYESLKCELGVVDLVELKKVGVDWTTRYNNPSKGWGVKLFEGLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTN3</accession>
    <name>A0A194WTN3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_594965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065399.1">
        <property type="nucleotide sequence ID" value="XM_018209833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTN3"/>
    <dbReference type="GeneID" id="28819559"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594965"/>
    <dbReference type="InParanoid" id="A0A194WTN3"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF2">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28246" checksum="5109658697CFD8B7" modified="2016-10-05" version="1" fragment="single">KFLTEYSEIPDDKILPHVYEIRDKAWAIRSYPCTGQGLFLNSLITRSPVYSEVLEKLKAGGRLVEVGSFIGHDMRRMAFDGAPSSNFYAVDIVNHWDVGYSMFNDREKFHAHFIESDIVHTNSQLQELNGTVDIIYISKVFHQWDWDTQFAALRSIIALSKPGAIVFGFHAGTIQGGLLAYSNGGLTMWLHDETSWTRIWEEAGKETGTKWDAGQVSMRDISEMASSPESLAWLDGNCRLMDFVARRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUB6</accession>
    <name>A0A194WUB6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_758255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065906.1">
        <property type="nucleotide sequence ID" value="XM_018221430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUB6"/>
    <dbReference type="GeneID" id="28831156"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758255"/>
    <dbReference type="InParanoid" id="A0A194WUB6"/>
    <dbReference type="OrthoDB" id="3559685at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56502" checksum="F3889F393C8C42B6" modified="2016-10-05" version="1">MCDPVNELALLTLGTKVIKSSDGLSKSKKRKERLKRKRDLKQQAAQQEVRTQLALLKKEKEDAQQPFRFLDLPYDIRLMIYNILYVRPVWIRPAVNFYRHRPSAALTVKYSVYRYQWGCQPQELPQTSDRDLPTREGERRAVAISWSDDPTPAQLKALENGATWLPDTKIASNDRSNISNDVSYGTIRISHQQLLYISGFFGVRLLRTCKQLREEGTQILYGDNKFCFDFDLRNRYSSTRHPQNSDHIPGFSDDEGRKPSEEEINRDLDRLFDKTCHHSAFVWRDPLLHFLTRIGPYNARILKSIKLSGSFKTLFPMYRLGCFEDRLPIYTTVLSRVCSNLCRLYIEADIPSEIFGPGTLSWCIIRHDTNLELTELSDHEMLYNIIGTLVEDLPQLTKLHLGWSGDETKDMVWDHTQRSYEESLWGDALEWVDIVAERAERGGVVLDSNVKPVETPRISTMIQEKEEENVGTGEAKQPATSSQQPLLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUG3</accession>
    <name>A0A194WUG3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_242251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065664.1">
        <property type="nucleotide sequence ID" value="XM_018206119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUG3"/>
    <dbReference type="GeneID" id="28815845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_242251"/>
    <dbReference type="InParanoid" id="A0A194WUG3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267544" evidence="3">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="30635" checksum="69B420FD207ED821" modified="2016-10-05" version="1">MRYAYLLLSAVTLLAKVHCAPVADNANPTVTISSGVVIGTAKAIISAAQSTTTVYNYLGIPFAAPPTGTGRFAPPAAPTAWNSPLEATALPPACLQQFIYPESTAEFLEEVFNNPGGPAPPESEDCLYLNVFAPTDASPSNKKAVLFYIFGGNLQFGTGSLLNYDGSSFSGFQDVVVVTFNYRTNIFGFSASPELPTGQQNVGFLDQRLALQWVQDNIAQFGGDPSQVTIFGESASGVSVKQLMAQPPSPLPFRAAIMQSEQAVLPGTGLASYQATLREFGCTDERKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVE3</accession>
    <name>A0A194WVE3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IlvA, threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_216023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066290.1">
        <property type="nucleotide sequence ID" value="XM_018205904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVE3"/>
    <dbReference type="FunCoup" id="A0A194WVE3">
        <property type="interactions" value="1178"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVE3"/>
    <dbReference type="GeneID" id="28815630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_216023"/>
    <dbReference type="InParanoid" id="A0A194WVE3"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="6">
        <location>
            <begin position="65"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="418" mass="44718" checksum="39E8388DC12AB87F" modified="2016-10-05" version="1">MADPKKSPPLTRDSVIAAHALIKEHIHYTPVLTNTTLTDLASTPQAPAALVGTPWVGQEPAKPIIRLWFKCENLQKVGAFKVRGAFHALKRLMTEQGWEEGGGREKGVVTHSSGNHAQALSLAARTMGVPAHIVMPTISTPSKIAATKGYGANVIFSGSTSVKREAVVEEVIKKTGARLVPPYDHPDIMLGQGTLGIELQEQVERMIASGQSEGQSQPKCSFKLDGQGKGKRKGLNAIIAPCGGGGMLSGVALSCENTGISVFGAEPEFEGADDCKRGFESGKRVEIVKTLTIADGLRTPVGVYPWSVIYERRLVRQMFSVSEEMIKKALKLVLERMKVVVEPSAVVPLAVALFNEDFRKMVEKEGGEDGWDLGIVFSGGNVSLEALGKLFEVPAEKAGRQEGKLGKDGEKVAENVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVY5</accession>
    <name>A0A194WVY5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_624569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066480.1">
        <property type="nucleotide sequence ID" value="XM_018211047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVY5"/>
    <dbReference type="GeneID" id="28820773"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_624569"/>
    <dbReference type="InParanoid" id="A0A194WVY5"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="145" mass="16751" checksum="A6D523B7CDB92AD2" modified="2016-10-05" version="1">MISNQMSLLQSSSRIFRHQRSFKFIPRHQFLRTMASAPEKFEWMVIIPDVPGKLEKRMEVRPKHFEGLKTAMEKGFFKTGGALLDEVPKEGEGLKISGSTVVAWASSKEEVMEILKGDIYAKEGVWDLEKVQIWPFKCAFREKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWA2</accession>
    <name>A0A194WWA2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_673751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066304.1">
        <property type="nucleotide sequence ID" value="XM_018213386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWA2"/>
    <dbReference type="GeneID" id="28823112"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673751"/>
    <dbReference type="InParanoid" id="A0A194WWA2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267617" evidence="2">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="103" mass="11660" checksum="BFDDF624D4D806C7" modified="2016-10-05" version="1">MAVPFILPVLTMSLLFSTCQFSLSRKSGVVKIPNSFPYIHIPNLCTPRFDPDVIGSCCRILHPQVPYMQNNNEAQVHDPLLRAQEVVPDKEDKAPEDIGERFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWL1</accession>
    <name>A0A194WWL1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF647-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_709933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066424.1">
        <property type="nucleotide sequence ID" value="XM_018217792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWL1"/>
    <dbReference type="GeneID" id="28827518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709933"/>
    <dbReference type="InParanoid" id="A0A194WWL1"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="45"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="472" mass="51660" checksum="1C7DB2E348E2F23F" modified="2016-10-05" version="1">MAQKPISDSHIEIEETDQANNLVATYITSPSGEKGRRVDIIIPRDSTNYARSILNAFLPAGYPHSVTSDYLEYQIYDSLQAFSSSIAGMLSSRAVLEGIGVGDSGASPTAALLLSVLQESMGRIATILFAHRLGTSLEPECKMYRLAADIFNDAAMILDCLSPALPKASRVMLLSLSSVLRALCGVAAGSSKASLSAHFATQGNLGELNAKDSSQETIISLLGMLAGSLVVSRISTKLATWTAMIFLLAIHLGTNYLAVRAVCMRTLNRQRANLAFSTALDHVEKHADNNNLWRGLIALDTLLGPTPNDIRRRERVFEEDGVLRWNGEALGHCKVGVDLGTLLSCFNRKDETTGSYTDAPDFGRLLTIFNDVPYIIWFDEPNKMFLVVLGKDASPEAELSAWLFALYFAKHGKEKDEVLLDALKRTLEKIRGIDRGILGHLERVGWDTKTSALETQSGTRIKRPAHPQGFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWR3</accession>
    <name>A0A194WWR3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_786166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066377.1">
        <property type="nucleotide sequence ID" value="XM_018222957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWR3"/>
    <dbReference type="STRING" id="149040.A0A194WWR3"/>
    <dbReference type="GeneID" id="28832683"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786166"/>
    <dbReference type="InParanoid" id="A0A194WWR3"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="42675" checksum="FC6B04A1F06DBBDF" modified="2016-10-05" version="1">MANRAAALDKNIYTIRDLKEAATKKLPKMYAEYFNEGAMDLITLHDNEEAFNRYKIRPRILINVSNIDTSTTIFGTKVSFPLGFAPAAMHCLAHPDGEIATSRAAAKNGIAMGLSSWSTCSMEDVVKEGLGNPYAFQVTLLKDREIAIRMLKRAERNGYKAILLTVDGVVLGRRLNEFRNSFSLPSGITYPNIESEADPSALAGADDSLNYGSKTSPDQKARLFTELMMEKKDADVDWASVIPWLKKNTSLPIWVKGLYTAEDVSLAIQYGLDGIIISNHGGRQLDTAPATLDALRECAPVAAGKIPIAIDGGIRRGTDIFKAIALGACFCFVGRVPIWGLAYNGEAGVDLAIKLLMNEFETTMALAGCKNVKEISRAHLSILRPDGVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWZ3</accession>
    <name>A0A194WWZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_738284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066856.1">
        <property type="nucleotide sequence ID" value="XM_018220355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWZ3"/>
    <dbReference type="FunCoup" id="A0A194WWZ3">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWZ3"/>
    <dbReference type="GeneID" id="28830081"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738284"/>
    <dbReference type="InParanoid" id="A0A194WWZ3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="574" mass="62365" checksum="BFFA86939403BDD5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX04</accession>
    <name>A0A194WX04_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_652986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066866.1">
        <property type="nucleotide sequence ID" value="XM_018212226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX04"/>
    <dbReference type="STRING" id="149040.A0A194WX04"/>
    <dbReference type="GeneID" id="28821952"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652986"/>
    <dbReference type="InParanoid" id="A0A194WX04"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="374"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="802" mass="90293" checksum="1FCAE0B95C3ACD56" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX11</accession>
    <name>A0A194WX11_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_673995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_673995"/>
    <dbReference type="InParanoid" id="A0A194WX11"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="193" mass="21242" checksum="245CBFD50F350B26" modified="2016-10-05" version="1">MIFTIGSNHLEGTEANDLSWKACLGRSVLGYYENNPVEEVRNREDFAGPIEHPTSARPQVKLPGHWESTDATTVEGGGGGGLKDGEIDDAVQLDGTDLGDVELEDLLELEEEDGKLIVDTSVNEESLADFLRNAPPPPPEPTSVQGGPQRPSYEPAEILTHEWNKYRDTVIATAGVDQLIRNFYCFYKQTGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX28</accession>
    <name>A0A194WX28_MOLSC</name>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_592698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KUJ12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209713.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="28819439"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592698"/>
    <dbReference type="InParanoid" id="A0A194WX28"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="90"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="604" mass="64946" checksum="E2E28D06B5C87BA4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXD2</accession>
    <name>A0A194WXD2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722199</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXD2"/>
    <dbReference type="STRING" id="149040.A0A194WXD2"/>
    <dbReference type="GeneID" id="28828438"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722199"/>
    <dbReference type="InParanoid" id="A0A194WXD2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="53"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="364" mass="38925" checksum="8061DB4964CDF0E2" modified="2016-10-05" version="1">MSQKKTVIINGLVFDGHELHQNLAVAIENGVISNLGNVPDTSYTTIIDATGQTLLPGLIDAHVHLTADLENTCHLLTQMARAGITTALDMGYLPKPIRDAVRDQPGMTDIRAAGNYATSTGSTHSRFPHISKESLVDSSELAISFVQTRIAEDAEYIKIVADIPGPSQEVVDTLAAEARKAGKLSVAHAARKGSFAMAQEGKVDIVTHVPLDFPLDEDEAKKMKDEGRVCVPTLIMEQGLAKAGIFPGLDYTAARESVSRLHKAGVSIVVGTDANQSPRAGVRHGDAIHEELKLLVDAGMSNLEVLRGATSASAEAFRLYDRGVIAVGKRADLVLVNGNPAESIGCTKDMVRVWIHGEEVKTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYT2</accession>
    <name>A0A194WYT2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067476.1">
        <property type="nucleotide sequence ID" value="XM_018213348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYT2"/>
    <dbReference type="GeneID" id="28823074"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673218"/>
    <dbReference type="InParanoid" id="A0A194WYT2"/>
    <dbReference type="OrthoDB" id="10520463at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17119" checksum="F1AA811518E9EA06" modified="2016-10-05" version="1">MIPTVQHLFNTIHSLSTARITFWPDSSCMIQSQRREVSVKMPFSSGARRLRIGSGRKRCFLGAATVTFTTMFVARNSISTITSRQISDIKESIMRLRRHGYQWHSLPGGLDFVTGPKEDTETKERKSKEEPAETALEHKTGKKFRTKNACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1C2</accession>
    <name>A0A194X1C2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_151782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068351.1">
        <property type="nucleotide sequence ID" value="XM_018205402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1C2"/>
    <dbReference type="GeneID" id="28815128"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_151782"/>
    <dbReference type="InParanoid" id="A0A194X1C2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="125" mass="14162" checksum="BC0EE504474CBA55" modified="2016-10-05" version="1">MARMLTKITEMRNSVIYSTSSMYLYVRGLQEQGERNTSSIIGDKGNTLITPSPSSSPFLHCMCMRAHTHTHTHTHIHTHRHSNLMVSQRGGNEASLSWRIINGWDQLETLYHTTSRLGPPRQCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1E6</accession>
    <name>A0A194X1E6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_590404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068027.1">
        <property type="nucleotide sequence ID" value="XM_018209594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1E6"/>
    <dbReference type="STRING" id="149040.A0A194X1E6"/>
    <dbReference type="GeneID" id="28819320"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590404"/>
    <dbReference type="InParanoid" id="A0A194X1E6"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="33268" checksum="B6F75B2B73C39CA9" modified="2016-10-05" version="1" fragment="single">IIMEPYDYVSALPSKGLRKGLLDALNSWYCLPEKPLAAIEKIVDIEDGSSERRGKPASHIIFGASKTINSADFMMITCLEKVSLLENKACLAAYIEEMKEIYVGQGLDLHWTHHSTPPTKDQYFLSIKQKTGGLLRLMARLMHACSIDTRSSSAIATDASDSLAKINQLMIMIGRYFQIRDDYKDVVSAKDDIVSGIQADLDQGNFILPLLHLLSQQKTIHSTQLLSLIQAREEVKGMSLAMKGHILDMLENAGSLEYTRKALEKLYEEILGKLKDIESDFRGENAELRHILAKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1W6</accession>
    <name>A0A194X1W6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_131191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068543.1">
        <property type="nucleotide sequence ID" value="XM_018205243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1W6"/>
    <dbReference type="GeneID" id="28814969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_131191"/>
    <dbReference type="InParanoid" id="A0A194X1W6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="16254" checksum="EE199FCBD699467F" modified="2016-10-05" version="1">MHTHHHHPPDPYISSHQHTRHSNQKTTATSNHVHRNNNNPPLPTHPHPLHNLLPLRLRLRLHSLSFPLGPETAPARHLRGVPPAVPTRADKPAPRRLARIADAAAAEGAQRDGGVGGAEADRGGAWGEEEGGGADWGDAVGWSCEVGRKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2T2</accession>
    <name>A0A194X2T2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-propionate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_620457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068507.1">
        <property type="nucleotide sequence ID" value="XM_018210915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2T2"/>
    <dbReference type="GeneID" id="28820641"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620457"/>
    <dbReference type="InParanoid" id="A0A194X2T2"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF6">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="602" mass="66934" checksum="3976E0A9D33CA648" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3C1</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_118842</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
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        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="397" mass="41420" checksum="00548D35B64428A7" modified="2016-10-05" version="1">MSSPGGQGQQGGAGSSNGGSSGGQGNQGNPTQATSTTAASSHGFATSTSSPSSTTQTSNPTSTSSSSSSNSNKTAVIGGVVGGIGGLLVLSLILIWFLNRRKKRQIAVKNGTVQPVTYAGLNSSFAGVHFAHGSNRSPHDSLMPAPLLLSSSTNSSHPDIEMRGGQSSPERHSATESDIFLPTYAESQAGMSMYGRSSLGRLNTSHTAPSTNVSPLSSVGTRDLHNFSPSDLPPIPPLPVNGRERDTMGFPIEPGMVTPPLESPGPASHGFETIHLEPEAPLPIISPRPRHPLVQQDSLERQVRQGMMPIDSPEPSQPINPNRLRVLSQEMPRESPILGLNSATIQPQAGPSNLNPNADINRMASQRTVSSMNSMPPVVSDAELESLGVGMRPAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3K5</accession>
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        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_686413</name>
    </gene>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069106.1">
        <property type="nucleotide sequence ID" value="XM_018215277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3K5"/>
    <dbReference type="GeneID" id="28825003"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686413"/>
    <dbReference type="InParanoid" id="A0A194X3K5"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
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            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
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            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
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        <location>
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            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="553" mass="57738" checksum="DB77409E0AD38F9C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3N5</accession>
    <name>A0A194X3N5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_698747</name>
    </gene>
    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3N5"/>
    <dbReference type="GeneID" id="28826730"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698747"/>
    <dbReference type="InParanoid" id="A0A194X3N5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="573" mass="65320" checksum="4BC92A7452AAB16F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3V1</accession>
    <name>A0A194X3V1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_588963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069201.1">
        <property type="nucleotide sequence ID" value="XM_018209507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3V1"/>
    <dbReference type="GeneID" id="28819233"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588963"/>
    <dbReference type="InParanoid" id="A0A194X3V1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22237" checksum="3064281F2756C716" modified="2016-10-05" version="1">MTPILQTPTHTFYLRPAAPPDTPALNTMISLSVRTLHTPFYSAAVIDSAMKYVYGVDSLLISDGTYFLISATPLQSPNQNEEEIVAAGSYSFRSTLYGGDQFSARDPTELDPGKDAARLRAMFVHPSFTGLGLAGVMLRRCEGEVRGRGFRRLEFGATYAGVGFYERAGYGRLEEEGVGGKGRCDKVMEDGRVLELVKMGRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3Z3</accession>
    <name>A0A194X3Z3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_698465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069241.1">
        <property type="nucleotide sequence ID" value="XM_018216982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3Z3"/>
    <dbReference type="STRING" id="149040.A0A194X3Z3"/>
    <dbReference type="GeneID" id="28826708"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698465"/>
    <dbReference type="InParanoid" id="A0A194X3Z3"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="31896" checksum="08520E672CBBE86E" modified="2016-10-05" version="1">MHISASTLPDQNGTIKPTGNGSSFFYTPSNRPPTADQLSPRSSSPDSSAHASDSSESPPPRSLSSSPAAPMLSSSPPLRRRTRIVAEGNFTVEEFADSDYEDWDSDDEDEVIRPHQYEDAESDRAPSVSVKNRNNDLDTMRIVSDFQNLHCENEEERELWLEKLRAEKRRRRRSSASVQKRTLSMSIGSDTDDEDLKPVTFEGANEAGSSARRLRRKVGERTSLIFDDPPPRIEEEDEGPESVEEVVEIREEDEDEDVDRELRELPYWYIQEMDVDSDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X535</accession>
    <name>A0A194X535_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_648509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069646.1">
        <property type="nucleotide sequence ID" value="XM_018212018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X535"/>
    <dbReference type="STRING" id="149040.A0A194X535"/>
    <dbReference type="GeneID" id="28821744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648509"/>
    <dbReference type="InParanoid" id="A0A194X535"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="175"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="322"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="46856" checksum="27E5DA705E1C4DA1" modified="2016-10-05" version="1">MASSSPKIAFLGLGAMGFGMATNLIKLSHPVTGFDVWKPTLERFSAAGGSTATTPRECVRDAPYVVFMVATAAQIMSALFEGPDAAVHELKEGVSLMLCSTGPPEYVPLIQGKLKELGRGDVLVVDAPVSGGTIRAANGTLSIFAAGEEKAVEAAKPILNDMAGSNLWLIPGGLGAGTNVKMVHQVLAGIHIAMTSEAMGFVGKLGLPSKKAFELLKAGEGSSWMFENRTPHLLVEDKTIYSALNIIVKDIGIVTAGGRSAHFPLFLSSTTEQILASGVGAGLGLVDDANLVGVYLPQDPTAILKLASLPEPLAADNAELRLVEKAMAGVHLAAAAEAMCLAAKVGLDAKTMFEIISTAAGASKMFVKKAPLWLSGEWKSGKTVDDVIAELTEAIEEANRLKYPLHLAGTALQLFELASMKGQGKEPDVAIVRIWDGPNGPLYPRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5F9</accession>
    <name>A0A194X5F9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_783560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069761.1">
        <property type="nucleotide sequence ID" value="XM_018222694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5F9"/>
    <dbReference type="GeneID" id="28832420"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783560"/>
    <dbReference type="InParanoid" id="A0A194X5F9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="140" mass="15750" checksum="1F2E346556C840E5" modified="2016-10-05" version="1">MAVRMRDVGAGHVDFLSSPEGLIMLSLDMSSCIPSEGAVLGHKSKLMPLRLQASTKHWSRSRGGFSRLPTISSLYLLLLLSYPHTPRTCLFTTLTVYVQILLLMAQPRTHPRKPRLLLSRLELHAATMLHIPLLLQRRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5T5</accession>
    <name>A0A194X5T5_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_648894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069896.1">
        <property type="nucleotide sequence ID" value="XM_018212034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5T5"/>
    <dbReference type="GeneID" id="28821760"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648894"/>
    <dbReference type="InParanoid" id="A0A194X5T5"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF16">
        <property type="entry name" value="CARBOXYPHOSPHONOENOLPYRUVATE PHOSPHONOMUTASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="27776" checksum="898C5D14AAE2A8A8" modified="2016-10-05" version="1">MSALNQSAQVLKSLHQRPHKPLVLANVYDILTARAVAELPSSETLATASYSVAQAAGTTDNDLTLDENLTAVKGIAAVAKEFNKPLTVDFQDAYGSKLEEGINKLLDLGVAGINLEDYDNTTQQLMDAQTAVDRIRRTLDVAKERNVPDFVVNARCDVLVLGGKMEEVVKRGKSYLDAGATTVFVWGGKRDVSKAEVEHMVKEFGGRLNVSLKRSADGLTIKELADLGVARISMGPALQILAMKAFQDEAAKLFSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5Z1</accession>
    <name>A0A194X5Z1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_735355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069577.1">
        <property type="nucleotide sequence ID" value="XM_018220001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5Z1"/>
    <dbReference type="STRING" id="149040.A0A194X5Z1"/>
    <dbReference type="GeneID" id="28829727"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735355"/>
    <dbReference type="InParanoid" id="A0A194X5Z1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="299"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="830"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="878" mass="100176" checksum="FC63B0539F870B49" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X624</accession>
    <name>A0A194X624_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_685582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069983.1">
        <property type="nucleotide sequence ID" value="XM_018215112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X624"/>
    <dbReference type="STRING" id="149040.A0A194X624"/>
    <dbReference type="GeneID" id="28824838"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685582"/>
    <dbReference type="InParanoid" id="A0A194X624"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25331" checksum="50FE55912EE2AC78" modified="2016-10-05" version="1">MLSSTRSAAALALRVKPASSLISYRSIAAISSSSAKPANAVTSHNVPGSSGTPLMSVTGKERREVPLPSQEGKKGVMQYALTTLDQIANWARQGSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVISMGSCANGGGYYHYSYSVTRGCDRIVPVDIYVPGCPPTSEALMYGIFQLQKKMRHTKITRMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X705</accession>
    <name>A0A194X705_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_783124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070224.1">
        <property type="nucleotide sequence ID" value="XM_018222652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X705"/>
    <dbReference type="GeneID" id="28832378"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783124"/>
    <dbReference type="InParanoid" id="A0A194X705"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="521" mass="57298" checksum="EB1516BA00AA1D28" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X881</accession>
    <name>A0A194X881_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_648107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070357.1">
        <property type="nucleotide sequence ID" value="XM_018211990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X881"/>
    <dbReference type="GeneID" id="28821716"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648107"/>
    <dbReference type="InParanoid" id="A0A194X881"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="501" mass="55738" checksum="B2C457D6EFC63562" modified="2016-10-05" version="1">MDEIHAKNDVELVEAIIKPINQLPLPDELLHLDDEGIQKLEKGLVKRLDWTLMPVVVLLFLLNILDRNNIANAKVAGLPKTLGISDSQYNTCLMIFYVGYVLTQVPSNLIIRKVRPSIYICGITSAWGIISMSQGFTKNFAGLFASRFILGLVEAPFLPGVFLMSCWYKRTELPPRIAFLYGANMLASAFGGLIAAGIIARMEGKLGRPAWEWLFIIEGSMTVVIALLVMPILPDYPLQKASKIISHEQQLFAEWRIRKENAGIRDEDPESILWGLKQALFDPKLYMFIILQMSLITAQSFTNFFPSIVGTLGYNTTITLLLTAPPYLLAFITSLAISFHAAHKYERGWHIAIPMLFALLGNLMAMFVPTLGGRYFSMFLMCAGSYSPYNLCVSWLSASLPRPASKRAASLAIINLMGAGVAHFYTSYAFPDSQKPRYYGGGSMMCAASLVCALMAIGIKYHLKRENARFEREEMGGEVPARTIKASKSDGEAVVSFRYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X894</accession>
    <name>A0A194X894_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_669906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070745.1">
        <property type="nucleotide sequence ID" value="XM_018213134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X894"/>
    <dbReference type="FunCoup" id="A0A194X894">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X894"/>
    <dbReference type="GeneID" id="28822860"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669906"/>
    <dbReference type="InParanoid" id="A0A194X894"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
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        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="815"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="851"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <location>
            <begin position="1032"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="336"/>
            <end position="402"/>
        </location>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ16390.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122622" checksum="1584CB8ABB9F9534" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA98</accession>
    <name>A0A194XA98_MOLSC</name>
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        <recommendedName>
            <fullName evidence="8">Cardiolipin synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_685052</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KUJ17098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11345" checksum="2076272CCD69A07A" modified="2016-10-05" version="1">MIQQILLNLFLVSLAMAEETVSTSQHGNAWKYGTGGGLLGFVILILDIMVFMEVLKSNRPPSHKLLWCVVVFLFPILGLVFYWLFSNREKHMGSGGYEAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAD6</accession>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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    <dbReference type="OrthoDB" id="8120565at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF67">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="49"/>
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    </feature>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="566" mass="61716" checksum="763818BB64AFBAA1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBQ9</accession>
    <name>A0A194XBQ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoic acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_781776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071954.1">
        <property type="nucleotide sequence ID" value="XM_018222512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBQ9"/>
    <dbReference type="GeneID" id="28832238"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781776"/>
    <dbReference type="InParanoid" id="A0A194XBQ9"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="65"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="39241" checksum="9C319571B02C9CAE" modified="2016-10-05" version="1">MLGKIILEEAFALPRLEEKTRWWAGMFSTDPETHVQEIQDLNDLRIKHADKHGVGYQILSYTTPGVQDIWDQKEAQALALEINDFVAEKLKQFPDHLGAFATLSMHDPKEAAAELRRTVTEYGFKGALVNDTQRSGPDGDDMIFYDNPKWDVFWETCTELDVPVYIHPRNPTGTIYEKLWKDRSWLVGPPLSFAQGVSLHVLGMVTNGVFDRNPKLQIIIGHMGEHIPFDMWRINHWFEDRKKLLGLDCKKTIREYFNENIWITTSGHFSTTTLNFCLAEVSSDRILFSVDYPFETFEDGCTWFDNAELNTRDRLKIGRENAKNLFKLEEYKDSDAKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC85</accession>
    <name>A0A194XC85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072129.1">
        <property type="nucleotide sequence ID" value="XM_018213064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC85"/>
    <dbReference type="GeneID" id="28822790"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669063"/>
    <dbReference type="InParanoid" id="A0A194XC85"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="19970" checksum="BF8C03E728FB1939" modified="2016-10-05" version="1">MSPRHSHKSRSNPMDNRSPAASSKLDTKQSPSATPTRVETSTSNSRTESAYGENSHAWTTSSNNSKPVHTASLRLHSIEHPYPQHENVPQYAEQVIFGVSSLGIYIPPYLERTLVDQHGTEYLYSRIEENVELQYWNFSLSGEQAHWEERDDGLSGDLVGIGAQFDSQTSSAYVSSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCI2</accession>
    <name>A0A194XCI2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_707025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071812.1">
        <property type="nucleotide sequence ID" value="XM_018217573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCI2"/>
    <dbReference type="GeneID" id="28827299"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707025"/>
    <dbReference type="InParanoid" id="A0A194XCI2"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="229" mass="25381" checksum="BAB5A3922589C53F" modified="2016-10-05" version="1">MPIRHLLRKPFYFPRPRQILRHQSTSAESRTRARITSLHARLPNFLHPYTCGLLTAPISHLVSFLILHEITAVVPLIGLASLFHYTNWLPEAWVEGRWVKEGVDRFGRYFGRKGWFGFSAQEKGEQGEGGEISVESEENRWRVGERGGRILVEVATAYAITKVFLPARMLLSVWGTPWFARVFVGRFTGLFRGVKGAGNGKGAAGLGASAGGVGGGIGKDLDRVKKMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD50</accession>
    <name>A0A194XD50_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Geranylgeranyl pyrophosphate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_37328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072439.1">
        <property type="nucleotide sequence ID" value="XM_018207069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD50"/>
    <dbReference type="FunCoup" id="A0A194XD50">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD50"/>
    <dbReference type="GeneID" id="28816795"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_37328"/>
    <dbReference type="InParanoid" id="A0A194XD50"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="389" mass="43729" checksum="4DFCC7F05497A44A" modified="2016-10-05" version="1">MYQSNLSQRGPSSMTHDNLRSPNAIPPRTSSTGQNGLNHVASKPVLKPVPEGDWISQRKRSISNMEAVNPTIQPSGGPDPSKYYKNDMAFNGKGSWSATKEKVLLGPYDYLFAHPGKDIRSQFIVAFNEWLEVPAESLEVITKVVGMLHTASLLVDDVEDSSLLRRGLPVAHSIFGTAQTINSANYVYFLALQELTKLKNPKAVSIYTEELLNLHRGQGMDLFWRDTLTCPSEDDYLEMVGNKTGGLFRLAIKLMQAESGKLKDCVPLVNLMGIIFQIRDDYQNLSSPEYSHNKGLCEDLTEGKFSFPIIHSIRARPENMQLLNILKQKTDDEQVKRYAVSYMENTGSFEYCRKVLATLLDRARRLVEELDEGEHKGRGVLKILDKMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE90</accession>
    <name>A0A194XE90_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_497527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072848.1">
        <property type="nucleotide sequence ID" value="XM_018207935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE90"/>
    <dbReference type="GeneID" id="28817661"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_497527"/>
    <dbReference type="InParanoid" id="A0A194XE90"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23041" checksum="F54DF1996A4A19E4" modified="2016-10-05" version="1">MHNEARDEIIEDPRPHLRWDSALAADALQYAQKLAQSNRMAHSSPKERIRNGQICGENIAWNAWGRFTLVDATRLWIQEKSKYRGQKIGSGGDSTWGHYTEIICPNVTRVGLGLTRTRSGETYVVARYNACQTHGSTPYDSRKGNIFKNRRWQPITGGRGHRSGSGAGRERRDLPQGGHQFEIMGLDDFFRDLKAFKDQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF55</accession>
    <name>A0A194XF55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_551198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073180.1">
        <property type="nucleotide sequence ID" value="XM_018208306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF55"/>
    <dbReference type="GeneID" id="28818032"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_551198"/>
    <dbReference type="InParanoid" id="A0A194XF55"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="138" mass="15925" checksum="5C536AD7CA857087" modified="2016-10-05" version="1" fragment="single">TVTCYPSVGGIIMTKHAHSVELDYIGVDHFYTTYRSYNTTEEDEFCMKLRKIGGKWWHSIQDRDDAIDSGLRPVYPDEIEVLFLGWPADGGVWILRLESWYQVNWVLGPIFNALNMEERCKAIELCGGTFVQDPEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGL8</accession>
    <name>A0A194XGL8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073668.1">
        <property type="nucleotide sequence ID" value="XM_018214656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGL8"/>
    <dbReference type="FunCoup" id="A0A194XGL8">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="GeneID" id="28824382"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683199"/>
    <dbReference type="InParanoid" id="A0A194XGL8"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="110" mass="12969" checksum="E11824B408A6288F" modified="2016-10-05" version="1">MFGAFRPTNSLGGGLLWKIPWRLSKFQKARQRKRLRAVDTVVAVVDQALAKKSITTKAVERWKEEMPIEQEMVPKDKYTIFDRKEKKYRKGIHKLPKWTRVSQRVNPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGT5</accession>
    <name>A0A194XGT5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_731782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073738.1">
        <property type="nucleotide sequence ID" value="XM_018219618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGT5"/>
    <dbReference type="GeneID" id="28829344"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731782"/>
    <dbReference type="InParanoid" id="A0A194XGT5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17886" checksum="0797BAC7A5222A3F" modified="2016-10-05" version="1">MPQCTPFFYTPPGFVHPEKNMLKHLKHLVINEVMTTTLVTILAQFECLEEVIIKKKYILRPNGGLIKRRDPVTKKRVAQSQDTTDLEAEWLRSGVEVAAARERNDKELKMATGSHTFKLPELSFVNSRRDWQPTWFFKFRARKAKELTVLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH14</accession>
    <name>A0A194XH14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH14"/>
    <dbReference type="GeneID" id="28824344"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683019"/>
    <dbReference type="InParanoid" id="A0A194XH14"/>
    <dbReference type="OrthoDB" id="3556493at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268237" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="18757" checksum="0F22B86286127491" modified="2016-10-05" version="1">MLASLITTFLILTFSTLSLADSAPFTLTANSTNTTLNGQQAYIYIDPADPYFGLLYFTSDPTIPATTFTLDSSGGHILSHLSNTTSTLSLLEANTNNDAYDETIFFSPPSVVADGQNPPTCHVYAGQLSCEVTSEGDTRLTKTYVCPDGVGYGTIGGSLKIGKVVVEGCEAVGLVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI13</accession>
    <name>A0A194XI13_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074153.1">
        <property type="nucleotide sequence ID" value="XM_018219539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI13"/>
    <dbReference type="STRING" id="149040.A0A194XI13"/>
    <dbReference type="GeneID" id="28829265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731051"/>
    <dbReference type="InParanoid" id="A0A194XI13"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="282" mass="32630" checksum="1DA14A2B3C05217E" modified="2016-10-05" version="1">MAWSPWSSTSSVPRVTEYDLDNSDEACKITPAVPQTLGRVGKQELDFSPMDEIVTFHVGSGDDEKKFIVHKSLACQVSPVWEKAFNRAFIEGQTLSCTLLDVKPNPFTLLVKWIYGRDLDTEATKVMKILSGLSGSAKDDENEKLQKTVDDQDISLIQLWILADRLLIPHLQGDVIKILKSRRAASQWNETESRRKRVSLYRPSYQWFPTVFENTKLDSPLRDYTVHQAVFYLDAKTFQEHPECFPKALLLRYAEFTTERTRRFQDMHVDIRPSRRPIRLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIE1</accession>
    <name>A0A194XIE1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_468004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074350.1">
        <property type="nucleotide sequence ID" value="XM_018207737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIE1"/>
    <dbReference type="FunCoup" id="A0A194XIE1">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="28817463"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_468004"/>
    <dbReference type="InParanoid" id="A0A194XIE1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="543" mass="58576" checksum="194D8C1372D8ABF0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJC5</accession>
    <name>A0A194XJC5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_731444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074574.1">
        <property type="nucleotide sequence ID" value="XM_018219571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJC5"/>
    <dbReference type="STRING" id="149040.A0A194XJC5"/>
    <dbReference type="GeneID" id="28829297"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731444"/>
    <dbReference type="InParanoid" id="A0A194XJC5"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000228">
        <property type="entry name" value="NIF domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="74"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="265" mass="29665" checksum="969711E628EADE26" modified="2016-10-05" version="1">MAENLQTVQISSTTTSVSQAVVSAKKRSPPAKARTQTAREARDEKINPSTASGGIPNPTAKYLAASDVVPQLLPQPQHLLVIIDLNGTLLFRPSRKQPTKFISRPNTAPFLQYCVDTFSVVIWSSAKLENVTNMCDTILTPNLRKKVIAVWGRNKFGLSKQDFDLRVQCYKRLTTVWNDKGIAISHPEYANGRRWDQTNTVLVDDSLEKGRSEPFNLLEVPEFFGNANEQGRILPQVHDYLNYLSMHSNVSACLRDNPFKPLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJD8</accession>
    <name>A0A194XJD8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_682004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074589.1">
        <property type="nucleotide sequence ID" value="XM_018214417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJD8"/>
    <dbReference type="FunCoup" id="A0A194XJD8">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJD8"/>
    <dbReference type="GeneID" id="28824143"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682004"/>
    <dbReference type="InParanoid" id="A0A194XJD8"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116931" checksum="34E275F8C18335BD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJG2</accession>
    <name>A0A194XJG2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_578601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074619.1">
        <property type="nucleotide sequence ID" value="XM_018208952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJG2"/>
    <dbReference type="FunCoup" id="A0A194XJG2">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="GeneID" id="28818678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578601"/>
    <dbReference type="InParanoid" id="A0A194XJG2"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="465" mass="50244" checksum="70478CFAF4E92B62" modified="2016-10-05" version="1">MDTEKKSCDESESTQQPGPKPDTAPDGGYGWVCVGCVFLINAHTWGVNSSYGIFLAHYLASNTFPGATSLEYAFVGGLSISLALLMSPVATICTRRYGTQVTLAIGIAFETAGLLGASWANKIWHLFLSQGVAFGFGMGFLFVASVGVVPQWFDRRRSFANSIATAGSGIGGLIYSLGTNAMIQSIGLGWAFRVLAIVAFTVNTICTLLLRDRNKAIGAVQLAFDAQLFRRTEFLLLLGWGTFSMLGYIVLLFSLPNYARSVGLSAYEASVIGAMLNLGQGLGRPFIGFFSDAFGRLNMASSCTFLAGLFCLVIWIFAKSYGVLIFFGLITGGVAGTFWATVGPVGAEVIGLRVLPSALSIVWIVLAIPCTFSEPIGLELRRTTGDIYLHAQIFTGFMYVAAAICMGLLRAWKVRELQSMALSKEQREQEILDDDAVARPRVPAHATETVVKRKAKVSIWSWQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK73</accession>
    <name>A0A194XK73_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_682265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074896.1">
        <property type="nucleotide sequence ID" value="XM_018214473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK73"/>
    <dbReference type="STRING" id="149040.A0A194XK73"/>
    <dbReference type="GeneID" id="28824199"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682265"/>
    <dbReference type="InParanoid" id="A0A194XK73"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268336" evidence="6">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16342" checksum="E751E4849D14AD60" modified="2016-10-05" version="1">MTWISKSVTGLGLLFLAHACYSAYEHSALHSTSTASLSSTAAHTAITSTSSSLPIDISIETLVAVFTVCLGLVLGTPELRPIQWRVWAGQIEREGEAGFTNIDGQVDKDYVGNPFRVLESRPGFVDIRKQRKEFAEWVREGGGIDEAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKY1</accession>
    <name>A0A194XKY1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_716084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075109.1">
        <property type="nucleotide sequence ID" value="XM_018218246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKY1"/>
    <dbReference type="GeneID" id="28827972"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716084"/>
    <dbReference type="InParanoid" id="A0A194XKY1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="23134" checksum="61B4F6BC5530C787" modified="2016-10-05" version="1">MAQNPAPNPNRFCLQRPRQEDDVRNCHRHYRYLDGVRPGFVLEIERTKEEWAIGEMVSFIPSVPRNQNETYGEYRNYNYTMKLEPDQTRIKVFRESKGTGPSSTEVAYVYLDESQGFRGWFNVGDHNADHSAQHPHQPDPKIVLSTEPARCETCGFYSSWRWRDTDLRVGPYFGRDYCQNSCCRLRRVPADDSEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL49</accession>
    <name>A0A194XL49_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_715211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075258.1">
        <property type="nucleotide sequence ID" value="XM_018218185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL49"/>
    <dbReference type="STRING" id="149040.A0A194XL49"/>
    <dbReference type="GeneID" id="28827911"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715211"/>
    <dbReference type="InParanoid" id="A0A194XL49"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="539" mass="62579" checksum="7599BB33C72BFD26" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLP9</accession>
    <name>A0A194XLP9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_778640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075364.1">
        <property type="nucleotide sequence ID" value="XM_018222224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLP9"/>
    <dbReference type="GeneID" id="28831950"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778640"/>
    <dbReference type="InParanoid" id="A0A194XLP9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268378" evidence="2">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="118" mass="12732" checksum="8D89BD1F1D0D200F" modified="2016-10-05" version="1" fragment="single">RGRLRCSCLLALALSTSSFPLLAVLTSTIQQTTSSQKPIRCPSNDPAPLSPLPEKSSSLPVSPLLIHDRAEGSANSNITCSTPSFKFFLRIQFPIPLLHSLPPSLYLSIFIISLDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XME4</accession>
    <name>A0A194XME4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_778907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075703.1">
        <property type="nucleotide sequence ID" value="XM_018222253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XME4"/>
    <dbReference type="GeneID" id="28831979"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778907"/>
    <dbReference type="InParanoid" id="A0A194XME4"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ21348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="60644" checksum="63ED78C8CC9117B7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XME5</accession>
    <name>A0A194XME5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XME5"/>
    <dbReference type="GeneID" id="28824113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681853"/>
    <dbReference type="InParanoid" id="A0A194XME5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268401" evidence="1">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="81" mass="8943" checksum="E82D34CB4B91D1F5" modified="2016-10-05" version="1">MHLSEAWFFLMVPYLVAALPAQDIGDIVEHDGDCVDCAPPPTTIFLCADSNCGSFIDDSCTSDADCPNETFPRCCRFIFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XML3</accession>
    <name>A0A194XML3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_715304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218195.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XML3"/>
    <dbReference type="GeneID" id="28827921"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715304"/>
    <dbReference type="InParanoid" id="A0A194XML3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="579" mass="65798" checksum="7A2C002CB6E913FD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN05</accession>
    <name>A0A194XN05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative heat shock protein hsp98</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_577551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075512.1">
        <property type="nucleotide sequence ID" value="XM_018208902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN05"/>
    <dbReference type="FunCoup" id="A0A194XN05">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XN05"/>
    <dbReference type="GeneID" id="28818628"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577551"/>
    <dbReference type="InParanoid" id="A0A194XN05"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="922" mass="101993" checksum="8028A592C7BCA67C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNB0</accession>
    <name>A0A194XNB0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_681048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075939.1">
        <property type="nucleotide sequence ID" value="XM_018214197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNB0"/>
    <dbReference type="GeneID" id="28823923"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681048"/>
    <dbReference type="InParanoid" id="A0A194XNB0"/>
    <dbReference type="OrthoDB" id="3561020at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="32291" checksum="489C4BE43F135CD9" modified="2016-10-05" version="1">MATFESSDQEQVYSQGQSLSSGQMPTAFTCFPDLPIELRLRIWTWACFHPRDVHVGVKTVRTITPWTNPSPIGLVDYRYYFSRTSCPLILRTTRESRSEALKRYQLDFGIHTSIERLTCSIPPRIYVNWEADRICIDDDFALYGAEALRDLLLDRKVRSLALTVRDKKTPLLLPPLLRAEHLQDIFLVWDTRRFCPDGDYRSVRNRESYRGNGWEAIRTLLISKWPSMELPSSDFFWHQGDTSGGLQYTEEGSNVTLMLNWPNDRKLPLRQLMPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNW9</accession>
    <name>A0A194XNW9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_681296</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076290.1">
        <property type="nucleotide sequence ID" value="XM_018214257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNW9"/>
    <dbReference type="FunCoup" id="A0A194XNW9">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNW9"/>
    <dbReference type="GeneID" id="28823983"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681296"/>
    <dbReference type="InParanoid" id="A0A194XNW9"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268456" description="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ21935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="132" mass="15422" checksum="FC7A2FA61BAE014D" modified="2016-10-05" version="1">MQVASRLLLVWAVVNTFPFLAKSAGYSSMLIAWSVTEVVRYSYFTFTLSGFQPGIISWLRYNTFYVLYPLGISSECWLIYKAIEPARRVRQEFAWALQLILFIYIPGSYVLFTHMMAQRRKVMRGKQVQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPC8</accession>
    <name>A0A194XPC8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_778428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076460.1">
        <property type="nucleotide sequence ID" value="XM_018222208.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28831934"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778428"/>
    <dbReference type="InParanoid" id="A0A194XPC8"/>
    <dbReference type="OrthoDB" id="10679616at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="901" mass="96897" checksum="C09376D8961C9D46" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPG5</accession>
    <name>A0A194XPG5_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_681394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
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        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ22056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28824009"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681394"/>
    <dbReference type="InParanoid" id="A0A194XPG5"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
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        <property type="entry name" value="Ribosomal_uS14_CS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00253">
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S14"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="56" mass="6465" checksum="036A09688DD1904C" modified="2016-10-05" version="1">MSHESVWNSRPRTYGKGARACRVCTHKAGLIRKYGLNICRQCFREKAADIGFVKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQA2</accession>
    <name>A0A194XQA2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_693768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076728.1">
        <property type="nucleotide sequence ID" value="XM_018216660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQA2"/>
    <dbReference type="GeneID" id="28826386"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693768"/>
    <dbReference type="InParanoid" id="A0A194XQA2"/>
    <dbReference type="OrthoDB" id="3443409at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="53" mass="6079" checksum="F7C435B06BD0B54E" modified="2016-10-05" version="1">MCEYTKNYYIYTSCVDPGAHFFGTSVDGKREHRCPRGPHERYIVVPGHCPLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS39</accession>
    <name>A0A194XS39_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_680948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077219.1">
        <property type="nucleotide sequence ID" value="XM_018214176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS39"/>
    <dbReference type="GeneID" id="28823902"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680948"/>
    <dbReference type="InParanoid" id="A0A194XS39"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="20"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="515" mass="56007" checksum="A71D16008D740FF2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSL5</accession>
    <name>A0A194XSL5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_777073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077650.1">
        <property type="nucleotide sequence ID" value="XM_018222106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSL5"/>
    <dbReference type="GeneID" id="28831832"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777073"/>
    <dbReference type="InParanoid" id="A0A194XSL5"/>
    <dbReference type="OrthoDB" id="3555519at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="37345" checksum="9A7A304930EA591C" modified="2016-10-05" version="1">MASNEDKSQHLFEEFADQAIVQIPSNILTQLVTSVNKLKADVSTLRHENSSLVNQVQDLRDELRGVTHSPFSKLPREIRRLIWKFAMMAPQVHIIGSPSHKQSRVNIVMQACKEAREEGLRLKLPYYRYTCGAPRGVLTSLEYYVNWDVDTFWVPDIQLPVEIVCSRCEPVWNESPLSPCAQPRLIHHCLCRPKHGLYALAMNASRWGEPGQTDFFTGRAIHTPVADLANYYSIQKLYIVINYTEPLTCRNIAFVEPTKQGPTLGEDVSTTTWHAMAEEKMALLEAYKARKILERQAKLDAGERVYSFDDFANWKVPSIEYVEHAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT27</accession>
    <name>A0A194XT27_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_727969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077554.1">
        <property type="nucleotide sequence ID" value="XM_018219217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT27"/>
    <dbReference type="STRING" id="149040.A0A194XT27"/>
    <dbReference type="GeneID" id="28828943"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727969"/>
    <dbReference type="InParanoid" id="A0A194XT27"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="23557" checksum="A6ED2D62158BAC10" modified="2016-10-05" version="1">MDMDMVTAVATSSTSMVMSMATSTAAASAATTAMAMSMGGSTGCKLSMLLNWNTIDACFLFSAFHIRSSFNFFLACLGSFLLVISLELLRRFQREFDRHLQARKSVRQEKEYVLPEEMEEKLLDKGGEGGDLRKERKERLVVVMLEQILRGLIHMVQFSVSYCIMLLFMYSNGYIITSIIFGALVGFALFTRDTLHSPTDDIDDREKACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTQ1</accession>
    <name>A0A194XTQ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_679035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078050.1">
        <property type="nucleotide sequence ID" value="XM_018213797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTQ1"/>
    <dbReference type="GeneID" id="28823523"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679035"/>
    <dbReference type="InParanoid" id="A0A194XTQ1"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268656" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35191" checksum="E66370810F42D2C0" modified="2016-10-05" version="1">MLFSILSVFLLAPSLLDAIPTFSRAAPEIRQIFTFPNNTFIENIRVRFNGELLLTSMSVPTLFEIDPTASTPNASIVYTFPNATGLAGITETVPDTFAIVSATWDLVNTRAILGTIVVWTINLGSTPPIVHRIANVTNSTSFNGIASIPESPNLILAADSAIGAIWRVDLLTGLYGIAFSDPLFTPISTAQGSNLGINGLKIKDGYLHFTDSAQGIYGRVEIDSLGNKIGAVDLIANITASVATGGVYDDFALDRMGRAWIATHPEYVVEVELNGSQEVIANETLLLNPTSAAFGRGSTAEEKTLYVANGGLFAGDDLVDEGVVAVDVSCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTT7</accession>
    <name>A0A194XTT7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_662541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078090.1">
        <property type="nucleotide sequence ID" value="XM_018212652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTT7"/>
    <dbReference type="GeneID" id="28822378"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662541"/>
    <dbReference type="InParanoid" id="A0A194XTT7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="167" mass="18476" checksum="2127D55B7A87ACFC" modified="2016-10-05" version="1">MRFHRERGAANGGGGALQPQTDDRVKRAGGEIREQRHQRDKQPIEANGRRLIGKFNARAPLFIQIIRGERIGEDEDNAFAEMATSSIGARRLQKDKYETDEGREVQSSRESNEKKDTLCGWMDDGAGAGAGATPRDLLRCVCTKPCLEEDEEHSSLAPLAPMGELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTV3</accession>
    <name>A0A194XTV3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_679936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077487.1">
        <property type="nucleotide sequence ID" value="XM_018213971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTV3"/>
    <dbReference type="STRING" id="149040.A0A194XTV3"/>
    <dbReference type="GeneID" id="28823697"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679936"/>
    <dbReference type="InParanoid" id="A0A194XTV3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="61016" checksum="0BDAB0639D3AA24C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVD7</accession>
    <name>A0A194XVD7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_679391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078543.1">
        <property type="nucleotide sequence ID" value="XM_018213861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVD7"/>
    <dbReference type="FunCoup" id="A0A194XVD7">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="28823587"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679391"/>
    <dbReference type="InParanoid" id="A0A194XVD7"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000285">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000294">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="525" mass="56622" checksum="872D76E7577D1758" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVX3</accession>
    <name>A0A194XVX3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_4701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078222.1">
        <property type="nucleotide sequence ID" value="XM_018207751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVX3"/>
    <dbReference type="GeneID" id="28817477"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_4701"/>
    <dbReference type="InParanoid" id="A0A194XVX3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13346" checksum="986974DED11E1B1E" modified="2016-10-05" version="1">MEWGFSRRINTASLLSGLGNSSPLFLHSKLSLLCSSVCHSIIVFIQFKIFLLQFNRDTASHSQINQLASSPCHPSSPATRIAGPESYNASARQAAASATQSWLSRCCSLQRHEILKFPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW14</accession>
    <name>A0A194XW14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_663076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078681.1">
        <property type="nucleotide sequence ID" value="XM_018212685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW14"/>
    <dbReference type="STRING" id="149040.A0A194XW14"/>
    <dbReference type="GeneID" id="28822411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663076"/>
    <dbReference type="InParanoid" id="A0A194XW14"/>
    <dbReference type="OrthoDB" id="5422320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24236" checksum="E59A50D2C9046BD7" modified="2016-10-05" version="1">MAAPVVSSEELASFHATHFSSSAADYFAQHFLGPVDDEHYVENGEEEDDGIGYYEDGVKRTLTDQQIAIFRHSEIQALLRERRHAAEAKDDEIHIEAAAPMIGPVQPEKSNSDLAVKPILGDREMEDGEVGDNTTSDAPTPTSQSSNKNRRPFSKSKAKKADRGKQRGYYKEVVKPDLRKRTWDVVEQGLGSLDYDEGSSNMAPSHPAQRRRITYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWJ4</accession>
    <name>A0A194XWJ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_604497</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078452.1">
        <property type="nucleotide sequence ID" value="XM_018210361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWJ4"/>
    <dbReference type="FunCoup" id="A0A194XWJ4">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWJ4"/>
    <dbReference type="GeneID" id="28820087"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604497"/>
    <dbReference type="InParanoid" id="A0A194XWJ4"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="180"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ24097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="371" mass="40791" checksum="64FA45D465035175" modified="2016-10-05" version="1">MSGTILHLRSELGKALEHRSALTPSTAKALIDAGYTVNVERSPERIFDDEEFEKVGATLVPENTWREASADHIIIGLKELPVEEFPLKHTHVQFAHCYKQQGGWEKVLSRFPRGGGTLLDLEFLTDDRGRRVAAFGYHAGFAGAALALETWAWQLSHTEPFPGVSSYPNEDELIVDVKKAIAAGKEKTGRDPRVLVIGALGRCGSGAVDMCLRAGVPTENVLKWDLAETAKGGPFPEIVESDIFVNCIYLISKISNFVDMKSLDVPDRKLSVICDVSADTTNPNNPVPVYTVATTFTEPTVPVEVKAEPKLSVISIDHLPSLLPREASEAFSKDLLPSLLTLNKWRTTDPWAKAEKLFQEKVASLPNSYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWS6</accession>
    <name>A0A194XWS6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_679394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078547.1">
        <property type="nucleotide sequence ID" value="XM_018213863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWS6"/>
    <dbReference type="GeneID" id="28823589"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679394"/>
    <dbReference type="InParanoid" id="A0A194XWS6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="70" mass="7458" checksum="DD779DAB23E04765" modified="2016-10-05" version="1">MRYSSLVCSIHTAIASLNNSTTSIPQSSRLEEGSECVHDLKPGTKDVAANETCGNCHATTTIADMIVQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1D9</accession>
    <name>A0A132B1D9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_415459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ06200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_415459"/>
    <dbReference type="InParanoid" id="A0A132B1D9"/>
    <dbReference type="OrthoDB" id="3257444at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="588" mass="64591" checksum="FC4A780E9F0C2889" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1L8</accession>
    <name>A0A132B1L8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reduct</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_769751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ06282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="A0A132B1L8">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B1L8"/>
    <dbReference type="GeneID" id="28831559"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769751"/>
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    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF21895">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="303"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ06282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="584" mass="65505" checksum="246AA79061E5AE7A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2V6</accession>
    <name>A0A132B2V6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_743642</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061085.1">
        <property type="nucleotide sequence ID" value="XM_018220965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2V6"/>
    <dbReference type="GeneID" id="28830691"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743642"/>
    <dbReference type="InParanoid" id="A0A132B2V6"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="272" mass="29677" checksum="58FBE4E41A6DF575" modified="2016-05-11" version="1">MKTVLVVGKSSPVAFFVQGSELISNVPGANRGIGLQLIRTFKARGWHTIGSVRPETLNASDPSISDLKETNSDIIQIDYKDEDTVKSAAADLTTKKLSLDVLVNCGGNSHLSSLPKRSISESNSGINVRPLEWHIHGQDDLMERFQVMVVGPFLVAKHFLPLITKDGTGKLIYITSKSGSIGAPDHDGEVIGYRMAKAAANQQVKTLALDFQRDNIPVTTLAFEPGFIKTRLTGWRGRVDIEESCTGMVNIIEKLVPEMSGSFLDWKGETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3E6</accession>
    <name>A0A132B3E6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_712564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060799.1">
        <property type="nucleotide sequence ID" value="XM_018217987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3E6"/>
    <dbReference type="STRING" id="149040.A0A132B3E6"/>
    <dbReference type="GeneID" id="28827713"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712564"/>
    <dbReference type="InParanoid" id="A0A132B3E6"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="35023" checksum="4993F1ECFAF1B71C" modified="2016-05-11" version="1">MSTRPAIVQRNNALVRESLPMPKLEERQVLVKVFNSSLNPTDVQSFDGDAFGDGAVLGCDFAGVVEEVGPSVTQLKVGDKIAALIWGGEIEGLGAYSTYCVADERIAFKIPSGLDYATANSGTSLLVWGGSSTVGAYTIQIAAMHGFNIVTTCSTRNFDVVKKHGAKHVFDYNDPDVVAKIAEAAPDLAYAFDCIGNSISSVMSARAMGDKKGGVICTVRPGKAFTEDVPSNVTVTDVLVFTAFLKPHTYKKIYHWPTHQEDHELSREMYSKIRGWIQEGKLTPQKPRDMGTLSVETLQRGMDLNRKGEVSNEKLCFQVSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3X6</accession>
    <name>A0A132B3X6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_712188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061445.1">
        <property type="nucleotide sequence ID" value="XM_018217958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3X6"/>
    <dbReference type="GeneID" id="28827684"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712188"/>
    <dbReference type="InParanoid" id="A0A132B3X6"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ07090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="35494" checksum="4C2CB6CB4EB08D0E" modified="2016-05-11" version="1">MTGLQAAASFKSKRKSSRRDRSRSPVEESHRDKERERHKHRSKRRRHSPQPELDDPSLYDDTHLPNASSGQYLDPDAAFRESLFDAMADDEGAQFWEGVYGQPIHTYPDVKQGPDGELERMTDEEYTAFVRAKMYEKTHQHLIEEKARRDGAKKERERAAKEGAKEAREADRFRRKVEESLRRGEERKANKAWAEKWNAYIEKWERLEKGVLGSVALASIPWPVESGKRKDIGSKEIERFFLYGPTAGQPTEAQLSKVLKAERVRWHPDKIQQKLGGQSVSEEVMQAVTAVFQAIDTLWGEMRDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Z8</accession>
    <name>A0A132B3Z8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061493.1">
        <property type="nucleotide sequence ID" value="XM_018216438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Z8"/>
    <dbReference type="GeneID" id="28826164"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691942"/>
    <dbReference type="InParanoid" id="A0A132B3Z8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="112" mass="12446" checksum="8B408F8DCBA6AB07" modified="2016-05-11" version="1">MDALGEGYDNSSQSQTTTTHHNGNHSTILWTFPSRSPYYLPISLFLGPMGKTIAGAREQLLSQRRHVVIGKTLHVKMWNTHLHQFAFFSDFIHTGSCYAILGAASWIVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B499</accession>
    <name>A0A132B499_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_631820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061593.1">
        <property type="nucleotide sequence ID" value="XM_018211287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B499"/>
    <dbReference type="GeneID" id="28821013"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_631820"/>
    <dbReference type="InParanoid" id="A0A132B499"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="421" mass="46826" checksum="F93C4FCC20115BCE" modified="2016-05-11" version="1">MSSASRLSELASIISENTKKLEEYLASINHPLPSLDPGAPLALMLPEEITVYQETALDAATELRALLLGPIGILQYQAEHNLLIGLQAINKFKLYDFPPGEERTFAQLADQSGVDEDFVRRMIRQAKTSYIFKEPKPGVVAHSAASSAIGMVPLLSQWLGMVSEELYPAASRSIDAQIKWPGSQEPNQTGFNIAHNTDEPTYKAISADPRRAQQFADAMTLFQHSPGMEPSYFVNNYDWSGVSKVVDIGGSHGIVMQELASKVPTIECVVQDVAKVVEEGKTQVPKEISDRVVFMEHDFFTPQPVKGADVYFLRWIFHNWSDKYCIDILRNLVPALQKGARIIVNEFCVPPPGVLTPFQEKPLRSFDLVMLELFNAKERGGEEWAALFHAADEHFVFKGVQFPKGSKLAIIEACWEGEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5Q5</accession>
    <name>A0A132B5Q5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_702210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062095.1">
        <property type="nucleotide sequence ID" value="XM_018217237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5Q5"/>
    <dbReference type="GeneID" id="28826963"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702210"/>
    <dbReference type="InParanoid" id="A0A132B5Q5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="503" mass="58302" checksum="5BA9D1D5E9BB0DE2" modified="2016-05-11" version="1">MELPLQSGFWVYVTSEQLIALFLAVVSYALIRCVYHLYFHPAARFPGPTIAAISNVWYAYHWLTGKYAMAIEKAFEEYGDVVRIAPNEVAFITLKAASDIYASHTKNQEHFTKTVFVDTGDKYRGVVWETDPTKHRQMAKMIAPTFSMKSIKAKEPIMHTYIDKFVQKMKEFGNEDAGIELKKWADWLVMDISAELAYSRKMNQMEDMKSAPLLEVLWRANYFLMAHQICKKFPLLSPIQFLFVSPSAVLNEIRARKLTTKELEIRIERRGKTTHVDHFDHLLPVGAPMPTAEEKKQLNMNALQMLLGGWEQISSECLGTIMFSLQEHETYKRLVTEVRENFTRYEDITPEALAPLNYLNGALMETLRFMALGTGLPRLSPGAMVDGNYVAKGVCVQYGHFAFTRSPRYFHDPRSYKPERWLPESHPYWEPAFKSDARESFFPFNQGPRVCPGSTLAWHEMRLIIANTLPEQKNIVFDREFTICAMWEKPDFWVRFHPVMRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5Z5</accession>
    <name>A0A132B5Z5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062116.1">
        <property type="nucleotide sequence ID" value="XM_018216335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5Z5"/>
    <dbReference type="GeneID" id="28826061"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691484"/>
    <dbReference type="InParanoid" id="A0A132B5Z5"/>
    <dbReference type="OrthoDB" id="3561261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="310" mass="35400" checksum="01EAF281849DE7C8" modified="2016-05-11" version="1">MPTTISRRRGSTPMLLALPPPKPAKFPRFRDLPAELRLHIWGYALPGPRIILLEHKRKKNSGAATDDLKTVDNLNPRVDRLGFRSDAPPPSILYACRESYAIASKYYTQAFANSRGTSIAETYIDFKEDVLYLGSEWLGAGQMNHGNYQERIEYVLRNELHVDDLSRVENLAIWWDNFHTGPRNLDDYLVMILRQFGEVKSVTIVSKKYCMPGFRDTYPKMHGELKFLDEMTETPGADIKLQGLDIPLSKTWLADQRGDQEYLQAISDIAWNGTTWNVPDISYNIITTPHGEELLLQQARDAKAEEVWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B678</accession>
    <name>A0A132B678_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062270.1">
        <property type="nucleotide sequence ID" value="XM_018220854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B678"/>
    <dbReference type="GeneID" id="28830580"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742676"/>
    <dbReference type="InParanoid" id="A0A132B678"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287922" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="22759" checksum="103AD2B58BAF7C74" modified="2016-05-11" version="1">MKLFDVLLAALAFAGMMFVEATPLHGVERAEHTDYNLPHPIVPLYLNTTYNGVHIEGTGSLDEIFAKVLVEHPGFKLPERNNSTKGNSGIERRYGYGALYCIPVPGWSWVPVNMNTAWSQMNFLMQLGPLQLTIPAFACIPIVLNGNAQVWNLHTINPPFEWYGDLGYQILNNCGGYDAATDLMMVGGQQFDVNGFDLIIRQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6G3</accession>
    <name>A0A132B6G3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingoid long chain base kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062351.1">
        <property type="nucleotide sequence ID" value="XM_018216279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6G3"/>
    <dbReference type="FunCoup" id="A0A132B6G3">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6G3"/>
    <dbReference type="GeneID" id="28826005"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691311"/>
    <dbReference type="InParanoid" id="A0A132B6G3"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="134"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="514" mass="56459" checksum="B9B3E69F96A84535" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6W8</accession>
    <name>A0A132B6W8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_555210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062104.1">
        <property type="nucleotide sequence ID" value="XM_018208358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6W8"/>
    <dbReference type="GeneID" id="28818084"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_555210"/>
    <dbReference type="InParanoid" id="A0A132B6W8"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="385" mass="40297" checksum="4A48919C34D813A7" modified="2016-05-11" version="1" fragment="single">RFRASARVVGCCFVAASAGWHDGCIGALIPYLQVYYGGVSDEKVALVFIGSFTGYILASLLNVTLSNRLGLGRLIVLGACAQGLASAVIAFRPPFIAIAICYAVAGFGLALQDAQFNTYIARLPGAPTKLGVVHAIYGIGALLSPAAATLLMRANLPPPLFYLTNLAWCIASLGVLLLGFGFGGGDFSGRQTEVEADDRVASLKTVVSDRVVWAALMFVSLYTGSETSEAGWIVSFLMRERDGGSMSGYASSAFYTGLTSGRVVLLPLTAVLNDKRAVTLYAALALAMQVVVWTSPVFLVDFIAVAACGFVMGPVYPVTVSLVTKATPHGYHPGALSLMASVGQSGSAFLPFLVGTLAESFGIGALQPVLIAMFALMILLWQLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7N6</accession>
    <name>A0A132B7N6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_765403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062354.1">
        <property type="nucleotide sequence ID" value="XM_018221669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7N6"/>
    <dbReference type="GeneID" id="28831395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765403"/>
    <dbReference type="InParanoid" id="A0A132B7N6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="287" mass="33679" checksum="F07386C40B6DAA14" modified="2016-05-11" version="1">MSTMFEMRFQMLVQRLTVASSDEVSSDLWWAAWLSKMQDLCPYSTRSLNACCTEVQVFRVNIPCFSSRNLIDSSRQATESRPETIDKRQTTTEKQGWADNEMMGGDWGLDNIRARESGGGGWRKGIREYWRSSGSGGKGEAEMDDSTTIRCKPPIRGPRRFYERTNDIERATERYRTSDRHRMSERHRPNDRERTTANDRYRFRHRRVVRCIWGWMTWWTGWWILREECPGVALEIWKNVREKSWSGRVGASKIGMADVRRGTAGRYFGKKGYCFGWERWTEEDSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B868</accession>
    <name>A0A132B868_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_333510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062916.1">
        <property type="nucleotide sequence ID" value="XM_018206809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B868"/>
    <dbReference type="STRING" id="149040.A0A132B868"/>
    <dbReference type="GeneID" id="28816535"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_333510"/>
    <dbReference type="InParanoid" id="A0A132B868"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08742.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="114"/>
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        <ligand>
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        <location>
            <position position="81"/>
        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="35972" checksum="A0C5EED73FC2540B" modified="2016-05-11" version="1">MAPSTIKLNTGHAMPQVGFGLWKVDNATCADTVYNAIKVGYRLFDGACVADYGNEKEAGEGVARAIKDGLVKREDLFLVSKLWNSFHDGDQVEPICRKQLADWGIDYFDLFIVHFPVALKYVDPSVRYPPGWAVDGKDDVQLSNASIQETWTAMEDIHKKGLAKSIGISNFQGSLILDLLRYAKIRPATLQIEHHPYLVQPTLLKLAESEGIAVTAYSSFGPQSFIELEWQKAKDTPVLFEHPVVTKIADRTKKTPAQVLLRWATQRGLAVVPKSNNPERLQQNLKVTDFDLEQADLDAISGLDRHLRFNNPTDVSPPFAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B934</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B934"/>
    <dbReference type="GeneID" id="28816501"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_329411"/>
    <dbReference type="InParanoid" id="A0A132B934"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="600" mass="67038" checksum="6430C8298C670CF4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9G6</accession>
    <name>A0A132B9G6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_676386</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063366.1">
        <property type="nucleotide sequence ID" value="XM_018213582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9G6"/>
    <dbReference type="FunCoup" id="A0A132B9G6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9G6"/>
    <dbReference type="GeneID" id="28823308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676386"/>
    <dbReference type="InParanoid" id="A0A132B9G6"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="90"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="469"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ09011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="792" mass="87969" checksum="363262E813493A2A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9L9</accession>
    <name>A0A132B9L9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_320013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063457.1">
        <property type="nucleotide sequence ID" value="XM_018206705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9L9"/>
    <dbReference type="GeneID" id="28816431"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_320013"/>
    <dbReference type="InParanoid" id="A0A132B9L9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="18496" checksum="A2782E574F336027" modified="2016-05-11" version="1">MIISSRYPISRIPLDRCRERQVSSFRFLWRLQPCLEKGRQRPWQLDRVLQVFEGTCHGLGSLPATSIGATKQGRSLEKQRALGDQARIPTPDNSAPCLLICINCPIGFLPVIQSHLSNAYHMLVHSKEKCCQALDSDIDILNTLSKNYQHYIPKVHLMCRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9R5</accession>
    <name>A0A132B9R5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_676507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063500.1">
        <property type="nucleotide sequence ID" value="XM_018213593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9R5"/>
    <dbReference type="STRING" id="149040.A0A132B9R5"/>
    <dbReference type="GeneID" id="28823319"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676507"/>
    <dbReference type="InParanoid" id="A0A132B9R5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30740" checksum="F6698FAA0B126B36" modified="2016-05-11" version="1">MSPSETASLVLSAVSFAIQLYHLGDQISARFHSTSPDDAELRELSIAILDESDHSKVLSSILCDKGKFGLTDSIFESLDQNNKKILLAVLEQLSGVWTETNEFATAIFERAKIAKPQVTPSQLESGENNDLLPLRHRAEAERLKRQLEIATNLNRRLERRIQTFSWLYSVDGASPAQSIDRLDKIAKDSHAQRLGWSRPAELRQLVLGLRNPNIDRTSLPIPQALEIDGACISGLGTLRDGDLSGMMDRRKVLVEFLPSFQMSGDTSQEATKKGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAL9</accession>
    <name>A0A132BAL9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_724581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063394.1">
        <property type="nucleotide sequence ID" value="XM_018218910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28828636"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724581"/>
    <dbReference type="InParanoid" id="A0A132BAL9"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1675" mass="190317" checksum="28A7704801577D3D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAR5</accession>
    <name>A0A132BAR5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_556007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063718.1">
        <property type="nucleotide sequence ID" value="XM_018208367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAR5"/>
    <dbReference type="GeneID" id="28818093"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_556007"/>
    <dbReference type="InParanoid" id="A0A132BAR5"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ09363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46884" checksum="D67346BF4D7684E7" modified="2016-05-11" version="1" fragment="single">FLALASFKAFKGFVHIMSFYFYTRPAKSPRIPTVTPRDVSVIVSTVGSFEADFQMTVQSILLNQPRELIIATVGVDKAKKAQEAIQDLPRALVGSTIITVDLTMAPNKRSQFISAVGEASGDIICYADDHVLWPTTFLKSALAPFEDAHVGMVGTVKAVERVRTDPWVSFLNYVGCIYLERHNFECTATYNIDGGVFVISGRTGLIRKQIVESRDFRKGFLNEKFKFLLFKSDLMKPDDDNFMTRYCVKNEWKTVFHNHPDACVGTTLGVDKDASGSRKTKFLGQLVRWARTTWRSNLVSLFVDRSCWRAYPWTTYAMFISSFINLAIIYDPLMLVFLYLSRPQTSHFWGAVVILFLSKCVKPIQFMWKHPRDLVWLFWGILFGYLHSLIRLYALFTITNVEWSGRQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB70</accession>
    <name>A0A132BB70_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_599245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063262.1">
        <property type="nucleotide sequence ID" value="XM_018210082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB70"/>
    <dbReference type="FunCoup" id="A0A132BB70">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="28819808"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599245"/>
    <dbReference type="InParanoid" id="A0A132BB70"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="40550" checksum="8A53037E67F2A20A" modified="2016-05-11" version="1">MGAKARSEDPENTLGYVSEPGSKYNFSNEQARNALKQEEFWIGIVIQANATTAMNYAYNEGNTSYDPTGSVHVIYEEGRNALAIDELAYPAMLTFMNSFVLQFAKEKQNSLLTANAGNAAALERQAQSPIPIGFSVYNTAPYVPSTAEAATEIGTIYLIIISFLSVLMFNALNEAMMGKISLLHYYIYRLSLYPILYFFLSLLYLALSCAWQIRFDRFYGASGYVIYWMLSWVSMMAFGLAVENVNNVLGPPFTPVFFVFWVITNVATGFYPVELLSNFYLWGLAWPLRHNLIGSKAILFGTKNLLGLNFGVIIAWVAVSIALQPFTIWVQMRKKKGEVEAHKREVLERVYGKNGDEKSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBH1</accession>
    <name>A0A132BBH1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_690554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063352.1">
        <property type="nucleotide sequence ID" value="XM_018216119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBH1"/>
    <dbReference type="FunCoup" id="A0A132BBH1">
        <property type="interactions" value="999"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BBH1"/>
    <dbReference type="GeneID" id="28825845"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690554"/>
    <dbReference type="InParanoid" id="A0A132BBH1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="212" mass="23307" checksum="252B4DDD3983D57B" modified="2016-05-11" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDAKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHQTYENVTRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTEEAKQFASENNLSFIETSALDASNVELAFQNILTEIYRIVSQKALDNGDSAQASLGAGTNISLSKPADEGASKGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCR9</accession>
    <name>A0A132BCR9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_627847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063999.1">
        <property type="nucleotide sequence ID" value="XM_018211160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCR9"/>
    <dbReference type="STRING" id="149040.A0A132BCR9"/>
    <dbReference type="GeneID" id="28820886"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_627847"/>
    <dbReference type="InParanoid" id="A0A132BCR9"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="585" mass="65967" checksum="8D714991605F241D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCV3</accession>
    <name>A0A132BCV3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative heat shock protein Hsp88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_255504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064617.1">
        <property type="nucleotide sequence ID" value="XM_018206232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCV3"/>
    <dbReference type="FunCoup" id="A0A132BCV3">
        <property type="interactions" value="1500"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCV3"/>
    <dbReference type="GeneID" id="28815958"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_255504"/>
    <dbReference type="InParanoid" id="A0A132BCV3"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10262.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="749" mass="83308" checksum="B3594AE4D2288E73" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD90</accession>
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            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="KUJ10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LtrA"/>
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    </dbReference>
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            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="48"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69417" checksum="F658EEE311DC67BE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT79</accession>
    <name>A0A194WT79_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_238763</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065515.1">
        <property type="nucleotide sequence ID" value="XM_018206079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT79"/>
    <dbReference type="GeneID" id="28815805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_238763"/>
    <dbReference type="InParanoid" id="A0A194WT79"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="118" mass="13834" checksum="D9EFF2B86DB3FF3E" modified="2016-10-05" version="1">MLEGDTWVYSLDLQSNAFREQMGDFWTGVTWKIQLARMDHHYDADLWRIEDEWKPDFIRWHLEQYSICLQISTIPAAWTVAHSPILHYSHGEELETRLARSKPNLLEGGDGTTYNGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTE8</accession>
    <name>A0A194WTE8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_594836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KUJ11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28819550"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594836"/>
    <dbReference type="InParanoid" id="A0A194WTE8"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="736" mass="82799" checksum="A7CC32F26E2CDB37" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUJ1</accession>
    <name>A0A194WUJ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_700237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="34"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="41961" checksum="0AF80B89F477AAAC" modified="2016-10-05" version="1">MAPPFAPPPPPPPPESPLFRHRQLAPTANVRVSPICLGAMNFGDAHKARMGECTKETSFEILDTFKKLGGNFIDTANGYQDGESEQWLGEWLTSRKCRDEMVIATKFSSAYRKHEKEKIQSNFGGNGTKSLHVSVNNSLKQLQTSYIDILYLHWWDYASTIPELMHSLNDFVAAGKVLYLGISDTPAWFVVYQGMWNASMRDFERDIIPMCKDEGMGLLPYGTLGQGRFQTEAAFKEREKNNPGRKGKPKAVERAVSKVMEDLGSTKKTTITSIAMAYVMQKAPYVFPIVGGRKVDHIKGNIDALKVDLTEEDIAKIDGVNRFDFGFPNTFLSGTLFGEEDDTSETPEGPQSVWLTSILGTFDWAIGGKPIRPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWA0</accession>
    <name>A0A194WWA0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_214216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066212.1">
        <property type="nucleotide sequence ID" value="XM_018205888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWA0"/>
    <dbReference type="GeneID" id="28815614"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_214216"/>
    <dbReference type="InParanoid" id="A0A194WWA0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14506" checksum="193F6939B185A281" modified="2016-10-05" version="1">MRNQYHSLSTSPSASEPEHTTSTYPAITIQTPPDKAWTRDECRDWLNKVGVEACHLDPREALAKAQLWDWTSVVLITKSERDLRDILGNVLGMEAYARVYDSTVRFFPGHMYVPSKFPGPIEVSSKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXI1</accession>
    <name>A0A194WXI1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_721577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067046.1">
        <property type="nucleotide sequence ID" value="XM_018218657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXI1"/>
    <dbReference type="STRING" id="149040.A0A194WXI1"/>
    <dbReference type="GeneID" id="28828383"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721577"/>
    <dbReference type="InParanoid" id="A0A194WXI1"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
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            <begin position="206"/>
            <end position="223"/>
        </location>
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            <end position="264"/>
        </location>
    </feature>
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            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12691.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="401" mass="43072" checksum="0EB606A4824C6836" modified="2016-10-05" version="1">MQWNRYIGLVLAITSTMAIGTSFVITKKGLMDAEERHGFEGDGFTYLKSPIWWAGIIALIVGEVANFAAYAFAPAILVTPLGALSVLIGAVLGSYFLKEELGTLGKLGCAICLIGSVIIVLHAPPDKEITTIDEILHYAIQPGFLIFCAAVAVFAVVMIYRVAPKYGKKNPLIFLSICSTVGSVSVMSVKAFGIAVKLTLAGNNQFTHPSTYVFIILTGVCILTQMNYFNKALSQFPTSIVNPLYYVTFTTATLCASFILYGGFNTSDAVNTLSLLSGFLVIFTGVYLLNISRGDPDGRRMINGANHDGIATDPISGIQTRRSMQARRSLDPHRMSMGSNGFGRGGDREGLIHAYDEEENNAGFGLTDLTEDSDDDAPPPSAKTPNGKMNGNGNGNKRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXI2</accession>
    <name>A0A194WXI2_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_592742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28819440"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592742"/>
    <dbReference type="InParanoid" id="A0A194WXI2"/>
    <dbReference type="OrthoDB" id="440104at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="102" mass="12327" checksum="F49812E36A2377D3" modified="2016-10-05" version="1" fragment="single">IFMEDGSKVHKGHARLPRLQHNIRGFNWPPSSPDLNPIEKVWRWMKEELKNLDYVPKNKVDLKRELQKLWDRVDPRDFRHYTEQLTCKIEDVIKYKGMATIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYD2</accession>
    <name>A0A194WYD2_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_622607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067044.1">
        <property type="nucleotide sequence ID" value="XM_018210982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYD2"/>
    <dbReference type="FunCoup" id="A0A194WYD2">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WYD2"/>
    <dbReference type="GeneID" id="28820708"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622607"/>
    <dbReference type="InParanoid" id="A0A194WYD2"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="143"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="356"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="420"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="765" mass="84925" checksum="126524CCB5CB27AA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYS3</accession>
    <name>A0A194WYS3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_200919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067450.1">
        <property type="nucleotide sequence ID" value="XM_018205791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYS3"/>
    <dbReference type="STRING" id="149040.A0A194WYS3"/>
    <dbReference type="GeneID" id="28815517"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_200919"/>
    <dbReference type="InParanoid" id="A0A194WYS3"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="499" mass="54832" checksum="50C701630BF56F94" modified="2016-10-05" version="1">MAESKVALQVCWTCKMGKRKCSKELPSCARCSKLLLKCDYDYNLTEANPQNKQVTSPASSVEGSTLPSLQTASRLMAALSENSPRTIKLEANIPSQVLNVLISNGEGVPSVTSNYFRTIDVWLPVIAPEPCLKRLETITADNNVELASLLLAMFLVTRPPGQNSGIKEMQTPLYFDTKTLYAFLVTFGRSSIEIIQAGFLISLYEIGHGMTEAAQVTMIVTSRLATKTKIRQYRNSSANIANTEFGRLWWGIVTLDRYLNQGLAADEIQLLVGTSNDGVPSMELPTDDETGLPPPISMRTTSGISASNQPTTRLGPFCRASEAGHLLGQVLDLVAESSNTNQMNETKSRALDKNLQELAVVLFQRAINGWEECCAAIGLCLSALVLLHERTWILAKDTIGQETRKQAAGMALSSAIRMVIDISRRFHMDLAFIDLPALPLPATYAVYRTTLLYIQLAGDEFQGSEWSSNMESLKSTLGHFGKRWNVGSKSWNDRGYAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYZ2</accession>
    <name>A0A194WYZ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_721671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067167.1">
        <property type="nucleotide sequence ID" value="XM_018218663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYZ2"/>
    <dbReference type="GeneID" id="28828389"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721671"/>
    <dbReference type="InParanoid" id="A0A194WYZ2"/>
    <dbReference type="OrthoDB" id="3549570at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="56"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="375" mass="41938" checksum="8587B9D77965807B" modified="2016-10-05" version="1">MNPPTLRDLGPVPSPMHSVSDRLARRDNLSFQDIRDLKEERNKLPPRDVKDIAADLAARVKRAPQFRRFIKVEELSMWNLYMLQHKILSMKPDSMRVFQGLDMKSRAMKEMRAWRNHDKNSGAPLGSTTSPITATLEGGAAINSITPAAPLDSSIHKPPLITSTTGPPSTDVPDGLQLLLKQYHESLKAFKEMQTWREASNTSCRIARSDLAFHFCDENYLESEEKMFDLSPTLKLETGGSVDCIRRMLMNYLPLRYVNEDAWNEKRGQLDPGAVPERAQTFSSWRTDFDTPPFVDNLARVLVSLLAGLFLLVPMIVVSFIISQKVRLSVTVALVVRFAVSLGWFGKSTNDALMGTSAAYAAVLVVFVGQTSPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ77</accession>
    <name>A0A194WZ77_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_622047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067613.1">
        <property type="nucleotide sequence ID" value="XM_018210959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ77"/>
    <dbReference type="FunCoup" id="A0A194WZ77">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="GeneID" id="28820685"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622047"/>
    <dbReference type="InParanoid" id="A0A194WZ77"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="10"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="55817" checksum="F48D85B832C4E957" modified="2016-10-05" version="1">MAERKLPVQQLTILALCRFAEPLSMLSILPYLPEMIESFGVAEDDIALWAGVAASLYSACECIAAIPWSILSDHLGRRPVILASLTITMITSLLWGFSTNLTMALTARVLAGLGNGVAGIIRTMVAELCPWKELQPVAFSVMPIVWNLGSIIGPAFGGALSNPYDRLPGTPAGPHFFEKFPYALPNVASAGFFLGGIVIGIFFLKETLPSRKDHEDVALRMGKRLTCRAHEGLRKVRYLFIPGNEDETKPLLSGSSSTMFEPSLGSESNDDILEEEDEDQKGMVTWRDVLSKQSSLNLVAYGLLCMHSMSYDQILPVFMHHPVQNPNDADVSLPFKFSGGFGIDTSQISTLFTLYGVASMFFQFFIFPPCVRRFGTLRCFKACSVVFPIAYFMTPFASLLPGTFSKEAVILLIWFVKGLCTNVAFPSSTILLMNSVSNPRYLARFNGVSVVVSSIGRALGPSIMGPMFTFGVDKGYVIVPFWTLAVITALGVIPVFCLKDPDEMERENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZZ1</accession>
    <name>A0A194WZZ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_687401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067542.1">
        <property type="nucleotide sequence ID" value="XM_018215490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZZ1"/>
    <dbReference type="GeneID" id="28825216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687401"/>
    <dbReference type="InParanoid" id="A0A194WZZ1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="84" mass="9657" checksum="006C9C604E2C3374" modified="2016-10-05" version="1">MFSSNIQALNPRRSHKCGRLKLALPFVYGFVPRSRTKRFARISVVTFLQCPMPNAQLFLTRDDWIILVASALTWVGPHLDKPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X092</accession>
    <name>A0A194X092_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_651562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067729.1">
        <property type="nucleotide sequence ID" value="XM_018212168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X092"/>
    <dbReference type="STRING" id="149040.A0A194X092"/>
    <dbReference type="GeneID" id="28821894"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651562"/>
    <dbReference type="InParanoid" id="A0A194X092"/>
    <dbReference type="OrthoDB" id="4187949at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="64313" checksum="0036C5A870F3C616" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0P8</accession>
    <name>A0A194X0P8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_708919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068120.1">
        <property type="nucleotide sequence ID" value="XM_018217715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0P8"/>
    <dbReference type="GeneID" id="28827441"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708919"/>
    <dbReference type="InParanoid" id="A0A194X0P8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF19">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20522" checksum="A2CF7350D1939ECF" modified="2016-10-05" version="1">MAKQMRDPIQLRYHVLGPFFPGRDGTTIAESNVQFQLAHHPNYWTQLRKQSLKETIRTTGPVARVWRVSLKDTVLPLGGGPDQKMIHNKDVWGDDVEEFKPERWIGRKPMWEFVCFWGGPRLCAAQQQVYTYVIYAMVRLTQRFESIENCDPVYEYVEGLMPSIESVNGVKVAFKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0R2</accession>
    <name>A0A194X0R2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_147116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068130.1">
        <property type="nucleotide sequence ID" value="XM_018205363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0R2"/>
    <dbReference type="GeneID" id="28815089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_147116"/>
    <dbReference type="InParanoid" id="A0A194X0R2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17749" checksum="D7E067F3533B4319" modified="2016-10-05" version="1">MTDPPELLHHEFVEFQFFFPKQALVIPLQIVATVFLIAVNQHLGTKQPPTSYKHNHGHNIIHFDILHLHIHHSPHTNMPRALLPLRPCRVPRAPRRDNSRNHAHGDRVLHSQHGISRTTSRGEDCYCGWRRVDPLISSEKGIGRNVLGLDWCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0V8</accession>
    <name>A0A194X0V8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_699303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067852.1">
        <property type="nucleotide sequence ID" value="XM_018217047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0V8"/>
    <dbReference type="GeneID" id="28826773"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699303"/>
    <dbReference type="InParanoid" id="A0A194X0V8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF78">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="49673" checksum="0B21A4F81728908C" modified="2016-10-05" version="1">MIRLLRLLPHESRNAAIQCQLFNYTLQDSGRRTHPYEALSYVWGDLVNLESISIGGYELPVTQNLYKALSHLRHRSIDRILWVDAVCINQYDTMEKERQIRFMAKIYAQASCVVVWLGECADNSDQALEEIRVAAGGKKSSNQSNLTMIHKAVSSLLQRPWFRRIWVLQEVAAARHVLITCGSAETDGYAFCSGVSLLDFYNNDLDLQSLVRSVIYLIREAIFRPGYATSESGELVDMYHTREATKLHDKVFALLGMSSDDLSKASLSSRYEDPWGKLFQNLTKFLLCDKISTETFGDKQITLIRSKGCILGRVSLVQSDITQGGSQGVEIIFNSISRQMGYKEGSSAHWTLHSLANSIRKGDFVCLLQGASKPTIVRLHDDHFDIIMIAATPPEGMLKLSQSMKPLFRNFLLIWDWEKASREGLKTSWGKLPEHGRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1N0</accession>
    <name>A0A194X1N0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_564565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068453.1">
        <property type="nucleotide sequence ID" value="XM_018208517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1N0"/>
    <dbReference type="GeneID" id="28818243"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_564565"/>
    <dbReference type="InParanoid" id="A0A194X1N0"/>
    <dbReference type="OrthoDB" id="3546995at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="29013" checksum="394EBA466877CB3C" modified="2016-10-05" version="1" fragment="single">VAAFSVIARTIRRLVLFLRLKLDDAFVWFALICLGVACASYFEMIYTIILEEAIAMDPDVIVPINEIAAILSSITYIDIFLCTVWTCTFSVKASFLALFWHLIHGLSKQINTYYWVVVGSVLANWLFLVVEAFILCPEFGEKAVKCYPEDNYFKTLLLTILITVLDVTTDIMIAIIPILILRKSRTKLQQKFSLGIFLCLSFIMVIFALTRVGGLKRGDKVDVTWAIFWQFSEGCVACIMASIVPFRTLFVTLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2H8</accession>
    <name>A0A194X2H8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068755.1">
        <property type="nucleotide sequence ID" value="XM_018215382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2H8"/>
    <dbReference type="GeneID" id="28825108"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686875"/>
    <dbReference type="InParanoid" id="A0A194X2H8"/>
    <dbReference type="OrthoDB" id="4521980at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16804" checksum="6B7D4EB02E0277C7" modified="2016-10-05" version="1">MPHATSPPDTAAIDDWESTPSPDPPNRRTMASDRETQEFISPVPCTWDVPLSKEKIEKLKLGCRPRDMDDKWFVFASEEWNGTVRVHYFRSWTGKKCYELVVEVGDDGDGRVKELVFETRLGDEKEAKEMVFGVSRSVLEVYFGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2X9</accession>
    <name>A0A194X2X9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_137053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068734.1">
        <property type="nucleotide sequence ID" value="XM_018205284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2X9"/>
    <dbReference type="STRING" id="149040.A0A194X2X9"/>
    <dbReference type="GeneID" id="28815010"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_137053"/>
    <dbReference type="InParanoid" id="A0A194X2X9"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="651" mass="72027" checksum="901365AD6A0F68A1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X399</accession>
    <name>A0A194X399_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_671837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068854.1">
        <property type="nucleotide sequence ID" value="XM_018213243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X399"/>
    <dbReference type="GeneID" id="28822969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671837"/>
    <dbReference type="InParanoid" id="A0A194X399"/>
    <dbReference type="OrthoDB" id="10568080at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="30527" checksum="BFEFB077645C7B5A" modified="2016-10-05" version="1">MYFLLELFPASKNLLAQSSSRDSSSASKYKFRLPSTAKRKYLLRRPQNVVYINLKVDILWLTNADLQEFQLMLDKPAEARQHLSGSQLCRRIAVPWKCFDSIFKPIATVNAEHSSLLRSLCRARLQEVMLVLNEHQRSNRDKVVFSPACHRHPILGGVYSFGIFIHSLCKNVDQGLNNTNAEYRRLESPGKTELEILGGKVLETFERTRLQKCKEVQDLRDLGLRPDEFDKELEKKGLIGYEYWKVPAFRFVWACSTSCKEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3P8</accession>
    <name>A0A194X3P8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_122668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069170.1">
        <property type="nucleotide sequence ID" value="XM_018205167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3P8"/>
    <dbReference type="GeneID" id="28814893"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_122668"/>
    <dbReference type="InParanoid" id="A0A194X3P8"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="669" mass="74812" checksum="49E1B69B568BC9C5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X487</accession>
    <name>A0A194X487_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_589139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069348.1">
        <property type="nucleotide sequence ID" value="XM_018209512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X487"/>
    <dbReference type="STRING" id="149040.A0A194X487"/>
    <dbReference type="GeneID" id="28819238"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589139"/>
    <dbReference type="InParanoid" id="A0A194X487"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="132"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="34257" checksum="57992CC29519E8A2" modified="2016-10-05" version="1" fragment="single">LLATQPAIVSTLSNATNITILAPNNDALSAFLNSTAGMVAASDPGAVAALLTYHVLQGNYASSAFMNTSMFIPTALSNTTYANVTGGQRIEARLNGSSVDIFSGLLQESMVVTPNISFTGGTIHIISSVLALPTSPSNTATSLNLTSLAGALTQADLVSTVDSLTDVTIFAPSNEAFSSIGSLLGNLTTEELTGILTYHVVNGTVGYSTMLTNTTLKTVGGGNVTIRVQDDGVFVNEAKVTVPDVLVANGVVHVIDGVLNPNNTSIAPPTSGASTTSAAFTGASSVSSVPFTSLVTPSTTVTSIPTRAPTSSSSSAGAAMMTGAVGMGALFGAAVGVMGVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4N7</accession>
    <name>A0A194X4N7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_588691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069142.1">
        <property type="nucleotide sequence ID" value="XM_018209494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4N7"/>
    <dbReference type="STRING" id="149040.A0A194X4N7"/>
    <dbReference type="GeneID" id="28819220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588691"/>
    <dbReference type="InParanoid" id="A0A194X4N7"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF82">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="4">
        <location>
            <begin position="337"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="683" mass="77029" checksum="88B8E96D0E28D4F4" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X577</accession>
    <name>A0A194X577_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_649551</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212067.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28821793"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649551"/>
    <dbReference type="InParanoid" id="A0A194X577"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:defense response"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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        <property type="entry name" value="RBOH/FRE"/>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_8"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GP91PHOX"/>
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    </dbReference>
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            <end position="82"/>
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        </source>
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        </source>
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    <sequence length="582" mass="66843" checksum="08CB87053B2A593A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6H4</accession>
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        </recommendedName>
    </protein>
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    </gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <end position="22"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35734" checksum="3887FEF5BCB9B827" modified="2016-10-05" version="1" fragment="single">MKPQTFLPLFSALFSLSSLAVALPPPHKTTTNSSIPQTIYEFGNDTWVENLAVRHNGKVLTTILSPLPQVWQIDPFTRTGELIYQFPDVTGVAGITEVEPDIFAVAVGNFSLETFKGTLGSYSIWSVDFSKKEVEVKKVTDMPDAQFLNGMTTLPTQEHTVLIADSFLGVMYHLDVVTGAYSVAIDNPDFKFNASDSIQLGINGIHYRDGFVYFTNTFLTPLIARIPVHANGSASGPVKPISSNFTTPDDFALDRHGNAWIATDPSNSLVKVTLDGEATVVVGGADETVLLGGTSAAFGRTVEDWEVLYVTSNGGLGNPPASGVQPGRLYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6Y6</accession>
    <name>A0A194X6Y6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_734995</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6Y6"/>
    <dbReference type="GeneID" id="28829686"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734995"/>
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    <dbReference type="OrthoDB" id="3547780at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="450" mass="49909" checksum="4497720C32E74944" modified="2016-10-05" version="1">MPIPEALLITNTTLSITVKAFTTCQQAYSLVRGIKDAPKHIQRLSTDILGLYQVLGLLQTALTNDNGQNAQLPRQMVQDLEALLDTCTQLSIDVMTVVNPLLTAGGEVKGGIWKSISWELFKKNDLVNLQQTLATCKLTINMAISALNFVTGNQTNTALEQIQKEVAQIRDVQERQANVEQAESISSTEAVCRFSVASYNLPLRRFLEETESLLDPDASSLSDTSFRPSGGSPIDTGLPDNSWQQFDGISQKRTPFNHHDGWSNRYVQYIAACSPSQINFQSARSISGTMSSQQSRGPVESANKLPCTEPSCSASFTREDDLRRHFEFKHSGTFTYHCPFSTCSLDCPTPCQDPQHHCTFTQPRIDKMKRHFEEVHPSTASGDFGESLSWFYSKTRDMISLRCVTCGESLGNREASSKAIVEPPSFCEVCFCIDSLEDLLSSDENLFAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X730</accession>
    <name>A0A194X730_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_750088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070335.1">
        <property type="nucleotide sequence ID" value="XM_018221187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X730"/>
    <dbReference type="STRING" id="149040.A0A194X730"/>
    <dbReference type="GeneID" id="28830913"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_750088"/>
    <dbReference type="InParanoid" id="A0A194X730"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="370"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1145" mass="123132" checksum="CC3781106FC696A1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X772</accession>
    <name>A0A194X772_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_99197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070284.1">
        <property type="nucleotide sequence ID" value="XM_018223563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X772"/>
    <dbReference type="STRING" id="149040.A0A194X772"/>
    <dbReference type="GeneID" id="28833289"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_99197"/>
    <dbReference type="InParanoid" id="A0A194X772"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25464" checksum="3BEE471D034746C2" modified="2016-10-05" version="1">MNWQFLAFAAGSERLTVADMTLDFPDTSSSKSTSTQTAHQISGSDLSVSDIESSISFQCTEVGAEKIEFSNSPQNASSETSFRTSSILKWWLPEIVASTLSVATLFSLALILRLYEKRNITDLRLLSSLTLNGLIAVISTLNRVLLMVPVGSILSQEGWHWFAEKDQRKRCKSSLGDLDALDQAARGAWGSLIFLFCSRLRQVSETSDTIDADIWEVGIPWPLLSLVYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7A7</accession>
    <name>A0A194X7A7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Breast carcinoma amplified sequence 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_647590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070047.1">
        <property type="nucleotide sequence ID" value="XM_018211966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7A7"/>
    <dbReference type="STRING" id="149040.A0A194X7A7"/>
    <dbReference type="GeneID" id="28821692"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647590"/>
    <dbReference type="InParanoid" id="A0A194X7A7"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21955" checksum="4F7FA982C7F29D44" modified="2016-10-05" version="1">MPLTNAIHESLPYIDAEPTPAQRSAAQALISQELGSQPQDHHLSLPPLLPSTLSPAMEAELQRASTGEKLSSIDTTRYESLSSPATASTLRSAYISQTYLSSRLTNLSLLEKYGKNAWLVSNSQLEDILRGLERELEERKKEIDLVVVERKGAQEAVGGEMKGYEEAWKRGVGRVLETEVAAEGVRREILERRREGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7H0</accession>
    <name>A0A194X7H0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_74967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070466.1">
        <property type="nucleotide sequence ID" value="XM_018221178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7H0"/>
    <dbReference type="GeneID" id="28830904"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_74967"/>
    <dbReference type="InParanoid" id="A0A194X7H0"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="22062" checksum="64814231C5589FD6" modified="2016-10-05" version="1">MDPTPKPLSKGPSPIVLRGSCLCGMIHLESKMLPESITICHCLECRKASSNPFLTFGLFHNDFIQWYMAQPHGSRKDLHGDLSKGIKLTYYSDIATRGWCPRCGTPLFMKYHCRPDGTSITMGLVDDEHIVGSMPPVKEHIFLGDKAVWWNVPLDDGTARYQGFNEPFTRRLLEWSAKGRPQRLDMPPAPSKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Z9</accession>
    <name>A0A194X7Z9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_78011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070594.1">
        <property type="nucleotide sequence ID" value="XM_018222356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Z9"/>
    <dbReference type="GeneID" id="28832082"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_78011"/>
    <dbReference type="InParanoid" id="A0A194X7Z9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="252" mass="27468" checksum="4FAAFB20224D7930" modified="2016-10-05" version="1">MTILSPKDDEQFILHLISPSHTSRYPKTNMTPPNKDPPHKRTYFCTLAIISLDSAGSKHTSTPLPPHQNPIALGATARCFIQLSALSISAAAGEDGLRDQGVCLDHMLKQSDAVAIVCDTGDGLGWKFAREVYFYIVESVNFGGTGEELVVFLVGRDGGGDPFADPEEDGFEGVEKEVGRAEGEEFAREVGVRFLECGGDGNEVVEEIVRVIVGIKGEREGDEGDEEEKVDVEEISGRRWWRKIITGCGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8I9</accession>
    <name>A0A194X8I9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative magnesium-dependent phosphatase P8B7.31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_586365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070848.1">
        <property type="nucleotide sequence ID" value="XM_018209363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8I9"/>
    <dbReference type="FunCoup" id="A0A194X8I9">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8I9"/>
    <dbReference type="GeneID" id="28819089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586365"/>
    <dbReference type="InParanoid" id="A0A194X8I9"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="201" mass="22811" checksum="8DA05322715CBA07" modified="2016-10-05" version="1">MGQGAAPAESTLAPPETFTDGALPKMIVFDLDYTLWPFWVDTHVTPPLKASAAHDSAKDRYGENFAFYSDVPSILYNLRERGIKVGAASRTSAPDLGREMLRLLHIQEGSEGKKRKAIEYFDHLEIYPGSKITHFTKLQRATGFRYEEMLFFDDEARNRNVESLGVTMYLVRDGVTRQEIDNGIRQWRKRHGHDSGRSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8S8</accession>
    <name>A0A194X8S8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">LY89DRAFT_85296</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070874.1">
        <property type="nucleotide sequence ID" value="XM_018223462.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8S8"/>
    <dbReference type="GeneID" id="28833188"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_85296"/>
    <dbReference type="InParanoid" id="A0A194X8S8"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000019">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000055">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
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    <sequence length="1860" mass="205651" checksum="4EA747991BA5463B" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9U1</accession>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA14</accession>
    <name>A0A194XA14_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="13 14">
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
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    <dbReference type="GeneID" id="28828163"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="62"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="835"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="906"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="964" mass="107580" checksum="0DDD0363107B50EC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBQ8</accession>
    <name>A0A194XBQ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_696958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216870.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28826596"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696958"/>
    <dbReference type="InParanoid" id="A0A194XBQ8"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27699" checksum="AA767B6B98204194" modified="2016-10-05" version="1">MAPPLEDVRPKFELKNRSYIVTGGAQGIGFACARAICEMGSNVVIMDIQDQPVEEYKGLSSKFGVRTEYIKTDVTIKESLNSSFAKAIEILGSLDGLVPCAGIAIDKPFTEQTWAEMTRIQELNVRGVFFSELIASQCAHVAIPGYRMAAYNASKGAVRMLAKALAVELAKWKIRVNTISPGFIDLDMTKAVRDLKNAIEGEQMWKSPPLKRIGTQNDLTGAIIYLLSDASSYTTAVDIPIDGGVQAGRIYVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC18</accession>
    <name>A0A194XC18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PLU-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_733541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072064.1">
        <property type="nucleotide sequence ID" value="XM_018219812.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XC18">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XC18"/>
    <dbReference type="GeneID" id="28829538"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733541"/>
    <dbReference type="InParanoid" id="A0A194XC18"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000010">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000322">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
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</entry>
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</entry>
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                <person name="Mondo S.J."/>
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        <source>
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        <source>
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</entry>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="72"/>
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        </location>
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        <location>
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        <location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="733" mass="79855" checksum="86D6529E9839E2A7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE55</accession>
    <name>A0A194XE55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_583061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072781.1">
        <property type="nucleotide sequence ID" value="XM_018209194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE55"/>
    <dbReference type="FunCoup" id="A0A194XE55">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XE55"/>
    <dbReference type="GeneID" id="28818920"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583061"/>
    <dbReference type="InParanoid" id="A0A194XE55"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="20632" checksum="7D7A9292BC3F8A73" modified="2016-10-05" version="1">MPEKKRSRKGRPRVPTGGSARGTTIVWGDYGLRMCDHHRRVSASQLKNGEDAIKVRLKGMRYRLYKRVCASIGVYSSGNEVRMGKGKGSFDHWASRIAVSKVIFELKGDIHEQVARDAFRLAGNKMPGMYEFVKKGDPPVVGITKLDGVTMEELKRPRRKIPLGSIPAGLISETTSTTVSTSTSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XET7</accession>
    <name>A0A194XET7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_502650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073060.1">
        <property type="nucleotide sequence ID" value="XM_018207979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XET7"/>
    <dbReference type="FunCoup" id="A0A194XET7">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XET7"/>
    <dbReference type="GeneID" id="28817705"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_502650"/>
    <dbReference type="InParanoid" id="A0A194XET7"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="5">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="30775" checksum="F61ABD82457F629D" modified="2016-10-05" version="1">MEVGENGENGTNGEMQEHEVAVGPAEEIELGREEKRDVNSEDYLNSKLKFEDDKLLDGDANGVMMAWETGIMRKTVDLLIPDLKPGARVLNIGFGMGIVDRMFRDTKPKSHHIVEAHPAVLEKLSEEGSDFGKAWEESAPEGGKYTVHAGKWQDVCPKLLEEGEVFDAIYFDTFGEDYSQLKHFFTELVPGLLDGDGRFGFFNGLGADRRVCYDVYCRVAELDLCDAGMDVDWTDVEVPVEGMEKEGEGEWKGVRRRYWTLDKYRLPICTFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFI9</accession>
    <name>A0A194XFI9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_582099</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072892.1">
        <property type="nucleotide sequence ID" value="XM_018209143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFI9"/>
    <dbReference type="STRING" id="149040.A0A194XFI9"/>
    <dbReference type="GeneID" id="28818869"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582099"/>
    <dbReference type="InParanoid" id="A0A194XFI9"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268167" description="beta-glucosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="762"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ18537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="840" mass="90059" checksum="D330D251688A608C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGC0</accession>
    <name>A0A194XGC0_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_731650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219590.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28829316"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731650"/>
    <dbReference type="InParanoid" id="A0A194XGC0"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="11076" checksum="3A0B0612AAD4D876" modified="2016-10-05" version="1">MGIRRLRYSDEGIRVWPVRCRHTFAVVLVTAFATAGHTHAVELWYRTQASKPAHDGVQPTESDETVNRGLSPRKLEGSLQTFGDWQMGTSCVTADALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGP8</accession>
    <name>A0A194XGP8_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_489373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073730.1">
        <property type="nucleotide sequence ID" value="XM_018207883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGP8"/>
    <dbReference type="GeneID" id="28817609"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_489373"/>
    <dbReference type="InParanoid" id="A0A194XGP8"/>
    <dbReference type="OrthoDB" id="3518308at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="43696" checksum="DC8E5C74177952A1" modified="2016-10-05" version="1">MEVPKYPRFSAPEMKELAIEWALRTGEDQLVIYDLPKSSLENMTMLDTDNLDMNMLDSAFLTGSSSTLDFKHEEREEKRLIFLRSLMKQCFSRDITLKMETMKLLDEEIESLGLSDSLHNSAFKEKAFAVAKARLSAKHFGTKNLTLKSIKRFDYQVALGVLRGGHGGHYEILDLYFDFKNKFWFFLEILQETTQFSMIPPINLEEQQDDGEEVDFSSSTTSQDSVPSSISSSGSLTSTRTMSESTLRSRSSLNSTPQPDQDTGAVKRRGYTLEHGPWLYRISEQGRSARAKRGAWHNITSLASYNKMIIQFQEHSHSHEGKPPIVSIIHYLDKVAVAQWSRIRANEERAEREFLKLIKESGFDDEDIGEPFMKGGRLFTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIN5</accession>
    <name>A0A194XIN5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_779947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074450.1">
        <property type="nucleotide sequence ID" value="XM_018222342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIN5"/>
    <dbReference type="STRING" id="149040.A0A194XIN5"/>
    <dbReference type="GeneID" id="28832068"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779947"/>
    <dbReference type="InParanoid" id="A0A194XIN5"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="655"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116814" checksum="BDF20E18ECF764FD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJA6</accession>
    <name>A0A194XJA6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_612396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074559.1">
        <property type="nucleotide sequence ID" value="XM_018210616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJA6"/>
    <dbReference type="FunCoup" id="A0A194XJA6">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJA6"/>
    <dbReference type="GeneID" id="28820342"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612396"/>
    <dbReference type="InParanoid" id="A0A194XJA6"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="20129" checksum="212B08DABBC2E5CF" modified="2016-10-05" version="1">MRSQPNIIVTGTPGVGKTTHCESLAESTGLKHLSINNVVKERGCHDGYDDEFKSWIVDEDKLLDAIEDEVKQGGYIIDWHACDLFPKSWIDLVVVLRVDSTLLYDRLKAREYPEAKLQENLDSEIMEVLLQEARDSYDEEIVVELTSNTSDEMESNVERIEGWIKQWKKDNAAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKS1</accession>
    <name>A0A194XKS1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_452500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075049.1">
        <property type="nucleotide sequence ID" value="XM_018207619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKS1"/>
    <dbReference type="GeneID" id="28817345"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_452500"/>
    <dbReference type="InParanoid" id="A0A194XKS1"/>
    <dbReference type="OrthoDB" id="3509578at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="123" mass="13441" checksum="46CB75272E7EE6D7" modified="2016-10-05" version="1">MQFQTPLRRLQFQPLAARLLTQLPSSLAIARNALAEFDIVWWFLSFGLPTISYTAYGNWGTCYNIPGLFGVETGSIKPESGSPGCWVYPKTNCVGNYTVIGPKGDDIWDGSSGSFICDPPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMK8</accession>
    <name>A0A194XMK8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_681639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075362.1">
        <property type="nucleotide sequence ID" value="XM_018214341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMK8"/>
    <dbReference type="FunCoup" id="A0A194XMK8">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XMK8"/>
    <dbReference type="GeneID" id="28824067"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681639"/>
    <dbReference type="InParanoid" id="A0A194XMK8"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="116"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="350" mass="36489" checksum="EBF8AA3A0DF34E3A" modified="2016-10-05" version="1">MSAVASKNLYELLGNDHDEDSDKEPEPPVKVVDKPVARTNKRNAPAEAPASKSATPPQARGGRRGGFAGNEGAFRDRNAGSANNRSKPIEDGVQQDRPPRAQGTYDGRGRGGRSRGGGNYDRHSRGVGGESEKQAAHGWGATEGGAELADEQAGEAIANAEQKEALTGDGEAAPATESAEPAAEPEPEDNSISYADYLAQQAEKKLALGAGVPEPRKPNEGSKQDKKWANAKAIAKEEEEDFVAGSGGKAKRERERKQKQVLEIDQRFVEAPERGGRGGFRGGRGEGRGRGGRGEFRGGRGDGRPRGGRGEGGPPRGDGRAPRGSGGSAPRGGAANLKIEDTSAFPSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XND3</accession>
    <name>A0A194XND3_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_380064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076011.1">
        <property type="nucleotide sequence ID" value="XM_018207123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XND3"/>
    <dbReference type="STRING" id="149040.A0A194XND3"/>
    <dbReference type="GeneID" id="28816849"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_380064"/>
    <dbReference type="InParanoid" id="A0A194XND3"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="38654" checksum="0A0C3663A32B74D8" modified="2016-10-05" version="1">MASVTMSTFVALPKVKLKQLVGTFEPSIELLNKLRGLLVPSPTTSQKVTSAKYSAHLPLQPNRRQSQSVCYDGGTDLVYPSSITRSEPRDIRAVKAHRSPRHSPKRTRTTRQVSHVLPRLVHDNVLDPWDILPGEREGYAITFTSSVTLESLIHSSSRIPSEDADSYFKQAILGLEYLHRSNVAHQDLRPENLIITVNNVLKISNFEKAHYSGPSSKSQQVPRRNSCSTPEYVAPEVFVNSSYDAQAVDMWAMGIIYIEMRRGKLLWIVAAEGADECYDRYLQERVSLWGYRPIENLNNEHCGRVITSLLDPAPAQRYTASRVLKSTWCSAIKPRIPNINETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNQ4</accession>
    <name>A0A194XNQ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_729292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076146.1">
        <property type="nucleotide sequence ID" value="XM_018219366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNQ4"/>
    <dbReference type="STRING" id="149040.A0A194XNQ4"/>
    <dbReference type="GeneID" id="28829092"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729292"/>
    <dbReference type="InParanoid" id="A0A194XNQ4"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF37">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="254"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="585" mass="67644" checksum="84E4B57E5882ADA5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNU8</accession>
    <name>A0A194XNU8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075762.1">
        <property type="nucleotide sequence ID" value="XM_018214402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNU8"/>
    <dbReference type="GeneID" id="28824128"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681913"/>
    <dbReference type="InParanoid" id="A0A194XNU8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="660" mass="74099" checksum="068C2E50126A8A21" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP12</accession>
    <name>A0A194XP12_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_389054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076278.1">
        <property type="nucleotide sequence ID" value="XM_018207172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP12"/>
    <dbReference type="GeneID" id="28816898"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_389054"/>
    <dbReference type="InParanoid" id="A0A194XP12"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268521" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11160" checksum="DC2FC5F401A6031B" modified="2016-10-05" version="1">MWTIALLGLPHICIIPSCLMQFITKATLMTLLSCYSSKAASSVRENATQCMIYHRPMLYISQNKRQRACTFNNRYSSLCYACKCAVHDPFDAELQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP46</accession>
    <name>A0A194XP46_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_715024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076375.1">
        <property type="nucleotide sequence ID" value="XM_018218174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP46"/>
    <dbReference type="GeneID" id="28827900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715024"/>
    <dbReference type="InParanoid" id="A0A194XP46"/>
    <dbReference type="OrthoDB" id="3564606at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="32405" checksum="BCE0A5A9D13675EF" modified="2016-10-05" version="1">MVRPQETQSAPASPSSRSRFRFESATTSFDDLDLPPTSSTSTTEPIFCCPIHSQTLKQDGFHDFVQEQSGCPLFDGSVRSIGADWVHVIAVTPTSKHANPNTLKKQTRYFANLESVSEYQEIDSILYTYLLETSEWDETTTKDRFTCPVHRQTYQLGRQDRLIVDDKSSELLDILATPVLSPSAITTEGYGDSRPVLSPSRLSLEKRRFMIRKLSYGRKDQIQEIIKKATIQDKDQELRESWRLYRATEQEKKKAMEEKLDFEVRYCLAGMRMFFFDRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP76</accession>
    <name>A0A194XP76_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytoene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_704712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076321.1">
        <property type="nucleotide sequence ID" value="XM_018217399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP76"/>
    <dbReference type="STRING" id="149040.A0A194XP76"/>
    <dbReference type="GeneID" id="28827125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704712"/>
    <dbReference type="InParanoid" id="A0A194XP76"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43418" checksum="837332D7011ED896" modified="2016-10-05" version="1">MYSTRASIRLGRCTKFRPASRCNYATTPYSTPAPYTSRITDADVHAARTYCSGLLQKYDSPSYTLQTFVPPSARDAYLSIRALNVELARIPELVSNPTVGALRMQFWRDNLTRTFANTPPKEPVAILLHHALSSLQSRHPGISTSVMKGWFMKVVNGREQYMDNRPYTNLDALETYSENTYSTLMYLTLAALPMHSMAADHVASHIGKATGIAAVLRGLPLLAFPPPPNHHSNNAAFGGALGGSTGGRQGAVVLPLDIMAEAGVKEEDVFRQGADAPGLKDAIFRVATRANDHLITAREMLKNLQQGKDAGHDFEHEGEEGHQYAEMSPKDHSQADELERGFGVLMPAVATRLWLEKLEKVDFDIFRSELRAREWRLPWKAYWAYSRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPU8</accession>
    <name>A0A194XPU8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_704834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076541.1">
        <property type="nucleotide sequence ID" value="XM_018217409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPU8"/>
    <dbReference type="GeneID" id="28827135"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704834"/>
    <dbReference type="InParanoid" id="A0A194XPU8"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="218"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="720" mass="81898" checksum="010C466056D2DB63" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ56</accession>
    <name>A0A194XQ56_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_714905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076232.1">
        <property type="nucleotide sequence ID" value="XM_018218165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ56"/>
    <dbReference type="GeneID" id="28827891"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714905"/>
    <dbReference type="InParanoid" id="A0A194XQ56"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="64"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="515" mass="57564" checksum="EDE041DEE9AD506B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQA6</accession>
    <name>A0A194XQA6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_575434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076733.1">
        <property type="nucleotide sequence ID" value="XM_018208790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQA6"/>
    <dbReference type="STRING" id="149040.A0A194XQA6"/>
    <dbReference type="GeneID" id="28818516"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575434"/>
    <dbReference type="InParanoid" id="A0A194XQA6"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ22378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="20371" checksum="5E6E66BE65CC88CA" modified="2016-10-05" version="1" fragment="single">KSTYAPNQTLYITNLPSSKIQKPDLRIALYMIFSTYGPVLDVVALRTTKMRGQAHIVFRDAQTATQAMRALQGFEFFGREMQIQYAKSKSDTIAKLDGTFRMPAAAAGAVTATELQQSIFNAPPSAATTTNTTAPALGTLKPPSTDHAMEDARSPTTSVAGQKRRRDEEDESEEDSEGDVAMDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR17</accession>
    <name>A0A194XR17_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_575612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076951.1">
        <property type="nucleotide sequence ID" value="XM_018208795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR17"/>
    <dbReference type="STRING" id="149040.A0A194XR17"/>
    <dbReference type="GeneID" id="28818521"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575612"/>
    <dbReference type="InParanoid" id="A0A194XR17"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="42692" checksum="5F79A58A07A5E001" modified="2016-10-05" version="1">MRRSAFRTTVARAIHPQPRRSLNQTTSRCRPELTFSTTVDADNPVPQRRLPPFRFETGLALFAKRAPRPFPPPFLSPPSGSFSDPLSTHHRSRDRRSFVNGELIRGYTNGDDAVYASDQFIGANDGVGAWSTRPGGHAGLWARLILHFWALETEKDIERSRSPDDAYEPMPVDYLQKAYELTIEATSEPNKWQGTTTATGAQLHFQKSESDPNAPATPILYVTNIGDSQVLVLRPKDSERIYKTTEQWHWFDCPRQLGTNSPDTPRDNAVMDKVEIEENDVVLAMSDGVIDNLWEHEIIENVVESIRKWENGQGGEATGDRQGGAGGGMKFVAEELMKAAKVVATDPFAESPFMEHAVEEGLAMEGGKLDDISVVAALCRRNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRJ3</accession>
    <name>A0A194XRJ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_763364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077265.1">
        <property type="nucleotide sequence ID" value="XM_018221596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRJ3"/>
    <dbReference type="STRING" id="149040.A0A194XRJ3"/>
    <dbReference type="GeneID" id="28831322"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_763364"/>
    <dbReference type="InParanoid" id="A0A194XRJ3"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="675" mass="76390" checksum="A5C57CFCECFBA66D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS47</accession>
    <name>A0A194XS47_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077373.1">
        <property type="nucleotide sequence ID" value="XM_018213950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS47"/>
    <dbReference type="GeneID" id="28823676"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679838"/>
    <dbReference type="InParanoid" id="A0A194XS47"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="428" mass="48728" checksum="33479E7BC4C2FAAE" modified="2016-10-05" version="1">MSYLKLPLPPSTVDDGEYILVDDPSSDETSGMGDFKSVNPDDTLYDDDSSSDDSCDFDNISTTTSIIDDFEPDLEDIESDPQVIEAAKQAIGLSNVNTYQFQLFIHFNMLQALFICSGEKVRNEIRKCMHNLMASYPTLFGEVFRSLRREISCLGKQTKDLEAETRNLKQDNNSLKVLVDVQEEVLVARHKKDIQNIRNSANRELLTLKNKKDMEIEKVRTIARMEGEVLRKEVHTLKSTNHTFDAKIASAKHIDHGSSIADTKTASPFQPGQDISLQYRTDNTLKCGDENQSESKAMNFGTEKEVHDCMAHLSQADIYKAHERVCKQISELQGQLELQHLHKAKLVEKSQETVRDMNIAVAQLHSSRTESAQRQETIRNQNKRDTERIEELQKAIEAYQEVNLLGVGRDYYQQRFEQSLSNLDGRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSF4</accession>
    <name>A0A194XSF4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_754782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077483.1">
        <property type="nucleotide sequence ID" value="XM_018221335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSF4"/>
    <dbReference type="FunCoup" id="A0A194XSF4">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSF4"/>
    <dbReference type="GeneID" id="28831061"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754782"/>
    <dbReference type="InParanoid" id="A0A194XSF4"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="31641" checksum="244972CC9F8596DA" modified="2016-10-05" version="1">MHALLYHSSYRRCLARIACSRCHGSHLSFKRQFSRSAFLNGHSAHNPEPIAPSLKGKSCIITGASRGIGAEIARRFAKEGVECILVGRNEKSLYGIKDELIVGDEMEHRVVVGDVGDMDFWKGMKKEVYQKKVHILVNAAGVTHYSPLFITSPSLLEEVLRTNLMGTMMACRTVGKNMMASRGGCIINVASLLGMKGGKGSAAYAASKAGVIGLTRALAAELGEKNVRVNVIVPGYVETDMTEGMSSDARSEAINAIPLKRFGQPSEIAHAAVFLAANTYANNCVLNLDGGLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT72</accession>
    <name>A0A194XT72_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_680108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077701.1">
        <property type="nucleotide sequence ID" value="XM_018214013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT72"/>
    <dbReference type="FunCoup" id="A0A194XT72">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XT72"/>
    <dbReference type="GeneID" id="28823739"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680108"/>
    <dbReference type="InParanoid" id="A0A194XT72"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="363" mass="39686" checksum="5034FF74CB3C2222" modified="2016-10-05" version="1">MMRAARFYNKLDIRIDEIPIPVPKENEVLVAVEWCGLCGSDLHEYTDGPYVIPRPGNPHVITKETLPITMGHEFCGRISQPPSNPNSKLKKGDAVMIDPRFYCSDCHRCSNGNDNACVKWGFLGLSGGGGGLSEFIAVPESVCHVLPEGVDLSVAALIEPLAVAYHAVRKTGIEDFGGKDVLVLGGGSIGMAVVVVLRMKGVKKVVVSEPTMKRQGYCRELVDVVLDPVKEKVGDRCRELTEGKGVDVVFDCAGIERAMADGMDALKFGGLYLNVAGWITPFVVPQGIFMTKEMEIRASMAYTGEDFRDTVKAFSAGKFVGIEKFVTSRVLLEDVVEKGLKELINNKDDHVKILFTPKKEYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTD3</accession>
    <name>A0A194XTD3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_178610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077664.1">
        <property type="nucleotide sequence ID" value="XM_018205597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTD3"/>
    <dbReference type="GeneID" id="28815323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_178610"/>
    <dbReference type="InParanoid" id="A0A194XTD3"/>
    <dbReference type="OrthoDB" id="3540443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="33286" checksum="3D94C7331FC65E73" modified="2016-10-05" version="1">MSTSASTASTKVELKGQLEIAKNEYQQACDTKAANYDRCQQEMTRRMTPLVAARNQALPQLVGNQNDTSRQVWQASVRDIAAEYERCQHETARLALVEVEACAKAARKVLDLEEQIDKKNQELKNWHAWSDEELITRFESGDIDYSHFMTKSGEHARNVDKLVSAYKTTQRDLFAPTRDVVRRVAYEVNFQVCKTPLNSIHWPRYRAEAGSNSDVTLAEETAPAKFDPQTIPGTSVGPGMFMSRKLVSDKDIESDMRTRLSDPKEFNVASWLQPTPELAIEATIMRPYGASRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTN5</accession>
    <name>A0A194XTN5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heparinase II N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_571749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078035.1">
        <property type="nucleotide sequence ID" value="XM_018208608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTN5"/>
    <dbReference type="STRING" id="149040.A0A194XTN5"/>
    <dbReference type="GeneID" id="28818334"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571749"/>
    <dbReference type="InParanoid" id="A0A194XTN5"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="73434" checksum="9406F22999819A6D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUT9</accession>
    <name>A0A194XUT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_8048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078328.1">
        <property type="nucleotide sequence ID" value="XM_018223422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUT9"/>
    <dbReference type="GeneID" id="28833148"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_8048"/>
    <dbReference type="InParanoid" id="A0A194XUT9"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="26491" checksum="CE4D777C3F7F6D3E" modified="2016-10-05" version="1">MTCEACQTIPPVVVTNYQTKGHYKQIAGLKTYITGPPTSKKALITIYDIFGFASQTLQGADLLAAAVGALVFVPDFLEGHVAREEWFASKEPSPEKAAFFAMLDPAGNAGKLGRFVEAAKGEVEFGDVQSWGAFGLCWGGKIAVLASGPGTPFKVSGQTHPGQLNVEDAKKLEIPHIVLASNGEDEKVVAEYKAVLVGEGKPGVVESYMNMHHGWMGTRAKLDEAENLKEYERGYNQVAAFFAKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVM0</accession>
    <name>A0A194XVM0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_679388</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078541.1">
        <property type="nucleotide sequence ID" value="XM_018213860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVM0"/>
    <dbReference type="FunCoup" id="A0A194XVM0">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XVM0"/>
    <dbReference type="GeneID" id="28823586"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679388"/>
    <dbReference type="InParanoid" id="A0A194XVM0"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="160"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ24186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23913" checksum="D4C52E310E03D120" modified="2016-10-05" version="1">MTLYYSLVFLLLVAEMTLFMLLIIPLPFTIRRKMFTFISESPLVAKLQYGMKITFIFILILFIDSVNRVYRVQLELAESNKQQGAAVLGHERMEVQARKFYSQRNMYLCGFTLFLSLILNRTYTMILDVLRLEEKVKKYEGDPKATGKESEKLANAGNAGEIGKLRKELAQKDRDLETLKKQSEGLSREYNSLGDKFTAADGTPKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWD9</accession>
    <name>A0A194XWD9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_605365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078970.1">
        <property type="nucleotide sequence ID" value="XM_018210390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWD9"/>
    <dbReference type="GeneID" id="28820116"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_605365"/>
    <dbReference type="InParanoid" id="A0A194XWD9"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="875" mass="98087" checksum="AD6F2EC1E50CBAD8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWK8</accession>
    <name>A0A194XWK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_727703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079040.1">
        <property type="nucleotide sequence ID" value="XM_018219186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWK8"/>
    <dbReference type="GeneID" id="28828912"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727703"/>
    <dbReference type="InParanoid" id="A0A194XWK8"/>
    <dbReference type="OrthoDB" id="3562645at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="255" mass="28837" checksum="C8B4C52B46AC6328" modified="2016-10-05" version="1">MAQNSLTLPATLVYEGREYSRSGIKPFILTIELVEVVPFDEDDTSEDLPEPAGYGPQQVVFGGVLYFLESTPPHEIEDSVLRTVEKDVALQQAQVLQPQPQPLQAAPPPRLANQHFPANRGFSTGPTNRAMPARARVTTAKKLPYLFDIPASQQAGIQVITPSQSNPVVRIVNGKRMRARWTNEHTQYLDELIWLGMLLTNRRLEVRDFQAVTEALHRRFRGTPDYTIRGWNTVHSYATRRPTYPKFVNHVLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWV3</accession>
    <name>A0A194XWV3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_15691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078587.1">
        <property type="nucleotide sequence ID" value="XM_018205458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWV3"/>
    <dbReference type="GeneID" id="28815184"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_15691"/>
    <dbReference type="InParanoid" id="A0A194XWV3"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="56"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="38406" checksum="1E94E6F63E579001" modified="2016-10-05" version="1">MVQNKALIFKKIPEGLPVPGKDLVVETREFDLEQAPPSGGVTTKNFYASLDPYQRGRLRSPEIKSYSPPYTLGQPLNNNVVAKIIKSDNPKFKAGDLVSGSISFEEYSAVSKEMVDATFKKIDNPYNLDLMTFTGALGMPGMTAYSSFYEIGKPQKGETMFVSAASGAVGQLVGQLGKHAGLKVIGSVGSDEKLDFIIKELNFDGGFNYKKEKPIDALKRLAPEGIDIYYENVGGEQLEAAIDCMNNFGRIIACGMVSEYNKAPNEKYGIKNLMLVVGKRLKMQGFIQGDENMAPKYREERDKNVAKWLHEGTFKAKVSVTDGIDNAAEGLVGMLQGKNFGKAVLKIADPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXG5</accession>
    <name>A0A194XXG5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_605148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078847.1">
        <property type="nucleotide sequence ID" value="XM_018210383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXG5"/>
    <dbReference type="STRING" id="149040.A0A194XXG5"/>
    <dbReference type="GeneID" id="28820109"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_605148"/>
    <dbReference type="InParanoid" id="A0A194XXG5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23913" checksum="751D6CF77E2FD8DE" modified="2016-10-05" version="1">MTYSPAQHLLEYEERVFQLGFYPDNTLYQGQPSPELDERWLELYRMGISRVPKETAKNFANKTVLFPHDEEKNYVIELDVFHQLHCLNMIRQALHPDYYTPHMPGADGEDELLGFHHIDHCVDTIRQSLMCSVDVSVLTWEWNEKRQQNLEKGAIVHTCRNFDKVRDWAREHAIDQWFDLWHHEVNDPLDESTWVDGYNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXW2</accession>
    <name>A0A194XXW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_776739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079027.1">
        <property type="nucleotide sequence ID" value="XM_018222072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXW2"/>
    <dbReference type="STRING" id="149040.A0A194XXW2"/>
    <dbReference type="GeneID" id="28831798"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776739"/>
    <dbReference type="InParanoid" id="A0A194XXW2"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="497" mass="53155" checksum="12C3CBE6C3476A6B" modified="2016-10-05" version="1">MVGKKKRGHPDIEELLARPWCYYCERDFDDLKILISHQKAKHFKCERCGRRLNTAGGLSVHMNQVHKETLTSVDNSLPNRQGLEVEIFGMEGIPEDVAQAHNQRIIAGFYQAEAERRAATGNPGPGAQAGGQPKKPKFESPADLKKRLAEHKARKAEQAAGGSSGGNTPGAQNSPLGQSPGSFNASPFPPPQSGYTAPQAAGSYGSFSQEQYTQPTPAYQQSYQQAPFSGPPGSSFPPQYSPAQSFQAGQSFPPGNGFQQGFQQGQFGAGSPPGSFNGYQGQPSQTPPHGGGLPSRPPSLPAAPGLPQRPSFGAPAVAPYQMQQMHQGPPQSGWQGNGWKGQDQNSAMSSAYPPHSQGYGDYSTNASSVDDLVSGAAREADDIDEIIRMAEAGIKPPKKGERVSTPVQALETTATPTPAPDIKPEAVEKTEVPDKPEQNEKKSKKEKQTKMFYSDNELSPEERMAKMPRYAFVPEGNTETALVNATTLPGVAGKVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B316</accession>
    <name>A0A132B316_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_692155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061150.1">
        <property type="nucleotide sequence ID" value="XM_018216476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B316"/>
    <dbReference type="GeneID" id="28826202"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692155"/>
    <dbReference type="InParanoid" id="A0A132B316"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="52139" checksum="35F863662D4F681D" modified="2016-05-11" version="1">MSDTQETNREEAADQVASKAPKSSKEKGKQPEVMDTMFVGWVPGSQNEPRKTAPRLHHKKSRTGCQQCRARRVKCNEVHPVCGSCARHQTTCVWGRPGQSPGRSNSPGSSNTSSKPKPYTIRPKLSPNLTSTSSDWDEPPESRFRRITELHLMHHYMAITSKTMTMPGDRAAPEWTVSIPKVALKHNSLLYSIYTFTAMHIAKLDPGNLENIAAYQRYMGLTLREHRDEVGVLSRANADAACLTSNFLRAINFALLQDRPMEPYTPPTEWLQMSSSTGRGLNVEAWKFIADDGNSIMRSMISNAPGLKTGGWLRDDTVLFRESNRQDLLHLLRRTDSDLVEEPWNDEIQKAYETTTSYIGSVQLSIAAKENTSNIFRRLIIFPTVVYTEFIDLVKEQRPRALVILAHFFAFLWDFRDFWWIGDCGRREVRAIENALNEEWRELMVWPLQAVDDVYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B354</accession>
    <name>A0A132B354_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_692181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061181.1">
        <property type="nucleotide sequence ID" value="XM_018216482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B354"/>
    <dbReference type="GeneID" id="28826208"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692181"/>
    <dbReference type="InParanoid" id="A0A132B354"/>
    <dbReference type="OrthoDB" id="10427443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25930" checksum="8233160811ABFA33" modified="2016-05-11" version="1">MLSRLKHPFTDTELMLRLEEKFQCKVDNIPLGSLVRNTKSPVKTRICRPNSKMGRVGFGQVGLGRVGMNDLPSSYAAGLSELSDMTEVDRKHGSLFQPKYVYTSRITASSCYIRTCKINRHRLESILQMDEPRVAKERLDAFLEERDLYLVIDYKSAVDPEVKITRKKDIKAANARTSVLVDTFLHGASRGETNSWSKCYDHGTSGPWARQAGNLDLWWALGHVVDHGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3G4</accession>
    <name>A0A132B3G4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_678374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061148.1">
        <property type="nucleotide sequence ID" value="XM_018213739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3G4"/>
    <dbReference type="STRING" id="149040.A0A132B3G4"/>
    <dbReference type="GeneID" id="28823465"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678374"/>
    <dbReference type="InParanoid" id="A0A132B3G4"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="27848" checksum="F41A1529C45BC232" modified="2016-05-11" version="1">MADVKSKKYKETVIELDVAGPKVEDVEAGRSKALALATLHEEPNSRNTTPFYVAQHPTLQSPTSPLSRANWYEVYREPGKDPKPPDPSDVSILGFYPLDISSYIRNGRFTSFPELFESHYVHAVIPSGGVALGPLESLPVEPSRRNAELFHFFIQRLSPFMCSIDGHDPPATFMDQWLPFMTQSPISIYITLLTASYFQAATHRIKVENSVDAMAAKGRLISLINAHIVTHSKGVNDESIAAVMSLAYNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3H8</accession>
    <name>A0A132B3H8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S1/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_692244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061246.1">
        <property type="nucleotide sequence ID" value="XM_018216494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3H8"/>
    <dbReference type="STRING" id="149040.A0A132B3H8"/>
    <dbReference type="GeneID" id="28826220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692244"/>
    <dbReference type="InParanoid" id="A0A132B3H8"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.575.10:FF:000004">
        <property type="entry name" value="Nuclease S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287809" evidence="8">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="290" mass="31342" checksum="B584AC17174F8FCB" modified="2016-05-11" version="1">MKFESTAPIVALAALPFASAWGNLGHETVAYIATNFVSSTTKTYFQNILGDTTTDYLANVATWADTYRYTTAGEYSEPYHFIDANDNPPTSCGVDYDRDCDSAGCVVSAINNYTTRVQETSLKSSERIIAAKMIIHFVGDIHQPLHDENLDVGGNDIDVTYAGTSTNLHHIWDTNMPEQLVGGYTLADAKTWAANLTTGIKTGTYKSSASSWLTGMDLSDPVSSSMIWAQDSNAYVCTTVMPNGVSSVENVDLSGDYYDTAIPVIEEQIAKAGYRLAAWLNLIATGSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Q9</accession>
    <name>A0A132B3Q9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_373828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_373828"/>
    <dbReference type="InParanoid" id="A0A132B3Q9"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287826" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15521" checksum="119C6F66E4C80F73" modified="2016-05-11" version="1">MFVLSQLSLCFWGLNIPVVPYTCCRTCLSLSPFNVSTCRSHLSSDNHIRTCGWISVSFLHHHHHHPREPSSKFCQNATPLSFLHLRCKQSMHACSRTHVDGFLQPGNAGCISKHACILLIIHPKSTCTFFLANNNKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3V9</accession>
    <name>A0A132B3V9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ06357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060712.1">
        <property type="nucleotide sequence ID" value="XM_018221003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3V9"/>
    <dbReference type="GeneID" id="28830729"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743968"/>
    <dbReference type="InParanoid" id="A0A132B3V9"/>
    <dbReference type="OrthoDB" id="5380548at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24002" checksum="17373544338C2A70" modified="2016-05-11" version="1">MATVAFKSYTYVPTAPRFKSAISRRKPASKPISIFDKLQRMKPSSAGLSTPPSATAADDCGNGGLGIRDEYELEVLGSTLDIDPVDKRKRQQEELEQKKDEAQSEDNGLQRDVNDLAAVVTTERVDDTHSSDKGGSPRLAKRQKLLPSYDPLPKLSHNKAKGRNDGNSDDELNNNKTSLEENSKELRSMKRKQLFSLHDSPMQKKPPSTLSQASHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4K6</accession>
    <name>A0A132B4K6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_767255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221751.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28831477"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_767255"/>
    <dbReference type="InParanoid" id="A0A132B4K6"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF30">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287840" evidence="3">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="118"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="421"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="57459" checksum="DE73405E731AF869" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4S0</accession>
    <name>A0A132B4S0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_726342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061022.1">
        <property type="nucleotide sequence ID" value="XM_018219049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4S0"/>
    <dbReference type="GeneID" id="28828775"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726342"/>
    <dbReference type="InParanoid" id="A0A132B4S0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24634" checksum="5E257CE82719DB70" modified="2016-05-11" version="1">MPFSFNEAQTAILDRYWDQRRYLFKNGRLPKRTSMSVAVQCAEVGPFVSSQIIGRHFANRVAAEEGRPRAHRKTPRQFELLGNSFEDDPFPSTGELILLVHESGLKPQQVKSWFDGQRQKASKKGELLTTRNRENDPDSNDSAKMWRAFKKDPGSYCKALCRGEISPVTGKAQEVELDEEEGDEESEVDEEGEAKGGDDTNQQSEELMYGPEESREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5N8</accession>
    <name>A0A132B5N8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_601214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061918.1">
        <property type="nucleotide sequence ID" value="XM_018210189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5N8"/>
    <dbReference type="GeneID" id="28819915"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601214"/>
    <dbReference type="InParanoid" id="A0A132B5N8"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="32755" checksum="C0F4922A4B4CA5E2" modified="2016-05-11" version="1">MPKPDLLHFDDLPEWYQDNPAVRSAYRPVSYSSVPCLHSLTYLHNETLNIYTHLIPAILSIFAQMYIQALITHHFPRASSRDRLIFGANILPGMVTMILSTCYHTLMNHSFPVSSLFLRIDYVGILTLILGSFFSGIFVGFYCEPALQRVYWTMIIALSVVTSVLVLHPQLQGLRWRSHRTAAFVATALSGFAPIGHGLWLYGWSEMWVRSGMPYWFLEGIVYGLGAFFFATRFPESVWPGKFDIWFCSHQIFHVLVVCASVVLLKGVWDAYAWNYHNNQQCLATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B609</accession>
    <name>A0A132B609_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_691872</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061784.1">
        <property type="nucleotide sequence ID" value="XM_018216424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B609"/>
    <dbReference type="FunCoup" id="A0A132B609">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B609"/>
    <dbReference type="GeneID" id="28826150"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691872"/>
    <dbReference type="InParanoid" id="A0A132B609"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="103"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ07429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="55087" checksum="E6A3A78D36712DBB" modified="2016-05-11" version="1">MPLTGEEIAKHNSRESCWVIVHGKAYDVTEFLPEHPGGPKIILKYAGKDATEEYEPIHPPDTLDKYLDKSKHLGVVDMKTVEKEEKEESPEEIERQQRIERMPILEQCYNLMDFEAVARGVMKKTAWAYYSSGADDEITMRENHTAFHKIWFRPRILVDVEKVDFTTTMLGTKVDIPFYVTATALGKLGNPEGEVVLTRAAKKHNVVQMIPTLASCSFDEIMDAAEGDQVQWMQLYVNKDREITKKIVQHAEKRGCKGLFITVDAPQLGRREKDMRSKFTDTGSNVQAGSTTDNSQGAARAISTFIDPGLSWKDIPWFQSITKMPIILKGVQRVEDVIRAIESGVQGVVLSNHGGRQLDFARSGIEVLAEVMPVLRERGWENRIEIFVDGGVRRATDIIKALCLGAKGVGIGRPFLYAMSAYGQPGVDRAMQLLKDEMEMNMRLIGCSNVDQLNPTLVDTRGLNMHTTSVPSDTLGMSVYDPLVSPKEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B787</accession>
    <name>A0A132B787_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062099.1">
        <property type="nucleotide sequence ID" value="XM_018216334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B787"/>
    <dbReference type="GeneID" id="28826060"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691475"/>
    <dbReference type="InParanoid" id="A0A132B787"/>
    <dbReference type="OrthoDB" id="5429909at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="288" mass="31975" checksum="ABDFF9BCAE9373ED" modified="2016-05-11" version="1">MHGDPEFFFLKPVAWMDAKKWENKMLGAFLKEYPSPTNGYVAESGPENKSLFEQYDSFGTEDGQFNDFVLDAHASAKKGVSATLKSLANVSFDGETTHAHSLEGKYLRFRRLTQLDVFFDKAKKDVEVSKRVPNWIKSGLKIPVCVVVGIMICEDVEVVWEEGAKKAVEAKGEIPIATIARAAAGIPPIPGAADDTGNLGAQYTNQREEGKVFRAKTGEMKIFALQLRNVTRGRMLKLFQRNELHMGDDSTSADQGRKFGVDEKTPLDDVDDNDLFLEMDDANDSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7L1</accession>
    <name>A0A132B7L1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_725234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062706.1">
        <property type="nucleotide sequence ID" value="XM_018218964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7L1"/>
    <dbReference type="GeneID" id="28828690"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725234"/>
    <dbReference type="InParanoid" id="A0A132B7L1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="64365" checksum="71860F5DFE3A28EB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B874</accession>
    <name>A0A132B874_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_334957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062963.1">
        <property type="nucleotide sequence ID" value="XM_018206815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B874"/>
    <dbReference type="STRING" id="149040.A0A132B874"/>
    <dbReference type="GeneID" id="28816541"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_334957"/>
    <dbReference type="InParanoid" id="A0A132B874"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="33613" checksum="E4AFFFCF2067C0E0" modified="2016-05-11" version="1">MSSSKGKSPATGDEDGELNNSEDTAEPSFLSRVAASASGLTRSAFGSPGGNELNEQAAAALSNAGKGQSSTRTPGESSWAEGSKLVQSPSQPPGRGSSGLRVGQSEAHVRQSENEFSDFLDGIDSFSPSTESANSQVGEVPNGFKQVWAHSQITPQPLHGERLAGTVAEQESQDGQGVLDLLSGPASLHEPFEAPEEDEEFYDWGLSQDQIIELRAMLKDILPPLEQHTGVAADNPLNLVPNSNEYNKAQWFEEWDGVLNRYADEVWGGLLPLVKDARKELDDIRNGEVAAEQPKALRRLNAILGHLQKRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8G2</accession>
    <name>A0A132B8G2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_711394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063016.1">
        <property type="nucleotide sequence ID" value="XM_018217900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8G2"/>
    <dbReference type="GeneID" id="28827626"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711394"/>
    <dbReference type="InParanoid" id="A0A132B8G2"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287960" evidence="5">
        <location>
            <begin position="23"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="519" mass="55664" checksum="24F9B26106A85F67" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B976</accession>
    <name>A0A132B976_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">DUF924-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_742067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062582.1">
        <property type="nucleotide sequence ID" value="XM_018220785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B976"/>
    <dbReference type="GeneID" id="28830511"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742067"/>
    <dbReference type="InParanoid" id="A0A132B976"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="232" mass="26182" checksum="6B8E0BB1247D50D1" modified="2016-05-11" version="1">MRAYNFTSAFSKILGLQTAFKSTLLSPTFFRPMSSISTMDTDINRTLSYWFDGPEAKKKWYGGGEKIDTEIRDQFGPLMEQARASELNSWESKPRGSLALLILLDQFSRNAFRSTPDSFSADSLALDIATKAIAKGFNLEVSNIQQIFFLMPFMHSETLLGQVAGVSLFEALLARCDPNSKDVEFLATSVQFARRHREPILRFGRFPSRNEILGRTSTPEEIEFLKEHPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9T0</accession>
    <name>A0A132B9T0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_676519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063513.1">
        <property type="nucleotide sequence ID" value="XM_018213595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9T0"/>
    <dbReference type="GeneID" id="28823321"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676519"/>
    <dbReference type="InParanoid" id="A0A132B9T0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="192" mass="21246" checksum="1334C8FB0E624BFA" modified="2016-05-11" version="1">MAGLDAWETFGVRKLLVLRYSSNSAQFLAISSEVSSPRKKRSNVNAAEATAGCIGAGIAIRNHAPRDEVIRGSGVRVQSTTFNRWTLKCIEAGDSQGRSVLCNRELPAKRLSDFGSMHVVVAVVERLLPPICCVSSRRRCVCPRQQEVRVAVRKMKKSSIDREEEGADKGTKRWTLVKRDSAFTSAAFYDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9X5</accession>
    <name>A0A132B9X5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_690265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063560.1">
        <property type="nucleotide sequence ID" value="XM_018216061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9X5"/>
    <dbReference type="STRING" id="149040.A0A132B9X5"/>
    <dbReference type="GeneID" id="28825787"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690265"/>
    <dbReference type="InParanoid" id="A0A132B9X5"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288035" evidence="2">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="4">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="433" mass="44370" checksum="AF89FD665A14E44D" modified="2016-05-11" version="1">MKYTLATLALGGLASAAGIPRDTCSCKFTITASGGQSGVVGQLSDGQNRIGGGNPTGEYCINNGQITDSQGRGCILTPPTTQFQCDTGATPTSGFSLGSNGQVEYNGSQTFYACPASDTMYNIYTTPVSGQTKCVEVQLTASGCYAQSSSAQSMPATTMKTSMQMTQPHTTTVVKTVQSSCPAPQTATVTQVKTAEASCPAPQTSTVTQTVVKTAQATCPAPSTVTVTQPAATQPASSKPASSKPASSQPASQPASSMASSTAPATTPSSTGKTCPTNLSGAYQYPHLIIPVSKSQPNKACGTSYDGTITSDISSIFNFDIPASYTGTCSLVFLFPTQAELQTSSYTFSGNGEFDFAQLNTVATQSTDYANMGSVKTDFGTKTATPGSSVVVSTFACPAGQAVSYEISSVSGSSLTYFQDYNPSPIGLYITSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Z3</accession>
    <name>A0A132B9Z3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_598214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063581.1">
        <property type="nucleotide sequence ID" value="XM_018210027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Z3"/>
    <dbReference type="STRING" id="149040.A0A132B9Z3"/>
    <dbReference type="GeneID" id="28819753"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598214"/>
    <dbReference type="InParanoid" id="A0A132B9Z3"/>
    <dbReference type="OrthoDB" id="3466524at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="112" mass="11934" checksum="5F0232430A03FBD1" modified="2016-05-11" version="1">MPPPLCIPVPGQDWGNADAGLIQDGINYLSGLQGGCCVGPTSCVRISCSWNSAIFLCNDNGYTICPNCGYLATYASDMINDCSSWNGGDSIIVGGQLFDSDHYNIIVRWDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAA4</accession>
    <name>A0A132BAA4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_690792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063149.1">
        <property type="nucleotide sequence ID" value="XM_018216173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAA4"/>
    <dbReference type="GeneID" id="28825899"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690792"/>
    <dbReference type="InParanoid" id="A0A132BAA4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="440" mass="48123" checksum="507ECE758D8E710E" modified="2016-05-11" version="1">MSNITSEYPHGGLAIVGGGIAGVTLALGLVARGIPCKIYEQGHSFAEIGAGVAFAPNSIRAMRACDANVYTAFKAVATHNTWESKRADRELGRKGLYFDFLEGFHENDKLLFSLYNDEGANSVHRAHFLDEMVKFLPKDIAAFRKRVERVEESAGQGPVTLHFADGTSTTADAVVGADGVKSHVRQSLLGAEKPESHAGYTYKYAYRGLIPMDKAVAELGEEAAVNSRMYLGPDRHVLTFPIDKGETMNVVAFTTTSQNWPDIHKSTRAATKQDALNDFSGWGPTVTHILSLLNEDVDIWAIFDMKDHPAPTYAKGKVAIIGDAAHATSPHHGSGAGFAIEDSAVLAELLADPAAKRPSGLRVAFQAYDQCRRQRSQWLVASSRRTGELYEWQAQGVGYDIEKIGAEVHERFEKIWQGDIKQMIANAQAAFQRLLPYSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAK1</accession>
    <name>A0A132BAK1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_724864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063239.1">
        <property type="nucleotide sequence ID" value="XM_018218937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAK1"/>
    <dbReference type="FunCoup" id="A0A132BAK1">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BAK1"/>
    <dbReference type="GeneID" id="28828663"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724864"/>
    <dbReference type="InParanoid" id="A0A132BAK1"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="175"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="529"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="815" mass="91614" checksum="B3F661A78B25AA0F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBB2</accession>
    <name>A0A132BBB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_657175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064067.1">
        <property type="nucleotide sequence ID" value="XM_018212419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBB2"/>
    <dbReference type="GeneID" id="28822145"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657175"/>
    <dbReference type="InParanoid" id="A0A132BBB2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="36087" checksum="5C710D5654B6115C" modified="2016-05-11" version="1">MTTSNFPLLSFQEFLTGSEVEKRAVAQKLYNAFHTYGWVYLQDFGITKEEIAEMFAMSKKYFDRPLYEKLKQTLNDAETNQGYTPDGAEANGGTDHKECYEHRRLSNELCPTDQELTNFRVFMDDFYAKCFKLSVNVLQALALVMDLDMDYFSSALAKADPQLRLLHYMPIERKIIESAGHARIIPHTDFGLCTLLFQDNVGGLEVDPFHTGKFLPATPIEGTCVINVADLLQRLSNDRLRSTLHRVTSPPLEKVGNDGMLPARYSTAFFVHPSADVEIDPILRDGEAKKYESVNAGKWRTMNTQKNYSNLLGGSALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBL8</accession>
    <name>A0A132BBL8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_286214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063754.1">
        <property type="nucleotide sequence ID" value="XM_018206488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBL8"/>
    <dbReference type="GeneID" id="28816214"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_286214"/>
    <dbReference type="InParanoid" id="A0A132BBL8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30010" checksum="1DE3273116B8033D" modified="2016-05-11" version="1">MDQDRGKTYPFINNLLDHDLGLVDLGPSALEGDVDELTSTRSGSILRFGWHLDVNHMSGILDLVDLRTLRADNLAGSSREHLHDLLHLYASINNTVSTTSTNTLGKICTTRDFGLNLNMDFGTVLVEILSHTLANVLDDVDPAWSPVVCVDLINSQGVLVLLRIRSPSGVGRDNMIRCIITLKVSGNQLDDGDTVLETVGDTNRKVGADFEGITHVSLTVVDFDVLSLLTGNWRDGSVEVPSKASVDVVQDLASVLVRLCLCMSALVPIEPKSRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD37</accession>
    <name>A0A132BD37_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_256627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064636.1">
        <property type="nucleotide sequence ID" value="XM_018206238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD37"/>
    <dbReference type="GeneID" id="28815964"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_256627"/>
    <dbReference type="InParanoid" id="A0A132BD37"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="47362" checksum="08C55B83F89F501C" modified="2016-05-11" version="1">MTIHTEMTDFHWPTCEPDFGFQNALEGLQDTICPSLYSDTWAPPFMLEADALVRSPSSLSEDYLFLKHTLLELQAESPPGSRAQHDDDDTSTQRSRSDTSISLNDWASPAHPAVQPLDHKLQCTYHDCTAKPFKTLCDFKSHMRGHAADVLEQWEEEKPCRCPWSGNCKSKAVFKSRRILQTHLENVHITPLTCTASGCSYRKPFRSNYDLKRHMLTAHSGDSNCQFLRCPYPKCDRGPRTFVRKDKWLIHIRTSHDGTECPINHCKAGKRDGLLTHDDLVKHIRHEHGKFECAIGACDSQLPSRFIESELLKHLEVSKSVLDFCPLVMSHFGPRQCNILTTCFSKLHHGLPYGAINTARSAVKISSDKTVKPTDVSSCWQECEQCKEGNFEEKSEIETKPGTPDEFRNHTLSFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDH6</accession>
    <name>A0A132BDH6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_627020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064837.1">
        <property type="nucleotide sequence ID" value="XM_018211129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDH6"/>
    <dbReference type="GeneID" id="28820855"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_627020"/>
    <dbReference type="InParanoid" id="A0A132BDH6"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="287" mass="32617" checksum="44017C5307982A42" modified="2016-05-11" version="1">MVTSIDPSVTVDTPKIEIGSRDKSVGWYMPTLDSITDTQRDLLENYSKIAPERVISHLFEIRDKGWEIWPHPCIGQFRFIDLSIMRTPSYQNILSRLKSGSSILDLGCCVAQDLRKLVHDGAPSTNMYGADLHGDFLSLGYELFLDKETLGAKFIQADVFDLDGPLKYLEGKMDIIQIGLFLHIFDLEGQIRACERIVRLGRPVKGTLIVGQQTGKQVAGNQPTRRGKAFKHNVETFENMWKVVGEKTGTHWEVRVKMDEGLGFADKKRTWDDPSIRRLAFEVERMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDM7</accession>
    <name>A0A132BDM7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beach-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_277073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1838"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2010"/>
            <end position="2304"/>
        </location>
    </feature>
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        <location>
            <begin position="2437"/>
            <end position="2478"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
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            <end position="1801"/>
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        <location>
            <begin position="2593"/>
            <end position="2619"/>
        </location>
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            <begin position="1766"/>
            <end position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2653" mass="297631" checksum="971382188019A785" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDN4</accession>
    <name>A0A132BDN4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_627110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDN4"/>
    <dbReference type="GeneID" id="28820861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_627110"/>
    <dbReference type="InParanoid" id="A0A132BDN4"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="214"/>
        </location>
    </feature>
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        </location>
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            <end position="364"/>
        </location>
    </feature>
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            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="490" mass="54322" checksum="EBBA841681BBCE6A" modified="2016-05-11" version="1" fragment="single">MRLKSDDLGIWESVGRHKYITFVGMAAAFSASLDGYQISLNGGIVSNKGFIRQFASPGTKIILGKYVSAWGGIQSAGQTIGQIFLQYATNSLGRKPALLILWCFLAASIFAESFATKWDHWLVAKLFSGAGVGMLQATMPVYLSEMAPTQLRGYLINAYSFWFVIGQLLGSVALNRLNASDPYDFRAAIYTQWGMVGVMLVIFLLLPESPWWLAGKGKLDKAKKILLRFNGHIEGYNVQENIDVMTATIDMERYTAELNKEEGQWAIFEGRNLIRFIIASWPKVTQQFVGLSVFNTYATYFFQAAGNKNPFLVTVILCCVQILSMIVTSTLTDRFGRRPLTVYPYGVTVLSLLALGIVGCFDYTKRDTSSLLVFFACLATFSTTGASAIGYAYAAEIPTQRLRAQTAGWALAFSNLIAIMFSFCTPLMINGTAKWGVKTGFFFAGTGAVSVVIAWFLLPEVARRTPAEIDEMFEKRVNLRKFKSYITDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEM0</accession>
    <name>A0A132BEM0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_270563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064482.1">
        <property type="nucleotide sequence ID" value="XM_018206362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEM0"/>
    <dbReference type="GeneID" id="28816088"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_270563"/>
    <dbReference type="InParanoid" id="A0A132BEM0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="53346" checksum="46B2D837A34404B2" modified="2016-05-11" version="1">MDLLASLLDQSVGCWIVTILVALAGTFVVQTCRSWYRLRHFKGPWLASISRLWLVRSISGGRFHLDFMEVNQKYGSLARIGPNDLVTSDPAVMRRMLAVRSHYRRSDWYIGMRFDPTRDNIESIMDDDRHTKLRSMMAAGYSGKENEDLEGTIDRNIQNLIKLIRAKYLSTDSESKPLDFGRKAQYFTLDVISDVAYREPFGFLAADRDLYDYIKEAEKVLPAALMVTIFPVLNWVLQLSILKAALPSDKDPLGMGKIIGITKKVVAERFGKNKKVQQDMLGSFIAHGLNQEDAESETLLQIMAGSDTTASGVRAILLYILMNPRVLAKLRVEIASTPISSPIQEAEAKKMPYLQAIIKEGLRIFPPLVGLMSKAVPPEGDVINGQFVPGGTKIGYGAYGIFQDKKTWGLDADVFRPERWIEETADKLKDMESTLELIFSYGKYQCLGKNIAMMELNKIFVEVSYSSMSAKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT53</accession>
    <name>A0A194WT53_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_674960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065204.1">
        <property type="nucleotide sequence ID" value="XM_018213475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT53"/>
    <dbReference type="GeneID" id="28823201"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674960"/>
    <dbReference type="InParanoid" id="A0A194WT53"/>
    <dbReference type="OrthoDB" id="3556826at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267480" evidence="2">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="35864" checksum="CC5D0653B4C88B39" modified="2016-10-05" version="1">MRILQCAHVLLSVLSFLALSDCRIVGRTNNRVGARQEFHNELVRLEELARTRLPWNLNDADHLERLKLRTANGLKVRDDDEPPFELTGDQTSMVLNLWENTRFKVPVNNMFVKYDITTDNSIVMTTYSCYGCTAVVMCSAPGKLCIFAHFRQENGGKKDTWPKGQSQDVAFAIHVLEPINEAIKLYKDPLVLGGPLCIIFSPGISVPPRSFIYPWRIKGEGSINEAITDAFPSASILNIGYNYPTSKGDWGDDWGWGKLVLEWVGGASSCANGGSSLLNVFAEENWWRSLRFDDDGNPVTVDKTPCQSPVGSQDGFDGDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTC2</accession>
    <name>A0A194WTC2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065279.1">
        <property type="nucleotide sequence ID" value="XM_018215915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTC2"/>
    <dbReference type="GeneID" id="28825641"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689476"/>
    <dbReference type="InParanoid" id="A0A194WTC2"/>
    <dbReference type="OrthoDB" id="3552855at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="236" mass="26734" checksum="F01291B906198D27" modified="2016-10-05" version="1">MPKYTVFLIVADRSANRSEEEKKKQSDDVKKDPSFNKFMKEFLDWIGEETNAKRLKSADVLEESTEQTSIRVNFHSDETPAAEAEKDDDTKFMPPTKSLTTRGHLECVSANILGYYTAEFPTINDAATWAQSCPIAFDGFALEIRQLTDTDKTISEATPEVKEWAGDQIVSARKQLVEEGKLKKEEDETLWVKVEDSEEIKEVVTEAEKRLAEKGDDEKGEAEKVDAVAEKEKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTK3</accession>
    <name>A0A194WTK3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_595595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065302.1">
        <property type="nucleotide sequence ID" value="XM_018209870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTK3"/>
    <dbReference type="STRING" id="149040.A0A194WTK3"/>
    <dbReference type="GeneID" id="28819596"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595595"/>
    <dbReference type="InParanoid" id="A0A194WTK3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="49795" checksum="113E6B7DF4FF03F3" modified="2016-10-05" version="1" fragment="single">DRTVFSITVMGAEIYVVTSPDDVLTVYKNTNTTVFDYNAQIKDILGIFGFTSRTMNLLFDEEKFGGKSWMDLCHEKFKLQMHPGEKLDELQANLLSNLDHSLTFNLLSGDMIQPGSTEKEKVVSLYAWCSEVLVDAATKAFYGKALYEVAPNLLPEFLIFDDEAWKLYSKYPEFAAKKMFRYKAKVQSAFERYVDLPKEQRQDASWLIKNIEESLVELDVTETSQLAPNLFLLHRLLNTNAYKQCFWCLAYLLHDQQLLQAVKAEIQPAFQADGQLNLDYLLDNGPLINSLYEENLRLCNAPIGARQVMSKFALGGKVLKTGNMLLMPYRQLHFNEQVFGTNATEFDAKRFLKDKNLLRSTSYRPFGGGSTYCPGRFLAKREVLMFVALVLFRFDISLVGKDGEKAKFPRMDVTIPLGGVMGPVVGDDIIMEVRPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTU4</accession>
    <name>A0A194WTU4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_674703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065738.1">
        <property type="nucleotide sequence ID" value="XM_018213456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTU4"/>
    <dbReference type="GeneID" id="28823182"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674703"/>
    <dbReference type="InParanoid" id="A0A194WTU4"/>
    <dbReference type="OrthoDB" id="10570458at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18939" checksum="34B9EAA412C2F5A7" modified="2016-10-05" version="1">MASVHSQPEDEPSSIGPEIHNKFVTFETTSQLYRLPLSSPLATTFLTLSGPSKIEFLKEHGEVIAKKSIEERGRIMIHHSGSFIFWNEGQIEYLVPREKEGWEDHELSKEFEKLVERGEGRREWILRNAMRIKEWPDHAQRKQSVEFVKRGTGEKENSELHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUF5</accession>
    <name>A0A194WUF5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiation-specific alpha-1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_594840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065654.1">
        <property type="nucleotide sequence ID" value="XM_018209825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUF5"/>
    <dbReference type="STRING" id="149040.A0A194WUF5"/>
    <dbReference type="GeneID" id="28819551"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594840"/>
    <dbReference type="InParanoid" id="A0A194WUF5"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38026" checksum="3BDA864F24757BC7" modified="2016-10-05" version="1">MSSTEPSQWAEKASIYLETLDLPRYTRPRLTRYLISILAFLSLIVFYTSHQPSLLISEPEFPSISIYAANNTNHLPHIPPKIWQIYLDYTPYAIMPYTSYIQSFITHSPSHTYTLLDAHGALSIISKLSTSKTHAHILPLFYAMSRRVLRADFLRYLLLAIEGGVYSDMDTEMLRPLHDWVPDEYKSRTKLIVGLEADQSPPVGGTTYEVQFCQWTLAGAAGHPALWGMVERILNEVQKRPFESPMKDVEFSDEEVLDITGPAGWTEVVYEYLSKAAGEEIGWRNLTGMRSPRLFGDILVLPIDAFASGVPHSGASGPGMGEAFVKHQFQGSWRGGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV10</accession>
    <name>A0A194WV10_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_623942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066163.1">
        <property type="nucleotide sequence ID" value="XM_018211036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV10"/>
    <dbReference type="FunCoup" id="A0A194WV10">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WV10"/>
    <dbReference type="GeneID" id="28820762"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_623942"/>
    <dbReference type="InParanoid" id="A0A194WV10"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="909"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="937" mass="106497" checksum="F382F57BDF6A9743" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVL3</accession>
    <name>A0A194WVL3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 3A17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_739059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065987.1">
        <property type="nucleotide sequence ID" value="XM_018220435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVL3"/>
    <dbReference type="STRING" id="149040.A0A194WVL3"/>
    <dbReference type="GeneID" id="28830161"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739059"/>
    <dbReference type="InParanoid" id="A0A194WVL3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="517" mass="58945" checksum="68FD8A4671D95474" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVW4</accession>
    <name>A0A194WVW4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_653813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066460.1">
        <property type="nucleotide sequence ID" value="XM_018212268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVW4"/>
    <dbReference type="FunCoup" id="A0A194WVW4">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVW4"/>
    <dbReference type="GeneID" id="28821994"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653813"/>
    <dbReference type="InParanoid" id="A0A194WVW4"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="34882" checksum="3191CE872D259BE8" modified="2016-10-05" version="1">MASRKAICALSSKAIRPRASNFLSARQQLRAESTSSSTSALAYKALHRRIYPLPTSDAPPSWSAQAAVSNILYETPTPSAAPPKRHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCHTEVEDLSRMTIVLSGQDGVVEQARRQLEDLVPVWAVLDYTTAPLVQRELLLAKINILGPEYFEELQAHHREITAGDEEGLEGSEDWAQKRSETNDFHPSKLALSQALRLKHEHLKSITYFTHQFGGKVLDISTNSCIVEVSAKPTRIDSFMKLIAPFGILESARTGLMALPRSPLYGPNEAELPKDADDIVDASALPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWJ4</accession>
    <name>A0A194WWJ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_688522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066404.1">
        <property type="nucleotide sequence ID" value="XM_018215725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWJ4"/>
    <dbReference type="GeneID" id="28825451"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688522"/>
    <dbReference type="InParanoid" id="A0A194WWJ4"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="116"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="35577" checksum="2089767C23EF6017" modified="2016-10-05" version="1">MSQYTQLPQTSSTTKILLDDEDHSHSLPSHFDLALNGNGGTTTTTSSFLSPKQATYASSLLDPDAFRRLSISTISSLARPRSVSPYPPHPHPHPSSLQGPRTWKSALHQIWQQNQGLFLVTFSQLFGALMNVTTRLLELEGEGMHPFQVLFARQGLTVLFCTAWMWWTRVPDFPLGKRGVRALLVARSVTGFFGIFGMYYSLQYLPVADAVVITFLAPSVASYGCYLFLHEPFPRSAQYASLISLLGVVMIARPTSFFTSSSSASPDVTVPANTTTSSVEESGFPTPTSGQRLSAVVVAMIGVLGSAGAFTSIRWIGTRAHPLLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWL2</accession>
    <name>A0A194WWL2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_206348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066721.1">
        <property type="nucleotide sequence ID" value="XM_018205824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWL2"/>
    <dbReference type="GeneID" id="28815550"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_206348"/>
    <dbReference type="InParanoid" id="A0A194WWL2"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="513" mass="57226" checksum="98A5AE85525F9B0A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWS5</accession>
    <name>A0A194WWS5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_206691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066750.1">
        <property type="nucleotide sequence ID" value="XM_018205826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWS5"/>
    <dbReference type="GeneID" id="28815552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_206691"/>
    <dbReference type="InParanoid" id="A0A194WWS5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="100" mass="11209" checksum="F676BA6DD1327286" modified="2016-10-05" version="1">MGNETDNIEAAPRTQIHTTLDADLKGQTADEGYELFEEAQNESTSYSVEATEAVRRKIDLHLLPLVCILYGLNYVDKVAMGWAVLFNFRDDLGLHGTQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWY4</accession>
    <name>A0A194WWY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_208565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066846.1">
        <property type="nucleotide sequence ID" value="XM_018205845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWY4"/>
    <dbReference type="GeneID" id="28815571"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_208565"/>
    <dbReference type="InParanoid" id="A0A194WWY4"/>
    <dbReference type="OrthoDB" id="3561291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="782" mass="87110" checksum="E78647AE41D1D749" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY15</accession>
    <name>A0A194WY15_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_709406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067218.1">
        <property type="nucleotide sequence ID" value="XM_018217757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY15"/>
    <dbReference type="STRING" id="149040.A0A194WY15"/>
    <dbReference type="GeneID" id="28827483"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709406"/>
    <dbReference type="InParanoid" id="A0A194WY15"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267588" description="cellulase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ12863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="34814" checksum="144CA2F9F73F3C43" modified="2016-10-05" version="1">MSFKLSLIGLVASLLASIPIVHAAEEYPLLPTWKCTSSGGCVQQNTTVVLDKDSKQAAGAAGSRTAADYAAMGVSTSGNALTMYHYVKTDGTLNAASPRVYLLGDDGKYVLMSLLNQELSVDVDLSALPCGENGAFYLSEMAADGGTGGAGGGNGYCDAQCQGYCCNEMDILEANSMATAMTPHPCKGNTCDKNGCGYNPYASGQHNYWGPGKTVDTSKVFTVVTQFAASGGKLSQLTRKYIQNGKQIGGGGTISSCGSEGSTGGLTGMGQALGRGMVLAMSIWNDPTQQMAWLDAGTDGPCASGQGSPSNIQSQHPDTHVVFSNIRWGDIGSTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY73</accession>
    <name>A0A194WY73_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_688270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066989.1">
        <property type="nucleotide sequence ID" value="XM_018215673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY73"/>
    <dbReference type="GeneID" id="28825399"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688270"/>
    <dbReference type="InParanoid" id="A0A194WY73"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267594" description="Peptidase S53 domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="212"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="645" mass="69918" checksum="2CAB05FBD0387606" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYG6</accession>
    <name>A0A194WYG6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_652373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067340.1">
        <property type="nucleotide sequence ID" value="XM_018212197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYG6"/>
    <dbReference type="GeneID" id="28821923"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_652373"/>
    <dbReference type="InParanoid" id="A0A194WYG6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="59"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="59513" checksum="33EA08E0CC32BA21" modified="2016-10-05" version="1">MDEEFDHDKKINRATDFKYPTIQAKRQVRLLRARFDEEHKNVVYSLEVVPLSELPWECYKALSYTWGHAHTADDVRAIQIDNQPFSVRRNLFQFLEAAADREEYGLFFIDAICINQLDHEERQSQVQEMARIYRNSNEVIGWLGIPEINQIDNIRPLSGTKRNAHEGCPTWSSSQWEGFRYLSQHNFWSRLWIVQEVLLAESMTIWCGSFTFPLSLFGSATKTSPILDVRIAPNGRPHKVISPTARLQSPATTIVTHRLRSVPRPLRGQDPLAQGTIIGTLEEMTTGLKNPTERMTTYQSKIADLYHEVISKFGRLECSDPRDKLYGFLGILNEKSRAKVDVDYRKDVSYAFYQALKIGIQEIFLEHGGVVYPDDRNCKSSDYLAFYCDVRDAFGIDDKETLVILGKVLEELNFRKWVQEAEFEVQNQQQFVWRDQIVDVHPGFKWLSMFAEIEKEGEDGGNGLYRYHQRQGKMIERLMAWFRDRSRRKDHFRRLEKSRQQPLIVREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ00</accession>
    <name>A0A194WZ00_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_784938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067535.1">
        <property type="nucleotide sequence ID" value="XM_018222837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ00"/>
    <dbReference type="FunCoup" id="A0A194WZ00">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WZ00"/>
    <dbReference type="GeneID" id="28832563"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784938"/>
    <dbReference type="InParanoid" id="A0A194WZ00"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="381"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ13180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="63228" checksum="A5A1D8503EB6F46F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ79</accession>
    <name>A0A194WZ79_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067611.1">
        <property type="nucleotide sequence ID" value="XM_018215499.1"/>
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    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="632" mass="71337" checksum="768BFB63E11CFD35" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X052</accession>
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        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_651823</name>
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    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067933.1">
        <property type="nucleotide sequence ID" value="XM_018212183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X052"/>
    <dbReference type="GeneID" id="28821909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651823"/>
    <dbReference type="InParanoid" id="A0A194X052"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="521" mass="57802" checksum="FEAA249DDE6E669F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0L7</accession>
    <name>A0A194X0L7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_590397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068090.1">
        <property type="nucleotide sequence ID" value="XM_018209593.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_590397"/>
    <dbReference type="InParanoid" id="A0A194X0L7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="435" mass="48497" checksum="5F6A91350FED8733" modified="2016-10-05" version="1">MDKSVMAQSFIYGLEESLNLKGHEYSWCGSAFYFGYLAFQPFAGRLLNYLPLGRFVSATALSWAIILLCTPGAKSFSGLFACRFFLGMAEGGVSPAYVLITGMWYKKDEIPQRVTFWFTGNGVAIIIQALVSYGIGHINTSVATWRWFFIIFGILGLVWAVVLYLFMPDSPLTAKFLNEEEKAVAVERLRNNRTGVANKEFKKYQLIEALKDPLVYYSFFYAISCVVPNSGVSFFGAQIIKGMGFNNFVSSILLMPFGLCETIALLTAGYVTRNIPNLRCLNQFLWCVPAVFGAALVYCLPSSNRAGRLAGFYCTGFSNAGLPLQFSLMSSNVAGHTKRSVGNAIMFFGYATGFIIGPQFFLSSEAPVYPTGFKTMIITFGTACLGPVGLWFYLGWLNRRREAALRESGNENVYARNEEFLDLTDREQIHFVYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0P7</accession>
    <name>A0A194X0P7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_591637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067792.1">
        <property type="nucleotide sequence ID" value="XM_018209662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0P7"/>
    <dbReference type="GeneID" id="28819388"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591637"/>
    <dbReference type="InParanoid" id="A0A194X0P7"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23142" checksum="F5A822636E9CD982" modified="2016-10-05" version="1">MSKKNKHLSLSKTPATLQTSSETTPTAWSHKPSNLTIAWLLISIPLVIWDTIYVLFRPLTMPGGSLQYPLYIPYEIYLQTDYIYGWKALEQNNGFTAAQATMNIVETALYCWYLYIVLDRKYVGGKAGTLAVLVGFSAALMTLSKTVLYGLNEAFSGWSNVGHNEWGHLVLYYIIPNGSWLVASALMSMAFGSEILQGLSLAGGEVLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0W1</accession>
    <name>A0A194X0W1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_754481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067959.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0W1"/>
    <dbReference type="STRING" id="149040.A0A194X0W1"/>
    <dbReference type="GeneID" id="28831053"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754481"/>
    <dbReference type="InParanoid" id="A0A194X0W1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF3">
        <property type="entry name" value="ATROCHRYSONE CARBOXYL ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="250" mass="28042" checksum="299976AD47C06F62" modified="2016-10-05" version="1">MTSTANRGGYRQINKTLNICVFENYLDIQQSRLPHLNDVEQLGPRVIRVLGQNRGKSALVRRGSLSIPAKGFRNGQRFSVEGATIRAVHSPGHSHDHMCFILEEENAMFTGDNVLGHGTSAVELLSLWMSSLRKMQSHNCAVGYPAHGEVITDLPAKINGELAQKARRERQVLQTLSRIKREERSAGRGKGSVTVKQLVTAMHGDELDSEVRELALEPFIDEVLRKLAEEDKVAFELRRGEKRWFGVDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0X5</accession>
    <name>A0A194X0X5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_159178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067867.1">
        <property type="nucleotide sequence ID" value="XM_018205483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0X5"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="36"/>
            <end position="47"/>
        </location>
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            <end position="89"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="161" mass="17527" checksum="24E6EC4C1BFBA0AB" modified="2016-10-05" version="1">MSRLLPRRFLLPSRRLFTHSTRRTAFATGPAPPRLPPKEQEEFERLQKSSTGAFSTPKAAGTTSPSAESFSPPRTRPQINQSPASTPEKATTEAAEINARVAASGKGEELHPDIRRGAAPEFEGDVNPKTGEVGGPKNEPLRWGSTGERGDWSYNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X213</accession>
    <name>A0A194X213_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_649943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_649943"/>
    <dbReference type="InParanoid" id="A0A194X213"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267808" evidence="2">
        <location>
            <begin position="17"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="695" mass="76389" checksum="587450E1B29474FE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2X2</accession>
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            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="133"/>
        </location>
    </feature>
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        <location>
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            <end position="44"/>
        </location>
    </feature>
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        <location>
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            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="947" mass="105435" checksum="01AA7E399B32B7B6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3E6</accession>
    <name>A0A194X3E6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="13" type="ORF">LY89DRAFT_686831</name>
    </gene>
    <organism evidence="13 14">
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
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    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068702.1">
        <property type="nucleotide sequence ID" value="XM_018215372.1"/>
    </dbReference>
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        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3E6"/>
    <dbReference type="GeneID" id="28825098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686831"/>
    <dbReference type="InParanoid" id="A0A194X3E6"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
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        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
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    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="44"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="116"/>
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        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="122"/>
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            <position position="261"/>
        </location>
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    <feature type="active site" description="Proton donor" evidence="11">
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            <position position="263"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KUJ14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="52388" checksum="68C5C44233E2902F" modified="2016-10-05" version="1">MADTEASTRAGRPSFGSNMRSRSYLQEHQQYRPPQQDGHQGIDSIVEGMQSTKIDQSKPIHKYNGVPSPKSPPKIIDSGLSHTLSHTNCQPAPGTYSDRLIATIIYKTQSPRAKITDIPLDRTPSPTAPTTSRTLPPNLAPVRTLSNFPLEPPPPDPEPLDHLYGSYISPLCLTSFLHLITSLPTRQGSETLTSSHRCLDNPEHPCIVELTFSPSPDPTYVDLDDLRKHELIYRFEREWNVDVILQLDTVLRRYPRLVCFDMDSTLIEQEVIDLIAASIGVEAEVSAITARAMNGELDFSSSFKERVKLLKGSQADIFTKLRSVIKPTKGVFELIKALKRMGVKTAVFSGGFIPLTQWLADELGMDYAYANTIEADPATNLLTGEVIGTIVNAERKRDLMLEIAEKEKIPLEQVVAVGDGANDLLMMKGAGLGVAWNAKPLVQMEAKARLNGDTLLELLHIFGLTAEEVQTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4I1</accession>
    <name>A0A194X4I1_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">Gaa1-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_708425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018217681.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like"/>
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    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
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        <property type="entry name" value="Gaa1"/>
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        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
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        <property type="entry name" value="Rhomboid-like_sf"/>
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        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="867" mass="96870" checksum="F602E990EAE4F91F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5A4</accession>
    <name>A0A194X5A4_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_686032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069604.1">
        <property type="nucleotide sequence ID" value="XM_018215191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5A4"/>
    <dbReference type="STRING" id="149040.A0A194X5A4"/>
    <dbReference type="GeneID" id="28824917"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686032"/>
    <dbReference type="InParanoid" id="A0A194X5A4"/>
    <dbReference type="OrthoDB" id="3021074at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="678" mass="75860" checksum="A6A4D3484CAE6707" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X605</accession>
    <name>A0A194X605_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_587413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069958.1">
        <property type="nucleotide sequence ID" value="XM_018209430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X605"/>
    <dbReference type="FunCoup" id="A0A194X605">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X605"/>
    <dbReference type="GeneID" id="28819156"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587413"/>
    <dbReference type="InParanoid" id="A0A194X605"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033883">
        <property type="term" value="F:pyridoxal phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="29242" checksum="5E8B15082A1B3BDC" modified="2016-10-05" version="1">MTSTLSKEPRRFAPLGKKSEDAGKVLPKLKGIVFDVDGTLCLQQNYMFGEMRRALGIDKGTDILDHCHSLPPTEEEAALEKIRTIERTAMTKQEPQPGLATLMEYLESREIPKGICTRNFETPVAHLLEKFLPGKKFDPIVTRDFRPPKPDPAGILHIAKSWGFVKVGEGGDVGDASNMIMVGDSIDDLTAGFGAKAATVLLVNEANAHLAGHEHTDLIVSRLDELIDILENGFVGRIGREDEESDTRKRAEEVLKEGRAEGTTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7W7</accession>
    <name>A0A194X7W7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_78510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070616.1">
        <property type="nucleotide sequence ID" value="XM_018222855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7W7"/>
    <dbReference type="GeneID" id="28832581"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_78510"/>
    <dbReference type="InParanoid" id="A0A194X7W7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="191" mass="21073" checksum="97D06E58F3EACF5F" modified="2016-10-05" version="1">MQCNYPANPDDGSAHDLIATEVAFDGINTFQCQQRCLANSECKSFQFGAACEIFNKTIAEAHIKHNGSSTNLYFDRDCPQYQYVNYSHSKPVRYKKTDWDDTKPGCPAGDHIKRVPASQTPSELKTLPPNEISSICTCLVASVPTAVTKTIINSLILSAFTTETFTTTALTTVTAYPKNLISWTTSYSLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X821</accession>
    <name>A0A194X821_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_669841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070668.1">
        <property type="nucleotide sequence ID" value="XM_018213131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X821"/>
    <dbReference type="GeneID" id="28822857"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669841"/>
    <dbReference type="InParanoid" id="A0A194X821"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000135">
        <property type="entry name" value="Beta-galactosidase, putative, bgl35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.20">
        <property type="entry name" value="putative beta-Galactosidase from caulobacter crescentus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 42 N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="4">
        <location>
            <begin position="394"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="566" mass="62821" checksum="82DCF0DBF97D45AC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8C1</accession>
    <name>A0A194X8C1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cip1-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_559467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070392.1">
        <property type="nucleotide sequence ID" value="XM_018208437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8C1"/>
    <dbReference type="GeneID" id="28818163"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_559467"/>
    <dbReference type="InParanoid" id="A0A194X8C1"/>
    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267968" description="Cip1-like core domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cip1-like core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="232" mass="24801" checksum="EAE777A3FA86BEC0" modified="2016-10-05" version="1" fragment="single">FRQIALLAALAVLPTSLAQISANFDNGWDQTLWPIYAPDCNQGGTVTLDTTTGHSGTSSMKVTSPGGYCGHIFFGTTAVPTGDVYVRVWLKATNALTANHVSFITMPDSAQGTGKHLRIGGQDQVLMYNRESDDATLPDMSPQGTATSEALPTGAWECFEYHLGTDGSIETWLNSAAIPGLTTKGNANDNGWAKSTIIPKVTGVYFGWESYGGDVNTFWYDDISVQSTRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAK1</accession>
    <name>A0A194XAK1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_73602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071550.1">
        <property type="nucleotide sequence ID" value="XM_018220077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAK1"/>
    <dbReference type="GeneID" id="28829803"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_73602"/>
    <dbReference type="InParanoid" id="A0A194XAK1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11553" checksum="E141BDB5556D13F1" modified="2016-10-05" version="1">MHRQCHLHCFYSYDHLLSTPFFLSFFLSFFLLRLLISLPPYLELPQNLLRPCRKILLQLPKSQISKNSYTLAYKIMSGSLIYAPDWLRLLAFSALSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB21</accession>
    <name>A0A194XB21_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_585731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071302.1">
        <property type="nucleotide sequence ID" value="XM_018209336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB21"/>
    <dbReference type="STRING" id="149040.A0A194XB21"/>
    <dbReference type="GeneID" id="28819062"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585731"/>
    <dbReference type="InParanoid" id="A0A194XB21"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="20654" checksum="BCB2C23AF0546C01" modified="2016-10-05" version="1">MISTAEAIEKEKKISLMDLPTELHLQIASYLTYPDALSLKHTSRHFYGFVYTGVNLKVEWLIKRRILHLDCPHDRGCELGSDMRFCRGSVRLLMKRRREHGECETREGGRGCLVFETKVCTYRKERMGRFEVFREWMTSSKKRREVLWWILVTIMGIVLAGGLMLMRNWLGVGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBD0</accession>
    <name>A0A194XBD0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_615589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071819.1">
        <property type="nucleotide sequence ID" value="XM_018210731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBD0"/>
    <dbReference type="FunCoup" id="A0A194XBD0">
        <property type="interactions" value="851"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBD0"/>
    <dbReference type="GeneID" id="28820457"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615589"/>
    <dbReference type="InParanoid" id="A0A194XBD0"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000018">
        <property type="entry name" value="Type II DNA topoisomerase VI subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="242"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ17464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="428" mass="48376" checksum="43524E234AF978BC" modified="2016-10-05" version="1">MDIDLLSDTPEENQLLLLPNVLPHLPSTLITEEPSEFLHENLLHTEISEPDVSALSVPAADAHQSVITKIEVVFESIADCILSGRKELEIQLKSRTTWKETAVQNGVDGTRPKKSHLRKIKFPSKCPIEAWRFTVLCRILELSHEALISGVVTTKRDIYYRESELFTKQSIVDRYVDDIAYTFGINRDALNVAAAAKGLMIGNLSVTKRGGHRIEYWSEPEGILIPKSDDLEDVYLGGTRWIVVVEKEATFRSLAACRYWQNCIAGNGILITAKGYPDIQTRQFLHFLATRFPRIPIYALVDFDPDGIGIMSTYKHGSKALAHEKNVAVPSLHWLGIRSLDFTTDDSVQGLLSLTKRDRNIAKKMLARQDVETGDQEWRRELQMMLMLNMKAEIQILGNEDKLSIWLDRKLSEAVYDADGDISMSQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBN4</accession>
    <name>A0A194XBN4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_584083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071923.1">
        <property type="nucleotide sequence ID" value="XM_018209250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBN4"/>
    <dbReference type="GeneID" id="28818976"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584083"/>
    <dbReference type="InParanoid" id="A0A194XBN4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="400" mass="45581" checksum="877C80F7A2C78944" modified="2016-10-05" version="1" fragment="single">GHGKGVEGFGKSSWYDAFNTTEESLFSTRSKKRHAMKRRMVAHGFSAQSLQLFEQFVDEMMEKFMGKMDEFARTQQPFDIYFWFELFTMDLMGELALGKNFGAIEAGKPAKYSSLVEQSQRFSNISGVLPFGKANVKVLSWVPIPRIQELWKARVEYLEFARTALEKRFRDDRKELVPSGKARQDIMQRFSTSNTTLVWVAGASTGSVTMNWMTYYFCKNPEVKNRIIKELENMFPENVDGSQILPFVKLQKLALLENAEIECLRLHPPIGYSMPRDTPPQGAVICGHYIPGGVAVGVPAAIIGRNETVYKNANTWSPDRWTDETADLATMKTCFLGFGYGSRQCIGRNVANQFVMKMMATLLLRYEIELEDPGLVLGTKEFTIQKPDRKYNVIIRPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBQ7</accession>
    <name>A0A194XBQ7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_57892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071948.1">
        <property type="nucleotide sequence ID" value="XM_018208974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBQ7"/>
    <dbReference type="FunCoup" id="A0A194XBQ7">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBQ7"/>
    <dbReference type="GeneID" id="28818700"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_57892"/>
    <dbReference type="InParanoid" id="A0A194XBQ7"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000008">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000023">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ17593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="527" mass="58215" checksum="F1E120CF11AB48E6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBS1</accession>
    <name>A0A194XBS1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_645186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071963.1">
        <property type="nucleotide sequence ID" value="XM_018211868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBS1"/>
    <dbReference type="FunCoup" id="A0A194XBS1">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBS1"/>
    <dbReference type="GeneID" id="28821594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645186"/>
    <dbReference type="InParanoid" id="A0A194XBS1"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000144">
        <property type="term" value="P:positive regulation of DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="50141" checksum="D60A4BC0513E9584" modified="2016-10-05" version="1">MADPKLVWNQENIRDVAESVGIPNLSDETVKVLAQEVEYRVGQVIVEAMRFMHAGKRTILGTQDISQALKVLDVEPLYGYESTRPLRFGEASLGPGQPLFYIEDEEVDFEKLINAPLPKVPRDVSFTAHWLAVEGVQPSIPQNPTTAEARANELVPKGPGANPTLGALAGNDNVTFKPLVKHVLSRELILYFDKVRAAILDESQDPEIVILRKSSLKSVQSEVGLQQLVPYFVQFVSEKVTHSINNLFVLRQMMELTQSVTENKNLFIEPYIASLVPPILTCLLGRTFGAPGLDNLKEQYQLRDLAASLIGHISNKYSKSSGDLQSRLARTCLKYFLDPTRSLAEHYGAISGITLIGGPSAILTLILPTMKTYEYVLTKAQNERGANDESLRMLIGAIMKGIMTIAESPTQMMNGLNGNAAEGQLVEEYLGSTIGSRVVALGNHKLNKAILDSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD64</accession>
    <name>A0A194XD64_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_781185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072446.1">
        <property type="nucleotide sequence ID" value="XM_018222458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD64"/>
    <dbReference type="STRING" id="149040.A0A194XD64"/>
    <dbReference type="GeneID" id="28832184"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781185"/>
    <dbReference type="InParanoid" id="A0A194XD64"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="79" mass="8614" checksum="75B82EA9F7650CA8" modified="2016-10-05" version="1">MPSEDSKQDKQTSAAQAKQVIDVFQEISTLLNADLDRQTLSICISLIENGVNPEALAAVIMELRKDAEATKRRLEAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDK4</accession>
    <name>A0A194XDK4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_42744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072589.1">
        <property type="nucleotide sequence ID" value="XM_018207448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDK4"/>
    <dbReference type="GeneID" id="28817174"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_42744"/>
    <dbReference type="InParanoid" id="A0A194XDK4"/>
    <dbReference type="OrthoDB" id="5204927at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="316" mass="35486" checksum="71868AC6834F47EE" modified="2016-10-05" version="1">MAKVAGTLPPPPVERPALKGPTRSMTHPLRDPKTSGPRRKVKSGEPFDPEELSRRLQAHIVEQKIKSEKRREARAAKAAAAEAALHAQNGYHHVPATAAASFERTTTQAKPLKMHKLAQPVVKAHLDRVSIENERQPLTLLQKTVAMDQAMLDAHLLRNRNQFQWTQEMEEAAEADSERDLYKVPQRTFNGEFAHLIGNHKKGAPRPMSTGDLFWEEEASSPPPVPKQKVKPAPHEIVNDHRNDWAQRDDEMENRKKEKASPFLKKMESSWMLIGKKEKGVKPERRDEGIAGLGSSPPDGKGVKGSFLARFKRHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEK1</accession>
    <name>A0A194XEK1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_499413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072929.1">
        <property type="nucleotide sequence ID" value="XM_018207952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEK1"/>
    <dbReference type="GeneID" id="28817678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_499413"/>
    <dbReference type="InParanoid" id="A0A194XEK1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="124" mass="14151" checksum="C6A125F9267F04B0" modified="2016-10-05" version="1">MIIDSISELEIFMRPVCFVLLLLPSIYASMTNLLPGLERLSLSRSNVRIGFIVTQSKQECFLKHCSLSQSCLLTLKTTYIFSDHIFLPLMTSYIRIYHDILVLPLAPQSFKTHQTSSFHGNVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFP5</accession>
    <name>A0A194XFP5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_581933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073321.1">
        <property type="nucleotide sequence ID" value="XM_018209133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFP5"/>
    <dbReference type="STRING" id="149040.A0A194XFP5"/>
    <dbReference type="GeneID" id="28818859"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581933"/>
    <dbReference type="InParanoid" id="A0A194XFP5"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268180" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="18512" checksum="6DCDEB32EE63E4B8" modified="2016-10-05" version="1">MFYARFLVTALAAATVSAKSTAYLIRHGEKPSDGSDGLSAQGMQRAQCLRTVFGASSSYDIAYIIAEQPKASGARDRPLMTVQPLATDLGLTVDTSCDRDDQKCVAALVDVYTGSGNILICWEHGQLTNIVDALGDNNAPTYPDGSFNIIWTDPSPYSSITSMTSEDCPGLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGS9</accession>
    <name>A0A194XGS9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_773666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073701.1">
        <property type="nucleotide sequence ID" value="XM_018221944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGS9"/>
    <dbReference type="GeneID" id="28831670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773666"/>
    <dbReference type="InParanoid" id="A0A194XGS9"/>
    <dbReference type="OrthoDB" id="3546014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="524" mass="57604" checksum="5427CA87F2205A42" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH33</accession>
    <name>A0A194XH33_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gag protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_773187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073437.1">
        <property type="nucleotide sequence ID" value="XM_018221927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH33"/>
    <dbReference type="STRING" id="149040.A0A194XH33"/>
    <dbReference type="GeneID" id="28831653"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773187"/>
    <dbReference type="InParanoid" id="A0A194XH33"/>
    <dbReference type="OrthoDB" id="3560282at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21055" checksum="75C538A059DA934D" modified="2016-10-05" version="1">MLYLFDQTTGDAQKHLQPRYDQDSQTRFVSAQEMLDHLAAIYVNPNQVRDARYEYNRLLMMIGQPFAEFQTQFLHLAGQAQTPAEDLRLDLYDKLTTQLQRGIAPNLRSLDTYAELAASCQSLDTELKRITARESQQRRQRSTVISPPAIPPASTTTRLTSTIPTGLRLDSTTMKASKSPNDLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH83</accession>
    <name>A0A194XH83_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_612640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073487.1">
        <property type="nucleotide sequence ID" value="XM_018210631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH83"/>
    <dbReference type="FunCoup" id="A0A194XH83">
        <property type="interactions" value="960"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XH83"/>
    <dbReference type="GeneID" id="28820357"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612640"/>
    <dbReference type="InParanoid" id="A0A194XH83"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ19132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="653" mass="70970" checksum="637AAECEF74CF8B5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHE5</accession>
    <name>A0A194XHE5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_581412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073547.1">
        <property type="nucleotide sequence ID" value="XM_018209109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHE5"/>
    <dbReference type="STRING" id="149040.A0A194XHE5"/>
    <dbReference type="GeneID" id="28818835"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581412"/>
    <dbReference type="InParanoid" id="A0A194XHE5"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32052" checksum="87DA2EC4AB9BF41B" modified="2016-10-05" version="1">MSTASTPGSAPKTMSSRLLTMKFMQRAANTSPTSRAEPSPDEPSAKRRKTDSSPSTPTKFNVDALADRSAIQTALADEEAKRQAALERQAAELGDTRWVLSFEDQQNLAAAPPLALRVVQTGFANLDASPVRVQYMDDDPEEKPVMIGRRSFGKFNKVVEKRQDPNAEDTSESDSEADEEDDSSEGESESDDPASELIRASREEAAERAKAERKAKKRAAKAELEEMAKKRRKTEVNLNGLSSLSGRQDRKPPVAKNCYTCGGNHYKKDCPAKKRGHQGGDDGPPRKSRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ03</accession>
    <name>A0A194XJ03_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_779950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074454.1">
        <property type="nucleotide sequence ID" value="XM_018222343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ03"/>
    <dbReference type="STRING" id="149040.A0A194XJ03"/>
    <dbReference type="GeneID" id="28832069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779950"/>
    <dbReference type="InParanoid" id="A0A194XJ03"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="546" mass="60950" checksum="832F4379C3488778" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJJ6</accession>
    <name>A0A194XJJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_440606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074683.1">
        <property type="nucleotide sequence ID" value="XM_018207536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJJ6"/>
    <dbReference type="GeneID" id="28817262"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_440606"/>
    <dbReference type="InParanoid" id="A0A194XJJ6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="30549" checksum="2F15D62AFDDED08C" modified="2016-10-05" version="1">MEVDGSARFAPNGVVLERSTLHQQSCCPGIINRVSQLRPSLLCLPSLYPADKRCAGRRDQPCSCCNRCNNAGLAGATCTVRMFEMLQETRQRSAVQYDADALLGSYGMNGWMVGRWPALPHEEPAGGSLAQELRPQPGCQDWTVQDRTEPETGPNRPDARRTTARSRSRSSALCPGRAKRRTTEGFLTTADNDWRAELAGWLSRKKDGDDDCDWDWNRDRKRGLGDVRQKRAVMSLTPELDLELELEPAAAAAGDPSEGCFYGSAVDWARVEETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJQ6</accession>
    <name>A0A194XJQ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_682819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074367.1">
        <property type="nucleotide sequence ID" value="XM_018214575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJQ6"/>
    <dbReference type="FunCoup" id="A0A194XJQ6">
        <property type="interactions" value="1131"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJQ6"/>
    <dbReference type="GeneID" id="28824301"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682819"/>
    <dbReference type="InParanoid" id="A0A194XJQ6"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synt_IIb"/>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
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        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
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        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="201"/>
            <end position="548"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ20012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="662" mass="74158" checksum="B45504AD2E6BC5D4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKN1</accession>
    <name>A0A194XKN1_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_578989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074702.1">
        <property type="nucleotide sequence ID" value="XM_018208979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKN1"/>
    <dbReference type="GeneID" id="28818705"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578989"/>
    <dbReference type="InParanoid" id="A0A194XKN1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="45"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="32088" checksum="A3090B6EACF000E4" modified="2016-10-05" version="1">MSTRIPEPAYPARNAEALYGDKSLYAKLGEIAEKQGGKTIIEEFEIPIRSGKAWVVKKGQLCKLSTPRGPQVGDLNIWSLHNPRERFWASRTKQLHASHVSVGDRLWSVLPYMRPLVTIVADSLKEYGVDEVGGRCHDLLGTRCDPYVNKLLSGDDFDFQCHSNLVRAVLPYGLTEADVHDVINVFQVTGLNKDGKYFMEASPAKPGDYFTFFAETDLLCAMSACPGGDLSVYGWGGDSAQRMLETCRPLGVAVYEIEGKEEVLKDWKESQPPGYKGMHGLKIPVFGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLD0</accession>
    <name>A0A194XLD0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_730614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074937.1">
        <property type="nucleotide sequence ID" value="XM_018219497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLD0"/>
    <dbReference type="FunCoup" id="A0A194XLD0">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLD0"/>
    <dbReference type="GeneID" id="28829223"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730614"/>
    <dbReference type="InParanoid" id="A0A194XLD0"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="379"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ20582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="483" mass="52660" checksum="E9C0B53AFF7C735F" modified="2016-10-05" version="1">MAAAVVAHDQKSQIEHLQGLIKENAKRSRALFADGQSEKQDDFTEAADKLVIAARIHSEYDHVRELPPALAAKFANAVGSRKKAKTATEPTEADARTTKLIEGVASKSEGAGSSSTALTIRRQGPADGTPPNANGPTAQKNLPSSSLVRKQTVVQVKPDWHAPWKLMRVISGHLGWVRALAVEPENKWFASGAGDRTIKIWDLATGSLRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLSLHPTLDVLVTGGRDGVARVWDMRTRSNIHVLSGHKGTVSDVKCQEADPQVITSSLDSTVRLWDLAAGKTMGVLTHHKKGVRALAIHPKEFTFASGSTGSIKQWKCPEGAFMQNFDGQNSIINTLAVNEDNVLFSGGDNGSMSFWDWKSGHRFQALDTTAQPGSLDAEAGLMSSTYDKTGLRLICGEADKTIKVWKQDESATPETHPLEWKPTLGRQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLG1</accession>
    <name>A0A194XLG1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_770286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075435.1">
        <property type="nucleotide sequence ID" value="XM_018221843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLG1"/>
    <dbReference type="FunCoup" id="A0A194XLG1">
        <property type="interactions" value="1320"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLG1"/>
    <dbReference type="GeneID" id="28831569"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770286"/>
    <dbReference type="InParanoid" id="A0A194XLG1"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="465"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="858"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ21080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137587" checksum="A6BBD0C0056F6AF9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLP7</accession>
    <name>A0A194XLP7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_577963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075458.1">
        <property type="nucleotide sequence ID" value="XM_018208922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLP7"/>
    <dbReference type="STRING" id="149040.A0A194XLP7"/>
    <dbReference type="GeneID" id="28818648"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577963"/>
    <dbReference type="InParanoid" id="A0A194XLP7"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36371" checksum="6BBBC8506A243511" modified="2016-10-05" version="1" fragment="single">MAGNDTIRSVVGWQPNSDRRGTLAILESCIFTILACTWTILHLNVPGPSDSAFRILRRKMALAIITVFLPEIILAHAMMERSAAILSLQELKALDIEDLEWTLRHSYYANMGGLRLVLEDGGVICSFTIAAFTSIALTTRQFGYLREKGVITSTPNILEGEIEDKAKTDYFTKGIAIVQIFWLILSLCGRASRHLAVSQLEILTVAFAACAAVTYFFAWDKPQGVNTGTKVHATAPLNIVDTNRIAQLQPKALNILLFGATDIREGPQFERIHNDTIELSNSYTQPVSLWLTVSIMLFGAIHLSAWNYTFPTPTERVLWRTASVVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM85</accession>
    <name>A0A194XM85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_639144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075554.1">
        <property type="nucleotide sequence ID" value="XM_018211604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM85"/>
    <dbReference type="STRING" id="149040.A0A194XM85"/>
    <dbReference type="GeneID" id="28821330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639144"/>
    <dbReference type="InParanoid" id="A0A194XM85"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="448"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="654" mass="74854" checksum="717AE282230BC02D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN74</accession>
    <name>A0A194XN74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_681025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075899.1">
        <property type="nucleotide sequence ID" value="XM_018214190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN74"/>
    <dbReference type="GeneID" id="28823916"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681025"/>
    <dbReference type="InParanoid" id="A0A194XN74"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="129"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="530"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="668" mass="74229" checksum="82868F096A408DF4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT3</accession>
    <name>A0A194XNT3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_432741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075747.1">
        <property type="nucleotide sequence ID" value="XM_018207486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNT3"/>
    <dbReference type="GeneID" id="28817212"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_432741"/>
    <dbReference type="InParanoid" id="A0A194XNT3"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="714" mass="80009" checksum="EF09D7DBB77AAB68" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNU3</accession>
    <name>A0A194XNU3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_577667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075757.1">
        <property type="nucleotide sequence ID" value="XM_018208908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNU3"/>
    <dbReference type="GeneID" id="28818634"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577667"/>
    <dbReference type="InParanoid" id="A0A194XNU3"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="28175" checksum="6C69B332045564E8" modified="2016-10-05" version="1">MTAAAERRRVALPHERNADGTVTIRAFEGAILSRVLPAPAGRAFNFEVIFFPNHPRLRQLPSKPPEHFHPLQEEYVSVSEGALAVEVEGIEHILRPGDPEFVLQRGVNHRLYPAPQNEKESQNDKSRKVSCLLSAEGTSSLFALDLVFFENWYTYQEQVVVHGAKLNLIQVMAMFDAGDSYLTLPWYIPMRSLMSRVMGIVFGRWIGSLLGYQPFYKEWTTDWDLACEKMETCMLQRRFSDRKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP30</accession>
    <name>A0A194XP30_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_729412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076276.1">
        <property type="nucleotide sequence ID" value="XM_018219380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP30"/>
    <dbReference type="STRING" id="149040.A0A194XP30"/>
    <dbReference type="GeneID" id="28829106"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729412"/>
    <dbReference type="InParanoid" id="A0A194XP30"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="691" mass="77978" checksum="10E0E1C315D825A3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP89</accession>
    <name>A0A194XP89_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_729071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075907.1">
        <property type="nucleotide sequence ID" value="XM_018219340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP89"/>
    <dbReference type="GeneID" id="28829066"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729071"/>
    <dbReference type="InParanoid" id="A0A194XP89"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="31087" checksum="BB47A9F3114CB39D" modified="2016-10-05" version="1">MTGNIKRAFHDAPLGQIHYRYIFTSATEKKAPVVFLHQSASCGWCYQSMMKDFGASYDPVEDSTSTRYYVDIFMGLFRHLRLPKMHLVGHHSGAALAMEMSAVYPSEVFTCALSGPALAIPEEQAKMFKNLARELSKPKEDGSHLMKVWNLMNGELYTDLDIKNHEVIDTLRAWKGRDQAYAVTFKQNKLAYYEKITVLILAMCSEEDVLWPCFHYCQKLVSLKLCKGIKALTGNVQQPNARCEITTSNFIDDSKDIKGSIAYYHVDFLEKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPC0</accession>
    <name>A0A194XPC0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_575944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076450.1">
        <property type="nucleotide sequence ID" value="XM_018208818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPC0"/>
    <dbReference type="STRING" id="149040.A0A194XPC0"/>
    <dbReference type="GeneID" id="28818544"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575944"/>
    <dbReference type="InParanoid" id="A0A194XPC0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="6">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="36409" checksum="BC07E8B921C71827" modified="2016-10-05" version="1">MYVGGIAVASLPNNTDTYIVLIASGNYTEQVNVTRRGPTYLLGQTMNPMNQSYNTVNIIWRAIAVTGLDNAFTSTLTIAPNLNASLTGSGTTGFAVPADTPFGCVDFRTYNLNLINDYAPYSDDPSLALSISYANGGFYYTGFYSYQDTIYVGKLGNAYMHSSTIAGETDFFYGFGTLWVQSCSILLRNCGGGITAWKGTNTTFENKYGVYIVDSAVHAANASIAAVIKGKCALGRPWNANMRAIFARTYLDASILSTGFIDWNPARYDNYTLQAEYRDFGPGYNVTGREVARFDVQLNESGWAPYSSPQKVFQYQGTGRFGNTGWIDWGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPZ7</accession>
    <name>A0A194XPZ7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_394756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076484.1">
        <property type="nucleotide sequence ID" value="XM_018207221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPZ7"/>
    <dbReference type="GeneID" id="28816947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_394756"/>
    <dbReference type="InParanoid" id="A0A194XPZ7"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="34426" checksum="E0E1154DFA546F7B" modified="2016-10-05" version="1">MTLTYRNDVSIAELVFYIPSLFVAIYLAITHGFRRNSGWIYLILFCLARIIGPIMQLATIKNPDSVSLYTGSAILNSIGISPLEIATLGFLSRLLDSIHKSYNTFLHPRMLQLVQLIIVIGLILGIVGGIDAGNNFQSTGQYHPGTLNKAGTSLLIVSYVAIVIFTILIAFFVKHAEAGERRLFVAVAIALPFLLVRIVYSGLSTFSRNSRYNILTGNTTIFLCVALIEEAIIVFIFEVMGVTLKKQVKEQHVEAQAARQVDSSNSAQPMQPKKEHMALSIAKKTIIGRIVMAIIGSGKKEERNTEMQQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ93</accession>
    <name>A0A194XQ93_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_295182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076718.1">
        <property type="nucleotide sequence ID" value="XM_018206539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ93"/>
    <dbReference type="FunCoup" id="A0A194XQ93">
        <property type="interactions" value="1107"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQ93"/>
    <dbReference type="GeneID" id="28816265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_295182"/>
    <dbReference type="InParanoid" id="A0A194XQ93"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000094">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="10">
        <location>
            <begin position="177"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6/ORC1-like ATPase lid" evidence="11">
        <location>
            <begin position="327"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="9">
        <location>
            <begin position="473"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ22363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="624" mass="68255" checksum="02C3CA06DE1395FC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR39</accession>
    <name>A0A194XR39_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076874.1">
        <property type="nucleotide sequence ID" value="XM_018214120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR39"/>
    <dbReference type="GeneID" id="28823846"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680662"/>
    <dbReference type="InParanoid" id="A0A194XR39"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="13403" checksum="F6E61E5A1EC8F01D" modified="2016-10-05" version="1">MSEVRKSTEVSHGRGGAGNISEDATPYGDGEIVREGIVGDHGDGAFSTGRGGAANIGSPGLKATQRKDDIAIPETALRPSQENEVYHTGRGGEGNVHTAEPVTKHPEGLADKLKNKLFKKKAAKEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR78</accession>
    <name>A0A194XR78_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_574809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077011.1">
        <property type="nucleotide sequence ID" value="XM_018208762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR78"/>
    <dbReference type="GeneID" id="28818488"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574809"/>
    <dbReference type="InParanoid" id="A0A194XR78"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="37820" checksum="99582975DE8E18D5" modified="2016-10-05" version="1">MATQQSSSSVCRGQRTLGALRHLWRLSQLTQSPSSPPPLPQTTPERLASTSEKTILYLAYGSNLSAETFKGARGIKPISSVNVHVPSLDLTFDLAGIPYIEPCFANTRWRDQNAPPSDDDYHKDRWHKGLIGVVYEVTPEDYRIIIATEGGGASYQDVVVPCYAIPPGTSEVDPLPSGSPFKAHTLLQPTDDESNRIRTRAGRIHRPDPSYAQASARYLKLITDGAEEHSLPEEYLHYLHNIRPYTITTRRQHLGQAFIVGFWSPLILALFGLGKLFADDEGKIPAWLASIMGTVFTIMWMSYDKLLKPAFGDGERTMGDDDEEKCRTVKWCEKSVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR83</accession>
    <name>A0A194XR83_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_777719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <location>
            <begin position="83"/>
            <end position="103"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="110" mass="12331" checksum="85889CA936730C38" modified="2016-10-05" version="1">MPQPTSPAHPSPTLRQQVLTLDAALATNLKHITKQRQQLIARGLVPATAIICDGCGGEKIGSCDKKGEKEDEEVKKEYEKKKWVEYGVIVVVSVAVIVVWKVVERVRRWR</sequence>
</entry>
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        </submittedName>
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        <lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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            <end position="714"/>
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            <begin position="87"/>
            <end position="97"/>
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        <location>
            <begin position="456"/>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22873.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="714" mass="70340" checksum="DD78E51D86E9E39E" modified="2016-10-05" version="1"> </sequence>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27368" checksum="33F680355AC6670B" modified="2016-10-05" version="1">MYTIASTSIVNSLTTFVACCPSSYTFYGTQYETLDPIFQCASSVSIGQTLKFDIVTDIDVFVTNTTVNKDIYFSVYAVPINGYVFADATTSTSQSKTSTAGAIVPQTPTIPQTSTPLPATTSISTLNVNSSTSGLSTGAKIGICVGTSLAVLGFCGLIVAFFLIRRSKNSIRQHERGSLMETRALTPELPDSETIRRKPVASQRASATTTATQTTSPRAPDTIWEDPDASNEGEQVQQEGVHEMGATLQVPFSDSNA</sequence>
</entry>
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    <accession>A0A194XTL2</accession>
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28815330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_180386"/>
    <dbReference type="InParanoid" id="A0A194XUH8"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="136" mass="15334" checksum="A32ABB7A92932D53" modified="2016-10-05" version="1">MGKRRFRRIISAAFAFTSALMVLVPRENGMFDKGERGEKNKDREILEGTARDGWEGGRCLQVHSSSSSNMHYKGQGRERGRERYHLGRESRDPKIGDSKASQAWIVYVYSNGKHISVQSNKNPSITQTAHSHVASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVV8</accession>
    <name>A0A194XVV8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_662645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078207.1">
        <property type="nucleotide sequence ID" value="XM_018212660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVV8"/>
    <dbReference type="GeneID" id="28822386"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662645"/>
    <dbReference type="InParanoid" id="A0A194XVV8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="34472" checksum="6A9502C84A94E45E" modified="2016-10-05" version="1">MNREFNQNPELVPRLKLNITISGAINVAGTPYNLHFYAGDLTEAEDSVPSSPAGKVFESSNSSEAGDLFLSKDESSGFFDLHNNRQEQLPSRSGTTTRNPRGQTYVYPNRADFEPTPGIQHHHSHQSLIETPQLGAGVFGSLGAFLGFMSPVSRERAIPQGSRTLTNEDYERDPDYVQAMINRHLFEKPAKWHLVWQDQDNGKDNDKLGNFSGSLYANDKPHCPGIGCGGTAGIRRLRDCAKNHWICHKCGPDGWRDYKAEPTSNVVRNEKKCTRCSHEHCKQCPDRGNLGFYYVKEAMKKFPEKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW43</accession>
    <name>A0A194XW43_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_634565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078813.1">
        <property type="nucleotide sequence ID" value="XM_018211395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW43"/>
    <dbReference type="GeneID" id="28821121"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634565"/>
    <dbReference type="InParanoid" id="A0A194XW43"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268728" evidence="1">
        <location>
            <begin position="17"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="43"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="56765" checksum="53293C7722D52D86" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWE1</accession>
    <name>A0A194XWE1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_776474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078694.1">
        <property type="nucleotide sequence ID" value="XM_018222050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWE1"/>
    <dbReference type="GeneID" id="28831776"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776474"/>
    <dbReference type="InParanoid" id="A0A194XWE1"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="26531" checksum="AC61AB1ED5E75029" modified="2016-10-05" version="1">MSSATKPFPFLELPPEIREKIYILICHQSAPISLHIPISTPCETSSDPSFPHALLQTCTLIYNELRPIYFTHNTFTLSIRRRNDDLTYFLSPSFLDNRRQIRSLKLIIYRFGGHDFFTKDFIPVLEDCIMNGRLRDLDVVVKERFLRSVKLCERGLRGGFRDTAGLETLRDWVALRRVLLDPYLEKRLLRSGNLDAVDSVNQENIELTLMGVPGYEEHPDYQLESYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWF4</accession>
    <name>A0A194XWF4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_572803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078985.1">
        <property type="nucleotide sequence ID" value="XM_018208658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWF4"/>
    <dbReference type="GeneID" id="28818384"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572803"/>
    <dbReference type="InParanoid" id="A0A194XWF4"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45361" checksum="9AE3EB783193AECF" modified="2016-10-05" version="1">MLLGTESEQQQQRKHHRYLGLWRKAHTITGLITLFASFILIIIGASKLYLLLFGSSTSNSPSFPLKELADKQVCGTHLSERITKIPNIVHYVWFLKDPTSLHLDFKFFITAYSAYLYFQPDKIYYHTDASFELFERARRSGSEWTQRLLSLPNVEYHYVDAPSVTTKGIPIEKFEHKSDFTRMQVLHEYGGIYMDTDAIPLRDIADLRESGFANVVGGAIGLTMHHSGFINNGVMMAAPGSALMKIYMRAADQFFDGRWETASVNLLTDVANRLSAVPHEVLILQPKAFAPVSWEYADQVRLFQPHFEMPAGNEIWGSTSTNMTTCDDMLSSLIEKESFGGEDWEMDFSSSYVLHAFDGKHIPGWDNKVDLNYILARQSNYARAVYPAIAHAISSGVLGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXN6</accession>
    <name>A0A194XXN6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_776674</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078947.1">
        <property type="nucleotide sequence ID" value="XM_018222064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXN6"/>
    <dbReference type="FunCoup" id="A0A194XXN6">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XXN6"/>
    <dbReference type="GeneID" id="28831790"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776674"/>
    <dbReference type="InParanoid" id="A0A194XXN6"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="89"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ24592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="445" mass="48132" checksum="FCBB5DFBC60B2F91" modified="2016-10-05" version="1">MSLNDHPKAYGTAAVAVAFAAGILLTLGFKDLYPDLERRYQRRRGGPSSSADSRPASTYLAPVKLEDHTRSARQSIVGVPVPPVPEGIEGCIGNTPLFKIKSLSEATGCEIFAKAEFLNGAGGSPKDRVALNMIQMAEEEGLLTPGRGDTIYEGTVGSTGISLATLARAKGYKAYICMPNDQSKEKSDLLHHLGATVERVTPAPITSTEHFVNLARTRAREHTASNEDESKGFFADQFESLANYRAHFKTTGPEIWHQTGGQLDAFVAGAGTGGTISGISLFLKQEMGMGRDLKVVLADPEGSGLYNKVKHGVMFSSTEKEGTRRRQQVDTIVEGIGINRLTENFEAGRELIDDAVKVTDLQAMKMARWLVEKDGIFVGSSSAVNCVAAVFTALQMPKDSRIVTILCDSGTRHLSKFWKSVGEMGLEEEHEQTNLLALLGIKDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B374</accession>
    <name>A0A132B374_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_692462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060844.1">
        <property type="nucleotide sequence ID" value="XM_018216542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B374"/>
    <dbReference type="GeneID" id="28826268"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692462"/>
    <dbReference type="InParanoid" id="A0A132B374"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287811" description="Solute carrier family 40 member" evidence="8">
        <location>
            <begin position="33"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="46698" checksum="99FAA3B1F6A331B1" modified="2016-05-11" version="1">MTGQSSSPFSSLSTGCLYGLILLLDVIHDLSAIGNRLSLERDWVPVLVGPITPETTYGLTQVNSVMVRLELLVKLIAPSLLPIIMSTFKSREGWILLLVAITLGMWATEVGCARLVARENPELQEPKKISADPATMEDLEIEDQFVHLKPGISSLPKKIYFVLYQDPAVRLRHFFSVSMWPASISLALLQVTVLAYSATMITYLLQTGFSISIITVARASGAITGLSSTVITPWLVGMLRSRYIHRENTNEDGEDDAAEGKVVRTVGLWGIMFQFPAQIPVVLVLWSLSAALPSEMLSRQTDNSTSSPQILVPIIFFAFLSLSRIGHYMNSLMVQELGQVEIPVSQRSTFAGTEQSFRSLGELGHWAATVVWSDPSQFKWLAMGSLLLVGSSLVIFGSWARKSSSKRRAYESVPLNDFEGEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3R2</accession>
    <name>A0A132B3R2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_632043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061385.1">
        <property type="nucleotide sequence ID" value="XM_018211293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3R2"/>
    <dbReference type="STRING" id="149040.A0A132B3R2"/>
    <dbReference type="GeneID" id="28821019"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632043"/>
    <dbReference type="InParanoid" id="A0A132B3R2"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="566" mass="62396" checksum="309528BBADEC92A9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B438</accession>
    <name>A0A132B438_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_691906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061456.1">
        <property type="nucleotide sequence ID" value="XM_018216429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B438"/>
    <dbReference type="STRING" id="149040.A0A132B438"/>
    <dbReference type="GeneID" id="28826155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691906"/>
    <dbReference type="InParanoid" id="A0A132B438"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="27764" checksum="B659FDBF294AA588" modified="2016-05-11" version="1">MDLTSLSTVIEAAKSFASKETKLHGLILNAGIMAPPYEVTADGYESQMQVNYISQWLLTYHLLPIIESTARKEGPGAARIVCVSSHGHREKPFSVQKMLYDKTEIENFGSFGRYGLSKLANVLHAKTLNVQYGPGSEHARQGKGEIWCASVHPGFIATQLNEKNRDNASWKLSWIHPVLKFFGIMRPWSKGCVSNVFVGASPAFTADMCGLYFDEKARVAKENAAARDPNEREKLEKWTVEELKKGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B447</accession>
    <name>A0A132B447_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_368396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061466.1">
        <property type="nucleotide sequence ID" value="XM_018207043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B447"/>
    <dbReference type="GeneID" id="28816769"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_368396"/>
    <dbReference type="InParanoid" id="A0A132B447"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="67" mass="7547" checksum="293968EAE0EB455A" modified="2016-05-11" version="1">MALCAITCYYACIRKDWLVRGRERGEINKCCNARSFVMSLLTILVGATLANMHTSRWIIHLALASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4N3</accession>
    <name>A0A132B4N3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_789813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061717.1">
        <property type="nucleotide sequence ID" value="XM_018223299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4N3"/>
    <dbReference type="GeneID" id="28833025"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789813"/>
    <dbReference type="InParanoid" id="A0A132B4N3"/>
    <dbReference type="OrthoDB" id="3556117at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="681" mass="78037" checksum="22D367A5BE131368" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4Q3</accession>
    <name>A0A132B4Q3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_374386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061324.1">
        <property type="nucleotide sequence ID" value="XM_018207076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4Q3"/>
    <dbReference type="FunCoup" id="A0A132B4Q3">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B4Q3"/>
    <dbReference type="GeneID" id="28816802"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_374386"/>
    <dbReference type="InParanoid" id="A0A132B4Q3"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ06969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="334" mass="37118" checksum="B3A0A94E7ADE42D1" modified="2016-05-11" version="1">MAPELSSNWKKLQAILKQEEKDKPDRKRKEIPTERQRNTIAAKRRRLDLKPSKAVTARPLQLAKKGKMGGAMSVEASESPDPTDSIQPANDAPSASLALWAEDNDISAKDLAEAYGGGLKDTTFKGTKPDKINGGLSRDVEIGKYVGIDCEMVGVGGEEDRSVLARVSIVNFHGTQVYDSFVRPKEFVTDWRTHVSGVSAKNMATARDFEQVQEDVAAILKDRIIVGHAIKNDLAAMMLGHPRRDIRDTSRFSGFRKYSAGRTPSLRKLAKEILGVDIQMGEHSSVEDARATMLLFRRHKSAFDVEHAQRYPPQTAQGTSKAKPNLKRKKRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4U7</accession>
    <name>A0A132B4U7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_790342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061052.1">
        <property type="nucleotide sequence ID" value="XM_018223355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4U7"/>
    <dbReference type="GeneID" id="28833081"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790342"/>
    <dbReference type="InParanoid" id="A0A132B4U7"/>
    <dbReference type="OrthoDB" id="10590139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16206" checksum="00A131A4C3DE589E" modified="2016-05-11" version="1">MLLKIMYSRDTSLIILGVFFSIVALVHGGKMQLMNTPLLATFYPEESYAGFPFKIHAFYDSCYNFHGLVESVTLGKVTEYCDVYAVMDCGENEEKTSYRSITEPTPRMMDKRDGLAVPGLGAIKSMRCYLDEAMVKEQKEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V7</accession>
    <name>A0A132B4V7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_692321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061062.1">
        <property type="nucleotide sequence ID" value="XM_018216514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4V7"/>
    <dbReference type="GeneID" id="28826240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692321"/>
    <dbReference type="InParanoid" id="A0A132B4V7"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="247"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ06707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="582" mass="61974" checksum="9F165440452C1FFE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4W9</accession>
    <name>A0A132B4W9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_789560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061807.1">
        <property type="nucleotide sequence ID" value="XM_018223271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4W9"/>
    <dbReference type="GeneID" id="28832997"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789560"/>
    <dbReference type="InParanoid" id="A0A132B4W9"/>
    <dbReference type="OrthoDB" id="3548295at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287846" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="18761" checksum="6FED357F56179717" modified="2016-05-11" version="1">MMLSMIVTTLLTVLNGFVAAQCTSADRIGYASQVPYAYNLSPLGASAAAFEAIPFNADCQTSIAANGAPAVPVAIDGNTTVVFAVATRQLFSTVTGNYIDFPANGTTDIQTNVTLGVRGIITIPVTFFANVYLDFDDDCTITAVRAFAEVPTVVLGLLLDPPAVPPGILPDDLIMGLLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5C0</accession>
    <name>A0A132B5C0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061222.1">
        <property type="nucleotide sequence ID" value="XM_018216490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5C0"/>
    <dbReference type="GeneID" id="28826216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692222"/>
    <dbReference type="InParanoid" id="A0A132B5C0"/>
    <dbReference type="OrthoDB" id="3561129at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="31616" checksum="DD9B579B6E01D501" modified="2016-05-11" version="1">MPESEEYHGEEQILVLTFFRRSVAPIKEFLKSQGLYPRVEHVDSERIKDGPNAVVIIDVPTSDIVNPYTGDHLSDSRRNEKALVLPSSLRIVVGREDLGQSNDFFAPSTKPSYGESFWLNFVTHHMRQGMVKSVNVGDRILKYERDLESKNYWMVSEYRTEASEMFDAVRFDEEDEDTSIPLVEAGEAGVERLSDHDIERHERSSSVEAGFEISSFDHDAETDQSPQSVMDGNIWKRKELALGSSELNETPSASYDEGSKYGNDIDKLDRIKKSNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6T2</accession>
    <name>A0A132B6T2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_350129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062470.1">
        <property type="nucleotide sequence ID" value="XM_018206915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6T2"/>
    <dbReference type="GeneID" id="28816641"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_350129"/>
    <dbReference type="InParanoid" id="A0A132B6T2"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="512" mass="56408" checksum="4BA0556C4BBF5DF4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B753</accession>
    <name>A0A132B753_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_765907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062184.1">
        <property type="nucleotide sequence ID" value="XM_018221695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B753"/>
    <dbReference type="STRING" id="149040.A0A132B753"/>
    <dbReference type="GeneID" id="28831421"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765907"/>
    <dbReference type="InParanoid" id="A0A132B753"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="365" mass="40838" checksum="3BD38509460C4480" modified="2016-05-11" version="1">MEPLTRTATDARQEPLLQPVDEERPAKKSERSSSSWWWWLEICGAFIALTGLFMTIAVLATLDNKPIDNWKYNIQPSSLLSTLTTVAKMGVMLVVASCVSQLKWLHFQQANRLSHLEMYDQVSRGNPMGAAQMLWKMGRRLFKLRLDIIATAFALVSLLSLAIDPMIQQILAVHQEDLQLNNVTATIGSSHTYISNASQALVLDYFSNNHSCFRRTDRMLPVANTTETLVLHMALLNQLASASLQPDLSCPSPATRCEFSNITSLGLCGNYTDVTDISSRTCKAYPYPSSTIDEITPPPPSHYIDCTYSVQGVTNYRNLTINFGGDDGATFDWFRSILDIIQLDGISDDILNYKPFDIARMFSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7P0</accession>
    <name>A0A132B7P0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter, MCP family, solute carrier family 16, member 10, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_658720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062775.1">
        <property type="nucleotide sequence ID" value="XM_018212486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7P0"/>
    <dbReference type="GeneID" id="28822212"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658720"/>
    <dbReference type="InParanoid" id="A0A132B7P0"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="264"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="50233" checksum="6CC256AB9DD5F55A" modified="2016-05-11" version="1">MSSTITTPSVELQQWPRQQPHQLDQFYVDPEPSHLSQNEASQHNRDVQQYLEPVDRGAAAWRLLAAAFVFEALFWGFPLSFGVFQNYYSSLPQFANDPYIPIVGTVASGISYLGAPLVIPLIKRYSRYQRQMIFAGWPLCLGGLAAGSFSTTLGALIFTQGVMYGVGFLIFYYPILSFVNEFWIERRGMAYGILCASSGISGIMMPFAVEAMLHRYGYPTTLRAIAIGLAVLTGPLLPLLKGRLPPSVHSTAGRTDWSCLKKPLFWVYCASNLMQGLGYFFPSLYLPSYAVSIGLNLSQGALLLALLSISQVMGQISFGYLSDHRLNLNLLIMISTIVSAIASLTLWGLARSLAVLIVFSLVYGFFGAGYVAMWARMGSAVSNEPTAALATFSLFCAGKGIGNVVAGPISAGLILPFTAKESYGAMKYKAVVLFMGSCMIGSTVSVAAWYVRQKRWLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7V6</accession>
    <name>A0A132B7V6_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_725394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08069.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218975.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
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            <end position="500"/>
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    </feature>
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            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
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            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
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        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
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            <begin position="353"/>
            <end position="385"/>
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        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="500" mass="52894" checksum="EF3052F237C729AD" modified="2016-05-11" version="1">MPLTKPRPSELRKSSSMGLFKHKDKTRTDVVSEEPSSNRTSTLSPGQAPQHNNSYHDSAYYSNSNASSADAGSSAAPSQPPPQRQNQPPGTTVTTTTTTTTTTTTVAPDGTTHTYSAPYNPSTDPPPQASETTVDKSLPANAGTNTGISPNPPSQTQNGQQMYNQAPPTIKQTNPTPDQNQSAFQPPSRRLTPKQTQPQYAAPPPPGTLQPQHSGNQAYNGQSAGTQPTYQAYSRPEEDVPPVPLYKTASGGTTSGGRSIPPRSELRNSPGHSPANTTPSPINTQNTSIDSPPMPLRSQKRNSRDGLVAPLNTNPVSELPGNSYHEQPLTPTTPTNAARPKTPNFSRPGVHSPSGSTTNLAQSNMGNTTTISSGVSPVATTTETTPAKEHKLERKRGSVTAAIKGLHGAGEALRGTVNSTIARGMHDTAEEERMRAVRDKGVGEWKGSGLSERVPAGIREGFREKAGDRLTRRRLSQGNGIHGSEGPNGLDPVEERSIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8B3</accession>
    <name>A0A132B8B3_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_676565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213601.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28823327"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676565"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="46927" checksum="2713720271C2BAF0" modified="2016-05-11" version="1">MASTTPQPLNSPTSPIRSSDEPEILPSHRQDNFRPPQHASTFDGFERRVETGFRSLTRKGRKSTHTSLQDWAAKDEPYHRYVRELVAAGWSNLQDLDDYLGRPATQHNEVVSVLDITSATKHHYPDLKTNFELKNFLAVNKRPADTVRIYMAEYKKLPSAELIEAFGSSLHLDRRFFQWSIHSKGHVFTPSQRHRAPYVTLGCGVLDASTARATDVEKFKVLVYIHDGEQTETGWTALFLFSSRTKINMSVELLNDPPPFPSSLPPIRPEFKSFRQLYLDSFDYVNLDYAVKSPFILVSSLFGLNCFCWNQVITTIREEDARVGGISDTTIGHAEEITKTLSAIERGGSYKWHGKDEQPAQARKAELIEDYNHLVDQIKLLWETRDKMADIRKRNSDTRWTALTNAFTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8P8</accession>
    <name>A0A132B8P8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_690780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063130.1">
        <property type="nucleotide sequence ID" value="XM_018216169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8P8"/>
    <dbReference type="FunCoup" id="A0A132B8P8">
        <property type="interactions" value="1278"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8P8"/>
    <dbReference type="GeneID" id="28825895"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690780"/>
    <dbReference type="InParanoid" id="A0A132B8P8"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="20590" checksum="8DBD5E9890A74CEC" modified="2016-05-11" version="1">MSRLTEYQVIGRHLPSEANPTPKLYRMRIFAPNTVVAKSRFWYFLMKLRKVKKANGEIVSLNVIHEKRPLKVKNFGIWIRYDSRSGTHNMYKEYREMSRTDAVEAMYQDMAARHRSRFRSIHILKVVELEKGDDVKRPYIKQLLTKNLKFPLPHRVSKAAGTKLFAESRPSTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8W5</accession>
    <name>A0A132B8W5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_327215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063200.1">
        <property type="nucleotide sequence ID" value="XM_018206759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8W5"/>
    <dbReference type="STRING" id="149040.A0A132B8W5"/>
    <dbReference type="GeneID" id="28816485"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_327215"/>
    <dbReference type="InParanoid" id="A0A132B8W5"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="579" mass="63951" checksum="35B5E369060DE929" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B906</accession>
    <name>A0A132B906_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_325364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063088.1">
        <property type="nucleotide sequence ID" value="XM_018206741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B906"/>
    <dbReference type="GeneID" id="28816467"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_325364"/>
    <dbReference type="InParanoid" id="A0A132B906"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23456" checksum="55966F650C3B92FD" modified="2016-05-11" version="1">MCARLSLFSSTLLSYQNPLPTPLSSSLSPLLGSLKHGACELISKSIVSSHSSSSLHVKQITHLTSDGEFFKIKKPIVGPGRTPNSTRTDWIPITWSRRGTSLAQKNHVRPPARTHTRGDIRLYMRLASSAESEIGGASYRIQQHHRNASFSYSGGCFLIQRSLDTETLCYLAPILPCHLTLFWGGELRNWGSWRLLAWLLVFRRRIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAG9</accession>
    <name>A0A132BAG9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_724406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063765.1">
        <property type="nucleotide sequence ID" value="XM_018218894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAG9"/>
    <dbReference type="GeneID" id="28828620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724406"/>
    <dbReference type="InParanoid" id="A0A132BAG9"/>
    <dbReference type="OrthoDB" id="3560230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="54"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="207"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="396" mass="44777" checksum="9930BCA2C3BC6349" modified="2016-05-11" version="1">MKIKTFLNLPLTLHPLNFIKLGRNNIYREVLYRSHLLRLSPLPHNFQFDLHHPGLSVSILINNRPLTEYPEPDPSSSRTSSPSQSTNPITTSTTYIASTPNTPFAIRYSLAPPFSALTNTAPLLGVNVFVDGTLVVRETVRKADGERERDRERRFVIRGVKGVDGRGKQVLRSLRFVGRRTCELFLLLFGGRGKGREREANMKLIADENVPAEGDQRLLANAGRIDVEFWRLGEGVVRDWYARSEVLEVGMGARAVHEKALKGEPVYHCVDFVEEKVVERPVVRRRVGKLDQAPIACFTFKYRSEQALKELMIIERTPEPELELELGVSTLNLDGLTPEQRSMAKAYVDGLKSSRIGAGIKREHVEESEEEEGPLKKQKRARKGKEKMVVIDLCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAZ1</accession>
    <name>A0A132BAZ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063945.1">
        <property type="nucleotide sequence ID" value="XM_018220618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAZ1"/>
    <dbReference type="GeneID" id="28830344"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740676"/>
    <dbReference type="InParanoid" id="A0A132BAZ1"/>
    <dbReference type="OrthoDB" id="3565152at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="282" mass="32105" checksum="7441EC0623B3E3DF" modified="2016-05-11" version="1">MTADTPDIQAPSIPSSRFTRRFIELMQPKARTSASPAPASDLQVALVSTSSISDTLAAATLDEDSTVNETENERNSSILSTFTSFINLPVEIRNQIWREYIEDNPRVIRLARTSNPPAIFCQINQKFRAERELYGYVDLKRQTQDGKELTTIFHPEVDLLYLPAARSIQVAHAGLRQADSGIYRDTIMSILGASDALLRIRNIAYPGPLFYSPEAFVLPLPNLETFFIILWESPQRRKGYRWQLSQRFDDRPQVQHLQRLVSADSPNARVLICLNRVWEEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBM9</accession>
    <name>A0A132BBM9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_597820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064187.1">
        <property type="nucleotide sequence ID" value="XM_018209997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBM9"/>
    <dbReference type="STRING" id="149040.A0A132BBM9"/>
    <dbReference type="GeneID" id="28819723"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_597820"/>
    <dbReference type="InParanoid" id="A0A132BBM9"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13142" checksum="EEF427EBD892B313" modified="2016-05-11" version="1">MFSADDVVLSHGSASGHDLVLEELPLPQDFAWGTATAAYQVEGGASQDGKGPSIWDTFSHLEPSRTNGENADVACNHCNLVEDDVELMSSLDVDVYRFSMSWSRIIPLGGRNDPINGKGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBW0</accession>
    <name>A0A132BBW0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_690658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063492.1">
        <property type="nucleotide sequence ID" value="XM_018216139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBW0"/>
    <dbReference type="STRING" id="149040.A0A132BBW0"/>
    <dbReference type="GeneID" id="28825865"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690658"/>
    <dbReference type="InParanoid" id="A0A132BBW0"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="9"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="45321" checksum="336CAAA339E0AFD2" modified="2016-05-11" version="1">MAEADMEKEFQAAIDSGKIKGVIVCATDAESNFVYEKTLGERTLLSGERRPHQLDDVLFLASATKLHATIAALQCVEDGLLSLTDDLSTILPELAAQKIITGFSEDGETPLLEPRTRPITLEMLLSHSSGATYYFLDPMIARWRQKFAPKPETLAKSSVPVEDMFDYPLSFQPGTSWMYGPGLDWAGRVVERVSGKTLGERMHERIFDPLGITDAQFYPVAREDLRARLVDLNPEDPEVYGKAVMGGPNDMNKLGKGDFGGHGLFMTAPDYVKVLHSLLANDGKILKPETVNDMFENHLSPEAAAGHKAAVSEENPFGIFFRVGTAPGSKAGYGLGGHLTLEDVDGWYGERTLTWGGGQTFAWFVDRKNDLCGVGAIQATIPTDPEVAHTLKQTFRHDIYRKRAQWKKEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC58</accession>
    <name>A0A132BC58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_724232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064208.1">
        <property type="nucleotide sequence ID" value="XM_018218880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC58"/>
    <dbReference type="GeneID" id="28828606"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724232"/>
    <dbReference type="InParanoid" id="A0A132BC58"/>
    <dbReference type="OrthoDB" id="3445303at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="189" mass="21689" checksum="C9A91AC881EA8EC8" modified="2016-05-11" version="1">MVFFFLSLRESGSRIEPDILPTSTSTSASLLPKAPPRWQDSEFQDYITNWDTSDKPALFRRVACMLALVLHLPINGISILSYGISFWLFMGIVISVLNLGGVGWALWKLDTMRGERVFYGKVFQRKHFDYVILGLVIVYGFFFGMFLFVRMRASDWAWFFRIGWPCTIAADIVCFISGWVATWRDVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC95</accession>
    <name>A0A132BC95_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_740439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064390.1">
        <property type="nucleotide sequence ID" value="XM_018220586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC95"/>
    <dbReference type="GeneID" id="28830312"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740439"/>
    <dbReference type="InParanoid" id="A0A132BC95"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="32243" checksum="6F3C92AF82E48830" modified="2016-05-11" version="1">MSSLTECYKNTEPHCDMWSQLLKYAQSFERYAPFKQDMAKVNSNSTSNFKKFSHKKTSHLTNHQLRSANPFIDGQNSHSVENGLLEASQAAAAQDFVNFKLHRATVLHYLEPQYLDMMMQRSVFNRYLGDLSDSGAFFCIGHNDPCGSDDLPLAMVYLENYSRAFQRHLDIYTRTRMIRQRRTFESLYSSMPREEAMNIVYDMVEHGSLVDFGVFWSLFRSVCDDMDTQFFEIVSAREGLFLGDVGKYKACSLDAELGSSQKPMRWLDEMLTSDSDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCU0</accession>
    <name>A0A132BCU0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_724090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064019.1">
        <property type="nucleotide sequence ID" value="XM_018218870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCU0"/>
    <dbReference type="GeneID" id="28828596"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724090"/>
    <dbReference type="InParanoid" id="A0A132BCU0"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000010">
        <property type="entry name" value="Putative rhamnogalacturonan acetylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="27138" checksum="22C9C8350FDD1E2B" modified="2016-05-11" version="1">MKSVAIVPTLAVAAFAAPAKDIEKRATPHVYLAGDSTMALGGGGTSTQGWGVYLPYSLKDVTVVNDAVAGRSARSYTDEGRFTTLVNTVASGDWVIIEFGHNDGGSLSPTDNGRSDCVGSGSETCTTAAGVVVQTYVTYLTNAAKALLAKGAKVIISSPTPDNTCESGTCSYTPSRFTAYCKDVVENAGNGASFVDHGQYVANEFNALGATVVNSYYPKDHTHTSPIGANVVAAAFMKGLMCNNDPLATYSKNTTASIAGSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD81</accession>
    <name>A0A132BD81_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_656898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064568.1">
        <property type="nucleotide sequence ID" value="XM_018212410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD81"/>
    <dbReference type="STRING" id="149040.A0A132BD81"/>
    <dbReference type="GeneID" id="28822136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656898"/>
    <dbReference type="InParanoid" id="A0A132BD81"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="66"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="432" mass="48341" checksum="62B78CB43DD3391F" modified="2016-05-11" version="1">MLSTRGQKYREIGYQHGLLDEYNEETNPNGIVDLSSAENFLIHGEVIQFINSHKLDASCCGYGEGYTGTLRLRKAMALHMNEYCNPFEPLTAEHITFAAGVTDLNEVCALLTCDADCGDAILLGKPNYGSFARDMVSRGHISQVFADFGGADQFSSDCVPYYLKAYDAAKEEGINIKALVICNPHNPLGQCYSREALIELMKFCQSKQIHLISDEIYALSTYQRTDRPSEKYVSVFAIDSRQFVDPNLIHVLYGLSKDYGAAGLRLGCLITRNAEFSDAARSLCRFSSPSQISMSLAAALLEDRIFLKSLLESSHSALYKSRKVAEVALEQVGIKYHREGNAGLFLWLDLRPYLPTTVTNGDEWAAEKLLWNRFENIGVQVSLGKRYFAPNPGHFRMVFSNHESVVLEGIRRIKTVCNRSKNKSDWPCQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD95</accession>
    <name>A0A132BD95_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_760226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064755.1">
        <property type="nucleotide sequence ID" value="XM_018221500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD95"/>
    <dbReference type="GeneID" id="28831226"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760226"/>
    <dbReference type="InParanoid" id="A0A132BD95"/>
    <dbReference type="OrthoDB" id="5428901at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="856" mass="93931" checksum="09271AA3EBBA8271" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDK2</accession>
    <name>A0A132BDK2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_787482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064816.1">
        <property type="nucleotide sequence ID" value="XM_018223077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDK2"/>
    <dbReference type="GeneID" id="28832803"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787482"/>
    <dbReference type="InParanoid" id="A0A132BDK2"/>
    <dbReference type="OrthoDB" id="3552781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="14226" checksum="55E5F7DD5B21D5F0" modified="2016-05-11" version="1">MFAPPPPTTPESVDMQLEAQLAQTMAEAAEREEKEKKKERRAAPGRERKLVNLTVTTNSSDAVGRSDRIRRKRPSIETLRRGHQQPSAFCVNAESRAVAIENHVKIPDGANAPNSKGATYVHKELDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDP6</accession>
    <name>A0A132BDP6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_266856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064309.1">
        <property type="nucleotide sequence ID" value="XM_018206322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDP6"/>
    <dbReference type="GeneID" id="28816048"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_266856"/>
    <dbReference type="InParanoid" id="A0A132BDP6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="133" mass="15011" checksum="B2ED6BB1472ED541" modified="2016-05-11" version="1">MIFDPTLQTISCSFSLRSFLPGWPCAYEPSLLGLSLVFFFATQSTIYLRRCRFSCGFDDISVSYQSSSISLTSDELSLIQAHAELHASTRFNDQDHGRGDPIRPVLNPRFTLLPRGMHSLLLSFYQLDHDGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BET5</accession>
    <name>A0A132BET5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064552.1">
        <property type="nucleotide sequence ID" value="XM_018220610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BET5"/>
    <dbReference type="GeneID" id="28830336"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740589"/>
    <dbReference type="InParanoid" id="A0A132BET5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288199" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="11885" checksum="5EC33822662CEB64" modified="2016-05-11" version="1">MRLISLFTVVFFSANCVIATPVQILNGKGLSFADGLPEGYSIGKLRYRATIDGLVVGFEGDSREDIYAQVKAKSPDFQIPYGNATEIKEPTALLESRDPSNLKPREFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRS3</accession>
    <name>A0A194WRS3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_689341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065048.1">
        <property type="nucleotide sequence ID" value="XM_018215890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRS3"/>
    <dbReference type="STRING" id="149040.A0A194WRS3"/>
    <dbReference type="GeneID" id="28825616"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689341"/>
    <dbReference type="InParanoid" id="A0A194WRS3"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="189"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="38338" checksum="B113372644175048" modified="2016-10-05" version="1">MGSITTNEVAGGLISEIRHFSRQLVREWGFMSTEAAGTSYPASAVHALIEISLNEGLMSAELCAPLNLDKSSVSRVVKKLVEAGELEEEFDGGAAGKGDGRVKRLVLSAKGRETVRVVNEYGNHQVASALAKLPTTTSPTTILTGITAYATALRASRLNYSPSTSNPPTITNPPLDLHLAPKPTIQILPGYRPGLVASTLQLHMSFYNAYYALGLEFETNLSAEMAEHAPRLDGLKSQAWVAVSSNNNQTVGSVWIDGNYAAAAETEKKVARLRFFVVADGMQGMGIGRRLIGAAIGFCDEKGFEECLLWTFKGLDAARRLYEKVGFRLVSEEMKGMWGKELLVQCLVRKGGGGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTQ4</accession>
    <name>A0A194WTQ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoA-dependent acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_595294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065686.1">
        <property type="nucleotide sequence ID" value="XM_018209852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTQ4"/>
    <dbReference type="STRING" id="149040.A0A194WTQ4"/>
    <dbReference type="GeneID" id="28819578"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595294"/>
    <dbReference type="InParanoid" id="A0A194WTQ4"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="737" mass="83269" checksum="2E3BBDFBE5A4F45C" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTW9</accession>
    <name>A0A194WTW9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nagb/rpia/CoA transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_674706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065741.1">
        <property type="nucleotide sequence ID" value="XM_018213457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTW9"/>
    <dbReference type="STRING" id="149040.A0A194WTW9"/>
    <dbReference type="GeneID" id="28823183"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674706"/>
    <dbReference type="InParanoid" id="A0A194WTW9"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="56357" checksum="1103ADECA80EADB2" modified="2016-10-05" version="1">MSSNLRKRSVVSSFICTPPNSPSGFTFALFKRSQDVSTYRGKWAVCSGSIDKTDLSPAAAAKREILEETQLSDCDISLLRRGRPFSLIDEALQTEWTIHPFAWQLKEGANQIKFDWEHIEFKFIKPEDLSSYDHVPQLEVGLERVVVSPMTQKALTALRNDHESGAQALALKALDFLLEAARSEELAGIWSSEEYWKELRWRAWHLAKNGRPSMAAAIESSILNALEDIESHVSEDGGGKIATCSLSRLTSIIESVISSKLDSGASNLDPIARSFTDLILPETKGSDKESRTSMNITTISASGTVRTGLLRAIPQLIAQGIAVKLTVLESRPNFEGASFVNTLLDQFQGDSDILNKLKFEIVSDASVANAVKDAHFVVFGGDKVIPNGDVSNKIGSFSLAAIAKTVSPACKVVAMFETNKITGSGFDSEYLAVEENDPDEIINAWPLVLQSDLYMKETLGAQVKVKNEYFEWVPARFVDHYITEKGLWGVEEIAKAAAELEEREKRLFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU18</accession>
    <name>A0A194WU18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_236940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065462.1">
        <property type="nucleotide sequence ID" value="XM_018206069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU18"/>
    <dbReference type="FunCoup" id="A0A194WU18">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WU18"/>
    <dbReference type="GeneID" id="28815795"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_236940"/>
    <dbReference type="InParanoid" id="A0A194WU18"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="416" mass="44476" checksum="8E7D6C30F41B2788" modified="2016-10-05" version="1">MADHPIDTPPRAPSPVHRFGTLAVHAGSPHDPVTGAVIESISLSTTFAQTAVGQPIGKYEYSRSSNPNRDNFETAVAALENAKHALAFSSGSATTAVILQSLAAGSHVISVSDVYGGTHRYFTQVASAHGVKVTFTPEIEVDIRQHITPDTKLVWIETPSNPTLRLVDIRAVATQAHQHGIKVVVDNTFMSPYVQNPLDHGADIVVHSVTKYINGHSDVVMGVAAFNSEEMLKRLSFLQNAIGAIPSPFDCWLAHRGMKTLHLRAREATTNATSVAKALEGSPHVIAVNYPGLNSHPHRAIAIKQHRNGMGGGMLSFRIQGGHAAAERFCQATSLFTLAESLGGVESLVEVPSSMTHAGIPKDQREAVGVYDDLVRMSCGVEDAEDLKADVLQALEKAVVLPKITNGLNGFAHRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU22</accession>
    <name>A0A194WU22_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_625661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065534.1">
        <property type="nucleotide sequence ID" value="XM_018211082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU22"/>
    <dbReference type="GeneID" id="28820808"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_625661"/>
    <dbReference type="InParanoid" id="A0A194WU22"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="35974" checksum="8AFC8DC152F0A567" modified="2016-10-05" version="1">MSSEPLVTHIFTADPSAHVFNGRIYVYPSHDIATPIQDNDNGDQYAMTDYHVLSMDAVGSPVTDHGVVLSLEDVPWAGKQLWAPDAAEKNGKFYLFFPARDTEGVFRIGVAVGDKPEGPFKPEEKPIEGSYSIDPASFVDEDGEAYLYFGGIWGGQLQCWTTGKFDKEAYTNMEAQSGPALLPRVAKLSSDMLSFTSPPTELEILDPVTKKPLDSSDHDRRFFEAAWMHKYNGKYYFSYSTGDTHYLAYAVGDSPVGPFTYGGKILEPVQGWTTHHSIVEHDGRWWLFHHDTSMSGKNHLRCVKVREIFYDKEGKIVLTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU66</accession>
    <name>A0A194WU66_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065507.1">
        <property type="nucleotide sequence ID" value="XM_018215839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU66"/>
    <dbReference type="GeneID" id="28825565"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689076"/>
    <dbReference type="InParanoid" id="A0A194WU66"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="224" mass="25068" checksum="1128330CE9D89230" modified="2016-10-05" version="1">MDITTVLASPQIQDLPEPRLLTTHEASLSLNLSTRLSPLSSRIPPPLTLLHHLYLHLHINPSHAYTRHIEHNPQNHPHRHGTNSTTRKSFHNTKTNYHHLPASYLPEIYSTATPADILRRLPTHAPDHEPPQLRLTRPFIPSPINSPIGFDSNPTQSHLTSPQKPNQPTNQPAAAAAAAEHYAPQLALHTYLGTYASITESQVRPLSQSWESSLPMFRMHYCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUV7</accession>
    <name>A0A194WUV7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_225764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065799.1">
        <property type="nucleotide sequence ID" value="XM_018205988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUV7"/>
    <dbReference type="GeneID" id="28815714"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_225764"/>
    <dbReference type="InParanoid" id="A0A194WUV7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="81"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="20439" checksum="5665A078E9A1117D" modified="2016-10-05" version="1">MSLVALGRTPRTGNADGSVTKSLEVALSDFGSVLTDDERKQLQQIKEVPDASAALVFTAKLGASNMTRRGRSIGARAFSMLQSVQQFSAFVETFVSSHPDVAALVWGSVKLTVLIAANITSYYESLADLFMGLNKLFPQLEEYQLLFPRSSTLQESICTFHASIVQMCKESIRLTRQPCKDKESHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW21</accession>
    <name>A0A194WW21_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_594471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066137.1">
        <property type="nucleotide sequence ID" value="XM_018209806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW21"/>
    <dbReference type="GeneID" id="28819532"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594471"/>
    <dbReference type="InParanoid" id="A0A194WW21"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="231" mass="25438" checksum="0E68E7ADD635A18A" modified="2016-10-05" version="1" fragment="single">MASASPLSPTFYGHIASTQDALLLFEACLSGALNHVARRPHDRERVSLIKSGNVFIYEEHSSGIKRWTDGVPWSPSRILGNFLVYRELERPFPPGEKKRAMKRSKRSPGISKPDSFGPPGNGISNGYNPVPAAASSFETSSTNSLSKETERSLIGSLVDSYGFKEEGLVKKTVSVTVGGVSHHLVSYYTVADVMNNKFTTPSKDPRFQHITPRPDLITKQNFRTPIDEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW55</accession>
    <name>A0A194WW55_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_623960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066172.1">
        <property type="nucleotide sequence ID" value="XM_018211037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW55"/>
    <dbReference type="FunCoup" id="A0A194WW55">
        <property type="interactions" value="1115"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WW55"/>
    <dbReference type="GeneID" id="28820763"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_623960"/>
    <dbReference type="InParanoid" id="A0A194WW55"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="473" mass="52750" checksum="F6BDEAA135910711" modified="2016-10-05" version="1">MADPEPSVQAALAADAPTKQSSKQTVDPYNVAGEIGADGIAKAINYLTLIEEFGTKKILEEDLVRFEKVTGHKPHRFMRRGIVFSHRDLNYILDRHERGEPFFLYTGRGPSSDSMHIGHTVPFEFTKWLQDVFDVPLIIMLTDDEKYIFSEKRTIEEVTSYTWDNAKDIIAVGFDPKKTFMFSDYDYMGGAFYRNVTRISKHVTLNVARAVFGFNDSSCIGKIHFGAVQGATSFASSFPHIFGTDESKTNLIPAIIPCAIDQDPYFRMTRDVAARLHFAKPALIHARFLDALQGPGSKMSASVDSSAIFMKDQPNQIKNKINRYAFSGGQVTEAEQREKGGDAEKDVSYQYLTFFLEDDDELERIRVAYTKGELLTGELKAKCIAELQTYVKGFQERRAAVTDDVVKVFMARKKLEWRGNPNAIVVKKPEGESAGGEAAGEGTPKMTKNQEKKLAKLKAIEEKKAAAKAGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXN2</accession>
    <name>A0A194WXN2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EBDP4, emopamil-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_688090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066702.1">
        <property type="nucleotide sequence ID" value="XM_018215637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXN2"/>
    <dbReference type="STRING" id="149040.A0A194WXN2"/>
    <dbReference type="GeneID" id="28825363"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688090"/>
    <dbReference type="InParanoid" id="A0A194WXN2"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="62"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="255" mass="28878" checksum="3AEDE0C8EB975C82" modified="2016-10-05" version="1">MSHEGTNIPSHPYYPLDIKLINYLANDKDPLFLISVFATGCIIILTTTILLIRKTNPTLPTSDFFTVLWFVMCMFPLPSHFQVHLTNDQGGFIHLLIEGHYTLNFLTLHQSPTVLSQMWKVYSLSDSRYLTQNAFIFCMESITAFIFGPLSFLLAFLILKNHPLRNALQTLVSTGQLYGDVLYYATNGFDEYVHGLTYSRPERRVLWGLYVGLNAVWIVVPPILVYSSMRASGKAFAALAKMERVLARNGSAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYD8</accession>
    <name>A0A194WYD8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_709465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067338.1">
        <property type="nucleotide sequence ID" value="XM_018217761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYD8"/>
    <dbReference type="GeneID" id="28827487"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709465"/>
    <dbReference type="InParanoid" id="A0A194WYD8"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="13"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="484" mass="55163" checksum="B727F30D72F6C099" modified="2016-10-05" version="1">MAPQRGPTKRTEKRLVLCFDGTSNRFKGNETDTNIVKIYEMLDRNIPDQFHYYQPGIGSYVEGQMSNSSGGNIFTRARGLISTSVDSAFGTSFVQHVIAGYRFLMRYWNEGDKIYIFGFSRGAYTARFLAEMLCNIGLLSCGNEEMIRFAWSTFSDFQTNRSKDPSFKAFMEKFKETFCRGAVKPHFLGLFDCVNSVGQFDIPLFRTSLPYMPMSPAKHIRHAIAIHERRLRFKSAHFLFDLKAPIKDDIKEVYFAGNHGDVGGGWSCNGEKYLLSDITLRWMVQEVLDLPDTVSLSSNLAYRNLNATKPIREGPYHFRDLVHDCLPFGGGSGWFEVLAWWIVGKWTFLALSKQLSTNNNQEWVPFSYGYISDGKWVSRQLPPNLGSRRDIPVGADIHPSVMMMNRAGVLPEDQMPRMGGEELYNAQKPLSFLRPLIKVPKTKKPKPDEINALRSGESLDSEESGNRWSFDRMMEIGAKTWDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYV8</accession>
    <name>A0A194WYV8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_192736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067132.1">
        <property type="nucleotide sequence ID" value="XM_018205718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYV8"/>
    <dbReference type="GeneID" id="28815444"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_192736"/>
    <dbReference type="InParanoid" id="A0A194WYV8"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="317" mass="34243" checksum="AA3CD488509EEABD" modified="2016-10-05" version="1">MDPVIGEPFQEHEKRYMLTEALRASTIPLERLYIMLQEANGPPAWDDMVLPRGRTLKQCKAAFESLRPALPPPLPPHPVHAYPAPTQPFQIPPKRKSESAILGPPYMQAEPPAKRRQSGMEPMVGARDIRPKPPNGGSPISMSSTPPTAPQKRRGRPPKAEVDRRNRDAMQRGEVFPAQFLPPTTEEFATSPYTPIAPTPPVLAPGPPTPQGYIEQTPPDTQAEDSPGRKKRPKAPPKPKAAPPRQPGEGSFSVNPQLPIVREPHVHPPVPNIAAITELEQTGPSPQSAPSVMPSPVSATIEAATSAESQPSAQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ26</accession>
    <name>A0A194WZ26_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sphingoid long-chain base transporter RSB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_622860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067197.1">
        <property type="nucleotide sequence ID" value="XM_018210990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ26"/>
    <dbReference type="FunCoup" id="A0A194WZ26">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="28820716"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622860"/>
    <dbReference type="InParanoid" id="A0A194WZ26"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF7">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="35592" checksum="2F111BA3534487A7" modified="2016-10-05" version="1">MSTFSSLLDVRATPNQFENCTFETCSLSSSFWYYRPSLVANSIFLSLFALSLLAFILTYLLTRRFGIFTVALACCCTLEIIGYLGRIISYSNPWHETGFLLQIVCLTIAPSFMAGGIYLCLRNIVEVFGSEKSRIRPESYTRIFIPCDVISLILQALGGAMASMASHQGHSSALGDHIMVAGLAFQVSTLTLFMAVCIDFAVRTSKHPDDNRDDTKLLSVRSTKRFSQFIFSLAIATICIFIRSIYRVAELSESWTGHLIRQQWLFVGLEGVMIVVAFAVLNISHPAFCFDARSAASTGAEISDEFTSGDQAKEMDSENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X039</accession>
    <name>A0A194X039_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_591526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067592.1">
        <property type="nucleotide sequence ID" value="XM_018209658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X039"/>
    <dbReference type="FunCoup" id="A0A194X039">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X039"/>
    <dbReference type="GeneID" id="28819384"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591526"/>
    <dbReference type="InParanoid" id="A0A194X039"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="395" mass="45493" checksum="35422CEF9BD3A1E1" modified="2016-10-05" version="1">MRRQVEESDLPDFLHNSPFLPISDGVAYSYPKAVPQPKPTLRQLLKSKPVRASIATFFGLLIFLYLRSRFRSAHVLNRLTGPSCYFTTPQIPNESYLTQDVDWSQFAYALYATNVEYLCNAVMLFESLHRLGTRAERLLMYPETYSLLDTSGSVETTLLLKARDEYSVKLQPVKVQHENTAYYYGPNWADSYTKLLAFNQTQYTRLIVLDSDSTLLSPMDALFFLPTTPAAMPRAYWLTKPLLSSHIMVLTPSPSSFALVQTAIKKARYGVYDMEIMNSLFGSACLTIPHRTYALLSGEYRSEDHEPFLNLEVELDDGREKEEWNPDVVINEAKLVHFSDHPLGKPWVVSEEEIRKVAPGCDKISGWEEECRTRDVWLDLYEDFRRRRKVSFSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X182</accession>
    <name>A0A194X182_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cysteine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_622569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067977.1">
        <property type="nucleotide sequence ID" value="XM_018210980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X182"/>
    <dbReference type="STRING" id="149040.A0A194X182"/>
    <dbReference type="GeneID" id="28820706"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622569"/>
    <dbReference type="InParanoid" id="A0A194X182"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="383"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="58413" checksum="ED97B4957CC4F7CB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2B1</accession>
    <name>A0A194X2B1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_671676</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
            <location evidence="1 14">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 14"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068668.1">
        <property type="nucleotide sequence ID" value="XM_018213232.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194X2B1">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X2B1"/>
    <dbReference type="GeneID" id="28822958"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671676"/>
    <dbReference type="InParanoid" id="A0A194X2B1"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052841">
        <property type="term" value="F:inositol bisdiphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052724">
        <property type="term" value="F:inositol hexakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000830">
        <property type="term" value="F:inositol hexakisphosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000831">
        <property type="term" value="F:inositol hexakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="18">
        <location>
            <begin position="311"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="17">
        <location>
            <begin position="537"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="700"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="907"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1230"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1532"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="660"/>
            <end position="672"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="700"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="760"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="907"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1232"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1561" mass="172481" checksum="CEF23F4CE7947830" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X393</accession>
    <name>A0A194X393_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069013.1">
        <property type="nucleotide sequence ID" value="XM_018222718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X393"/>
    <dbReference type="GeneID" id="28832444"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783756"/>
    <dbReference type="InParanoid" id="A0A194X393"/>
    <dbReference type="OrthoDB" id="3528648at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="72"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="340" mass="39136" checksum="296944A9D7DCAAE1" modified="2016-10-05" version="1">MEASKPSLEALRMREVEKIAATIAAEAHQFGLEPRGVSEDSLRAVLESTQSLLNKLKTWTSSSSTSIELGDFHYFQNLPDELKVLIWKFSLPSARILPVQHHIDHDRYAKDRSDQELEPGEPAALELFLEYQKDPSKYMTTVLRHEQSSILWVCRQSREEALKVFSLRLDTTKTTCGFRIDPGFDTLYFQYSNRRNHDMHFKFETGQLWQSIALSAIQHLAFDTKRLTNILDVELGNPFRRLGALKDITVVCHSTGCRLHDRELAYRSIHLEVLVENSPPFPVIGSYEQIQRLRDRFSVCRATKPDWHVPSIILKTARMEGSSKICCEMTWKELQAVIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3F1</accession>
    <name>A0A194X3F1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069051.1">
        <property type="nucleotide sequence ID" value="XM_018213204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3F1"/>
    <dbReference type="GeneID" id="28822930"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671120"/>
    <dbReference type="InParanoid" id="A0A194X3F1"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="476" mass="54157" checksum="A15478B5E56C6913" modified="2016-10-05" version="1">MEEVQQAVLSAKRLYDTRSKHADAKRWLRKFSKGIMYYAVILDTLSQHHPEYVSLAWGAMKFIFIGVINHEQLVVELSKALCSMADALPSAQLKNVLYPTEQMKQAVAVLYSHILEILQRAAEWYRGGKIKHLLGSIARPWSLHFSDLVEDLSIAAKKVDELAIGASMAEQRDMHLEQQELRLEQRKTHALLEELKRITEEYQKLSLVAHLNTNQRVCDMQFSQIMTFMATSTECLPSPEVSRKQYQARRNSRQFKKGYGSLKNPVCTRTLQSWADTKHSSTINVCGSFVTRHEAQDFAVDAIDFIAQSQAPLVWILNIHEGRANSDIMLSDVLKALILQILKMNHTMLTERSLSLSAARFQSATTDAEWIALLGTVLEGLPYVYMIIDTEVVGNQYAKWSETFNMLFDELRSRNIGNIIKVALVWYRQKPADLAGVDKTIKIRASAPSGRRPMAVSNWRSRKGPQARLRGLKLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3U5</accession>
    <name>A0A194X3U5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_720313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069213.1">
        <property type="nucleotide sequence ID" value="XM_018218558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3U5"/>
    <dbReference type="GeneID" id="28828284"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720313"/>
    <dbReference type="InParanoid" id="A0A194X3U5"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267813" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="408"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="506" mass="56362" checksum="7AD99444335C0025" modified="2016-10-05" version="1">MASAASLVIFIWLMPFVASKEFSNPNITRTITLSPPSSPAPGRQIVDAAYQSFSIEFSYMADYGGNNSNPNLFSKQVVQNLHDISGAYPIFRIGGSTQNSAVYYPNQSVAIIDPFSSVASDQPSKSMLGPAWFESFQQFPEGTQYIYGLNFFNPVNETLFNVGNGLDQCVLEAYAAHTALGDSLYAFEIGNEVDGWPGGSRRPSNWTIQSYVTQWNQYATAISYNLTGEGAMRLFQGCAFEAPRHIGNRTFWNVQNAELDGMRSNMAKTVSDHEASPTIETTLFNRTNMLSRVWYHDYLGNITAQSGIEYVIGETNSISCQGAFNISDVMASAVWAVDYTMYLSSLRVSRVHFHMGTRYRYSPWQPIYYNDTEPHVKPIYYGNLFNAAVFAGGNKQIEVLLNETNFGAYAVYNSRILESIVAVNLNMWNWTFDLIRRPYTALVLPKHWEKATISRLTSPGVDIAENIAFAGQYVNENAQIVGKKTYDHVVSGKVLVGAGEAVLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4C9</accession>
    <name>A0A194X4C9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_736090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069385.1">
        <property type="nucleotide sequence ID" value="XM_018220085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4C9"/>
    <dbReference type="GeneID" id="28829811"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736090"/>
    <dbReference type="InParanoid" id="A0A194X4C9"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31210" checksum="3DC56DA156428A7C" modified="2016-10-05" version="1">MPNFTVMSVSSSARDRRGKPRLGARGIRKVKTGCKTCKIRRKKCDEIRPACSQCSDTGRRCDFSGGVLNHLPQTSDIPLARKPEMSFSLRPSLPCHMRDLTYAEASHLDYFRLVCAKSFALSLDATLWENLLLQNVHLEPSIYHAALTAAALSRHQYCPMQAWYDRGKTNSPIEFAIVHYNLAIRIVNERLGHSAGSSELAVLASIIFAHVEAFQNFRPGKRDSNLISAHLNGGLAIVHSLKSTSQNIDHLEAALTHMQTQMEQFEQYSARYQHSSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4M1</accession>
    <name>A0A194X4M1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_104003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069480.1">
        <property type="nucleotide sequence ID" value="XM_018205030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4M1"/>
    <dbReference type="GeneID" id="28814756"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_104003"/>
    <dbReference type="InParanoid" id="A0A194X4M1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="72" mass="8303" checksum="A7655EFD6354624B" modified="2016-10-05" version="1">MDGRFSNSPGSELGCFGLPIWPDVASPLVTKPRRAFFDFWIVSGRNFFFTSREIYRIFVVVVDETEEVEHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6K4</accession>
    <name>A0A194X6K4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_686187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069787.1">
        <property type="nucleotide sequence ID" value="XM_018215228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6K4"/>
    <dbReference type="GeneID" id="28824954"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686187"/>
    <dbReference type="InParanoid" id="A0A194X6K4"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF32">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G04120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="33272" checksum="02FCF152768E8B7E" modified="2016-10-05" version="1">MTSTPSAHLTCLCGAISEPGTLLKDDRFPTSASICHCNSCRRTSGSLGASFPPLKSPPPEATLSRLTAYHSSDIITRYFCSKCGCHCFIFHHPRKKWYCLGGVVEPSPSPEAHNVSGPKNTIQVSLHEYVSDTLDGGLAPLFHNLGGRFIPIYTAAPGSAEIAYDTTLSSLKESVNSTPPPAVNSCLPAKCHCGGVSLLIKRANYESSTAAESARYIPSDPTKWLSYFCTCRSCRLSFGVSLTPWTLVLPAHVFNASGVVEGSSKAELVPVVFDRQAASPDANPGLTLKHYWSSPDVCRTFCGKCGASVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X715</accession>
    <name>A0A194X715_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070234.1">
        <property type="nucleotide sequence ID" value="XM_018215148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X715"/>
    <dbReference type="GeneID" id="28824874"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685780"/>
    <dbReference type="InParanoid" id="A0A194X715"/>
    <dbReference type="OrthoDB" id="5399485at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="450" mass="49934" checksum="CCCE1EDC2448E416" modified="2016-10-05" version="1">MRGLVWNTSSAYARLGLRILFNLLLLSFGLIGDQCCKERTELQILLKQPLDLTHYTGWLHGSNAAWAMHKMKRLPAGWLGVVMILTGLMWTAADLAVSGLVVSIDVRDRCAFNTSGLYEVMYNESFSNYIVPYTVGNLFNLVTRAQVTSQANGGLGGIYEKVNGDPTFRADPEDILGQWNCHDVGDDQQYPAHDNITTVLEDLGSKNILFDVQLACSDDYPDNTYGHLVAWSSPRQDFQSTDPWDVRASIDTTANNKEPINMKSFLCSMNASSVEWVLGRTNPATTLKNWCDQLKGLMYENTLTVPPVANPAAVLESTLDAIIMISGASQSGPNITTSPIKDPTQGCLIPKASITWLVVLLLIVVILGTAGMLGYWLFLLRSVRKLRSWRLPSERGEVPNGLLSWMVQAVNDTGMTVSSAELNRWYLVPRGDGRSVRIAREVIRCWQRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8B9</accession>
    <name>A0A194X8B9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_586538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070771.1">
        <property type="nucleotide sequence ID" value="XM_018209373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8B9"/>
    <dbReference type="FunCoup" id="A0A194X8B9">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="GeneID" id="28819099"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586538"/>
    <dbReference type="InParanoid" id="A0A194X8B9"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="525" mass="57961" checksum="9E157CA4E2249B4B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X911</accession>
    <name>A0A194X911_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_749500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071011.1">
        <property type="nucleotide sequence ID" value="XM_018221174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X911"/>
    <dbReference type="GeneID" id="28830900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_749500"/>
    <dbReference type="InParanoid" id="A0A194X911"/>
    <dbReference type="OrthoDB" id="5091156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11191" checksum="D9CF605E730F76A4" modified="2016-10-05" version="1">MAVAGLRYLAAYEVVICIECQTCLLPGRSSQERHLRQPPHSSRGPQLQALLDLLVTYQLQAPNQVALPFPPSPAIEGLRYYDAFACSLCTTSHLTRSRHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9P9</accession>
    <name>A0A194X9P9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_647120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070852.1">
        <property type="nucleotide sequence ID" value="XM_018211942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9P9"/>
    <dbReference type="FunCoup" id="A0A194X9P9">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="GeneID" id="28821668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647120"/>
    <dbReference type="InParanoid" id="A0A194X9P9"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="594" mass="65596" checksum="C9D23C93E53F8252" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAJ2</accession>
    <name>A0A194XAJ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_584985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071519.1">
        <property type="nucleotide sequence ID" value="XM_018209299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAJ2"/>
    <dbReference type="STRING" id="149040.A0A194XAJ2"/>
    <dbReference type="GeneID" id="28819025"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584985"/>
    <dbReference type="InParanoid" id="A0A194XAJ2"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="90" mass="10628" checksum="7BED65F724D135E7" modified="2016-10-05" version="1" fragment="single">RVRILNCWRPLYNLADERPLAFCNLYTVADSDLRAADRASREYVGEIYYMQYSENQKWYWISRQTPDEILLFVNYDSDPKDGGPNGEIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAK6</accession>
    <name>A0A194XAK6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_782382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071558.1">
        <property type="nucleotide sequence ID" value="XM_018222575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAK6"/>
    <dbReference type="STRING" id="149040.A0A194XAK6"/>
    <dbReference type="GeneID" id="28832301"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782382"/>
    <dbReference type="InParanoid" id="A0A194XAK6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="46730" checksum="0CD416F8A78FBF4A" modified="2016-10-05" version="1">MSPPKTCRVIGGGIFGLESALAVATTGMFEKVILFDFPSSSAGSSGSSRILRDGYANPIFAKWAARAMERWETTEYKIFMRKCTRFLIYTSDRINILQGIDNTRKEQGKEPCKRVTAKEVEEAFGSRALGKLFGEGATYIHSPEDCVLDWQQYVDSRRESATRNVEFIQEQVVDLEIDDDKVMQIVTNANVYEVTSEDITVVATGGWTSANLDLWGVPKLPESHQPETVVIMSFEIELTQEALTKMKDNPIISPVGLFEITPLVANKIKVTWVNHRFLEKGSGLLSNPKMLEGTAIMQVAVYHIRKWLREILPDLGIVDLRGDAQIDSMSKAGMPVIAMHPEMPRVCLVMNGGLTSAKLAPLIGELTVNAIFGKPEPDFSLQERDTNIHTQPALTTCATFEEMEQHAKAELRDIRQEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB69</accession>
    <name>A0A194XB69_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_746956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071768.1">
        <property type="nucleotide sequence ID" value="XM_018221108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB69"/>
    <dbReference type="GeneID" id="28830834"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746956"/>
    <dbReference type="InParanoid" id="A0A194XB69"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="95"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="35290" checksum="BDB3E84768BBD36F" modified="2016-10-05" version="1">MKIIDPSPSAQARRQAERRLKQEYLLDQKIIALRKELVEVLGIQTPLEQILPPQLKTQDKHESVMFLRLMIMDALQNKLVHMQSLKLIPPPSPTFTCFSNLPPELRLKIWDYTLENHCHERIHSVDVSEKDRNEFMAGDYDAENPQHLIKVISNQLIHPTLHVCHESRMQYLYRTGASFSSHLATYINFNTDVIYIPNNDFAAEIFRKLVQDSRRCPNQLQRIAMPAQLYCNLPMDDGERLETVHFDMRDAMPAWRETLIVFADDVFMNLWSETKWKIVELTAKQKRLRVREAMQGNMSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBR0</accession>
    <name>A0A194XBR0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_707093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071953.1">
        <property type="nucleotide sequence ID" value="XM_018217574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBR0"/>
    <dbReference type="GeneID" id="28827300"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707093"/>
    <dbReference type="InParanoid" id="A0A194XBR0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="648" mass="73205" checksum="27BE79267C1741EE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCA6</accession>
    <name>A0A194XCA6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_583894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072146.1">
        <property type="nucleotide sequence ID" value="XM_018209237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCA6"/>
    <dbReference type="GeneID" id="28818963"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583894"/>
    <dbReference type="InParanoid" id="A0A194XCA6"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF1">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="48280" checksum="9D6E36E79A2993CE" modified="2016-10-05" version="1">MDFGNKRIAVIGGGLGGMAFVNAALYAGLENIQLYEQAPEFTEVGAGVNITKNANIILDAYGLKDAMRWKSSHDPPCYMEYRNFKTGEVFGQIDEFGQPSSRQIHRAHLLEVMKERVPESILNTGKRLTSIEWDKTNKEYAISFQDATAATADIIIGCDGIKSAVRAHLGFADHPNYSGQMVYRGYVEYSDLSPTAAQELRKTVVYRGKQRHILTLPIGNGESKTARVGVIGFMTEPLEEWVSESWMAKAPVDKLAEHVEGWAPTCQEIIEGLRKNAERGPDKGLILKQALYVRDPIPKWYQIEEGETGSGIILLGDSAHSTLPHQGQGTCMAIESGVALATVLKNWKGEDLESAFAFYQGLRKPRTDKVTKTSYEAGKLASADVPEGTSQVFNPDALRERMKWIMNYDVLKDVYEQGAPYFEDSGNGEVQIQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCU2</accession>
    <name>A0A194XCU2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072334.1">
        <property type="nucleotide sequence ID" value="XM_018219717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCU2"/>
    <dbReference type="GeneID" id="28829443"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732681"/>
    <dbReference type="InParanoid" id="A0A194XCU2"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08243">
        <property type="entry name" value="quinone_oxidoreductase_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="35445" checksum="F1E805050B17EA9D" modified="2016-10-05" version="1">MSHSTMKAAVIYEAGGPSALKLEQKPTPTPQPGNVLIKIHAFGLNRSELFTRQGHSPNVKFPRVLGIECVGTVASCPGNEFKEGDVVATCMGGLGREFDGGYAEYSSVPVKNVQVIKGGVEGLSDGEGHHGWEVLGACPEMLQTSWGSLFKSLRVKSGERFLVRGGTTSVGLAAASIAKNYGAFVASSTRRKDREQMLRDAGADEVVIDDGSVSKSIEEKYDKVLELIGTTTLEDSLQCVKEGGSVCMVGMVGGKWEMDKFSPMGSIPTAVNLTTYAGGPEDFMATPLNELVGQIRDGKLKIKIGKVFKLDEIVEAHKVMEENSAGGKIVVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCZ3</accession>
    <name>A0A194XCZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072400.1">
        <property type="nucleotide sequence ID" value="XM_018214792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCZ3"/>
    <dbReference type="GeneID" id="28824518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683989"/>
    <dbReference type="InParanoid" id="A0A194XCZ3"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="31788" checksum="7CA42341648684CB" modified="2016-10-05" version="1">MSCPDCFRGGVHEGDPVGSTTTIHGLPVYVSNPPEGATPKGIVVFIPDAFGWEFGNNRLLADKYAKRAGVVVYLPDFMAGSAMPLSGLDLLDKIMTPTSWLNTILYKPFYILQAMTQAIPFIFKNRLSVTKPRVSSFIQALRTSPPPFPTTNLKIGAAGFCWGGKHTMLLAQDPPSSRVSPYSSTSTSLPLSPLIDCAFTAHPSMISVPADIEQITVPTSVAVGDVDMAMGKKDILTMKEILEVKKKGDHEVVLLDGAKHGFAVRTMDDKHQWECAAKAETQAVQWFGRWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDD7</accession>
    <name>A0A194XDD7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AIP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_41485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072543.1">
        <property type="nucleotide sequence ID" value="XM_018207358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDD7"/>
    <dbReference type="FunCoup" id="A0A194XDD7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDD7"/>
    <dbReference type="GeneID" id="28817084"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_41485"/>
    <dbReference type="InParanoid" id="A0A194XDD7"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="516"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18188.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110237" checksum="097DC2CE1CB7A4B2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDG1</accession>
    <name>A0A194XDG1_MOLSC</name>
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        <submittedName>
            <fullName evidence="15">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="15" type="ORF">LY89DRAFT_644206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
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        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
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    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
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            <position position="449"/>
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        </ligand>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="506" mass="58133" checksum="8D95B28F5DDCB61C" modified="2016-10-05" version="1">MAIFTSLNTVLFAIFAFIFYTIGLVLYRLFLSPTSKFPGSKLAASTLWYEFYYEAILPGQFTFKIREWHEKYGPIIRINPYEIHVDDPGFYHTVFSNSGIRDKHAFYTGQFGNPNTAFGAVSHDTHRMRRQALNPLFSKASVVRLTPVISTIIEKLCRRIDEVKGTDRPLNMRLVYMCFTTDVVTRYALNRSWDLLDSADFSPLWKEMVRSTGEMTKWTKQFPWLFGVVKTLPEWVIKGLKPDLGLVLDMQTKINTQILQIMQEKEPKPAISDEQEQLPRTIFHALWNNPNIPSEEKSIDHLGQTGQDVIGAGGESTGAALAVTTFYLLNTPRALKKLKTELEEAMPDKYGQWALSLAEGLPYLTGVVLEGLRLFYGVSSRLSRIAPTTPLKYQNWEIPANTPIGLTNLLLHHHPSIFPDSHSFLPERWLDNRPLEHYLFSFSKGSRQCVGINLAKAEIFLTLATLFRRFEMELFDTTFERDVDVRRDMFLPQPSRESRGIRVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDN1</accession>
    <name>A0A194XDN1_MOLSC</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_732971</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Serine threonine-protein kinase mak"/>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="509"/>
        </location>
    </feature>
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        <location>
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            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="800" mass="87592" checksum="849626AAB1ADB2B8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEG4</accession>
    <name>A0A194XEG4_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Putative UPF0157 protein YqkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_774406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072935.1">
        <property type="nucleotide sequence ID" value="XM_018221963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEG4"/>
    <dbReference type="GeneID" id="28831689"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_774406"/>
    <dbReference type="InParanoid" id="A0A194XEG4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24034" checksum="00260D57224BEA9C" modified="2016-10-05" version="1">MERPWWEPLPIALEPHNPSWATEFNTAAQMLRTLLSGLPITSIEHIGSTAIPDLLAKPILDIDIVISGPDFPAILQRMKEGGYTHLGECHLPGRHAFWQPGANAKTGEPTRWVEVEGVGSVRERRRNTYVCFERSLSLRNHRDLKRVLMEDEELRKEYGERKSYLVHTLLIDDVEEYCFGKNAVVQKILKKAGWSDEDLAVVCKTGWYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEM2</accession>
    <name>A0A194XEM2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_706335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072951.1">
        <property type="nucleotide sequence ID" value="XM_018217515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEM2"/>
    <dbReference type="STRING" id="149040.A0A194XEM2"/>
    <dbReference type="GeneID" id="28827241"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706335"/>
    <dbReference type="InParanoid" id="A0A194XEM2"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="72"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="682"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="769" mass="86529" checksum="F7B6301CFBE6F93A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF08</accession>
    <name>A0A194XF08_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutamate-1-semialdehyde 2,1-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_780778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073130.1">
        <property type="nucleotide sequence ID" value="XM_018222416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF08"/>
    <dbReference type="STRING" id="149040.A0A194XF08"/>
    <dbReference type="GeneID" id="28832142"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780778"/>
    <dbReference type="InParanoid" id="A0A194XF08"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="50116" checksum="86601CB546E93F20" modified="2016-10-05" version="1">MADCSTFVKADTPGSAPQTSKIDAQSILEEFRHRYTERNALSLAQFKQDAIYMPGANTRSVLHALPFPMVIARGQATTVWSVDGHSYIDFLSEYSAGLYGHSCERIWTAVNSAMKKGWNLGGKNEYEGKLAQMLVERFGNSMDMIRFCNSGTEANLMAIGTAIAYTGKQKILCFLGGYHGSSISFPEASPCYTMNPKYEFVLAPYNDILATDAVVEALPPNSLAAIIVEGMQGAGGCIPGRPDFMQHLQKLASEHGALFILDEVMTSRLAYGGLQSTLGIKPDITTLGKWPGGGFSFGAFGGRHAVMEMLDPSAKKLVHSGTFNNNTISMAGGIEGCNIFDREAVKSLNDLGDTLRQRIADVLKQRLGHRNTSDRNEQANGAVASASKIYISGVGSLMNVTFAGANKDILQAIFYHYMLEQGLYVATRGYVALNLETKVEHLDIFVRAIEKFVSDYQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF65</accession>
    <name>A0A194XF65_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_506010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073190.1">
        <property type="nucleotide sequence ID" value="XM_018208019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF65"/>
    <dbReference type="GeneID" id="28817745"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_506010"/>
    <dbReference type="InParanoid" id="A0A194XF65"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="14535" checksum="E108EE357457C30D" modified="2016-10-05" version="1">MGIAGPTRHTPPSCLVSNGCQSGCVNASEFESSSSSSLTTLSSTSSSTVSLHTSSTLTSSTTHLSSTSTTAKPTSTSTSDSHHLSKGAKAGAIAGGVIGGIAFIIILLLLWRCWWGWRNKRSVAYHQGANTSGIARVRHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFJ4</accession>
    <name>A0A194XFJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_717460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073320.1">
        <property type="nucleotide sequence ID" value="XM_018218350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFJ4"/>
    <dbReference type="GeneID" id="28828076"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717460"/>
    <dbReference type="InParanoid" id="A0A194XFJ4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="116" mass="13015" checksum="3A5983776091D4B2" modified="2016-10-05" version="1" fragment="single">YSSVNNSSPIQTGNGLPWGGIGGGIGSLIICCIFGYCVAKACGGGRRSGSYPSSSGHSRRDNTSNGVDDDREWRRQQADDLFRQTREDEDRRRREQDAQDARDRQDEINRQNQQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFL3</accession>
    <name>A0A194XFL3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_667644</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072917.1">
        <property type="nucleotide sequence ID" value="XM_018212989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFL3"/>
    <dbReference type="FunCoup" id="A0A194XFL3">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFL3"/>
    <dbReference type="GeneID" id="28822715"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667644"/>
    <dbReference type="InParanoid" id="A0A194XFL3"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="13"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ18562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="494" mass="55799" checksum="72DBE58B1BD06522" modified="2016-10-05" version="1">MDPPLLTEINVISLNCWGLKYISKFRQERMLEIGKRIAAADPAPQIVGLQECWTQHDYKAIRAETKHILPYGKFYYSGIFGGGLAILSKWPIEESNMFRYPLNGRPTAFFRGDWYVGKGVASARIRYGSGEKDVIEVFTTHLHAPYEREPHDSYICHRTAQAWEIAKLMRGAAERGHLVLGLGDFNMIPQSLAHRLISTHSPVKDVWLLLHPDSSVGAAVDPVEKARRRPIPTADINIHENGATCDSVLNTWRWNKGQQKRLGPNKPAIDVPMDRIDPRAKRLDYIFASTGFDASRPDRGGWIIQDVKVGMLMRHPELQCSLSDHFSVEAKLVHSRALQTDTDKDEDIAVADGVYLQSPATSEFRRSYHSQFRRASNTHLPVQTYDEILAMVHKYNGRERKQRRWRLAHFVGQVVISIGCLIAVWWSPRNFVAFLLMLLSTLGLGAGVIDGLIGGLFVGSEIRALKEFEWEISNARMAAGGEPFAMSEEGIKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG75</accession>
    <name>A0A194XG75_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_780155</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073501.1">
        <property type="nucleotide sequence ID" value="XM_018222359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG75"/>
    <dbReference type="FunCoup" id="A0A194XG75">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XG75"/>
    <dbReference type="GeneID" id="28832085"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780155"/>
    <dbReference type="InParanoid" id="A0A194XG75"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="90"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ19146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="397" mass="43438" checksum="513F6AC9AA27D307" modified="2016-10-05" version="1">MRGHRPQALTVSLRGLLQESKPQHVLRRYGTVSSVSAQSAAPPSIFSNALDANAPRHNWTREEIKEIYDTPLMNLAFAAGTVHRKFHNPASIQMCTLMNIKTGGCSEDCSYCAQSSRYQTGLKATKMVTVDSVLSAARIAKDNGSTRFCMGAAWRDMRGRKTNLRNIKEMVNGVREMGMEVCVTLGMIDLEQAKELKDAGLTAYNHNVDTSREHYPSVISTRTYDERLQTIANVREAGLNVCTGGILGLGEKPSDHIGLIHTVATLPSHPESFPVNTLVPIKGTPMGDNAPSPFDATLRTIATARMVMPRTIIRLAAGRTTLSEEQQVLCFMAGANAVFTGEKMLTTACNGWDEDRVIFEKWGLRPMESFEVEALRELVSSSAPPPIEEKPVTTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGI2</accession>
    <name>A0A194XGI2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_487084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207857.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A194XGI2"/>
    <dbReference type="GeneID" id="28817583"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_487084"/>
    <dbReference type="InParanoid" id="A0A194XGI2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="79" mass="8766" checksum="EBEC105FB670FAB1" modified="2016-10-05" version="1">MLHLSNVFRKALRQARRTTEVLFSSKRLESAEAEIKSNIVICLIATFQVWTTPVAPTDCGTTHGKIISLHHESGVCKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGR5</accession>
    <name>A0A194XGR5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073317.1">
        <property type="nucleotide sequence ID" value="XM_018214760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGR5"/>
    <dbReference type="STRING" id="149040.A0A194XGR5"/>
    <dbReference type="GeneID" id="28824486"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683786"/>
    <dbReference type="InParanoid" id="A0A194XGR5"/>
    <dbReference type="OrthoDB" id="4630416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="453" mass="51473" checksum="79D82FBF3BE4A6D3" modified="2016-10-05" version="1">MDEAKHDFKSSHGKFYAMPGRVERVEGSSLQAMFLPKLQPEGRRLINACYRDQFVRGQLKHYGVEVDENKMSGNGALLLKEVLQAGKCAKVPDHIIAVREQLHARWLSRQTPQQLSRSPEFVMDKYFLSFGHPDRTKTTAVVGIPLDRNSSYCWADQMREAASKVADLYHETGFGPETQTIFMGWDPVAVRKAAESHAAKEAKPLRAKKDEREYKRKALHSEYMDTLKLRKASENPETFSPVGSYMVDCKEVEKGFLVQPTDLSIDICETKEPGMFKACFDFGVLVGVMIISVDKNALEQYISRLDRESESDGNDNREYDDDDDDDDEDEYAIDSDRKSTIPAKRKAETLRGRGRPPKKPKTGVAQPRVYQIRLKCRETEGMIHATAERGSIRFKDDIFSGFIGRANLPGVDDGVRFSARKISDTPARRRAGEGSWADYSERAYGYAYVNRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGV0</accession>
    <name>A0A194XGV0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MAK1-like monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_775279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073352.1">
        <property type="nucleotide sequence ID" value="XM_018221988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGV0"/>
    <dbReference type="GeneID" id="28831714"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_775279"/>
    <dbReference type="InParanoid" id="A0A194XGV0"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000331">
        <property type="entry name" value="FAD/NAD(P)-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="133"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ18997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="47775" checksum="49DBF599358D343C" modified="2016-10-05" version="1">MAVTITPEDAPAQPTGINVIVVGAGFGGLTAAIECHRQGHTVSIYESFPELKVLGDIISFGPNAGRIFYRWSHGKIAAKMRALSIDLSSYGFKIHKYDTGEVVAHQKTPPGDPTAPMFNGHRGELHKVVFEYARDELGIPIHLGQKVTKYFEDEKEASIELEDGTKVTGDIVVGSDGVRSRARTLVLGYEDKPKSSGYAVWRAWFSNKDMIADPRTAEFCNNGDTFNGWIGPDVHFLFSTIKNGSDCCWVLTHRDEHDIDESWSFPGKLEDVFKVLEGWDPMCKAIIEKTPSIVDWKLVYRDPLPTWTSKNGRICLLGDAAHPFLPTSAQGATQALEDGVTLAVTLKRAGKENVPAGVRAYQEIRYDRVRAVQKTGETTRDMWHKADWDKVKKDPKSIELPREDWIFQHDAQKHAEQVYDDVVKKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI14</accession>
    <name>A0A194XI14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_490059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073762.1">
        <property type="nucleotide sequence ID" value="XM_018207889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI14"/>
    <dbReference type="GeneID" id="28817615"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_490059"/>
    <dbReference type="InParanoid" id="A0A194XI14"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="161" mass="17895" checksum="37839CBFBB23CEAF" modified="2016-10-05" version="1">MSIVVRENECDERRKKEVWKLEAGSLGKSRCRSPKFSVPDCQTSSTSSSPADGQLEISPIKSSPVSLVHPKNERTEIYFVLFLVSKYTAGFLLVCSCENCPMTGIPSDGVTACSESKANGPSHFLGLEHTELRQFRDVNRDGSIALEQQVQDVEYQLREAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI93</accession>
    <name>A0A194XI93_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_642557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073842.1">
        <property type="nucleotide sequence ID" value="XM_018211756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI93"/>
    <dbReference type="GeneID" id="28821482"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642557"/>
    <dbReference type="InParanoid" id="A0A194XI93"/>
    <dbReference type="OrthoDB" id="3433125at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="556" mass="61105" checksum="567B788BA31DCC2F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ09</accession>
    <name>A0A194XJ09_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_580636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074498.1">
        <property type="nucleotide sequence ID" value="XM_018209070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ09"/>
    <dbReference type="STRING" id="149040.A0A194XJ09"/>
    <dbReference type="GeneID" id="28818796"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_580636"/>
    <dbReference type="InParanoid" id="A0A194XJ09"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="34351" checksum="BEE012D079419F94" modified="2016-10-05" version="1">MSKLLTVFGATGMQGGSLIHHILNRPELSKLFQLRGITRDASKQAAVSLRERGVEIVQADLSDPVSLEPAVAGSYAVFAVTNYWDNGSCSAAIEIAQGKAVADAAVQAGVALLIWSSLPNITEITNGAVTTIHHFDSKAEVETYIRGLPITAAFFMAGWYMQNHKFLMPPKKNDDGTVVFSQTWSPTTVVPMIDITDTGKFVTPILLNPDKYNGKSFTCATAFYTPIQLVDGWTTVTGRTVTYEQIGSDKKQGNLTAEMQKQLKDSTEGINTWSYFGPNGEKDLEWTLAQLEEKLTSWEEFLRNNEPWFPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJA0</accession>
    <name>A0A194XJA0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase group protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_639762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074680.1">
        <property type="nucleotide sequence ID" value="XM_018211635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJA0"/>
    <dbReference type="STRING" id="149040.A0A194XJA0"/>
    <dbReference type="GeneID" id="28821361"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639762"/>
    <dbReference type="InParanoid" id="A0A194XJA0"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="84937" checksum="B28FCDAEA66C5B5C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL39</accession>
    <name>A0A194XL39_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_778541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075248.1">
        <property type="nucleotide sequence ID" value="XM_018222217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL39"/>
    <dbReference type="GeneID" id="28831943"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778541"/>
    <dbReference type="InParanoid" id="A0A194XL39"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="60058" checksum="A507123F8BF9E09A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL84</accession>
    <name>A0A194XL84_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_682261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074892.1">
        <property type="nucleotide sequence ID" value="XM_018214471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL84"/>
    <dbReference type="FunCoup" id="A0A194XL84">
        <property type="interactions" value="1221"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL84"/>
    <dbReference type="GeneID" id="28824197"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682261"/>
    <dbReference type="InParanoid" id="A0A194XL84"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ20537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="183" mass="20977" checksum="DA39F2135A2809FB" modified="2016-10-05" version="1">MGLTFSKLFDKLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWYIQSTCATSGDGLYEGLEWLAQTLRKAGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLJ6</accession>
    <name>A0A194XLJ6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_665474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075361.1">
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XLJ6"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_665474"/>
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    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="29490" checksum="514F956B3C557DB8" modified="2016-10-05" version="1">MLGCPCHDCDGATSCVFTTKVQKHSEQVTYLLSSAQDAVTLIVGQTKARIVCHKILLAYYSGYFNGLLYGSFAESAQAEITLLDDDKDDMRAFVNWVYTGNIFTCHPVSGQTYGAQTKDMVDFKRIPERMWVFGDRLLAPSYSNDSMLAIMSKYRIMFLFPDAAAFVYENTVSESKLRSFIRVLIRSEGPLARSDSSPFRPSVSDWQKILSKNGELLSDCILYGLANKDVDNIPYGAGNRHLYFENDPSPPVADWFEAKGTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLK4</accession>
    <name>A0A194XLK4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLK4"/>
    <dbReference type="GeneID" id="28824223"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682361"/>
    <dbReference type="InParanoid" id="A0A194XLK4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7140" checksum="143DEF90549D142C" modified="2016-10-05" version="1" fragment="single">MNEIQKLKKPNKKSPRSHRLFRNRDHIEAAVRTAIAALSIVALSIVEIQIGSFATTQRISRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLV0</accession>
    <name>A0A194XLV0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_779457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075097.1">
        <property type="nucleotide sequence ID" value="XM_018222293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLV0"/>
    <dbReference type="STRING" id="149040.A0A194XLV0"/>
    <dbReference type="GeneID" id="28832019"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779457"/>
    <dbReference type="InParanoid" id="A0A194XLV0"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="28017" checksum="505186E2621596A6" modified="2016-10-05" version="1">MPEFTPDQVAFVTGAASGIGLAISKQLILDGITKIAALDISESGLSTAFESSSAKVLQLVVDCSSESEIEAAVEKTVAEFGRLDVCVNAAGIPSAGPRVKIDELEKGNTEKVLELNLMGVWLCERAQIRQFLKQEMRHVSTGLPLKTRGSIVNLGSLTSHVAIPALSPYIMAKHGVLGLTKADAHDYALEGIRVNCICPGWIRTQMTSSLRDNPEVSEAVVTRAPMARWGHPEEIAFTASFLLSDKASFVTGASISVDGGYGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMX3</accession>
    <name>A0A194XMX3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_705207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075863.1">
        <property type="nucleotide sequence ID" value="XM_018217438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMX3"/>
    <dbReference type="STRING" id="149040.A0A194XMX3"/>
    <dbReference type="GeneID" id="28827164"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705207"/>
    <dbReference type="InParanoid" id="A0A194XMX3"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012091110" description="cellulase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="52"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="39960" checksum="CC5888D40A0D6D0E" modified="2016-10-05" version="1">MLLFTLSLLITAAYAVSPLAGVNIAGFDFGVDITGTANLASADPPLTALGGSDGAAQMSHFAKQDSLNLFRLPVSWQFLINSQSLTGSANNGTMTNGTMGNATHTNSAAGALDATNSNNYDQLVQACLATGAHCIIDVHNYARFNNEIIGQGGPSNEEFANLWSQIAAKYKNETNIVFGIMNEPHNIPDMKIWAATVQAAVTAIRTAGATTQMILLPGNDFTGAQTFVSNGSAGNLSNVHNLDGSNTSLIFDVHKYLDADGSGQALDCSSNHITDTFMPLAMFLVANKRQAILSETGGGNSASCLTDLCNTLTFINANTDAYMGYVGWAAGGFSPTNYNLTMTPIGSAGNFTDQPIVKQCLVGTRMGGGIASKKRMVRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN34</accession>
    <name>A0A194XN34_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_778073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076030.1">
        <property type="nucleotide sequence ID" value="XM_018222180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN34"/>
    <dbReference type="FunCoup" id="A0A194XN34">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="GeneID" id="28831906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778073"/>
    <dbReference type="InParanoid" id="A0A194XN34"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="316" mass="34599" checksum="F258BB2E8C9CB5A6" modified="2016-10-05" version="1">MTFSPDTLPDLKGKVFIITGGNSGIGYYTVSHLAEHGAHVYMGVRSLEKGTTAIANIKKVHPSANIDLLQMDLMDLASIVAAAKHFLTHETALHGLVNNAGIMATPFEITKDGHEAQWQTNYLAHWVLTEHLLPLMLHTAKALPPGSVRIVNISSSGHLSAPKSGINFEDLSLKESGTWARYGQSKLANILHTKTLHKEYGPGSKGEGEIWVSSVHPGLVETNLASSMGESQSGIMSVLSGLRMLGLMYPAEKGAYTSLFCVASRDMKAEQSGAYLEIFKRCMEPRWLSGEAKDEKLAERLEEWTGEVMRREGWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN53</accession>
    <name>A0A194XN53_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_429360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075547.1">
        <property type="nucleotide sequence ID" value="XM_018207460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN53"/>
    <dbReference type="GeneID" id="28817186"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_429360"/>
    <dbReference type="InParanoid" id="A0A194XN53"/>
    <dbReference type="OrthoDB" id="10688233at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="61215" checksum="6E41F6A6371185BC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP40</accession>
    <name>A0A194XP40_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_681292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076286.1">
        <property type="nucleotide sequence ID" value="XM_018214256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP40"/>
    <dbReference type="FunCoup" id="A0A194XP40">
        <property type="interactions" value="1154"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP40"/>
    <dbReference type="GeneID" id="28823982"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ21931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="11127" checksum="74698DA0CD7A9253" modified="2016-10-05" version="1">MTSTIGIPIKLLNEAQGHVVTLEITSGQVYRGKLLDAEDNMNVQLKDITVTARDGRVSHLDQVYIRGSHVRFFIVPDMLRYGPVLLFLITDTAVFGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPY5</accession>
    <name>A0A194XPY5_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_778181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28831916"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778181"/>
    <dbReference type="InParanoid" id="A0A194XPY5"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16032" checksum="C17CEB58DF7C772A" modified="2016-10-05" version="1">MSHPHPSSHALDDELLSPLTRISRAPSPVPSIPPPAYTPRTNSEIPPVPSIPSIPNSYPREPTYKSPPSPTPSIQDPYYPTYPTSQFRAMNASSSSSSSSLDEIEGKIATARERRCSGTALIVMGFCVGGVVVAGVVVGAWFGSLRWRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ41</accession>
    <name>A0A194XQ41_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_681239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28823968"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681239"/>
    <dbReference type="InParanoid" id="A0A194XQ41"/>
    <dbReference type="OrthoDB" id="5308542at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268551" evidence="1">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="261" mass="27254" checksum="BB6961FDDB0F497C" modified="2016-10-05" version="1">MSVLNMHIIIHSLLFLATVIPAAHAFTNGSLIPAYFCNPKPDGLPKSLGELIPFTVKDQNNALAFNSNASANLNVVAVTNSQPGNTGYMLASFHNTVNRITPIEPGLGVTLANSTSTSLIAGKPNLLILDSLAAGVALDGAMLHARDADGVPVGSFSDTGGVFVVFPGCGKNKEGGWNGVVHSMVIGCNQTYTKLSYHAPKCAPGPITLGGLSVTDNGFGVWNKTFEVSGSECKTNGTTKAAKVVVEELEEVGVGKRFWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS23</accession>
    <name>A0A194XS23_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_728959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077204.1">
        <property type="nucleotide sequence ID" value="XM_018219329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS23"/>
    <dbReference type="GeneID" id="28829055"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728959"/>
    <dbReference type="InParanoid" id="A0A194XS23"/>
    <dbReference type="OrthoDB" id="3530645at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="35933" checksum="71F5D01010B1B097" modified="2016-10-05" version="1">MPPASGFPNQSTAELASNTLWEYQLRKENKVILEQIRKIGEKRDADVSENMRRMQEGEKHRLTLEAKVLDLEKERKLQDARAAEHERECAAKMAEMEKHLRSRLTDEELQKVMSRVQQMNNPVQTATEPQPATVAPRPSQPKTRLIGEATRQEPAGMLTGPLREKVSVPPSKPRVANRRPSTRSNSEGAPLRAEPVPAKEAAAIIPKLIQRHKALKQYYEAANDAFESLAITDPQIEYDFIAAFLSGLENKKTADKVIQALMALHPARGTLDGGIKLMCGWEDVAVGFKRAGFDVTGAKEEIKRKKRTLNPRTQLETGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTU9</accession>
    <name>A0A194XTU9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_535916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078105.1">
        <property type="nucleotide sequence ID" value="XM_018208099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTU9"/>
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    <dbReference type="InParanoid" id="A0A194XTU9"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
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        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="129" mass="13694" checksum="68FE58AD20FFD71F" modified="2016-10-05" version="1" fragment="single">IFIAEINGRTTGAGNEVAVQCDIRYAGPGAKLSQLEVGFGLLPGTGGLQFLVSLVGRARALEYILSARSVDAFEAAAIGWVNRAFESEEKLKAATTELAERIAAFPKQGLAAIKSRVNVQKPTEQEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUZ3</accession>
    <name>A0A194XUZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_4588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078209.1">
        <property type="nucleotide sequence ID" value="XM_018207669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUZ3"/>
    <dbReference type="GeneID" id="28817395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_4588"/>
    <dbReference type="InParanoid" id="A0A194XUZ3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="25632" checksum="B375D629E783075E" modified="2016-10-05" version="1">MEEIMEQHSDTHSDEDSQSLYEGEMTPSPGLDSTETDTPVYFSGYTECRVRRSSSLYSQPPGGWGSDDTPINLKQPLKSPEARAREAYNPNPSPRLLPRPPPSTPALSRSSLSSTGSRISCGLEHFETAPQDSSSISRCEGAPSMKTYHFVTEIIASGAVPWSFYWHTPGNVQHFGARHDEEMDAAGANGVDLKAFLDLLRRMLVNVAQDSAANEAEDEMASESEQHRDGDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV88</accession>
    <name>A0A194XV88_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_604188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV88"/>
    <dbReference type="STRING" id="149040.A0A194XV88"/>
    <dbReference type="GeneID" id="28820073"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604188"/>
    <dbReference type="InParanoid" id="A0A194XV88"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="649" mass="73433" checksum="A2B33365337AEBE7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVR4</accession>
    <name>A0A194XVR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_605054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078775.1">
        <property type="nucleotide sequence ID" value="XM_018210379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVR4"/>
    <dbReference type="STRING" id="149040.A0A194XVR4"/>
    <dbReference type="GeneID" id="28820105"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_605054"/>
    <dbReference type="InParanoid" id="A0A194XVR4"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF9">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="43376" checksum="11270CD92B078DE9" modified="2016-10-05" version="1" fragment="single">MLAIPDDGGAMPIHRARIFRRLLFAVIASILLYILIAYEPVNLPALAFAPSSPHQTVYNRRPVYEYTSLYRVKANISFEERLEEQLVNLESEIRSKAEKERDLTAKKRIWQITTPELADVWKSWTAQWRDNNAGWEYKLYTSPPTDLLPLFDSVPEIAEANQTFLSIREDLTRYLILWYHGGFWTAIDTWDRVAMRDCNPVVQVVEGRNDVSLMIGVDNDEPYLSSGSLKQWGWTRGFGFGQAVVWAPKRFDPILRKAIVRTISHAMRQLSKIGGKVDYSGELSGASMFTDIVLETLSTHLARDHRLRDRDAGLEKRVTWKKFKHLTEVLWLEKEKPESDMPGVAVLPVNVWGSGQSHSRSGPSESDDACVNHVHGWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVU1</accession>
    <name>A0A194XVU1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_16625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078611.1">
        <property type="nucleotide sequence ID" value="XM_018205528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVU1"/>
    <dbReference type="GeneID" id="28815254"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_16625"/>
    <dbReference type="InParanoid" id="A0A194XVU1"/>
    <dbReference type="OrthoDB" id="3599678at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="284" mass="30313" checksum="EEBEB4DB4657F2B0" modified="2016-10-05" version="1">MRLRGRGKSSSHVSNSSMFSRCHLLSKAAGRGNPSARPLWTRVYTMIGGLAVTLFFIGLMIFLEKTLPDGSKSQFHPTWRRDVSLEPRNPQTDITETLVVETSSSTGLAFTSSSITSSLNAPVITLPPSSSIAAASSSSVDPCISSTVSCIDTDCFTLFSTQASCLPPSSSPPVIPTSSSDPCVTTKVYCVETDCYQVISTQASCLPTTSSLPSVPSITPTSIVNPCVTSSVSCIETDCFTLFSTQASCLPAISGPPSKLFTFVQLFVSRTDHHIYTECRPLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW97</accession>
    <name>A0A194XW97_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_679567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078771.1">
        <property type="nucleotide sequence ID" value="XM_018213895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW97"/>
    <dbReference type="GeneID" id="28823621"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679567"/>
    <dbReference type="InParanoid" id="A0A194XW97"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="52" mass="5950" checksum="DEC8C09A05ACCE0A" modified="2016-10-05" version="1">MAIEKRDADFLSVRTKQHKDMSGKGGDPKGKYFRESLPSRVGIRCYTERSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWK9</accession>
    <name>A0A194XWK9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_604526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078467.1">
        <property type="nucleotide sequence ID" value="XM_018210363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWK9"/>
    <dbReference type="STRING" id="149040.A0A194XWK9"/>
    <dbReference type="GeneID" id="28820089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604526"/>
    <dbReference type="InParanoid" id="A0A194XWK9"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="31120" checksum="4C4441B116E9732E" modified="2016-10-05" version="1" fragment="single">MTVPEKDHWSSQAYQNSASFVPKLATKVLQWLDVQKDDIILDVGCGDGVLNLQIAQTLAQGTGKIHGVDSSASMISTAQKAASADPAASKTCTFEVIDATALLSEPELQQGSFDKTFSNAAMHWILRPESKRKHFFLGVRNSLRSGGNFVFEMGGMGNVAEMRTALLSVIGRRVGLEKVREIDPWFFPDEIWMTKMLEEEVGGWKVERIEREYRPTKADQGGIEGWVRLMGKQFFDAVGDGEERLECEREVCEVLKTVCESPGGGEWIGYVRLRAVVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWS2</accession>
    <name>A0A194XWS2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_713093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078542.1">
        <property type="nucleotide sequence ID" value="XM_018218027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWS2"/>
    <dbReference type="FunCoup" id="A0A194XWS2">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="GeneID" id="28827753"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713093"/>
    <dbReference type="InParanoid" id="A0A194XWS2"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF3">
        <property type="entry name" value="PROTEIN RDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="63873" checksum="97264C09B86300B5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2A4</accession>
    <name>A0A132B2A4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_770969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947454">
        <property type="protein sequence ID" value="KUJ06169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060524.1">
        <property type="nucleotide sequence ID" value="XM_018221874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2A4"/>
    <dbReference type="GeneID" id="28831600"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770969"/>
    <dbReference type="InParanoid" id="A0A132B2A4"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="265" mass="29375" checksum="EA19C3AA308DA388" modified="2016-05-11" version="1">MQHLCCSRATLPLGYSHQALLDCLSVDTFVGGLYSFISGSNGTRAIPFFQYLSTNLVEADLGSIVSVSSVETMLIAMSTAIRELLRREQRAAFHDDLLDLVNSLENATDVTGMDKQCVAFQNVINRIGELRATIARANSLLNHEEVPRVSGVSTAIATSTYPRDTIVPGDRHDNDNTDNTDITKIQILPTEMEIRSSLPEFLPSTDLGQPHFLNDQAERHLDTHFRLLRHDIFGELKDATERGVLYPDWGSPTATSSDQQLWTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2T2</accession>
    <name>A0A132B2T2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_603472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060704.1">
        <property type="nucleotide sequence ID" value="XM_018210307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2T2"/>
    <dbReference type="FunCoup" id="A0A132B2T2">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B2T2"/>
    <dbReference type="GeneID" id="28820033"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603472"/>
    <dbReference type="InParanoid" id="A0A132B2T2"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="813"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="314"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118969" checksum="E502025C747ACE49" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2Y7</accession>
    <name>A0A132B2Y7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_768632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061115.1">
        <property type="nucleotide sequence ID" value="XM_018221795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2Y7"/>
    <dbReference type="STRING" id="149040.A0A132B2Y7"/>
    <dbReference type="GeneID" id="28831521"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_768632"/>
    <dbReference type="InParanoid" id="A0A132B2Y7"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287792" evidence="1">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="32836" checksum="3D649356300939CB" modified="2016-05-11" version="1">MFRLSSILLAFITILPLCLAQRPENISICDFYTPSILGENTASNQLLLITIWVNTFVLGNYTTPNIGIPVHGFATPEIYNGTEIALLPYFTGAYNSTNLGGNAGVSKLFLDDGGPVPVLKNMSSNGNTSSAQYQVFNHIYQYFGSIIGCSLQGSPDFPSYQGRTSMYEVHKFMDLDILQMTYFINLVDTAASSLGISLDDASTIGTSLNRAFNTRCASPISISNIDAPSELQSICIAPDCPLDPDNNCSAYPLDGLALAPVNITDNVTVTTGGNGSTIGVPLLLDLLWGLRWIWILNLILLVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B319</accession>
    <name>A0A132B319_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_397492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061147.1">
        <property type="nucleotide sequence ID" value="XM_018207241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B319"/>
    <dbReference type="GeneID" id="28816967"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_397492"/>
    <dbReference type="InParanoid" id="A0A132B319"/>
    <dbReference type="OrthoDB" id="3775006at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18496" checksum="322DE7033DF5B016" modified="2016-05-11" version="1">MAATNKDSLTKLKDLYQAIDSLKPTSTPEEFQTISAFFSPTCTTYLKSMREYDEPSLGRTATISSLQDNLKIQHVVNRHIISQSTSADGLTVYCEMKNRLHVLGQTLDPFYETAVVVFDEEGLITEFKNYSCRSHIVEIVQEQTGLGPYAEVPETRGKSEGKAGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B350</accession>
    <name>A0A132B350_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_790157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061116.1">
        <property type="nucleotide sequence ID" value="XM_018223339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B350"/>
    <dbReference type="GeneID" id="28833065"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790157"/>
    <dbReference type="InParanoid" id="A0A132B350"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="415" mass="47097" checksum="FDA6F02CA79BBC93" modified="2016-05-11" version="1">MKRLVPDQMSFQKINPSHSPCWERASLMAVRSIFVNSDRHADESDFGLKWSRCYAVELIRGRRMDALHAKIVMFVAMRDGRTALGKECKVVEATESPLLHTFNYSAPHYRHITQRAISIVQQSQVISLARPMPKSCLGTILRQYSPKYNQIAAHYDCAKYALISFAAYTHFQATKSPVSEQMCMSHANIALKALQKEIDHFGPSNADAIIVASIALTGSTNNWGQWAVFIDGYSKTLKQMKDLKYKTIFPDLVGHRFQFRKFSSSSDPNPHEMPKDRDLMRQGVSTIMNSISNAKSVIGLAKWHSTGFGCLETLARSINSAVSLENEVEAYHQLAWLRSWMFWIDLRQFDDSKEEHMLTAHFYGLLLAVVPIFPARYQQSLAEACRRMIQLSQEALDGSTVSVYCTKVNERSPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Y3</accession>
    <name>A0A132B3Y3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zip-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_712196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061455.1">
        <property type="nucleotide sequence ID" value="XM_018217959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Y3"/>
    <dbReference type="STRING" id="149040.A0A132B3Y3"/>
    <dbReference type="GeneID" id="28827685"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712196"/>
    <dbReference type="InParanoid" id="A0A132B3Y3"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ07100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="481" mass="51671" checksum="5F7F49DB71D1A836" modified="2016-05-11" version="1">MVEHIDNDTRGWIMCVVSGIACVLGASIICVDVLIRYIPSMRNFKIQESGAFLAASMSLSFGVMLFSALYSMLPSSKKYLILSGFTPSAAAWILLAGFLGGFVGIQIVSRFLHHYMPSHAVGCDHTHEEGHHDHDHSHTNGKGHSHAAHGGINGHAHESTPLLSAQNETSSKLSPHRHGQGFGGDGASQSRGKKASKDKKNKKSGDDDTKSDKRRPSMVEVQKRVMSFVKDTKPNCDSTGPCFGYTDPCGQGCFKFNVNSRRSTIPSRISSSTSLAAAPEIEVVPACSASRTSKPHVHLHEEDDEACESDDEDLEAQHHHHVPENEFLSIGLQTSIAIALHKLPEGFITYATNHANPSLGFSVFMALFVHNITEGFALALPLFLALNSRLRAMFWASLLGGVSQPLGAGIAAAWFKIAGREGHAPGHAVYGTMFAITAGIMTSVALQLFVEGLSLNHNRNLCIAFGFIGMGIMGTSNALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4Q1</accession>
    <name>A0A132B4Q1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multidrug resistance protein MdtA-like barrel-sandwich hybrid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_677994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061743.1">
        <property type="nucleotide sequence ID" value="XM_018213717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4Q1"/>
    <dbReference type="STRING" id="149040.A0A132B4Q1"/>
    <dbReference type="GeneID" id="28823443"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677994"/>
    <dbReference type="InParanoid" id="A0A132B4Q1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058625">
        <property type="entry name" value="MdtA-like_BSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25917">
        <property type="entry name" value="BSH_RND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multidrug resistance protein MdtA-like barrel-sandwich hybrid" evidence="1">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="21442" checksum="D859808591B07EB3" modified="2016-05-11" version="1">MDSPGGYQLIGRTVPVWDRWVATKGKERMWMFKVIDRICFYPVSEETLDDAREFKTTDSLVKIEEGELNLTEYEVWIEETSKEDAEPGRLRLETLKESGLVDELKPSYQMGSSQDERKDEDEILNDTEMIVRADIAGWCWQRNVEEGNMVEAVQELISIESMKMEIKILAPMSRRVVRRNRSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4U0</accession>
    <name>A0A132B4U0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase-like protein SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_677887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061618.1">
        <property type="nucleotide sequence ID" value="XM_018213709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4U0"/>
    <dbReference type="STRING" id="149040.A0A132B4U0"/>
    <dbReference type="GeneID" id="28823435"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677887"/>
    <dbReference type="InParanoid" id="A0A132B4U0"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="278" mass="30471" checksum="2828CBAB25153576" modified="2016-05-11" version="1">MSKALLPLARRSLARNAVRRSAVNAHGGRTLMTLPAFSLEGKTCVVTGAARGLEGGKASIEHITEHISSQPTTRDYKPELRAYACDVTSEQQVQDTWKAVVQDFGRVDVVVTAAGIVENFEAENYAYDRWKKMMDINLNGSFLFAKEAGRHWIEQSIKGNLILVSSMSASICVRPQKQAAYNASKGAVSLLGRSLATEWGPKGIRVNNLCPGYMKTDLIIDLLEKEGKHIEEGWVKDVPMGRLAHPSELQGTIVWMASDASSYLHGSDIVVDGGYCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5C9</accession>
    <name>A0A132B5C9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_742845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061973.1">
        <property type="nucleotide sequence ID" value="XM_018220882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5C9"/>
    <dbReference type="STRING" id="149040.A0A132B5C9"/>
    <dbReference type="GeneID" id="28830608"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742845"/>
    <dbReference type="InParanoid" id="A0A132B5C9"/>
    <dbReference type="OrthoDB" id="3515051at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287867" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="146"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="29820" checksum="04C541C69E1FF9DF" modified="2016-05-11" version="1">MYLVLLPTIILSLSTSALADCTREFLRNATDAYIKVQRDGAVKSPDPAFAVHLSPNLVYTENFAVTPLNNSILNTSLPITHNFSMHDTTACSTFTELVILPTNTTKPYLIHTRIPIVTTTGDWAFNVTGYLHYSSLETWDPIPAAKRDTRAVVQAGGDAYFNRFDNASVVVPWGAPRTRIEGGALVTGTLSGDNCTMVFPDTIVVTDRRYVVDEVMGTVDIFEGFPGLGRSQGNNPMPDSHLFRIEAGKIKYVHTVSHCVERGCGMNGTSPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5J9</accession>
    <name>A0A132B5J9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061878.1">
        <property type="nucleotide sequence ID" value="XM_018216372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5J9"/>
    <dbReference type="GeneID" id="28826098"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691616"/>
    <dbReference type="InParanoid" id="A0A132B5J9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="90" mass="10183" checksum="F632A9D4988B9094" modified="2016-05-11" version="1">MEINLETIIFTAVFAALITWTLAQPDMIITANPTRVLEAEQANAIRKQTLRFYALPILVFLLAMVAVGLWQFCTSVPTIDPYYVSRLGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6X0</accession>
    <name>A0A132B6X0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_691301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062338.1">
        <property type="nucleotide sequence ID" value="XM_018216276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6X0"/>
    <dbReference type="STRING" id="149040.A0A132B6X0"/>
    <dbReference type="GeneID" id="28826002"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691301"/>
    <dbReference type="InParanoid" id="A0A132B6X0"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="38795" checksum="E93802758B0A6607" modified="2016-05-11" version="1">MPGILQKPSRENVRYLDTDRPPRDLLRIWKTTSTPVHPGAVSMSDSSRPTSSGNDDSSGSDSPRPSNVRTYQRVDFSQPYDVAESRARRQAGRNAQGLVAETRSDIRRKKFGLTEAMMKIEELEKDVENMDKNFGKVDEMQETLRKLSKVLPTAEQSHAHKLNCTLESIHDAKEGIERLEEKVSAVPDIPAVPIVPTVSSIAAIPVVPTVPDIPAVPVAPTVPDIPAAPIVPTVSNIPADSVISTVSNIPAVPNVPQSQEKPAIKFNVELGFNLNAPSWKAVWSFMFLLFMLFMGWLLLEAAMCGAYCKPKYSSTGHFKVSDPLFPNALPTKLDEWTGERVSRAWRAFWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B774</accession>
    <name>A0A132B774_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_677751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061882.1">
        <property type="nucleotide sequence ID" value="XM_018213701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B774"/>
    <dbReference type="GeneID" id="28823427"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677751"/>
    <dbReference type="InParanoid" id="A0A132B774"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="116" mass="13308" checksum="6B97718E974B54DE" modified="2016-05-11" version="1">MSVQARQTQTPGFFSPEDKQIIGLIILYGTLSFWAVALPILIFQNRANIRTWWMERRRRRQIWGCEVNVDGISGNLGSGDIVKRSEESIHDIPEDERVQMDLSTRVSGNSPPDHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7C5</accession>
    <name>A0A132B7C5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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            <end position="198"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="28986" checksum="289F85B4A9622DAD" modified="2016-05-11" version="1">MSSFCIAQIPAKPRAPKMRPRYESVTSRNLPPTFISVDSLVNAPTIEVGRDVLQASEKWLASEYAPQLAMTIAQIIADRAGQPISNIVCLGIGNRRARDIDQFVLLAQIATQLSVAQPSILDNIVAQDPNMSPEMKGLFQIHGCRVVEDPEAFGFVGPDTFLFAPFLPIFAVLRGLRNRGCTDFGMYIGNDLKRMVGGPEKNSHRFGVHESDQASFEQIALSIQDETVCKRSMVPCDTPVGLRGTFRGLRDLEIWWRPVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
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            <dbReference type="EMBL" id="KUJ08470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="68" mass="7322" checksum="E60A4B23551DD2EF" modified="2016-05-11" version="1">MPAPAYLISKVADPVFAVFIGLSAAATRINREEKELGHSTQQTIDAGLRRIGLRGQEAAVTKREQADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B890</accession>
    <name>A0A132B890_MOLSC</name>
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    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28832965"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789329"/>
    <dbReference type="InParanoid" id="A0A132B890"/>
    <dbReference type="OrthoDB" id="10595582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
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            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="32549" checksum="04C0CC0A74A5CD31" modified="2016-05-11" version="1">MTQVTPLQSYLRPRTSRILPLWKLSYLLQLASPVLLLGLAVYSFMTHTPAPNAKFTGEEFLPVVLIPQPLIHFSLLYFTDFTFKLPRLPENKNADEIASLVETYIDPKRGTAFLSTRRQQIEDFALYLADPNRHAGNLFSRTRNTVLGSFYLALFLFTWSMLYALDICVVGGCNIVWKLLMWTEFCLMTFSVLIYAIETPWYLHMGRLARNIRMECMCVHSEKAILGKESLAEIIERLLELFEDENVDRDERRNVIRASIRDDDRQGWGVFGRGEKRVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B953</accession>
    <name>A0A132B953_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063295.1">
        <property type="nucleotide sequence ID" value="XM_018218905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B953"/>
    <dbReference type="GeneID" id="28828631"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724503"/>
    <dbReference type="InParanoid" id="A0A132B953"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="98"/>
        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="60530" checksum="583E4FDE3C25A259" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9S0</accession>
    <name>A0A132B9S0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9S0"/>
    <dbReference type="GeneID" id="28823360"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676837"/>
    <dbReference type="InParanoid" id="A0A132B9S0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="182" mass="20764" checksum="2B35C12AFE3927F6" modified="2016-05-11" version="1">MDGRRLDFQSVTAVLPRLNEIHCWKHDPQIDFTLPGQQQIHCGNLVFSQQQMHSNYFTGGCFLVEVELNFKKCTDCREEEHSRHDSVRNGVCLPFSLALALDFLLLSAQAKLSPKYASQEATSGRDTSHQFKNHSAQGNIRDSVEHTKAFEAVLGRVRLSMTRKDEPKRLFMPTVLDGIDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Y5</accession>
    <name>A0A132B9Y5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_280048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063570.1">
        <property type="nucleotide sequence ID" value="XM_018206446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Y5"/>
    <dbReference type="GeneID" id="28816172"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_280048"/>
    <dbReference type="InParanoid" id="A0A132B9Y5"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="39"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="35629" checksum="9DC5AAE283412432" modified="2016-05-11" version="1">MATTTTTTTTTALPASSLGPITIAVGAVFLGINAFFIGLRCYVRARISKTFNFNDVFMIVATFIYAGLFALLIFAVRNGVGGHTSSATIVGIGNALKFIFFLEIIYVVLTSIMKASLAITLLQWAKVKTHIYLLRAAILIDALICIIVVEYFLVQCAPISYTWRLVDPTAKGVCLPAAQQIAVGFALSGTTVSIDMLFLIAPWIMLKGRGVNSRLKLYIYGLFGLGVAASIANFIRLATLAKLKASTDPLFDAAPVFLWSAVEVSIGIAVAGILELRPLMRKYNVKGFEDSFDQIDEDRIPIRLQSMDKSNISFPTTREMGNQGRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA46</accession>
    <name>A0A132BA46_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_658590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063224.1">
        <property type="nucleotide sequence ID" value="XM_018212481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA46"/>
    <dbReference type="STRING" id="149040.A0A132BA46"/>
    <dbReference type="GeneID" id="28822207"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658590"/>
    <dbReference type="InParanoid" id="A0A132BA46"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="695" mass="78363" checksum="C4819A6615B25BEB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAE0</accession>
    <name>A0A132BAE0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_657727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063730.1">
        <property type="nucleotide sequence ID" value="XM_018212441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAE0"/>
    <dbReference type="GeneID" id="28822167"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657727"/>
    <dbReference type="InParanoid" id="A0A132BAE0"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="45034" checksum="7C744A1E291C838C" modified="2016-05-11" version="1">MSPPRVLIIGCGVAGPAIALLLKRKGYSPIILEKVRQLGDVGGSLMLFPNGLKVLSLLGLSSLATETAPNLTCLRDISSNGTEIGDTKLPATWRAKYGQPACGVKRTALNLALKEACLDAGIPVLEGWKLKDIIETENSVTAIAEDGRMEEGAFLIGCDGIKSATRNLVLKGHGMQEEDTTFTNLTQAGGMSPTPSILKQTPGMMNWYGEGAHFIAYPISKTTTSWAITQRSNIEEVETWQQMSVSQLAVYKSNLLAESQTWCEPIQDLIKGSERLIKYGLFDRPQLEKEKWVSEAGRCVLIGDAAHPTSPHLGQGANQALEDCWHLARLLPDGEVEMERKTLKEMFLEFSGLRQPRTAALVRGARAQGERRVVSGTEECRRRDEALRRGWMDELAVEEKWESLLREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAT2</accession>
    <name>A0A132BAT2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_598578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBF5</accession>
    <name>A0A132BBF5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_741467</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="KUJ09174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18727" checksum="E187143DFA652DA8" modified="2016-05-11" version="1">MVSSSSERRYDIIRDQLNAYALFLAENDLSQFDLDELYTMLRSIDRWGKHLYRFFGQYLSPPKNKVDFRYCHDEERERALHLKSILDGLQSSFRTHINAVSRPYLRPLTIRDMPNKILSKIFECVKGSKASTIVISMFPVVLATSRTCSLYVNASTTTAVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="583"/>
        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
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            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="586" mass="64424" checksum="64587D0285C93DF7" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCX2</accession>
    <name>A0A132BCX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_711259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063862.1">
        <property type="nucleotide sequence ID" value="XM_018217892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCX2"/>
    <dbReference type="STRING" id="149040.A0A132BCX2"/>
    <dbReference type="GeneID" id="28827618"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711259"/>
    <dbReference type="InParanoid" id="A0A132BCX2"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="35927" checksum="43D6C29D26FBD347" modified="2016-05-11" version="1">MASMEKIFSDYDARKLHLESSDNQFAKGVAWVEGELTPLSHARIPLMDQGFLHSDLTYDVPAVWDGKLFRLDDHLERLNLSCEKIRLKLPLPREEIKQILMDMVAKSGIRDAFVELIVTRGLKGVRGSKGEMVNKLYMFIMPYIWVMEPEVQRAGGSAIIARTVRRVPPGSIDPTVKNLQWGDLTRAMFEANDRDAMHPFLTDGDANLTEGSGFNIVLIKNGVLYTPDRGVLHGVTRKSVMDVAKANGIEVRVEVVPVELAYQSDEIFMCTTAGGIMPITVLDGKPVNDGKIGPITKIIWDGYWKMHFDSAYTLAVDYGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD77</accession>
    <name>A0A132BD77_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_740063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064693.1">
        <property type="nucleotide sequence ID" value="XM_018220543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD77"/>
    <dbReference type="FunCoup" id="A0A132BD77">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BD77"/>
    <dbReference type="GeneID" id="28830269"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740063"/>
    <dbReference type="InParanoid" id="A0A132BD77"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="86"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118349" checksum="4C676918548C7359" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEJ4</accession>
    <name>A0A132BEJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_261200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064784.1">
        <property type="nucleotide sequence ID" value="XM_018206273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEJ4"/>
    <dbReference type="GeneID" id="28815999"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_261200"/>
    <dbReference type="InParanoid" id="A0A132BEJ4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="134" mass="15251" checksum="2179F8C2F45C0544" modified="2016-05-11" version="1">MSTASERASVEILYGTVQFVVRSLSLDQSVNSYKCTLEPFPSRSAAPPYHFGVRCTLRGFWHLFLFCFVFFCFLFVYSNHLGPGIEGNQDSRTATRKSRNSFFFLYNHPSIARHVSGRKQKPISNLMAGRGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRX4</accession>
    <name>A0A194WRX4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_689376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065088.1">
        <property type="nucleotide sequence ID" value="XM_018215895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRX4"/>
    <dbReference type="FunCoup" id="A0A194WRX4">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRX4"/>
    <dbReference type="GeneID" id="28825621"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689376"/>
    <dbReference type="InParanoid" id="A0A194WRX4"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="752" mass="83047" checksum="DD1BCF6E831DE7EA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSX8</accession>
    <name>A0A194WSX8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_722926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065413.1">
        <property type="nucleotide sequence ID" value="XM_018218772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSX8"/>
    <dbReference type="STRING" id="149040.A0A194WSX8"/>
    <dbReference type="GeneID" id="28828498"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722926"/>
    <dbReference type="InParanoid" id="A0A194WSX8"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="299"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="51771" checksum="BCB5EAAA7420A66A" modified="2016-10-05" version="1">MSNNSYIVRISKELSDLQKSSDLSLAVACRDIDVRNVKAIIIGPPDTPYEFGFFEFAVKFGKDYPGKAPSVNATTTNGGRCRFNPNIYAGGKVCLSILGTWRGERGEEWSSAQGLESILISIQSLMSSNPYENEPGFETANTDDDKKNQKAYVAKIRHESLRISVIQRLEDYLGISADGAVQQVPSINEEDDIDEEMHEMDRDAFDEASASFDPFRDLCKRRFLWYFDSYLLAISKAKSEAEDEQSFTRMPFECSGNIMEGKFNYTELERRLRLIHKTMKVETARWAEEGLASIKKESSVASNLQRQYEQVVESYKRDKTVTLDVELVDKNPFVWAITYFGRPMTNLDGGLFRIKLFFSPRFPEEQPRAKFETQLFHHRIASDGTPCYTSKRSEDVKSHIDAIIEALEEEEPPYDPRTLVNPEAAKLYWGSADDKKLYNRKLRRAVQRSMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT99</accession>
    <name>A0A194WT99_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_700440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065531.1">
        <property type="nucleotide sequence ID" value="XM_018217122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT99"/>
    <dbReference type="FunCoup" id="A0A194WT99">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WT99"/>
    <dbReference type="GeneID" id="28826848"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700440"/>
    <dbReference type="InParanoid" id="A0A194WT99"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="252" mass="27327" checksum="0FA7EB95086CBDBA" modified="2016-10-05" version="1">MSPPAIIAPSILSADFADLGAECSNTIKRGATWLHIDIMDGHFVPNITFGAPVVTKIRSHVERPTTKHGKGTFDCHMMISEPKKWVKEFQKAGCDLYCFHYEAAIDSTAAESPESTSELKTNPRELIRYIHECGMLAGIAIKPETSVDVLWDILASNQEKEVPDMVLVMTVHPGFGGQKFMASELPKVAELRKRYPELNIEVDGGLGPGTIDQAAEAGANVIVAGSAVFGAKDPAEVIAKLRDAVESRRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTB7</accession>
    <name>A0A194WTB7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_689105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065553.1">
        <property type="nucleotide sequence ID" value="XM_018215843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTB7"/>
    <dbReference type="STRING" id="149040.A0A194WTB7"/>
    <dbReference type="GeneID" id="28825569"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689105"/>
    <dbReference type="InParanoid" id="A0A194WTB7"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="323" mass="34660" checksum="461CBF3851C88DD8" modified="2016-10-05" version="1">MAPRILIFGTGSIGAAYAYILSRAVPASNIVTVCRSNFEAASQNGFTIHSSLWGENQKVQPVVVRSVDEAAPTDPELGFDYVLITSKALQTVPSTPELIKPAISPKTTIVLIQNGIGIEEPYVKLFPNNPLLSTVVYLPATQTAPGVVLHKELELLHIGSYPASSNTKSASKLADLLTSAGASSKVHEDVQFERWSKLLINASWNPICALTRSRDVQVLRSSAEAEEYVRDVMLEIAAVANACGYQEINAALIDFQLGRAVARDLPGVEPSMMADALAGRKMEVEAIVGNVVRIAKERGVKTPLLRSIYVLVSALDSSFGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU56</accession>
    <name>A0A194WU56_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_239627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065564.1">
        <property type="nucleotide sequence ID" value="XM_018206100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU56"/>
    <dbReference type="GeneID" id="28815826"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_239627"/>
    <dbReference type="InParanoid" id="A0A194WU56"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35645" checksum="D75AAEE518F1B65A" modified="2016-10-05" version="1">MTKSPHALSLPAPSEKQTYVTISALEAGHLTLPEHLFVTNAAPEKRTTVPSLAFLIRHPSPSKILPSQSTNLIFDLGLKRDFTKYRTAQQHHASQRQPTITSLDAAASLRAGGVDPEKDVDTVILSHVHWDHVGTPSDFPNSNFVVGSGTLHLLANGAGPLYPAELFNADELPFDRTYELPSSNSSDAGKAAKQQTAHKWEPLADFPAVVDYFGDGSVYVVDSPGHLIGHVNLLARISPTKWVYLGGDCCHDVRILTGESDVAMYDDGRGGLRSVHLDTDAAKETISRIGGLLKRGEVVTDGGGEVDVEVVVAHDKGWSEGNKGRFLPGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUB1</accession>
    <name>A0A194WUB1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_227160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065905.1">
        <property type="nucleotide sequence ID" value="XM_018206002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUB1"/>
    <dbReference type="FunCoup" id="A0A194WUB1">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="28815728"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_227160"/>
    <dbReference type="InParanoid" id="A0A194WUB1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="65"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="258" mass="29359" checksum="D21D70C4C615859F" modified="2016-10-05" version="1">MSTPLEDKEVPRKLRKAFEKEKKKARARALHSQPLRKINTQGLQYLRKSLGLLSDSQKVDTLDAVFIAIDFEYSNFSAKTGRIRLREVGISTLDTRDTRYKEPGKIISSQHYRTVMDTKEFLFGVSIDTTQDDLVSLLKHLLYPENNSGKQPRQLILVGHGFSFEIQVLRGLGINLALAPIVENILDTHYLGIEVFGQDFSLSRLTRQLGLEGSHFHNVGNDAKFSLRAMLLLATHNLLEAESSQQSRSEIYERIARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV43</accession>
    <name>A0A194WV43_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_653304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066196.1">
        <property type="nucleotide sequence ID" value="XM_018212244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV43"/>
    <dbReference type="FunCoup" id="A0A194WV43">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="GeneID" id="28821970"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653304"/>
    <dbReference type="InParanoid" id="A0A194WV43"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="2">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="213" mass="23396" checksum="32EDC729C795F6B7" modified="2016-10-05" version="1">MASVITPSFHASDNSEKASIQLLIKALELEPHIEGGFFKETDRAPDTVPSPWESSTSSTSELAPQRPGFAPGLRNSSTTIYYLLTENGPQGGFHRNKGRTVHTLHRGRGRYVIIHADDDGPEKRIETFVVGQNVEKGEKLQWIVDGGKYKASYLLPDQENGTESQGLLISEVVVPGFEYCDHDFLAAEKLTELVGSKKAEELSWLSSPLAKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVW1</accession>
    <name>A0A194WVW1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_221972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066456.1">
        <property type="nucleotide sequence ID" value="XM_018205955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVW1"/>
    <dbReference type="GeneID" id="28815681"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_221972"/>
    <dbReference type="InParanoid" id="A0A194WVW1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="135" mass="15322" checksum="9BBBFEBD923568D9" modified="2016-10-05" version="1">MRASEWTIFRGSPNIAEAFLIYSAQSPINGTSLVYDFMSATIVLFILLVVQPFSYIPFLLSLRCHCLQHLWVGNPISQYSGMNIKLSFQLKPLACSESSHVMTVQPFPWFIAKNLSSRSSNEPVHPYTGEMVRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX01</accession>
    <name>A0A194WX01_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_757031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066863.1">
        <property type="nucleotide sequence ID" value="XM_018221398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX01"/>
    <dbReference type="GeneID" id="28831124"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_757031"/>
    <dbReference type="InParanoid" id="A0A194WX01"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="23852" checksum="810591BBCBD9A293" modified="2016-10-05" version="1">MFLAELQGPLIRGRFQLEKRLLTFLTEYSSDHLAIFNLLRYGTSEQLSYAMKLPRPINAMIRTAVQGSKQGKKAKFQTFSKCRASSPTKKNKTTEATTPWNLPCILPGPEMSLPFPRSRAEPGAQTFPATEVGGFEGGGEDIWTYGTGATSTGIGCGIQPYGGWQPVPREMIPKDEKVWGPDGEVVFREQMPTGGEGGSGVDVGSGGEIDVGGGFDFDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXG5</accession>
    <name>A0A194WXG5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_722015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066734.1">
        <property type="nucleotide sequence ID" value="XM_018218695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXG5"/>
    <dbReference type="GeneID" id="28828421"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722015"/>
    <dbReference type="InParanoid" id="A0A194WXG5"/>
    <dbReference type="OrthoDB" id="3478025at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF14">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="422" mass="48266" checksum="D18FCB0BDDF85F61" modified="2016-10-05" version="1">MPYHTALDWHTWLGVEGHTIIAREDLLDVVSQLPPVSDLRGGFHYNNYAYAVVGKVIDQQTGFPWYEFLRARVFEPLGMKRTTTNRKKLPDENLAEPHVVLDDRSIIKPVDVSDDTVMGAAGGVRSSVTDMMKWAKALLDGIHNDTNYSEEKLSSPLKQVSTIVAHRNLITTSSVNENTYALGFARAMTPSTELWMISLNSPLRENVMGRASPSRLVLYHNGGQSGYLSAFYLSPETRSAIVALGNSYGLGDGPDWTCQAIMQAMFDLEPKVDFAEASRRRAQFEFERYERLASDYARHREEASHRKYPRLDDFVGRFENKSLKMSLDIRLPDAENKGPKEEYLILIFNDRNSQHHRLQHYSNDTLGFLPISREELIVREMIDWFDWDQFVLTFRRDESGKVKSVDWALQVGLPPVNFQLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYY4</accession>
    <name>A0A194WYY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_153727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067528.1">
        <property type="nucleotide sequence ID" value="XM_018205433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYY4"/>
    <dbReference type="GeneID" id="28815159"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_153727"/>
    <dbReference type="InParanoid" id="A0A194WYY4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26465" checksum="C2957408F5A1BBA5" modified="2016-10-05" version="1">MLSAVLVGISISRLQDHYRFQQEYSLWLLTAFGFSALQEAQVTYSFIRIWFKEHSGLEVASKVMVIILSLAELSLFILGFIPFANGIVTYLIRGAPIFFLTTCILCCYPALRFSIKTLKYGRDMKTKLILPILTFFQIFQPLLTTVALTCMWRNASSTYFIHWLWILALSGKACICRIVLQSAWNCVDKRWFSTATTSHLENRIIRNASAGESIQSFNLEAGRRYGVGSISEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYY9</accession>
    <name>A0A194WYY9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_737161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067533.1">
        <property type="nucleotide sequence ID" value="XM_018220223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYY9"/>
    <dbReference type="GeneID" id="28829949"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737161"/>
    <dbReference type="InParanoid" id="A0A194WYY9"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="267" mass="31539" checksum="17A7ED900A143F04" modified="2016-10-05" version="1">MATLLAKREAIKSKRTQINDSAYFLKRFRVPSRAQYLAQEENWDSFEKEMAEPNLVPDTDNLRLFAWWSASKSKGRLAEKADIKTLCFNMGRFQRLYNACHKYQIPDEDLKDVREYIRTDVAEELGLQDQEMPKGYADWEDIKIVIRYIIAEDAHVYIDKRFRAQIVCIILLVAENGERLGAIARSESYRQEDIALCYKDVELFLRPASDEHPGPRIKMSITYDNRKNERDKHENYVETYFQRTDLAHCTILWFLVLAFLDDAFDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0G4</accession>
    <name>A0A194X0G4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_542185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067799.1">
        <property type="nucleotide sequence ID" value="XM_018208191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0G4"/>
    <dbReference type="GeneID" id="28817917"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_542185"/>
    <dbReference type="InParanoid" id="A0A194X0G4"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23270" checksum="32B49F9ADBBD7E19" modified="2016-10-05" version="1" fragment="single">RVIAVLGATGAGKSTFIQRATSSDKIIIGSTLRSCAYISVWPANINGVNVALIDTPGFDDTERSDSEILEDVATWLAATFEQDILLSGMIFLEPVNANRVSGSEQRRIRLFEKICGKHAFSNVIIASTMWNTVAIWPSSRRTTRNLMKERTNTAGFWGQMMLHGARYEEHADTKASALKIIRMLLQSEPRPLQLQVELQGNGSRLCLTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0J5</accession>
    <name>A0A194X0J5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_158747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067834.1">
        <property type="nucleotide sequence ID" value="XM_018205478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0J5"/>
    <dbReference type="GeneID" id="28815204"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_158747"/>
    <dbReference type="InParanoid" id="A0A194X0J5"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="47820" checksum="1F8A570799B4998A" modified="2016-10-05" version="1">MTSSLRKTRRTHQKSRAGCFECKYRKVKCNEARPVCSGCTKWEVRCEYPCARKSESKIKHQKNMAILRRQLSASSDRELTYEGNGSPTSGNSLLPVPAYEPQLNKPIGYFDVNDMHLWHHFIKSTASTLYNPWLTELPHEALHCDYLMHGILATSAVHLAHLHSDQKDKYNLLACQHQDLALGPFQKAFAEMDPENCVNLFAFSTLLHLFSFVSDWAPKSPLPATYQPPSLQSLSQWIFCIRGCSLIVFQARPAIEASPFGRLIDKGKALQRSLEMGALLSPADDESLTRVKDVALDLPETKRITTVEEMEAYEDAIFRLRNLLAGTNEADDPVMRRAATYIWPVWVSETYVRLLAEKKPPALIILAHYCLLLMKAAGVWFLEARLTGLFNCILEELGEEWWSYIEHPMKMFREMYESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2U4</accession>
    <name>A0A194X2U4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_708712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068694.1">
        <property type="nucleotide sequence ID" value="XM_018217702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2U4"/>
    <dbReference type="GeneID" id="28827428"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708712"/>
    <dbReference type="InParanoid" id="A0A194X2U4"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443866" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ14339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="60868" checksum="098496B44FCF4815" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X342</accession>
    <name>A0A194X342_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_143917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068958.1">
        <property type="nucleotide sequence ID" value="XM_018205335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X342"/>
    <dbReference type="STRING" id="149040.A0A194X342"/>
    <dbReference type="GeneID" id="28815061"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_143917"/>
    <dbReference type="InParanoid" id="A0A194X342"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="48882" checksum="6AF602CC426CC83E" modified="2016-10-05" version="1">MGLTTGQKEVLITIERTTASISVISSVILILTYLSFKDFRTLPNTIIFLASPANLLAGVAALIGGSGLDNVDGTTCQAQAFLLEWFMQSDPFWSLVAAVTVFLVFFRRWGAERITNLYWVYILFCYGIPGVAAFVCLLYKKNGPIYGNASLWCWIDQEYHWARIYTYYGPVWGSIVFSLSIYVAVGIRVYQTRSQLNDARNHPYCGTGRSSTIRSPSLLEQATEVQTTDKAPTIKYPDAVYSPTSATSPPATPPSNYTSTLTSTPVHLMPLHVIFRFMSRAAMLSVSGLRQAWKKWKNMDEVKYKYTKCAGLFAISILVTWVPASFNRIYGIIYPDGRYVYALNIASALVLPLQGFWNAVIFFSTSVGIVKMVWGDVRACRRLVLVGKMLGWGSNVQEINVPLAERRNSIVGMGRSNDSQTRLRASTRLDDESLLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X355</accession>
    <name>A0A194X355_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_589842</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068809.1">
        <property type="nucleotide sequence ID" value="XM_018209562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X355"/>
    <dbReference type="FunCoup" id="A0A194X355">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X355"/>
    <dbReference type="GeneID" id="28819288"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589842"/>
    <dbReference type="InParanoid" id="A0A194X355"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="15">
        <location>
            <begin position="52"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ14454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="469" mass="51009" checksum="74A2F32EAA13BCF0" modified="2016-10-05" version="1">MFSRFVKPAAFKPAGGIYNRLAQQARFLATVEGSVGRAMPATRPRATPISHDRATFTIRDGPVFHGKSFGAKSNISGEAVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSSARDEHGLLKYFESPNIQCVGVVVADYAEKYSHWTAVESLSDWCAREGVPAISGVDTRAIVTYLREVGSSLARITIGEEYDADQDEAFIDPEQINLVKKVSTKAPFHVSSHNGDMHVAVIDCGVKENILRSLVGRGASATVFPYDFPIHKVAHHFDGVFISNGPGDPTHCQETVYHLTRLMETSQVPVMGICLGHQLLALAAGARTIKLKYGNRAHNIPALDLTTGQCHITSQNHGYAVDTPTLPADFKEYFVNLNDGSNEGMIHKTRPIFSTQFHPEAKGGPMDSSYLFDMYIENVQRYKKNQAVYPAGVGKDNRPSPLLVDILSKERVGVAPAQSVENLAQAAAVQQAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3I3</accession>
    <name>A0A194X3I3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF718-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068742.1">
        <property type="nucleotide sequence ID" value="XM_018213236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3I3"/>
    <dbReference type="STRING" id="149040.A0A194X3I3"/>
    <dbReference type="GeneID" id="28822962"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671742"/>
    <dbReference type="InParanoid" id="A0A194X3I3"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="17107" checksum="2ADF2D9BE6F54A51" modified="2016-10-05" version="1">MWKGTSSSSPPASPTQTKIPSVSKPNYRLKNQGKRIAQIVKLKPERVEEYKECHAKVWPEVLKQIKECNIEDYSIFHDPETSILFASFKYVGYNYAGDMEKMRDNPKVQEWWRMTDEMQESMVPGAKSSHDGEPAWWKGVQEVFYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3L9</accession>
    <name>A0A194X3L9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_720241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069121.1">
        <property type="nucleotide sequence ID" value="XM_018218552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3L9"/>
    <dbReference type="GeneID" id="28828278"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720241"/>
    <dbReference type="InParanoid" id="A0A194X3L9"/>
    <dbReference type="OrthoDB" id="3560784at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18113" checksum="141CFB2C65F520BD" modified="2016-10-05" version="1">MDFGFATISLVVQTVLAVTEHRKLLENRNHFLDYSLPTRQTAISHPVSTDIGILCSTCISSGLLTSIYQRGRSGKLQTPLFLATIVGSFASWGMIGVPVDILALTVFEWMVTLVLLVSRYCEHILLSDLEAGDAAFGLERVQKVFGMHDREKKSFSGRDLDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3X8</accession>
    <name>A0A194X3X8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_686501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069245.1">
        <property type="nucleotide sequence ID" value="XM_018215299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3X8"/>
    <dbReference type="GeneID" id="28825025"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686501"/>
    <dbReference type="InParanoid" id="A0A194X3X8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="140" mass="16104" checksum="4F6CDD0956F35F47" modified="2016-10-05" version="1">MQPFDAERTVELFFKLYAVLVNLAYIPFETISFPPHELHPNDLARWGSNMDPVALDLVKKLPYLKTAPFFQAGFTIAPGTISKDFSKDLSKDLSYAQHPLDWYEGDHEYVERWSLCLTNGFDEWASGWLILDTRKGSLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X404</accession>
    <name>A0A194X404_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069256.1">
        <property type="nucleotide sequence ID" value="XM_018215301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X404"/>
    <dbReference type="GeneID" id="28825027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686508"/>
    <dbReference type="InParanoid" id="A0A194X404"/>
    <dbReference type="OrthoDB" id="5411153at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267855" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="126" mass="12911" checksum="6332BC250A6F222E" modified="2016-10-05" version="1">MQLQTIFSLLPLISSAYAGVFIQGFSDGNTATAGCQTGLGSVTIPQNGECVGFPAEWQGIQVAGGGSNECFLRIFQDDACQVDSETQIGPINDPNLGGCIGPFPFDEGGNTVFTGIGSGSLVNCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X491</accession>
    <name>A0A194X491_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_127360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069350.1">
        <property type="nucleotide sequence ID" value="XM_018205207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X491"/>
    <dbReference type="GeneID" id="28814933"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_127360"/>
    <dbReference type="InParanoid" id="A0A194X491"/>
    <dbReference type="OrthoDB" id="3562540at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35557" checksum="26F1E22C5DEBB0D4" modified="2016-10-05" version="1">MSGLELITALGVAASVAQLIEYSLKVIKTISEINSRVKNASSCIAQCNKQIRQLIQVGQAIQGNENFHSDLIACQLQNTLAEVKHLHELLGQVWLDYTTGSSGKRIWKAVVGDKERHMLKSSERLEKEKTSLIICIGVFQSQTLQTIEAGVEILVDRDMPKVQDVLDKLKMSSKKSKAKKHRENVSAIMMPQNNQREQDQTCRSLVVRESVNPDPETGPNEHSGLYRPQLLQADGHSYSGANSNRAVQMNGETGTGLDTNNAYAKSLCENKGFQVNGNYGSSGFHTHKDPLAAKGAFQINGNLGPGVTREELNKWNASEGEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X495</accession>
    <name>A0A194X495_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_751649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069355.1">
        <property type="nucleotide sequence ID" value="XM_018221231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X495"/>
    <dbReference type="GeneID" id="28830957"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_751649"/>
    <dbReference type="InParanoid" id="A0A194X495"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="16717" checksum="CEA2F085D5E4BEDC" modified="2016-10-05" version="1">MLPPPSLPPSLPATINRITKTLSKLRTSLSQHQKTTRSHDRSGLPDHHVLDLSQKLTKLEIEWSVEFRSTDPRRIERFGKKVDALQEEIEKLSKGKTGKERGSGWDEKRSRMAQYESERDAEMRGRHGARGSGGWKTWLSGYCLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4Y6</accession>
    <name>A0A194X4Y6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_750565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069595.1">
        <property type="nucleotide sequence ID" value="XM_018221204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4Y6"/>
    <dbReference type="STRING" id="149040.A0A194X4Y6"/>
    <dbReference type="GeneID" id="28830930"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_750565"/>
    <dbReference type="InParanoid" id="A0A194X4Y6"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24637" checksum="FEB722AC627FE707" modified="2016-10-05" version="1">MAQNIYDNLEFHQHFMHLPSQTHGLAGAPEWLLFRSLIPSVINASILDLGCGAGWAKQTKEFPRSAVVVYKQADLETVGLEKEKFNIVLSSLVFHYIVDLPRLLKEIFESLKPGGSLIFSVEHLLYTQATNPAWSKDATALPGDNYFEEGQQTTDWLADGVLKVHRTFGTYANAMMDAGFVFGGVKEWGMEGKEMKDAEQLADRRGRPRFLISKGMKPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X503</accession>
    <name>A0A194X503_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_671286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069237.1">
        <property type="nucleotide sequence ID" value="XM_018213208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X503"/>
    <dbReference type="GeneID" id="28822934"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671286"/>
    <dbReference type="InParanoid" id="A0A194X503"/>
    <dbReference type="OrthoDB" id="3552116at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="55989" checksum="EC7B295096DB78D5" modified="2016-10-05" version="1">MTPATEGLLAGFDPKNTKSMRRFALSLYHWKKGARFTNSAHLHGLTNQQITTLEAARLRVLIDPEWDILIERFLGTPRNIAPYRPLMQAAKALADHAAGVQAPNILPVSELLTTPQSRPSIGVGPTVSEQTTITNRGREPIDKPLEHSNTTRSVSPISVDVGNFGEALQKIAPFPSSSRGISPGADMSWMSDLEDEALRQAELDDMMKSLNHTPASEVLRNTPGPALSPKNKLAVGPSGQSIVDAASQNADRFENRTSQVKEDHLLAEPFQDEENKEYAEGYRSIIDDWQKRLSRKQSHQSIVPMAQHHATEDSEYDSQSQDFDSESVASEDYEISVTALLASELEEEERINNEEREAREIEAAIQESLKVNNIVPSTSGSFSPSSRPVLGKRSSETSDAIFPSPKRANVESPELVIKHHDNGLFSEEESFPRGYEVVYPGKFGNTKNTLLNSEPSIRSGAPDTIEGFSGLSGGEKVQVPTDVRASGTQSNANESDGKEVHAPKNNCCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X588</accession>
    <name>A0A194X588_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Decaprenyl-diphosphate synthase-like protein subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_649566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069327.1">
        <property type="nucleotide sequence ID" value="XM_018212068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X588"/>
    <dbReference type="FunCoup" id="A0A194X588">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X588"/>
    <dbReference type="GeneID" id="28821794"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649566"/>
    <dbReference type="InParanoid" id="A0A194X588"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="49608" checksum="011F213F8F7DED3C" modified="2016-10-05" version="1">MRIRSTRASMLLKRTPTSTSQLFSTCSRCQLAARRPQLPIATTLCRHPARRRQSAWAQAVSVASNVFSNATSRAASDGNISVDPLRMVAKELKFLTGNIRQLLGSGHPSLDTVAKYYTQAEGKHVRPLIVLLMSRATSLSPKAARYGGQQSATDIDNAISPLSILSDVNPSTPSTNPIAHTQTSYPVGDSEILPSQRRLAEITELIHTASLLHDDVIDHSVSRRGAPSANLEFGNKMAVLAGDFLLSRASVALARLRDAEVTELLATVIANLVEGEFMQLKNTARDEKNPVWTEDAITYYLQKTYLKSASLISKSCRAAALLGSADVPTVDAAYLYGKNLGLAFQLVDDMLDYTISEKELGKPAGADLELGLATAPLLFAWKHNQELGSLVGRKFSQEGDVARARELVLQSDGLEQTRALAEEYANRAINSISSFPDCEAKEGLIDMAIKTLKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5M6</accession>
    <name>A0A194X5M6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_720013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069831.1">
        <property type="nucleotide sequence ID" value="XM_018218537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5M6"/>
    <dbReference type="GeneID" id="28828263"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720013"/>
    <dbReference type="InParanoid" id="A0A194X5M6"/>
    <dbReference type="OrthoDB" id="3555022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="717" mass="79484" checksum="AD4CF4E3F4A49FBC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5Z6</accession>
    <name>A0A194X5Z6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_686017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069582.1">
        <property type="nucleotide sequence ID" value="XM_018215188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5Z6"/>
    <dbReference type="STRING" id="149040.A0A194X5Z6"/>
    <dbReference type="GeneID" id="28824914"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686017"/>
    <dbReference type="InParanoid" id="A0A194X5Z6"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="237" mass="26399" checksum="70072B40AFCBB4A4" modified="2016-10-05" version="1">MLDHFTIKPGAGFPDHPHRGQETITYLLEGAVDHEDFAGNAGTIKAGDLQFMTAGRGIMHAEMPRQNPDDSANVGMQLWVDLPEKLKKCEPRYRDLRAKEIPSVDVDDGKVHIKVISGQSHGVDSVKELAYTPVWIMDIEIKPGGKVVQNLPEGWNAFAYTLSGSTAFGVGKDKTIVGQYHNVVFEQKGDEVVAEVEEEAKENEHFTLCHVAPLFLYWPSHFSVTCKLQYGNWECGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X778</accession>
    <name>A0A194X778_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_719400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070027.1">
        <property type="nucleotide sequence ID" value="XM_018218493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X778"/>
    <dbReference type="FunCoup" id="A0A194X778">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X778"/>
    <dbReference type="GeneID" id="28828219"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719400"/>
    <dbReference type="InParanoid" id="A0A194X778"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="584"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ15672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="641" mass="71186" checksum="03F2D70F6AB10865" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X790</accession>
    <name>A0A194X790_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_101906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070395.1">
        <property type="nucleotide sequence ID" value="XM_018205010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X790"/>
    <dbReference type="GeneID" id="28814736"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_101906"/>
    <dbReference type="InParanoid" id="A0A194X790"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="164" mass="19803" checksum="06C5596BBAF4511E" modified="2016-10-05" version="1">MPQHCNTCSHRCRCSPYNSTLHFLLYDNNPEMERYCYDDPDWPSTDSDRIFFFVLVILKILKLICAVVILVQKEIEEDERRSNVETRYEYLLEDLGRVERRRKKKKNKPESGKTKSVQKNDIVDRGIKRRPIGILKTRKRMRKIKVESWMQRCRSQQDHVTKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Z6</accession>
    <name>A0A194X7Z6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_78982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070640.1">
        <property type="nucleotide sequence ID" value="XM_018223300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Z6"/>
    <dbReference type="GeneID" id="28833026"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_78982"/>
    <dbReference type="InParanoid" id="A0A194X7Z6"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="10846" checksum="12845228F81D0525" modified="2016-10-05" version="1">MGSQLVVPECYICKSKAVVQITIQITKTPHNPYAWLERAPLLLYLGYPESGAGDARKAQRLATAILNMDEIGILAKKETCELVASTDCAITASFQNFGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X862</accession>
    <name>A0A194X862_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_586765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070659.1">
        <property type="nucleotide sequence ID" value="XM_018209386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X862"/>
    <dbReference type="FunCoup" id="A0A194X862">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X862"/>
    <dbReference type="GeneID" id="28819112"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586765"/>
    <dbReference type="InParanoid" id="A0A194X862"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="SPB4-like_CTE"/>
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        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="285"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="515"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ16304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="877" mass="96456" checksum="06C9FA7CBD3FB2FB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8W1</accession>
    <name>A0A194X8W1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_707780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28827363"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
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        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
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            <begin position="346"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="48322" checksum="4CC20BC536FFA253" modified="2016-10-05" version="1">MRWEEEAYSRTDSDDNPLSLIEYWNGGYPPLLRGAVNAASNIGNIIGQISFGFLGDTFGRKFVYGKELIICIIGTILVISLPNSIPTPTLKMVWIFCFRLLMGIGIGGNYPMSASIVSERSHFHTRGRMLAWIFSNQGWGTFTGSVATIIIVSCFRKAIKDEDQYNQLDAVWRIQMGIALVPAFATLIPRLRMPKEGNTPLQTFVAGGKAVLAKPKTLPAVPTGDTDLENLAKPQSRRAQLNTFFVYFSEWRHLKTFIGTASCWFLLDVAFHGTNLNQSVLLADIGFATGATHYDVLMRNAIGNLIIAVAGYLGRKWIQIQGFLMCALMFAILAGGYMHLSTAGKFTCFAIAQFFFNFGPNATTFIIPAEVYPSRVRGFAHGLSAATGKLGAILSALLFNYLAGSIITWFLIPETKGRDADVIDFEEWQEKNGIEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X931</accession>
    <name>A0A194X931_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_747811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071035.1">
        <property type="nucleotide sequence ID" value="XM_018221138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X931"/>
    <dbReference type="STRING" id="149040.A0A194X931"/>
    <dbReference type="GeneID" id="28830864"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_747811"/>
    <dbReference type="InParanoid" id="A0A194X931"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="17652" checksum="842FCE43A800DE3D" modified="2016-10-05" version="1">MDEGQKDASTTSLGRGKGTSSLGNLTFVGLRSADFFLQLYLLRQYPLITSGSSFLGLTPYYAIVASLALITSVRHDFWKLYTSDQKASVSFAITVSAFNTIFNSLNIATSLWSITSNAPAIEQGMFASSSRSLGLGLFILGSFCETFTELQRKAFKDNPNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9Z0</accession>
    <name>A0A194X9Z0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_68160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071304.1">
        <property type="nucleotide sequence ID" value="XM_018214331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9Z0"/>
    <dbReference type="STRING" id="149040.A0A194X9Z0"/>
    <dbReference type="GeneID" id="28824057"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_68160"/>
    <dbReference type="InParanoid" id="A0A194X9Z0"/>
    <dbReference type="OrthoDB" id="70316at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="180" mass="19504" checksum="A6EE07503EBD7E16" modified="2016-10-05" version="1">MQCLPSTASPETPTPTTVIDSASASGPGTTLQSGYLWIRAVESPNFHKYLQSRPLYSPGQAILDTYTTAGQFQIISGQLVQLLNSTSFLYANVQRNTSAAVKLSVSFNTTKNAYGTFVFSGDAVTWSTPDISRPNLSAWLVCGEKSLWINLGNYDYMTPSGCVDETIHFYNAATPTPRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAV9</accession>
    <name>A0A194XAV9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_684372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071639.1">
        <property type="nucleotide sequence ID" value="XM_018214868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAV9"/>
    <dbReference type="GeneID" id="28824594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684372"/>
    <dbReference type="InParanoid" id="A0A194XAV9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="26413" checksum="706EF6A64495E28E" modified="2016-10-05" version="1">MSLSRSVDRYAAQQTLSVSSLSSSPTSHTDHARTYPLKQTNKPHYNAFSEPPLSTSVPLPISKGLNEKERRPVTRKPVPQSSAGPETDDNTSVGSRYDTNEVYNEISIARSEAERYQNTLKNNPMKLNKTANPSSIIPTSRSRTLHDDSTPQPSKETKRKTSFDSFSFHTGDEAFFSIRRRGRTPEPKKDTESEHSFESFHAGDEDAFQAHLTRSAILARMGRREEKRWGCCFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBU7</accession>
    <name>A0A194XBU7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_585462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071582.1">
        <property type="nucleotide sequence ID" value="XM_018209321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBU7"/>
    <dbReference type="GeneID" id="28819047"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585462"/>
    <dbReference type="InParanoid" id="A0A194XBU7"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="56951" checksum="6D8397F080BDBE2B" modified="2016-10-05" version="1">MSIYSSPPPARTFHDDKATLLVCWWCTIFAAVIILFRVCGRYIRTEKLFREDWLAFACLIPLFIRMAFVHVILLFGTNNAITTGLSDEDIWRRSIGSRLVLVSRIFYAATLWMLKLTISEFFKRLTLNIWTRSHERVLMGIRWFLLVTFVAVVIADLSECQPFDHYWQVTPDPGPKCRQGYAQMLTMGTSDVITDILLVAFPIPIIIRSKMGVKRKIQLVFLFAGSLLPAGTTLYRIPNILDRHGSQQYRSLLASIEILFAVAVANALVLGSFVRDRGVKKQRWKFGSMSDSIERTSSRRGTAIRHWGSDEDLVRDLGISVDPELRDPEAATFRPAPMAVAGNVPVKAHKIMGRDWQFPGERSDTSDEMDLMKIGEAHSPADVSSVITPRRVSFFDVGGLLDEDHPPRRHSSTKTMDTEGETSSFGGLQSVHSKNDDAGLSPTPARRGSAALLQDVGGLLGPKPKKAPPYRGYELQTIHQERSSPSLGPRISRQQTTHSLQDVGGLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC62</accession>
    <name>A0A194XC62_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072110.1">
        <property type="nucleotide sequence ID" value="XM_018214932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC62"/>
    <dbReference type="GeneID" id="28824658"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684702"/>
    <dbReference type="InParanoid" id="A0A194XC62"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="341" mass="39060" checksum="8E77F23E5043363D" modified="2016-10-05" version="1">MLACDRDWYFLDRDSVCSQSPWFARIIPKYSRTLADISGFAVTCFAVEYVQNDIFQYVVSFLETGQYPPNGLLSREPWMYLLQHVRVYSLALRFQLKALESLASVAFQNGIVDCRPDLLDHYIDNLHLMSTLCGPDPKNNIIYPPRQSALKGCAAYVMVRLSGDLLDNANFRDACRDDSNFRVFLRAVAFDKRLKASRRGKLLQTFLKNAGARDRSTVVSTQERQTLTITAPTDGCGVNLTASMPLARNNHFRSLKEEVRDNSNNTNPFRRHTIDVSTFKLGPQTEATMLLSSGRSETWYPANLSSFYPNKFPLFIAHPIEERKHIFWSLMTSRWPEKPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCQ3</accession>
    <name>A0A194XCQ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_583531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072305.1">
        <property type="nucleotide sequence ID" value="XM_018209219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCQ3"/>
    <dbReference type="STRING" id="149040.A0A194XCQ3"/>
    <dbReference type="GeneID" id="28818945"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583531"/>
    <dbReference type="InParanoid" id="A0A194XCQ3"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="383" mass="42262" checksum="D03089029CC0E0F3" modified="2016-10-05" version="1">MHPQEVLGSHKRHDFIDSSIFGRRLDTSSVQLPETLPPSYRAGDFDDNDLYQGINTFAHLDFIECMKPVSSGSFDIGIVGHPFDLGVSYRPGARFGPNGARQGARRMSPSAGWDIDHDLNPYQDWAKVVDCGDIGNNPFDKLVAIHQLEKGMQAINNVKAANDSASEAVRLITIGGDHTITLPILRALHSTWGRVAVLHFDSHLDTWDPKQLGGGLTKYSEVNHGTMLHIAHEEGLLSNHSNMHLGSRCTIFDEHYDLNNDLRCGFTYIRARELDKLGVDKVVKKIVERVGDEYVYLSVDIDVLDPAFAPATGTIEPGGWTTRELQQIINGLSDAGLKIVGSDVVEFTPIYDNAAETTAIALAQIVYEVLQWMVHVPVKSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCQ7</accession>
    <name>A0A194XCQ7_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_732657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17955.1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268098" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15115" checksum="4A39AA1892924218" modified="2016-10-05" version="1">MHLLTQYLFIIALSGHALAAPAAPNLDARAVNARGDSLIEAIFVEGDVVDAEPKLKRGDALIEDIFVEGAVVEAAPKLKRGDSLIEQIFVEGEVVETETKLKRGDSLIEQIFVEGDVVGKAKRGDVLIGRILDEGAVVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCR1</accession>
    <name>A0A194XCR1_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein AAED1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_583519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17941.1"/>
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    <dbReference type="GeneID" id="28818944"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583519"/>
    <dbReference type="InParanoid" id="A0A194XCR1"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36922" checksum="08D6473105102BA6" modified="2016-10-05" version="1">MPTAHPEEHTADSSHSKSSLETADTAVNASDSEPIEVEFVGDVKTDNKLPSLKTLKKIENLPVLDQDGKAIPFKNLYTGPNVARRVLIIFIRHFFCGNCQEYIRTLTSSISTSSLLSLPTPTFIAIIGHGDPSLIPMYQRETSCPFPIYADPTKKLYSELGMTRTLNLGSRPEYQRKELFSIMLDGFVQSLKMLRGGRALKGGDYHQVGGEFLFEPVEMESPSPLSSPEEQTKRLGEQGMLEMGAVEEKHVTWCHRMRNTRDHAEIPEVREVLGLGDGEELPKGVNEKRWRAALLVRKGTGLSTVSTEGRPSVGLSRKLQELEDDGAGLKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCW0</accession>
    <name>A0A194XCW0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_57815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071947.1">
        <property type="nucleotide sequence ID" value="XM_018208930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCW0"/>
    <dbReference type="GeneID" id="28818656"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_57815"/>
    <dbReference type="InParanoid" id="A0A194XCW0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11606" checksum="AEF9438918FA3C49" modified="2016-10-05" version="1">MDTNKDFVWQLYQLTHCLNLIFPPHCCPPRYPSHCNTIVLTWLTKWKGGEEYWKGGGYKEIFQPQLSFHTSIILFAFTHLGSLLLVHLPSLWHWGEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEE6</accession>
    <name>A0A194XEE6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_582628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072903.1">
        <property type="nucleotide sequence ID" value="XM_018209174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEE6"/>
    <dbReference type="GeneID" id="28818900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582628"/>
    <dbReference type="InParanoid" id="A0A194XEE6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="80" mass="8639" checksum="D09993E0A9056CE6" modified="2016-10-05" version="1" fragment="single">QVGGMISIVCSPNSTWMIGSLVGASEGVMYEQLPRAQVEKASKHSKPSRAECPASKVREVAFHVVTTHLSKCIDKPRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFB9</accession>
    <name>A0A194XFB9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_706460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073184.1">
        <property type="nucleotide sequence ID" value="XM_018217529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFB9"/>
    <dbReference type="GeneID" id="28827255"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706460"/>
    <dbReference type="InParanoid" id="A0A194XFB9"/>
    <dbReference type="OrthoDB" id="5311240at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="604" mass="66748" checksum="9CD04EC18F9AA31A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG87</accession>
    <name>A0A194XG87_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_706434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073147.1">
        <property type="nucleotide sequence ID" value="XM_018217526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG87"/>
    <dbReference type="STRING" id="149040.A0A194XG87"/>
    <dbReference type="GeneID" id="28827252"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706434"/>
    <dbReference type="InParanoid" id="A0A194XG87"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268206" description="Cytochrome b5 heme-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ18792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="344" mass="36997" checksum="BD3124D4C7FA8964" modified="2016-10-05" version="1">MLLGISILVASVSYLCYRHPPSSWSILSWLIRPSIQEISTKKEADAPAAPRHNNDDPSTPKMIPLLQEEKIPVLATTMTIDTDKQASDRKAMPPPPLPISNAAPPPPPPTFTLNNNDSSSSSDEEQENTLPPPSFPALNSAQRASAPSSRGPPRLNPLPTTGLMLPPPRPSSSSLPNRNPPSLKTATTTLSPPPTHTQPPLKPRKKVLLTPGHSPLDWARLSSSPTANLRGLPLSTPYLKVPPSLLSLHNGKFVKPPSFSVDGERVRNDAWTVLGGKVYNITPYLPYHPGGEGELLRCAGRDGTRLFGEVHPWVNWEGMLEGCLVGVAVTEEDVVGGGGLEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGE1</accession>
    <name>A0A194XGE1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_773421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073588.1">
        <property type="nucleotide sequence ID" value="XM_018221933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGE1"/>
    <dbReference type="STRING" id="149040.A0A194XGE1"/>
    <dbReference type="GeneID" id="28831659"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773421"/>
    <dbReference type="InParanoid" id="A0A194XGE1"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="26628" checksum="BC2C7B62B096A164" modified="2016-10-05" version="1">MYWQEWLTALSVNSNVIAILEPTDGYQTFTLNTTNNITRVLINNPPINLLDASMLADFHTLLTGPASNLDGPKAIIFSSANPEYFIAHLDIHILSSDHPVPPPLNNTELSNLYVNVTRLLATVPAILIAEVSGQAIAAGNEMIVQMDMRFASPGARLGAAEVGVGLTHAAGGLQHLTRLIGPGRAAEYLLGIIDADLDTLADIGWVNSAFESAAEMQAHVDALASRIALWPRGGLVATKQGIREGGWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHB8</accession>
    <name>A0A194XHB8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GTPase CDC42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_731930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073891.1">
        <property type="nucleotide sequence ID" value="XM_018219630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHB8"/>
    <dbReference type="FunCoup" id="A0A194XHB8">
        <property type="interactions" value="932"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XHB8"/>
    <dbReference type="GeneID" id="28829356"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731930"/>
    <dbReference type="InParanoid" id="A0A194XHB8"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ19536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="194" mass="21583" checksum="BEDC7086248188E0" modified="2016-10-05" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQTDLREDPSVREKLGKQKMSPVKKEDGERMAKELGAVKYVECSALTQYKLKDVFDEAIVAALEPPAPKKKHSKCMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIJ0</accession>
    <name>A0A194XIJ0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_641384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074333.1">
        <property type="nucleotide sequence ID" value="XM_018211711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIJ0"/>
    <dbReference type="FunCoup" id="A0A194XIJ0">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIJ0"/>
    <dbReference type="GeneID" id="28821437"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_641384"/>
    <dbReference type="InParanoid" id="A0A194XIJ0"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="390" mass="44401" checksum="A4A8C6C2DC0521AB" modified="2016-10-05" version="1">MSSTFEIQPIGRFVGQSAAIKRPKEIACFSYDDQHQFRLDDSSIKWYYPPTLGADLSRGFDTFQKMDDTADDHLDSLLKTIINYEQKEGKRVETDFITWRGMMTKIMGAIFSDRDGFEMNATLFQDTIFIEEHHAYKLQSHARQSAQASQPGRPSQDMMSFWGYKFETLCLLPKTWAETPRDYIENRENEVVSNHAQYCSIVRTSIGNSVLILGGEVDAIWDSKPTDGSPIHWVELKTTADIRNDRDMVNLERKLMKFWIQSFLLGVPKIIVGFRTPDGFLKRVEEMNTASIPGTVKRSGKATWDGNMCINFAAALLDFIKATVTGDGVWRIRRKERSPTIEIFKSEETGHGDILSDEFINWRIKLALNSKQTESLNAGASSTAMDVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIJ5</accession>
    <name>A0A194XIJ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low temperature viability protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIJ5"/>
    <dbReference type="FunCoup" id="A0A194XIJ5">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIJ5"/>
    <dbReference type="GeneID" id="28824295"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682778"/>
    <dbReference type="InParanoid" id="A0A194XIJ5"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="45785" checksum="23FFC1F14BAEFE90" modified="2016-10-05" version="1">MARKGWIDKKTATHFTLVHRPQNDPLIHDESASSMVLNPTPLPNSNKVKKLDDLASELGLDAEQIRENEGEAANYGIYYDDTEYDYMQHMRDLGTGDGEAYFVEASAPKNKGKGKGKQSLEDALKNTSLEDRDTALLDEDILPSKNLRRVTYQAQQDVPDALAGFQPDMDPRLREVLEALEDEAYVDEEDDVFGELAKDGEEIDEYEFEQNAFEEDEGWESDETEKPAKEYKDAPVPTADLVNDEREDHGDGAWMEDFSKFKREQKSKVSPAALSQSDLQSSLITTTTNGGRKKKRKGALTNPSSYSMTSSSMFRTEGLTMLDARFEKIEEQYNEDVDDIASVSAASSTASSVQGPMRGDFDNIMDDFLGNYSMSGKKHVKKGKYQSGMEQLDEVRKGLGPARIRTQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ00</accession>
    <name>A0A194XJ00_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_731450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074580.1">
        <property type="nucleotide sequence ID" value="XM_018219572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ00"/>
    <dbReference type="GeneID" id="28829298"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731450"/>
    <dbReference type="InParanoid" id="A0A194XJ00"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="56250" checksum="2FF1013CBA920DE2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ31</accession>
    <name>A0A194XJ31_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_716277</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074117.1">
        <property type="nucleotide sequence ID" value="XM_018218259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ31"/>
    <dbReference type="GeneID" id="28827985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716277"/>
    <dbReference type="InParanoid" id="A0A194XJ31"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268305" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="645"/>
        </location>
    </feature>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <location>
            <position position="592"/>
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        </ligand>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
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    <sequence length="645" mass="71145" checksum="562718EA63E1767E" modified="2016-10-05" version="1"> </sequence>
</entry>
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    <accession>A0A194XJI3</accession>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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</entry>
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        <lineage>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <location>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="358" mass="40142" checksum="809A1C10CCEB1D17" modified="2016-10-05" version="1">MLQGAHVFSHQQQFNPHGEPAWMHQQSHHQHAQQAAAAAASAAQQQHYNRIAANHNSNAPSIVSNHGQDALMENVSEDNRKTLVWISELLREETRESALLELSKKREQVPELALILWHSFGVMTSLLQEIISVYTLLNPSQLTAAASNRVCNALALLQCVASHNETRALFLHAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNDSSDVINFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDHGLNYICATYERFYAVGTVLSNMVTQLVEQQTARLLKHVVRCFLRLSDNARAREALRQCLPEPLRDATFSSVLRDDAATKRCLAQLLINLSDNVVDSQSQHQQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKP1</accession>
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        <submittedName>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKP1"/>
    <dbReference type="GeneID" id="28818686"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578692"/>
    <dbReference type="InParanoid" id="A0A194XKP1"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="30763" checksum="759EBC8A49D4155C" modified="2016-10-05" version="1">MPRSATDATRFTSTTPYASAKPPPSAQKSKGPVGETPQEKIRRLRAAADRARDAQVTTFDKIVIRGRVWADRAHRFTALSLIGATFVAGGVTVYTFWDMIVYNRKKRAQFYQEQKAKQQSAVHDAREAIAAGTATEAQINFIKMEDDYQSKVDAAKKKKAEPGPVRKARDWLFEGLKKEEQGKDVGTSERRLGYEALSEEDDSMGERESDIVRALEDKKIAITEKAKHAFAQERHLERTGGPLDRIGTATETSVVVASATQDQPKSKSWSSWIMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLM8</accession>
    <name>A0A194XLM8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_729946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075505.1">
        <property type="nucleotide sequence ID" value="XM_018219421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLM8"/>
    <dbReference type="GeneID" id="28829147"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729946"/>
    <dbReference type="InParanoid" id="A0A194XLM8"/>
    <dbReference type="OrthoDB" id="5313995at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="17990" checksum="476505DD5FC69419" modified="2016-10-05" version="1">MPPPSFKLPAYYTAFFLFIEPVSALVGAFYAHFRPLEYLRLTHASSAPAYAATIPLSTSTVLDQLSNLYLLFAINEALVLRSTSDLRVWRTVLLGLLIADFGHLYSVRHLGTDIYWNALKWNKMDWGNVGFVYAGATMRMLFLAGFGMNSASGKKAAVKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLP3</accession>
    <name>A0A194XLP3_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_563477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075042.1">
        <property type="nucleotide sequence ID" value="XM_018208496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLP3"/>
    <dbReference type="GeneID" id="28818222"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_563477"/>
    <dbReference type="InParanoid" id="A0A194XLP3"/>
    <dbReference type="OrthoDB" id="5420958at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="78" mass="9015" checksum="7AA8F661731F7694" modified="2016-10-05" version="1" fragment="single">IDRASQVLTQGVPLGVPRSYRALADHGNKARGQQYLEPYEEDVVVKYLLQMSDLDQPIRIKFIPFIAFRVTYHRPITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLW1</accession>
    <name>A0A194XLW1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_428384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075523.1">
        <property type="nucleotide sequence ID" value="XM_018207456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLW1"/>
    <dbReference type="GeneID" id="28817182"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_428384"/>
    <dbReference type="InParanoid" id="A0A194XLW1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="155" mass="17316" checksum="EB060E8D24DF8485" modified="2016-10-05" version="1">MTIGLQKIRYAGSGRRSCWDHSECPLPFAQQQVTAYPASTLHHVESHPTSHQPGNAPASCTCISNQRFSIRLQIPKSEMFWAASGPHSLRPGKAAGPVPRCSRTRVDRYHDLVEGTDYLMLKAFSLESKAESMATREMSRSFYSSDNQKMGKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNI0</accession>
    <name>A0A194XNI0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_730091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075662.1">
        <property type="nucleotide sequence ID" value="XM_018219439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNI0"/>
    <dbReference type="GeneID" id="28829165"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730091"/>
    <dbReference type="InParanoid" id="A0A194XNI0"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11494" checksum="8D173EE81A7BA822" modified="2016-10-05" version="1">MADRVSDLIVDSKLDVEVHADYTIHKIFHSDPTIGRRRIKIDERWQKSRELGRGAVGVVWLESCSAGPHMGQLRAVKEIRSGGRDAYTKYLRELEAIAKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNN6</accession>
    <name>A0A194XNN6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075697.1">
        <property type="nucleotide sequence ID" value="XM_018214390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNN6"/>
    <dbReference type="GeneID" id="28824116"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681878"/>
    <dbReference type="InParanoid" id="A0A194XNN6"/>
    <dbReference type="OrthoDB" id="5398130at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268490" evidence="1">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14740" checksum="1EE80455A070B12F" modified="2016-10-05" version="1">MRSVSIVTLAYLAAFFSGSLAAPTPDNPKFDWPGLLNEVEKRDNPKFDWPGLLNEVEKRDNPKFDWPGLLNEVEKRDNPKFDWPDLMEEVKKRDNPKFDWPGLLEEVKKRDNPKFDWPGLANEAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPE1</accession>
    <name>A0A194XPE1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosaminyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_576767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076294.1">
        <property type="nucleotide sequence ID" value="XM_018208853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPE1"/>
    <dbReference type="STRING" id="149040.A0A194XPE1"/>
    <dbReference type="GeneID" id="28818579"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576767"/>
    <dbReference type="InParanoid" id="A0A194XPE1"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="208"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ21939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="496" mass="57224" checksum="B8AA4CF08D2140B5" modified="2016-10-05" version="1">MSIFDDALEPITKQSRFQHLLTSFQRSLVDVSAFITEWTPFLLVASYYWFSICLYILFPPWIMAIFWYIYMISNFYIASSTVLEAFMSLAPIRDARKTISKAQANEWRFPTPDSDLPILDLLIVAYLPNEKDIIMDRALYALEKIAYPQHLIRINILYNTPRSIEPLESQLHDLTKKYSHARVIKVPGSTSKADNLNYFFSLDTGSDIIAIFDCDHYPHPNNPRWAAERFMSDSAIDIVQGRCVIFNAPASLLAAMISVEFDKIYAVSHPGRSSMWGFGLFCGSNGFWRTSLLRRLKMDGSMLTEDIDSALRAVSEGAKTVHDMNVVSYELAPTQWPAFWKQRLRWAQGWAQASSRHLIMSFTKPAEGVRKREFRTRFGLFSLLLIREWSYYLVTQYTCLVVSMVITDFPKTAGQLARLIFFQFPLSEWFFIISLLCLIATLYITNRVRSEFVERWMIVAFSVIYPFYLVLAATIGLYGHARAVTKYSAWNPTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPH0</accession>
    <name>A0A194XPH0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_392899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076416.1">
        <property type="nucleotide sequence ID" value="XM_018207204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPH0"/>
    <dbReference type="GeneID" id="28816930"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_392899"/>
    <dbReference type="InParanoid" id="A0A194XPH0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="14299" checksum="F5DD8C6B0A1C7B0B" modified="2016-10-05" version="1">MDDCSLRYLLICIHGCQSTVILMCIHASKTICQYNALYRTFFFPYDFTHFHGLFSYSCILNGSRLAIPRTLTKRRVLLFLYAFTYVHALFSCYIFMLVKRLFFSYVCTPCHALSHYIFKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPR0</accession>
    <name>A0A194XPR0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_636049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076595.1">
        <property type="nucleotide sequence ID" value="XM_018211474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPR0"/>
    <dbReference type="STRING" id="149040.A0A194XPR0"/>
    <dbReference type="GeneID" id="28821200"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636049"/>
    <dbReference type="InParanoid" id="A0A194XPR0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011114324" description="pectinesterase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="167"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="398" mass="43008" checksum="19F190EFE8059345" modified="2016-10-05" version="1">MYLRRSLGYLLTSTFFLANLAHANNSTSAYVACQAVTVNPLDGCPSNTVLVSQTDCSANFSTIQSAVLSIPNNTIPYTILVLPGNYIEQINVTRSGPLTILGQTNSPNDQSENSVTVYWTSADANSDLPGDAFSSVLTVAPNLNASLTGSGPTGFAVPADTPFGCTDFRVYNIDFRNVYSEISAGPALAVSVSRANAGFYYSGIYSYQDTVYVGKLGNAYFYHNEIAGQTDFFYGFGTAWIESTSVLLRGCGGGITAWKGTNTTFVNKYGVYISDSTLNAANSSIAPSMVGKCFLGRPWNALMRAVYLNMYMDASIAPAGFKKWTTDPATDNYGPNTTMAEYKSYGPGFNLTTRIAGNLTIEFTADQARAYRTPKDVFMASDGSQSYYSWIDAAYYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ31</accession>
    <name>A0A194XQ31_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_694323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076207.1">
        <property type="nucleotide sequence ID" value="XM_018216697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ31"/>
    <dbReference type="STRING" id="149040.A0A194XQ31"/>
    <dbReference type="GeneID" id="28826423"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694323"/>
    <dbReference type="InParanoid" id="A0A194XQ31"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268522" evidence="9">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="41197" checksum="47FE81B41A6B77AB" modified="2016-10-05" version="1">MQRESISIIFLLFGLRMFHILHPENVKMVLFENFDDYGFGDRRAVFAPFLGSGGVVDLQPLFFNLTLDTTMAMLLGKLVYSLRIDNGNEDSNRAFVESFITAQESLVKRFRIAFFYFLYAFLSFRRVCSTTHRFVEDYIHERNLQSSEAGELYGFIDKLAQKCGTTAELRDQLLNVLLAGRDTTACCLSWIVRFLVRHSEVMDRVRTEIVSVLGKMWYLAFIIKESMKIFRLRLYPLVPLNNKTAMRITILPTSSRPNRKSPILVKRGKVVIMSQYEIDELKDIGWAYFPFNGGPRACLGEDFAIMEVLYTIVRLLQSFPLVKLPVGEKNEVVGSEKQRLTLVLSSADGCRVNLGQSIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQH7</accession>
    <name>A0A194XQH7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_728654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076875.1">
        <property type="nucleotide sequence ID" value="XM_018219285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQH7"/>
    <dbReference type="STRING" id="149040.A0A194XQH7"/>
    <dbReference type="GeneID" id="28829011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728654"/>
    <dbReference type="InParanoid" id="A0A194XQH7"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="110"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="40792" checksum="50E4D0F6AC1EEA35" modified="2016-10-05" version="1">MAPKHGLAGLQSEEQLAKRAKSSATPASRSATPADTSAKVPFKVEYPIMDSEKIQTDRQKELMDAADFQVSPFVAKGASKEGELDQYYTVTPTNEWEQMKKYNNFIIQGEVYKNNQFVFVRGEDTPKDKDTEGRPKDFWVARILQVRAKNAQHVYALVAWLYWPEELPPPSVKASDQLGKESGKRRYHGSHELIASNYMDVLDVLSFAGKAEVHHWLEEDDNLQHKLYWRQTFCRETQALSKLRQHCTCKGYFNPEVTMYICDNPTCKIWLHDDHLLDDILTKVYKKHNSNDGTNGVAKINGKKSKNPPYKNAFKATIREENDEPPVAVITDLRPNADPKTWEERIACPECEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS25</accession>
    <name>A0A194XS25_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077301.1">
        <property type="nucleotide sequence ID" value="XM_018219190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS25"/>
    <dbReference type="GeneID" id="28828916"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727735"/>
    <dbReference type="InParanoid" id="A0A194XS25"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="137" mass="14869" checksum="CFA449A5CD0A0096" modified="2016-10-05" version="1">MSGSGGYYKYRCKYWLTYNCPHWVWVNGAPCAHCLADGRDSDVTTMPGSFRISREVYVPQLENGSLHYTIMEIIAASDFDSGWAVKDLPTQAFPTATGPSAVNLTAMERVDAPRNPKSGFQAPADGGSWPGSGVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSK1</accession>
    <name>A0A194XSK1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_573869</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSV3</accession>
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</entry>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7073" checksum="5AFC2306AC0668CC" modified="2016-10-05" version="1">MYQGVNPTICEFCGHRMGNGIAPNRHCIPRHSIKFVEEKDKHQYENSEEPCPWVNNRCRD</sequence>
</entry>
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    <accession>A0A194XUQ8</accession>
    <name>A0A194XUQ8_MOLSC</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="154"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ23943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57314" checksum="5ECC748987AFF055" modified="2016-10-05" version="1">MDGLSAAASIIAVIQIAQIVGSELKDYYEGVRQAREEIQKLYNTIKNLEVILERLQELFQLPSSHLSVVDPVFVDQAGPLKQCQEELSKLEAALEISTHRGRIRKSVQSLKWPFEKKDVEKRVVVLERHKSSLALCIGVENLQSFGESLIYYGSTVIDHIQKRSINESNVAVVYWYFTFTNIDKQNVANALCSAIADICGNRRDTPEELQRAHDRCNAGQQKPPFDVLKSMLKVVSNGFDNIYLILDALDECPTTDGQRDTLLEFLHEVSSWQLDCLHVLATSRRELDIQESLTSSHGKSSHFLSVQGSHVEQDIMKYLGHRLEHHTFRSWKPALKQDVKEDLVKKANGMQIREAMNALPRSREALYNRMLQSITDEDQEYAQRAFQWLAFSARPITLEELAEAAIIKPCAERPELLEETRFLDPQDLLHIIPSGLISVITINPYDFDNSMSEEDMIKYIDTLFGDNESMSASANYPSGSDDFHSGDDSSEFVFEAGDLEDPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVC3</accession>
    <name>A0A194XVC3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078319.1">
        <property type="nucleotide sequence ID" value="XM_018219111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVC3"/>
    <dbReference type="GeneID" id="28828837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727016"/>
    <dbReference type="InParanoid" id="A0A194XVC3"/>
    <dbReference type="OrthoDB" id="3533338at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268711" evidence="1">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="32885" checksum="76586827AB4BAE20" modified="2016-10-05" version="1">MSFTPHLSSLQVLLVPVLLSLFISSSSAVETVTAIVDTPYTDYLDFQQFVLIASGPTPTDDDFASISSTAFPLATASCSSYDVGATVELVEALADIFCTGLDLSEGSSVFQTADICALGCNSSYTQIITSCEFNSQLIYGSGSLQDTCGTFAISLSSAVLAPTSSTTFAPPPPSPTPTLSPPGLQDQECYEADSFGKHSDIAGKVQSSYATTFCSTNDQTFTSGTAPVLWNAGSIIFRDGLTPYHYTVSWLDGCMTTATQQSMDQPLAGDSTVTCVSLVKENWRNCNNGGAGGTRIAGCLKYNFAATLNTTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW46</accession>
    <name>A0A194XW46_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_745436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078880.1">
        <property type="nucleotide sequence ID" value="XM_018221067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW46"/>
    <dbReference type="GeneID" id="28830793"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_745436"/>
    <dbReference type="InParanoid" id="A0A194XW46"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="57832" checksum="EB3057137C5905E6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWH1</accession>
    <name>A0A194XWH1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_24902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078933.1">
        <property type="nucleotide sequence ID" value="XM_018206171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWH1"/>
    <dbReference type="FunCoup" id="A0A194XWH1">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="GeneID" id="28815897"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_24902"/>
    <dbReference type="InParanoid" id="A0A194XWH1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="13831" checksum="1D1C2F12BABF4870" modified="2016-10-05" version="1">MVMKEAVKTDKAPPPMPFLSQAIKCGGMVYCSGSVGMDPTTSKLVEGSVADRTEQCLKNLAAVLEAAGSSIDNAVKVNVFLINMDNFAAMNKVYEKFFHKDPKPCRTCVAVHQLPLGTDVEIELTAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXW7</accession>
    <name>A0A194XXW7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_663397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079032.1">
        <property type="nucleotide sequence ID" value="XM_018212702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXW7"/>
    <dbReference type="GeneID" id="28822428"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663397"/>
    <dbReference type="InParanoid" id="A0A194XXW7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ24677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="505" mass="55631" checksum="1B0A403CE9721428" modified="2016-10-05" version="1">MASLGVLRESDDFELSLALQNNSALQRALQEGGKTDETRQSLIVLACRTIQSCLGPGVKLDPDPSLANTNWSQSCWLTPKCIVYPRSAKDVSRTIKILGLLHTPFSVRCGGLSPTPEHSSIADGVLIDLRELGGIEISADGRIASVGPGARWSDVFEALDPHGLTVVGPRLPNVGIGGFILGGGLSFFSGEYGLAADKVENFEIVLSDGLIVDANSAEHPDLFWALKGGGSNFGIVTRFDLSTVPIRDIWYSMSTYAITEVPEVLLAFEQWQLRSADPKSAIFLRMGLDSCTITLVYSSPAKRPPCFNVFYDIDVMEYLILPTNGTVVSLTTALAELFPHNPARHDHRAASRKNDLGLYSAVEAYWVWRKETLALRDSTRADATFMIQHVPKTLIEKGIEDGSNPLGLTAVPQQWWAIVVDWDSAKDDNLVRESLRDITKRWTDLAKEQGTHLDFEFMNNASGDQNPLRSYGETNLQRLRDISMKYDKAQVFQLLQKGGFLLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1M1</accession>
    <name>A0A132B1M1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_744011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060643.1">
        <property type="nucleotide sequence ID" value="XM_018221007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1M1"/>
    <dbReference type="STRING" id="149040.A0A132B1M1"/>
    <dbReference type="GeneID" id="28830733"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744011"/>
    <dbReference type="InParanoid" id="A0A132B1M1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287754" evidence="2">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24951" checksum="661D6FF271CA100C" modified="2016-05-11" version="1">MATTLQLRVLFFDVFGTCVAQRTPVADELWKATREALESDESSISSEVRTKAAEMEWNKEGEKFVRESNGTVDWRAVDKHRAELLPQLLVRHGLIIPHEDASTSEFQVGEGSLRDESQLKHLGLVWHRLTPWPDTCHGLDLLDRKLSTVTPSNSYNDLLEDLVARSNIPFTHIYSADMFRSFKPNPKVYLGAAEKMGVKPEEYLWELLIEENVFQFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Z3</accession>
    <name>A0A132B3Z3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_712334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061406.1">
        <property type="nucleotide sequence ID" value="XM_018217970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Z3"/>
    <dbReference type="GeneID" id="28827696"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712334"/>
    <dbReference type="InParanoid" id="A0A132B3Z3"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="540" mass="60432" checksum="9B62A5A71F0D5D45" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B448</accession>
    <name>A0A132B448_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_692312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061049.1">
        <property type="nucleotide sequence ID" value="XM_018216512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B448"/>
    <dbReference type="STRING" id="149040.A0A132B448"/>
    <dbReference type="GeneID" id="28826238"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692312"/>
    <dbReference type="InParanoid" id="A0A132B448"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="33363" checksum="5948B04D8D9C8FE8" modified="2016-05-11" version="1">MATIGIVSIGEMGLGIALLLKNYGYQVVTNASERSQSTRDRAQSVGVELLPDYVELVQRSDYILSIVPPRDAIKTAEFISTAASKSSRSEPVYYLDLNAVSPRTARHVATLFSSNSNIKFLDGGIIGGVPHRKASGKWHCPSLVISGPTRIPSEALNQHLRIHHLNDSIGAATGLKICFGMNTKGFTALAIQSFTTAHKLGVLPEMREYLKRDFPETLKAAEEGLTTMPPKAYRWVHEMLEMADTAAEDGGFEKNLFEGVSEVYRAVAEDSDLGLEKPGARVRGKTVEDVVTLLSEGMTAKKLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4F8</accession>
    <name>A0A132B4F8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_725813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061653.1">
        <property type="nucleotide sequence ID" value="XM_018219006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4F8"/>
    <dbReference type="STRING" id="149040.A0A132B4F8"/>
    <dbReference type="GeneID" id="28828732"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725813"/>
    <dbReference type="InParanoid" id="A0A132B4F8"/>
    <dbReference type="OrthoDB" id="4524534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287853" evidence="2">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="27669" checksum="E0ECA77DA9D54F13" modified="2016-05-11" version="1">MHSLLPLISLCGLTTSLSLPRSPASRTMIPSTSFDTQSDFDASWADLYPWGSDHNGGARMESSKIAISSGVLTLTASPASGEKPASSGGKSIPIHYLSGTVHAKQHFNVSRTGGYDFSAEFKATTTKGTWPAFWLTAVDGWPPEVDMAEWKGSGKVSFNTFNTSKEVEAKDVTYEDAGSWHSFKTEVRDENGRDLAITIYMDGKEVTRQVGKDFLGKPMYLIIDLQMEGSSGSPGPKDGPESGSSELQSLRKKIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4P5</accession>
    <name>A0A132B4P5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061656.1">
        <property type="nucleotide sequence ID" value="XM_018220898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4P5"/>
    <dbReference type="GeneID" id="28830624"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742943"/>
    <dbReference type="InParanoid" id="A0A132B4P5"/>
    <dbReference type="OrthoDB" id="10483213at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="364" mass="40324" checksum="BB4C61F75F2CFE63" modified="2016-05-11" version="1">MLASNNGLLPGHYSNTSLPVEHSASPNLGPLVTSAPTQYMLPPLSPESYSKLVAEGNPDVMFENYLNFDGYDQMDATTTAAQNSHAQSSLGQASPMDMTSHYGQTERLSPEPETSPAAAPASVPSSPGPSAAPVPAHQHAAVANHVHANGGANVHTATNVPAANVANPQASTNTDSLWPTICYFCKPDANGQHVLYYNWNEWLLHGWTVHPNVELWTARPCFWEETKNGVVEKCNNGVTYLTARQCIYHIFAVHKKSVHCDHADCEYGPTGKALGTRQDKVRHVQDMHEPAKTCQLPFCTHTKRRLNRTDHRKGHMRKYHGRHCCPVATCERARLEGDFYGFSTEEELQAHKQARRHRHARRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4S9</accession>
    <name>A0A132B4S9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_726349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061032.1">
        <property type="nucleotide sequence ID" value="XM_018219050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4S9"/>
    <dbReference type="STRING" id="149040.A0A132B4S9"/>
    <dbReference type="GeneID" id="28828776"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726349"/>
    <dbReference type="InParanoid" id="A0A132B4S9"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="44144" checksum="88F2B2D8BCBCD7CA" modified="2016-05-11" version="1">MTGKAPLTGLRVLELAGLAPGPFAGLLLADNGASVLRIDRAIPNVTHTDTPSRPPPPTNDLLTRHKSSVAIDLKSPSGIEFIKALVSHADVILDPFRPGVLEKLGIGPDILLGLNPKIIVGRMTGFRRDGRYKDMAGHDINYIAVSGALSMLGRKGENPLPPANILGDFAGGGATLFQGILLALFAREKTGRGQIVEANMVDGSAYLATFPRLLLNTPMWNKPRGENVLDGGCPWYDTYETKDGKHMAVGALEPQFFAELLKGLGLSGKGIERTRDDRRTWPELKHTFTKLFKAKTRSEWEVIFDGTDACCTPVLDYAELRQKDNGREGDQRPAVTLRNTPSLAVSNSDLPRDPATGQGPGIKGAGYVATILVPGRGGEETLNHWLGWKRGKDFDIENGGLIKKSSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4V4</accession>
    <name>A0A132B4V4_MOLSC</name>
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        <submittedName>
            <fullName evidence="11">SecE/sec61-gamma protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_691748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061628.1">
        <property type="nucleotide sequence ID" value="XM_018216399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4V4"/>
    <dbReference type="FunCoup" id="A0A132B4V4">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B4V4"/>
    <dbReference type="GeneID" id="28826125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691748"/>
    <dbReference type="InParanoid" id="A0A132B4V4"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="70" mass="7783" checksum="1115A0BE10CFF8BF" modified="2016-05-11" version="1">MSDQIQELMDVPRDFIHDGTQFINRCTKPDRREFIKISQAVGVGFLVMGAVGYLVKLIHIPVNNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B534</accession>
    <name>A0A132B534_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_677747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061875.1">
        <property type="nucleotide sequence ID" value="XM_018213700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B534"/>
    <dbReference type="GeneID" id="28823426"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677747"/>
    <dbReference type="InParanoid" id="A0A132B534"/>
    <dbReference type="OrthoDB" id="3543614at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="60702" checksum="F708B802F27600AF" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B604</accession>
    <name>A0A132B604_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_789496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062187.1">
        <property type="nucleotide sequence ID" value="XM_018223261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B604"/>
    <dbReference type="GeneID" id="28832987"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789496"/>
    <dbReference type="InParanoid" id="A0A132B604"/>
    <dbReference type="OrthoDB" id="5343383at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="22863" checksum="41833138C15F3E42" modified="2016-05-11" version="1">MKTPLPTTTISHDEIVAIITKFYTFLTTYPFLPATAIKTPPSEGWPEEYCDIWRKMGKSEEVVDLLARLPYIDDDNWVWYHDTMPINYTKPLNLRRIKEHYEEKRYVFEPSGVALPPHVFSLTHGKLYGKWVLLDIKARTITELGVLGGVQPAEATEEAKVGGDAWSMYPTRPIKEFFDACQDKMSGKSLVASRNYIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6H0</accession>
    <name>A0A132B6H0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062357.1">
        <property type="nucleotide sequence ID" value="XM_018216280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6H0"/>
    <dbReference type="GeneID" id="28826006"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691313"/>
    <dbReference type="InParanoid" id="A0A132B6H0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27186" checksum="5CBEB6D87DC11B31" modified="2016-05-11" version="1">MPLREWDRILASSPSMPMVLQFMDLELRLYDTDDLRSLSQFITCFPALERFTFGRQYRSWNRSGSSGDGDNLNEIVQCLFRVRTSLKYLCLESAGDCRRGCDEIQSLVEFSSLEVIDVVAFDLWLYTYDNGPDLGDDDKPLDPRVVPMVDLLPPHIRHLSLRLGSRMTVVHALGLLEAKKEQKQVSCLETLHITLTEYSHRPSKSEIDELLETGIKCGVKVIVERESLSGCLWKWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6V7</accession>
    <name>A0A132B6V7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_601668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061762.1">
        <property type="nucleotide sequence ID" value="XM_018210208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6V7"/>
    <dbReference type="GeneID" id="28819934"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601668"/>
    <dbReference type="InParanoid" id="A0A132B6V7"/>
    <dbReference type="OrthoDB" id="3562290at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="644" mass="70694" checksum="5B4C2948E8AE4C2C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B758</accession>
    <name>A0A132B758_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_556648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062597.1">
        <property type="nucleotide sequence ID" value="XM_018208379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B758"/>
    <dbReference type="STRING" id="149040.A0A132B758"/>
    <dbReference type="GeneID" id="28818105"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_556648"/>
    <dbReference type="InParanoid" id="A0A132B758"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="105" mass="12236" checksum="6E72CFFE13A589CD" modified="2016-05-11" version="1" fragment="single">AFSEEAQPKYEALSYVWGSEENPATICVCDKSDDSPFSTRKTWTSMPITRNLEVALRHLRYSVRRRVLWVDAICINQRDDEEKGRQLPRMGDIYQRARSVAIWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7L5</accession>
    <name>A0A132B7L5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative competence/damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062608.1">
        <property type="nucleotide sequence ID" value="XM_018216239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7L5"/>
    <dbReference type="GeneID" id="28825965"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691141"/>
    <dbReference type="InParanoid" id="A0A132B7L5"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="182" mass="18967" checksum="4B056AE5E509B702" modified="2016-05-11" version="1">MTSEIKYIEQTHESVFDIASDVIQMLLQAGETVGVAESLTAGSVMAALTSVPGASAAFRGGVVSYATPLKQLLLNVDAGLIAKEGVIHADVATQMAEGARKITTFDGSLTTWGIGTTGVAGPATQYGKPVGTVFIGIASPKGSQAWGPFLFSGSRERIREATVVEALSRLRKALADRQVVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7U8</accession>
    <name>A0A132B7U8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein RAD16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_711924</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018062112.1">
        <property type="nucleotide sequence ID" value="XM_018217938.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28827664"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711924"/>
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    <dbReference type="OrthoDB" id="448448at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:nucleotide-excision repair factor 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070911">
        <property type="term" value="P:global genome nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
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    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
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        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="477"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="818"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="896"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ07757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118979" checksum="6A8D473FB05A7949" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9C8</accession>
    <name>A0A132B9C8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_701533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
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            <dbReference type="ChEBI" id="CHEBI:57945"/>
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            <dbReference type="EC" id="1.2.1.12"/>
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    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217206.1"/>
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        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ09010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="36454" checksum="E7A6F765DB5A4FA9" modified="2016-05-11" version="1">MAPIKVGINGFGRIGRIVFRNAVEHDDIDIVAVNDPFIETHYAAYMLKYDSTHGQFKGEVEAVEGGLKVNGKTIKFYQKRDPTEIPWAETGAYYIVESTGVFTTTEKASAHLKGGAKKVVISAPSADAPMYVMGVNEKTYDGKADVISNASCTTNCLAPLAKVIHDEFGIVEGLMTTIHSYTATQKTVDGPSAKDWRGGRTAAQNIIPSSTGAAKAVGKVIPSLNGKLTGMSMRVPTSNVSVVDLTCRLEKGASYDEIKAVIKKHAEGDLKGILGYTEDDVVSTDLNGDNRSSIFDAKAGISLNNNFVKLVSWYDNEWGYSRRVLDLLAYIAKVDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9V6</accession>
    <name>A0A132B9V6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_763918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221615.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28831341"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_763918"/>
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    <dbReference type="OrthoDB" id="249703at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="42685" checksum="8B4503A4B8926380" modified="2016-05-11" version="1" fragment="single">DGYFDYNIAKFIGLATYSGAEIGECFETAHRIKDGDSKSWVQAWVSTARRVEAYGEEALKGNHKVSAREAFLRATTYYQAAFFFTLLSDPRKPEIYQKHTGCFQKAGKLFDPPFETLSIPFEGRSLFGYFIRGGSDSKPRPTVLIQMGADSSSEQIYFSGGGAAAVRLGYNALIFERPSQTGTYMRDNSLHYRYDWEVPVTAVVDYALTRPEVDPARIALIAYSMGGYFGPRAVAFEKRIAACVVSGLVPAIMNLVSHWTSALTAANGNYNHAQEWLLFEHMPRYGLVNGIHDLDKLLKIWESMNLYGLEDRITCPLLVVQAAAEGEENTKIAKAFYDKLTNPMNKWRLTTETDGAEIYCQKGNAMLLHAIEFDWLDDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Y4</accession>
    <name>A0A132B9Y4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_763921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063546.1">
        <property type="nucleotide sequence ID" value="XM_018221616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Y4"/>
    <dbReference type="GeneID" id="28831342"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_763921"/>
    <dbReference type="InParanoid" id="A0A132B9Y4"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77524" checksum="7E79441A9E158DA5" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAB8</accession>
    <name>A0A132BAB8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lactonohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_599492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062962.1">
        <property type="nucleotide sequence ID" value="XM_018210095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAB8"/>
    <dbReference type="STRING" id="149040.A0A132BAB8"/>
    <dbReference type="GeneID" id="28819821"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599492"/>
    <dbReference type="InParanoid" id="A0A132BAB8"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288056" evidence="1">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="433" mass="47334" checksum="8D831E746186542F" modified="2016-05-11" version="1">MKSSTAFRPAFLSVLIFTCRTTTQNLPPGVISPLVQTCGPTSKIVCINHYASVMPYHFYRQASDNASYEDTFPKTIVGNDSSFSLLPGADFLVFDQQRGLEMLGTAPSYEFMFAVNDAVHEAPVYSPATNKLYLSQLRGNTSPPGFLPQLVVNLNVDPPYLGELLSDPPIYAPNGGTIHNGLIYWGVSGGNDSIGGIEERPGIATLDPTTNKTVTLLNNHFGHYFNTVDDLFVADNGDVWFTDPQYSWFNALTDTAPQLNSASYRFRPSTGVVTMIDDTMVQPNGIAISPRMENCSATENRKVYISDSGAVTGTILQSLGSHGTGFNSTGKRTVYAFDLTSDGNHIINRRPVWFAQDFIPDGLKVARNGWIVAGTGTGVDVVDPDDGALIVRIQTNFTVQNFAWTGTDYMDFWLMGNSGIARVKWNLQGQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAG3</accession>
    <name>A0A132BAG3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_281747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063608.1">
        <property type="nucleotide sequence ID" value="XM_018206460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAG3"/>
    <dbReference type="GeneID" id="28816186"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_281747"/>
    <dbReference type="InParanoid" id="A0A132BAG3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26058" checksum="7FC4EAA3ACB4EBFF" modified="2016-05-11" version="1">MNQNLSAMAIERRQLPQVLNQAIANIPVPLTHNAAARDALLPWLALGYTPVPTPSGDGYQENMCGYYALAGSLRAAWQLWGLNGRSPTVAELQATQASQLYRDLVRANMDDLGLVEAAADEYWNALTRANMLDAQGMRLVLEAIVEERGLELDLGLGIVTEGFRVRWVEESEFDTAGFDESSVNRTSVQYDEPVNSRRGVIWVYNNGGKPDVKRVRCTPQFFLLHREGRFFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBN3</accession>
    <name>A0A132BBN3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_628125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064180.1">
        <property type="nucleotide sequence ID" value="XM_018211171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBN3"/>
    <dbReference type="STRING" id="149040.A0A132BBN3"/>
    <dbReference type="GeneID" id="28820897"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628125"/>
    <dbReference type="InParanoid" id="A0A132BBN3"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="39312" checksum="D511DB56E4214234" modified="2016-05-11" version="1">MFTTMAEFSDHQPSSSDAGIKSEEYARHWEQGGKPIANDNKARDHRKSQYTTLTNDYYNDTTDIYLEAWGESFHFCRYPRGPEAKSGAIARHEHYLAHMMGLRPGMRVLDVGCGVGGPAKEIATFVDCSVVGLNNNGYQVQKAKELAIKDGMDKMIEFVKGDFMTIPFPTDSFDAVYAIEATVHAPSLAEVYTEIHRVLKPGGIFGVFEWVLTDKFSSTNNEHMAIRLGIERGNGIPALQTKATAQAAMKKAGFELLVTEDLSEHPDRLPWWYPISGDTKSAQGLQDWMLVIRNTKYGRYAVKALVRALKLVRYAPRGTLKTTEELIAGADALVVGGKEGLFTPMYLMVGKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBZ0</accession>
    <name>A0A132BBZ0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_740352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064295.1">
        <property type="nucleotide sequence ID" value="XM_018220580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBZ0"/>
    <dbReference type="GeneID" id="28830306"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740352"/>
    <dbReference type="InParanoid" id="A0A132BBZ0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13618" checksum="946D823EE8A05CEB" modified="2016-05-11" version="1">MERNAKKVAVIGSGVAGLAAAKYLLAERDPTSDASIFDVTVFERHSEIAGIWNFTSPTEDDFQTPMYPGLETNVPRTMMTYKYCPYLEDVSLFPTHDKIKQYLEDHSTDIGDYINLNSETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDW4</accession>
    <name>A0A132BDW4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_627621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064544.1">
        <property type="nucleotide sequence ID" value="XM_018211146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDW4"/>
    <dbReference type="GeneID" id="28820872"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_627621"/>
    <dbReference type="InParanoid" id="A0A132BDW4"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="430" mass="47889" checksum="9F996629F8AE1B7D" modified="2016-05-11" version="1">MPGATFPILRVAIVGGGPGGLSSAIALSKLPNVEVTIYEKAKELQEIGAGIQIGYNCWKVLELLGVGRGVRGHVQETIIHRNGLNGKPLREQKSTAAEPRYRGQRVRRTRLQAALIAKVPEGVIKLRKRLISLTNVEGGGVHLVFEDGEEVIADLVIGGDGIRSVVRESVFPDHAIQFTGRTIWRVIIPKSLILDIPEMTSSTAWWHGTAGHFYNCLVDDPSEIPEDEQMFEIAVHNVVPAATVKEKRFSWGIPATNERVESHFTEYDPRVRDALSRVPQGLWKEFSSFSGPRLKKLIAWDKVVLIGDASHPLTGAFGSGAAFAMQDSWILAQAIPHTLSFSQPLASALDIFDSIRSPYYQRMYEHLDHQGKKIQDAKTNNPQQTFEESLDVKVKSFGGEALSWIYQNDIQEVWEEFVRNEKEHGKQSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE65</accession>
    <name>A0A132BE65_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_267150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064312.1">
        <property type="nucleotide sequence ID" value="XM_018206325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE65"/>
    <dbReference type="GeneID" id="28816051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_267150"/>
    <dbReference type="InParanoid" id="A0A132BE65"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288179" description="GEgh 16 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="24398" checksum="41341FAC5ED44A08" modified="2016-05-11" version="1">MFSKLFILALAASPLVAAHGKIAVMTGDAGGNTTGLGIQGGVIPGAGTNKQTEVDTTVFQSKNAMTDGLGKTKAGPNTLAGMSAVMAQSGTTLAQVSNGGSISGTMHIVTTDGAGPYTAVLDTTGTGAFSTGTKLAVTQQVPGKNGNIAAPKQRRFIPRMLVSMGIMKRASNVNEDYPFAATVPAGTSCTGTVGGQSGVCLVKIVNPSGAGPFGGVMALQMAGGASTSAANTTAEKRELVGAKFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSR1</accession>
    <name>A0A194WSR1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065355.1">
        <property type="nucleotide sequence ID" value="XM_018220442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSR1"/>
    <dbReference type="GeneID" id="28830168"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739219"/>
    <dbReference type="InParanoid" id="A0A194WSR1"/>
    <dbReference type="OrthoDB" id="10654741at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="49367" checksum="1DA6CA099A4067D5" modified="2016-10-05" version="1">MCFLGTKKPPRKHPKPQPPAKIICPFQSQPGNRTSKLPHHVHFPPPPPPPPSNPTPKPTFFLSKPKQKPKPKPKKQEMIPYVPVHAYGFPVPPLPPPTNHGQIAIWNYNDYTSFEQSLELSRYRERERVAKEERERKVVEERQGREWGELERFRERQWRRDDAFQGLMMESLRERIKVGEKGEKDGGGAGGEWKKEVGGLRKEVEEMKREREMGDTVAVAKARAEAFKEAREEEKAKKEKESFGWGDRDNREREYGRYSREQDGFDWDRGRGDWNQKDRGKKALEDRFDDIEIFGRGMALGRQEAQPLPTPARRPLLGERRGGFGYGGEFHYKEDSYEGYEYSHGMPWHQPHLSERRDPLRRGACPGTEGLRDGIKGVQSSLGRFEDRFRLEDAKRGIEKDFRQQYAFDRLADTVGQMNRRLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSU7</accession>
    <name>A0A194WSU7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065047.1">
        <property type="nucleotide sequence ID" value="XM_018220490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSU7"/>
    <dbReference type="GeneID" id="28830216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739689"/>
    <dbReference type="InParanoid" id="A0A194WSU7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50077" checksum="568179382B76CCE7" modified="2016-10-05" version="1">MRFTLGRKKSAPSPDKEHNTKNWFTTPYYKAVERRPWLLPPHEVAFGYTDDFPPVQSLRVLQHLYNKAAEKVEYTKCVDLDLDWDRLHETSAQLGTRAAQKKQRAVREDEAGDGLPTDILEKIGRYLSQVDLWCLRAVNRRMRYEVIGYNVEVGGRSEFGGPRDCLSFRIRSAVANRPWKMEVCPGVFSPCMRMKLWKRLENDIGTDKAEKLSCWYCVEQHPRWDFEWDSELHGYEGNLIESEDRICWEGYNLLLSRVLSWASLLYRITGKTSGMCGSSGDCTIINLKGVGRILAFDEGRPVNTMGASIFEHSVKVCSTCFMENCLRLHCPMDQRPADCYLCYKIRRVPILSATVFSGLATRTRMPDDGRLELAQKGRCWGAQKLIQSLWNGRISKSLLILDWYDQNLERKSFPAWWKMSADFQPHTKPRFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTP3</accession>
    <name>A0A194WTP3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_739528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065685.1">
        <property type="nucleotide sequence ID" value="XM_018220472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28830198"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739528"/>
    <dbReference type="InParanoid" id="A0A194WTP3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="278"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="596"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="893"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1221"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1491" mass="164780" checksum="555EF6FEF3472862" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU58</accession>
    <name>A0A194WU58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_738931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065851.1">
        <property type="nucleotide sequence ID" value="XM_018220420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU58"/>
    <dbReference type="GeneID" id="28830146"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738931"/>
    <dbReference type="InParanoid" id="A0A194WU58"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="105" mass="11970" checksum="8C033C3B92B48AF7" modified="2016-10-05" version="1">MAVGVTQYPDDIDDAFDDVTLGWEELDVLDDAGDDPKDVVHGVEELSERVLEASDDNTCELDAKDKDVEDEDRSEELLADESVREIQRYRLGSPTRTEYLRRHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUE8</accession>
    <name>A0A194WUE8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_710102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065940.1">
        <property type="nucleotide sequence ID" value="XM_018217807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUE8"/>
    <dbReference type="GeneID" id="28827533"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710102"/>
    <dbReference type="InParanoid" id="A0A194WUE8"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="59867" checksum="310503159D9EEA95" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVF3</accession>
    <name>A0A194WVF3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066004.1">
        <property type="nucleotide sequence ID" value="XM_018218757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVF3"/>
    <dbReference type="GeneID" id="28828483"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722756"/>
    <dbReference type="InParanoid" id="A0A194WVF3"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="42257" checksum="FFEF5ED54D8E2181" modified="2016-10-05" version="1">MAHLVASFNRLDRSKQLPSGLLKNHWYFTIINTESRFQITTDRTQILSLPTDAAQTDVIVPLLLGTFVKGLHRGSDILPDDVPPFAPFSWGTRSPDLARAIEVKLRALGVRLDLCTVQPGTKEQGEVADESWIKVMDLVTNTLGTALPQQASQGRCWFDEMFPVQQSILLLPECQRSDWKEHKKACGERSRTSNGQQSSSMSGQALEPSDYYHRVARTIPEAKVLADSINLPLPPRGGGLSKPIRRLVITGKDTTQNLRLLLGPNWQSASSTWSEARIEILLDAPIGSPSYAFHKRNDEGGLVSSPRSASVDETARIQTVREIQQAIRTRLGTRRQPTTQDMKAVLLTFGNNWGAMLPDYNLAVNTMDQGVPVRWGSGFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXC3</accession>
    <name>A0A194WXC3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_738038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066597.1">
        <property type="nucleotide sequence ID" value="XM_018220324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXC3"/>
    <dbReference type="FunCoup" id="A0A194WXC3">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WXC3"/>
    <dbReference type="GeneID" id="28830050"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738038"/>
    <dbReference type="InParanoid" id="A0A194WXC3"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001145">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="405"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="880"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="975" mass="109387" checksum="CAC206DC0AB2D4E7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXQ0</accession>
    <name>A0A194WXQ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1680-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_622645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067060.1">
        <property type="nucleotide sequence ID" value="XM_018210983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXQ0"/>
    <dbReference type="GeneID" id="28820709"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_622645"/>
    <dbReference type="InParanoid" id="A0A194WXQ0"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="16"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="442"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="539"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="663" mass="75783" checksum="852C2A6925731620" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXW6</accession>
    <name>A0A194WXW6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_209609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066889.1">
        <property type="nucleotide sequence ID" value="XM_018205856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXW6"/>
    <dbReference type="GeneID" id="28815582"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209609"/>
    <dbReference type="InParanoid" id="A0A194WXW6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="97" mass="10981" checksum="3DD6F79EA96A5D9E" modified="2016-10-05" version="1">MARTFFACLLAPGQGSDKSTSRPGDQHISEASSTLLLALIPLFLALEWRPWISVYLLGPFFYFPSSSHSFPSSPRSSRLQIERACMRRTLPYRTLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYE0</accession>
    <name>A0A194WYE0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067310.1">
        <property type="nucleotide sequence ID" value="XM_018213328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYE0"/>
    <dbReference type="FunCoup" id="A0A194WYE0">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="GeneID" id="28823054"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673059"/>
    <dbReference type="InParanoid" id="A0A194WYE0"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="334" mass="37393" checksum="0140F80C8A537A0A" modified="2016-10-05" version="1">MNILSTVKLSDMKASNSRLTSDTAPRIAVFVGATSGIGKATLTRLVAQQTALKVYVVGRNAEKQKSFINQLQQSNEKAQIIFIEGEISLMADTKRIYNEIKSKERSIDALFLSAGYIPWGGREKTSERIDTFSALAYYGRILFILNLLPLLKASPHSPRIVALGGAGLINPNLFLEDLDLDQLDHYTMRNTIDHVATCSTFTLSHLADENPDVVFVFANPGLVVTDIYNHGWGGRIYLRMFVGLIKPLMRMFAVPAEDAGERCLYLLTSARFGRKGAEEVSRALTMKKAEEGGLFCVTWKVESVFWETFLTEEQRQELEEKAWAKAQEVLKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYI5</accession>
    <name>A0A194WYI5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL-like Lipase/Acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_568063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067360.1">
        <property type="nucleotide sequence ID" value="XM_018208563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYI5"/>
    <dbReference type="STRING" id="149040.A0A194WYI5"/>
    <dbReference type="GeneID" id="28818289"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_568063"/>
    <dbReference type="InParanoid" id="A0A194WYI5"/>
    <dbReference type="OrthoDB" id="3915838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="21998" checksum="2488BD2D4C9215FA" modified="2016-10-05" version="1" fragment="single">STPFRIMALGASVTFGTGSTTGDSYRKDLQDLLVANGNTVEYVGSRKNGNFSNNAVEAVPGFVISQVAALANVSVPKYKPNLVLVDAGTNNCNKGGTVPDAGTNVTILINNIFRQSPNATVILTTILVNSVAEQDACRVTVNTQYTALADAMQAAGMKMVLVDMRGPGGPLVTDLADGRHPNDAGYVKMSNIWFGGIQQVISKGFLTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYP7</accession>
    <name>A0A194WYP7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_756449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067438.1">
        <property type="nucleotide sequence ID" value="XM_018221376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYP7"/>
    <dbReference type="GeneID" id="28831102"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756449"/>
    <dbReference type="InParanoid" id="A0A194WYP7"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="37637" checksum="13F47A5B8D2A3435" modified="2016-10-05" version="1">MATTSSSGRSNPYENIHVHISWWNKDQMGVPPEIVELEQVFREKYNFRTRVHRLGWSDESRAVVDLDSGLEYHDNLDVVKSVLDSSSLLIFYYSGRVRSNAAGDLMLLPRVGEQGEEIAWTYILKQLMKLYSDVLIIWDTDHTSRACIQAMYTMEFIGAADNSREMWGPTTLFSFTQFLIDVLREAAKNDDGLTAADLHSRIVSRYLDAGLVIKKEKGQESNCPPLPFYFKPRGSVVFGSIPIIKLPVEDEDEDMSHSNASPSSGSDIDSDDDDEDTSSDKGVEAIKRDLLKRPAKRAVAQRKKLLTTLKERAQRPERKRHVPIQRGGLCLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYX0</accession>
    <name>A0A194WYX0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_196326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067244.1">
        <property type="nucleotide sequence ID" value="XM_018205747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYX0"/>
    <dbReference type="STRING" id="149040.A0A194WYX0"/>
    <dbReference type="GeneID" id="28815473"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_196326"/>
    <dbReference type="InParanoid" id="A0A194WYX0"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="200"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="587" mass="66993" checksum="D905470756375C50" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ59</accession>
    <name>A0A194WZ59_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_651349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067595.1">
        <property type="nucleotide sequence ID" value="XM_018212151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ59"/>
    <dbReference type="GeneID" id="28821877"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651349"/>
    <dbReference type="InParanoid" id="A0A194WZ59"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF5">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27258" checksum="9429E5E6783D6209" modified="2016-10-05" version="1">MSTTQDPSPEMAVALFEVLEATFPDTLEEDTWYLVALSALVNVEPDHVGTLYTYLIKKSQYSTSESRQALVRRLREGLVKSIVIQGAPKCIQALFAIVKLERPEDRDYSFSRAGWQAGPENRARGEEWLKALYKHTLTTGSDRFIAHKDFEFISWEVVYGLFLSNHDILGPVETELVTLTGIMIQNMPVETTWHLRGIRRLGVKKDDVEMVHQCIELVAKFGKISLHKIPRVADIERQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZA2</accession>
    <name>A0A194WZA2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_687454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067641.1">
        <property type="nucleotide sequence ID" value="XM_018215504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZA2"/>
    <dbReference type="FunCoup" id="A0A194WZA2">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WZA2"/>
    <dbReference type="GeneID" id="28825230"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687454"/>
    <dbReference type="InParanoid" id="A0A194WZA2"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
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            <begin position="40"/>
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        </location>
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            <begin position="56"/>
            <end position="82"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="244" mass="27540" checksum="ABF1DAE215469928" modified="2016-10-05" version="1">MIPRTLLRQSRALSSSIRSSPRGSLARPQFRPSNLALPTSSQRISSSSRWYSSESTEAKKEDNAADSKSETKNGEAEDPVKKELEAKNKEIIDLKDKYVRQVADFRNLQERTKRDMEAAKAFAIQKFAKDLVDSVDNLDRALAMVPEEKLTATEKTEHLNDLIALYEGLKMTENILMATLKKHGLERFDPSVEGEKFNPNEHEATFMTPMQGKEDNTVFHTQQKGFKLNGRILRAAKVGVVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="255" mass="28853" checksum="19132C99C4FDF681" modified="2016-10-05" version="1" fragment="single">NSNSPVESEMPPNSTVILPLYIYPLPGAWDRLHTAISSNPTLHFIIILNPHNGPGACPLPDERYSEEIPKLNARANVTTVGYVRVDYYKRSLSDVFRDVEKYAGWVKREGLGIGGIFLDETPNLWEVGKGDYLDAVGEYVKSSTGLKGERLVIHNPGTVPDPEFADPGPDITTVVEEGFARYKSTLLQERLTKLLRYDRSSCVYMVHSVPERELESVVHELRHRGKYLFVTTLSSNYYCSFGTSWERFIQAMQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0U0</accession>
    <name>A0A194X0U0_MOLSC</name>
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        <lineage>
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    <reference evidence="11 12" key="1">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">CBS 120377</strain>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
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        <property type="entry name" value="APC_YAT"/>
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        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINO ACID PERMEASE"/>
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    </dbReference>
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        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="141"/>
        </location>
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            <end position="249"/>
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    </feature>
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            <end position="383"/>
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            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
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            <end position="559"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="18"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="600" mass="65586" checksum="34F9F7721521D4CF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Y6</accession>
    <name>A0A194X0Y6_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Y6"/>
    <dbReference type="GeneID" id="28829907"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736851"/>
    <dbReference type="InParanoid" id="A0A194X0Y6"/>
    <dbReference type="OrthoDB" id="10593523at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="159" mass="18192" checksum="F9D40F12FE9DEFE7" modified="2016-10-05" version="1">MPRLQNEALLALNEARIQARQFGSSLYNTIYEGTTPESPLRRYLIDYCIKSTRDIQCPKHYPAELLVDIINGTRAEKRTDGEGTNRWVMSKDDLIESYFVDEEESRQHRHNLLKEVELRQAEEESALEASTSGRAGQDESDEDASADFTWDEAFFAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1J6</accession>
    <name>A0A194X1J6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_687330</name>
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    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068421.1">
        <property type="nucleotide sequence ID" value="XM_018215473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1J6"/>
    <dbReference type="GeneID" id="28825199"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687330"/>
    <dbReference type="InParanoid" id="A0A194X1J6"/>
    <dbReference type="OrthoDB" id="10538157at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="135" mass="15446" checksum="F6670691BFB8806A" modified="2016-10-05" version="1">MKLQELFRSRESKHNKAHSDLPGYEEKIDTNPVLNTMSDFPLTGIKAGDTPKWKWTPTQCQEWLRAVFIQEFGESPDQATKMAKRIGGSGPSIYMRHRYERISLLGEGRGISLYAIILMKRNRIGAVPFSLILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1X1</accession>
    <name>A0A194X1X1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_698619</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068550.1">
        <property type="nucleotide sequence ID" value="XM_018216997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1X1"/>
    <dbReference type="GeneID" id="28826723"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698619"/>
    <dbReference type="InParanoid" id="A0A194X1X1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ14195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="26099" checksum="9AA5FF5196B6A7EE" modified="2016-10-05" version="1">MEIIKSAEAFKKVEDAYKFSYLQLIVRKNGRLYCAKSPHRKPNLSEIYDIELLETEDRDPKVKPTWTVLDSPHEYYIKTPDLWAYSSPHLEQQILREVEACELLKPHPHPNVAVYYGCRSTNGRVLGIFNPRYLSKSDFLTSRLSVDDTTKACLDGIIAGIRHLHSLGIIHNDITPSNIMFKEDGTPVLNDFGSCRMTALENNDFDAFTELQTWLIGSSADKFLFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X378</accession>
    <name>A0A194X378_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_588754</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069010.1">
        <property type="nucleotide sequence ID" value="XM_018209499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X378"/>
    <dbReference type="FunCoup" id="A0A194X378">
        <property type="interactions" value="1018"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X378"/>
    <dbReference type="GeneID" id="28819225"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_588754"/>
    <dbReference type="InParanoid" id="A0A194X378"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="162"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ14655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="431" mass="47326" checksum="A81E17AB04109428" modified="2016-10-05" version="1">MSNTDFLGRAIESVKKAIEADTAAEYEKAYQLYYSSLELFMLALKWEKNAKSKEMIRAKAGEYMERAEKLKAHLADDAKRKKPGMVGANGTSTGGGGKGKEEEGTDPESQKLRNALAGAILQDKPNIRWEDVAGLEGAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFAMARENKPSIIFIDEVDALCGPRGEGESEASRRIKTEMLVQMDGVGRDSKGVLVLGATNIPWQLDAAIRRRFQRRVHISLPDLPARTKMFEISVGSTPCELTGADFRKLGELSEGYSGSDISIAVQDALMQPVRKIQTATHYKKADNGEEKLTPCSPGDAGAMEMTWTEVDSDKLLEPPLQLKDFIKAVKGARPTVSQEDIKRSEDWTNEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4R9</accession>
    <name>A0A194X4R9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_649370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069167.1">
        <property type="nucleotide sequence ID" value="XM_018212056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4R9"/>
    <dbReference type="FunCoup" id="A0A194X4R9">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="GeneID" id="28821782"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649370"/>
    <dbReference type="InParanoid" id="A0A194X4R9"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="642"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="570"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="752" mass="85764" checksum="0C464E00A65CA3D5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4U9</accession>
    <name>A0A194X4U9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_708143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069558.1">
        <property type="nucleotide sequence ID" value="XM_018217662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4U9"/>
    <dbReference type="FunCoup" id="A0A194X4U9">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X4U9"/>
    <dbReference type="GeneID" id="28827388"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708143"/>
    <dbReference type="InParanoid" id="A0A194X4U9"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
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        </location>
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            <position position="53"/>
        </location>
        <ligand>
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            <position position="62"/>
        </location>
        <ligand>
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        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        </source>
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    <sequence length="994" mass="111082" checksum="7B0BAD3F921DF976" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="KUJ15258.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="1653" mass="186694" checksum="C42B46F32D9BFF28" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28832370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783053"/>
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    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="58133" checksum="F6293CEE378F3DED" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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    <name>A0A194X7E9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070087.1">
        <property type="nucleotide sequence ID" value="XM_018215129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7E9"/>
    <dbReference type="FunCoup" id="A0A194X7E9">
        <property type="interactions" value="1092"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7E9"/>
    <dbReference type="GeneID" id="28824855"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685677"/>
    <dbReference type="InParanoid" id="A0A194X7E9"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="219" mass="23915" checksum="EC170239DF086A9A" modified="2016-10-05" version="1">MSIGVRGKDCAVVLSQKKVPDKLIDPSSVSHIFQLSPSVGCVMTGSIADARASVQRAIGEAAEFRYKYGYEMPCDALAKRIANISQVYTQRAYMRPYGVATTLISLDSEYGPQLYKCDPAGYYTGYKGTASGPKQQEAFNHLEKKLKNKDCAEGSWEDVVELAITTLSTVLSVDFKKGELEIGIVGGPRKDGKEGTDPGFRALTEEEIDERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Q0</accession>
    <name>A0A194X7Q0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070484.1">
        <property type="nucleotide sequence ID" value="XM_018215031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Q0"/>
    <dbReference type="GeneID" id="28824757"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685170"/>
    <dbReference type="InParanoid" id="A0A194X7Q0"/>
    <dbReference type="OrthoDB" id="273230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16932" checksum="E8D2B915AA56661F" modified="2016-10-05" version="1">MNTLRLSATRGARCIRRSTFSSLRASSYLPKQTTLRPQLQSSLRTGTFSKHVARRQYSTKSSADSLIEDIQEQYATARDEFEIAAEETEKKSVYAADDRAAAREELDKLKSMYEEALRGADGEEIKSRVGQRIRELDSAVQAMEKSAMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Y5</accession>
    <name>A0A194X7Y5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_734392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070636.1">
        <property type="nucleotide sequence ID" value="XM_018219904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Y5"/>
    <dbReference type="GeneID" id="28829630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734392"/>
    <dbReference type="InParanoid" id="A0A194X7Y5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="36623" checksum="FAE9C2E0C14A659A" modified="2016-10-05" version="1">MTRPDSTNTTQKASNGGHTRGVARPNTSGERRAASNTARRQDHTVQNTGRTEPAKPHPASGRRSTGSTTDEEDYRELFIRLQNTGRQRNSNSSSTRRSRSDNTADPPKPVRQTTSEDTVDTLPIELEQGEDNSNGDGLDEKTHLDALIDATDKFLGPSDPDYPIVLTGAGPKFLDEIQSSKSTKKRKTPRKTSKEIRQGTPFPDEARTTTKKRIGTENGEPQDESYGTSQYLEPSHKRRRIISDSEHSPVPNSIDSNLDISDKETRNFGPTPKNPLYEVQSPKSPPEPPSWERWGTGKRFKFKPRATQQEIKGSQPDGAKDSVKDGAEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X849</accession>
    <name>A0A194X849_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_617425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070644.1">
        <property type="nucleotide sequence ID" value="XM_018210803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X849"/>
    <dbReference type="GeneID" id="28820529"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_617425"/>
    <dbReference type="InParanoid" id="A0A194X849"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="38044" checksum="B122AC236DF14427" modified="2016-10-05" version="1">MNRKGQPGQTKKRNRVTVACTECHRRKQKCDRAEPCSDCQERGVPQKCQYQKPKVEQESAPKVAGKTVVSRFRRIMSGEEVIMTSESVAALADPMSVSALVPTSEPVIIPYATDLRSQECLDSLRTRPSGYAFTTRPVPATVASGLNYNNSLNNYDPFSILPDIKGEPLPKQILIRYYVERLAPWLCNLDDRFRGVDDLEIIPVPKIAWLGYAVEHTAFYYATLLTAAVHLNRRRKLKDPGALIWYKVHTIQLANEKMNVAEEAASDEMIMTALVLCYFNVGGNNVDEYEIHLRGIDQMLKVQGGKEATGMRGMVKNWLGVSHGPWSPGFEYGAFVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X932</accession>
    <name>A0A194X932_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_586483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070974.1">
        <property type="nucleotide sequence ID" value="XM_018209369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X932"/>
    <dbReference type="STRING" id="149040.A0A194X932"/>
    <dbReference type="GeneID" id="28819095"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586483"/>
    <dbReference type="InParanoid" id="A0A194X932"/>
    <dbReference type="OrthoDB" id="2596908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="31128" checksum="55BD0BC08DFDA01D" modified="2016-10-05" version="1">MEESMRRYVDSIIEPLERRQASPTVPSTGINVTEWDAQTQAACTTSLEALNGVSNNPSGMAVCYNLPYLDNSTGVFEADLRLYMIAAPTGDFVNIASSNVQVGLSYNGATVSTVNASSLKRRSDATSLISWPRAVEVVKRATVPTLVQSYAFVGQINQNLLTTNMGTAALQKVLVPTVTLTGTDSTGAQVNTSLSSDEATFVSGVFAEQATTTVTKAAVDPPIQTLVVASDAPFVVPGLNILIIPIGLIITSIWTVLFVATIAYGTVGRMQFREQYRRRSARAEKGDVPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X943</accession>
    <name>A0A194X943_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_645557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071043.1">
        <property type="nucleotide sequence ID" value="XM_018211886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X943"/>
    <dbReference type="GeneID" id="28821612"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645557"/>
    <dbReference type="InParanoid" id="A0A194X943"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30252" checksum="FC01D5C54DD17FE3" modified="2016-10-05" version="1">MYQATPKQSAPEPGPQAIHHEWRTAENSATYVQSKLRSMKELKPNLTLLDVGAGSGTISITFAKAIPKGLVTAIDLNPDILTRAATVADSEGVTNIKFQQADAYKLPFADETFDITHCHQVLCHLKAPWGVLREMLRVTKPGGILAAREGDLETECVWPELPGLLRFHRLAVDIIKIGGGSTNAGRQLLSWALKAGAKREQATATFGTWCYSERADKDAWAQGIIKMVGAGRVHDLALKMGLATEDELVGMGKAWQEWQETDDATLGMLHGEILIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X955</accession>
    <name>A0A194X955_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_697098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071053.1">
        <property type="nucleotide sequence ID" value="XM_018216876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X955"/>
    <dbReference type="FunCoup" id="A0A194X955">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X955"/>
    <dbReference type="GeneID" id="28826602"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697098"/>
    <dbReference type="InParanoid" id="A0A194X955"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03816">
        <property type="entry name" value="GT33_ALG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000162">
        <property type="entry name" value="Beta-1,4-mannosyltransferase (Alg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="441" mass="48668" checksum="247146B6418C6049" modified="2016-10-05" version="1">MLPSRYVKHSPPKATSIASATEPKISAQVLVLGDIGRSPRMQYHAASIAKHGGRVDVIGYQESSLHPALVGNPLVTIIPLPPPPSLLRSNALPFILGGPLKVLWQIWSLFYTLAYVTKPSRWLLIQNPPSIPTLFIAMVICFLRNTHLIIDWHNYGWTILAGTRGDNHPFVRISKYYEAILGSWAPTASFTVTHAMQKQLRNEPYNIRSPIFTLHDRPAAIFQPVSGTEARRAFLERLPETAEHAEKILAGKTRLLVSSTSWTPDEDFSLLLEALCSYASSSKPLPPILAIITGKGPQKQMYLDRIASLTRDSKLQNVKILTAWLSAEDYATLLACADLGVCLHMSSSGVDLPMKVVDMFGAGLPVVGYGNYESWSELVKEGVNGRSFVTSAELAQVLGELFSDPEAKELSMLRKGAVSEGKRRWDEEWDEVAGRLLGLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9W9</accession>
    <name>A0A194X9W9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071318.1">
        <property type="nucleotide sequence ID" value="XM_018214990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9W9"/>
    <dbReference type="GeneID" id="28824716"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684953"/>
    <dbReference type="InParanoid" id="A0A194X9W9"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22820" checksum="8B643292421EB6E9" modified="2016-10-05" version="1">MATLPTAAFKLHGGCFCNAITYTISVPDLTSRPLNPSKPSKPLGPRNEVNARLPCIALDHCTTCRRIPGSILQVWFICPQSWAEFSLQPRSHDTATTPIKISTSEFLLPDKDVQERTWVTGFQSSEFAHRTFCGRCGTHLSFFYTGLDQKLAEEANWGPYFDLVLGSLNKESLEVEGLWPDRQVWVGSGIEWVKQLVAEGEGSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAL8</accession>
    <name>A0A194XAL8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_669594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071539.1">
        <property type="nucleotide sequence ID" value="XM_018213107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAL8"/>
    <dbReference type="GeneID" id="28822833"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669594"/>
    <dbReference type="InParanoid" id="A0A194XAL8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="20281" checksum="9D8F25D0B05E9AEF" modified="2016-10-05" version="1">MPLPDLAKVVISRNRFPSVRRGSGFGFTQWIELAWQLDHEGLRFHRPPRAIGPIDLKCDIDIWVQDLVGSWAAHPARGDYVSGCIVRRTGPLRLVQVAVCCLIYHANALPGATFNVPRDAQSEVVFAQFRVTRTALLGSRAWLRDPPSPCPREVMKSRGRIQSGWWRFRHDFKAFNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBG2</accession>
    <name>A0A194XBG2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_54620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071853.1">
        <property type="nucleotide sequence ID" value="XM_018208246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBG2"/>
    <dbReference type="GeneID" id="28817972"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_54620"/>
    <dbReference type="InParanoid" id="A0A194XBG2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268100" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="16993" checksum="952585FA2458CEB7" modified="2016-10-05" version="1">MAVSRWTGGCVFSTLLCSKLVFLASSIFGSSALDSSGFVASLTIGSEAGATVSVTASMCPSAAIVTFNETGFSSPFEFGISSVASSVLLSSAFASGVMSFVGTDVSSLLSCFVTRVSTLLLSSTLGRAGTSLFSPSAWGKSSAFTSSTTVCATPFTCPSAPTVIFKVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBP8</accession>
    <name>A0A194XBP8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_57884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071946.1">
        <property type="nucleotide sequence ID" value="XM_018208969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBP8"/>
    <dbReference type="GeneID" id="28818695"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_57884"/>
    <dbReference type="InParanoid" id="A0A194XBP8"/>
    <dbReference type="OrthoDB" id="4764735at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="317" mass="36505" checksum="0AD171700849F90B" modified="2016-10-05" version="1">MTRPRTPTKPHLNTKPRPQAPQSKEKPTPSRPNISPEEAARRSHLTPAERSAEALDASRAAESQHEGELWKCSPSSEEPSSSSRRSASDQEKDAAHMRSFFSNSRPAFFDAQGDPIPFTGSASSYFFGTGESQSGPQYTRKATRQEEKKERQRRAQAEQDAKREQEYLESEYLESSPPVDDEYWAALLLSQQRDKKEWGMYYLVLVADLRAFKSSRQDGVEFPALPNLRCPREDRLKGELIGCCHHDLEKVFRGSGMYSREWLRRERHQWHPDKFSRLGQNAVERSTEVFKLCQKLLETKRCKFPLLSLPNTQMNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCC0</accession>
    <name>A0A194XCC0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_584494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072170.1">
        <property type="nucleotide sequence ID" value="XM_018209265.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XCC0">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="GeneID" id="28818991"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584494"/>
    <dbReference type="InParanoid" id="A0A194XCC0"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD42</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kennedy M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 120377</strain>
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        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18231.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1253" mass="138055" checksum="1BA90D0299BF55E1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDM1</accession>
    <name>A0A194XDM1_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_44486</name>
    </gene>
    <organism evidence="4 5">
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072628.1">
        <property type="nucleotide sequence ID" value="XM_018207575.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XDM1"/>
    <dbReference type="GeneID" id="28817301"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_44486"/>
    <dbReference type="InParanoid" id="A0A194XDM1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="632" mass="70350" checksum="C368838DF9C8C5F8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFQ9</accession>
    <name>A0A194XFQ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysozyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_643599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ19003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073358.1">
        <property type="nucleotide sequence ID" value="XM_018211803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFQ9"/>
    <dbReference type="GeneID" id="28821529"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643599"/>
    <dbReference type="InParanoid" id="A0A194XFQ9"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268244" evidence="7">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="282" mass="28971" checksum="0E8515821BCDAE09" modified="2016-10-05" version="1">MKLSYVCFLALGSFAEAICRGSCKLSVDASDLAADTCTINSGQKGECILTSTCSSQGGTSQVGHCPGAADIQCCTYGSCTVNGEEGTCQPTGTCSGTKTAGHCPGPSDIQCCTSSKGGCTAPSVNAATISLIKSFEGFVASPGSDPIGLPTVGYGHLCETKGCAEVPYPFPLTTTTASELLASDLKKFEQCVSEDIDSSIHLNANQYGALVSWAYNVGCDNVASSTLIKRLNAKDTPDTVASEELPKWDMAGGQVEPGLQRRRAAEVKLFETASGVAALPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFX4</accession>
    <name>A0A194XFX4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_667711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ19029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073384.1">
        <property type="nucleotide sequence ID" value="XM_018212995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFX4"/>
    <dbReference type="GeneID" id="28822721"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667711"/>
    <dbReference type="InParanoid" id="A0A194XFX4"/>
    <dbReference type="OrthoDB" id="3588018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="27123" checksum="9AE5FD4B603B946E" modified="2016-10-05" version="1">MIFKGLKESFRTRRSRSRPPSALPTFNMERASEGDRFEREERIDRLQETMNVFSRLGHSISSKNIKLPPIPSFKPLNLSNLDIFKSKDDPVSDVPAEIRRKPCPVNPEAFDTATLSPSMTPAEILHHKFRAFDPCAPVTNPLLHMRAREALKRRYESKFTIDFDPPAGITAREYNFMWCDEGELDLKVLQDIVWVRERYAQARKGEPTDEDVIRWYDAERFDVGTESVTEGSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGB0</accession>
    <name>A0A194XGB0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_696265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073167.1">
        <property type="nucleotide sequence ID" value="XM_018216817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGB0"/>
    <dbReference type="STRING" id="149040.A0A194XGB0"/>
    <dbReference type="GeneID" id="28826543"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696265"/>
    <dbReference type="InParanoid" id="A0A194XGB0"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="48826" checksum="7A25ACCB124A8520" modified="2016-10-05" version="1">MSIAVPSILERGFASQDIITRDVVIIGGGATGTYAAVRLREDFNKSVVVIEKTGRLGGHTETYFDPVTGYPVDYGVQAWVDGPIVRNFTGRFNISLVPAVSPPFATDYIDFKTGKHVIPPFTNATIIGQALGTYFQLILQWPFLAEGYNLPSPIPADLLLTFGDFVNKYGIQAAVPTIWTFSQSVGDILNTPTIYIVQTFGISEVQAVLENGFVVPADHFNSELYLKASALLGADVLYGTTTIDVARHDVGLQQITVQTPTGQKLIKAKKILVTIPPTADNMKPFTLNHHESSLFNQWQYTTYYTGIIRNGVPDDVNVINTQSGTEFDLPTLPFVQEFSFSGVPGLHTFHTVSTKSQTDADVESLILSDLTAMSSAGTFPASSPSIEVLSNHTPLGLRVTADSIAAGFYANLYALQGLKGTFYTGLAWAGDYTSVLWTFTDALLPGIAAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGV5</accession>
    <name>A0A194XGV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_642478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073785.1">
        <property type="nucleotide sequence ID" value="XM_018211753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGV5"/>
    <dbReference type="GeneID" id="28821479"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642478"/>
    <dbReference type="InParanoid" id="A0A194XGV5"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="317" mass="35016" checksum="2C8CB4433FA4197E" modified="2016-10-05" version="1">MRRKALLIGINYYGTKHQLNGCINDALNVQRYLVEDRGFNPAPHDMVVMTDDPKNRGTPFEPTGKNMMEAFKWLVTGNNPGDSVWLSYSGHGAQVKDPDGDRESGFDDTICPLDFQTNGQIDSDTLHRVLVSPMIPQARLTVLFDCCHSGSAIELPYVYRPNSQGEVNLVDNVKKGINLASQAYQLMQGGFNARKIQDAKMLIGGAKSLLASFQHREQEHNEDGLGEEKFMEDWKHEGKDVWMFSGCADNQTSADTSIAGAATGAMSHAFISTMRQSPNQSYVQVLQSTRAGLAGKYQQIPQLSCGGEYNLNQPVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHB9</accession>
    <name>A0A194XHB9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_496240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073960.1">
        <property type="nucleotide sequence ID" value="XM_018207929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHB9"/>
    <dbReference type="GeneID" id="28817655"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_496240"/>
    <dbReference type="InParanoid" id="A0A194XHB9"/>
    <dbReference type="OrthoDB" id="5430916at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="674" mass="74524" checksum="706975EF9F59348E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHW0</accession>
    <name>A0A194XHW0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-alkane-inducible cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_772252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074076.1">
        <property type="nucleotide sequence ID" value="XM_018221906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHW0"/>
    <dbReference type="STRING" id="149040.A0A194XHW0"/>
    <dbReference type="GeneID" id="28831632"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_772252"/>
    <dbReference type="InParanoid" id="A0A194XHW0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="58655" checksum="D7CAB032276DE82A" modified="2016-10-05" version="1">MLTQIQLAFFIAALFVVYTSFLQARLYLKRRQFAKSHGCLEPRCKVPLKDPVLALDFVWKTLQNAKSDRYLEGTYERFQQYGSTFTAKHLHYPTIHTTEPENIKHILATAFDDFKFSSFRVNAMIPLFGKGIFTSDGARWSHSRAVLRPSFARHNMTDHLPFMESHVDQLIKAIPKDGSVVDLQKLFFAFTMDTATEFLFGHSVHTLYNMQLGNDAVADDSDANFVDSYTYACLDIVHNIRLGALSKLRYSPKAKQAQKRAFAYIDRFVDEALALRNSSKSSRADETSKYIFLNELAKETGDRIELRDQILNVLLAGRDTTASLLSNTFWELARHPDIYAKLRDEVAFLNGREPTYEELKDMKYLKFCLNESLRLRPVVPANTREAIRDTILPRGGGEDGCSPMFVKKGTHVYYSVWSMHRREEFFGKKTEEYIPERWEGLKLGWEFLPFNGGPRICLGQQFALTEASYLTVRLLQKFSRIEARDSRPWTELYTLVAYSKHGTLVSLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI30</accession>
    <name>A0A194XI30_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_641233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074235.1">
        <property type="nucleotide sequence ID" value="XM_018211704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI30"/>
    <dbReference type="FunCoup" id="A0A194XI30">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XI30"/>
    <dbReference type="GeneID" id="28821430"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_641233"/>
    <dbReference type="InParanoid" id="A0A194XI30"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000009">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="26349" checksum="F28D17D90A4869DC" modified="2016-10-05" version="1">MVITTPFQTLFAVPMTCESCVKDISGSLYKLSGIQKVEANLKDQLVTIEGTAPPSAIVATIQATGRDAILRGTGTSNSAAVCILETHSTSVSDKVRGLARMVQVSSDLTLIDLTLKGLSPGTYWASIRETGDISNGAISTRGIWSDPKENSIKPRGVLGTVQVGKDGIGSVFLDKPVQIWEMIGRGMVVSKQVQEGKGKFERNDEDTLVGVIARSAGVWDNDKTVCSCSGKTLWEERKDEVQKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIK2</accession>
    <name>A0A194XIK2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_779825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074304.1">
        <property type="nucleotide sequence ID" value="XM_018222331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIK2"/>
    <dbReference type="STRING" id="149040.A0A194XIK2"/>
    <dbReference type="GeneID" id="28832057"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779825"/>
    <dbReference type="InParanoid" id="A0A194XIK2"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="144"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="258"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="49022" checksum="ADAD37B425E4622C" modified="2016-10-05" version="1">MSADIPILAANRVSDRAKKTLDIVKQFVEERCIPADPVFAAQVDAGGDRWDHHPSVIDDLKEEAKKLGLWNMFLAKGHYKEGAGFTNLEYGLMAEYLGKSRCASEAVNCAAPDTGNMEVLAKYGNEAQKKEWLQPLLDGKIRSAFLMTEPDVASSDATNIQLSMKREGNEYVLNGQKWWSSGAGDPRCKIYIVMGKSDPGNKDVYKQQSVILVPANTPGIKINRMLSVYGYDDAPHGHGHLSFNNVRVPASNMVLGPGRGFEIIQGRLGPGRIHHAMRTIGAAEKALEWMLLRINDPKKTPFGKQLKEHGVIIEWVAKSRLEIDAARLVVLNAAIAIDDRGAKGALKEIAEAKVLVPSMALTVIDRAVQSFGGAGVCQDTPLANMWAQIRTLRLADGPDEVHLQQMGKNENKKGKAVSAKILRQAEITKDLFAKYGVSLSHIGPKSKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-09-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK05</accession>
    <name>SCPZ_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cyclic ether formation enzyme scpZ</fullName>
            <ecNumber evidence="5">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Scp cluster protein Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scpZ</name>
        <name type="ORF">LY89DRAFT_682183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Genome Announc." volume="4" first="0" last="0">
            <title>Full Genome of Phialocephala scopiformis DAOMC 229536, a Fungal Endophyte of Spruce Producing the Potent Anti-Insectan Compound Rugulosin.</title>
            <authorList>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R.B."/>
                <person name="Kennedy M.C."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
            <dbReference type="PubMed" id="26950333"/>
            <dbReference type="DOI" id="10.1128/genomea.01768-15"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DAOMC 229536 / CBS 120377 / 5WS22E1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Genome Announc." volume="4" first="0" last="0">
            <title>Full Genome of Phialocephala scopiformis DAOMC 229536, a Fungal Endophyte of Spruce Producing the Potent Anti-Insectan Compound Rugulosin.</title>
            <authorList>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R.B."/>
                <person name="Kennedy M.C."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
            <dbReference type="PubMed" id="26950333"/>
            <dbReference type="DOI" id="10.1128/genomea.01768-15"/>
        </citation>
        <scope>ERRATUM OF PUBMED:26950333</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2021" name="J. Am. Chem. Soc." volume="143" first="5605" last="5609">
            <title>Biosynthesis of para-cyclophane-containing hirsutellone family of fungal natural products.</title>
            <authorList>
                <person name="Ohashi M."/>
                <person name="Kakule T.B."/>
                <person name="Tang M.C."/>
                <person name="Jamieson C.S."/>
                <person name="Liu M."/>
                <person name="Zhao Y.L."/>
                <person name="Houk K.N."/>
                <person name="Tang Y."/>
            </authorList>
            <dbReference type="PubMed" id="33834778"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable cyclic ether formation enzyme; part of the gene scp cluster that mediates the biosynthesis of a hirsutellone-like compound that has still to be identified.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic ether formation enzyme xenC family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074794.1">
        <property type="nucleotide sequence ID" value="XM_018214453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK05"/>
    <dbReference type="GeneID" id="28824179"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682183"/>
    <dbReference type="OrthoDB" id="5413841at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268322" description="Probable cyclic ether formation enzyme scpZ">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="33834778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="33834778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="33834778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="124" mass="13564" checksum="AD5D8F18FBB71463" modified="2016-10-05" version="1" precursor="true">MSSLHIFSDVLALSIAAFSALCVQAHLTKRFTPTFSKNLEEKLPQHNKAVFWWLGISDNALRYVFVSLNILVSVSLALADLRTTGLKVSMGLLFIGFYSDMKLGESPIPHLILCSVVGAAIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL23</accession>
    <name>A0A194XL23_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate dependent xanthine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_455914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075186.1">
        <property type="nucleotide sequence ID" value="XM_018207635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL23"/>
    <dbReference type="GeneID" id="28817361"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_455914"/>
    <dbReference type="InParanoid" id="A0A194XL23"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="408" mass="45909" checksum="5176424EB3BFA4FA" modified="2016-10-05" version="1">MPSAILPSSPLFTIQQLSPELRKDTLIGAEVLLNNSDGSIDPSTFTPDNISILRQALYENSVLVFRKQQGIDPLALEQLAAIWDEDMINVHSAGKDQVRDPRSILSRNNGARLPAAPNVQVIGNGEFHNYEGLEYMNLRHVDSAEFHAEPLTEDELADGQTRFYRWHQDAPLYENLPGKVTLIHAVVVPKLPNQKIKFQDGQEMKLQAGSTAFISGAKAFQLLTPEEQEFALNTTVQYAPRAYEWIRNAKATSDGLGIVKVGAEAKEEDLPPWTWDKVQAFPVRLHLCLRYLLIASQMAWKNPGKPSQPHLQILGCCVHSLRTTDTKTGAVTGIDDLAETRRICYEMQRKVVKPQHVYAHHWEEGDLVIFHNYGVWHSITGQLGTTQRLMWQVTMRSGKEPEPARINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLJ3</accession>
    <name>A0A194XLJ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative WHI2-like protein P4H10.16c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_578935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074997.1">
        <property type="nucleotide sequence ID" value="XM_018208975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLJ3"/>
    <dbReference type="FunCoup" id="A0A194XLJ3">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLJ3"/>
    <dbReference type="GeneID" id="28818701"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578935"/>
    <dbReference type="InParanoid" id="A0A194XLJ3"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="408" mass="44415" checksum="18CE2B0B63F6556B" modified="2016-10-05" version="1" fragment="single">SRAQSPPPQYPISEASGSSPPSPRPPPFSSLYTSTAEAVEAYKTAVTEAGASASVPAYAPVASEPSNSRDRDVSAETKAALPQDTKGESSKKDEDSEPPPAYSEGSSPLESFTYLMAAAGGAASIITQVQQGGAPPINTLGDVGADENITMDLRGQRFTLSRDELLTLPEFVLLSLFPNGLLPDGHLNTYHEGDAFQVDYDPASLQYMLEFFRNVAQTIPTSESPSAEPDAVPIEPMAGSAREMLQDRAGIIVLREDLDFYVIPPKAEIEQPEMIEVKRAAGKALLRQDGIFSGLRRSEETGTTEQHLIEMLTAGGFNHDDTWGHRANEPNKAVICSLALARLRTDIRSDMGNNAVGMAQKLLLFWRKPARRCWWEGVELDNVDGVEGKLKVWIRRVWTLEMSVIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLK2</accession>
    <name>A0A194XLK2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_424490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075413.1">
        <property type="nucleotide sequence ID" value="XM_018207430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLK2"/>
    <dbReference type="GeneID" id="28817156"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_424490"/>
    <dbReference type="InParanoid" id="A0A194XLK2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268425" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21893" checksum="C461665119FA3199" modified="2016-10-05" version="1">MVGSEKQHMTCNAALLLPHWGLWCFLGDSSAVVHCTSKDLLQFLQCCCQSPNSHGEVLGRWDIAHLYRPVKTHLIRWRSSDSTPDFESAASHVIQKTIIYPSVCTDKHRFARVTKRSNCASHLYPPYIVHIETRSSFSATRCFAYNKWSGVLHLLGQFVAPSQIKRSTFHPTSSFHGFMIQDIRTFSKRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMB4</accession>
    <name>A0A194XMB4_MOLSC</name>
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        </recommendedName>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        <property type="entry name" value="Caspase-like_dom_sf"/>
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        <property type="entry name" value="Pept_C14_caspase"/>
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    <dbReference type="Pfam" id="PF00656">
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    </dbReference>
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        <property type="entry name" value="Caspase-like"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
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    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="282" mass="31598" checksum="B0228C46813C7163" modified="2016-10-05" version="1">MENEQFVTLSAGGMQPPSSPNPEPISFDSSSEPDSSEDCSSLPATESPNSDDSSLFDDQSAASGIFPNKGQSRYHSVRVLLLRWEEDSLGVQYELDDLAKTLDGYGFDTETWLIPTIKSHRALMHKALQVVDDYGESDTLFIVYYAGHGRMNTSRQAEWTCSVDNKPISLQWHAIQTLFEQADSDVLLLLDCCAAASGVLTGSDNTNVTETIAACGFETWAPQPGRHSFTNTLIAVLEEWQERPAFTAAMLHCEILNRLRHEKPERYRATKKFEYRNHQSMY</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_018219411.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
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    </dbReference>
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        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
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        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
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    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDH-cyt"/>
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        <property type="entry name" value="CBD9-like"/>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268459" description="Cytochrome b561 domain-containing protein" evidence="9">
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        <source>
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            <dbReference type="SMART" id="SM00665"/>
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        <source>
            <dbReference type="EMBL" id="KUJ21017.1"/>
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            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="581" mass="64407" checksum="FB30FCB2BD44415A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMP2</accession>
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        <recommendedName>
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        </recommendedName>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="92658" checksum="F6B41398E7FF3F25" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMZ4</accession>
    <name>A0A194XMZ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB/POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_694184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075990.1">
        <property type="nucleotide sequence ID" value="XM_018216685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMZ4"/>
    <dbReference type="FunCoup" id="A0A194XMZ4">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XMZ4"/>
    <dbReference type="GeneID" id="28826411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694184"/>
    <dbReference type="InParanoid" id="A0A194XMZ4"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54855" checksum="6E73727123682605" modified="2016-10-05" version="1">MNTDIPNILPHERVFPIQIGSELFRLSGASISSDAPSYFSQFFQCQLKQAEENGDDSNSIRTLYIDRDPVTFKDISLHLQGYHVAPRDGSHFVKLFADAQFYSLPRLIFQLYEESIFISIGHRDFQIPRELFSDPGNSPNYFSLGFAVFFSTPTEVFPGLSREGLLRPPSIMPPSVPNRSADTFAELLHLLRGYPLHIKSEDHRAELLRDCRYFHLKGLEQKLIRHSITFNLARKRSEIALRLEDVRQSGISVVTFPSDSDSTSPPPDPGPATPVYNASHFSLAYVNYARPFVDEQSYELVLEIGDECTRLHLSSMRCEFFGDGKARISKLFDVIATKLNLPNILPLGLLMKKGGASSQPPSPGNTPISEDWVRCVVGEEAYVRLDGKEWRGHGNLPERGDGDSGGSNASSVIGVDESFGEPSRKRRRGLDGGVAVGGGDERQSWVIKTGQWRLRIQNSRNGHRGVECLLVAVKLDAVSGEFGRNAQRGFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNF8</accession>
    <name>A0A194XNF8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_608105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076041.1">
        <property type="nucleotide sequence ID" value="XM_018210484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNF8"/>
    <dbReference type="STRING" id="149040.A0A194XNF8"/>
    <dbReference type="GeneID" id="28820210"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_608105"/>
    <dbReference type="InParanoid" id="A0A194XNF8"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="709" mass="79756" checksum="7B17233A8AE1FAEC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP59</accession>
    <name>A0A194XP59_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_767517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075877.1">
        <property type="nucleotide sequence ID" value="XM_018221758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP59"/>
    <dbReference type="GeneID" id="28831484"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_767517"/>
    <dbReference type="InParanoid" id="A0A194XP59"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="476" mass="52878" checksum="7671FF3989435D2A" modified="2016-10-05" version="1">MSHPKQSIHVGLCGAGIGGLAAAIALCRAGATVTVLEAAAELGEIGAGIQMTPNASRLLMKWGVADLIGDNLVEFEELNMRKRDGTKVGYTRMMPNIKKDLGYPWWVVHRAHLHAGLVEVAERHGAKILINSRVTSISYKSSQLVTVTTSTDSTYTFDLLIGSDGVNSVVRRTLFPDIRPTPPTSNCAYRAIVPYAQIREDLIARELIEKLTMEVWMSDRSYIITYPISAGQDFNLVLSHHVPNDRLVESVEDVDIKEVRDEYADYDPRIKRIVDMIPSAQRWPLLVTGPLKSWTSNEKNIVLMGDAAHSMTNHMAQGAATSMEDGAFLGRCIRSVIAGQITLSQALEIYEKERMPKTHFKQQVSFLNGAIWQLPDGSAQGARDAAMQAELEGRPFSRSSNLYGDPQTVLRVYGYDAEAHADGAVHEYLKGRKRGDWRKGMGIEKEVLDGIVRWWLPEEEGREEANEYGVQIESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPI0</accession>
    <name>A0A194XPI0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_694405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076334.1">
        <property type="nucleotide sequence ID" value="XM_018216703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPI0"/>
    <dbReference type="GeneID" id="28826429"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694405"/>
    <dbReference type="InParanoid" id="A0A194XPI0"/>
    <dbReference type="OrthoDB" id="5409998at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="345" mass="36952" checksum="759EAEA316C5ABB4" modified="2016-10-05" version="1">MSQPRPKNPLDVLQSMINAILIETGKALRSAQKENGRPSTAATTRLRAMVPSTTDNFHQALDDIECEILRAKAVIFRDYEELRSKRLALENPEPIIEEPEPQAMEADMNGTSSTPADTTQDTSTPIKAEPRLVESPEKEAVLSEDTLKQETSEATNDMKGQNLTPPSSGNANGADSKPIGLGIDTDGAVDGPGPATAELQNSSIDSLFGPDDNNAGDSALDFGIMDFLTNTNTEGNDQSQNNQNNDFDLANFGSSTQDFNMPDLNTSADTNTNNNNSNDANKPNDDPFASLGNPGGDSMDLDLDLDMAGAGDSVFDDMFFVDETNNLGGGDMEHGEFDNAFFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPZ0</accession>
    <name>A0A194XPZ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAS complex, SAS5 subunit/transcription initiation factor IID, subunit 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_729312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076167.1">
        <property type="nucleotide sequence ID" value="XM_018219368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPZ0"/>
    <dbReference type="FunCoup" id="A0A194XPZ0">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XPZ0"/>
    <dbReference type="GeneID" id="28829094"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729312"/>
    <dbReference type="InParanoid" id="A0A194XPZ0"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25850" checksum="4BA6251D8E4332F3" modified="2016-10-05" version="1">MVAEIKRTVKLITEQRNIDKPALQEGFPMKSWNIEVYMLDEMGNEKPATCFQKVVYNLHPSFENPIQTFTEPPFRCENEGWGEFDMTIDLFTTEKGGKNTLAHDLNFGKPRYEAKHTVSFKNPSAQLVNILRETGPVGDENGKKVKKESKSGGKKGIDMEKLAESLVKLNEDDLLHVVQMIHDNKSEDTYTKNDIEQGEFHVDLYTLPDTLVKMLWDFVHSPSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR29</accession>
    <name>A0A194XR29_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_680856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077100.1">
        <property type="nucleotide sequence ID" value="XM_018214155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR29"/>
    <dbReference type="STRING" id="149040.A0A194XR29"/>
    <dbReference type="GeneID" id="28823881"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680856"/>
    <dbReference type="InParanoid" id="A0A194XR29"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="24292" checksum="995A3E9025791680" modified="2016-10-05" version="1">MANYLASIFGTEADKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILLPNLYQNPAYDPKNKMNASQLQNHFDAFYEDFWCEMCKFGEIEEVVVCDNNNDHLIGNVYARFKYEDSAQKACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKNPSAELERELELSTKKWLRLRGRDERSMSRSPSPEPTRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRP9</accession>
    <name>A0A194XRP9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_312741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077223.1">
        <property type="nucleotide sequence ID" value="XM_018206644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRP9"/>
    <dbReference type="FunCoup" id="A0A194XRP9">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRP9"/>
    <dbReference type="GeneID" id="28816370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_312741"/>
    <dbReference type="InParanoid" id="A0A194XRP9"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="287" mass="32050" checksum="4E1133F91E890D74" modified="2016-10-05" version="1">MSLLPAERAQYSAIIDNILNKADLTTISRKKIMAELATTLGKDLSHQKEAVKSLILERFQIAETKAVKPAPSTEASTTNGHTSPLEREDINVKHESTPPSSRDVSTPSASITKTEPDSDSEEEAASPKKKRKANKPVDDDAKLAAMLQAQENRTARATRGGANKKTPKKVTKKPRKKSEKKVKADDDSELEEIGSDGEVKEKVKKGGFHKQYHLSAPLADLVGEATLSRPQVVKKIWAYIKERDLQDPKDRRQILCDERLQLVFKQDKVHMFTMNKILGKQLYDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRX9</accession>
    <name>A0A194XRX9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_574444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077303.1">
        <property type="nucleotide sequence ID" value="XM_018208742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRX9"/>
    <dbReference type="FunCoup" id="A0A194XRX9">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRX9"/>
    <dbReference type="GeneID" id="28818468"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574444"/>
    <dbReference type="InParanoid" id="A0A194XRX9"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="232"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ22948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="617" mass="67665" checksum="86CBB232DB532878" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRY3</accession>
    <name>A0A194XRY3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_713593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077410.1">
        <property type="nucleotide sequence ID" value="XM_018218063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRY3"/>
    <dbReference type="GeneID" id="28827789"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713593"/>
    <dbReference type="InParanoid" id="A0A194XRY3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="389" mass="41745" checksum="6C2D693CE7D1B8DF" modified="2016-10-05" version="1">MVEFCRLIFFFITKDLRPQYEEYDVSQFVNVKSASGYAVYGDNQHDDSAAINAILAANANCKITYFPQGIYKVTQTIYIPPGSRIVGDVLSVISGIGSNFYNPANPQPIVQVGRPGDVGVAEISDMLFSVADVLQGATIVEVNMAASSLGSVSFHNAHIRVGGTADTIVNQNCGNADTSDCKAAFMMPHVTSSAQPYIENMWGWTVDHSLDGGPNQNIATGRGALIESTKGAWLQTETAYWQGYGTAEQAPSPWTANSTIGGPTFSDCAGSGDSGNAQFYMGWASHIYSSSNIVIHGSALWVFFNDITDGSYSNAGCPQYNNVRQENAVYVDKASELFWYNLLTKSTTNMVWDNGVVTAAQVNNPGGWEGSVPGVIAAYLRDSGISSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT09</accession>
    <name>A0A194XT09_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_777876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077207.1">
        <property type="nucleotide sequence ID" value="XM_018222168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT09"/>
    <dbReference type="STRING" id="149040.A0A194XT09"/>
    <dbReference type="GeneID" id="28831894"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777876"/>
    <dbReference type="InParanoid" id="A0A194XT09"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ22852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="189" mass="20335" checksum="9B789E1743FD1FB8" modified="2016-10-05" version="1">MSENQPPAAAAGATGDIPGQPYYDKTRQHLRELLHKRKMLERSLAMQEETIYKKETDYLEDTPGGNIITGFESYTKGITNVAGGRRRGGVQEINRVFSRSSVTWNVNAESPMDTAQSTPVAAMAPTPLTTSFQKESGGGSNHATPTSATSANKSGGAGKKNKKGVNGDDSETEREGNKKIRTNFGAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTK6</accession>
    <name>A0A194XTK6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077898.1">
        <property type="nucleotide sequence ID" value="XM_018214041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTK6"/>
    <dbReference type="GeneID" id="28823767"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680282"/>
    <dbReference type="InParanoid" id="A0A194XTK6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268580" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8515" checksum="368C4B3DB79AC725" modified="2016-10-05" version="1">MSSLLLCVALWMFQAALSVIRTRSRPKLVSSSDASLVGFSSAYLCEKAWSLEHKDFIPLLGMHSQSCCIQASDYDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTX3</accession>
    <name>A0A194XTX3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_755618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078013.1">
        <property type="nucleotide sequence ID" value="XM_018221355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTX3"/>
    <dbReference type="GeneID" id="28831081"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_755618"/>
    <dbReference type="InParanoid" id="A0A194XTX3"/>
    <dbReference type="OrthoDB" id="10018600at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013040183" evidence="1">
        <location>
            <begin position="16"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="462" mass="48489" checksum="D90062A886D698C9" modified="2016-10-05" version="1">MLFSNLIFLVGTSLAAVSVTDPSDIISPSLWAADNAIIPDYNVSFISVQPNPIVAAYTVTNSASISYETLSTALNQTSVLLVTGELNLTYSTVIKSGYASNLLESSFYGFNAAINVVCFPSRFNGEANDQANGSTGNFDNVNVTVHNGAANIYVYGTGSVVHVDNAWLYSSGPVSHGVYASGNGTAYVSNVQHFSGGKRSSSFSGDSPAGYLHISDSVAHAAGIGSATFYALGEIYATNVVALSENGPTVFMDGAQKAYLTNCETTAGLLGGVAIFSSSTRESGAILSLDNSKITTLGPIPGLWFGNVIIDVSLHASELVTSGVLVVANYSQITQDFDYYADYSQQPNLQPAEVYVNVTESTLVGDLVAYNSSLISWSLSKSSWMGTAYSGFGEAYFDVHLDNSTWTLTNSTMVQNLTDTDGSLSGIESQGFDVYYNASALLNEYLGGKTIALSGGGNAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTX8</accession>
    <name>A0A194XTX8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_574215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078018.1">
        <property type="nucleotide sequence ID" value="XM_018208730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTX8"/>
    <dbReference type="STRING" id="149040.A0A194XTX8"/>
    <dbReference type="GeneID" id="28818456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574215"/>
    <dbReference type="InParanoid" id="A0A194XTX8"/>
    <dbReference type="OrthoDB" id="3202072at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="109" mass="12171" checksum="3106F752B6EB6ACC" modified="2016-10-05" version="1" fragment="single">QVVVIMATSEGKSLLFILPCILPNARVTILVLPLVSLRGDLLHRVRELGIDHLVWAPSEQQDAPLVFIIVKAVCTEQFRTYAHKLAATQDLGRIVFNEAHLTIIASDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU63</accession>
    <name>A0A194XU63_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_680032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077602.1">
        <property type="nucleotide sequence ID" value="XM_018213996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU63"/>
    <dbReference type="FunCoup" id="A0A194XU63">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XU63"/>
    <dbReference type="GeneID" id="28823722"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680032"/>
    <dbReference type="InParanoid" id="A0A194XU63"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ23247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="17843" checksum="5959D2ECA4654077" modified="2016-10-05" version="1">MRTYDDTFSGEKIYPGKGKLYVRGDSKIFRFQNGKTESLFLQRKNPRRIAWTVLFRRQHKKGISEEVAKKRSRRTVKSQRAIVGASLDVIKERRTQRPEARSAARLEAIKAGKEKRAAAQSAKKAEKAKSAAGAAKGQATRLTSKQGAKGAPKKVQATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUH6</accession>
    <name>A0A194XUH6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078044.1">
        <property type="nucleotide sequence ID" value="XM_018213796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUH6"/>
    <dbReference type="GeneID" id="28823522"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679030"/>
    <dbReference type="InParanoid" id="A0A194XUH6"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268623" evidence="1">
        <location>
            <begin position="24"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="416"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="540" mass="59115" checksum="019522F434EC2BE1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUM4</accession>
    <name>A0A194XUM4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_604339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078375.1">
        <property type="nucleotide sequence ID" value="XM_018210353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUM4"/>
    <dbReference type="STRING" id="149040.A0A194XUM4"/>
    <dbReference type="GeneID" id="28820079"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604339"/>
    <dbReference type="InParanoid" id="A0A194XUM4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="336"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="550" mass="62048" checksum="27A6DC8E6A2E83F3" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVK2</accession>
    <name>A0A194XVK2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_16726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078618.1">
        <property type="nucleotide sequence ID" value="XM_018205540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVK2"/>
    <dbReference type="GeneID" id="28815266"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_16726"/>
    <dbReference type="InParanoid" id="A0A194XVK2"/>
    <dbReference type="OrthoDB" id="3563877at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="194" mass="21822" checksum="F0DB0FB3F011CD79" modified="2016-10-05" version="1">MSKISFTIALPHDGPNGNRTPQFFISTSNNTYLSFKGMDYKGARFGNSNATSGWKNRFEYSVVAAKGITKFSIQMNTSVILPPLSWGLPGPAPKAKKEEKEKRKSKSNGSSRGTSSSKSSSSRSSRSSYDSREGPRRSGKRHEQPRLRDHSPPRRLRDIEDQAYRKHGQRRRRESTREHSPGVVDHLDPFDPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVQ2</accession>
    <name>A0A194XVQ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_703304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078439.1">
        <property type="nucleotide sequence ID" value="XM_018217311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVQ2"/>
    <dbReference type="FunCoup" id="A0A194XVQ2">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XVQ2"/>
    <dbReference type="GeneID" id="28827037"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703304"/>
    <dbReference type="InParanoid" id="A0A194XVQ2"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ24084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="120" mass="13259" checksum="83A467B4144B6733" modified="2016-10-05" version="1">MLTERELQISPTVQESVLHNTKVLTTLHNLTASLFGVGAGILGLESYPGFLFYFLFSLLTSVLVYAFRVRPGIIKEAQSSGSSGMQRYFRGSMELWTGGLIEGLSGFVLTWTLFYGLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW02</accession>
    <name>A0A194XW02_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_679565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078768.1">
        <property type="nucleotide sequence ID" value="XM_018213894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW02"/>
    <dbReference type="FunCoup" id="A0A194XW02">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="GeneID" id="28823620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679565"/>
    <dbReference type="InParanoid" id="A0A194XW02"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ24413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="528" mass="57389" checksum="F1E79D7A94598CB0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWX1</accession>
    <name>A0A194XWX1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_776399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078607.1">
        <property type="nucleotide sequence ID" value="XM_018222040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWX1"/>
    <dbReference type="GeneID" id="28831766"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776399"/>
    <dbReference type="InParanoid" id="A0A194XWX1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="2">
        <location>
            <begin position="116"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="37702" checksum="ABFC2B3EBFA55F51" modified="2016-10-05" version="1">MSPASELPILLYHLGSPLSKRIIWYLALRGIPYIQCMQPRILPRPDLARLGINYRRIPILSIGRDVYLDTRLILQKLEHLHPSKPRLAALATPEHRAIEHLLEVLAIDSGLFKSVVQLMPAHLPQLQDPAFLRDRADLLEGMMVFTPEALTAARPNAINEVKNVVEFLETTLLADGRDWVLGTHGPSIADIEAVWLLHWISAVPGALPPDQISGVLYPRVFSWIERFQRTVSSAEKLISAPQTVDGEQAMEIIVTSLFNETEGLVDENDPVVKQQGLEKGQFVQLWPTDSGSRHKDNGKLVSMDNKEVVIETAAGDAVVRVHAPRHGFQVCAFEDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWZ3</accession>
    <name>A0A194XWZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_727319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078642.1">
        <property type="nucleotide sequence ID" value="XM_018219139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWZ3"/>
    <dbReference type="FunCoup" id="A0A194XWZ3">
        <property type="interactions" value="954"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWZ3"/>
    <dbReference type="GeneID" id="28828865"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727319"/>
    <dbReference type="InParanoid" id="A0A194XWZ3"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180007">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032215">
        <property type="term" value="P:positive regulation of telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28420" checksum="290BEC76BD91F2C5" modified="2016-10-05" version="1">MAQPQTQAGSANGTSNGERQDPGGFKLKFCTVCASNQNRSMESHLRLAAANYPVISFGTGSLVRLPGPSIDKPNVYQFNKTSYDSMYKELESKDPRLYRANGLLNMLERNRGVKWGPERWQDWQIGAPRLQHNADRGSEGLEGGVPDVVITCEERCWDAVIDNLLERGSPLNRPVHVINVDIKDNHEEALIGGRGILDLADSLNKAATEEREANPSGFDSGIAGSRAGFDERVPEIIGEWQERWPNLPSVWTLGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B242</accession>
    <name>A0A132B242_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_632868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060823.1">
        <property type="nucleotide sequence ID" value="XM_018211319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B242"/>
    <dbReference type="FunCoup" id="A0A132B242">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B242"/>
    <dbReference type="GeneID" id="28821045"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632868"/>
    <dbReference type="InParanoid" id="A0A132B242"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
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    </dbReference>
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        <property type="term" value="P:meiotic centromere clustering"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="Stu2_CTS"/>
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    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
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        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
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    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="275"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="827"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="900" mass="97417" checksum="5616A5D88FA34F29" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2S6</accession>
    <name>A0A132B2S6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_403835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207281.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Elem"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="720" mass="80096" checksum="47B37067165DB12B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B334</accession>
    <name>A0A132B334_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_692166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061161.1">
        <property type="nucleotide sequence ID" value="XM_018216479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B334"/>
    <dbReference type="STRING" id="149040.A0A132B334"/>
    <dbReference type="GeneID" id="28826205"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692166"/>
    <dbReference type="InParanoid" id="A0A132B334"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
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            <end position="57"/>
        </location>
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            <end position="91"/>
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    </feature>
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        <location>
            <position position="490"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:30413"/>
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        <ligandPart>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ06806.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="546" mass="61461" checksum="506A1890B0CDF714" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3U5</accession>
    <name>A0A132B3U5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_661946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060949.1">
        <property type="nucleotide sequence ID" value="XM_018212627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3U5"/>
    <dbReference type="GeneID" id="28822353"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661946"/>
    <dbReference type="InParanoid" id="A0A132B3U5"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
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    </dbReference>
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        <property type="entry name" value="AATase"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58898" checksum="C3843F192293E599" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4P0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_660975</name>
    </gene>
    <organism evidence="8 9">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4P0"/>
    <dbReference type="GeneID" id="28822303"/>
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    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="531" mass="58435" checksum="0CDD6D201F2E962B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4P2</accession>
    <name>A0A132B4P2_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">Complex I intermediate-associated protein-like protein CIA30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_789821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061733.1">
        <property type="nucleotide sequence ID" value="XM_018223301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4P2"/>
    <dbReference type="STRING" id="149040.A0A132B4P2"/>
    <dbReference type="GeneID" id="28833027"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789821"/>
    <dbReference type="InParanoid" id="A0A132B4P2"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="44"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="30501" checksum="A42D26FE8C1B9FFD" modified="2016-05-11" version="1">MRVTPNPLAKGFFGRSVDELKRLSGIALRAEGTRRATNPYVLHTFHEPDSPESCKLMSDGDVGGFSRAHLDWIPPATSLHPLPSENNKGYAKFHGSISIELPADKPHIQRTGYAAWRTKDRPPTVFGKSLWDIDPYAFLALRIKSDGRKYFVNLQTESIVPTDLHQHRLYARRPGEWETVLIKWNEFVRTNHGVVVEPQTELLRQKVRTVGIGLIDRIPGKFELCIERIWATNELGEEYLKEDDRIEEGQLKSKHGEKIRWNEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4Z3</accession>
    <name>A0A132B4Z3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061668.1">
        <property type="nucleotide sequence ID" value="XM_018216405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4Z3"/>
    <dbReference type="GeneID" id="28826131"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691776"/>
    <dbReference type="InParanoid" id="A0A132B4Z3"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="14845" checksum="B335308AD669CBC3" modified="2016-05-11" version="1">MDLRFEAASLDAVVGFYSLIHLPREEQGVLLKRIWEWLKDGGLLLVNLSVGDSEEMSNGDWLGSGKKMFWSAWDEKGNTEMIKRAGFKVLEGEVISDTEDGREVKFHWLLTSKGGGCRPETIDERGVQWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B550</accession>
    <name>A0A132B550_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061369.1">
        <property type="nucleotide sequence ID" value="XM_018220941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B550"/>
    <dbReference type="GeneID" id="28830667"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743341"/>
    <dbReference type="InParanoid" id="A0A132B550"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="17316" checksum="54A5376AA51ABCF2" modified="2016-05-11" version="1">MTVSAALGTNPEMSTEQSTSSGALEETLDFGSDQDNLLGPIEQTEGNVFHHIPYSSQSPSSTKDGPQLMERLSPSRFLFSRAIRGNKYNNQHCKIPGEHIPDTSQSNIPHLHRNPQFPARRRCELVYGTRAATSFFTITVALRSPHPNCTNSTNDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B552</accession>
    <name>A0A132B552_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_601220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061887.1">
        <property type="nucleotide sequence ID" value="XM_018210190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B552"/>
    <dbReference type="FunCoup" id="A0A132B552">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="GeneID" id="28819916"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601220"/>
    <dbReference type="InParanoid" id="A0A132B552"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="498" mass="54718" checksum="5D5B94D1FA3C42F4" modified="2016-05-11" version="1">MDDKPYSVFTHNEKKIIVICAGLCQFFSPISGQIYFPSLDAIAHDLHVSYSLVNLSITTYLIMQGIAPAFVGGFSDSSGRRPTYLVCFIIYMAANIGLGVQNNYAALMVLRMLQSAGGSGTVALSNAVVSDIVTSQERGTYISYISIAPQAGPSLGPIIGGLLGQYLGWHSIFWFLLICTGVILIPVALFFPETCRKVVDDGLIPPPKWSRCYMNTWIEKRLIGEGNAIPYEKRDELARKRKIRVPNPLETVKIVFTKEAGFILGYIGIVCCTYYATIALLPSQFGTVYGFNQIQIALCYLPLGCGSLLASLVRGRIIDSRYKVHAKRLNMPLEYNRRVDLSNFPIERVRLEVAVPTLALGTACTIGFRWMIQYKVNLSGPLIFLFVIGFCTSSSLNIVAVLLIDIYPGSAGSAAAANNLVRCWLGAGATSGVVPMINKIGIGWTTTFFGLLNVVFAPILWYVMKNGPKWRRATKKRKEREQAKRDAKTDVGGEKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5S6</accession>
    <name>A0A132B5S6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_789440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062107.1">
        <property type="nucleotide sequence ID" value="XM_018223255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5S6"/>
    <dbReference type="GeneID" id="28832981"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789440"/>
    <dbReference type="InParanoid" id="A0A132B5S6"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="371" mass="41702" checksum="01F35B8339147797" modified="2016-05-11" version="1">MATAAAKQYNGSWFSYASPGEIFAASTVLPFLGIKMSLDDWLIILALLMLIIVAVFMLIGIAKHQIGYSTLKYALTESFSLIDKLTYFLQLFLIISNGFIKLSVLFFYRRLLIVDKRGVFSWVTFVAVAIIFLWTLAYLFTFIFGCGLHMSAYWGSLQGVEKYYGKGGFTIERSFYISDFVTDVMILCLPMPMIWRLRIGTAKRFAVTGIFLLGAMSLAASIARMAMYEEVYRRSFTDLASTEDRHLTSSTILYWSIIECSLALIAACLPILQVFFKGISLPAVIRSVRSVVSLHSLQSQNTQNSTTVGRVNAYSESGRTKLESTDGMHLPHLGEFLSMNNSTTGKYDGSEVLEPGRVYFQESMRTEHFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6A6</accession>
    <name>A0A132B6A6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062295.1">
        <property type="nucleotide sequence ID" value="XM_018220802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6A6"/>
    <dbReference type="GeneID" id="28830528"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742239"/>
    <dbReference type="InParanoid" id="A0A132B6A6"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="29000" checksum="397DDA2297ACF5EB" modified="2016-05-11" version="1">MSKALDTRRLADAPFKLIETPAHAQKSSKPYDQYVEAASVMALGHNVFIRGMNSIYKQAPHIKPEDHADFINYAKCWAEILDAHHKMEETSLFPQIEAKTGEIGIMEVSVEQHHAFLPGLAAYKEYLSGCTNKPDTFSGTRLISIIDSFAPELLIHLSDEIPTLLALSKFGNQLRLLDMVNAESQKSPLHQSITGGTPFFFRNLDVEFEDGIWKQWPPIPAPVWWFLQNSFVAWNSRWWRFAGCDASGKLRELPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6B1</accession>
    <name>A0A132B6B1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_352782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062148.1">
        <property type="nucleotide sequence ID" value="XM_018206937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6B1"/>
    <dbReference type="GeneID" id="28816663"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_352782"/>
    <dbReference type="InParanoid" id="A0A132B6B1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10765" checksum="139531E4F8CB915F" modified="2016-05-11" version="1">MSIISSRRRHKVDSMVAFGGTIPLSLGFSCYTTWSFLSLLPLLSEFYSREQTVHRCSCILNSGRELSRDEHLRIWKILLGLHSAQSGTVYTINTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6D6</accession>
    <name>A0A132B6D6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_765979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062256.1">
        <property type="nucleotide sequence ID" value="XM_018221701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6D6"/>
    <dbReference type="GeneID" id="28831427"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765979"/>
    <dbReference type="InParanoid" id="A0A132B6D6"/>
    <dbReference type="OrthoDB" id="10675601at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="57019" checksum="93D4C8A1C8681DD9" modified="2016-05-11" version="1">MSKYCKLGPVLDEQARQAGYPPGHAEEMRIAIRNITMPRHKAILKDELNLPLTNKHIDWYGWKHLFPPGNPAFPVSEPQRAKGHAVLLAAFENMGLPSDPNGINTSTLLLAGPPDLTTNPIGSTLSAHGRGGHFGGSNRPRPIPHSTILGISPSDNEHRQKQQPQQTASRGRGGSRGGRGGGMVPTHSSHATDRRHLHWPWRDESGDIEFEIPIYTVFKCYLYGADRKSISAVEGYFKVTIEGEYPVADDKIFFHIWVQAQEKVQSESPPYHRAQSAYAFLLEYEKQLRWGYKRNGLSPYIDDFLFEYNQKGYVTVPDRIFAEVTKHTASSSLNAGPQYHQGVTLEPQTSGPSLANNNNTNTATVSPTAPTAPKGNKRKWEYFVEATETQSEASKIDAQKEIKRRLVDEEVTGRLMLSKDHMLSQVDKAVAKLRFIMMEVFDNLPVGHSFFAQYSQLLAQDGGNFQKTGSGQESPPERAEGEKKIIEEGLNTDDHMDSDEELRWYGLAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6H5</accession>
    <name>A0A132B6H5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061632.1">
        <property type="nucleotide sequence ID" value="XM_018216401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6H5"/>
    <dbReference type="FunCoup" id="A0A132B6H5">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6H5"/>
    <dbReference type="GeneID" id="28826127"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691752"/>
    <dbReference type="InParanoid" id="A0A132B6H5"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="43111" checksum="4D3A9A01560C688B" modified="2016-05-11" version="1">MEDHEKFREWVTERGVKIDGITAHKFEGRGVGIIAEKRLKADSTILTVPISALRTAHTLPKALQPLLKSAPTIHGILALMLALDTSPTYQLWCAVLPTASDFESTMPLHYPSSLQDLLPSASKALLAHQKSKLKADWAFASSHYPKLTYDDYLYAWLLVNTRTFYFLPPGTKTPKNHDDCMALNPFADYFNHTSRGCHVSFTAEGYKVMTNKVYEKGEEVFISYGNHSNDFLLAEYGFILPSSEEPGGNEWDVVSLDDYILPLLSAEKKELLKESGFLGNYVLDNAEVCYRTQVALRAQCLSTRKWQRFMDGSDDGADDQEAVNEVLLKALKRYHKDTEKYFKQVSATKEGEESHRDMLSRRWKQISNLLQREIDRIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6P9</accession>
    <name>A0A132B6P9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_711852</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062441.1">
        <property type="nucleotide sequence ID" value="XM_018217931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6P9"/>
    <dbReference type="STRING" id="149040.A0A132B6P9"/>
    <dbReference type="GeneID" id="28827657"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711852"/>
    <dbReference type="InParanoid" id="A0A132B6P9"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ08086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="422" mass="46096" checksum="8CEFCF5069F7D6B5" modified="2016-05-11" version="1">MFTETSSVMSVGGIEIPSLNGKTCTVHALGALQDDVPNILSAFTTCNNGGTIIFPSTENYYIASQLHPILSHVTIEWRGTWTLSDNLTHWRDTNNTIPIHFQNHHAQFTISGDHIHIHGHDTGRLDVNGNAWYDAEQAVTQPVRPMNFVWWNASEVLVEHFSVIDPPLWSINLMNVSNAWFHDIYVNATAVNAPYDALWVQNTDGFDTLDCNNVKLTNFVYQGGDDCIAIKPRSYNTYVQNVTCHGGNGIAIGSLGQYQEDSSVINAWIKDVNILIRNTDMHNSAYIKTWMGASLPQSSYNSAGLPNGGGWGVVQNLRFENFWVQGAALGPSITQDNGDNGSYAGTSKMEISNIAFVNFTGYTLATSNETASISCSNVHPCFNIALQNVTLAPSKNGTEVEAYGSCDYTAKNGVTGMIGHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B748</accession>
    <name>A0A132B748_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_338423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062593.1">
        <property type="nucleotide sequence ID" value="XM_018206841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B748"/>
    <dbReference type="GeneID" id="28816567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_338423"/>
    <dbReference type="InParanoid" id="A0A132B748"/>
    <dbReference type="OrthoDB" id="4148174at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287948" evidence="1">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="297" mass="31880" checksum="981349FC750F860F" modified="2016-05-11" version="1">MFSILNYTTLFLTLLPLLSLTDAQSSISSSNSTGYTGYNLTLSSDPESVTYDTEDTPANVSTTYPAPDVYLNASVHIGEIDILVANLSAKINLDAQVLNLLTFNAGVDLSIDRVSLTIQNVTAKVLLEARLENLVLMIDDILHSLDLNPVLATLGQDLTNITNTTVGALTGATSSLKRSVPYDLAHNVLFSSNDYSGNTHKNRILEQNGDIVDQYLDNDGNIRAQTTVGTYLKDMTFNGENVTVTLGGKPAQKLEFVYEPFNGLSVVSFVWVGGAGEVLGTQVLSERFAGGESTIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B980</accession>
    <name>A0A132B980_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_599289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063168.1">
        <property type="nucleotide sequence ID" value="XM_018210083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B980"/>
    <dbReference type="GeneID" id="28819809"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599289"/>
    <dbReference type="InParanoid" id="A0A132B980"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288017" description="NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="148" mass="15945" checksum="DE09044EE76D9A1A" modified="2016-05-11" version="1" fragment="single">IMAEAFGIAAGVIGVVSLSIQLADGVQKACDFCESIEDGPEDIERISAELRLLSNCLQLISHEHQSGMADPSQDSLVLSALRIAKKDINELSVFVTELTSKINPGQGKVKRKWGRVKIALSAAKIAKMKTHVESAKSTLNMLQASRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA12</accession>
    <name>A0A132BA12_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic mitochondrial regulator protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_598310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063597.1">
        <property type="nucleotide sequence ID" value="XM_018210033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA12"/>
    <dbReference type="FunCoup" id="A0A132BA12">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BA12"/>
    <dbReference type="GeneID" id="28819759"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598310"/>
    <dbReference type="InParanoid" id="A0A132BA12"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36014" checksum="AF9CF47F55D75C7B" modified="2016-05-11" version="1">MGAYNREGQLTRVVKASREQERERNSGGGSNESTQQRQPSDPNNPDGADNPDGTKAATLPPESRRDLTPFPLDPQFISQPVLSGWFKDQIWKQVILQGLSVREVSASLGVEMSRVAAVVRLVEIEKEWKRINKPLMRQYHQAVMNMLPKTLWNPEETTEENRKKTKTHESINDLPVHVATGQQIFLPTSESRHFTRKDAARVFDAKLLPADDRVPHPELAVMHKEVLEELSDEERKARAEARDASEEQKRKVALARQAKKEASIKKVDIGRFEYRFSEIKVDDAGKDGRGLKGVGWRYGVPLMDRSRGQHKIPRAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAK3</accession>
    <name>A0A132BAK3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative estradiol 17 beta-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_762071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063797.1">
        <property type="nucleotide sequence ID" value="XM_018221565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAK3"/>
    <dbReference type="GeneID" id="28831291"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_762071"/>
    <dbReference type="InParanoid" id="A0A132BAK3"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF86">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="34831" checksum="772BAC82F88359C0" modified="2016-05-11" version="1">MAQITFNPDLLSTLKDKIVVLTGGATGIGLEAVKQFHQAGAKIAFGDIATSLGQQLANSFSSDRILFQHCDTSSYTSQLSLFKLAHSTWGRIDIVVANAGISIPQDPFEADQDVEKEFSTREIDVNLRGALYTTRIGCHYLRKNGKEGGDLVLVSSIAGFKESTGLTVYTASKHGVLGILRGLRVQVAREGIRVNGVCPWMTKTGMVKGIESGWRDLGLPENKPEDVARAIVICATANRAKAKYDTHTLSTSRKTHSGAKTPFWGKILFVSGGESYEIEDNYDRLEPEWLGVENSEVLKKGQDFLMNGETSWDTTKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBB5</accession>
    <name>A0A132BBB5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_675735</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063918.1">
        <property type="nucleotide sequence ID" value="XM_018213533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBB5"/>
    <dbReference type="FunCoup" id="A0A132BBB5">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BBB5"/>
    <dbReference type="GeneID" id="28823259"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675735"/>
    <dbReference type="InParanoid" id="A0A132BBB5"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288093" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ09563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="450" mass="48487" checksum="59EFC34380264462" modified="2016-05-11" version="1">MRIRSHHVGVVCLLANFGDAAITLDLTSTDSIKKAASTVAFDLMKYYTGNNTGDVPGNLPDPYYWWEAGAMFGTMINYWYYTGDTTYNAVTKQALLHQAGDDGDYMPLNQTKTEGNDDQGFWGMAAMTAAETKFEDPPSGQPGWLALAQGVFNTQAARWDTSTCAGGLRWQIFTFNNGYNYKNSISNGCFFNLAARLALYTGNSTYSDWAVKTFDWMYGVGLMSPEYKIFDGTQNTDNCTAKDHNTWTYNAGIFLLGSATMYNYTNGSAIWQERVTGLLNASLVFFTDGVMYEPCESSKCNIDQRSFKAYFSRWLAATAEIAPFTHDTIMEKLASSATAAVKTCTAGNTGTQCGLRWTTGANDGSLGVGEQMAVLEIVQSNLVDTAPGWVSAVKGTGTSEGDVNAGSDSSSTADDLLVTPVTMGDRVGAGFLTALVLIGVVGGSATMIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCP8</accession>
    <name>A0A132BCP8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_701112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064557.1">
        <property type="nucleotide sequence ID" value="XM_018217170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCP8"/>
    <dbReference type="GeneID" id="28826896"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701112"/>
    <dbReference type="InParanoid" id="A0A132BCP8"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="314" mass="35342" checksum="5B4EC1F59D0ADB4D" modified="2016-05-11" version="1">MPHKHVRRGEVDKSTVDLPPTSVAEPLPVSKSAKSNGIFTTEINAKRNNKKRKRKDDKDDTPKAFARLMAFAQGKKLPKGLDDGVKETKAAKKRRVAAAAENEKEESAKVEEPRGEVPSIRPGERMSDFSARVDAALPVSGLINKSTRGGKDPLGLKVGRTKTEKRMHRMYDEWRQEEARRQEKRQEALELAEEEEMDEDGQVKWKVDVEKNGKKKKGKKRKVLGEVEDGDDDPWAKIKRDRGEVKAGLNEVVLAPPTFSKIPKEKFKIRGGARVEIDDVPKASGSLRRREELGEVRKGVVEGYRQMMKEKSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCV7</accession>
    <name>A0A132BCV7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 alkane hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_272139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064556.1">
        <property type="nucleotide sequence ID" value="XM_018206374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCV7"/>
    <dbReference type="STRING" id="149040.A0A132BCV7"/>
    <dbReference type="GeneID" id="28816100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_272139"/>
    <dbReference type="InParanoid" id="A0A132BCV7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="57754" checksum="C6349DE9614D8D7B" modified="2016-05-11" version="1">MAISILSTLLSSIVFLTCYILWKKVLISSASSKAGCSSPIKYNHLDPFFGLDLFIRKIRYTQVGDLLALDDEIFAKYGKTVHTLFFGANHWMTMDPLMIQAVAATEADKFGNEPTNRKSCGPLLGDGAFTVDGALWKRSRDIINPIFSRSQVSQLSSLKIHIQRFMEHIPRDGSTIDIQPLTKMLFLDSSTEFIFGKSAGSLTECELTIGAQKFSEAFDEGLRGMRKNYMTGQFSWLIGTDKKWLEKCSEIHAVVDGYIEEEIEYQRSTKEMGLSTDTPSESSAYKYVLLRELVKNHSDDKLYIRSELMNVFFAARDSVGTVTANMIFHLARSPGVWQKLRKEVGGIASNQELTFEFLKSLKYVQAVIEETLRLVHPVDRCWRTCLSPCILPRGGGNSGREPILLQPGDQIELVYGSMHKDKDIWGEDASSFVPERMLGLKHSWQYIPFMGGRRTCPGQQNAYTDMAFFLVKMVQEFKTIENRDDCLEYVEEYVMTKESRNGVKVAFTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDA0</accession>
    <name>A0A132BDA0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_689522</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064588.1">
        <property type="nucleotide sequence ID" value="XM_018215920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDA0"/>
    <dbReference type="FunCoup" id="A0A132BDA0">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BDA0"/>
    <dbReference type="GeneID" id="28825646"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689522"/>
    <dbReference type="InParanoid" id="A0A132BDA0"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
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    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ACONITASE"/>
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        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LeuD/IlvD-like"/>
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        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="539"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KUJ10233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="775" mass="84454" checksum="9DAF24A3B02E7B0B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDJ8</accession>
    <name>A0A132BDJ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_627997</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ09747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDJ8"/>
    <dbReference type="GeneID" id="28820891"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_627997"/>
    <dbReference type="InParanoid" id="A0A132BDJ8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="56353" checksum="8F8BD726C9731745" modified="2016-05-11" version="1">MASVISYLKSEWRAILICCFICIGAFQFGYDSSYFSGILAMPEFLMDYGSKDPATGEYMLSAGKQSLVTSIINAGEFVGAVSSYYIGSKIGRKGGLYVSSVCVVAGVIFQVSAPHEGLLIAGRLVLGFAVGLISCFIPLYVADCAPARVRGALVSMYQYVIGLGLILGVIIDNSTKDHTNTGAYRIPMAVQLIFPMILVSGLLLFAPESPRWLIEKNRPTKAEQSLRRLHGNDAEKIQQEMEMIHQTIETYNDGRESSWKDVFTWGPEGRKAYLGFALQAFQQASGINFITGYGIVFFIQIGIDNPFIIQLGLYLVAMPAIWISQYSIERFGRRPIILISGGLMAATSIIMGACGLTKEKSYALDQAIVAMVYIFLVVFNLGWGPTVWVLTSEISTGKNRGKLMSFSTGTNWLFTWLVSFTFPYLFNADAADLGAKVGFIYGSLMVAACVWTYFLLPETAGRSLEELHLMFEMGLPARRFKSYVFPEIPMDMAKKDLTVVQVEGNSKFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDW8</accession>
    <name>A0A132BDW8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_740289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064936.1">
        <property type="nucleotide sequence ID" value="XM_018220572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDW8"/>
    <dbReference type="GeneID" id="28830298"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740289"/>
    <dbReference type="InParanoid" id="A0A132BDW8"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <begin position="133"/>
            <end position="153"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="159"/>
            <end position="177"/>
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        <location>
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            <end position="422"/>
        </location>
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        <location>
            <begin position="419"/>
            <end position="544"/>
        </location>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="580"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="28"/>
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        <location>
            <begin position="54"/>
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        <location>
            <begin position="580"/>
            <end position="600"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="975" mass="109217" checksum="3F44EB95897A717C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE25</accession>
    <name>A0A132BE25_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_255139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206231.1"/>
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    <dbReference type="GeneID" id="28815957"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_255139"/>
    <dbReference type="InParanoid" id="A0A132BE25"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13790" checksum="5DF641845132440A" modified="2016-05-11" version="1">MRVECVFLRLVSLIVHSLTYSLPLTICFTTLLLLCHHCFCSRGDPDSGCICSLPFFLLSFRHKKALFLSPYRDGILHISRPRPMLCILPTIHSLHEVLLYDLSFSTRDSIAHHLLRIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSD1</accession>
    <name>A0A194WSD1_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_700567</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064959.1">
        <property type="nucleotide sequence ID" value="XM_018217131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSD1"/>
    <dbReference type="FunCoup" id="A0A194WSD1">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="GeneID" id="28826857"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700567"/>
    <dbReference type="InParanoid" id="A0A194WSD1"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="20">
        <location>
            <begin position="631"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="988" mass="108626" checksum="2E7D24F9D7A93E14" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSI7</accession>
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            <fullName evidence="3">Ubiquinol-cytochrome-c reductase complex assembly factor 2</fullName>
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        <name evidence="1" type="ORF">LY89DRAFT_247911</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ10649.1"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
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    </dbReference>
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        <property type="entry name" value="UQCC2_CBP6"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15310" checksum="885E64E2E0D71F1F" modified="2016-10-05" version="1">MSKSIAYKHYIRALSRWPKDNLRPDCQFQDVMRKRLDRRFIPASSPNTPNAAQAVANSAIDEKMELEQANAIYSLLENRYSRKYPIDGSLMRPASNPTHFEDLMKELQEAPERSWWGSMTNRWKGFLRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSZ7</accession>
    <name>A0A194WSZ7_MOLSC</name>
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        <submittedName>
            <fullName evidence="13">VHS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_595638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209872.1"/>
    </dbReference>
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        <property type="interactions" value="819"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WSZ7"/>
    <dbReference type="GeneID" id="28819598"/>
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    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:Golgi to vacuole transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="179"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="520"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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        </location>
    </feature>
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        <location>
            <begin position="425"/>
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        </location>
    </feature>
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        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="640" mass="69379" checksum="EEB4E59379B16DAE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTI2</accession>
    <name>A0A194WTI2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_786877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3564122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="505" mass="55541" checksum="19280AFC58E8CFCF" modified="2016-10-05" version="1">MSRRLRSQEKMFLFLLFTFCVFELSFPNIYDSRTNVPEMLITRLQAFAFWIAALVSARQGQLPTTTSFLPASSEAFICKAGSCAYNVVASSIRGIPPAITTNDPKDKVPSITNYPYHPGKRSSRVTRVGTVKRVDEEDPTIIRQRDFTDPNTFLTGTKAQWFQHAVGLVESSGPQRIETPTGGIPSSTWFDYSDLRNHAITTGTGPSWGCTSVLVFSERGVWMAHFWEQEQIQNSTTFDSDVLNFLRIGSGDGIHQGLVDVVDWLFNGSIPEDIGESLEEPLFSAAVIFTPSYRDSQKVPEGAKAADPIYGDQIKKIKALLIDQLPAFTDQNIQVATYKPVNSAAEMEAQPWLGLMTFEYAPQHLRKTDDGQCIVSRALRIWNQDEILGVYPYTWPQSLPTASGLPDIQLRSKQVDIGACPADVSGILKSQGNGAYEPQFVFGLNAPATTIPTSTTASTIQPTPPPTLPDSDYMCSSWQLSPNGVQVGSDCGGDPNKVVTVTVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUJ0</accession>
    <name>A0A194WUJ0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_241035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065632.1">
        <property type="nucleotide sequence ID" value="XM_018206112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUJ0"/>
    <dbReference type="STRING" id="149040.A0A194WUJ0"/>
    <dbReference type="GeneID" id="28815838"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_241035"/>
    <dbReference type="InParanoid" id="A0A194WUJ0"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58470" checksum="59AE7CE61A31C736" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV40</accession>
    <name>A0A194WV40_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI anchored cell wall protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066191.1">
        <property type="nucleotide sequence ID" value="XM_018215688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV40"/>
    <dbReference type="STRING" id="149040.A0A194WV40"/>
    <dbReference type="GeneID" id="28825414"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688342"/>
    <dbReference type="InParanoid" id="A0A194WV40"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="1">
        <location>
            <begin position="202"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="37285" checksum="486CCB011F3F6B1A" modified="2016-10-05" version="1">MVAIKHIAAKLAAGAALFPRQNTPCSFVMNAVGDPNGMVVEDTIGENRIGGGYPQGNYYMEGHALYDALNHPCVIEPGSYQFLCTQGGGGLANFSLAADGNLMHDSCENFLACPATGPGEDGSWNIFSDALQNTTGCETVTLRTGGFNCTALGRPDPTTSATASATGTATGTATGTATTLPTVTPLAPAAACPTDLSQGTFQFPHLIVPTSSQDGDHAFGNSLKAYISPINTTLYNFDIPATYNGTCALVFLFPYQTDLDPSAGGYTFSGTEEEVGEHGGIDFALLSGIASAATTFNSTPAVATDYGKTQIIPGNNYTVATYPCQAGTTISYSATSVGNVELDYFQDSAPMPIGLYVVPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVS7</accession>
    <name>A0A194WVS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-containing amine oxidasedehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_625310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066134.1">
        <property type="nucleotide sequence ID" value="XM_018211071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVS7"/>
    <dbReference type="STRING" id="149040.A0A194WVS7"/>
    <dbReference type="GeneID" id="28820797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_625310"/>
    <dbReference type="InParanoid" id="A0A194WVS7"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="61099" checksum="0F11764059E32453" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW58</accession>
    <name>A0A194WW58_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066556.1">
        <property type="nucleotide sequence ID" value="XM_018215747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW58"/>
    <dbReference type="GeneID" id="28825473"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688653"/>
    <dbReference type="InParanoid" id="A0A194WW58"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="70"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="21296" checksum="904FD46470F553FE" modified="2016-10-05" version="1">MTPTLRRQLSTLFQNDSRTLPTQKSSKLLSLPFELRTLIFSVCLSNHTIHLFLYSPFNRLKWHHPSSSDDQPPILPLLLSCRQIYIETTPLLYTTNRIKFTLPLTISSQCLNRLLPPHRGPQIRDLWFQWHVQLTPKKDSPEHEEWRKVWEALAEFKGLRRLWVDIVPIWADRWAEEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWB9</accession>
    <name>A0A194WWB9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_593392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209746.1"/>
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    <dbReference type="OrthoDB" id="4412445at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="76" mass="7906" checksum="6E28F1FCE75376AD" modified="2016-10-05" version="1">MSGLPIPWVCFQCGTDQNPCHCKVIGPTLGFGVAIVLAVICWPASLFCGCCATERGKKMLGAPVEISGQVSNAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWC7</accession>
    <name>A0A194WWC7_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220381.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_738523"/>
    <dbReference type="InParanoid" id="A0A194WWC7"/>
    <dbReference type="OrthoDB" id="5287295at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="517" mass="57161" checksum="C44B5C0C3AEB7393" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWH4</accession>
    <name>A0A194WWH4_MOLSC</name>
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        <submittedName>
            <fullName evidence="9">Apses-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_699931</name>
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    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066282.1">
        <property type="nucleotide sequence ID" value="XM_018217091.1"/>
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    <dbReference type="STRING" id="149040.A0A194WWH4"/>
    <dbReference type="GeneID" id="28826817"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699931"/>
    <dbReference type="InParanoid" id="A0A194WWH4"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ascospore maturation 1 protein"/>
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    </dbReference>
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        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG1/Phd1/StuA"/>
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        <property type="entry name" value="KilA/APSES_HTH"/>
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        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
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        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="654" mass="70745" checksum="C6D9B12EE8ACC4EA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066698.1">
        <property type="nucleotide sequence ID" value="XM_018218691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWJ1"/>
    <dbReference type="GeneID" id="28828417"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721990"/>
    <dbReference type="InParanoid" id="A0A194WWJ1"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267536" evidence="2">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="283" mass="29406" checksum="47B4D1519BFD3380" modified="2016-10-05" version="1">MKLSTSILSSVLFASAAVAAPSTLAERVQARKERRANPGSSHLPIPAPDSAGFATEPGNATLYYTNWSGGIIQSPPSGTTFFAIDGSFVVPEPAPPVSGAGTWYGTAWVGIYDNNAILQSGVDWGVTVSSSGAYSYQYNAWWEWYPNGWTDYNLVVNAGDQISVLCDAGSTSSANCLTVNQNTGDQVSQTLTAPSSSSTLQATSAAWIVEDFSSGGLVPFANFGTVTFTDCTAVAGVNFANGQNLYPNSGTATPADIVASSGSVITAVTFPEDTSNIVEVTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWV6</accession>
    <name>A0A194WWV6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_738248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066816.1">
        <property type="nucleotide sequence ID" value="XM_018220351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWV6"/>
    <dbReference type="GeneID" id="28830077"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738248"/>
    <dbReference type="InParanoid" id="A0A194WWV6"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="130"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="593" mass="67954" checksum="540DC326A6272083" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXU4</accession>
    <name>A0A194WXU4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_209156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066859.1">
        <property type="nucleotide sequence ID" value="XM_018205849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXU4"/>
    <dbReference type="GeneID" id="28815575"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209156"/>
    <dbReference type="InParanoid" id="A0A194WXU4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="232" mass="26099" checksum="C0159D8BAE0FB1BB" modified="2016-10-05" version="1">MLSLAYSGSFVCSRLLNHPPSFKFHSHGRSLLRSISLSTTRREYHRLLQLSRASFQASLARPSSVFRPITPLRRSNAFSTTSRRAEEGNKEDYKRVASSANSGSDNIIPFVGLLLLILGGVAGYAMGSNGTGSPAAPPSQNMTQRPMLKCWKEHCRQHQQAERHRQFLALYKSYPYTELDVQVATVMEPVLMNEMRSKVQETSVRIRETLEAARRRNEAPVEMSKSQPKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYK7</accession>
    <name>A0A194WYK7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_192465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067124.1">
        <property type="nucleotide sequence ID" value="XM_018205714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYK7"/>
    <dbReference type="GeneID" id="28815440"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_192465"/>
    <dbReference type="InParanoid" id="A0A194WYK7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="67" mass="7869" checksum="EC988A17E122151D" modified="2016-10-05" version="1">MNAFRLTQKRSRLHSVTVTPFTRSKSRTRLKNCNAKRHLFSLSPPAPPHNSFSGHQLRKRQRPINLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ68</accession>
    <name>A0A194WZ68_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_721299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067603.1">
        <property type="nucleotide sequence ID" value="XM_018218629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ68"/>
    <dbReference type="GeneID" id="28828355"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721299"/>
    <dbReference type="InParanoid" id="A0A194WZ68"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF56">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="369" mass="41808" checksum="96D00148ED41978D" modified="2016-10-05" version="1">MSESSESTVTSETSTLIYGQECFDTYQLKVIQLCNSLNLGAPSSITRMQGGCFNRVIGLSFSSKSVPSEYILHIPREPLEARERQSIKDQVAILLHLTAYLPVANVLAYDYTTENAILSQYVIQSRIPGSCVEAIYEGLDIEEKIEIAEQVAELIVKIESIELSAFGRLVQESPMPDSAHDLSQILNRNIGVQGYRQDLTKDMPTTSLKTLPELLRAMFKSHGVGDAGDEELVGYWDRLHLMLSEMESNGLLSNETITPRLTHWDLSSQNILVDKTDGVWKVTGVVDWDDAISVPEIIGRKPPVWLWAPEVRVEDVDVTDVGELNDGQQTIKERVEEVFCRQLPRWRDDAHLRGKWLRRIWAFARHEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZF9</accession>
    <name>A0A194WZF9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_197985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067347.1">
        <property type="nucleotide sequence ID" value="XM_018205762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZF9"/>
    <dbReference type="GeneID" id="28815488"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_197985"/>
    <dbReference type="InParanoid" id="A0A194WZF9"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56402" checksum="30BC9E8549FA6557" modified="2016-10-05" version="1">MSQSSDTSEPSKQFSCTVCGKRFNNKRSQIRHSSYCRKRARNPPKSRKRSCTPCTKAKCHCDGSFPSCSRCVKRNVTCIYQHSTPHANQLEQQSRAEVLSSDRDMTLVCHSTQDYRETAPTRDFDATDENLFQTETLFDEISSTAIVEEALENYGSTALFPHGLANLVSSAFLDPRYGMDFSNLEACYNLALSPALRAPRAFKPKMVKHRQLSLNRKYVICTLRSYPQMLLPGKGPPPFLHPHCMEQEYDQSESAQTSLIDPLARCSGIVAMWSVKNKDNSSFIWRSIRMEQERLSEECHTYDTRTAVAALQAVSVYFIFRVSEQDEDVTDFDIPLIQTMLNIAIRFKECSTRCFDPSASSALTWELWILIESLQRTIFVTFIVDILFDISAGTISDSNACIKADHLLQMRLPCSKSLWKTKTKSEWEKEYATQTNFQLENNYRHPRFIDLIRHDANANSFGSSLDRWMSEVDDFGMLVINAASLVDEFDFGAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZJ9</accession>
    <name>A0A194WZJ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_687918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067387.1">
        <property type="nucleotide sequence ID" value="XM_018215607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZJ9"/>
    <dbReference type="GeneID" id="28825333"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687918"/>
    <dbReference type="InParanoid" id="A0A194WZJ9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="55" mass="6758" checksum="F557518D975CB180" modified="2016-10-05" version="1">MLGVFLDLRSCYLPWSTSFLRNLPRGLLSHFRFALAFLRDLRFWLRHIFQSWGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZS2</accession>
    <name>A0A194WZS2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_721451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067801.1">
        <property type="nucleotide sequence ID" value="XM_018218653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZS2"/>
    <dbReference type="FunCoup" id="A0A194WZS2">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WZS2"/>
    <dbReference type="GeneID" id="28828379"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721451"/>
    <dbReference type="InParanoid" id="A0A194WZS2"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="490" mass="52799" checksum="4991DFB59DB9D311" modified="2016-10-05" version="1">MSLRIPAKRVVATLKASHASSSANAIFKRNASQATAAATNLPQETRNEIYRNATLSNPDPPADSATAALVNEQAPYMLKTYARPPPMFVKGEGCYLWDVENRKYLDFTAGIAVNALGHCDPEMARIIAQQAKTLIHTSNLYHNPWIGALSELLVKKTREAGGMHDAQSVFICNSGTEANEAAIKFARKSGKVVDPSGEKYEVVSFNNSFHGRTMGALSATPNPKYQKPFAPMLPGFKYGTYNDIDGINDLVTEKTCGVIVEPIQGEGGVNVGTEEFLVALAKRCREVGAVLIYDEIQCGLSRTGTFWAHASLPKSAHPDIITTAKALGNGFPIGATIVNTSVAEKIVVGDHGTTFGGNPLGGRLAHYIVSRLSDPNLQESVVAKSKIMVKHLEQLQKKYPELVKEIRGKGLILGLQLTQDPTPIVTAARERGLLIITAGKNTLRFVPSLSIKEEEIEEAFTILDEAMRVATSPGEHPAGKQVSGEVDSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZX5</accession>
    <name>A0A194WZX5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_753683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067522.1">
        <property type="nucleotide sequence ID" value="XM_018221285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZX5"/>
    <dbReference type="STRING" id="149040.A0A194WZX5"/>
    <dbReference type="GeneID" id="28831011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753683"/>
    <dbReference type="InParanoid" id="A0A194WZX5"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="201" mass="22245" checksum="AA5E658F458D1D28" modified="2016-10-05" version="1">MEGMEWALHNLGTLYADQGKLAEAEKMYTRALQGSEEALGPDHTSTLSTVNNLGTLYKNQGKLAEAEKMYTRALQGKEEALGPEHTSTLSTVNNLGALYADQGKLAEAEKMYTRALQGYQQALGPELLPSYLPALNTMFAFGDLFSQTSRKDLAKEMYSRALARYTAVQPSSKWSKIGFTEPVAQDSRRLKRKHSANWESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X042</accession>
    <name>A0A194X042_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_160102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067921.1">
        <property type="nucleotide sequence ID" value="XM_018205492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X042"/>
    <dbReference type="GeneID" id="28815218"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_160102"/>
    <dbReference type="InParanoid" id="A0A194X042"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF4">
        <property type="entry name" value="CELL WALL GALACTOMANNOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267661" evidence="1">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="175" mass="18345" checksum="28C7E65A80C67A3D" modified="2016-10-05" version="1">MRFALLPLGVSFLITQVLADGASILTAMTTITNATLALNTTLNSFPSNPELAIGDIAPLLVDSVNLLDDINNGVTVATQSANLTLPETIEVAQATLNLSTAVSTTLSNLMRTKANFDKLKVITPVVLVNLKLENAASERFGAAVVAKVPPAFQAQALSLLAPIEASFNTTIAYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0C2</accession>
    <name>A0A194X0C2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_144664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068000.1">
        <property type="nucleotide sequence ID" value="XM_018205343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0C2"/>
    <dbReference type="STRING" id="149040.A0A194X0C2"/>
    <dbReference type="GeneID" id="28815069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_144664"/>
    <dbReference type="InParanoid" id="A0A194X0C2"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="396" mass="44877" checksum="D886F9FCAC051D61" modified="2016-10-05" version="1">MFRRLSSGLPKNPIFPHDLKGLGYFVNKNDEIRSIEDPKAYFKFFITRNDRHNCVQREAMNAIRNLIADRLQKLGLEKIRLPLGAEANEPNLPIFISSNIQDKKRVIIVFNESSQDLGVFAHRIIGGKGGVSEGSALNLVKYIQSQATSPDNNDPPGIILANMGQLRWWRRGKKAVTLTSWNALPQDSAVEQAFRFDEVKNTIPFNRTTYEHVEYVFNEVVEKLVAADAQLNVIGVSEGAVQVETFLEKPKNFNKWGKRVSALAVIATYFLGHEIQNQEFAKWFINHGRGYLVSNEPGGVFLADYNGRKRIPAYGCPVFSLGEPYYAETLLPKGYKTVVDWFQEVASDRDYANPKFDRYDFGGSDNEEEAGEDDAAWNTQEKLGTIKDEERIVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0E6</accession>
    <name>A0A194X0E6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mmge/prpd family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_590793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068026.1">
        <property type="nucleotide sequence ID" value="XM_018209615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0E6"/>
    <dbReference type="GeneID" id="28819341"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590793"/>
    <dbReference type="InParanoid" id="A0A194X0E6"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="286"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="465" mass="49285" checksum="2893BB2BB6AC4EFF" modified="2016-10-05" version="1">MATHHLASWACSLKYSDMPQNVIQAAVRSFYNWAGCAIGGSKHPATTIAHNSLSPFFGPPTASLLGHQGKTKIDAQHAALLNGIASHVHDYDDTHLDTIIHPTGPVASALLAVAEWKGGFSGKDFLLALIVGIEAECKVGLAVWPEHYDVGWHITSTTGSIGAAVAVSKLLGLSISQTTNAIGVAATQVVGLREMFGSHTKSFHPGRAAQSGLMAAVLAEGGYTSSEQALEAKRGWANVVGVTKPGIAADLDKWLGMNAEASEHGVGLFSAGVGRWEILRNSFKPFPCGIVIHPIIDASTQIHGDMKTQGLDAQNIKSVHAKVHPLVLELTGKRKPKDGLEGKFSVFHGAAIGLIYGKGTPSEYEDHVVQDAKVIAIRDKVNAESDKSLGADETIVVATMSDGKILERHVKHAVGSLEVPMDDGMLQRKFVDQCAAVLGDRVQAASEICWDIEYAKDVADVAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0L5</accession>
    <name>A0A194X0L5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_158151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067767.1">
        <property type="nucleotide sequence ID" value="XM_018205471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0L5"/>
    <dbReference type="GeneID" id="28815197"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_158151"/>
    <dbReference type="InParanoid" id="A0A194X0L5"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="42193" checksum="022D98AF686A6CBD" modified="2016-10-05" version="1">MEFIPEKRRVVITDENLGPIVSIVSILLLISVVLIVLSRLCTRYFLRRQLSLEDGLVFAAAILSTGELVTILGLDSNGLGSPIQTLSKEQVLRFQKYSYSTDVLYVLNIGLTEISILRLIYSLTPVKNQKIVALMAIGFTTLWTISSLFALLFQCHLPHVWQFIDNRCINKVSFWISYTVVHIVTELAVIFLSVVLVWDSKLLRGVKLLVVFPFTLRILVLVPAIAQIAYFAPAIKSRNPTFELWTSVLCAQITQTISITTACFIQLRPFITSLHSGLLHNNDARRRIRQDSRSGSGYLSLGGKGRNWSDTGRSGSDAPALAPESRNVFVGGRDPWGQYGKDLNENSDGSPTSAPAGRISQVIRQTTSIAVEFSDRHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3N8</accession>
    <name>A0A194X3N8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_649372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069168.1">
        <property type="nucleotide sequence ID" value="XM_018212057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3N8"/>
    <dbReference type="FunCoup" id="A0A194X3N8">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3N8"/>
    <dbReference type="GeneID" id="28821783"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649372"/>
    <dbReference type="InParanoid" id="A0A194X3N8"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="352"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1262" mass="142249" checksum="703D8809F7F50E35" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X443</accession>
    <name>A0A194X443_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_620191</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069310.1">
        <property type="nucleotide sequence ID" value="XM_018210903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X443"/>
    <dbReference type="STRING" id="149040.A0A194X443"/>
    <dbReference type="GeneID" id="28820629"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_620191"/>
    <dbReference type="InParanoid" id="A0A194X443"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="277"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="46470" checksum="1F4AF8380DD87CAB" modified="2016-10-05" version="1">MYKPVLRTSARQLSSAARPVAVRSYAAHATPQPFNWQDPLDAQNLLTEEEIAISETAESYCQERMLLRVLQAYRDENYDKKILEEMGELGLLGATIKGYDCAGVSNVASGLITKAVERVDSGYRSGMSVQSSLVMGGIDEFGTQEQKEKFLPKMAKGKLLGAFGLTEPNHGSDPGSMETTAKPHPTKKGYLSISGAKTWITNSPIADVLLVWAKLAETGKIRGFLIERSECPPGTLETPPIKDKNGLRASLTGMIQLDECPVPEANMFPDVEGLKGPFTCLNSARFGIAWGTMGALEDCIDRARTYALERKQFKGNPIAKYQLVQKKLADATTDAAYGTLAAIQVGRLKDEGKAAPEMISMIKRQNCDRALVNARILQEVFGGNAVSDEYGIGRHVANLFVTQTYEGQSDIHSLILGRAITGIQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X460</accession>
    <name>A0A194X460_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_126569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069323.1">
        <property type="nucleotide sequence ID" value="XM_018205200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X460"/>
    <dbReference type="GeneID" id="28814926"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_126569"/>
    <dbReference type="InParanoid" id="A0A194X460"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="219" mass="24597" checksum="0AF17166A09048E1" modified="2016-10-05" version="1">MEQKVEPKKGDSKKGAIEGQVVPQHPGSTKVVEEMSSSHDQLSFRPSSLENHSLDLHNDHSAASEHRICRNDEIDHFKGSKEELNDEEENNGLLGGVDDIENSTTRIEDSGPRTSDVPEPYSWESWLGSTQAMDEGTAIFEYSDSGPFKVLNVRPPEDYSNDPNIVGTLCVMCRWMFDHLRLIIDYFTYPLYRLMFTLSIGTLACGLSLQQTAVVECVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4P6</accession>
    <name>A0A194X4P6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-N-arabinofuranosidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_735280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069500.1">
        <property type="nucleotide sequence ID" value="XM_018219993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4P6"/>
    <dbReference type="GeneID" id="28829719"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735280"/>
    <dbReference type="InParanoid" id="A0A194X4P6"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267896" evidence="6">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="385" mass="42904" checksum="826457659DEC1A2D" modified="2016-10-05" version="1">MKFLSLLVIGGAVASAQNINNGGSSNFTDVGTNFTTNATYSNPIMTLNVGDPWMTRYQSNGEGWYLFTYSTNDNVTLKRSQSLTDDWDHADERVVFNPDPNSGLPYATDLWAPEIHNISGTWYIIFSATPDFDAPPPLVDAMCPFECPAVNHRMFVLQGDGPDPWTCNFTMKGMLDTFDQFAIDGTFFQYNDQLYHIYSCWENTYSAWPANLCITQLSDPWTVASNLTDRRMISVPDQPWEQVPYGRAGRLATNEGPEQLTNPTTGQNFVVYSAARVNTPFYCLGMLELVGNDPMQYQSWKKHTDGCVFHQNTQAGVYGTGHASYTTSPDGSEDYVVYHALTTPNPPSNIYRTVRTQKFTWNSDGTPNFPLAANGPFPVPAGQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4P9</accession>
    <name>A0A194X4P9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_648327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
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        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ15169.1"/>
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    </evidence>
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</entry>
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    <accession>A0A194X5G3</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
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            <end position="30"/>
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            <dbReference type="EMBL" id="KUJ15411.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
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    </reference>
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        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ15714.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6M3</accession>
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    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070186.1">
        <property type="nucleotide sequence ID" value="XM_018218500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6M3"/>
    <dbReference type="STRING" id="149040.A0A194X6M3"/>
    <dbReference type="GeneID" id="28828226"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719534"/>
    <dbReference type="InParanoid" id="A0A194X6M3"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="26222" checksum="B27413CCBB9C1FE9" modified="2016-10-05" version="1">MSNLKVAVLMNGFTSPNTPMIRDSFISALEAAASSIDSFETPTIDFYDPIVAQIHPDLSAYDLIVLSGGTVDPMGSDPWVLKLQTYLNTTVAEHPKQKIVGICWGHQTTSVSFGGKVGNMDGPEIGVHQITLTPEGKKMFPFAQDGKLNIHEFHRREIKSPAKGFVPLAEGSQSFINEANTIITFQGHPELNAALAKNFVETTPAYMGLDDEKKAGLVASAGLEHDGVKIWERILRWVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6Z8</accession>
    <name>A0A194X6Z8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_686293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069932.1">
        <property type="nucleotide sequence ID" value="XM_018215253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6Z8"/>
    <dbReference type="GeneID" id="28824979"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686293"/>
    <dbReference type="InParanoid" id="A0A194X6Z8"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="555"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ15577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="635" mass="72531" checksum="FD6BC613CCD47E75" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7C3</accession>
    <name>A0A194X7C3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_102817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070430.1">
        <property type="nucleotide sequence ID" value="XM_018205021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7C3"/>
    <dbReference type="ESTHER" id="9helo-a0a194x7c3">
        <property type="family name" value="Zearalenone-hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="28814747"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_102817"/>
    <dbReference type="InParanoid" id="A0A194X7C3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="29561" checksum="0FC6365E95CDB0CB" modified="2016-10-05" version="1">MAHIFQVETDDGISWYVEQSGTGPHILLVPSGEGDCSVYAKAASHLSSHFTVTTFDLPCFSRTIAPHSAVAAETLTPYKIADQIVSLMDKLSISTASVFGSSSGGNIGFAMLQKYDQRVEKLLVHEVPLHVLGDLKSWVDQPTSEDPKTVATCQHIFAHAMNEDLAAWEGLGAEYHKRLHTNYVTWYRNYSPVVEKLLWDKEELKKKKERIFWSVGGLMPLSWFWENVVLATETGVKLEVLNSKHFPQVSIPGELAEYIKKCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7G9</accession>
    <name>A0A194X7G9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enoyl-CoA hydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_685165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070473.1">
        <property type="nucleotide sequence ID" value="XM_018215028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7G9"/>
    <dbReference type="STRING" id="149040.A0A194X7G9"/>
    <dbReference type="GeneID" id="28824754"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685165"/>
    <dbReference type="InParanoid" id="A0A194X7G9"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF68">
        <property type="entry name" value="CARNITINYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="284" mass="30429" checksum="A8C575B17AC1CFD1" modified="2016-10-05" version="1">MPHNFQFDPPKSSSLSLSYPRPGIMVVTISRPQAMNSLPYPAHYEADAIFTWYDNEPSLRVAIITGSGPKAFCAGQDLIELNSAKSAPSFSADPTGRGGRGHPPSGFAGISRRKGKKPIIAAVNGFALGGGFEICLNCDLIVASPTATFGLPEAQVGLYAAAGGLPRLVRNVGLPLASEIALTNRKLTAEEALKFNLINKISETRESVLDEAIEMAAKICTLSPDAVVVTRAGLREAWEVASVEEARRLVADRYEKSLFSGENMRIGLKAFATKTKPEWVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Y1</accession>
    <name>A0A194X7Y1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_647967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070272.1">
        <property type="nucleotide sequence ID" value="XM_018211982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Y1"/>
    <dbReference type="GeneID" id="28821708"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647967"/>
    <dbReference type="InParanoid" id="A0A194X7Y1"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42391" checksum="560D8930AFD16086" modified="2016-10-05" version="1">MKAYIAVPVTLAMVYRAWSHQSLTPAGIVAAALTATAHAVHPWSLPFALLIVFFLAGTRVTKVKHDVKAKLTVQASGSAGGEGARTHIQGQYSLSSYLRILANSAVASVLTLLHAYQLRQREQNPSACYSWPGDILVVGIVANYAAVAADTFSSELGILSKSKPRLITSPTLREVPPGTNGGVTAYGLAAGLLGSLVIVTTSVLLIPFCSPKSGVLGFGGTAGWSFLDRQRFAFAMTIWGALGSVLDSFLGGWLQQSVVDTRSGRVVEGEGGKRVLVSKGGPNSMHYKKRAELKAKLLHGDGKDALEIQPASDESSISAQIEEALNHKMGGSDKYDPKKKFRKPSFGDEKPSRVVESGTLALLDNNEVNFLMALTMSLGAMGVASWFWDVPFRSIFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8B7</accession>
    <name>A0A194X8B7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070773.1">
        <property type="nucleotide sequence ID" value="XM_018219915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8B7"/>
    <dbReference type="STRING" id="149040.A0A194X8B7"/>
    <dbReference type="GeneID" id="28829641"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734515"/>
    <dbReference type="InParanoid" id="A0A194X8B7"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="288" mass="30364" checksum="65FB690A02CD8964" modified="2016-10-05" version="1">MAQSTTGGDPASVPFDSSSSSSQPHSGLPVEMSELDASKRTGAGSQALLNDVSIPTSSPLDSSFPTSSSMSNPATENARPDEQSNAAISTSQASANPLSSSTNDASTNTTAVAASEPASSTIPSITRLDSVAIGPSTEHTPPPAISEAGPVLVITLLLTSGARHPYKIDEKYLTKRNVNVPGVTESGRKDPFSISVYTLKELILREWREEWEAQPSSPSSIRLIYFGRLLDDKTPLKECKFNAESANVVHMTVRPQDIVDEEDATKGKSAGRDRGDGESTAGCRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X901</accession>
    <name>A0A194X901_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_647372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071003.1">
        <property type="nucleotide sequence ID" value="XM_018211954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X901"/>
    <dbReference type="STRING" id="149040.A0A194X901"/>
    <dbReference type="GeneID" id="28821680"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647372"/>
    <dbReference type="InParanoid" id="A0A194X901"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="38712" checksum="638758B25A921F5F" modified="2016-10-05" version="1">MPKAITMQHIEGGKPGKVYYPLSLVDVPTPNPGPNDLVVEMHAAALNHRDFFLRQHLYPAPSFDVPLLADGYGIVTAVGSSALKSWLGKKVILTPGRGWKDDPAGPESPTGYAILGGTKTFQLGTLQEVLCVHEDEVDEAPNHMSPAEAAALPLTGLTGWRALMTKSENAQKGRNVLITGIGGGVALNVLQFAVALGMNAYVTSGSQEKLDKAKSMGAKGGVSYKDEGWEKELKNQLPKDRPRLDTIIDGAGGNIISKAVRLLKPGGIIVQYGMTVAPKMDWLMSANLLNLELRGSTMGSRKEFRDMVAFVNEKNIKPIVSRTVKGIDNLKDIDGLFEDMRHGSQFGKLVIELGGTTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X965</accession>
    <name>A0A194X965_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3">2.1.1.233</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein phosphatase methyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_781998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071063.1">
        <property type="nucleotide sequence ID" value="XM_018222534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X965"/>
    <dbReference type="FunCoup" id="A0A194X965">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X965"/>
    <dbReference type="GeneID" id="28832260"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781998"/>
    <dbReference type="InParanoid" id="A0A194X965"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="50697" checksum="562F438C580FA19C" modified="2016-10-05" version="1">MSYGSVATAVTARVRATFEMLAPDSLMIYQAAGKLAITFAEDRSGPESSTDILAASLQRGCSAVPNTRIHLEFQDMSAQQIPNLLTLRGGPRSRGGRARGRGRGGPHSGNPELQAQLQKDRDVQSTDTDAAVSRLSAVDLGYLHDPFASLFVNGPGTRRLPIINRGTYTRTTALDILINAFLSHPDSTPTVPQTKQIISLGAGTDTRYFKLRAQNKHRHIIYHEFDFVSVSITKERIMKNNGLLWEDEGEAFFKALETVPGFGEHESEWGLERSKDGITETTYCFHPLDLRHLLKTSKPVRGLRTDVPTLIVSECCLCYLEVETSREVVKWFTSRIPSIGLILYEPIGLDDSFGQMMVSNLAARNITMPSLEAYKTLPDQKARLAQLGFTSEGGGQEAETVEQIWEKWISIPEKERVDALEGLDEVEEWQMLARHYAIAWGWRGTTGWEGLATLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAR8</accession>
    <name>A0A194XAR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_733859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071212.1">
        <property type="nucleotide sequence ID" value="XM_018219848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAR8"/>
    <dbReference type="GeneID" id="28829574"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733859"/>
    <dbReference type="InParanoid" id="A0A194XAR8"/>
    <dbReference type="OrthoDB" id="10358118at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="20932" checksum="70C1F09E4D550FDC" modified="2016-10-05" version="1">MFNVSRREYEDGICLIAALAKVSYGFTPPAGLPNGVYVYDPADGTHTSIDGTLVSRDLDYLSTGTSFTPRALNSAKFSPRWTGITCGDTVLASLDYASALVQLEGQCDGVTKLPKKNYYSVYGDAMAFICVYKKNTICNVGTATSGGTDMLFALAQLDNKCSATLQSEKSPNHVDGYNRVSNSIVFGFTTSTSSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCB3</accession>
    <name>A0A194XCB3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_669100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072168.1">
        <property type="nucleotide sequence ID" value="XM_018213066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCB3"/>
    <dbReference type="GeneID" id="28822792"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669100"/>
    <dbReference type="InParanoid" id="A0A194XCB3"/>
    <dbReference type="OrthoDB" id="3557310at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268132" evidence="2">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="38930" checksum="99396EB7DB8653EF" modified="2016-10-05" version="1">MTLYFLSLLHYPLAQCFFLLSQFLKPTYRVIPRDRMNPPPPNDRFAKAKNIARTSLKRFGPLLLTGLAAVVEHHWLKRDDDPPPPEQPQCDDRDRSSIKELKHEVKKLRKKLKGKRKYRDDSSSSSDSSSTVAYHQRVVESPMRGRRRPLGEEQTRERDEYYRGFETRGNPPPPVPDPPQQYQRYQTFQPPQLPHEMTMLGQASSSRDIQRPPPRQVSHHRPRPRRRHHSLPSIIDAEFSPTTIHAGKVAAVAGFIEALHVGDFRGDWIGRKGARVGTTMAASFGASVARDKDPRDLRRREIVMDVGKGLAVSRLVHGRVERVEDGYRRRGRRWSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEQ1</accession>
    <name>A0A194XEQ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_581992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="579" mass="63361" checksum="8A4A1EDA68DF4799" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFG8</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    <sequence length="358" mass="39976" checksum="D6858058001BF29F" modified="2016-10-05" version="1">MHRTYSMRQSRAPTASQLQNPPPPSSSTKSGRLFGKGGIGHALRRQTAGQFGPDLAKKLSQLVKMEKNVMRSMELVGRERMEVAQQLSIWGEACDDDVSDVTDKLGVLIYEIGELEDQYIDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPKIVVLEQELVRAEAESLVAEAQLSNITREKLKAAYTYQFDALREHCEKLAIIAGYGKHLLELIDDTPVTPGETRAAYDGYEASKAIIQDCEDALTNWVTANAAVSSKLSTRARTLSQRRRNNIQRNPEGHDLTGQDAPMNDRESGLWVPASAHKGGEDYEDEEEEEEEEVAAPSIQDSALNGEARGRQETVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFW7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_774610</name>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018221971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFW7"/>
    <dbReference type="GeneID" id="28831697"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_774610"/>
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    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7791"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="168"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="447"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="582" mass="66247" checksum="E8A46944EEFD1474" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFY4</accession>
    <name>A0A194XFY4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_562687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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</entry>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
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        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19972.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="94" mass="11116" checksum="183F229BC5585E76" modified="2016-10-05" version="1">MSGRISDRYASFFKCDVMDYYCRERNFLYSFFFSFSIMACISANFQICFADMFRGITCFEMCTGNIHVSLSLRDLLKQRHGISLRSHEFGLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKU5</accession>
    <name>A0A194XKU5_MOLSC</name>
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        </submittedName>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="28822631"/>
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        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="15713" checksum="0BF1C03EAA4D31A7" modified="2016-10-05" version="1">MSKASYIHFTAPESYQFIIPCIIESRLWRSDVFTLIDLYNSRHPKNTTGNGSALVSTQSPIAGVNHSPPHTPPQGPVAVPVPAWGRGGGAANPPSTGPWARSVVAPTGAPLPRGRERGNQSPQSGLGPGVGRGAGRGTGQSRGVWSGNGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL82</accession>
    <name>A0A194XL82_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_422252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075350.1">
        <property type="nucleotide sequence ID" value="XM_018207417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL82"/>
    <dbReference type="GeneID" id="28817143"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_422252"/>
    <dbReference type="InParanoid" id="A0A194XL82"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="89" mass="9813" checksum="36A0A7DA286A985F" modified="2016-10-05" version="1">MWNNHLLPSVLSRLLSFVPALYFEIPKASLILVIRKWKSKDPSTLAHYCVTTLLNALTITTGSLFTLHSSPDATIMGTNERGVAACKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLG8</accession>
    <name>A0A194XLG8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_577174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075378.1">
        <property type="nucleotide sequence ID" value="XM_018208875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLG8"/>
    <dbReference type="GeneID" id="28818601"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577174"/>
    <dbReference type="InParanoid" id="A0A194XLG8"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="129" mass="14102" checksum="7A5BB832186F6368" modified="2016-10-05" version="1">MATDIQEIRTTNAPAPLPVFSQAIKANGMVFVSGNIGFNVETWTLVEGGIQAQTDQTLKNIKAVLEEAGSSFEKILKLNVYIKDFGDFKAMNETYITHFPGRKPARTCVAVADLPFNAIVEMECTALCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLK0</accession>
    <name>A0A194XLK0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_715261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075314.1">
        <property type="nucleotide sequence ID" value="XM_018218191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLK0"/>
    <dbReference type="STRING" id="149040.A0A194XLK0"/>
    <dbReference type="GeneID" id="28827917"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715261"/>
    <dbReference type="InParanoid" id="A0A194XLK0"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="771"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="776"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="798"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="838" mass="90814" checksum="2029ECA83E5D7B89" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLZ2</accession>
    <name>A0A194XLZ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_715426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075511.1">
        <property type="nucleotide sequence ID" value="XM_018218204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLZ2"/>
    <dbReference type="STRING" id="149040.A0A194XLZ2"/>
    <dbReference type="GeneID" id="28827930"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715426"/>
    <dbReference type="InParanoid" id="A0A194XLZ2"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="265" mass="30248" checksum="597419936B29C1FC" modified="2016-10-05" version="1">MSARTTSDVARKATRAIGKSKPSPTALGPRRKRDYGRQIFVFNHLQKNMIVYSLTKALRNNAALNQIPFNGKKTVPAALRKDLWHPFAQITFPEGKGFVGLSAFQKLREYRKRHELEWGDEIFLDKEGKHVNKEIRGRQICDQKANSVADMAAVLGRLALKDKPTPEIVNGRKIWPPRIGLKREGQGVNVQVLWRDLTDAEFAETWAENVEHGVLPMHTNHRDPNRVWGYGRMTGRTKEVEEQEIIPEVVSEQVVTEKEPEKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNW1</accession>
    <name>A0A194XNW1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_729351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076206.1">
        <property type="nucleotide sequence ID" value="XM_018219373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNW1"/>
    <dbReference type="GeneID" id="28829099"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729351"/>
    <dbReference type="InParanoid" id="A0A194XNW1"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="152"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="429"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="658" mass="75274" checksum="4BC137007EC64649" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP32</accession>
    <name>A0A194XP32_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_638124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076360.1">
        <property type="nucleotide sequence ID" value="XM_018211559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP32"/>
    <dbReference type="FunCoup" id="A0A194XP32">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP32"/>
    <dbReference type="GeneID" id="28821285"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_638124"/>
    <dbReference type="InParanoid" id="A0A194XP32"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="48679" checksum="E9F17192C9320CA1" modified="2016-10-05" version="1">MSTSQKAVRPLARCLRSLQSQRQSANNFRTLSSSARCNVEAVVDSTPEKPIFDPETVTSIKGEKALMKSGILPIGSRRRRAAIKSSDNIPFEQLPYLCFQEARKVLQEDREEKLKLIATERLRISNMLARDPSTFKGGVLEKETKLSSMRRYLEWLKIQADINDPLIKKRFEDGEGDMNKPIYRYLADRKWREYQRKIIVQRIEQFGIVPDFLPHFEPTAEVQLAFKNRNVQPGEYIDSRVSEVAPRLKVQVFNKGERLVTVVVIDGDVPDAEKDRFGTRSHFIATDIPLSPTDTSIPLSKVTKEQLVQPWLPPFAQKGSPYHRLAVFVLEQQPGQPKVEAEKWAERDNFFLKSFIGKTRMTPIGFNMFRATWDDGTAGVMERASIEGADIEFKRKKVVALKPKQKARGWEARHASDKYKSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPR2</accession>
    <name>A0A194XPR2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076506.1">
        <property type="nucleotide sequence ID" value="XM_018214303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPR2"/>
    <dbReference type="GeneID" id="28824029"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681464"/>
    <dbReference type="InParanoid" id="A0A194XPR2"/>
    <dbReference type="OrthoDB" id="3565130at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="275" mass="30724" checksum="1E02E55293376C09" modified="2016-10-05" version="1">MVAKDRHANLPFGKKNPTTRASKKSLVIVPTDLSTGPPSTVGILPKVLSTTVNFQRTPGARADISISATEVTRNEMKVVIQTFDDGQVETARSYPYNSTMYDLADDVSNRMPYSAKVEYLKDRWVEMQVKIPEISSSVSESDSAVLEQLSSLGPDFFKLVSNLVVRLVLPALSNLAVMTPSNIVSTPGYALVERIVDEVEKFVALEKLHVVLELPHTFTRGLHELQMVYSLPFHYLSFTDWGLRYTVPSMTRSKVVSDDDLLQLRRLDQSLFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ00</accession>
    <name>A0A194XQ00_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_693741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076690.1">
        <property type="nucleotide sequence ID" value="XM_018216658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ00"/>
    <dbReference type="GeneID" id="28826384"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693741"/>
    <dbReference type="InParanoid" id="A0A194XQ00"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="59813" checksum="5A255677B7C413E4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQP7</accession>
    <name>A0A194XQP7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_575731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076734.1">
        <property type="nucleotide sequence ID" value="XM_018208804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQP7"/>
    <dbReference type="GeneID" id="28818530"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575731"/>
    <dbReference type="InParanoid" id="A0A194XQP7"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="673" mass="75101" checksum="B09EFD7AAE70E5F3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRA1</accession>
    <name>A0A194XRA1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_680836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077073.1">
        <property type="nucleotide sequence ID" value="XM_018214148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRA1"/>
    <dbReference type="FunCoup" id="A0A194XRA1">
        <property type="interactions" value="1506"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRA1"/>
    <dbReference type="GeneID" id="28823874"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680836"/>
    <dbReference type="InParanoid" id="A0A194XRA1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="24285" checksum="0D0CD8F8355D2CE5" modified="2016-10-05" version="1">MAEAAQVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFSTNLGNIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPTLEFVAAPALAPPTASVDQALLEQYQKEMQDAAQMPLPDEDDNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRC8</accession>
    <name>A0A194XRC8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_714112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076637.1">
        <property type="nucleotide sequence ID" value="XM_018218104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRC8"/>
    <dbReference type="FunCoup" id="A0A194XRC8">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRC8"/>
    <dbReference type="GeneID" id="28827830"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714112"/>
    <dbReference type="InParanoid" id="A0A194XRC8"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="67"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="378" mass="42533" checksum="087F0611FE8B93F3" modified="2016-10-05" version="1">MAPYQAPSQPSQEQLERRRLVGVNAETVTDVSSVDFPGHYPGEDHSWDAAKFRDNFQVKFYQNDPLESSFSLIGLDASVANAFRRILLSEIWTLAIEYVFVYNNTSIIQDEVLAQRLGLIPFKGNKKGLRDFLRPYHKPEEGSGEKIEGYDYNTIILALKIECTRNDQAARGETNPHKAYHNAHVYAKDIVFKPYGEQTKYFSGEGAIQPTNPDILIAKMRPGQCIDVEMHAVMGIGSDHAKFSPVATASYRLLPSIQILKPIIGKDAKKFAACFPQGVIDLEPVTKKDASKKGSGFEGHEGEMKAVVKDAMKDTVSRECLRHKEFEGKVKLGRVRDHFIFSIESLGQFDSEELFIESIQVLRKKCLALKENLSNMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRD3</accession>
    <name>A0A194XRD3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_305785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076969.1">
        <property type="nucleotide sequence ID" value="XM_018206597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRD3"/>
    <dbReference type="FunCoup" id="A0A194XRD3">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRD3"/>
    <dbReference type="GeneID" id="28816323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_305785"/>
    <dbReference type="InParanoid" id="A0A194XRD3"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="126"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="52299" checksum="A24B53BB223EF353" modified="2016-10-05" version="1">MYMNTALVDPDIAADLRLGHHLPLVKKTLQSLKVVEYLGPSAEESTFSSKNVRIEVYVYGLYGNARSLEEDRHFPQAELTPMPHIRFEGIWDELVFTDNIKEDLLWMMINILRFSLRSSDNSRGEVNPLILLHGPPGTGKTSLCQGLAQKIAIRLRSQYDHTTLVQINTATLLSKYYSESAKQVDEIFTKIACLCQEEPNTFTCVLIDEIESIASSREFSTTGDESHDSLRATNALLTGLDKTNHYPNVIFLCTTNMFTALDDAFLDRCGLKREVAIPSLPSQYQIIRKRLQKLIDRGVIQTDESLLSHEDARLCAELDSRNTPARLLAIAQLINSCPGMSGRSLTQLPERAVLQHLREDECDMDMALTFIERVLKLPQPKAQETESYVKVEQTEKKLSSIPDPQAEKHERKNDIQVEQHGTEIEIRGMKRTLRMLFEDDLDIEVLQRCIAEARKRPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRS2</accession>
    <name>A0A194XRS2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BEM46 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_680974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077248.1">
        <property type="nucleotide sequence ID" value="XM_018214180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRS2"/>
    <dbReference type="FunCoup" id="A0A194XRS2">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="ESTHER" id="9helo-a0a194xrs2">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="GeneID" id="28823906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680974"/>
    <dbReference type="InParanoid" id="A0A194XRS2"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="105"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="34719" checksum="449FF5363ADB776A" modified="2016-10-05" version="1">MSSSQDNSASYLQQMTSVLGAVANYMRLPVIISSGIAALLSSLLYFKQKALIYPSHVPNQSRTTVPRPSEFGITDFEELMIPTPDGEKLSAFYIRPPNKRAQKNVTVLMFHGNAGNIGHRVPIARMFVQRMGCSVLMLEYRGYGLSTGSPDETGLMIDAQTGFDYLRKRAETRDNDIVIFGQSLGGAVSIQLVAKNQNDKRMVGLVLENTFLSMRKLIPSIIPPARYLTLLCHQVWASDTFLPSITEVPILFLSGLQDEIVPPSHMRRLYEICQSPTKIWKPLPGGDHNSSVIEEGYFESIADFVANLDTKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS97</accession>
    <name>A0A194XS97_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_164657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077371.1">
        <property type="nucleotide sequence ID" value="XM_018205519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS97"/>
    <dbReference type="STRING" id="149040.A0A194XS97"/>
    <dbReference type="GeneID" id="28815245"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_164657"/>
    <dbReference type="InParanoid" id="A0A194XS97"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="640" mass="70951" checksum="B7CD1570BA1928CB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSF8</accession>
    <name>A0A194XSF8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_693293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077329.1">
        <property type="nucleotide sequence ID" value="XM_018216623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSF8"/>
    <dbReference type="GeneID" id="28826349"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693293"/>
    <dbReference type="InParanoid" id="A0A194XSF8"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Myb_dom"/>
    </dbReference>
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        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF238">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="19850" checksum="A9F0A366DD1BEA69" modified="2016-10-05" version="1">MSKRGAERTEPESSTATSPAQSHSATADPSVKVETSSPPGSRNKRRASGTGPSVPTMSGSSSATGAAGAGEESSMASPTMGPPAKKSRTNTPWTPAEEQRLKTMRDAGNSWADIAKTFPSRTEGSVKKHWYKDMHYAEFAEDESQALLNAIKEYETNKWKEIGKKVGKPAKACEQYAKEHFAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTA9</accession>
    <name>A0A194XTA9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_680136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077736.1">
        <property type="nucleotide sequence ID" value="XM_018214019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTA9"/>
    <dbReference type="STRING" id="149040.A0A194XTA9"/>
    <dbReference type="GeneID" id="28823745"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680136"/>
    <dbReference type="InParanoid" id="A0A194XTA9"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="38436" checksum="8F383BDA23E0732B" modified="2016-10-05" version="1">MDANGTPNAPNTRAQPSIRSFFQPRPQPSYTAPPSLPVSEPATTLSGSVPSNNSSDSNSKSARAPKSTLPRQASISLISQSHVQPLRRINSLLLPIHYPDSFYHKILSPDPPISFSRVISWTDTDTKVIGGIVCRLDPALASDSTPESPKYVPNSYDIYIQSLALLSPYRGKGLVTAVLNVIIAAATAQSEIRIESLYAHVWTENEEGLEWYSARGFKPEGAVISGYYRRLKPDTAYIFRRRLTPTDHLQSASLPTLQHSQSAPTPTVSSSNSPAPPSDALRPGPPSSARSFQEQGPEREWNDLPEDVLSAALLKPASQLASKEGSTTSSRSSSQSRTVKEKKKRVYPAAAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTZ9</accession>
    <name>A0A194XTZ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sphingosine-1-phosphate phosphohydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_635391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077537.1">
        <property type="nucleotide sequence ID" value="XM_018211442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTZ9"/>
    <dbReference type="FunCoup" id="A0A194XTZ9">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XTZ9"/>
    <dbReference type="GeneID" id="28821168"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_635391"/>
    <dbReference type="InParanoid" id="A0A194XTZ9"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="112"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="591" mass="64982" checksum="B9A5C1CDE78E5D03" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUF6</accession>
    <name>A0A194XUF6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_571658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078305.1">
        <property type="nucleotide sequence ID" value="XM_018208604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUF6"/>
    <dbReference type="STRING" id="149040.A0A194XUF6"/>
    <dbReference type="GeneID" id="28818330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571658"/>
    <dbReference type="InParanoid" id="A0A194XUF6"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53986" checksum="B6B1A5ADCF05186A" modified="2016-10-05" version="1">MLGGRLPKELRRILPIYVACVLFVLFFARANPYKSPLEASEVIKRVLAAYQTPLQSTRSAFPRKIWQTWKIDPLDFETRDSERARSWTSMNPGYRYEVLTDSNDLHYVETHFGPGPGGLNRPDIVNMYRSLNATIIKADLLRYLMMYIEGGVYADIDVEALKPVDQFIPSHIDEDDVDLVISVEIDEPTYANHTILGPKSQSFCQWTFMSKPRAPVLLRLVDHILGWLEGVAAKQQKPIGEIVLNFDEVITGTGPSAFTGLILAEMARQTGNIVTWDSFHALSDAKLVGNILVLTVESFAAGQGHSNSGNHDSPKALVKHHYHASLWPSRHPRYSHPAFGMVEECNWNRECVDTWDANKASFPSFPAEEQARLIAVHDEFLKEKSDKEAAERAAGERQEADRKQNEILEACAEQLRGFAKEQEASQQPAQPEPAQPEQPAQEPVQQTETQPPAETPQKQPSPEYQLHTDDEIRHTDPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV04</accession>
    <name>A0A194XV04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_703232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078321.1">
        <property type="nucleotide sequence ID" value="XM_018217308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV04"/>
    <dbReference type="GeneID" id="28827034"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703232"/>
    <dbReference type="InParanoid" id="A0A194XV04"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="482" mass="54798" checksum="49EA69338F263E29" modified="2016-10-05" version="1">MDNPNTSLWRTVAVAILLYFATRTFYRLFLHPLARFPGPKLAAATRWYEGYYDVIENGQYTFKIEEMHKQYGPIIRISPYELHVSDPVFFDVLYCQEGRWNRYPFAWDAWGAEGPTIHATQHDLHKARRQPLAPFFSKAKVSSRQDMISRHVSKFCDRLSNIAEAGKMVNLGAATTALARDVAFDFILGKSYNSLDSENFDVAVLHAAQGAGSLWRLSKHIGYVLFLLQAMPLDWAMKIADDDMKTFFAHMKAAMNDTKDIMDEALSPSPPEGVKRTIIHEILDSKLSSHDKYFKRVFQDVTSVSGAGFETIGGALRLIFFHVFSNSAILQKLREELDSAKAKHLDVNELKVLEQLPNLTSTIKEGLRLSPGIGTRMARIAPDRDLFYKEWRIPAGTPVGMTTILMHMDENNFPNPRSFSPERWMDNNRQKNAEKAYAPFSKGTRMCLGMHAKAENFEFESDQFVIGTKGKGLLEAHVNLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV69</accession>
    <name>A0A194XV69_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078580.1">
        <property type="nucleotide sequence ID" value="XM_018219133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV69"/>
    <dbReference type="GeneID" id="28828859"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727257"/>
    <dbReference type="InParanoid" id="A0A194XV69"/>
    <dbReference type="OrthoDB" id="3557378at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="229" mass="25967" checksum="9E4EBCFB630D3933" modified="2016-10-05" version="1">MEMSIPRDARTRTWDIHGKQNVWNWKVSTDADEILYQTRFPCKHLAMMYRGAGESAQLLATIETGAHSWEASITFPQDDRIMAAPEPITMENISDEGMSTRWPVKVQALGGQELHWEYEHPAVGDRDLRLEDPLTKDELGNANSNFLSLSEKLPEAAVEELVITGTAAQIMLASLMHNDMTIAADGPEGHAQWKYQEPEWWENEGDEEQEATYEHHENETDELGESKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVP3</accession>
    <name>A0A194XVP3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_22016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078755.1">
        <property type="nucleotide sequence ID" value="XM_018205935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVP3"/>
    <dbReference type="GeneID" id="28815661"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_22016"/>
    <dbReference type="InParanoid" id="A0A194XVP3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="26353" checksum="AE9B21FE665B25B2" modified="2016-10-05" version="1">MTRYHNVASLYLGFQKQSSEPFLRFQHKIRSRYHEILSTRIAQVPLVSRLACYPSNVENFTRIVTNLAATQHIFELRFTSPFIHPNPAKDDYVPAIQERKRAVKYSLQSDGYNLVRRDLMRQLGDVTVLRTVHNRLIKGHPPLPLFHALRYDSQAKIAAKSQMTIVKRLNREQAFKEFDKIRKIDATKEFGVLVADSFILIYNQTQEEHDAKIFPTKIRIPFLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVT3</accession>
    <name>A0A194XVT3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_703330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078474.1">
        <property type="nucleotide sequence ID" value="XM_018217313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVT3"/>
    <dbReference type="STRING" id="149040.A0A194XVT3"/>
    <dbReference type="GeneID" id="28827039"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703330"/>
    <dbReference type="InParanoid" id="A0A194XVT3"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="341" mass="38145" checksum="3CCFC9123BBE5A81" modified="2016-10-05" version="1">MFSSSVRRVARAAPSVPITPSLSGATPRTIALSYRSHQRRLSSSKPSSPADGSTPPAARVSKKKAREVAANATVKGRDASLLHLPSVPSTQHVPEMQIYASSFFSLHRPISLTKSFPQTVTDDTFAAIFTPRIRVNKPSEVISTLTNTVKNLDSITGKKGAGRTQQVWNEERDDMRAAITEESYRQAVHLDTLPENAAEFTKQLMSSGSRYKPFNPPPPPEPMNSAESLAAGAEAAEALEPQHRTYTAVLTIEESTDENGEVTYSAHSSPLIEEAPRAGPTKFLERMQIRQERYRDREQRRGGNDMLAISVKRQRKLKMKKHKYKKLMRRTRNLRRRLDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWG8</accession>
    <name>A0A194XWG8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative U2 snRNP component prp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_604449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078427.1">
        <property type="nucleotide sequence ID" value="XM_018210357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWG8"/>
    <dbReference type="FunCoup" id="A0A194XWG8">
        <property type="interactions" value="1021"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWG8"/>
    <dbReference type="GeneID" id="28820083"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604449"/>
    <dbReference type="InParanoid" id="A0A194XWG8"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
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    </dbReference>
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        <location>
            <begin position="244"/>
            <end position="372"/>
        </location>
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        </location>
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        </source>
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        <source>
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        </source>
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            <dbReference type="Pfam" id="PF22646"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1228" mass="136150" checksum="5530B330D840D467" modified="2016-10-05" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </submittedName>
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        <name evidence="2" type="ORF">LY89DRAFT_410969</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="253" mass="27656" checksum="2C8C0AA2B407FF4E" modified="2016-05-11" version="1">MLTIYEKREPQTIGPISRTNQITPVEPTHHHHRTSTVYVTVTEIPYVSTSTPHHHPHSVTTYTIIVSSSTDDSYPSPTGTVIETTVTLPFAPTSTGSDIDATVTLPFISSATETDDATTVTEFVINTPTPLAKRDAEPQLPDSFTLGWPISATYISPPKENPCQNNIFAPPEWCSNGSPTFGITTVTVTYTGTVFENTATLAPLTIGEPGWGRRDKRSRLRAEVEEKERRQQLLGTQTRSFTYAPGTSAPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2B5</accession>
    <name>A0A132B2B5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_632659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060885.1">
        <property type="nucleotide sequence ID" value="XM_018211312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2B5"/>
    <dbReference type="FunCoup" id="A0A132B2B5">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B2B5"/>
    <dbReference type="GeneID" id="28821038"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_632659"/>
    <dbReference type="InParanoid" id="A0A132B2B5"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="16">
        <location>
            <begin position="101"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="17">
        <location>
            <begin position="515"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ06530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="714" mass="78854" checksum="945AF64CFE3F68E2" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2Y9</accession>
    <name>A0A132B2Y9_MOLSC</name>
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            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_602968</name>
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    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060968.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2Y9"/>
    <dbReference type="STRING" id="149040.A0A132B2Y9"/>
    <dbReference type="GeneID" id="28820001"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602968"/>
    <dbReference type="InParanoid" id="A0A132B2Y9"/>
    <dbReference type="OrthoDB" id="5410741at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
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    </dbReference>
    <dbReference type="Pfam" id="PF13358">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12850" checksum="E48C2CF4F812CC0D" modified="2016-05-11" version="1" fragment="single">WLFQEDGDPSHGMRKRGLAQQLKENNWIINLKHPAQSPDLNLIEAIWNIIKQRLRHRIFQSEEEIKEALQEEWSKVIMTEVRKRISQMPRRCARLINNGGKPIKTALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B564</accession>
    <name>A0A132B564_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_691640</name>
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    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Leotiomycetes</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A132B564"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287864" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="7391" checksum="35C6F7F89097478C" modified="2016-05-11" version="1">MKFLLLHIILAAASVASAIAVPSTVADTNIEKRGWGAACLLKCASVSGNVAEYAACLAACTAQGVPDGAVTVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B577</accession>
    <name>A0A132B577_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4220 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_661410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061182.1">
        <property type="nucleotide sequence ID" value="XM_018212603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B577"/>
    <dbReference type="GeneID" id="28822329"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661410"/>
    <dbReference type="InParanoid" id="A0A132B577"/>
    <dbReference type="OrthoDB" id="3549551at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287868" description="DUF4220 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50482" checksum="2EBD512B4EE25BD5" modified="2016-05-11" version="1">MATRRTLLSLASLAMLIYPSAEHTFKPNCSLPNESSYLVLSADIRGTFDILWSSLFTLLICTWTVQHPNIPPQGSQNGFDVEYVLSSAWRKAKWMLLTLILPEFLVGKALQDNGRAKRSIINLSELANVSGIAWSTTHGFYADMGGFVLKARQQRNGENVPAPIFLNCESLQFAFIGDGNRSLIEKIPHISKKDIQDKSKGDFFVKATAVVQVCWMVVQTIVRGAKGLAVSQLEIAVLAYSACTVITYYLYLDKPQNVQVPTYVLLKKELGGEKLTPEHQEAIRDCRPRSWFTVSLRLFRYQGAGKERRNILDPIPNDARYDDVKSALFTAKSLFTRMDDGFVIAGLVFGSLHCAAWNFDFPTPVERLLWRICSVITAGTLPLYYGVLLYDIHIKSLAIQRLPLVTIEVVLALGYVMARLFLIVEVFRSLFFLPPSAFITTWSSQAPHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B591</accession>
    <name>A0A132B591_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_702482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061768.1">
        <property type="nucleotide sequence ID" value="XM_018217256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B591"/>
    <dbReference type="STRING" id="149040.A0A132B591"/>
    <dbReference type="GeneID" id="28826982"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702482"/>
    <dbReference type="InParanoid" id="A0A132B591"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="40702" checksum="8CBB2C067D737E38" modified="2016-05-11" version="1">MKEAHVSAETTVSLHEVPIPTIIHPYSVLIKVACTSCNPKDWKLPTATLMTIHSCPNSGDDIAGTVVSVGSSVLSFKPGDRVAALHELGTPHGSYAEYAVAYEWTTFHLDDGMSFEEACTVPMAAYIGVIALCGMLRVKAGPWEIVEQSVKKGEKEGEPLLVYGASSAVGASVIKLAGIMGIHPLICVAGRGGTFVETLIDESKGDVIIDYRQGPEKVLEEVKNTLGGKKLKYVFDAISENGSHENYWRAMDVQEGSVTFVLGGHREDILESIHQSTTMAGSLWKELQPLGEKDRLGIGAGGKDFGFAYSRLIGSWLQERKLKIHPFEVVENGLRGLEKALKTLREGKSSATKYVVRIADTPDLRSTEKPESQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5P8</accession>
    <name>A0A132B5P8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_789646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061928.1">
        <property type="nucleotide sequence ID" value="XM_018223282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5P8"/>
    <dbReference type="GeneID" id="28833008"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789646"/>
    <dbReference type="InParanoid" id="A0A132B5P8"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="370" mass="42489" checksum="19066D17D7B6CA17" modified="2016-05-11" version="1">MSQTQTSTISAERLGKIPQYIQFPETIHELDWADLATLDLSKFNTPEGKQKLAQQLQNAIQQIGFFYITNFGLTQEEVDPQFAIGKEFFNLPTEEKLKYRADLENGGYNGYKPRGLREIVPGHFDNTEIYNIPKFIPQYERPHPALIKENWPEIEKFGRFIHHEIVSKLLVLFAIILELPEKYFLERHRYDEKSDCHLRYMKYHHRTAEENEKLNNVWVKGHTDFGSLTLLFRQPVAALQVRTPQETWKYVKPYPASITVNIADSLSFLTNGYLKSSIHRVVAPPPDQAHLDRLGVLYFVRPEDDLILKPIESPLLERLGLKGEGGDGVHLTAGEWVKARVAKNVNKAGGSKEASGEQEIIKGVKAKYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B633</accession>
    <name>A0A132B633_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062215.1">
        <property type="nucleotide sequence ID" value="XM_018220847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B633"/>
    <dbReference type="GeneID" id="28830573"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742626"/>
    <dbReference type="InParanoid" id="A0A132B633"/>
    <dbReference type="OrthoDB" id="10439413at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287902" evidence="1">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="82" mass="8933" checksum="388D07C5BAF8472A" modified="2016-05-11" version="1">MRLTILVTALFLALAHAIPVDDTADVALTAAMQSTIDLANAVLQQAGVEQTERACDINFRKCYMRCTGAPTCYAVCFLKYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B679</accession>
    <name>A0A132B679_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_344189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062273.1">
        <property type="nucleotide sequence ID" value="XM_018206872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B679"/>
    <dbReference type="GeneID" id="28816598"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_344189"/>
    <dbReference type="InParanoid" id="A0A132B679"/>
    <dbReference type="OrthoDB" id="9987011at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="302" mass="34260" checksum="70B1F709E7719725" modified="2016-05-11" version="1">MDIGHSTITQVMVEEPAEYQKESSFSLIQHDLFEITLNGPALVLTILAIIISIQILQPSFTCTLLALAPLPWIIHNDYQNFINLGPGGTPSTFLGYLKIAFLRMFALSDPYTPAIISEKIYPIIGYYQKSHSWLPERAGPRPKIAGIAPQRQIDQAGCPEMYQKLRQTLERLALQQPDSFRTAMSCFEKKGLALFAQKPINETCRGEICHVHHSDRSMHMNLHPDDAKIVLEKGWGERHPLARGGWMKQYVPREFLMIYAPRNRSELDVVCRIIEAAGFWVSGEHFKLKVENEPTSSKNTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6B0</accession>
    <name>A0A132B6B0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_659557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062297.1">
        <property type="nucleotide sequence ID" value="XM_018212519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6B0"/>
    <dbReference type="STRING" id="149040.A0A132B6B0"/>
    <dbReference type="GeneID" id="28822245"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659557"/>
    <dbReference type="InParanoid" id="A0A132B6B0"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="28281" checksum="A6A653EBEF70533E" modified="2016-05-11" version="1">MSKKAAVPDAWDDDWESQADKADAAAEVEKAEEEVKVTKAERLARHDASMRKVWESASPEPEAPFFLATRDTVPLKTEFKPTLKLLSRKPASKVIQKIDPVTGLAKMTLEDDDDEEEQKKDQPTPEELRARAQREREEKQKRYNEARERILGPSSGGSSPGTVTPPTEDARSRSGKGRARGNGRQENSRPQSQSGSKELFDPNYTPKPGVSIQKRAGDVARSGRSTPRDDDQVIRAPKGPDGNGKGFGFANRGGKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B860</accession>
    <name>A0A132B860_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Family 71 glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_599945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062534.1">
        <property type="nucleotide sequence ID" value="XM_018210126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B860"/>
    <dbReference type="STRING" id="149040.A0A132B860"/>
    <dbReference type="GeneID" id="28819852"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599945"/>
    <dbReference type="InParanoid" id="A0A132B860"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="52212" checksum="0744E15683C3A5AB" modified="2016-05-11" version="1">MVSTPTTNPELSKPSRPPESIQDAHKLPTADDFLSHFTAVTQIKGMTMSEAKSSCSWEVSEEVNFQYGNDSEWAVQDRADEELEFRRNQWHHFINNELLPYESYKDRFNGRGIVIVAGNGKSLKRVRVILRQLKSLGSRLPIELHYWGDEFPTKAQKEMSTLWPSMYFNDLSSSSNILKSSNDNFFHINYQLKTVAVMNSRFAEPLLLDSDNIPIIDPESLFDSDTYKEFGTLFWPDIARTRPNNPIWAITNTQCRMDEYEQESGQLIVDKRKFFYHLQLAAWFNNVHAQYYNEFLLGDKDMFRFAWHALKTKYGTPRKWVTSVGTVAPNGYYCGHSFAQHHPNGSVAFLHGGLLKTIPKAVMKWERESRGGIFQAYKRSVVDERHNLIEKVAISMDGVPYLPNRPEDLGIQWCTDLKDVHPRKLDELVPGFEKTFEDLGGYWMLDNDGTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8P0</accession>
    <name>A0A132B8P0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_741608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063127.1">
        <property type="nucleotide sequence ID" value="XM_018220730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8P0"/>
    <dbReference type="GeneID" id="28830456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741608"/>
    <dbReference type="InParanoid" id="A0A132B8P0"/>
    <dbReference type="OrthoDB" id="3564193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287978" evidence="7">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="20643" checksum="704E613A9E1F8E94" modified="2016-05-11" version="1">MHQQLLPALLILPVITLGVEFINPPPFQSTNDFSLNTIYIEGSLVNIEWTAGPPGNDTSLSLWQFDGTQYLRLGDQSVGSSNTSTTSAAIGSIPASPSTLPAPAAPTASEQATPTPSSSPESSSGLGAGTKAGIGVGASAAGILAVGAAAFLLLRRKRKQDVTAPSEEQQKSQVQELEETRIFELQEDPGPRDGTTVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B907</accession>
    <name>A0A132B907_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_676772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063243.1">
        <property type="nucleotide sequence ID" value="XM_018213624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B907"/>
    <dbReference type="GeneID" id="28823350"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676772"/>
    <dbReference type="InParanoid" id="A0A132B907"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="183" mass="22226" checksum="77C158254A84CD04" modified="2016-05-11" version="1">MAKRIWSWRKEQLIPFCCHLDLVLRNYIVCNYDITTIIIAQAHVHHPYRYSSFQFRIAMKFHLPSKTQSTTIHQTEINITEAKPTVKTAWSELRQQIICKMEHQAKEIVRNETRRRLKSILKRWEHVAWEDKRWLVANLMTTDEDIYTRIWRGAIEVDERARFAEREERRRLANGVQAMRWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B990</accession>
    <name>A0A132B990_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_741660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 120377</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:fatty acid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
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    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="612" mass="67695" checksum="CDAE877A2C386BC8" modified="2016-05-11" version="1"> </sequence>
</entry>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9T2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063438.1">
        <property type="nucleotide sequence ID" value="XM_018223173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA09"/>
    <dbReference type="GeneID" id="28832899"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788489"/>
    <dbReference type="InParanoid" id="A0A132BA09"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="732" mass="79893" checksum="CC4B875B8E763995" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAY0</accession>
    <name>A0A132BAY0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_724021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063935.1">
        <property type="nucleotide sequence ID" value="XM_018218863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAY0"/>
    <dbReference type="FunCoup" id="A0A132BAY0">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BAY0"/>
    <dbReference type="GeneID" id="28828589"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724021"/>
    <dbReference type="InParanoid" id="A0A132BAY0"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="149"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ09580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="705" mass="79180" checksum="37BD8784090F9CC1" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB74</accession>
    <name>A0A132BB74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_761301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064027.1">
        <property type="nucleotide sequence ID" value="XM_018221542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB74"/>
    <dbReference type="GeneID" id="28831268"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_761301"/>
    <dbReference type="InParanoid" id="A0A132BB74"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="26801" checksum="53F996B2499B4C4D" modified="2016-05-11" version="1" fragment="single">VDLIRCRATSRRTHRFCVEHISIDKAGQVLYLKDPCYAHHRCKHITINADGEIDRNQLPYRESITFLEPRDEEPTPIRGTSENSISLLGRCFGRCLTRTHTSVKNFNSNSTDVYCARASHFRISLTTSMLEYSDSGSNTDTANGEPGSNEEHTESGQPEASSSDHEQEKTSSKTTGTPENDEKAGCPWWVKYLYGVNSLPCAHCRQVASNPIKTGEGIASLIIYSSQAHGSPVGVRIREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBE3</accession>
    <name>A0A132BBE3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_275867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064053.1">
        <property type="nucleotide sequence ID" value="XM_018206411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBE3"/>
    <dbReference type="GeneID" id="28816137"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_275867"/>
    <dbReference type="InParanoid" id="A0A132BBE3"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23455">
        <property type="entry name" value="beta-trefoil_Ricin_RSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012791460" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="76"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="21190" checksum="8FD4EF53F1E07998" modified="2016-05-11" version="1">MYFLQLALFALPVLATTGSRNTPKKHHSQKQSYAYKGPGQYYIENQATGTTMDLYLGDAGPDTAITAYEPTKDNAHQIWQVVAAAQYHQVLIINSATGAIASCPSETNDDGLYQMKGGEVAIDGYSLFTLSINKDKSVQFKNVQDPNLCIDLQGPSDEDGTPIICYSCHPGEGKNQNWIMVPVPKVGDGDGELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBK4</accession>
    <name>A0A132BBK4_MOLSC</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_740846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064131.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBK4"/>
    <dbReference type="GeneID" id="28830372"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740846"/>
    <dbReference type="InParanoid" id="A0A132BBK4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="132" mass="15148" checksum="1634FC3037207954" modified="2016-05-11" version="1">MNADFMIFTLWLVHYDPTGNEFKYSWLPYLSRHKEGSEGLWRKTRGGESGSQGQPQSASSVDDAHCWTQPLRFRVLMAKVDENGEVQERGGNADAEEEAEITKWTHLDYVQVFDPLTDSIPGNPAHRPVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBV8</accession>
    <name>A0A132BBV8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_266074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064265.1">
        <property type="nucleotide sequence ID" value="XM_018206310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBV8"/>
    <dbReference type="GeneID" id="28816036"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_266074"/>
    <dbReference type="InParanoid" id="A0A132BBV8"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="136" mass="16114" checksum="91F7ABCB59C218C1" modified="2016-05-11" version="1">MKLWVLASRLRMARLQDQAIDMLEMRIRLDDMQIETKYFGFVYNNTVPGDALRRYIIDFCVSSSFESGVQDVFPWELRHDIFEEELMKKEVDSTGIHGYHVVEESGEVSRKERARNQSGRRKEGDYHYHSMVLANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCP3</accession>
    <name>A0A132BCP3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063782.1">
        <property type="nucleotide sequence ID" value="XM_018216101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCP3"/>
    <dbReference type="GeneID" id="28825827"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690438"/>
    <dbReference type="InParanoid" id="A0A132BCP3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="106" mass="11580" checksum="F36F4D40C4069095" modified="2016-05-11" version="1">MQSRLATNRPGHSNPSLESLPFPIILPMHFASNTMSSCSPSLNLHPLPPTPPDLQGTPQRLQGLSPFPSLPSKHAHPEDSLSRTDHPVPVPDLIIPRSRNATLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDR6</accession>
    <name>A0A132BDR6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_267533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064329.1">
        <property type="nucleotide sequence ID" value="XM_018206327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDR6"/>
    <dbReference type="GeneID" id="28816053"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_267533"/>
    <dbReference type="InParanoid" id="A0A132BDR6"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="65494" checksum="70B118333FC31BC3" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BFP4</accession>
    <name>A0A132BFP4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_675356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064892.1">
        <property type="nucleotide sequence ID" value="XM_018213502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BFP4"/>
    <dbReference type="STRING" id="149040.A0A132BFP4"/>
    <dbReference type="GeneID" id="28823228"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675356"/>
    <dbReference type="InParanoid" id="A0A132BFP4"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF7708"/>
    </dbReference>
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        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="5">
        <location>
            <begin position="145"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="366"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="856"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1182" mass="132974" checksum="A6ECA148FE0432AB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRI4</accession>
    <name>A0A194WRI4_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_626059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ10618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064973.1">
        <property type="nucleotide sequence ID" value="XM_018211092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRI4"/>
    <dbReference type="FunCoup" id="A0A194WRI4">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRI4"/>
    <dbReference type="GeneID" id="28820818"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626059"/>
    <dbReference type="InParanoid" id="A0A194WRI4"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="594"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="333"/>
        </location>
    </feature>
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            <end position="496"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="423"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="903" mass="100156" checksum="E808F0BF6FDD8E27" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRR5</accession>
    <name>A0A194WRR5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRR5"/>
    <dbReference type="GeneID" id="28825615"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689331"/>
    <dbReference type="InParanoid" id="A0A194WRR5"/>
    <dbReference type="OrthoDB" id="4157259at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="136" mass="14993" checksum="8EDBC1C3713AD7D7" modified="2016-10-05" version="1">MSSSITIPPRAGESSKAAAAPSSSSSSSYSSSPRTPQQPQQSATPASSRPKYGHDRRPSLLSSSLSKQEHTVINIGDPDGVPRLITCVRSSQGYEWNPEIFLPSYVECDFESLERKRDPVHEIRLSDEEIKQMFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSB1</accession>
    <name>A0A194WSB1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_674966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28823202"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674966"/>
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    <dbReference type="OrthoDB" id="2370295at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="509" mass="57443" checksum="B5809AE9AEE82559" modified="2016-10-05" version="1">MQPATSAYQQDPLVEARLNKHQHAAVACLLTHEFHKLDPATGDASCQVRAIIVLIFHQNLKKWLDDIWDNAVKLSQDYNYTHLGDKPDTKTKTITEIQGADHSKDFDDLVNVVRDFLGEEDFELLGLTYSLCAAGIAGLDEFDIDFRHRSNNLWGSHEKSLKARLAKLSCATFIKFAEEVHSNGKLIDVLQETRSVIKNEGADDVPVLSIQATFLTALAILYARGIPIVNSIIRIQINGDGQSQHHTYTFGNARSFIYLANHQTGKFELLKNPSPEQKCCPAFYIKSWSTYHANSTSKSLYSPDHKLYYHDFAKISLLWAVIVYSAAHPPFSRRAERVDLDLTSAYEGIDGTIQSDLALQHDRFDLEGLNYENLVSRSSDRPGPNLATKHKFALEVANQHQLNEECQFVRMGAPSTECTWRITKPIDWQIAHASAATVSWVDNRLEGLAERHRKASNAIIGRFVFSLGKLGASHVDRSRATELHNTKKETVRRKNYLADYPQNESLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSR4</accession>
    <name>A0A194WSR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065341.1">
        <property type="nucleotide sequence ID" value="XM_018220535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSR4"/>
    <dbReference type="GeneID" id="28830261"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739952"/>
    <dbReference type="InParanoid" id="A0A194WSR4"/>
    <dbReference type="OrthoDB" id="3545605at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="47033" checksum="CF50508046494983" modified="2016-10-05" version="1">MDSSTPTPRPSKTRVTIKLNLAPKDPKPDSEPVTEAEAQFESEIDLEDDIEPESPTPSRRQPHREAKLHVLWRDLNAGEVSAVYPWYPGSQLVQHERDSPDAMDESRGSPEMEDNATIAEDPLAGIKLRKLPVGLTSRDIQDPEERYKFETKMQLASSTATMVMNLDNEQIMRFLVEIKACPFTTYLDANRVLRSITETMVTFGVEDMIREGYIKGATDYPINQHNPTQAVDAYAVMENIYRSASNTRGEINSYASLDPENENKMRWHRSLYHDVRAKNIIAGIEKVEQKWKSITPRRYRTISTLRLAFDYLSNIYHPTYPWPCSHAYFEATLEMIRINEIYCMLVFEEDKYSFLEGLRKAMVDAETRRMKEWIEARSDEQFFDLMGTGLAPDFEDSLEGALNPYNSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTA0</accession>
    <name>A0A194WTA0_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_739890</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065264.1">
        <property type="nucleotide sequence ID" value="XM_018220522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTA0"/>
    <dbReference type="GeneID" id="28830248"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739890"/>
    <dbReference type="InParanoid" id="A0A194WTA0"/>
    <dbReference type="OrthoDB" id="3554680at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="283" mass="31873" checksum="1149A1C53CCE78FD" modified="2016-10-05" version="1">MEIGSFASQSSEERETLRNNHYANWTKYLDSFKQYESDVKDVKQTVRVSNQTSSHLEGMRTSALAIGSMNAAAYPTDDDDEDDVIVKPDKCPKYSSEVEQIDSSSPDDCFFPGFKVVKFGSDFIGKCSICDRTSIIALVLKVKDKANFMNLNRKTFSRFLSSMDIYDLFYKRICCDACASYLIEPNAGLLPVPVSGAVALLSPEDNMDLWVEMLNGIFSGVRVDIPKWYWVEYLRRKIIELPADDSTTIEERLFKDALTWLVRGFNGEIDGDGDDASSQVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTG8</accession>
    <name>A0A194WTG8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_252084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065262.1">
        <property type="nucleotide sequence ID" value="XM_018206208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTG8"/>
    <dbReference type="STRING" id="149040.A0A194WTG8"/>
    <dbReference type="GeneID" id="28815934"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_252084"/>
    <dbReference type="InParanoid" id="A0A194WTG8"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="729" mass="83027" checksum="557FD419892380A1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTM5</accession>
    <name>A0A194WTM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_759226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065663.1">
        <property type="nucleotide sequence ID" value="XM_018221458.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28831184"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_759226"/>
    <dbReference type="InParanoid" id="A0A194WTM5"/>
    <dbReference type="OrthoDB" id="5419308at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="29800" checksum="555753338566888F" modified="2016-10-05" version="1">MISSGPMIRISCLGDSLSMVWGLLERQVRTCIKVTSAEQISQCHSSISKIHQRSQSSFIPVFQNFVSQHIIFFPTMYFSGAAIFAAFSFATQVFAAPSTTSTLAKRSDFVTTLQTTMNSMSSSINSSANALNASAASNGGKPTLMTSFTVLGDIGGTLTNGLGSITQLIEDPIIDFSIEEIQVLVEVLDVWAEILEVVEGIVDAVVNAFFPGLVDEFKPFIQIWINVVDAFTNPFLDFYSELVGTLTGSPELAAEINDYIAVIEKIRDDFLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTV8</accession>
    <name>A0A194WTV8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_655216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065745.1">
        <property type="nucleotide sequence ID" value="XM_018212334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTV8"/>
    <dbReference type="STRING" id="149040.A0A194WTV8"/>
    <dbReference type="GeneID" id="28822060"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655216"/>
    <dbReference type="InParanoid" id="A0A194WTV8"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="23703" checksum="E28D0A6D092FE3E3" modified="2016-10-05" version="1">MTTPQSLHHALLRPCILHILRAAGYHTTRPSVLDTLTDLAARYMLMLAQTTANHAALNHTEPELALEISITDVRMAMQDCGALAPENLLEEQEFNGQEDLRGVEGFIEWAMGAGNHEIRRVALEGPEGAKEDYLTALKKKHSAADEESRYNGTVLGRPTEPRAVKVEGSDITSLKEWAERLRKPPAPTSVQTSSSRRQSSALSSLGDEVMLDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUB5</accession>
    <name>A0A194WUB5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_758259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065910.1">
        <property type="nucleotide sequence ID" value="XM_018221432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUB5"/>
    <dbReference type="GeneID" id="28831158"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758259"/>
    <dbReference type="InParanoid" id="A0A194WUB5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="55576" checksum="AE113D6BF7A14ED3" modified="2016-10-05" version="1">MLPTLKLLSKHRAAVGVAAVASTAFALFGYDTTIAGGVIALKSFQVEFKLSTNAVKSADISSNVVALLNSGAFFGALAPALLSRYIGRKVLMTIAACFMLLGGTLQTSAQPPSISMIYGGRVISGFGVGIVSSLIPMYIAETAPKQLRGLLMSFTELSLVLGSMVAYWTVYGCSLHLKPTSKQWRVPLSLQVVLGAIILSGSFIIVESPRWLGKQDQWDEAAKALQWLRGASSSEEVRVELAEIRAQIEEEIKATSGRSIKELFQRQNLFRLFWACGIMVLAVGTGQTAILYYAPTVFKQIGFTGQNPGLLASGVFTVVKVVATILFLTLVVQNFKRKHLFLFGSALMAIMLFTLGALLKTHPPITGHAANNSSSGRTMMATIYIYIIGFTVSWGPLSWVYVGEIFPTRIRDYGMAIAVMVIWFFNFVISKWTPLIFLNLTWKTWMLFGSFNAIGFIFAIFLPETKGLSLEEMDVLFGLVDESTRRLDIEEHLGVITDTTMIGMEKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUS2</accession>
    <name>A0A194WUS2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rhomboid-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_654445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066066.1">
        <property type="nucleotide sequence ID" value="XM_018212303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUS2"/>
    <dbReference type="STRING" id="149040.A0A194WUS2"/>
    <dbReference type="GeneID" id="28822029"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654445"/>
    <dbReference type="InParanoid" id="A0A194WUS2"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="132"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="32345" checksum="F80DED8EB57EEFFF" modified="2016-10-05" version="1">MSLFSRIVLPSARINLRTSQRLYRPFTSSVLRLNKYNRSPRKTNRSRSQEQRVQQDVSDQYDQNNFEPPPRRPHVNSGKIVVGGIIAACAGVYIYSVNLEVQIKSNFSNKAKENIEWFRKHFVMSYESIQNGRYYTILTSAFNHVSLMHIGFNMIGLWGFGRSIITLFGVPTFGIIFVGAAVTGGIAQYSTWQCNKGYHKAVVGASGAVFGLVTALTFVMPRHSIILGFVPMPMWTALGISVAASIAGLQGVWGPHLGHADHLGGMAFGALFWLLVLRRRPRGWMPYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWT4</accession>
    <name>A0A194WWT4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_624407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
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</entry>
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                <person name="Seifert K.A."/>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="3 4">CBS 120377</strain>
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</entry>
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    </dbReference>
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            <end position="1166"/>
        </location>
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        <source>
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    <sequence length="1166" mass="126255" checksum="835475BFD1731501" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_622073"/>
    <dbReference type="InParanoid" id="A0A194X077"/>
    <dbReference type="OrthoDB" id="5394869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="182" mass="20034" checksum="E4ECF7C1AAFD81AA" modified="2016-10-05" version="1">MSKVRGIFPLFLATTFGIVNGIWVFGPAFREQQENDGQVKTELVVSGQVDNARVEQLRDVEAAINRASANKSILQPAEKQSSWWTTLGDWSRGSRNDNTREMKSATPNSNIPTTPDRISPTNVPTSSPTLGIANTPTLAQKLVEKAAEDPDLKMLLKTVAEGGGSSEELKKFQRHLDDIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1I6</accession>
    <name>A0A194X1I6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_708957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068199.1">
        <property type="nucleotide sequence ID" value="XM_018217719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1I6"/>
    <dbReference type="STRING" id="149040.A0A194X1I6"/>
    <dbReference type="GeneID" id="28827445"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708957"/>
    <dbReference type="InParanoid" id="A0A194X1I6"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50816" checksum="591B156D6690AB24" modified="2016-10-05" version="1">MLRPAAWQEAMPNDTGSDADRLKARGGASLRNFHRRLRALLLFLSLLIFLEILWTCSRSTPATRILKGGGGSELTNTYKQRVYIAALHYNDEELLRKHWIPSLLDLVQHWDPENVYVSITESGSWDGTKDALRDLDNELEKLGVERSIVVSNRTHEDEVTRKPAANETGWIQTPRGELEMRRIPFLAAQRNEAMKKIQQLASRTENPRVFDKILWLNDVIFKTDQVTALINTRHGDYAAVCSIDFSHPPEFYDSFATRDIKGQAPVTNFWPLFNAPESYKAVSTYSPVPVQSCWNGMVVFDAKPFYHEPTLQFRGIPDTLAAMHVEGSECCLIHVDNTLSKDKGVWLNPNVRVTYNEEANDVVNPEKGGWPTSSGKVQGIWRNRWAWWTGWPWRWYAERKVDRKLKAWELGEKAEGEALRNEPGRICLVDEMQILLANGWMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1K2</accession>
    <name>A0A194X1K2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_152621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068428.1">
        <property type="nucleotide sequence ID" value="XM_018205416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1K2"/>
    <dbReference type="GeneID" id="28815142"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_152621"/>
    <dbReference type="InParanoid" id="A0A194X1K2"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45927" checksum="50539BF3DF018F22" modified="2016-10-05" version="1">MRKAFSKFTDKLDGSKPSSGTNPAQGNTSHGPPPINYDSKPNRKIIYPQPGQQEPGPGQLPPKVASTQHHGKMRFFHPNGHEHIVSRDVGNSGVLDGKIVWGWGDTLMGAGGRGSKASICATDSTSIGHLSDRMCATDTALWDNNEFVANFIPCLPHEEKDGGLTKYAFGGSNVIEYAPNQGLLFFLKIHRPSGKNIIKGAGVASVTMEGHVPKCKREMETLWTKEEACYGDVGIAYDTRDGFVYAFGKGPQQDDEQLIRRTYLCRAPITRAFDISAYQYWHEDKRVWSPQRLTTHGQGGTAKITNEQAIFPYLAMDRSAPFWSNYFNKWMFLYGNSWGYSDVYVMTADKLEGPWDKHGDVIVASTQPEGGKPVAGEFRYAVNGHPEWDESGKTVFVTWTKLNEIYGTTIVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X284</accession>
    <name>A0A194X284_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_784274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068661.1">
        <property type="nucleotide sequence ID" value="XM_018222769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X284"/>
    <dbReference type="GeneID" id="28832495"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784274"/>
    <dbReference type="InParanoid" id="A0A194X284"/>
    <dbReference type="OrthoDB" id="3546297at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="334" mass="37344" checksum="340744B181B8DB57" modified="2016-10-05" version="1">MDSAASGAVDPKKACRELFNMYQESFNQMMENLKKCHGEAAPNEETTIAAQAVTETAGTNAGSSIVQEAEADEEAEKTEFMKKLEMPSALLNLPKEIADERLKQLCFTRDGPKIPRDVPRAADSNDRYQIPLINLCELQRLSLYAMRQELTAKAIKIKEDESLSGEEAGSIKTLISEYCNALRDFDYMREKDSDADRDPFYLTYARWCDWSVMKPKIASLYKGDPLYMLQVPRDTSDPEMVGDARGWAKKREDRRGFIMRLWFGLGGGLASIAPMLIVIQHRDRNTALVTASVGMLLFAMFMAYYHERDASPFALVGATAAYAAVLVVLVSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2U0</accession>
    <name>A0A194X2U0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_720529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068517.1">
        <property type="nucleotide sequence ID" value="XM_018218578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2U0"/>
    <dbReference type="FunCoup" id="A0A194X2U0">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="GeneID" id="28828304"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720529"/>
    <dbReference type="InParanoid" id="A0A194X2U0"/>
    <dbReference type="OrthoDB" id="3556181at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="209"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="388"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ14162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="648" mass="73769" checksum="5D4EC70ED91CA08B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3H6</accession>
    <name>A0A194X3H6_MOLSC</name>
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            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_686853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016166">
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    </dbReference>
    <dbReference type="GO" id="GO:0016117">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <begin position="18"/>
            <end position="518"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X457</accession>
    <name>A0A194X457_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018205199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X457"/>
    <dbReference type="GeneID" id="28814925"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_126514"/>
    <dbReference type="InParanoid" id="A0A194X457"/>
    <dbReference type="OrthoDB" id="3561305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14307" checksum="263EBE6A44F9C3B2" modified="2016-10-05" version="1">MVTVEHEIPSGMEYQYADHTISERPGPILKAGMGSTSQAEHPPAPSQGPNSGQYAERRRQFYIELDTIKQKKLSQASQRGGPNHALNDYQLQLEILELENKKRHLQRRIDQDAGQAIASPLVSKFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X474</accession>
    <name>A0A194X474_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_649578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069331.1">
        <property type="nucleotide sequence ID" value="XM_018212069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X474"/>
    <dbReference type="STRING" id="149040.A0A194X474"/>
    <dbReference type="GeneID" id="28821795"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649578"/>
    <dbReference type="InParanoid" id="A0A194X474"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    <sequence length="1149" mass="128855" checksum="C26FA2EB10D344A1" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ15338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11459" checksum="4421C037E89B2182" modified="2016-10-05" version="1">MNPLPLAPSSELAVTTLVAKQNFSANKGARPTFKILNLHRYYITDFPKNESTYVDFTLRGRISPEKQTALRCITAGSDWVEEQNFPLVHQIIFGIFQSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5G5</accession>
    <name>A0A194X5G5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">LY89DRAFT_588159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
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    <dbReference type="OrthoDB" id="4096362at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="36"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="35949" checksum="389741BCD906E7D2" modified="2016-10-05" version="1">MILAQLNRSATIAWDSRPRIPQEPTAIVSEPETKDPVAVSAEKEPVKEEHGLFHRTHTTEEQVVTIPPPRPVWGDISHNGWSSPTSPDLPSLQYTTVILELPHLIEARAVSLAPTNLQTDPPLPDARVVELLQRPAAMGLRDYIGQLSSMGVLTEPAATAEFLTQYEYARFSGRLLAEQQFRDLMGHFAELLRNMDTLGPAVLASLDIVDSDIDDDGSSTTPITPRSRSPNRSVSSHEGTIRTAPSRHTDTTPSKRQEFSTAPATPRSKKRVVSRSPSMNTFAQTRRPYAASSSSESLRSTSESSVIKLSRSNTPGDLPYTLNIPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5N1</accession>
    <name>A0A194X5N1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_783623</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15488.1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="23347" checksum="F53E2347B45B1619" modified="2016-10-05" version="1">MSKVTAISGFTWTSKLKKTTYVASAQKGFNLACLFSWTSRYSLYQNLSDRHFLQTQQTLIRSRCQLPAPQGLNLAPVPGLAPVQGRRPAAVLQPPRQPQVSRAPPVNATNPPTAVTTRCLSYNTGLGAELPGVAQRQVVTRAGLATDPTNSVRASHRSSAKGQAVGTLAPVACDLCAAGYGPYVDCVVALGTRANGKKFFGGGCASCTMGSHPERCSFYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6L7</accession>
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        </submittedName>
    </protein>
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        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SEC-C"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103642">
        <property type="entry name" value="Sec-C motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="25662" checksum="DAC81EC400FA258B" modified="2016-10-05" version="1">MSNLPSGTHVLSGIESQRLRAFCSSETFSASDLDDFAILLQNAEIEETKIPVFNFILQLTILNPPSRPRYLQIARYLALEAEVPVDITDLSGTTTFMYSISTKPYWDKEFAEIMLQGGAQVNQRNRYGCTAAHDIVMARDFSTEGKMKTFDALTFFVEKGGDLDIKDGDGVSARTIGKSVMRMVPELGFVINPTSGHPSMPTAGHGTTAGTKIGRNDPCRCGSKKKYKVCCGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7M9</accession>
    <name>A0A194X7M9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28824768"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685214"/>
    <dbReference type="InParanoid" id="A0A194X7M9"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="761"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="1144"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="214"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1466" mass="155274" checksum="D47AB5AFD9D78EA9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7W8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
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    </dbReference>
    <dbReference type="GeneID" id="28831627"/>
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    <dbReference type="OrthoDB" id="1076608at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
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        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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</entry>
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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    </reference>
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    <dbReference type="GeneID" id="28821666"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647041"/>
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    <dbReference type="OrthoDB" id="2276076at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052517">
        <property type="entry name" value="GlcG_carb_metab_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309:SF1">
        <property type="entry name" value="PROTEIN GLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34309">
        <property type="entry name" value="SLR1406 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="15555" checksum="308B91FAF7960649" modified="2016-10-05" version="1">MATKHQEMLTLEGAKIAIAASEKKAREIGVDMNIAIVDASTHLLHFSRMPNAKITSISIAMDKAFTAAGHRVGTHTYKEAVWPGGPAFGLGNTNGGRFTTFGGGLPITNSKGEVIGGIGASTGTPAQDQQVVQAGVDALEAVLSGKVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8S4</accession>
    <name>A0A194X8S4_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">Serine/threonine kinase 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_685496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070925.1">
        <property type="nucleotide sequence ID" value="XM_018215099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8S4"/>
    <dbReference type="GeneID" id="28824825"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685496"/>
    <dbReference type="InParanoid" id="A0A194X8S4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="68"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="548" mass="60663" checksum="83D2C236EEAF076C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X980</accession>
    <name>A0A194X980_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_63403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071080.1">
        <property type="nucleotide sequence ID" value="XM_018211373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X980"/>
    <dbReference type="GeneID" id="28821099"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_63403"/>
    <dbReference type="InParanoid" id="A0A194X980"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17101" checksum="525E445C8143CA25" modified="2016-10-05" version="1">MGMGLHCERSPRTLLHSHTFYTCCLTREGLLWSLSDFLIHGILQWSASTSGRRLLAPVPSFIALNSDKGFMPISEDVSLQVPNTHYLCTTLHYPHYTYASVSRSFLFFTCLSITSSLSRIETHYEAILISFFTRLHTSLPVVPSCSSFAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X984</accession>
    <name>A0A194X984_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-2,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194X984"/>
    <dbReference type="GeneID" id="28824681"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684805"/>
    <dbReference type="InParanoid" id="A0A194X984"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9729" checksum="9898CB79380B2D9D" modified="2016-10-05" version="1">MPWVVGGWHPLSCAYFPSYRDVIIRLKPIIMELERSENILIVTHQAILRCIYAYFMKEDQERSPWYMTTATFEEKRECCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA18</accession>
    <name>A0A194XA18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071371.1">
        <property type="nucleotide sequence ID" value="XM_018214998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA18"/>
    <dbReference type="STRING" id="149040.A0A194XA18"/>
    <dbReference type="GeneID" id="28824724"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685001"/>
    <dbReference type="InParanoid" id="A0A194XA18"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="2">
        <location>
            <begin position="77"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="490" mass="56270" checksum="C412651368B49BEB" modified="2016-10-05" version="1">MLSMQVPATGTSSPRTIPCRTAGLDRLGRTAYQHGLGYLWRNFESKVPGLFVDDATENRIGVVKAGRDQLHWVSTPEELYTTLSERMSTLLILNRYNSWSRIGITIHAFSVVCDFAAITPFFLHFLVGMGRKFSSKDEDFMSCYSTFVSENTPLVSSLGSGMEKHSDSLWGICYNIRYFEQHTRDLEDPWSCRQSALHHSFLAVSKQSTWVVIQPPKAFDLTVSSTQHPMSLHLRYLHACLANWREYLDSFAQRLKPLNQQIAIPNPYESFKINFSHEQYLHHLRGKLHYARSILNNTMNTFRVIAEHESAVAQEQSLCQAVHHEFQRELRNLSREVDNYIDTSQRFLRMADDLKSMYDNILTFHGQELQHDTSLKLAHLAQADASGNRDMAVLADLTQKDSRSMRIATAIAMFYLPVNLVMSFFSTTLVWYGTDATESQSSRMQLRSEVWIATVAAIVLASSTACWSWWWNWKDQKKPYKKAIQETAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAA7</accession>
    <name>A0A194XAA7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_685035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071429.1">
        <property type="nucleotide sequence ID" value="XM_018215004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAA7"/>
    <dbReference type="STRING" id="149040.A0A194XAA7"/>
    <dbReference type="GeneID" id="28824730"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685035"/>
    <dbReference type="InParanoid" id="A0A194XAA7"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="174"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ17074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="455" mass="52443" checksum="4FC6C65B5722008F" modified="2016-10-05" version="1">MAWRSPRYTRRAIRGFTFLSIVLFLLHSFGLLDFAARRYDTWPWTPCSASSLFAQSCTASRATIAQDIQIVVKTGGSEPQSRLRYQLVTILSQIPRENVLIFSDLEEEVDSYSVHDVYADLSEQERRSYPEFALYDQLQEYKEQGKDTRELQGGWDLAKYMNLAMKRKIWKMQREIGGEHRAKWFVFIDTDTFVEWDNLLELLEHHDPANKIYIGSPVWLPGLQFAHGGSAYILSYGALKALNSPYSHDQEEPLYSQYGLNVTELCCGDEALARVLKPKGVKLKGYWPMFNGETPATVPFGRDLWCEPVISLHHIAGEDMQSLWQWVEDWKVKTMNMHPLLFKDLFDYIAPQITSILEDWDNTDDSMKIYPTKKASHTTFDDCKGACEADKLCFQFVYNGTTCALSHHIRLGRARSSKGDGYGAQRYISGWNVERVRDWTMKTDCASAHWVRSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAR6</accession>
    <name>A0A194XAR6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_706916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071608.1">
        <property type="nucleotide sequence ID" value="XM_018217559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAR6"/>
    <dbReference type="STRING" id="149040.A0A194XAR6"/>
    <dbReference type="GeneID" id="28827285"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706916"/>
    <dbReference type="InParanoid" id="A0A194XAR6"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="383" mass="44082" checksum="4997CF0FA7691E8A" modified="2016-10-05" version="1">MGIEEALPHELRGKLRADLLAADDKFVLEIPKVELHVHIEGTLTLNLRWKLTQRNGTILRLVPNGPELHSLEELHAAMDSIMPDSSRMNNDEERDMFFESYFEGFQALKTEEDYYDLAMNYFEHAASMNVRYCEPFFDPQGHTSRGVSWSNMMDGFRKAQKEAEEKLNIKSSWIMCFLRDHSPESATEHYKAAQPYRDMIVGIGLDSCEEDRRPSLFEEVFAQARGDGFKLTMHCDVDQKNTPKHIRQVVSVVAGEGTDRIDHGLNASDDRSLIDLILKRDMGMTICPWSYLRHTTYAKLGQRIRALYDAGIKITINSDDPAFMDDCWILHNFLLAKHLCGFSDRDITVLARNAINVSWAEQSVKDNILREIEIVYDRFHSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB10</accession>
    <name>A0A194XB10_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">laccase</fullName>
            <ecNumber evidence="6">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_706965</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071716.1">
        <property type="nucleotide sequence ID" value="XM_018217565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB10"/>
    <dbReference type="SMR" id="A0A194XB10"/>
    <dbReference type="GeneID" id="28827291"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706965"/>
    <dbReference type="InParanoid" id="A0A194XB10"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268033" description="laccase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="379"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ17361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="531" mass="57940" checksum="5D54D134AC539418" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC53</accession>
    <name>A0A194XC53_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_669036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072100.1">
        <property type="nucleotide sequence ID" value="XM_018213062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC53"/>
    <dbReference type="GeneID" id="28822788"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669036"/>
    <dbReference type="InParanoid" id="A0A194XC53"/>
    <dbReference type="OrthoDB" id="3864156at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="238" mass="27750" checksum="A10EE4B1C0A90D61" modified="2016-10-05" version="1">MRHVLDVLVIDNSSILVADSENVYKNFIDRLTPHRIEKDLLDALDPDIAKLYQIGSLDFDTLQPLDHSKAERCNWPGIALHVVYDEEHYGISWFICEASLHLNRASPLRPKYNRKGVDEGNVETAIELRLGAKDLLLSHDPDIRAYFERRQGFYNLPMWRKLEGLRRGRTIQEQTHFRDITLMHRKHQTFENSDLARDADPEKGDVTEIWIQCSICKHANTTRLDRARYMMDFMFGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCC4</accession>
    <name>A0A194XCC4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">GPI inositol-deacylase</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_52882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071757.1">
        <property type="nucleotide sequence ID" value="XM_018208086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28817812"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_52882"/>
    <dbReference type="InParanoid" id="A0A194XCC4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="5">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="341"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="603"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1575" mass="177143" checksum="7D5FDBABA862635A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD36</accession>
    <name>A0A194XD36_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_58771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072022.1">
        <property type="nucleotide sequence ID" value="XM_018209445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD36"/>
    <dbReference type="GeneID" id="28819171"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_58771"/>
    <dbReference type="InParanoid" id="A0A194XD36"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="12836" checksum="2AA94FB3869D687A" modified="2016-10-05" version="1">MGIDSWLSLAGRTPELSDGPANLLRTAPALISRLMREFGDDFANFEFTATKGGLQIIQSLARELMQPLEDESLSEAEQIFTSVALLRIAKVALCIALESDTEQIRGYLSTDIQVYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD85</accession>
    <name>A0A194XD85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072474.1">
        <property type="nucleotide sequence ID" value="XM_018214805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD85"/>
    <dbReference type="GeneID" id="28824531"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684045"/>
    <dbReference type="InParanoid" id="A0A194XD85"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="133" mass="15163" checksum="FBF95D10ED1F18CF" modified="2016-10-05" version="1">MAAFVWSTNFKQNSPFADMLPSWGDFFRHPIASSKTFLEVVKLNADHNTAETMERRRRKVEDVQKRAAYRKAHGLDTEEGFGGWTAKSEKEVLGPGIPINDVAIAQEGEGEIVPEQQDVRHEKKPLKKWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDB6</accession>
    <name>A0A194XDB6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_707160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072102.1">
        <property type="nucleotide sequence ID" value="XM_018217581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDB6"/>
    <dbReference type="GeneID" id="28827307"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707160"/>
    <dbReference type="InParanoid" id="A0A194XDB6"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="230"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ17747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="397" mass="44006" checksum="3A0994A47F08787E" modified="2016-10-05" version="1">MSISETIKNIDAAAISFSSAAPGTVPESERQLLLAATKGLQNAIESPIDTVVSIALGAHRSAAIRTAMDLGLFTALIDVQEVGITSKGLGEKTGGDPVLITRLMRFLVAMGFAKELDIDLYISTPKTGYFAAGSPLQAPITHLASCARVIVRLADYFRETGYKNPTDAYDSAFQFAMGTDLQYWDWLKADQLQQEAFNATMALTRLHRGEPWFEFFPVESRFGSTPADAPLLVDIGGGLGHDLAAFQARFPNLPGKLILQDLPVAIDDIKELSPSIERVKHNFFDPQPVRGAKAYYLRQVLHDWPDKQSLEILTNIKEAMTEESVLLLNENFLPEKNVPLYNAEIDFSMLAMFSAAERTEKQWVDLLERAGLEAKKVWYPKERLDASATLFEAVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDN3</accession>
    <name>A0A194XDN3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_28812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072217.1">
        <property type="nucleotide sequence ID" value="XM_018206495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDN3"/>
    <dbReference type="GeneID" id="28816221"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_28812"/>
    <dbReference type="InParanoid" id="A0A194XDN3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="20163" checksum="3FBF661653D16CB5" modified="2016-10-05" version="1">MFHLRAKIFLTIYSRVLSSYSFQRFCHSSIVLSFSCSPWLHQVFCKPFLYFQARDFSSGKEASALREYLGTCAIIGQFSYNMTFRQISSKVLHLPFNFQPPDRYCREFELSQVAIGLMRDTYKGANVAQLQTHTISPLYTKWRLKDTTPIVLTLPPWESLSNLNSPAKLPRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDR9</accession>
    <name>A0A194XDR9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_684222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072654.1">
        <property type="nucleotide sequence ID" value="XM_018214838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDR9"/>
    <dbReference type="STRING" id="149040.A0A194XDR9"/>
    <dbReference type="GeneID" id="28824564"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684222"/>
    <dbReference type="InParanoid" id="A0A194XDR9"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="17783" checksum="25D2E7150AC92926" modified="2016-10-05" version="1">MSDKNTSTLQSYIDGATGAVQSAIGSLTGNTSQEGQGEAKKDKAQFENDASHATAKLGGFTASSSGAVTKDDPNRQEGSWNQTVGSAKEAIGGLVGSEDLKKAGAQQNAEGKGQEAQGQLSDFGSGIANRVGGAVQGGIAGITGDREAQLKAQEQHDVGKTMQRGAEADIQKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDX3</accession>
    <name>A0A194XDX3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_46596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072704.1">
        <property type="nucleotide sequence ID" value="XM_018207715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDX3"/>
    <dbReference type="GeneID" id="28817441"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_46596"/>
    <dbReference type="InParanoid" id="A0A194XDX3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="21655" checksum="B2CD134FA9F901AB" modified="2016-10-05" version="1">MQHQFAERMLLFFCSRWFNGITMVTVPLYIHTVCLLIEPLACLLLARPEERQDGRGMVDVTVTISISGPSGIGLVRNTWPTGITQPHQASSRIRYSLATLTLTLTLTLLPSGETASSSPPLQEDYSYSRVTCDVGSVTGDHEIAAAFGLFTSVQHLFRLFGFSPSDLNSAVRNHQPYQYLAFIFRSLQISLLCPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE28</accession>
    <name>A0A194XE28_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_684314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072764.1">
        <property type="nucleotide sequence ID" value="XM_018214851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE28"/>
    <dbReference type="STRING" id="149040.A0A194XE28"/>
    <dbReference type="GeneID" id="28824577"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684314"/>
    <dbReference type="InParanoid" id="A0A194XE28"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="166" mass="18291" checksum="C01C5B5ABC11F62B" modified="2016-10-05" version="1">MPSSVASSRSSSVEPSETMQIFVKNVSGDTFPMTVPQDLSIQNLTTLLSIRTSLPESDLRLVYAGKHLSSSSTLAEYNINKEATLHLAVPLRGGMPPKKIRCTYKDCREGAQRIIGDCGFCQGHFCGKHRLLEDHKCDGLEDCKKESHDRNAAQLNAERTQVIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF13</accession>
    <name>A0A194XF13_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_504571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073135.1">
        <property type="nucleotide sequence ID" value="XM_018207999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF13"/>
    <dbReference type="STRING" id="149040.A0A194XF13"/>
    <dbReference type="GeneID" id="28817725"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_504571"/>
    <dbReference type="InParanoid" id="A0A194XF13"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="52"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="396" mass="43969" checksum="9AD0108E863058E4" modified="2016-10-05" version="1">MVKIEPFDVEKWMDKYEVTPGVLNIAETCAASISIDDLVKLCEDPNVPKPLSTSTKLTYGPIRGSLALRERLASLYSARVSTPLPTDNILITPGAIAANFLVFYTLIGPSDHVICVHPTYQQLYDVPKSLGAEVSLWKLRKEKKYVPDLEDLKELVKDNTKMIIINNPNNPTGATIPKSVLQGLVKFARERDIIVLSDEVYRPLFHGISPVDEDFPPSLVSLGYAKTIITGSMSKAYSLAGIRLGWIASRDPEIIEAIATARDYTTISVSQLDDQVATYALSASVLHALLGRNIQLAKTNCALLERFIDQWSDVCSWVKPNGGTTALVRFEKDGKPVEDVQFCIDVIEQTKVMFLPASKCFGQDFKGYVRIGFVCETEVLKEALKQLSLYVRKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF54</accession>
    <name>A0A194XF54_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_643298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <strain evidence="12 13">CBS 120377</strain>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18901.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="623" mass="69555" checksum="5DF8FDA67A5E49A8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGE5</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
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            <end position="325"/>
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            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="325" mass="38150" checksum="3008C98DC001AB6A" modified="2016-10-05" version="1">MSYYGNEYDYEYARQSELEREYEYERALRADRKYYEQVHRNEVDNHRADMRRREEYAHKYTKAAWMEEQRDRVAKINPDCFYRGGDRFHNHLNDELEDAYRLGMAYNPEPSRRPRSSSPRRAAPARRNASATRSGYPPFNKTASRYDPASRDESGARGRYPPLYKPASRHDPASVHDTALPIAYYESSSESDSSSSSEEDLTKYNDDYSKGCKGTCYMPLNGASKPPEKPFIEARNHFKGRCTMKKNFTDEKQYTDYNQYWEDEAMAIATDPKNLNWGDALGDWKNEYTEYGEDWEKEATEKAMKSKGDEDWDKGTDVWDGEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHG2</accession>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="23703" checksum="5A579E9612EBAF87" modified="2016-10-05" version="1">MPNHLHQASKIDALGKAHLLTPNPKLDAALSNSKSNSLPDITITPLQGQYLAIQCKLQRAKTVLEIGTLGGYSTIWFASTGAHVTSIEINPKHRDVAVENTKGLDVEIVLGAALDVLPKLHAEGKKFDFVFIDAAWEEQFSYFEWATKLARVGGAIYVDNVVRELLEEEELGAEGSLVSKVGKMRGVQASLITTCSSHKGVEEEMMDGFMLAIVEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHS8</accession>
    <name>A0A194XHS8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_457921</name>
    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074039.1">
        <property type="nucleotide sequence ID" value="XM_018207661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHS8"/>
    <dbReference type="STRING" id="149040.A0A194XHS8"/>
    <dbReference type="GeneID" id="28817387"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_457921"/>
    <dbReference type="InParanoid" id="A0A194XHS8"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="255" mass="29614" checksum="5342D1D61CBE77D9" modified="2016-10-05" version="1">MKDSCNGFNMRVSMNSEYRFKIRSVTPDVRSREFFYASRLEPVVQGNETFQYFHRISGSTPQTKHIAVDVDIQNKAWRLLRLNGTDNQNEWLGYGSRHTNVTRLPKFFTLSAHIVQKGTMSLHKHQKHMHIPELNMSASNMKDFLHSVNQEPFLRIYDTRGLNDDQVTSLLDKKWSSKSDPRVIMRTAAFGHGRKTLGYSRRSLYMCVREHEGYSSDRFAEHAAPRHVVGIDDRNLVPLAIVWALRADKGDRFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIA4</accession>
    <name>A0A194XIA4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_579809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074248.1">
        <property type="nucleotide sequence ID" value="XM_018209029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIA4"/>
    <dbReference type="FunCoup" id="A0A194XIA4">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="GeneID" id="28818755"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579809"/>
    <dbReference type="InParanoid" id="A0A194XIA4"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="726" mass="82129" checksum="3EBF3754CD4D88B4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIB1</accession>
    <name>A0A194XIB1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_682702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074219.1">
        <property type="nucleotide sequence ID" value="XM_018214550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIB1"/>
    <dbReference type="FunCoup" id="A0A194XIB1">
        <property type="interactions" value="1334"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIB1"/>
    <dbReference type="GeneID" id="28824276"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682702"/>
    <dbReference type="InParanoid" id="A0A194XIB1"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ19864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="260" mass="28006" checksum="F62B4483B0916D71" modified="2016-10-05" version="1">MLPPNSVVYLGGVGDDKYAAILHDAVKTAGLRVEYRVDKTQPTGRCGVVITDHNRSMCTDLGAANHYDLDHLKSPEVWKLVEGATHYFVGGYHLTVCPPAIMALAEEAAKNDKAFVFSLSAPFIPQFFKDPLDATAPYWDYVIGNETEALSYAENHGLETKDIKEIAKALASLPKKNTKRERVAIITQGTEPTIVSVGGEDVQEFKVHAIDSKLINDTTGAGDAFAAGFTAGLVAGESLAQCIDQGQWLAKLSIQELGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIL6</accession>
    <name>A0A194XIL6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_470346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074430.1">
        <property type="nucleotide sequence ID" value="XM_018207755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIL6"/>
    <dbReference type="GeneID" id="28817481"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_470346"/>
    <dbReference type="InParanoid" id="A0A194XIL6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268290" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14056" checksum="E316F2C0692C3549" modified="2016-10-05" version="1">MYGFMLVACTSLRFPFLLSRLLFSVFPSRELSQVASMIPHLIHSPPYLSFFLQYNTLCPSTAFSLSSLLLQKMSNHLNLYEAPAPPICYPSYVYRLHHRTSFLIHTHLRIYPRPQRVSALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJD2</accession>
    <name>A0A194XJD2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_639833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074710.1">
        <property type="nucleotide sequence ID" value="XM_018211639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJD2"/>
    <dbReference type="GeneID" id="28821365"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639833"/>
    <dbReference type="InParanoid" id="A0A194XJD2"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="33399" checksum="31AFEAF304D7118E" modified="2016-10-05" version="1">MFSLQLQSRKRDREDDEETIASGFGEHRTKRHIAALPHRQSPKLARQVSPIFNYSSNYTSQPLPPTITPADSDSEDVAAAAEPRSFFSPYSSSPTTATLTQSGSPSPFLDVDGPQSSQSTQGSMLSTQMSDAPSYSDDFEMTDSFHLSPGPFHNDPSSSISGRIPTPIHSSFAPFIRSEKSTMHHDSDFADDEAMVDRFRRGRRLPSPISEGEMSPSIIIDGVHDMQVDVDNPHQEPDKETPTKKGHQRSKHSLRQWTGFGHDMHGNGGGTIKRSFSMGYRADCEKCRMKVPGHFSHIITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJL1</accession>
    <name>A0A194XJL1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_705796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074312.1">
        <property type="nucleotide sequence ID" value="XM_018217475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJL1"/>
    <dbReference type="GeneID" id="28827201"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705796"/>
    <dbReference type="InParanoid" id="A0A194XJL1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="40208" checksum="609F4170F2F9A5B3" modified="2016-10-05" version="1">MERQRTANYLTSVLLGADSLGTELVSREQLLRRRLRNHAIKAVVWPMTIIYNCLNTDILKGEERKETAWKLIREISAVMRGNLLDLTPDLLAQYVGNYIVDPPTELNPLISDVVQGIDNDIDMITGWTMKYGEQHNPPYLCPTNRKVLQQVKDIAEQVKEHWARLEEGHKEALDRETGKEYMDETTRRSSRHQSRRKYKARDMDGLIKSWIPPEQSAETATWSAPKDHKPATTSAATPERADEKSITEKSTETRTRQRTPFPEPKLAGTTRMKQNSSNHVDTKSTNHGAKEGKENDEEAKREASQSATQAAWKRLEEVKKEFETLDALRRSRAKADHQHWKDGDVVRNVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKF3</accession>
    <name>A0A194XKF3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crh-like protein</fullName>
            <ecNumber evidence="14">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_448606</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074976.1">
        <property type="nucleotide sequence ID" value="XM_018207599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKF3"/>
    <dbReference type="GeneID" id="28817325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_448606"/>
    <dbReference type="InParanoid" id="A0A194XKF3"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268344" description="Crh-like protein" evidence="18">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="326"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ20621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="41820" checksum="D373269478C104A4" modified="2016-10-05" version="1">MRSSTLSATSVVLAIAGLVSAQTFTDCNPLEKTCPADAGWGTTVTTDFTTGASSDWTLADGTTMSYGSNGAEFVITSTQAPTMSSTKYIMFGKVSVTTLASAGTGIVSSFILESDDLDEIDWEWLGADDTQVESNFFGKGNTTTYDRAIYHPVTDPIGTMTTYTIDWTADSIKWYIGSNLVRTLNYGDALALYGKNYPQTPMRVKMGSWVGCADAAAASNPATAGTCSWAGGPADFSKAPFTMSVKSVTIEDYGCGGDYTYTDMTGSWQSIKSSGTCGANNAQSGSSASGSATSATASVSSTASGTSSTTSGGVLLQTSSTVSTFTSSATGASNGSNGSKSNGTALASTMTTATSSGSSTKATTSSSGTTSSSPAQATTNAGESMKPKHKYGVLDYSVIVLGLGLGYLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKW8</accession>
    <name>A0A194XKW8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_705564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075131.1">
        <property type="nucleotide sequence ID" value="XM_018217459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKW8"/>
    <dbReference type="FunCoup" id="A0A194XKW8">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKW8"/>
    <dbReference type="GeneID" id="28827185"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705564"/>
    <dbReference type="InParanoid" id="A0A194XKW8"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="409" mass="45554" checksum="52EA9E58CA23A299" modified="2016-10-05" version="1">MLRQLRPQSALFKQSPSRLLATCMRAYSIEATSASTIKLQDIDPSKLSITKTKTPKELVPPNELVFGRTFTDHMLSLEWTAADGWLPARITPYQNLSLDPASCVFHYAFECFEGMKAYKDKDGRVRLFRPTKNMERMNKSSARIALPTFDGAAMIQLIAKFAAMEERFIPDTRGYSLYLRPTMIGTQRTLGVGPPGSALLYVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCILPQLEAAKRGFHQNLWLFGDEEYVTEVGTMNMFVAIKNKETGQNELITAPLDGTILEGVTRDSVLSLAREKLAPEGWIISERKYTMPELFEASNDGRLLEAFGAGTAAVVSPVRNISWKGNLVECGLRPDQEAGEIAQKMKDWIESRQYGDEEHEWSYVVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP55</accession>
    <name>A0A194XP55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_665095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076301.1">
        <property type="nucleotide sequence ID" value="XM_018212820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP55"/>
    <dbReference type="GeneID" id="28822546"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665095"/>
    <dbReference type="InParanoid" id="A0A194XP55"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08243">
        <property type="entry name" value="quinone_oxidoreductase_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="10"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="34427" checksum="E420BD91A1017793" modified="2016-10-05" version="1">MKAVVIHESGGPEVLKVQQWTKPVPSAGQVLIRVRAFGLNRSEMFTRQGHSPDVKFPRALGIEAVGEVEDAPGGEFKKGDVVGTCMGGMGRNFDGGYAEYTCVPTDQVQVVKAKISWELLGALPEMMQTVWGSLFESLQLKKEDTLLIRGGTTSVGLAAAALAKDMCASVAATTRNPKSEAMLKANGASEVFIDNGSIAEEVRKRHPEGFSKILELVGVTVLEDTLKCAKAQGIVCITGIVGGKWILENFNPHIIPTSVCLTSYGGFGAQRFKAMPLDQIAQRVVDGTLKIPIKTFTIDQIVEAHRTMDENTAGGKIVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP88</accession>
    <name>A0A194XP88_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine palmitoyltransferas-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_576259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076249.1">
        <property type="nucleotide sequence ID" value="XM_018208834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP88"/>
    <dbReference type="FunCoup" id="A0A194XP88">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP88"/>
    <dbReference type="GeneID" id="28818560"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576259"/>
    <dbReference type="InParanoid" id="A0A194XP88"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="253"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="679" mass="74934" checksum="AE10BEEBA9FDD47D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPN5</accession>
    <name>A0A194XPN5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_637592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076057.1">
        <property type="nucleotide sequence ID" value="XM_018211538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPN5"/>
    <dbReference type="STRING" id="149040.A0A194XPN5"/>
    <dbReference type="GeneID" id="28821264"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637592"/>
    <dbReference type="InParanoid" id="A0A194XPN5"/>
    <dbReference type="OrthoDB" id="5286354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF4">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="78"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="426" mass="46533" checksum="D8937A15E34A64F1" modified="2016-10-05" version="1">MSLNGGGGAEVVLADTTTAASPWANATAGQVLLNAGNNTVTFIDDWGWYFIDCIYVTPSPPPQPHKVSKKLVAPNPLPVTQALFETLLNKYGSGEIFSGQADPTGVTWLEQNVGKTPAIIGLDMIDYSPTRVEYGANSTAVEDAIEFDARGGMVAFQWHWNAPADLINNATVPWWDGIYTYGTTFNLTAALANPNGTDYGLLLHDVDAIAVELLRLQAANIPIIWRPLHEADGGWFWWGAWGPESCKTLYRLMFDRYTNYHGLHNLIWLWNSVTPSWYPGADVVDILGYDSYPAVGDHGPVDAQYQDLIALGLDEKMVTLPEVGNIPDPTLLKLYHADWSYFVTWDQDYITTDTYNNLTFKKAVYDDPTVLKLTDLGDWKGTATVSHTASIPSTTVTQTLSSSSSDMLSSTVASASKSISSSATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQC6</accession>
    <name>A0A194XQC6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_680540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076753.1">
        <property type="nucleotide sequence ID" value="XM_018214096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQC6"/>
    <dbReference type="STRING" id="149040.A0A194XQC6"/>
    <dbReference type="GeneID" id="28823822"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680540"/>
    <dbReference type="InParanoid" id="A0A194XQC6"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="583" mass="64591" checksum="7704DFE9C3033194" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR40</accession>
    <name>A0A194XR40_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_680867"/>
    <dbReference type="InParanoid" id="A0A194XR40"/>
    <dbReference type="OrthoDB" id="5353310at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="93" mass="10049" checksum="2CD97DE822D76076" modified="2016-10-05" version="1">MGGNPRAGRPHVVRPSPLQQVSHTRPLSSAPPTSGLVRDPLFWKRFSVAVHAAEVCDEESGKGSVKSGNTVEIKAAGYVLLFLGDIEQKTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRD0</accession>
    <name>A0A194XRD0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_309563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRD0"/>
    <dbReference type="GeneID" id="28816348"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_309563"/>
    <dbReference type="InParanoid" id="A0A194XRD0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17430" checksum="D61D5025A4091F4E" modified="2016-10-05" version="1">MVGVFGGLYIRRKGVVRPCQEGSVGHELNFLSLRQSRKRKNLSSARFSGRRDPLYVLLETVCAVLLSTVVQVQLGLCHITESYDRITYIRYCNWIKGVDWRAKLAFRLRTLNRRDDQLSFIVLCSYPTLRTSNFAGNGELLTSKTVDVSLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRN9</accession>
    <name>A0A194XRN9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_574248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077310.1">
        <property type="nucleotide sequence ID" value="XM_018208731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRN9"/>
    <dbReference type="STRING" id="149040.A0A194XRN9"/>
    <dbReference type="GeneID" id="28818457"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574248"/>
    <dbReference type="InParanoid" id="A0A194XRN9"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="420"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="486" mass="54019" checksum="4761E89FCA0F8A51" modified="2016-10-05" version="1">MGQDGLTKQQNGDAELMPAPEFNHSVGPSITSVASHDSPSTPPSYEEERQKNGETSIFDSWLAEYLLHCQNQVYRSSVPKLDRTMTDVYADELYNPSFQITSAAPTSTPSIAVSPQNDVFSQRLQAATSQHLSANTQTPLTIPSRERSPFRQGSPLAPSGNSFGNQSPNVRFGTATHMREQQKLENDARALQQQLERTSPEHTTPKTISPKDVDLVYHESEEDSKTPLFPPQQNQRPSYQKQHLMAHETTESDDNTSQRSYGSMATSRRESSSAYSNSSVPQQSSFNFAPPSVPGSVRVPQQYPFVPQARQQPSNLSNVTEEFPATLTSMESSSSEYAPESDIKKPEGATANSGGYSCTYHGCTLRFESPQKLQRHKREGHRNSASISGSNADEAGMTSRNSQAGPHKCERINPSTNKPCNTIFSRPYDLTRHEDTIHNARKQKVHCPICTEEKSFSRNDALTRHLRVVHPEHADLSKSRRRGARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRU6</accession>
    <name>A0A194XRU6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_574878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077273.1">
        <property type="nucleotide sequence ID" value="XM_018208771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRU6"/>
    <dbReference type="FunCoup" id="A0A194XRU6">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRU6"/>
    <dbReference type="GeneID" id="28818497"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574878"/>
    <dbReference type="InParanoid" id="A0A194XRU6"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="73"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="442" mass="48106" checksum="E9A2CA546BC64422" modified="2016-10-05" version="1">MTSERLIKPWKYGPQNTYVFKNARLIDTATGDILSNRTVKISHGIIQSVTLTENEYYLIESSNETTIDLKGKYLCPGLFDNHVHLWAVPGEATLGGMYQIDNEVSMSRQPFVVQQMLRRGFTSVRDCGGASLALKQAIEEGAIQGPRLFIAGHALSQTGGHGDSRGPHNHSECCGPIALGLVCDGVPACIKAAREELRTGADFIKIMSGGGVASPTDKLENVQFTGEEVRAITEVARNANTYVTAHAYTPRSIRHAVDNGVTGIEHGNFIDEETAKYMAERDVFLTPTLITYSVMASPDFPGFLPTESEAKNAQVLKFGLKSLQIASDAGVTLCFGTDLLGPLGIAQTQEFVLRAQVLNPKAILQSATINPARRAGLSDFLGQVKEGFAADLLILNENPLHDISILDKPEKHLLAVIKDGRVFHSRWSKLPQDALPEEPKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS24</accession>
    <name>A0A194XS24_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_636654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076882.1">
        <property type="nucleotide sequence ID" value="XM_018211494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS24"/>
    <dbReference type="GeneID" id="28821220"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636654"/>
    <dbReference type="InParanoid" id="A0A194XS24"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="526"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="581" mass="63907" checksum="3EDBCF7EEB3D1B34" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT74</accession>
    <name>A0A194XT74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_177109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077604.1">
        <property type="nucleotide sequence ID" value="XM_018205582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT74"/>
    <dbReference type="GeneID" id="28815308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_177109"/>
    <dbReference type="InParanoid" id="A0A194XT74"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF61">
        <property type="entry name" value="CAPSULE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="540"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="830" mass="94213" checksum="B4CAEB82313AFB85" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUH3</accession>
    <name>A0A194XUH3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_606181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077712.1">
        <property type="nucleotide sequence ID" value="XM_018210414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUH3"/>
    <dbReference type="STRING" id="149040.A0A194XUH3"/>
    <dbReference type="GeneID" id="28820140"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606181"/>
    <dbReference type="InParanoid" id="A0A194XUH3"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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            <end position="336"/>
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        </location>
    </feature>
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        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
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    </feature>
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            <end position="271"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ23357.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="624" mass="68578" checksum="31EC3A55E705B762" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUJ9</accession>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="ORF">LY89DRAFT_776101</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ23888.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="571" mass="63573" checksum="6AF4E00542536C1E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUX6</accession>
    <name>A0A194XUX6_MOLSC</name>
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        </submittedName>
    </protein>
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        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="21446" checksum="520669D639FEBABF" modified="2016-10-05" version="1">MVSFERPSPLWHVYFTFFFTVSRGNSTSQRFSRFNSPIFLHAVHKRRSTRIDRDTPYRHGHSLQYPWEKTTGWSHTFERPKYQIFRGSLDFWQASVLPMRQHAAGLKHRLCYTFPMLFRVVDLAVCILTFSLKNFPERSWNKLLSTRKQPCLIFLGSCILPDSYLTTTSRLLVLAPWQLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVG4</accession>
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        <lineage>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28827748"/>
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    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
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    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268637" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ24126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22283" checksum="5819A648CEF8F771" modified="2016-10-05" version="1">MRYTPLVYSLLTATLAVSALPEKQRPLQNNLGPAMPPPPSDSPSTSDPSGGDTVILSDVLGNDRSINIFAGFTRDFATISQRFEDSALNTTILAPVNSAIMGLPRKPWEDPKDYDELGANAYEGGDGEERAQRNLRRFVEQHCVAASPWKEGEKLKTLAGDEIWWESKDGVKMIQPGKIEVSSVASRVHNGEVWILKGVRNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1Y9</accession>
    <name>A0A132B1Y9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_769605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060676.1">
        <property type="nucleotide sequence ID" value="XM_018221825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1Y9"/>
    <dbReference type="STRING" id="149040.A0A132B1Y9"/>
    <dbReference type="GeneID" id="28831551"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769605"/>
    <dbReference type="InParanoid" id="A0A132B1Y9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ06321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="148" mass="15856" checksum="9E4C7FBA49ED6A2C" modified="2016-05-11" version="1">MAIVTSFRSFIRNLGATLGLAIAGTIINNNLRSKLSQVADISSSNLQWLLDNPSEVLAGSVTLPGTSTSVDLKDVFVAGYKVGFRTIFLVGAGLSGLAFFFAFALLPQIELSRPDEAKLKEGGKKFDEQLRQKKGGKADTKIQLHGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2J6</accession>
    <name>A0A132B2J6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_408953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060971.1">
        <property type="nucleotide sequence ID" value="XM_018207305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2J6"/>
    <dbReference type="GeneID" id="28817031"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_408953"/>
    <dbReference type="InParanoid" id="A0A132B2J6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="22309" checksum="86C33C6B12DE3E7C" modified="2016-05-11" version="1">MDTKASPMTTMEKCQDLLKLAEYLQTKSNDITESVCVVLEDLSRNAMKPWELLTVDDLVGFLGINNYVQDMTGIWKQLAPMVAPILAATAMWRRTLPEFRHYSSPTSKFETVTTGNVEFETILQEEITAILQGAYWARVEGVGSQGNIAWYVTDAAGRNLCIFEDEGVFRSLCIHRGFWLRPEFVTRYDLCIPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B358</accession>
    <name>A0A132B358_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_712463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061038.1">
        <property type="nucleotide sequence ID" value="XM_018217982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B358"/>
    <dbReference type="GeneID" id="28827708"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712463"/>
    <dbReference type="InParanoid" id="A0A132B358"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="36215" checksum="6EB6F1AEC3CE6346" modified="2016-05-11" version="1">MATYKPYSRINAFFPPAPTYTDSNLPSLQGKVHIVTGAASGVGYEVAKFIYLAGGTVYVAARSTARCEGAIEKIKAETASEKGKGKLDSLVVDLSDLRTIKGGVESFLKKEQRLDVLIHNAGIMSPPAGSKDKLGHDLEFGTNVLGPYLMTLLLEPILIKTATLPDTPKLSVRLVWVVSLVQGWAPVEAMRYEKDGTPVVLKGTMENYMQSKVGDVWLATDVANRLGKHGVMSVSLHPGVVRTELQRHWPLPVRMLIGAIMKPCVYAAYSELYAAFSSDVKPEQNGGHLMAWGRKADMPPYISAGFKSKSEGGTGGVQKFFEYCNREIKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B382</accession>
    <name>A0A132B382_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_743429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061146.1">
        <property type="nucleotide sequence ID" value="XM_018220953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B382"/>
    <dbReference type="GeneID" id="28830679"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743429"/>
    <dbReference type="InParanoid" id="A0A132B382"/>
    <dbReference type="OrthoDB" id="3565309at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28527" checksum="8B0B14E4E0028E49" modified="2016-05-11" version="1">MAIQSASSALGSLTEFTCFPELPAELRLMIWRLTFPKERKVGLLMMTFTSTKKRKSLHSKQLNEPLPVSLHINHESRIETLTHYQIFYRSDVGDIEPLAEPYDRPLCVNTTLDTLVLPVDLALLGCESEYYKSEYTAWMTYLDNNLDGGLKSVRYLRIAGHIGFRGEEALKAIECFQGLQVLTVSLDMAYAAAASLAIKQLMIDRRRKQLEEWYKVCQEKMIDFHIPRIILEVDPGRDGGQYRLRFMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5B2</accession>
    <name>A0A132B5B2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_631163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061947.1">
        <property type="nucleotide sequence ID" value="XM_018211267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5B2"/>
    <dbReference type="FunCoup" id="A0A132B5B2">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B5B2"/>
    <dbReference type="GeneID" id="28820993"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_631163"/>
    <dbReference type="InParanoid" id="A0A132B5B2"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF51">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ07592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="26317" checksum="2C81FBD37140B50D" modified="2016-05-11" version="1">MDAQGRHFSVSHFLRQNQNRIFENNRAWVEAKLEEDPTFFERLSAGQEPDYLYIGCSDSRVPANEIMGLEAGEVFVHRNIANLVPNTDLNVMSVIEYAVLHLKVKHIIVCGHYNCGGVQAALSHSDMGLLNPWLRNIRDVYRLNEKELDEIEDAEQKWKRLVELNVLEQCKNVIKTAAVQQSYTKNEFPIVHGWVFDLRDGLLKDLKLDFEEALKDIKKIYDLEVGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5I7</accession>
    <name>A0A132B5I7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_355471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061868.1">
        <property type="nucleotide sequence ID" value="XM_018206960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5I7"/>
    <dbReference type="GeneID" id="28816686"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_355471"/>
    <dbReference type="InParanoid" id="A0A132B5I7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287877" evidence="1">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="169" mass="20118" checksum="1D682955A233452C" modified="2016-05-11" version="1">MSIFLFFFWDCLSCTELGRAGMLMKGRMVDTFFYERKHKRLDGWTDRWREDSLRERRDVKHTFCAHLFGLQVFLFFPLVEGMMDENHVDLCADEMIRASDGERWREQYNTNNHHLTSPLFETKSSSRRDIISAYLPTQSPSYFPFPIYPNDAQQSINQSNSFFPSFLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5T0</accession>
    <name>A0A132B5T0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_789455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062123.1">
        <property type="nucleotide sequence ID" value="XM_018223256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5T0"/>
    <dbReference type="STRING" id="149040.A0A132B5T0"/>
    <dbReference type="GeneID" id="28832982"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789455"/>
    <dbReference type="InParanoid" id="A0A132B5T0"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF4">
        <property type="entry name" value="FUNGAL N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="442" mass="49292" checksum="36701D0950BB9778" modified="2016-05-11" version="1">MAELAAIASIVGVAAKGAQLSMVLFEFGSTIGSARSEVNQIATEISQFCGVLKQLHSTLTRAQARRYSISAIATTQDILKRCQEIFKEIEDIVHPLQKSTGKSNEQLSVDVIARVKWTFKRSKVQVLQKTLESSKNTLQLMLLVLDLARKTVSPRASTIDKQLEDQQEQVIIQGLIAAQRCAVDQLETLENEAEEQDSHQRDPIPKIKSPDALDEISATEDREQVMGDESEDERDVKKQRDSVWVNDLIFSNSPLSPGFRRNTWDDAVSSPSIESQAAHLFQVWTDQAPEEAETSGQNDEKSSGSGVATDISEEKSGNKWKPLPKPPAQPHILAQPPETLYVVVLYDYEDDDTPNLAIREGDIIQVITKLESGWWDGVLHGVRGWFPSNYTRPIGNGSIFSDLIEELDEAEYEDEDENEDNFGVDNVDGDELDDVFRSRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5V1</accession>
    <name>A0A132B5V1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061724.1">
        <property type="nucleotide sequence ID" value="XM_018216416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5V1"/>
    <dbReference type="STRING" id="149040.A0A132B5V1"/>
    <dbReference type="GeneID" id="28826142"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691822"/>
    <dbReference type="InParanoid" id="A0A132B5V1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="20090" checksum="99AE966187FB8222" modified="2016-05-11" version="1">MEEHALVPAFGEVIDVGDGGRLELAAQRPGFTPRLSSFSINANDSTTSLLSSSRKPNGSGLKQSVTASEDPDPLEVIEKLLNLPHNGRENTDGESSVGNVTTISSSSMESTEPGEFVCALRLLRSQRPRPDSSSSASPPRPADHGQIKKSKGKISEDLRKKAQKKAQQKAQRMAPTKSRVETESILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B621</accession>
    <name>A0A132B621_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_601002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062058.1">
        <property type="nucleotide sequence ID" value="XM_018210176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B621"/>
    <dbReference type="GeneID" id="28819902"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601002"/>
    <dbReference type="InParanoid" id="A0A132B621"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="478" mass="52557" checksum="48581476DDB3FA92" modified="2016-05-11" version="1">MDGIFSKQVDCLVKVGLRDRVVLPTTSEFAARIDSYFNNSAKLTPACIFMPQKTAEVVTAIKALVNGGQKFAIRSGGSNFWPSNNIDDGVTMDLKYLNTTEYDPKSETVMIGAGVCAGEIYERLAKYERAVGAAREASVGIAGLALTGGITLFTGRYGFACDQVVAYEVVLADGRVVIADATGGHKDLFKALKGGGNNFGIVTHFTMRTFPCSTIWGGGAILPKEIFPKAAEAIVDFVNRVSDDPDTNLICMLCKITPKPVTIVAALYANMAGVERPPILDKWLAFPEVWKSYKKDSILGLLDTTEQAKNYYGNWFTLCFKNDATIIMKAAELHDALVEQLQDHIKDGDFKTQCVFQPLPLAFIQTSSKMGGNVMGLEQHDSNGIIWGFHVMVRTPELEAWALPRERRVYEGVREFAQSIDGLLNWTTANYAHPTQEVFQNYGKKNVEIIKEVAARYDPDGVFQYLCPGGFKISSVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B688</accession>
    <name>A0A132B688_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_344061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062275.1">
        <property type="nucleotide sequence ID" value="XM_018206871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B688"/>
    <dbReference type="STRING" id="149040.A0A132B688"/>
    <dbReference type="GeneID" id="28816597"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_344061"/>
    <dbReference type="InParanoid" id="A0A132B688"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="836" mass="95643" checksum="80FD665640E58BBF" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6D4</accession>
    <name>A0A132B6D4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_630407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062321.1">
        <property type="nucleotide sequence ID" value="XM_018211240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6D4"/>
    <dbReference type="GeneID" id="28820966"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630407"/>
    <dbReference type="InParanoid" id="A0A132B6D4"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="102"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="36594" checksum="45B555D9384073DA" modified="2016-05-11" version="1">MSNTHTDVLLAGAFAAFTVDLLVYPLDTLKTRFQSPDYKKIYYDASKNAVNRKLLFRGLYQGVGSVILITIPSSGAFFTTYEAVKSGLSKANPTYGGSPLIPQPFIHSAASATAELVSCFILTPAEVLKQNAQMIRRPAESSSKTSTAFQPSVTIQALKQFKHPSQLWRGYTALAARNLPFTAMQFPMFEHLKESIKQYRQKSGTYTGSLMETALMTAVSAGSAGSLAAVITTPVDVVKTRIMLSATGEASEAEAKKEIARARKEGHSIEKLANRKGVTRKSGLTVAKEVLAESGVKGLFRGGTLRAAWTALGSGLYLGVYDSGRVWLGGQHKHDDLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Z0</accession>
    <name>A0A132B6Z0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_677066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062531.1">
        <property type="nucleotide sequence ID" value="XM_018213651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Z0"/>
    <dbReference type="GeneID" id="28823377"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677066"/>
    <dbReference type="InParanoid" id="A0A132B6Z0"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="401" mass="45962" checksum="25060E5989C1B041" modified="2016-05-11" version="1">MPPEGCAGDQPLHKLFCDEVEEFLASNPQPQDSYQTTYKLGLVLHEMNTSAEVELELTWVRTELDIDHDTGYWSLLRNVSGWLKSAEAAIHARHDRKIEIWSSTDKENLASNDNVRLLASNGMKFNMQDEADGGNFEGPIVVMAVSKYSDRVSEYRDFAAADLRILLSCFLQDTFFYEIDDETDFTTTSKYILFDQPEWIQGVAIWNSGTPNMFHVNLQLVMINRNHPKVERYDHKSAISEHMDIPLLFLEYPKKPGDLRDYTNKTAYREDGQAVTLQQIEALSAYCQFVLSRALEPPEDWTWEPEDKKAVLDVWCSAEKFGKYFEIFKKGKLAEDNEASAEWADALPPPGMRSAGIVVEENLESPLPKERDDDTPEQRRRRVLKYAESRAKVAMSDPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B919</accession>
    <name>A0A132B919_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetylserotonin methytransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_690861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063253.1">
        <property type="nucleotide sequence ID" value="XM_018216186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B919"/>
    <dbReference type="STRING" id="149040.A0A132B919"/>
    <dbReference type="GeneID" id="28825912"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690861"/>
    <dbReference type="InParanoid" id="A0A132B919"/>
    <dbReference type="OrthoDB" id="5383338at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62869" checksum="7EF6F4918BC2F326" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAP0</accession>
    <name>A0A132BAP0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_599204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063082.1">
        <property type="nucleotide sequence ID" value="XM_018210079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAP0"/>
    <dbReference type="GeneID" id="28819805"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599204"/>
    <dbReference type="InParanoid" id="A0A132BAP0"/>
    <dbReference type="OrthoDB" id="3523814at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288053" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="104" mass="11610" checksum="BD1C7680F9AD7219" modified="2016-05-11" version="1" fragment="single">LPLDSLYVAILIALAQRSRATASSHTPARPLKVSLFVSEHTKDTSTNVQSHASSPPAWITSLKQYTATIADAYLQKFDDPYHFHASTLHIYQTLYHINILATIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB84</accession>
    <name>A0A132BB84_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HK97 family phage prohead protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_658179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063459.1">
        <property type="nucleotide sequence ID" value="XM_018212465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB84"/>
    <dbReference type="GeneID" id="28822191"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658179"/>
    <dbReference type="InParanoid" id="A0A132BB84"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="537" mass="59207" checksum="1C44781C1B05294F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBL6</accession>
    <name>A0A132BBL6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_740839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064123.1">
        <property type="nucleotide sequence ID" value="XM_018220644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBL6"/>
    <dbReference type="GeneID" id="28830370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740839"/>
    <dbReference type="InParanoid" id="A0A132BBL6"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18221" checksum="F87B2389375FFC55" modified="2016-05-11" version="1">MLRRKTNAAIAVIIRIPYVKTLVDNASDFLFSSTDVVIWSAIEPGLAITAANMATLRPLFQAFLSRTKLWGSTTARGNSSGYRHSKSRSRGFSNGGRKGYIRSGSKGNITTDGDMEGDEVGLKDMVSPTENPDEKVRRRSRRVRFRYHCRYRGMGRGSRDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBQ5</accession>
    <name>A0A132BBQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_657341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064166.1">
        <property type="nucleotide sequence ID" value="XM_018212426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBQ5"/>
    <dbReference type="STRING" id="149040.A0A132BBQ5"/>
    <dbReference type="GeneID" id="28822152"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657341"/>
    <dbReference type="InParanoid" id="A0A132BBQ5"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="52788" checksum="0F016916FC42AA9D" modified="2016-05-11" version="1">MDQLPDIDHWLVTPDNPPRNQIGLDHERCVALYNYLLQYSFAASNKEFGDRHKISWFEKHGDKAERAREHLDPSLIKFLENAYDPRDADFAILFYWVRGINDPTYLWTNWEDFSNLGEEHGRMTLFYTNCALLGCHQDGLCYDQQLHKAVVFISIHDQDFASGDENSHLWYPLETILRNWITVLRMGKITAEPDDVKVENDRYRPWTCHRYSTKQVEDTVTAFNRLADAIESRIPSTRKGMPPVRNFSHELMDATLIPNPSFARSFLSAIGVPAFKYIAPGLLIPTEEDFAKNQILAATENYDKLSTIPAVLLFKVEPESASQEQQGLNAENKDEHTRKPAGLYTEETQVWNDDIAEEGFRLILPYSIAEHGFARKRTGHLIEQNGNGGFEDLYQHGFKPFGGDWSRAQRLVRLFDNWTGMVEKGLWEVGPDGVMGGIEKFKEADSEEGWRNYWIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC84</accession>
    <name>A0A132BC84_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_274367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063974.1">
        <property type="nucleotide sequence ID" value="XM_018206394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC84"/>
    <dbReference type="GeneID" id="28816120"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_274367"/>
    <dbReference type="InParanoid" id="A0A132BC84"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF3">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288113" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="481" mass="50221" checksum="D960B2C94D00AE07" modified="2016-05-11" version="1">MFLKCRKVVWALLIGTVSAGTVTYSIPASVPTSATPLDVAPVGISFEFFTFPSYFLNVSATNQCLKNFETLTGVWPPIRIGGTTQDRATYDPSTSAYVVYSVAAPTDAPASLTFGQSFMSLASTYAGNVVLGLNRAHDNISNTIAAAKVATAKMSNLRAIELGNEPEYYLTDDQPIATESGTWTPAIDAASQDNWDILVGSALSKTNIIQAGNSNSAPPTWGAAELIATENDTVQSYVYDYAHHNYPGGTISSLMSHSDISSNLAIFNDDIAAAATTGKDYVLGETNSVSGGGASTVSPLFGAALWTLDYSVLASSLGIKRTYFHHGTIGACYYCFWGRYDMGAPYYGAYVATAFMAGAAAVVELDDGSTDYAAYVVFDGAGSPLRVLLVNSDYYSSGTRGSETFVLGGLGGAASVKSKRLTAASANSRVDQGGNPTFGGQTFANETCVIGGTETFESTAVSGGTGSFVVGASEALLVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCE4</accession>
    <name>A0A132BCE4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_555967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063682.1">
        <property type="nucleotide sequence ID" value="XM_018208366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCE4"/>
    <dbReference type="STRING" id="149040.A0A132BCE4"/>
    <dbReference type="GeneID" id="28818092"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_555967"/>
    <dbReference type="InParanoid" id="A0A132BCE4"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13848" checksum="59CFD7ABEF0BFE4D" modified="2016-05-11" version="1" fragment="single">WRPKVHAELLVLDHFWTQSLEFLDGDRFIACSKPACYCCYHYIAAHPGRFEVPPSHNNCWIRWRAPDIFDSTRQDLLKTREDILNAMAKKIRIEVLEQIRERRGPRANRPDSLTEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE17</accession>
    <name>A0A132BE17_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_787729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064439.1">
        <property type="nucleotide sequence ID" value="XM_018223099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE17"/>
    <dbReference type="GeneID" id="28832825"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787729"/>
    <dbReference type="InParanoid" id="A0A132BE17"/>
    <dbReference type="OrthoDB" id="3800761at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="434" mass="48949" checksum="E9DC6E81D88840A5" modified="2016-05-11" version="1">MPSSPPPSESTSTPLPPDFTSPRVAFASTPIPECPDSNHESLSRGEHSLSAQSSWEDRSMEDERWSENGRSSASFESGMDCSFFSVGAKHAIWNNCGGEDKCWICDDSENPRLLKYHEIIHRDHSAFEDYMKNKHLIDFNDLRDARNGILLCAVCQPLYSNPSYTTILSFPTDLLYFYNHEILDRARRRQLSIETGIVPPRCCVTAKMYQKHQLSPGVITKGSWGSYTRLNVYPQNQPITRLASLPVEIQKAWGGSPMAMIHHSNWGMNGWLTFGAIPRDVRIMFRKLQDIYSKSLTANDGEEKFLVRNGDDFVEDVSPNDLTDFDSNSGMGEERKFKDKHSDSSEDDEERPNRDHLLQDWLARIEYPPADLNNNGLRGRLPPNLLTTLPSLAPPSLSPSPHDRFVDPSLPLSPVLKTPMPISAGTKRKRRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BF18</accession>
    <name>A0A132BF18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064819.1">
        <property type="nucleotide sequence ID" value="XM_018215954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BF18"/>
    <dbReference type="GeneID" id="28825680"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689700"/>
    <dbReference type="InParanoid" id="A0A132BF18"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="90"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="373" mass="40956" checksum="35E8A9A4D126AB86" modified="2016-05-11" version="1">MDAVLSSTTALVSFSILTTLTAITVSRLIFRGDEVKVIKSPAATLLPKLSLTEIAALPYPPDALPGGRDVESPYGTVRVFEWGPEHGRKVLLVHGITTPGLALGAVAHGLVERGCRVMIFDAWGRGYSDAPADLVYDERLYATQILLAVTSSPLSWTGGLNGGFSVIGYSLGGGISICFTSYFQNMVKSLVLLTPTSLIRDSRLGVQKYFPILFSIIPEPILEVLLKKRLQRPMFPKENRESVATAEVTPNEAILKEPPPSLKYPDVTVFAATQWNIQTHPGFIRSFTSVARFGPAAGQHAAWRRLLQKKRKILIIVASHDPIIVTEELKPDVEEVVRDSGTDIVWREIDGAHDIPTTDPDKIVRDICAFWEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRQ0</accession>
    <name>A0A194WRQ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_739672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065028.1">
        <property type="nucleotide sequence ID" value="XM_018220489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRQ0"/>
    <dbReference type="GeneID" id="28830215"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739672"/>
    <dbReference type="InParanoid" id="A0A194WRQ0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="33362" checksum="C06AD7E93187809F" modified="2016-10-05" version="1">MDNQTDLTHDDNIGREQISSTSLPHDWRSHPFIFLTQACHAGDFETVRYILTEIREGPDLDDIKNSFSTDLLWACTTGYPDILTCLLEHGAPITNCATYAASIEDADTAIRIYDILFEHGLNLADYPGIVQYLENEKVLEYLLSNGADPNGLDDYHNVPLNICDTESTIKLLVDYGTDLSLAPLLHDFVCFPNHTYSEESCEFLLSVGVDINAPAVYAGHAPPGSKLYQDAAGRLVDGGTALHFLVRGFGRKGRPDVDPIPRMKWLLEHGANVDIKDDCGLTPLDYATEPAMIELLKSYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSA3</accession>
    <name>A0A194WSA3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_558278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065203.1">
        <property type="nucleotide sequence ID" value="XM_018208412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSA3"/>
    <dbReference type="GeneID" id="28818138"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_558278"/>
    <dbReference type="InParanoid" id="A0A194WSA3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="14394" checksum="68C0EBB6E201C5EB" modified="2016-10-05" version="1" fragment="single">YMLEHGWNPSSYGHNDAHPLTIAAQSFPPSTLKFLLDHGVSPRGTQAMHAAVTWAAIDGEITGGVVTDPTRYEVLDLLLQYGADVNEMEVDPKARRPPRRRDGFTGTPLHRAIGQESLEMVKYLLENGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSR5</accession>
    <name>A0A194WSR5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_689317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065017.1">
        <property type="nucleotide sequence ID" value="XM_018215884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSR5"/>
    <dbReference type="FunCoup" id="A0A194WSR5">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WSR5"/>
    <dbReference type="GeneID" id="28825610"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689317"/>
    <dbReference type="InParanoid" id="A0A194WSR5"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="290"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="623"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ10662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="862" mass="97095" checksum="5647DDC16D77806C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTU0</accession>
    <name>A0A194WTU0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_758860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065459.1">
        <property type="nucleotide sequence ID" value="XM_018221445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTU0"/>
    <dbReference type="GeneID" id="28831171"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758860"/>
    <dbReference type="InParanoid" id="A0A194WTU0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267518" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="109" mass="11636" checksum="1B348F6E6FB1B850" modified="2016-10-05" version="1">MNKLITLLMISLVLLSLSTGFPSIVNNEAIAARSKRCMCKETGTFCSSRKGKTNGNCPDNTLLSCEHGEKATVYWSCTNPFNSTDSVCVEGADPSGKDDECAPIILNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUS1</accession>
    <name>A0A194WUS1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_595077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065717.1">
        <property type="nucleotide sequence ID" value="XM_018209839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUS1"/>
    <dbReference type="STRING" id="149040.A0A194WUS1"/>
    <dbReference type="GeneID" id="28819565"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595077"/>
    <dbReference type="InParanoid" id="A0A194WUS1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="152" mass="16916" checksum="2DB12A852509ACA7" modified="2016-10-05" version="1">MAAPGRAPAPAPTSRSREAPQGDEEAAAELKLGEFQDVDALTHSEAMLVINALVAKRRMDKKNINETEMLMKTTDYLDHFARFKRKENVEAVERLLSAHKELAKFERAQLGSLCCDTAEEAKTLIPSLQDKIGDEELQDLLDEITKLMGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV09</accession>
    <name>A0A194WV09_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_212807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066155.1">
        <property type="nucleotide sequence ID" value="XM_018205882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV09"/>
    <dbReference type="GeneID" id="28815608"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_212807"/>
    <dbReference type="InParanoid" id="A0A194WV09"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="136" mass="14278" checksum="832C48BB06411F57" modified="2016-10-05" version="1">MSVPDETPAPAKPGSSRSHHLPYGRARAGGGAAMGHGMNALVAVGSKDRLKLRQRSNYLLTVVVGVQCGAGSQASRLRVASASGLLLQRENHNVTMLACASISLAFPKFLLLLLAAALPSLTLPYLTDLPLLTFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW26</accession>
    <name>A0A194WW26_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_234468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066142.1">
        <property type="nucleotide sequence ID" value="XM_018206052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW26"/>
    <dbReference type="GeneID" id="28815778"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_234468"/>
    <dbReference type="InParanoid" id="A0A194WW26"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="60" mass="6689" checksum="16B6FEAEB420936B" modified="2016-10-05" version="1">MRGAGKHCCSCNTFYSHRIVCSPLNQPWSKCSLPSNRSGQRRKTCRPLHETIPASGKTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWJ6</accession>
    <name>A0A194WWJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_673310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066675.1">
        <property type="nucleotide sequence ID" value="XM_018213354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWJ6"/>
    <dbReference type="GeneID" id="28823080"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673310"/>
    <dbReference type="InParanoid" id="A0A194WWJ6"/>
    <dbReference type="OrthoDB" id="10326165at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="19996" checksum="37FC0AD400D1F8E6" modified="2016-10-05" version="1">MSIISTTTRSSTPCNVSIFTVSSFYSATETIFPCLHVRMLHEQCGHISTLTIHESPCPRPYYGWVLAPLGSSTLPREPPRIRCEGMEFHVAIEKDKCKNCKAVLALAAGKTMCEKFGWGRATKRKDPVVRRDRERQLDVGEIVKRRAEWKREVDAWKARRFERMQEEARAKGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWV5</accession>
    <name>A0A194WWV5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066813.1">
        <property type="nucleotide sequence ID" value="XM_018215647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWV5"/>
    <dbReference type="GeneID" id="28825373"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688147"/>
    <dbReference type="InParanoid" id="A0A194WWV5"/>
    <dbReference type="OrthoDB" id="10371592at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="79" mass="8594" checksum="5B1701CFACF78F50" modified="2016-10-05" version="1">MFGEEDSALWGPPQALLEKKRGGGRSMRLAFLCLILWMASSASFGGLIALWGLNSVNMNRESCGDSALAMTFWDPLIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWX1</accession>
    <name>A0A194WWX1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 8">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_592953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 8"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="GlxI_Zn"/>
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        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
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        <property type="entry name" value="Glyoxalase_1"/>
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        <property type="entry name" value="Glyoxalase_1_CS"/>
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    <dbReference type="InterPro" id="IPR037523">
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        <property type="entry name" value="glyox_I"/>
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        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
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    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
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    </dbReference>
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        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
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            <begin position="137"/>
            <end position="283"/>
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        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU361179"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="33440" checksum="202848B401B8D89D" modified="2016-10-05" version="1">MKMIKKIEQPDAKFDLYFMGYDSPKAVSHGNDFSDREGLIELTHNYGTENDPNYKVTTGNAEPHKGFGHTCISVDNIQAACKRIEDAGYKFQKKLTDGRMRHIAFALDPDGYWVEIISQNPIDKTENITTTDLATYRMNHTMIRVKDHEKSLKFYQDVFGMTLMRTSENKDAKFNLYFLGYPGSKGVSTESVNGVNPTADREGLLELTWNYGTESDANFKYHNGNDEPQGFGHICVSVDDLDAACKRFEDQGVNWKKRLTDGRMKNVAFVLDPDNYWIEVIQNEKLKNRANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X007</accession>
    <name>A0A194X007_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">WD repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_591161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018209638.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_591161"/>
    <dbReference type="InParanoid" id="A0A194X007"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="8"/>
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="757"/>
            <end position="795"/>
        </location>
    </feature>
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            <end position="39"/>
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        <location>
            <begin position="807"/>
            <end position="940"/>
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    </feature>
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        <location>
            <begin position="1023"/>
            <end position="1060"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="931"/>
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            <begin position="1023"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114784" checksum="AFDE9EEB9E38E607" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0T5</accession>
    <name>A0A194X0T5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_698941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068166.1">
        <property type="nucleotide sequence ID" value="XM_018217015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0T5"/>
    <dbReference type="GeneID" id="28826741"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698941"/>
    <dbReference type="InParanoid" id="A0A194X0T5"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ13811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="421" mass="46100" checksum="A1E5FF05CA1F1953" modified="2016-10-05" version="1">MVQASYRVEQWTEYGIGMCIFTLRFFARWKVVGIANFAWDDFFAFVAMCLWTVGSATVQIINDYGSFVGLNEQTAGALSDETAASYEVGSKALFVAWISYVTLIWSLKASLLFFYSRLTMAVLSAIAYVAVLLTLFGHCTPIQKNWQIKPYAGVANYIVVAALNLLTDAGILAIPLPLIWKVKIPLRRKLIIGLLLSSGLFVITAALLPCIFTLASVSQIGNSTIWGIRETFVSLIAVSAPVIKPLFNKSRWIGSSNDKNTGSSGFKRFGRNQSVRELSAAHSATKIGNDYDLETGRSGHRKGDMSPLSDFELKDLSRHGSEEYIIENNNSKSVPLEINVTTVYALADENGNETPVSPKTVNAEKSVEDIQNGASPFRRGPVPRREGWKPRGENITEISVGERPEGSVSKASRMLGMGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28825084"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686758"/>
    <dbReference type="InParanoid" id="A0A194X254"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="125" mass="14023" checksum="C78E36996A971AA5" modified="2016-10-05" version="1">MKYGYNPETYAGLPTVSQNAAAFTQKDAEKALNDCGKVFFNHFLQKTYGLVLLYSHFQLTPEEFMVEYRGIATAWPINTKLPVGAGIHPTTWAITDGALEPYEFEFILGSEKFGDDLDDINLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2F5</accession>
    <name>A0A194X2F5_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_538783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208135.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194X2F5"/>
    <dbReference type="GeneID" id="28817861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_538783"/>
    <dbReference type="InParanoid" id="A0A194X2F5"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="342"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="15"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="126"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="795"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="795" mass="87553" checksum="4FCEBE67260A9320" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3C2</accession>
    <name>A0A194X3C2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3C2"/>
    <dbReference type="GeneID" id="28829865"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736557"/>
    <dbReference type="InParanoid" id="A0A194X3C2"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140361">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="55685" checksum="CFD32323B099BCEE" modified="2016-10-05" version="1">MESSPLILAHDHARAASVATQSSDTTVAINEHALAAGEFAKAASGTGSAEALRTLRLLEQHHQRLSELLRYPVENPPNTTSTEGEVQAVSQKPLSTSAAVAELRASKSDLGPRSSSPLRNPPSLQHPRRLPPRDLSSSIASNLASARGIRANYTRQPLSPSVSTQQAPGSLEALPRKRSKVPASIPEHSQPSWVPPKQNATQIVEPQVADPSTVVAANNDEGFSRFYNTFENILSKLSAPLAFAGLPLITEEGPEPAAPEPTKAPRRRPQSKERIDAEPDLAKYISRAALRASARDGHSGNDSFYVVPTSGHTASYAHILSFDQKEKRRLAASMHSENADLFPDPEEDDFVDARETPMPISPTTSRRGTSGRKMNDRALENKVEELDIENKSLKDCIDKLSKRLHAFESSAQQSTMALQESMRFARTMSPARDQGSRGGDEALKRRVLELEEHVALGGKEIERLGRENGKLREVVERYRERWEKLKAGAKTRRDGGGSSKEPPTKDSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3E9</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28821831"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650434"/>
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    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ14554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="540" mass="61590" checksum="E3081CCF9584171F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3S3</accession>
    <name>A0A194X3S3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_589033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069044.1">
        <property type="nucleotide sequence ID" value="XM_018209509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3S3"/>
    <dbReference type="STRING" id="149040.A0A194X3S3"/>
    <dbReference type="GeneID" id="28819235"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589033"/>
    <dbReference type="InParanoid" id="A0A194X3S3"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="2">
        <location>
            <begin position="61"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="437" mass="48404" checksum="F8A039F60F9616CD" modified="2016-10-05" version="1">MKRKAESPELSSKKAPKLDDYCNTQPNRDDHGNIVWPAQARQIVAAQEFLRECASSQKPTLIVPDKDADGLSAGVIVHRTLMKMGLDSKYLDVHLVQKGSNIHEDNERKAMQEKKPSYVIVLDQGSRGGPPVIDNPDVRSIIIDHHLSDEFPKDAQVVSACHCPPVATTSLLIYEICKELDPDIASECGYLCAIGTHGDLGNTLKWLPPFPDMAETFKRHTKKLINDCVSFINAPRRTGTYDVITAWTALLEAKDPKQIMNNRRLAEAREEINIEVEKQTHTPPKFSKDGKIAVLKINSKAQVHPVIATRWASHLKSKALEIVMVANYGYLPGKVNFSCRIARCARGRDPPINIIESLKAVADLDTTDLVQRLGESFARGHKEASGGIVNTAEFEELCGLMKVGEKPDKVEGEGVGAKKKVETSPQKNTLNNYFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4U0</accession>
    <name>A0A194X4U0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline phytoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_106099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069545.1">
        <property type="nucleotide sequence ID" value="XM_018205039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4U0"/>
    <dbReference type="STRING" id="149040.A0A194X4U0"/>
    <dbReference type="GeneID" id="28814765"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_106099"/>
    <dbReference type="InParanoid" id="A0A194X4U0"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26426" checksum="031409C7A16473E3" modified="2016-10-05" version="1">MISLSFCEEDYAVTQYIAEFINTLSNIAYIYCALYYPSGTKSRRKLDSMSMALIMVGITSTLYHATLRHSMMLGDDFSMWLIVACILRPLYCRGQSPAVASFITAVIALACCVMTIIYLHSGSILIHTGFFAFLLQLIWPRTLFLIYGAGNRSQMEKKKLLRRFLKAAVTLIVAFAAWDIDLERCPQLREIRKSIGLPCAWALELHGWWHVLTAVGAAEYITLVRILCDQSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5Y0</accession>
    <name>A0A194X5Y0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cip1-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_619624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069940.1">
        <property type="nucleotide sequence ID" value="XM_018210886.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5Y0"/>
    <dbReference type="GeneID" id="28820612"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_619624"/>
    <dbReference type="InParanoid" id="A0A194X5Y0"/>
    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267929" description="Cip1-like core domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Cip1-like core" evidence="2">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="25186" checksum="4E0713BC4818E49B" modified="2016-10-05" version="1" fragment="single">MFLQTALLVALLPLSLAQVTNDFESGWDQTAWPIYAPSCNQGGKVTLDTTTAHSGKNSIRVDGAGGFCGHIFFGTTKVPSGDVYVRTYLKASKALTDSHVSFITMPDSAQGSDKHLRIGGQSKILMYNRESDDATLPSLSPQGIASSTVLPTGSWHCFEYHLGTDGTIETWLDGTAIAGLTSKAGVANPNADQWQKSTIKPKITGVYFGWESYGGDVNTFWYDDVAVSSTRVGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X643</accession>
    <name>A0A194X643_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_685604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070008.1">
        <property type="nucleotide sequence ID" value="XM_018215115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X643"/>
    <dbReference type="FunCoup" id="A0A194X643">
        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X643"/>
    <dbReference type="GeneID" id="28824841"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685604"/>
    <dbReference type="InParanoid" id="A0A194X643"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="543" mass="61080" checksum="A6D66F744C34CC8B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X668</accession>
    <name>A0A194X668_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_92510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070028.1">
        <property type="nucleotide sequence ID" value="XM_018223518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X668"/>
    <dbReference type="FunCoup" id="A0A194X668">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X668"/>
    <dbReference type="GeneID" id="28833244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_92510"/>
    <dbReference type="InParanoid" id="A0A194X668"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="22994" checksum="AD2ABFF963D79291" modified="2016-10-05" version="1">MASKTYIVEHLDDELGPWSELEYVTIAKESHEAGAKFCLSSIPSTLVLPEALKVVPGFTADGRSVETLYAEDKSRVCLLDPSATRELSPQDSEIFDVFLFGGILGDDPPRDRTSELRKKGFEGRRLGPKQMTTDTAVRVTRLVVQEKVPLDDIEYIDYPELRINKNESTEMPFRYVKGKDGLSIMPEGMIDLIKKDSEKGFGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7D4</accession>
    <name>A0A194X7D4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070438.1">
        <property type="nucleotide sequence ID" value="XM_018215171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7D4"/>
    <dbReference type="GeneID" id="28824897"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685921"/>
    <dbReference type="InParanoid" id="A0A194X7D4"/>
    <dbReference type="OrthoDB" id="10519790at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="96" mass="10702" checksum="9EF980D71D7998B1" modified="2016-10-05" version="1">MPSTILQRRLTLICCGILAVSLHLLFQLVTLSMDHSIFLNLGAAIIISYIWIKVYLFVTRETGIDPFINTAITLGSPFVAALLRDNAIKNGDWVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7K9</accession>
    <name>A0A194X7K9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_697433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070510.1">
        <property type="nucleotide sequence ID" value="XM_018216902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7K9"/>
    <dbReference type="GeneID" id="28826628"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697433"/>
    <dbReference type="InParanoid" id="A0A194X7K9"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053212">
        <property type="entry name" value="DHP_3-monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054707">
        <property type="entry name" value="DhpH_subs-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469">
        <property type="entry name" value="MONOOXYGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47469:SF2">
        <property type="entry name" value="OS06G0597600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22607">
        <property type="entry name" value="FAD_binding-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="2,6-dihydroxypyridine 3-monooxygenase substrate binding" evidence="2">
        <location>
            <begin position="180"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="404" mass="43914" checksum="B714BC40E0FBF3BF" modified="2016-10-05" version="1">MQEQAVNIVVVGGSLAGLLHAIIFKHLGHKVHVLEKSSQSTLQSQAAGLGAGPEVRKLIDEYIKTDKPYATTSSLLEIVNSQGDIINSIPTGEVIYLTTWSLLYNMLKAHLLGDRTTPPATYETEKTVRDVNYDGNKVTVTYSDTNTGISNVLQADLVIAADGAHSSVRATVLPDVHPKYAGYVTWRGAVPEASVSEASREVLENRVIIFRTEKGYTISYHVPSESGSIAAGEHQFIWIWYEMLEENSEEFRETFTDITGVTRLTTVPRGKMNPTVWVKRQASGATLSAPFAELLSKTSDPFVSAIRDFVSPKAVIYDGKLLLVGDAFALFRPHLGASTNQAAKQADGLVDVFMGKGNLAEWEKASVEYATRTSATSNALGEYCFTGNVPGRLSTAIQPDKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7X7</accession>
    <name>A0A194X7X7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Cytochrome P450</fullName>
                <ecNumber evidence="14">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="14">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_647959</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="14"/>
    <dbReference type="EC" id="1.6.2.4" evidence="14"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070267.1">
        <property type="nucleotide sequence ID" value="XM_018211980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7X7"/>
    <dbReference type="STRING" id="149040.A0A194X7X7"/>
    <dbReference type="GeneID" id="28821706"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647959"/>
    <dbReference type="InParanoid" id="A0A194X7X7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 14" id="KW-0288">FMN</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0521">NADP</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="501"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="677"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ15912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118796" checksum="10557A9992EFA6F0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8T5</accession>
    <name>A0A194X8T5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_719271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070935.1">
        <property type="nucleotide sequence ID" value="XM_018218484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8T5"/>
    <dbReference type="FunCoup" id="A0A194X8T5">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8T5"/>
    <dbReference type="GeneID" id="28828210"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719271"/>
    <dbReference type="InParanoid" id="A0A194X8T5"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="37046" checksum="F9752A369C0B6106" modified="2016-10-05" version="1">MAPSIMETEPAPDVSLKAEAKVAQNGTLRHEEYQYLDLIREILETGEHRPDRTGTGTYSLFAPKPLKFSLSSSDGTPILPLLTTKRVFLRAVIAELLWFVSGSTSSLPLAEAGIKIWDGNGSREYLDSVGLSHRAVGDLGPVYGFQWRHFGAEYVDAQTDYTGKGVDQLAEVIHKLKHNPYDRRIILSAWNPKDLKLMALPPCHMFAQFYVSYPKLENGEKGQGRLDCQLYQRSCDMGLGVPFNIASYALLTHMLAHVCNLIPGTFTHTMGDAHVYIDHVDALKVQLTREPRSFPQLEIAREKGGSIDGWKVEDFVVKGYEPHKGIAMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X946</accession>
    <name>A0A194X946_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_781987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071051.1">
        <property type="nucleotide sequence ID" value="XM_018222533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X946"/>
    <dbReference type="STRING" id="149040.A0A194X946"/>
    <dbReference type="GeneID" id="28832259"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781987"/>
    <dbReference type="InParanoid" id="A0A194X946"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267973" evidence="2">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="21348" checksum="6D7C75711AB748F3" modified="2016-10-05" version="1">MHLSTPLHLLLFLPALVCAIASTSIKQTPVQDPTSTLSSSTSTFHTLLSSSSSTVKTTTPTLLSSPSSSLKTTNPTLTSHSTLTSTTTSPSPTATNGTCLNPGTCGTFTIYPSSLCGPLARCTCALTSSNVGICVQDVLCAGATPCAKQSDCPVGDVCWVQNCCGVSICAPVGTGCSNGTVVARRQGGTGLGVGGIGGSGLGLGLGKRCASAGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9W7</accession>
    <name>A0A194X9W7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_718676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071321.1">
        <property type="nucleotide sequence ID" value="XM_018218433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9W7"/>
    <dbReference type="GeneID" id="28828159"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718676"/>
    <dbReference type="InParanoid" id="A0A194X9W7"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="348" mass="40209" checksum="A775BF48347F9CD4" modified="2016-10-05" version="1">MTSATFSGLPPEIRYDIWQLSFEPRLLCLHMHRLITPEPSDHSPSGLSKDSRKVIAVSFTCTALDSRSERTPNDVFVEYSNISPPVSVDFLRNMQVGPPGPTALGPVQLYVCRESRALAMRRYELAFGGTEQDNENLNPRQYAALEEWHRKKLWEKKIWVDFNSDVVLVEVIPRRLEFPAPPLRLPQPQPGWRALRCLNVYAPDEAKKIKRLAIGGKWPLESDLWRELGLIICLNTLLTSHTMSIEFFTNMEKLLVDDSFQNPEDVQEQVQTEEQDKLEDPKMVEEGVQKWIRDLVDCQQRRLRTDLGPERVITRPDKPVWKELPVVKVVHGNGWKRLLQNSNPEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAE9</accession>
    <name>A0A194XAE9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_616919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071500.1">
        <property type="nucleotide sequence ID" value="XM_018210781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAE9"/>
    <dbReference type="STRING" id="149040.A0A194XAE9"/>
    <dbReference type="GeneID" id="28820507"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_616919"/>
    <dbReference type="InParanoid" id="A0A194XAE9"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="454"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="561" mass="61619" checksum="6A8D469C739CE703" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAL9</accession>
    <name>A0A194XAL9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_73945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071571.1">
        <property type="nucleotide sequence ID" value="XM_018220464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAL9"/>
    <dbReference type="GeneID" id="28830190"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_73945"/>
    <dbReference type="InParanoid" id="A0A194XAL9"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25173" checksum="A50EE4E799FFA882" modified="2016-10-05" version="1">MPPITQSASATLRSLVDRSLHVSSVATRSLPTRILQLVPRQNSNPSIIPTTYGSINSGPAPGTVVGIVLGSVGGFLLLLWLIYTCLSLGGWGSRSSYEEEVVVHDRRKSRHGSTRSRRVSETVEVRRAPSPVRIVPMPMPMPPPMREPVRETVIVEEHRSRERPREVSRGSDEVVVIEEHSPPRRKKSVREREERERRESGYRTVDPGAYAGAVGGRRSSGSRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAT1</accession>
    <name>A0A194XAT1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_746789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071630.1">
        <property type="nucleotide sequence ID" value="XM_018221102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAT1"/>
    <dbReference type="GeneID" id="28830828"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746789"/>
    <dbReference type="InParanoid" id="A0A194XAT1"/>
    <dbReference type="OrthoDB" id="5413793at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="40"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="400" mass="43703" checksum="561F62FA0CF8055B" modified="2016-10-05" version="1">MSSNSTASAIPYWESPDYKGDKVRDLNASLIAITTVIVGLRLYTRGFVSKTFGVDDVLASIAFALIVTQSALDIRSVNYGSGAHIEYVPPHLVPLFFSALVNNTLIYFIGTGLMRLSIVAFLPRLAKDLSSPLFLKLVYTTGFVIVCQTLVCFFYRLTECHPIIDIWKVPTTPGLKCVSAQQEQNNLIAHQAIGIIVDFALFALPIWVINSKMMKSAKKVQVILVFSVGLFVVITGVVRMVMLNTLLFLADPTFAMSTIGPWTDLEGHAGLWVASFPALQPLIRTMSYKLGLRSALQSYGQSSGGKNNKSGAKVPGGSNNWASTVPRKSGYAKNGSGIDLDDGSERGIVAGDKSDTELDNLSADSTHIHKKVDYDVRVEEIPRGDYDDPRRVTNKSWVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB44</accession>
    <name>A0A194XB44_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_782205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071332.1">
        <property type="nucleotide sequence ID" value="XM_018222557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB44"/>
    <dbReference type="STRING" id="149040.A0A194XB44"/>
    <dbReference type="GeneID" id="28832283"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782205"/>
    <dbReference type="InParanoid" id="A0A194XB44"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="34403" checksum="EF19884C2B816E9D" modified="2016-10-05" version="1">MIPSPTPLSPPTTYETLPLTHIKVTHYPPGSPTATQVVVVSLNRPEKQNAFTVEMMGDFETIYPLLDVDERVKVIVLTGAGRTFCAGADLERGFKGGEERAVDHRDGGGRVALAIYRCRKPTVAAMQGSAVGVGMTMVLPAAIRIAHETSKYGFVFARRGITMESASSFFLPRLIGYSRAMYLITTGAVFPPTSPHFGHLFQETVKDANEVLPRAIELATEIAEHTSGLAGFLNRNLMWRGPGSAEESHLVDSAVLYHMFSNRDQREGVSSFLEKRRPRFEATVEEDAPPTFPWWVEVDTGSRAKVRKGPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC73</accession>
    <name>A0A194XC73_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_615388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071707.1">
        <property type="nucleotide sequence ID" value="XM_018210726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC73"/>
    <dbReference type="FunCoup" id="A0A194XC73">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="GeneID" id="28820452"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615388"/>
    <dbReference type="InParanoid" id="A0A194XC73"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="394" mass="46478" checksum="724681FD2571FFDA" modified="2016-10-05" version="1">MAIARPIRVLGLVAVGLWVFFLYQVFGPAKIPKGPGDTLANMERDPNLDLTGEPEGELWRADKGYGLGAEGTNRINATLLSLVRNEELEGMLQAMNDLERTWNSKFNYPWTFFNDVPFTEEFKKKTREATKAECFYELIPKEHWDVPSWIDEEIFQESAKILKENDIQYGSMKSYHQMCRWNSGLFYKHPALEHTQFYWRVEPKVHFFCDVDYDVFRYMQDFNKTYGFTINLYDAPQSIPTLWPETTKFMAQHPEYLHENHAMQWLTDSARRPEHNMKANGYSTCHFWSNFEIADMSFWRSQAYEDYFNHLDRAGGFFYERWGDAPVHSIALGLFEDSSKIHWFRDIGYQHIPYFNCPNSPKCKGCMTGRFTDGESWLMKEDCRPNWFKYVGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDP8</accession>
    <name>A0A194XDP8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_644338</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072634.1">
        <property type="nucleotide sequence ID" value="XM_018211831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDP8"/>
    <dbReference type="FunCoup" id="A0A194XDP8">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDP8"/>
    <dbReference type="GeneID" id="28821557"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644338"/>
    <dbReference type="InParanoid" id="A0A194XDP8"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="567" mass="61463" checksum="767CA30864556899" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEA3</accession>
    <name>A0A194XEA3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_37435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072447.1">
        <property type="nucleotide sequence ID" value="XM_018207074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEA3"/>
    <dbReference type="STRING" id="149040.A0A194XEA3"/>
    <dbReference type="GeneID" id="28816800"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_37435"/>
    <dbReference type="InParanoid" id="A0A194XEA3"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="19383" checksum="05F8B380B7742AEF" modified="2016-10-05" version="1">MKSSRSSLTLVDNKPPALTGSCMCGKVTYSSSVLPSDLVNCHCQTCRRLSGAPFLTFGQFPVSAITWTSATGANAMKKMTYSDIADRTHCAECGSPISMTYKCEPEAISITAGTFDEESIRGQLPRLKSHIFVEEKVKNEWYELPPNDGVPKYSGFPSVFSKKIEEWKKVLKSPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XED4</accession>
    <name>A0A194XED4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072905.1">
        <property type="nucleotide sequence ID" value="XM_018219648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XED4"/>
    <dbReference type="GeneID" id="28829374"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732109"/>
    <dbReference type="InParanoid" id="A0A194XED4"/>
    <dbReference type="OrthoDB" id="3553375at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27450" checksum="0C60D4003B2D89A5" modified="2016-10-05" version="1">MSPTSIASPILFEYRKLWLISVLVFFLSTGVFVAQYPEEMKTYGPFTLAFATFLGFAAYSSARTPLMDLVPWLPMIVWLFVLLTVYFLPRLRELFAQPLDPEDAMEQGRHHPVHRIPLDDVRIQPNVNRPGNDPMELEEWLRGMDRNSVPGLPDDLSTQGSDIELPQHSEAMAVAWRRAVRMGRQGLMTGGLSQTSSDTPYPHNLNVDVHGGHFQNSDDRFNSPSLSPAASSLPSIGAESDTPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEF8</accession>
    <name>A0A194XEF8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_613518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072913.1">
        <property type="nucleotide sequence ID" value="XM_018210665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEF8"/>
    <dbReference type="FunCoup" id="A0A194XEF8">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XEF8"/>
    <dbReference type="GeneID" id="28820391"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613518"/>
    <dbReference type="InParanoid" id="A0A194XEF8"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ18558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="45917" checksum="F266FA30A331368F" modified="2016-10-05" version="1">MASKLSPEDSIALIKANLAEVLNPEIIDNVILKEKRPLKVYWGSATTGRPHCGYFVPMMKVAELLAAGCHVKILLADIHGYLDNMKAPIDLVEFRAKYYERVIKALLKAVGVDIARLEFVLGSSYQLNKDYTMDRFKLEGITRVEVAKKAGAEVVKQSADPTLGGLIYPLMQALDEQYLDVDAQFGGVDQRKIFAFAMENLPKIGYSVRAHLMNSMVPGLGEAAKMSASDPDSKIDLLDDPAAVEKKLKKAKCPPKEVEGNGVIAFVEHVIFRAIALKVDHEPIFKVERRDEEPLLYTSIQKLKEDYAADILTPQLLKSALTHHLNELLKPIVAEYEASPDWQAISLQAYPPEKAAVKVKKVKDKGDPAKRAAAAAARKNVVAQPDGHVEGEDAEKVTVGPSTEETLQKLKVSEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFG7</accession>
    <name>A0A194XFG7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_506727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073234.1">
        <property type="nucleotide sequence ID" value="XM_018208034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFG7"/>
    <dbReference type="GeneID" id="28817760"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_506727"/>
    <dbReference type="InParanoid" id="A0A194XFG7"/>
    <dbReference type="OrthoDB" id="445803at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF6">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16889" checksum="6F1073B05791DD2A" modified="2016-10-05" version="1">MANITKPMIVPASHTSSQPLEQFENPNRGNCTWHTIFSQPQTPTDSMCSGIGTCQPRNGRLCPHRHKQAEIYYIISGKGIVRIDEKNYEVEAGSSVFIPGDAEHGVFNLGEEDLKWFYVFPTGAFKDILYRFSDEVEGKALPTVAQLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFH9</accession>
    <name>A0A194XFH9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072882.1">
        <property type="nucleotide sequence ID" value="XM_018214712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFH9"/>
    <dbReference type="GeneID" id="28824438"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683486"/>
    <dbReference type="InParanoid" id="A0A194XFH9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17325" checksum="033E0236E34D1B20" modified="2016-10-05" version="1">MSQRSVHDQRRAPSQSKNKTTSSSSQATYLPSAEPPPPISYVRIGSLVAVARADNLNKPYEFSEEAIAEIEEEWGMMVGDALARFDNRLTCGNCSQIHMKDQVFRMLSALKLEMEGAGVEDIDEGLVRGFQRDFEEIWRVYLDGAKDSDCDDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFL9</accession>
    <name>A0A194XFL9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_582205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073318.1">
        <property type="nucleotide sequence ID" value="XM_018209151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFL9"/>
    <dbReference type="STRING" id="149040.A0A194XFL9"/>
    <dbReference type="GeneID" id="28818877"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582205"/>
    <dbReference type="InParanoid" id="A0A194XFL9"/>
    <dbReference type="OrthoDB" id="5558646at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF18">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 16" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268177" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ18963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="33954" checksum="258A5115DD9ACB91" modified="2016-10-05" version="1">MRNQALLCLAALFSAASAHTIFVQLESAGTTYPINYGIRDPTYDGPITDVTTNDVACNGGPNPTTASPYVINVNAGDTVQATWRHTLTSTAANDAVYVIDPSHKGPVMAYMKKVTNATSDVGYGDGWFKISEAGLNVATQDWATTDLIANAGVQNIQIPSCIENGQYLLRAELIALHAASSYPGAQLYMECAQINVSGGSGTATPSTVSFPGTYAGTDPGILINIYQTLTTYQIPGPTPLVCGAGGAPASSSSSPASSSKAASSSAKASTTLATSTKVSSTPVASATGATAPLYGQCGGTGWTGATTCASGTCKASGAYYSECWSVVEGLRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFM1</accession>
    <name>A0A194XFM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_582689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073284.1">
        <property type="nucleotide sequence ID" value="XM_018209177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFM1"/>
    <dbReference type="STRING" id="149040.A0A194XFM1"/>
    <dbReference type="GeneID" id="28818903"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582689"/>
    <dbReference type="InParanoid" id="A0A194XFM1"/>
    <dbReference type="OrthoDB" id="526941at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="33584" checksum="46B8771FEC76AF70" modified="2016-10-05" version="1" fragment="single">PVEPEAHQTLITYVYSESYESMQNLMFFLEHGLHAKADFVFIFNGETNHTQLIPNKPNIKIVQRDNSCYDLGAHGEVLTKDDLWLKYKKFIMMNASVRGPFIPHWAEACWSDRLLSKITTDVKLVGISINCWPTPHVQSMVWATDRMGMSLLLQPPKSSPRHDGWMEVLFAHPAQFPRPDDYKTADPSWVEVGLNKCFANRQQAVEAEVAATGIMFGAAKKVDVMLMKFQTDPDYNAHCSRMGAWDPQGNGAYDGINIHPFETMFIKTNRGIDPRALALHTGWMDRSSFTSYDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFS4</accession>
    <name>A0A194XFS4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_510707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ19018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073373.1">
        <property type="nucleotide sequence ID" value="XM_018208071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFS4"/>
    <dbReference type="FunCoup" id="A0A194XFS4">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFS4"/>
    <dbReference type="GeneID" id="28817797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_510707"/>
    <dbReference type="InParanoid" id="A0A194XFS4"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="243"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="835" mass="92622" checksum="BF32C6116ED4769F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG25</accession>
    <name>A0A194XG25_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_552654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073434.1">
        <property type="nucleotide sequence ID" value="XM_018208318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG25"/>
    <dbReference type="FunCoup" id="A0A194XG25">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XG25"/>
    <dbReference type="GeneID" id="28818044"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_552654"/>
    <dbReference type="InParanoid" id="A0A194XG25"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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            <end position="79"/>
        </location>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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            <position position="125"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ19079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="125" mass="13545" checksum="D01F946082405E54" modified="2016-10-05" version="1" fragment="single">PAYKNPNPNNIEIKTKFPVARIKRIMQADEEVGKVAQVTPVAVSKALELFMIALVSGAADKAREKGGKKVTAQHLKQVVLGSPEQFDFLAEIVGRVSEAQEGAGGEAKKRKEKVEASDSSEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGG1</accession>
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        </submittedName>
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        <name type="common">Conifer needle endophyte fungus</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <end position="144"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29198" checksum="B26F228CDC53C71F" modified="2016-10-05" version="1">MATSQSGQPDESPYPSYKELRRNQLSVNSTDAVNCLFWHFDGVFPAAISVMTTPRTPNSLKPYFQPEAGGSGSGTWHQIARLPITEPKVSSIEISVSDLESWRNSWLEQHKEHPEGEYVTYGDLSDDERPYPSEEGGWESDSDTPYLVRCCGEDRPPNETAKLVVTPSAGNHFVTVQDYVSTVHPWLMSLREDILQAKKVVNYYPQPMPTDFMVIGMVPDNIRIEDKQYWIEGFRPGGRLPRNAHEASIIDRLRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGJ5</accession>
    <name>A0A194XGJ5_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="28829323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731669"/>
    <dbReference type="InParanoid" id="A0A194XGJ5"/>
    <dbReference type="OrthoDB" id="4898142at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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            <end position="210"/>
        </location>
    </feature>
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        <location>
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            <end position="410"/>
        </location>
    </feature>
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        <location>
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            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="512"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
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            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
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            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="570" mass="62770" checksum="4BBC494AD1FD3E25" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGR4</accession>
    <name>A0A194XGR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter Cdr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_706121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073686.1">
        <property type="nucleotide sequence ID" value="XM_018217500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28827226"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706121"/>
    <dbReference type="InParanoid" id="A0A194XGR4"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
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</entry>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074162.1">
        <property type="nucleotide sequence ID" value="XM_018212926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ78"/>
    <dbReference type="GeneID" id="28822652"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666658"/>
    <dbReference type="InParanoid" id="A0A194XJ78"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="170" mass="19855" checksum="C6E432014859611F" modified="2016-10-05" version="1">MAILETAWVESDSMLGYIAYVYEHTTTGSPLRNFFVDHFAYGLRCIDMEKLDAYPKEMLGEVVSLFCLATSFIVGEKCEDDASYRPMQDDLGNFQYGFFKDWRDYQVPVYDDSRVFQSPYSDLDPRTNSLSKLLFVGKARFQNPSPKARRNGFRMLCRDRMVELKEESMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJA3</accession>
    <name>A0A194XJA3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_695483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074192.1">
        <property type="nucleotide sequence ID" value="XM_018216765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJA3"/>
    <dbReference type="STRING" id="149040.A0A194XJA3"/>
    <dbReference type="GeneID" id="28826491"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695483"/>
    <dbReference type="InParanoid" id="A0A194XJA3"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32559" checksum="81E6A12E18977CB0" modified="2016-10-05" version="1">MSSYTPLQDKTENDSQQGEDYDHLLPQEESLLRKSPRRIPTWILVVLLPVVSLLFMGFGAWIGSHWLVDFNARCLEHVQHWSPIQRDVDNSYHTVLFNGSFMKQNIFRQEAGPEVDAAWESMGINYRSITIPLSDAEKTGLSPSQVQINPRYGGGYPANVEGLHHLHCLNLVRQSLYYNIDYYRAQGTGAFVNEEPILRHHVSHCLDIVRQQLMCQPDTGMLGQVWWDKEAPKAFVDFNTRHQCKDFEGIRRWAEERQIGEVVPGDFLMPPRRREDVLDSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK48</accession>
    <name>A0A194XK48_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_445363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074871.1">
        <property type="nucleotide sequence ID" value="XM_018207579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK48"/>
    <dbReference type="STRING" id="149040.A0A194XK48"/>
    <dbReference type="GeneID" id="28817305"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_445363"/>
    <dbReference type="InParanoid" id="A0A194XK48"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="934" mass="101232" checksum="C576FA45214D2ADF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLN4</accession>
    <name>A0A194XLN4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_422207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075349.1">
        <property type="nucleotide sequence ID" value="XM_018207415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLN4"/>
    <dbReference type="FunCoup" id="A0A194XLN4">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLN4"/>
    <dbReference type="GeneID" id="28817141"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_422207"/>
    <dbReference type="InParanoid" id="A0A194XLN4"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="110" mass="12595" checksum="026B8FD6DB5BB1E8" modified="2016-10-05" version="1">MGLSYNVYLNSHKIYGCKNCKAHLSNHEDIISRNFRGQHGKAYLFNNVVNVTAGEASERNMTTGRHIVRDISCRQCNETVGWKYDKAFESSEKYKEGKFILEAELLCNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLP0</accession>
    <name>A0A194XLP0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_568306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075406.1">
        <property type="nucleotide sequence ID" value="XM_018208566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLP0"/>
    <dbReference type="FunCoup" id="A0A194XLP0">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="GeneID" id="28818292"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_568306"/>
    <dbReference type="InParanoid" id="A0A194XLP0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="4">
        <location>
            <begin position="434"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="664" mass="72656" checksum="BAE6F930788EC527" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM53</accession>
    <name>A0A194XM53_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stem cell self-renewal protein Piwi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_577612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075680.1">
        <property type="nucleotide sequence ID" value="XM_018208904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM53"/>
    <dbReference type="STRING" id="149040.A0A194XM53"/>
    <dbReference type="GeneID" id="28818630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577612"/>
    <dbReference type="InParanoid" id="A0A194XM53"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="34025" checksum="F910120BF5E1E622" modified="2016-10-05" version="1" fragment="single">LKFNFKNGGTNHRVHSLGIKPNTMIVGADVTHPGRDADETCPSLAGTVATYEESHAHYLASARMQKKNEHIEQLSDMMFEHLQAYYTKRKKVWPDHILFYRDGVSESQYGMVKTDELPEIKAAIERVRQTAPGRNYMPKITLVVVGKRHHSRFYPANKPEDSRSLCAGHVMDTNVVIPHAFNFYLQSHDSALGTAKPAHYVVIVDESGYGGGKLQEVTNDLCSLGSRSMNTLSVCTPARYADLLCNRLRVYMKPVMDGKLDIPEINAVNSYQRNRDIWGIGRNTGNNNPWHENVKDVMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNB5</accession>
    <name>A0A194XNB5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_576629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075944.1">
        <property type="nucleotide sequence ID" value="XM_018208847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNB5"/>
    <dbReference type="STRING" id="149040.A0A194XNB5"/>
    <dbReference type="GeneID" id="28818573"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_576629"/>
    <dbReference type="InParanoid" id="A0A194XNB5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="527" mass="59288" checksum="FDA8F96065D6883A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNG9</accession>
    <name>A0A194XNG9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_380683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_380683"/>
    <dbReference type="InParanoid" id="A0A194XNG9"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="79" mass="9598" checksum="52C7E0BA7DE0519A" modified="2016-10-05" version="1">MTRTFGSFAIDTLKLFLIHWEAFEPHYRLKNKPTDWLAYAMFPLFWTTFRSITYLFFHAATCPVRKEYGWMIAKRDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNN1</accession>
    <name>A0A194XNN1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_432171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075692.1">
        <property type="nucleotide sequence ID" value="XM_018207477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNN1"/>
    <dbReference type="GeneID" id="28817203"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_432171"/>
    <dbReference type="InParanoid" id="A0A194XNN1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF158">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="57367" checksum="0A7C716BEAD790DA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNX5</accession>
    <name>A0A194XNX5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import translocase, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_681243</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076221.1">
        <property type="nucleotide sequence ID" value="XM_018214243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNX5"/>
    <dbReference type="FunCoup" id="A0A194XNX5">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNX5"/>
    <dbReference type="GeneID" id="28823969"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681243"/>
    <dbReference type="InParanoid" id="A0A194XNX5"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="153" mass="16690" checksum="68EC8D6EAC76458E" modified="2016-10-05" version="1">MVELVEVEDESFESKQIGPSDNEEDYYTDTDSEISTDDEDVPDEETIADRLVALKDMIPPTTRSYIAGKVETTTSWFKSGLLFSGKTLWVISTSALLLGVPWALAFAEEQQMVEMEKEMRMREMGGELLSSGGSGTAGALNAQLGAQQGKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPD0</accession>
    <name>A0A194XPD0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_665166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076376.1">
        <property type="nucleotide sequence ID" value="XM_018212825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPD0"/>
    <dbReference type="GeneID" id="28822551"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665166"/>
    <dbReference type="InParanoid" id="A0A194XPD0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="24480" checksum="E9C2FDAB0968B05C" modified="2016-10-05" version="1">MAPGGTNDTWYCCKASLREMYLPDKYKQEAVAVAQLHKFFWSGHSGEVMAEFPGRPQRMPRIIIEVRKDLSKKGHRRAYVGLSQFCHDNGDDLWYEVDDARWTHWQSGFSRDATSDHHCLPCRQFHQYNVWRLQRPDWDCLPLKNDVSDMDALAHNFEQMGKKDGKKRNATEAHFRKESVSNYQSGMHKKACTDTASEASTDDTFVKEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPH7</accession>
    <name>A0A194XPH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_393538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076448.1">
        <property type="nucleotide sequence ID" value="XM_018207210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPH7"/>
    <dbReference type="GeneID" id="28816936"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_393538"/>
    <dbReference type="InParanoid" id="A0A194XPH7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="17902" checksum="17B766C155850BC9" modified="2016-10-05" version="1">MRGTLDELYDPSHFKEPGIGSNNACFPETRAAPIISPWLGNLLTKKEACSCGFRPYRACPFASGTLRTVMHEWSDFGFTLRPGHNSFCPGRCLGSSLSGSRCRLAKRCRFGDHVGIYILPVHADQDRDASRRADCLGVDRTFIGHQSMGFSAIQSSNQGASWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPL6</accession>
    <name>A0A194XPL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_729195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076037.1">
        <property type="nucleotide sequence ID" value="XM_018219353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPL6"/>
    <dbReference type="GeneID" id="28829079"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729195"/>
    <dbReference type="InParanoid" id="A0A194XPL6"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000165">
        <property type="entry name" value="Serine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="505" mass="56490" checksum="55B483A50E2E9A0D" modified="2016-10-05" version="1">MPPKPIPPPLEIPASFAALATNGNSTFQQLLNHSDPSKGTFSQRYWYSFEYWKGPGSPVVLFTPGEEDASGYTGYMDNITITGHFGQAIDGAVIVLEHRYWGDSSPYSYLDTENLQLLNLDQAIHDLVYFAQTVDLPFDTNHSSNAQNAPWVLSGGSYSGALTAYTEHVSPGTFWAYHASSAPVEAIKDYWQYFYPVQQGMPQNCSSDVTLVIDYIDEILTTGTDDEIYALKKSFGLEGLEHNDDFASALENGPWQWQSIALYSGYSEFFEFCDAVETFALQGSNTTAPATGVGLEKALAGYANWVNTSLIPGFCQYYGYTDERDLSCFDTYNASMSFYTDYTVGNPWNRQWNWFLCNQPLDFWQDGAPRGTPTIVSRLVTAEYWQRQCALQFPEVNGYTYGSTNPNVNVHSVNKYTEGWRLEDTTRLTWTNGEFDPWRTGSMSSQFRPGGPLNSTAQHPLHLIPGGIHCYDLIMASGLASPAVQEIIDAETAQIVEWVAEYYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRG5</accession>
    <name>A0A194XRG5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_310725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077138.1">
        <property type="nucleotide sequence ID" value="XM_018206628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRG5"/>
    <dbReference type="GeneID" id="28816354"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_310725"/>
    <dbReference type="InParanoid" id="A0A194XRG5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="51" mass="5986" checksum="6BC0BF22F62CA980" modified="2016-10-05" version="1">MCLVQKKGYLARSRLIYRNYASVFGQHFPQQLTRRYANITHTASKNSTHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRX2</accession>
    <name>A0A194XRX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_300263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076827.1">
        <property type="nucleotide sequence ID" value="XM_018206566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRX2"/>
    <dbReference type="GeneID" id="28816292"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_300263"/>
    <dbReference type="InParanoid" id="A0A194XRX2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="18072" checksum="84DFDC847F8E5C80" modified="2016-10-05" version="1">MHARWLRARMASRGDGVVHPIRRRAAKQKSCEERETRWQPLKTRSTPPKCTLDKHHQRARQHDTGSRTHWALPNVSNCMLLFFRKRRHPTIPVLCLVRQHELPLCSLIIAHDLRGSRRPGLSIVIQSFSPPGAFSFHFREPAPPCIALEAISRVWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS28</accession>
    <name>A0A194XS28_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_714560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077209.1">
        <property type="nucleotide sequence ID" value="XM_018218139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS28"/>
    <dbReference type="GeneID" id="28827865"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714560"/>
    <dbReference type="InParanoid" id="A0A194XS28"/>
    <dbReference type="OrthoDB" id="5407772at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="524" mass="56183" checksum="4121B0848CBF184A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS62</accession>
    <name>A0A194XS62_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_540464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077239.1">
        <property type="nucleotide sequence ID" value="XM_018208161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS62"/>
    <dbReference type="GeneID" id="28817887"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_540464"/>
    <dbReference type="InParanoid" id="A0A194XS62"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268588" evidence="1">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="12968" checksum="41D020F32FE3DBCA" modified="2016-10-05" version="1" fragment="single">TTVAVLASTLISSTSAIITGVEAPSTVYAYNPFTVTLTTADYIQSVYDVAVAFGVAPGAGYPESLGNVMSTAYLGPSKSNILTPITFDVTLPSGTQNGPYTLSAEVFSLFGAAYSGSVSSFNTTITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS75</accession>
    <name>A0A194XS75_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative cytochrome P450 alkane hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_165383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077403.1">
        <property type="nucleotide sequence ID" value="XM_018205522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS75"/>
    <dbReference type="GeneID" id="28815248"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_165383"/>
    <dbReference type="InParanoid" id="A0A194XS75"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="57657" checksum="680E2F95FE580A76" modified="2016-10-05" version="1">MAFSFYYALAALVVVVGVVLQKIVNHIRVARFKKQHGCKPEFRIPQRERIIGYGLYQTQLKASKEKNMTTVSRQRYLDYGNTWSGQMMGQKFFNTIEPENLKHFLATDFKDFGLGRRQEAFGPLLGQGIFTTDGAQWEHSRALVRPNFTKSQVADLDTFESHIQRLVTKIPRDGSTIDLQPLFFQLTLDSATEFLFGESVNSLTSPAGSEQEIFGRCFDYAQGQLGQRSRLGKLVHVFPDKEFDQACKTVHRFVDNIVFRALERSQPKDAEKSIDGKGGKERYVFLTELMNSTRDPKQLRDELLNILLAGRDTTASLLSNTFHVLARRPDIWSKLKAEVDQLNGEKPDYDTLRNMKYLKYLLNESLRLYPVVPGNARFANRDTILPRGGGPDGLSPIFVPKGDIVAWSTFSMHRRFDIYGPDALEFRPERWAPEENLRPGWGYLPFNGGPRICVGQQFALTEASYTTVRLLQEFGGLEDRDGSEWCEQLSLTCASGRGVKVALVPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSE1</accession>
    <name>A0A194XSE1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_173855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077575.1">
        <property type="nucleotide sequence ID" value="XM_018205576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSE1"/>
    <dbReference type="STRING" id="149040.A0A194XSE1"/>
    <dbReference type="GeneID" id="28815302"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_173855"/>
    <dbReference type="InParanoid" id="A0A194XSE1"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14029" checksum="96BEFDD0DE4662D5" modified="2016-10-05" version="1">MSGKAPSTRLSTAEAILAAYNSLSTSALEPLLDSSFTKEILPKSLGEPTSDRESYLKQSEAFPLMFSSSIITPREIFEDDTRNAVVVYGGMKAEFVGGKGVIENEFVMVMFMSEDGKKVVKMLDFRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A194XT18"/>
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            <end position="137"/>
        </location>
    </feature>
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            <end position="181"/>
        </location>
    </feature>
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            <end position="209"/>
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    </feature>
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    </feature>
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        <location>
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            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="636"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22862.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="745" mass="84440" checksum="503D8A3FF6165981" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTA3</accession>
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        </submittedName>
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        <name evidence="2" type="ORF">LY89DRAFT_777059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="539" mass="58846" checksum="FA89D97EAAEE20AB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="10 11">
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214001.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XTB8"/>
    <dbReference type="GeneID" id="28823727"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680069"/>
    <dbReference type="InParanoid" id="A0A194XTB8"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
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            <end position="113"/>
        </location>
    </feature>
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        </location>
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            <end position="56"/>
        </location>
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        </location>
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    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ23294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="293" mass="32054" checksum="41ADDAF4AD154FBC" modified="2016-10-05" version="1">MAAGTIDIDKPGKYPIVLSDALLGKTSKNVYTGIRYNHKPDTSSDSSSALLQPSSDSDSRYDLTLTDASKMYSYEGSRTSADGQYVLIFDPMKKHFVLHRVDSTFDMNLVSAPWSSDVRDQYPQIEPSEPKPAATTAPQRKASKGGKKAAATKSTTAKASIPRQKVEKPKKAAKPAPPPREPTPEPEKDSDDGLTIEYPDAPASRPSANNSQAYNSTPVFHRNVSEDVSDEDEDAEGEEYEDERERNQDVDHLKLPSPAGNVGGMSDEDIEDELEAELEKALDANESDESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUJ3</accession>
    <name>A0A194XUJ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_755280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUJ3"/>
    <dbReference type="GeneID" id="28831072"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_755280"/>
    <dbReference type="InParanoid" id="A0A194XUJ3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="190" mass="21127" checksum="39340E12DB4299D5" modified="2016-10-05" version="1">MNPQVKAVKASRASDEMQVSPTPKSMEQKSAGQKSAGQKLKRKLDSTDKPPASASDGKKRKQDDALSATSKPTSSKQTRPSTATTKGKKATQQTSSTKAAPTKSEDQECRFCLDGDGKWAGFDEYAYKPEFYTELCFECKDTVLKNSCRVCKQLCIDDEYMLPEREDMCRTCERKAFDRILLGYGVGDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUR3</accession>
    <name>A0A194XUR3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_604431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078415.1">
        <property type="nucleotide sequence ID" value="XM_018210356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUR3"/>
    <dbReference type="FunCoup" id="A0A194XUR3">
        <property type="interactions" value="954"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUR3"/>
    <dbReference type="GeneID" id="28820082"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604431"/>
    <dbReference type="InParanoid" id="A0A194XUR3"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ24060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16842" checksum="0666189170A1D87A" modified="2016-10-05" version="1">MGRLHSNGKGISASALPYSRTPPAWLKTTPEQVVDQICKLAKKGATPSQIGVVLRDSHGIAQVKVVTGNKILRILKSNGLAPEIPEDLYMLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKTVGVLPPTWRYESATASTMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV00</accession>
    <name>A0A194XV00_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_13555</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078505.1">
        <property type="nucleotide sequence ID" value="XM_018205270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV00"/>
    <dbReference type="FunCoup" id="A0A194XV00">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XV00"/>
    <dbReference type="GeneID" id="28814996"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_13555"/>
    <dbReference type="InParanoid" id="A0A194XV00"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ24150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1183" mass="125160" checksum="0B3680E2B1080F03" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV27</accession>
    <name>A0A194XV27_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_10584</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_10584"/>
    <dbReference type="InParanoid" id="A0A194XV27"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Probable endonuclease lcl3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
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            <end position="239"/>
        </location>
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        </location>
    </feature>
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            <end position="250"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="30277" checksum="69C5E1AE9716002A" modified="2016-10-05" version="1">MRWPPWSTESERDRDEKKKPVSWTDNLNATDWSHYTDPRTIIPTILLTTTILASARLYRTYLRRIPEAAHIKPTFFRKRSLFGTVTRVGDADGCRLFHTPGGRLMGWGWLPWRKVPSNVSDLKNNTISIRLAGIDAPEGAHFGKTAQPYSAEAMEWLKSYILNRRVRAYIYKQDQYSRIVATVFVRRFLFRRDVGKEMLKRGLATIYDAKMGAEFGDFEEEYRKVEKVAKRKKLGMWSGKDYESPMDYKKRTAAQNEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV35</accession>
    <name>A0A194XV35_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_571959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV35"/>
    <dbReference type="GeneID" id="28818343"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_571959"/>
    <dbReference type="InParanoid" id="A0A194XV35"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="64" mass="6965" checksum="F9E25295D721B59D" modified="2016-10-05" version="1" fragment="single">HTSVAAQNLCAFGKINTFFQTGQLPGTDNYCPLEAGPWNITLPGPLSSFNDKRDIKESLVKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVT9</accession>
    <name>A0A194XVT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_13015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078484.1">
        <property type="nucleotide sequence ID" value="XM_018205235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVT9"/>
    <dbReference type="STRING" id="149040.A0A194XVT9"/>
    <dbReference type="GeneID" id="28814961"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_13015"/>
    <dbReference type="InParanoid" id="A0A194XVT9"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000114">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="12">
        <location>
            <begin position="445"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ24129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="881" mass="96638" checksum="06215C81766AC453" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW12</accession>
    <name>A0A194XW12_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_634626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078855.1">
        <property type="nucleotide sequence ID" value="XM_018211400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW12"/>
    <dbReference type="GeneID" id="28821126"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634626"/>
    <dbReference type="InParanoid" id="A0A194XW12"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="596" mass="67671" checksum="4C3C0C7004567852" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW86</accession>
    <name>A0A194XW86_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_23759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078853.1">
        <property type="nucleotide sequence ID" value="XM_018206074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW86"/>
    <dbReference type="GeneID" id="28815800"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_23759"/>
    <dbReference type="InParanoid" id="A0A194XW86"/>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="866" mass="93884" checksum="008B0CA48265A197" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXJ0</accession>
    <name>A0A194XXJ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_663261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078887.1">
        <property type="nucleotide sequence ID" value="XM_018212692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXJ0"/>
    <dbReference type="STRING" id="149040.A0A194XXJ0"/>
    <dbReference type="GeneID" id="28822418"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663261"/>
    <dbReference type="InParanoid" id="A0A194XXJ0"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="65"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="273"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="547"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="888" mass="98240" checksum="091FABA5E66B6B30" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2A8</accession>
    <name>A0A132B2A8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_678722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213767.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28823493"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678722"/>
    <dbReference type="InParanoid" id="A0A132B2A8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="227" mass="25450" checksum="A60A40D28AB5012C" modified="2016-05-11" version="1">MTMFSPLRDPDDFGDVLQDFDSIELESQSSKHSRTSNTPSHDLESQRQMPKTSRSVSKLLTFCCLSNNRESSTERRKCNMDTCLSISLILKNSFCAILAAGISCLVIALVILVIRNTPDVDEIIKKIAGIAEALGPQDVLNKVTILLLDRNDPYPNIPCHLFDSQKHIQIDLTWCSQEFIERYGYGPTQLGQMISSNALGLAQPASQRWNWTPEMSDLGLQRIPVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2K1</accession>
    <name>A0A132B2K1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_555096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060980.1">
        <property type="nucleotide sequence ID" value="XM_018208356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2K1"/>
    <dbReference type="STRING" id="149040.A0A132B2K1"/>
    <dbReference type="GeneID" id="28818082"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_555096"/>
    <dbReference type="InParanoid" id="A0A132B2K1"/>
    <dbReference type="OrthoDB" id="5075206at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10876" checksum="C11196329DF8688F" modified="2016-05-11" version="1" fragment="single">MAISEGKSLLFILPCILPNARVTILVLPLVSLRGDLLRRVRELGIDHLVWAPGEQQDAPLVFVTVEAACTEQFRTYAHKLAATQDLGRIVFDEAHLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3E0</accession>
    <name>A0A132B3E0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_602609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061206.1">
        <property type="nucleotide sequence ID" value="XM_018210256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3E0"/>
    <dbReference type="STRING" id="149040.A0A132B3E0"/>
    <dbReference type="GeneID" id="28819982"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602609"/>
    <dbReference type="InParanoid" id="A0A132B3E0"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="33919" checksum="D868998E50EB484C" modified="2016-05-11" version="1">MSAFTPPSSYGHVPGFSQIKLSHHPPTSQEVTPIIILTLSRVEKNNAFTSTMENDMVRAFDMLDQDDRVKVIVVTGEGKNFCAGADLEIGLERTAGIGPKDHRDGGGRTALAIHRCRKPTIAAIQGAAIGVGITMTLPMSIRVAWEGAKIGFVFSQRGVVMEAASSFFLPRLIGHSRAIYLTTTGSVIPAASPAFEDLFHAILPSPEEVLPYALTIAEQIAAQTSTVSTYLMREMIWRNPGSAEGAHLLDSEIMWELYGKEDKKEGVKAFLEKRSPKMTGDLKQGMPSNVPWWEPINTVPRSGIRSDKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3I6</accession>
    <name>A0A132B3I6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_372847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061301.1">
        <property type="nucleotide sequence ID" value="XM_018207068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3I6"/>
    <dbReference type="STRING" id="149040.A0A132B3I6"/>
    <dbReference type="GeneID" id="28816794"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_372847"/>
    <dbReference type="InParanoid" id="A0A132B3I6"/>
    <dbReference type="OrthoDB" id="3561261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="35980" checksum="9680861E320DBD09" modified="2016-05-11" version="1">MDEFTELEAQASSDEENLSMHENQFHPRNYGFKWPDAETADIRAELMRRGLSQYGCREELCDRLRGDNEFVLSSEGRHDIYERKLAVIKDQEAAANLVPFQRFSDLPTELRFKIWKLSLPGPRVLSVSDFRKGSAAMLHFREHDNKPNPAALTVCRESREIALRRYRLCFGTPNIYADLTSDILYFGSNWDCVNVFRNGVVAWASWIKTAMRARGQEMPNVLISDLQQVKNLALPRRMWDMITHLGTGDRVSAGIELRRKLILWVSLKQLILVEDDKKDVDMLFSLTPGHTIFEDSTHPCEDAELAREGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3M9</accession>
    <name>A0A132B3M9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_692028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061296.1">
        <property type="nucleotide sequence ID" value="XM_018216456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3M9"/>
    <dbReference type="GeneID" id="28826182"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692028"/>
    <dbReference type="InParanoid" id="A0A132B3M9"/>
    <dbReference type="OrthoDB" id="3560159at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24329" checksum="5FBBCCB2F29FADCF" modified="2016-05-11" version="1">MDIDKSRNKPLYKDDHTPVDIAPNGDVLFIVGPLKRRVRVYSLILKNASKPFATLLGPQFSEGQALLEHNPSEPVHLSLPEDDFDAIVTIFSILHGRNRNFNKELSSKEVLNVAITADKWCCVVPLWWAAKDWLKCDGITDSKVLWALTLTAYLLDEEKSCAIQLQPWFCTIRGRNRMTILMKLLVLMMIRWHLFESHSVLKGLASAYLWLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B462</accession>
    <name>A0A132B462_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_790482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060812.1">
        <property type="nucleotide sequence ID" value="XM_018223373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B462"/>
    <dbReference type="STRING" id="149040.A0A132B462"/>
    <dbReference type="GeneID" id="28833099"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790482"/>
    <dbReference type="InParanoid" id="A0A132B462"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF382">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287827" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="671" mass="74283" checksum="B13786D5443B0EA8" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5Q1</accession>
    <name>A0A132B5Q1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_691426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062026.1">
        <property type="nucleotide sequence ID" value="XM_018216318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5Q1"/>
    <dbReference type="FunCoup" id="A0A132B5Q1">
        <property type="interactions" value="1075"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B5Q1"/>
    <dbReference type="GeneID" id="28826044"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691426"/>
    <dbReference type="InParanoid" id="A0A132B5Q1"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001144">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="8"/>
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        <property type="match status" value="11"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="520"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
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            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="722"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="893" mass="97479" checksum="9BEB1CDD5728D481" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5W7</accession>
    <name>A0A132B5W7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_361654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_361654"/>
    <dbReference type="InParanoid" id="A0A132B5W7"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ07284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17077" checksum="C9CB949F61BE83A4" modified="2016-05-11" version="1">MRPIQASFRHKCIAGSMNSKVRPYLLCVLMEYIMELQSLMKMLSPCGISDLPVFESAYCAPIPGCFYTLMHLRHLRINHSRTGRSLVALVRGTLLQEQPGYPDYFVDALYYLALGGQQRLTTLGPDVADRSCVPEVNLLYHFTRMISNEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6G8</accession>
    <name>A0A132B6G8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_541919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28817913"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541919"/>
    <dbReference type="InParanoid" id="A0A132B6G8"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="214" mass="24474" checksum="91ECC0644E1A4210" modified="2016-05-11" version="1" fragment="single">IQQTPFIKQLAASDRPTRDAALHSLRTFLSARRSLPPLELLKLWKGLFYCLWMSDRPKPQAALAQELANLLTILPSLPEKIEFLRAFWKTMQREWTNIDVLRMEKFLLLVRRFLAATFVAAKEGKMEWEEERVGMLVRTLEEVPCEVEDVKVPNGLRFHVIDIYVDELERVGALEEGSEAPIEILLGPLKALAKGSPTKAVRNKAKEALADERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6V2</accession>
    <name>A0A132B6V2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_659617</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062318.1">
        <property type="nucleotide sequence ID" value="XM_018212523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6V2"/>
    <dbReference type="FunCoup" id="A0A132B6V2">
        <property type="interactions" value="1127"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6V2"/>
    <dbReference type="GeneID" id="28822249"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659617"/>
    <dbReference type="InParanoid" id="A0A132B6V2"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7J4</accession>
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KUJ08223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="18693" checksum="1782841EEF7270D3" modified="2016-05-11" version="1">MKRTLSGSRVQQDVNASKLPYHEIKSPFKIEDLSIPPEAQKHVEYLSRFPLSQVCQWVEIWQRSEAQGNSRRDLEDYCFHNKFNDFSEAKPEIAAMEIERVPIQSERLNVTFPLPTVGEPLGKHARRIYPCSFCDKTFSRKGGWKKHEGSFHQPQKQWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7X0</accession>
    <name>A0A132B7X0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">LY89DRAFT_788841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223199.1"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="HOOK N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="200"/>
            <end position="380"/>
        </location>
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    <feature type="coiled-coil region" evidence="4">
        <location>
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        </location>
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    <feature type="coiled-coil region" evidence="4">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="769" mass="87972" checksum="BEA2F6E932416E31" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8F8</accession>
    <name>A0A132B8F8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062519.1">
        <property type="nucleotide sequence ID" value="XM_018216229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8F8"/>
    <dbReference type="GeneID" id="28825955"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691069"/>
    <dbReference type="InParanoid" id="A0A132B8F8"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17975" checksum="A67A47F3DECC8A32" modified="2016-05-11" version="1">MGLVRGFEMTMGYIAHSVFRFIQLVLALTVCGLYGVDLHKANQEHKYTDGKWAYAEVVASLSAFTAVLYIIPFMSRVPFAFVWDTILFVLWIVLFGIFGNMYIHANAQGDSGIIRMKHAVWIDLTNALLWLISAVGMAWYYFKHRNNKTRWTGRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Q6</accession>
    <name>A0A132B8Q6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_659119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062988.1">
        <property type="nucleotide sequence ID" value="XM_018212504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8Q6"/>
    <dbReference type="STRING" id="149040.A0A132B8Q6"/>
    <dbReference type="GeneID" id="28822230"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659119"/>
    <dbReference type="InParanoid" id="A0A132B8Q6"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="107" mass="12808" checksum="30B0356C4D168DC5" modified="2016-05-11" version="1">MVYTLTVHLYANEKPDSIDRIKAKLIEAARVYRKDKETIDWLVMQDVHDPRAFTIVERFENESSQKYHLENPYWKTFDPYVIPLLDKKMDLRRHEELDTSKDVAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8X6</accession>
    <name>A0A132B8X6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_788748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063213.1">
        <property type="nucleotide sequence ID" value="XM_018223192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8X6"/>
    <dbReference type="STRING" id="149040.A0A132B8X6"/>
    <dbReference type="GeneID" id="28832918"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788748"/>
    <dbReference type="InParanoid" id="A0A132B8X6"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="238" mass="26866" checksum="973DE27EE6316262" modified="2016-05-11" version="1">MTVANGMGTAIFPAHFYNALRQKQNGIAPWPIMEELIAIHGENRLFLGSKPTTIMDSYKQIVLTLGHSVADFSANLRKRKLRPSKNGPRGLKESSPLSEIFRQNWTVEGNVVIDKSALTLHRVEALLTEQALDEEIAGNPVSKRVRHKMAVSKQLSPLDLLDALMVSIPRELPKLQYDYFELHRQSIGVLRKVCAEMDEDFKRYIGEGYLENESQLPFLGPYEHGDKSPCVQAVEPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9I6</accession>
    <name>A0A132B9I6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_332794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062889.1">
        <property type="nucleotide sequence ID" value="XM_018206804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9I6"/>
    <dbReference type="STRING" id="149040.A0A132B9I6"/>
    <dbReference type="GeneID" id="28816530"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_332794"/>
    <dbReference type="InParanoid" id="A0A132B9I6"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="444" mass="50580" checksum="E3445D6166E78AB2" modified="2016-05-11" version="1">MPRNELRSKTGCMSCRRRKKKCDEKRPACGGCSRSFLTCQWPTEEQNALDRRYRKGLNHPSAKSQEVKLQETAIGFKWDESALLAYFGNTVAPSYIQKGSHPHFHSMDSVFSLVEKHDTAKHAIMNCAATSLSGNFTIDRDWTGRMRSHALSLRISAIAEIQRQIKSGIIDGTEDWLLLSATQLALADSFGYNISTPIIHMHGIMSLLRCRQFARTSNPELYRPSTESLVHERISYEALLFHGITLMLFNREFYMLNQPWWHTIDEYFRSAPLSIALDEASWPILGMPFSLFRLAVLAHELNRQCPLSKEGKQLAISSLLQLNFFHKYIPSTGYFSAGYTYLAATTALLRNMISRSGNDIEVPEEAHEAPKTDISKIEANINAKKFFIRYPLWPLAVLYRVSEVEAEKKTLERLIEDALRNIRGVVFKPPPRKAVAIFMMTPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9V4</accession>
    <name>A0A132B9V4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_676543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063540.1">
        <property type="nucleotide sequence ID" value="XM_018213599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9V4"/>
    <dbReference type="FunCoup" id="A0A132B9V4">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="28823325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676543"/>
    <dbReference type="InParanoid" id="A0A132B9V4"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="33111" checksum="50BD6BA78DBC580D" modified="2016-05-11" version="1">MSVAGEKYYLYHYNPSRPAAIVFIACFAITTLLHTFQLLKKRTWYFIPFLIGGFFETLGYVGRALNAGQTYGNWTTGPYIMQSLLLLLAPALFAASIYMVLGRIIVLTDGEAHSPIRVKWLTKVFVAGDVISFLAQSGGGGMLAKAKSKSDTNTGEHVITVGLGIQVLFFGLFIIVAGIFNYRLRAMPSLRSKQLTVPWQSYLFVLYGASLMIMIRSVFRIAEYVMGQDGFLLAHEYFLHIFDATLMFLTMVLFNVYHPSRIITKATLKGHNRDPESQDSRYELRQESVAMGPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA34</accession>
    <name>A0A132BA34_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LY89DRAFT_598327</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063621.1">
        <property type="nucleotide sequence ID" value="XM_018210034.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A132BA34">
        <property type="interactions" value="1216"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BA34"/>
    <dbReference type="GeneID" id="28819760"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598327"/>
    <dbReference type="InParanoid" id="A0A132BA34"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000017">
        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="1424"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="2111"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="22">
        <location>
            <begin position="2419"/>
            <end position="2451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KUJ09266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2451" mass="277098" checksum="560FA4BBF45B51FD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB65</accession>
    <name>A0A132BB65_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_788490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063439.1">
        <property type="nucleotide sequence ID" value="XM_018223174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB65"/>
    <dbReference type="STRING" id="149040.A0A132BB65"/>
    <dbReference type="GeneID" id="28832900"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788490"/>
    <dbReference type="InParanoid" id="A0A132BB65"/>
    <dbReference type="OrthoDB" id="3852249at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046486">
        <property type="entry name" value="DUF6579"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20219">
        <property type="entry name" value="DUF6579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="499" mass="54860" checksum="AD3ECC1DE4C88EA0" modified="2016-05-11" version="1">MTLGLHPNPIGAALRLQPGLCRFNSSTGECDQLACMRPLLVGTKRQPRGFGRLIRSGGRPADCLSCKITDTTPELTSTTTYKRNSTISATTLDSVIPPNARPPSRQQQVLRSEQHSPCANYQYIPNMEHTTTINSLSKMEAFVLLKKYGPEALLKAVSKNYVGLAQTISGVFTDHNARQTFEEQRKVYEAINKAIPELLKLIESKEIRVVQNAFNSTPAFVSVFQSTALIAIGLAILDLKNAINRVGSALEGIRSELTLGNVEKIQGWGEGDFGWHVHRFVQDEMAAFSDPEEHHFFYVWNPDPDWYPRFEEQNLSTPLGPNFGGYHTDLPTLCLRMSVDRTTLANTTTYGRDAVFHLLCPAFQPVVIEQKIVFHDTLFPLVITGQQHRGFKFVWFFIPTIPDGMTLRYIVVLEDKIPLSVKTGAIGFYGGGLGAFGCAIAATAFPPCAPVALSLGVGLAPFGFGSGAFSFLSTLHLMATTPGSQTLGDPIFFQPDNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBG0</accession>
    <name>A0A132BBG0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_711051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064117.1">
        <property type="nucleotide sequence ID" value="XM_018217880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBG0"/>
    <dbReference type="FunCoup" id="A0A132BBG0">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="28827606"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711051"/>
    <dbReference type="InParanoid" id="A0A132BBG0"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="410" mass="44850" checksum="418212E1106EDD73" modified="2016-05-11" version="1">MSEVQDQSVGSQTRLTNHAEKELDIIIQSPERENDGDSNSKDKDQEPINRDAQEGVQYMEAVASVWTKTSLITAYGTAIGTLTPFVTSTFGKHSLTPTVTVLASIILDIWGRHTGIVISIVLTEMGFIMMAACRSIDQYAAAEIFWQVGHSCLLYTVQIIIADAPSLKSRGLMVAYAGSPSLITTWAAGPISQAFLHGPGWPWAFGTFAILTPIVVLPLIVLFQRTPFQYILHYLREFDAVGLLLLTAGLAMFLLPFSIHTYQRDGWRSPLIICLLVFGFALVFVFVAWESRPYVNLFLGLPLTILALGLTYYFSAPGWHCGYFIFTQIMLSIGHAFIILCDEVAAMSAVSHQYVAVVLAMEGLSSSIGGAISSTLSAAIWTSVFPKALAKHLPAKDLPDLEKIYGSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCD5</accession>
    <name>A0A132BCD5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_598083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063672.1">
        <property type="nucleotide sequence ID" value="XM_018210016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCD5"/>
    <dbReference type="FunCoup" id="A0A132BCD5">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCD5"/>
    <dbReference type="GeneID" id="28819742"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598083"/>
    <dbReference type="InParanoid" id="A0A132BCD5"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ09317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="442" mass="49568" checksum="8C9815E4FEB8E025" modified="2016-05-11" version="1">MESTTHIKFENSPADSLADSFVSTPGTAYPPLFDDDMEPLDAMTPQSYDDDNFRGSMDPSVAGTPAPEKKPVKKRKSWGQQLPEPKTNLPPRKRAKTEDEKEQRRVERVLRNRRAAQSSRERKRQEVEKLEAEKMAVERKAKDLELRLADMEAKNAHLQRQLEQMKGGNMSVFASSPAASSPIAELRQSSPVTFTTTIFGQQEIESRPISTQALPQPVKTVNPASLSPEIRPVAESSNANSSDLTQHPAAMFHTPDADRQFLENELPAIANQFNSEFDNMAHYNEGVFDNFTFDEYINNDDQPAPETQRLLACSPNLARPLKDATMVAMRLASEQQLSNCFSSVGPSRHELGSSPSVEALMTLLWAIHVIEKERENTLPKLDVAIDEEQEAEFAFRPSTIKRREREVSYVKHGRRGPMAGSGRSKKSLGDWRPAFDGRPHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCX8</accession>
    <name>A0A132BCX8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_596184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064611.1">
        <property type="nucleotide sequence ID" value="XM_018209905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCX8"/>
    <dbReference type="FunCoup" id="A0A132BCX8">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCX8"/>
    <dbReference type="GeneID" id="28819631"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596184"/>
    <dbReference type="InParanoid" id="A0A132BCX8"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000121">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1260" mass="137698" checksum="5483D1F072C5845F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEN9</accession>
    <name>A0A132BEN9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_270937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064502.1">
        <property type="nucleotide sequence ID" value="XM_018206364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEN9"/>
    <dbReference type="STRING" id="149040.A0A132BEN9"/>
    <dbReference type="GeneID" id="28816090"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_270937"/>
    <dbReference type="InParanoid" id="A0A132BEN9"/>
    <dbReference type="OrthoDB" id="5426988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25086" checksum="DF1CA4F2F54BF8B4" modified="2016-05-11" version="1">MSTVGCEIDSKKNNRRSFSPSCILLLNGFPGVGKLTIAKALQIRLRHNNAPHRLIDNHLLIDPVVTIEPERNTAHYFLRKSFRRTAFERLKALKEEELVLIFTACLVTSRVPTAYDDIEQFGEYVDFAEAKGVPLVMFNIVCDLSANCGRLYSEERRKGAVGGKTKLVNIEVLEKIRQETSLLAREQVMACKKGVNIVYFEVDTSDLAAGDAAEKVWDLLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRR8</accession>
    <name>A0A194WRR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA mismatch repair protein msh-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_787089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065043.1">
        <property type="nucleotide sequence ID" value="XM_018223040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRR8"/>
    <dbReference type="FunCoup" id="A0A194WRR8">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRR8"/>
    <dbReference type="GeneID" id="28832766"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787089"/>
    <dbReference type="InParanoid" id="A0A194WRR8"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA repair protein MutS, domain III"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="916" mass="103038" checksum="947339653DFB328B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT81</accession>
    <name>A0A194WT81_MOLSC</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_238762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206078.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_238762"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12349" checksum="26758C0F7D334153" modified="2016-10-05" version="1">MTTSSFMGLPVEMRLQIWNYILKIPRVVTIDYDPNSEDFTRAKLHQTTPVLLHVCRESRALAFPRYGSVFTPTNGREYTGCRGLNVIERLLHLLTIDGPATAREKRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTE9</accession>
    <name>A0A194WTE9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic dynein-like protein 1 intermediate chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_625739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065585.1">
        <property type="nucleotide sequence ID" value="XM_018211085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTE9"/>
    <dbReference type="STRING" id="149040.A0A194WTE9"/>
    <dbReference type="GeneID" id="28820811"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_625739"/>
    <dbReference type="InParanoid" id="A0A194WTE9"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000425">
        <property type="entry name" value="Cytoplasmic dynein 1 intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="704" mass="76969" checksum="D7C503C60EF6BD2B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTM2</accession>
    <name>A0A194WTM2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_674637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065661.1">
        <property type="nucleotide sequence ID" value="XM_018213452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTM2"/>
    <dbReference type="GeneID" id="28823178"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674637"/>
    <dbReference type="InParanoid" id="A0A194WTM2"/>
    <dbReference type="OrthoDB" id="3559627at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="38297" checksum="74C32110B7AF0610" modified="2016-10-05" version="1">MDIADSNISTRKNGCNAWDDEFQAQETERPGAEMNSKQPNFVWSQESSDNLVAAQANANTLPSLPNTRAPPCATTFDSSINHLLTRPLPEIEISDRNIILAELSSLQSRCATLQRLVAGASSPVKQCQCGHGAHQCCVATGTLAPTLPNLSDDDNGSNLIASRLYLPGEELDTGDDGGAPDLFSRGYSRLVPSSFDVVSTESAFQTEDLVQQDYNLFNASIYNTMEADFQDLFDFSAASIQSPQQVDGASALNTTTTFAGGAHNAATISNISATQPANAVVSRVSNNNQRPYNCPHPQCTLAFRRRGDRDHHALSHNPNAPRFSCTYPGCSRVGRRGFLRRDKLAQHQAHMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTN1</accession>
    <name>A0A194WTN1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_786695</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065394.1">
        <property type="nucleotide sequence ID" value="XM_018223011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTN1"/>
    <dbReference type="FunCoup" id="A0A194WTN1">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WTN1"/>
    <dbReference type="GeneID" id="28832737"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786695"/>
    <dbReference type="InParanoid" id="A0A194WTN1"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="270" mass="29967" checksum="4E4D1DBDE7667B1E" modified="2016-10-05" version="1">MASDISAQAAAPPSSENAFPSHRLTLRQRYPEKTPLVLVACGSFSPITYLHLRMFEMASDYARFNTEFEIMGGYLSPVGDAYKKAGLAAATHRLRMCELAVESSEFIMVDHWEAKNSSYIPTALVLDHFNHEINEVLGGAEKPDGTRVPIRIVLLAGADLVQTMSTPGVWSIDDLDHILKVYGAFIVERQGTDIDDALSSLEAYRNNIYVIKQIIQNDVSSTKIRLFLRRELSIRYLVPSAVVEYIEANDLYKAEGVPQIEDKGKGKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU78</accession>
    <name>A0A194WU78_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_654157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065870.1">
        <property type="nucleotide sequence ID" value="XM_018212283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU78"/>
    <dbReference type="STRING" id="149040.A0A194WU78"/>
    <dbReference type="GeneID" id="28822009"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654157"/>
    <dbReference type="InParanoid" id="A0A194WU78"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267520" evidence="2">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="31726" checksum="4BFA70420F44E318" modified="2016-10-05" version="1">MFFRTLAFAAAVGSAVAQRPANMSICDYYTTALLTNNTAANQATLLTLVVNTAVIGNYTQPNVGVSVPGILAPGEVNGIAVNLLPYFDGGFASTNTGGSAGMAVNFLDGGGAAPLMKNMPANDNTSAQYILLTHLYEYFGVLLGCSMQGGAAYPAYAGHASMYSVHKFMDLSYAEVTYFIDQVALSAMSFGVAKDDLTAVGTALTTLFGYRCEPPMTVVPSQGPQLESICIDSTCPLAANATCSSYATAMKPAIANSTLVPNSTTTSGGNASTTSGTSTSTSSMPATISKAAAATVGMSFAAVAGGLAALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUX5</accession>
    <name>A0A194WUX5_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_594722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066110.1">
        <property type="nucleotide sequence ID" value="XM_018209818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUX5"/>
    <dbReference type="FunCoup" id="A0A194WUX5">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WUX5"/>
    <dbReference type="GeneID" id="28819544"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594722"/>
    <dbReference type="InParanoid" id="A0A194WUX5"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="27761" checksum="187BE4C6A6CF5F06" modified="2016-10-05" version="1">MAARCVARSCPRLSTSTSPSAAQAFMQLAPRRHLYNAPPVLDFLIPNVLLAALHHGWATKTVSKGRPPQNRAFTSSTRHQQTTAIFNPRKDDDGNDMNIEITPRAANRLKEIMNKDSNSNLALRITVESGGCHGFQYLMSLTTLPSPLQLSNSVEEEATLALNTSSSDPNAMPSGSPGPDTRSKHTKDEKDAKLGEDDIVFEADGAMVVMDQPSLELLKDSKVDFTMELIGSQFKIVDNPLATSSCGCGTSFDIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW76</accession>
    <name>A0A194WW76_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_786346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066583.1">
        <property type="nucleotide sequence ID" value="XM_018222976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW76"/>
    <dbReference type="GeneID" id="28832702"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786346"/>
    <dbReference type="InParanoid" id="A0A194WW76"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443852" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="60101" checksum="97FD6CF1C351E879" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWQ7</accession>
    <name>A0A194WWQ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF453-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066763.1">
        <property type="nucleotide sequence ID" value="XM_018220346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWQ7"/>
    <dbReference type="STRING" id="149040.A0A194WWQ7"/>
    <dbReference type="GeneID" id="28830072"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738198"/>
    <dbReference type="InParanoid" id="A0A194WWQ7"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="383" mass="40497" checksum="6F64E5189D819856" modified="2016-10-05" version="1">MQYRIVSTASERLKRAPAAYYRGGTSRAIMFKQEDLPPDRKDWAPIFLGAIGSPDSNGRQLDGMGGGLSSLSKICVIGKCADSEIADVDYTFAAIGIKDTDVDYSSNCGNMTSAVGPFAIDSGLVESPSDGDTTIRIRNTNTNKIIHSTFPVVDGEAEAHGDFAIDGVSGTASRIQLAFINPAGSRTGKLLPTSNSTDIIDDVKVSLVDCGNPCCFVSAEELGVDGTTLPDAIEKQPELLRILDSIRRQASVLMGLSKDAASATGSVPKIAMVSRPSTHQILSGDNMDKEEVDLVVRAISVGQPHRAVPITVAMAIAAAAKVEGSVVQQLAEKGRNADRDGFTLGHSSGKIVVGANFAGDGTLKDVIVYRTARRLMDGMVYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWW0</accession>
    <name>A0A194WWW0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_224048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066529.1">
        <property type="nucleotide sequence ID" value="XM_018205973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWW0"/>
    <dbReference type="GeneID" id="28815699"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_224048"/>
    <dbReference type="InParanoid" id="A0A194WWW0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="20824" checksum="54894ABAC72A154B" modified="2016-10-05" version="1">MFATLLLLDCSHESNSCQFRHRNAQASVESHASGQQERGGNDLTLTDLHEQVLGRLLNCKRCGLSRQGRERGHQDDLLPWCGIISPNPTGHGPVQMVSGYNTFIMQFLSDSTLSFSPAFHVQGQRLGKHTFKLHKKFYLNGKCCMHLTFRDAIYSYHGGQIRGYWSSGPRVIVIRSHLCKPLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXM3</accession>
    <name>A0A194WXM3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_205879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066692.1">
        <property type="nucleotide sequence ID" value="XM_018205819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXM3"/>
    <dbReference type="STRING" id="149040.A0A194WXM3"/>
    <dbReference type="GeneID" id="28815545"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_205879"/>
    <dbReference type="InParanoid" id="A0A194WXM3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="378" mass="42828" checksum="B73CC329D64FEAB3" modified="2016-10-05" version="1">MTANMSNGIHPRYVPRDQKEAQTLASSIQVLRVSDNKPFLAAKIPSMLCKDAIETDDEGEPTITTNLASALLPVAALPISRILNHPNIISLVDIVHKSGEEGSNQNFGAFSDITIWEDMNAGSLAYLLPPVNNYPTFSDETAWHNLAAQNFRRFSLPESLCWHVLKSMCRALLWLHFGIKETPGIPGEYRPHDDDWQPILIMDVSPPQIWFKRARFGEMYGECKLGGFQWAKVTGMIGGRMAMANIRYDAPRRNQYYWAPEIYRNTNSWSRPSEIWSLGATIYTMMTGIPPPRFHDWNWQVSRMCDKGFSQPLREIVGAMLKHHPADRPTALDLVNKVNTEWKIWRSNSVEGRRVVDVDDKIKLKMSLGPGVGQMGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY04</accession>
    <name>A0A194WY04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_709402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067211.1">
        <property type="nucleotide sequence ID" value="XM_018217754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY04"/>
    <dbReference type="STRING" id="149040.A0A194WY04"/>
    <dbReference type="GeneID" id="28827480"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709402"/>
    <dbReference type="InParanoid" id="A0A194WY04"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="30160" checksum="965A9EE84F4C0C18" modified="2016-10-05" version="1">MRLINTETMKMEEFFNENVPPYAILSHRWGAEEVSLQEWNRIQAIETKMDTLLQKAGFAKIISFIEATKQVRYVWADTCCIDKTNNAELSEAINSMFRWYQEAEICYVYLADVPTGLTESELEEHICASKWFERGWTFQELLAPHVVMFYDQRWDFLFEKRDRCSLLSRITRIHDTFLSESRRIGEACTAMKMSWAATRTTTRDEDLAYCLLGIFDVSMPPLYGEGKKAFVRLQEEILRHSGDLSIFAWGLLTLLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ09</accession>
    <name>A0A194WZ09_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_154016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067546.1">
        <property type="nucleotide sequence ID" value="XM_018205439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ09"/>
    <dbReference type="GeneID" id="28815165"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_154016"/>
    <dbReference type="InParanoid" id="A0A194WZ09"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267625" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
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    </evidence>
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</entry>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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            <begin position="75"/>
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        <source>
            <dbReference type="EMBL" id="KUJ12917.1"/>
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            <dbReference type="Proteomes" id="UP000070700"/>
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            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="545" mass="61151" checksum="BE9BC9337E77FEA0" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 120377</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Mollisia scopiformis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
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        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
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    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
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    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
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        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
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        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01866">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="446" mass="49316" checksum="B6E2BE9CA7FA5C74" modified="2016-10-05" version="1">MEEDRAEVDLGIAVDVEERQEAEAQRLPKRRFVGRRQVAEAASNAEANGSTENRGTIQVSKSRRTPRTLNQVPPEILNDPEINAAIALLPPNYSFEIHKTIHRIRTNGSKKVALQMPEGLLLFATTISDILTQFCPGVETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTTIKTLYVFVDISIDTAHLLSTLEKNFSTGKTIAMVGTIQFNATLHGVRAPLEKAGYNVLIPQISPLSKGEILGCTSPRLDSTDGVDIILYLGDGRFHLESAMIHNPSIPAYRYDPYSRKLTRENYDHKEMHTLRREAISAAKSAKKWGLILGSLGRQGNPHTMSMIEQKLEGQGIPYVNLLLSEIFPGKLAMMDDIECWVQVACPRLSIDWGYAFPRPLLTPYEALIVLGANEDWDKGNGGIYPMDYYGKEGLGRTKDARLIAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X014</accession>
    <name>A0A194X014_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_541454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X014"/>
    <dbReference type="GeneID" id="28817908"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541454"/>
    <dbReference type="InParanoid" id="A0A194X014"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29463" checksum="755F175FFE680E1E" modified="2016-10-05" version="1" fragment="single">LLSPDYVPLVVTNADIKLASVAWGFTLGVGALTCWKALKQTQRVVATKRFRSAYVWMIWGEILACLTFSIICWLHLNGNIPPSFGFYFAILTCWSLQVQLLLQIIINRIAIIDNNVQRIRTLKYSVAAIVTAINISVYCIWIPARLQISPEYIRINSIWDRCEKVLYLVVDASLNWKFIYTVQKNLVRMGLEKYRSLMHVNIAIVLLSLSMDVLIIGMMSLKNTFVYCQFHPLAYIVKLHIELHLAELIASIAQRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0B5</accession>
    <name>A0A194X0B5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_720883</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067991.1">
        <property type="nucleotide sequence ID" value="XM_018218599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0B5"/>
    <dbReference type="GeneID" id="28828325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_720883"/>
    <dbReference type="InParanoid" id="A0A194X0B5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="158" mass="17465" checksum="470EDC5C57F638BD" modified="2016-10-05" version="1" fragment="single">MSNFIHHVVSSHSGVSTNQSPPVNWAHDDLTSRFNLVIGEVEKIYGDDFPRQRRDDMLFWNVLGAIEIEERKARVDANLRGTASTGIKVESTGIKTEAEEVSTSGPSNTRRVKIDEEERKYQPVSISPPAQNSTRREHASGRGMPAAAHSAGRGRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0M2</accession>
    <name>A0A194X0M2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068103.1">
        <property type="nucleotide sequence ID" value="XM_018215432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0M2"/>
    <dbReference type="GeneID" id="28825158"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687123"/>
    <dbReference type="InParanoid" id="A0A194X0M2"/>
    <dbReference type="OrthoDB" id="3000060at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="596" mass="66541" checksum="458128AAC528B325" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1U1</accession>
    <name>A0A194X1U1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_687163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068162.1">
        <property type="nucleotide sequence ID" value="XM_018215443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1U1"/>
    <dbReference type="GeneID" id="28825169"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687163"/>
    <dbReference type="InParanoid" id="A0A194X1U1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33648" checksum="1D377869037F29AB" modified="2016-10-05" version="1">MADIEATIEYLEDLELYDNVKPYWCSLPPRDGFDPDKERLDNLEFESRKIQIHDMRFLKDKPRIDVNGFQVFDHTTQISRFEAPEDVARYKSETEELHLKNLGAVYVKCYDMALRTNILFDRTEYDLNDPLHTEGPVRGAHNDISRNFGPQMINKHLPDREKELYMRPGYRFRIINTWRSLLPIVEDRPLALCDSRSVAAADLISCDRIVPEHIGEVYFLKHNSNHKWYWLSRQKDSEPFAFVMYDTKAGPHARFCPHVSFDNPQSSREAPPRESVETRSLVITRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3A8</accession>
    <name>A0A194X3A8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068662.1">
        <property type="nucleotide sequence ID" value="XM_018213231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3A8"/>
    <dbReference type="GeneID" id="28822957"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671672"/>
    <dbReference type="InParanoid" id="A0A194X3A8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="222" mass="24044" checksum="20EF035D5E1268E2" modified="2016-10-05" version="1">MESSSPAPFKAFEKGTAADRIPSFLPNNMQHGGLPNETHSALQTHTVVSKDEVIPSGNSNDSNQKKDGHVRNRKYKKDSKHQATYSLGHSIMLPSMINTATGTGYTHHFQPFIATSQSTKIVEIVPVSTLTSDQDSGAFTLAHDHLEGTKPITKLEGIDRSLEVNTNNHIPESFYVISPSIGDDSMMEEILLGIGSQFEACSSVSSINADDLLAMKGTLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3L2</accession>
    <name>A0A194X3L2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_686417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069111.1">
        <property type="nucleotide sequence ID" value="XM_018215280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3L2"/>
    <dbReference type="FunCoup" id="A0A194X3L2">
        <property type="interactions" value="1073"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3L2"/>
    <dbReference type="GeneID" id="28825006"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686417"/>
    <dbReference type="InParanoid" id="A0A194X3L2"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="59168" checksum="D0BA7B6AECFB8AFD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3V5</accession>
    <name>A0A194X3V5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">LY89DRAFT_783932</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069220.1">
        <property type="nucleotide sequence ID" value="XM_018222736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3V5"/>
    <dbReference type="FunCoup" id="A0A194X3V5">
        <property type="interactions" value="1009"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X3V5"/>
    <dbReference type="GeneID" id="28832462"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783932"/>
    <dbReference type="InParanoid" id="A0A194X3V5"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6N4</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
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                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
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    <dbReference type="OrthoDB" id="3557544at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="30406" checksum="5C7B614EC4A01745" modified="2016-10-05" version="1">MSANLSSSAPTTAAIPKLNATITKSSSSRISSNDSNSNIASATELTFSSSQTSPISSKNVTSATELTPGSSYIDSSTSTTFGESNSITELASSSSQINSYSSNSSTSFIPTTATDASFIQTGMTTSSNSFSVAWTTPTSFSTVTVSRNSSSTGPISSLLSSSIWIPGTGMLPFPTTTGSSLSQAPLTFSGTWTDLSTTAASFVWFDIPTATIADTTATSEAALLGNLFFALQANRHLLTDPKLKSQFLDDVEKTKDEALALFNDLDVKIPSQIVQTQERERGMRYQRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X759</accession>
    <name>A0A194X759_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_587373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070002.1">
        <property type="nucleotide sequence ID" value="XM_018209426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X759"/>
    <dbReference type="GeneID" id="28819152"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587373"/>
    <dbReference type="InParanoid" id="A0A194X759"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ15647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="443" mass="49832" checksum="5408C2F966D2B273" modified="2016-10-05" version="1">MKYGETFQAQSVPQWAPYNVDYNELKNLIKVHTTKDQAQAIAIPGQADSHLERFEALFFNELSNQHDRVDLFVKSKADEVHRRLQYLQKLVVKLLARCADSAAIGKPMSSKRREKFARYDIQIERCGEDIRSLQRFTAAQRMAFHKILKKYKKWTGSRALGERFNDEILGNPKSFVRRDFEPLSSEYTSLINTLRASSPDGSGPETPSISRRGSRRQSTQIQTQPQTPQGYWNEYDHGSEVEGNESYTIYINPDEESFPGSKTFAYVFAEVKKPFGKVKEWLSPKSSPGERQPLITNGNESYFNEQRSTIDTDDDGAYASSSDFPTGYAAHYATFPSVRDQKHSQAREMLLNQTMFGSFGASLLFLLIAAILVATGKKKLRVEVDAGVIVGIVASLCFNMAAIGAVLGRQQDLGWLRRSLIAVTFVSICIFNGMLLVIVASTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7T8</accession>
    <name>A0A194X7T8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070232.1">
        <property type="nucleotide sequence ID" value="XM_018215147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7T8"/>
    <dbReference type="GeneID" id="28824873"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685779"/>
    <dbReference type="InParanoid" id="A0A194X7T8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="110" mass="12758" checksum="0394BD930564E18E" modified="2016-10-05" version="1">MMKKIRFQEATEYAHLLKWAGGNAPAFKLISLAPPAPPGKVYEVLHLHHHEVRALVRKNHALMREFESQTNCKITISREWKLQPDKEIGLFGYRENVEEAKKVILGRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X853</accession>
    <name>A0A194X853_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_554124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070649.1">
        <property type="nucleotide sequence ID" value="XM_018208343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X853"/>
    <dbReference type="GeneID" id="28818069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_554124"/>
    <dbReference type="InParanoid" id="A0A194X853"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="31062" checksum="D196A1A940A58A1F" modified="2016-10-05" version="1" fragment="single">MLPTSLAGSYQQYKQDTTVFTTWLSKAAIACGYEIPSEHLQKPTPTAQTKAQTPSKRLKGKARKEAAEIPKVETGKPDTRPIIRYVVPTKELIKQAEVVAKQGKRVLPQGLRRVANRAIDARRRCADWFRTSKVKNEHSDEAIQLVRQNEEEILASAPNLFNKKRSYNTIAIVIFYANAFSEGYDPAEKMRSNDSLKPTPFDDFIYLSTARILMKMDFFSKMPDNIAYPAPIWPLRMSFISRPELLAMPYIKHKEKEDVILSQHIIDHDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8N5</accession>
    <name>A0A194X8N5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070886.1">
        <property type="nucleotide sequence ID" value="XM_018215094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8N5"/>
    <dbReference type="GeneID" id="28824820"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685477"/>
    <dbReference type="InParanoid" id="A0A194X8N5"/>
    <dbReference type="OrthoDB" id="5399817at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13402" checksum="606B4E92ED8A7033" modified="2016-10-05" version="1">MPSTASKFFFFYAAITAAGTVLGHTQMGYNLVFPALKKAPNSPGVKAARIGWMECNQGFAFIALFCIKWANHGLTSYYDKIFFAIYTVAQIWTGIAYLRAGIYQPLVLLWGIPALVGIALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X998</accession>
    <name>A0A194X998_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_733752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071100.1">
        <property type="nucleotide sequence ID" value="XM_018219841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X998"/>
    <dbReference type="GeneID" id="28829567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733752"/>
    <dbReference type="InParanoid" id="A0A194X998"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267994" evidence="8">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="119" mass="12959" checksum="1C5F693F48596A8F" modified="2016-10-05" version="1">MIIGFGLLTLLNASSSTGAWMVYQSMIAAGSSTILSSILPAIQTSLSDEDPAASTALFAFIRSFGAIWGIAIPVAVFNNQFHRLLYLIQGPAEGPPWRMDKHMIMLRAYLLTHFGNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9D3</accession>
    <name>A0A194X9D3_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_718534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071135.1">
        <property type="nucleotide sequence ID" value="XM_018218421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9D3"/>
    <dbReference type="GeneID" id="28828147"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718534"/>
    <dbReference type="InParanoid" id="A0A194X9D3"/>
    <dbReference type="OrthoDB" id="3508416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="36091" checksum="CEA884ADE3CAD3D0" modified="2016-10-05" version="1">MERNSVDLRSDGTGPYNDQSNPQLNNRDTMATVRDPDRPQIHHPSDLEGAIRLVENTLIRQKQDRVALCAHIASTQTTNSTVASTSTITTIATLSVLNAAQTMPGEIPKSAAVGPASSPRAHPNHAMQRRPIRHREFRSSHMLLQFRGQARRDESQLPLGPIILGISTPMDFFLKSTDFQLEGTVRALDVKAPTGGYTTFAFSLSFNTPEAALAFWNRANNGNVLLIGGNVVRVAADRVGVRRLDTIETRVLIIDGPSYLVNWPYLKAQFDDACYYNLDRWFMSQSPTPGMVRMEVRFARVVGQAQSCKQKCDWNPAHRNVLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA37</accession>
    <name>A0A194XA37_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_70222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071386.1">
        <property type="nucleotide sequence ID" value="XM_018217240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA37"/>
    <dbReference type="GeneID" id="28826966"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_70222"/>
    <dbReference type="InParanoid" id="A0A194XA37"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="23392" checksum="C25AAD84B83BC554" modified="2016-10-05" version="1">MDERRRPHKKEGANASSSSPEPTRVKSKSKPQRKKGVERQQVATSGPVFRDRVLSKRITKPVTVKKSSQRGRRRLGGSDANIETSAQPARAGSRSTEILGSEVPSDAIAKNTRRSTKLKAIAESSATGVDDDMGAQQDDTDFMALTDRETLLSKEIHELKQRCEKQKVRIAATRIALHAQQTELQQIQLSLENTRGEYNTVQTNLQQLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAS1</accession>
    <name>A0A194XAS1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_782408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071594.1">
        <property type="nucleotide sequence ID" value="XM_018222576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAS1"/>
    <dbReference type="GeneID" id="28832302"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782408"/>
    <dbReference type="InParanoid" id="A0A194XAS1"/>
    <dbReference type="OrthoDB" id="3438781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268075" evidence="2">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="32030" checksum="3280B5116F42BDCC" modified="2016-10-05" version="1">MPSLFLQILLLAIAEFTTASPDASGSCDSGFTICAPPGASSAITPQIGSPDFQNLFVDIIQSSLPASKRSLPHFVRSSTSLCCNAHLSCLMMATLALPFCYDKFTTNFFLPDGSTGTVVGGAYKSAGGDVANLETGDYTLVDGQTGNIYSANPAAKPNTATLPMPSQFTASGVGSAIPIASLGSEIILTYTTTLPGTTILASTLPPSTAPGTTSTETIPLPTTTTISATGTSPSLTVGVVTSYSVVDVSPSTIPGSTLSGSTIAATVATITTTEFSALPASSTPSASTTKKNGGTRVSMNDRRCWVIGIVLLLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB08</accession>
    <name>A0A194XB08_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_781572</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071713.1">
        <property type="nucleotide sequence ID" value="XM_018222489.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XB08">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XB08"/>
    <dbReference type="GeneID" id="28832215"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781572"/>
    <dbReference type="InParanoid" id="A0A194XB08"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="440"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="676"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="879"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KUJ17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1357" mass="148859" checksum="E3049577EA3D78A6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBI1</accession>
    <name>A0A194XBI1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_72407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071472.1">
        <property type="nucleotide sequence ID" value="XM_018218868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBI1"/>
    <dbReference type="STRING" id="149040.A0A194XBI1"/>
    <dbReference type="GeneID" id="28828594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_72407"/>
    <dbReference type="InParanoid" id="A0A194XBI1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    <sequence length="690" mass="75683" checksum="0C035FF93B90262D" modified="2016-10-05" version="1"> </sequence>
</entry>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
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        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51186" checksum="FE27FFF0E0C0EE83" modified="2016-10-05" version="1">MLSEKRNSYSKMVAKAEPEVKERKPKRRVKRKVSELDPIAAKKRREQTRVAQRAFRRRQEEAIETLGKEVDHLNGIIEGLNNTFVSFTDVLAKSKWLEMDACMASELKSTIQTFLELTQSSPEPISRGEAAAPLHSASKHAAPNIVPENLTSPSSSSSPRPTNHEKIRGYSGSAIGSATSSSPQGRSTESTSAFGPTNTSSNFSSILSPSFSIPSPYLSLSAIQSMSWQTLPTNEVSFAGRLHRAAYEEGHRILCNWDRELYSYQQVFSYMLGAHTRDSLFWYLSKALNENLHGVLDPPEQLFPLADVTFQTNSWLNATEVYQYFRMNGIDFDDYPVLAKVEIAVDNAYDDVANNENTLDFSLTGPTVNLKTQTSNYSESFDFSTLISSHNRYQFGSDPKIVSRPAAVPLTRRVSVDVAKLISEIVLPSQTQCRGRNPVFRKQDLHRAMKRSVVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCT3</accession>
    <name>A0A194XCT3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_781079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072316.1">
        <property type="nucleotide sequence ID" value="XM_018222446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28832172"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781079"/>
    <dbReference type="InParanoid" id="A0A194XCT3"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1434"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1587" mass="174607" checksum="341A68C2E95E6B42" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCV8</accession>
    <name>A0A194XCV8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_35296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072365.1">
        <property type="nucleotide sequence ID" value="XM_018206943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCV8"/>
    <dbReference type="GeneID" id="28816669"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_35296"/>
    <dbReference type="InParanoid" id="A0A194XCV8"/>
    <dbReference type="OrthoDB" id="4220372at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="561" mass="63676" checksum="6BDF78B8C73E5869" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD45</accession>
    <name>A0A194XD45_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_583572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072434.1">
        <property type="nucleotide sequence ID" value="XM_018209221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD45"/>
    <dbReference type="GeneID" id="28818947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583572"/>
    <dbReference type="InParanoid" id="A0A194XD45"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="28330" checksum="BC20AC65DF36BC03" modified="2016-10-05" version="1">MTANIDTILLLGATSGIGEAFARYFHGKGKRVIAAGRRLERLDALKSELKGLETFQMDVEDIPAIEPKLNELFKTYPDLDSVFVIAGIMTMGQFKDPSTTSTKGIVSEVTTNLIAPMVIARTVVPHLLSLKRPTTFITVTSGLAYMPLPFFPVYNATKAGVHNFTVVLRTQLTGTNVNVIEVAPPYVATDLDVKFREEQNKMQGGKGHPPMPLKEYMDVTTKQLEEGKDKELATGFSAMGVSAWRGAFQPLLDQFGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEB9</accession>
    <name>A0A194XEB9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_732799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
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    </reference>
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            <begin position="124"/>
            <end position="146"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
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        <source>
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    <sequence length="239" mass="25566" checksum="CDD4BE83D5704EEB" modified="2016-10-05" version="1">MAVLFRRATTIPSTSAAFTTITTAVLTYTMPEALAVYSPSSTKPWSTIIRLTTVTSSATLTYSEQFIPVATEISAVTTTSILTVLNLITSVPASSISSTASSTTSPTPSAIAKVSPGLASGAKAHIAVGVIAFVFLLIVVFVSLALRKRKRRQKRAGGRSQDPDTHEMATRHNVPEMDEQNKGRGLHTMIVPDIVSSSSNAGSDELYEALGSTIWEQEISSPNKGQWDPRLQALKELEE</sequence>
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<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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                <person name="Mondo S.J."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16 17">CBS 120377</strain>
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    </reference>
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        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2506" mass="276417" checksum="98ED823C00B1EF99" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG18</accession>
    <name>A0A194XG18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_731509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073441.1">
        <property type="nucleotide sequence ID" value="XM_018219579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG18"/>
    <dbReference type="GeneID" id="28829305"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731509"/>
    <dbReference type="InParanoid" id="A0A194XG18"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF7">
        <property type="entry name" value="MEMBRANE ANCHOR OPY2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="83537" checksum="4057BD48E4134906" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGX0</accession>
    <name>A0A194XGX0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_780332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073741.1">
        <property type="nucleotide sequence ID" value="XM_018222370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGX0"/>
    <dbReference type="GeneID" id="28832096"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780332"/>
    <dbReference type="InParanoid" id="A0A194XGX0"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19669" checksum="8A1F0C316AC0267D" modified="2016-10-05" version="1">MANQTRLPEISHYITSYDPSGKSTFLAAPNPPLVQMNDPSMRVDYIYSTVGSATGPVLTDLVDYKNNQDVRNTTPHIMFPLAGGSSAVVASFEPNPDPDNDTGFMHRSNTLDYVFIIDGELELTLDSGEKRVMKRGDVCVQRASQHSWKNLSKTEIARFGAVTLGIEGAKLNEMIFPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHE9</accession>
    <name>A0A194XHE9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding WSC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_545142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073943.1">
        <property type="nucleotide sequence ID" value="XM_018208231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHE9"/>
    <dbReference type="STRING" id="149040.A0A194XHE9"/>
    <dbReference type="GeneID" id="28817957"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_545142"/>
    <dbReference type="InParanoid" id="A0A194XHE9"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10212" checksum="5AA1A1919759ABB1" modified="2016-10-05" version="1" fragment="single">VQTSGVYTYLGCYTEGAGMRALQGEFFPDDSNTVERCTANCYPFQYAGLEYGRECWCGDTIEGGASSVQNLQCGMACAGNSGEICGDSNRLSIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI91</accession>
    <name>A0A194XI91_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetratricopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_666723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074233.1">
        <property type="nucleotide sequence ID" value="XM_018212932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI91"/>
    <dbReference type="STRING" id="149040.A0A194XI91"/>
    <dbReference type="GeneID" id="28822658"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666723"/>
    <dbReference type="InParanoid" id="A0A194XI91"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="443"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="532" mass="60212" checksum="D3D99F8B268B2021" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIA2</accession>
    <name>A0A194XIA2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_641170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="KQ947410">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074209.1">
        <property type="nucleotide sequence ID" value="XM_018211702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIA2"/>
    <dbReference type="FunCoup" id="A0A194XIA2">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIA2"/>
    <dbReference type="GeneID" id="28821428"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_641170"/>
    <dbReference type="InParanoid" id="A0A194XIA2"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="473"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="536" mass="58858" checksum="92553866B624F669" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJB6</accession>
    <name>A0A194XJB6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_474394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074569.1">
        <property type="nucleotide sequence ID" value="XM_018207795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJB6"/>
    <dbReference type="GeneID" id="28817521"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_474394"/>
    <dbReference type="InParanoid" id="A0A194XJB6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="219" mass="24311" checksum="B8D60AB05485FAF8" modified="2016-10-05" version="1">MGNALGIFGSLRSIRASASAQRSPGEAVECDIWAARVQKMMMHRTKEGFTDAKSTPPPAWMAPILARGMQYCTWIWVRADLFQTDREAEVSVPAELVPVDPDPGPEELDAEKSSWGGSNRFLILFSFLFFFPSTFFLSLFLGSPLRIDKEEQRHVRRLYLSSTYLTYGTRSRIIALWLDPMAPTLTTTSPAMIAMRTGAAVAEVSPGRCGTDEKKKVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJD0</accession>
    <name>A0A194XJD0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_682705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074222.1">
        <property type="nucleotide sequence ID" value="XM_018214551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJD0"/>
    <dbReference type="STRING" id="149040.A0A194XJD0"/>
    <dbReference type="GeneID" id="28824277"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682705"/>
    <dbReference type="InParanoid" id="A0A194XJD0"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="22644" checksum="72EEB0FC459F443D" modified="2016-10-05" version="1">MAMEQRRPPEYIIEVYADPSSLKDVMRGILHTIFFHRFFPSIRPKTRDVLDLCLPFVEEPELETMIDQRTAALVRQLDTSSDMGMRSTGVRGLMAVQFFEKKRRKAWFTKGEEEICWEQWTLNITLATPRTESERAKVRKAMEAMLLKAAMRIVTTVNTHKDHIPPITTIDSNPFPYQIIINPKDNGWGARMGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJH8</accession>
    <name>A0A194XJH8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine-uridine preferring nucleoside hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_779070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074634.1">
        <property type="nucleotide sequence ID" value="XM_018222268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJH8"/>
    <dbReference type="STRING" id="149040.A0A194XJH8"/>
    <dbReference type="GeneID" id="28831994"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779070"/>
    <dbReference type="InParanoid" id="A0A194XJH8"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="454" mass="49658" checksum="F98BFD71C7444867" modified="2016-10-05" version="1">MAPLNRIIIDTDPGVDDVLAMLLALAAKPEELEVLLLSVTYGNVEVQSCLRNVVALFHVLEKEMEWRRARGQLEGFGCMTSSKPIVAVGADHPLEDEILMADYFHGVDGLAGVHTSHPHLSPSDAWKTLFQPPQANATTQQVAEARELATPITSFRASQVPAHKEILRLLKENPRDTITIVAVGPMTNLALAAAEDTETFLRVKEVVVMGGAIDVEGNITPVAEFNTYADAVATARVFALTSPTPSSTMPPPPLKISKLPPYPTKLSRQLKLTLFSLDLTTPHTLQRSHLMAKLDPLIKQGSPLAEWTSAFVNKTYEKIESLTRKQLDPGLELHDPLTIWYMLTREAPQWMGAPKGLEDIRVETAGQWTRGMHIIDRRNRKKGGAPEQIKSPGAVDIANPMEQLVIPNADGEGGDAPGDNGGWLAPHKGNRINRIVGSPGEEFFGPYLLERVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJM4</accession>
    <name>A0A194XJM4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_682795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074332.1">
        <property type="nucleotide sequence ID" value="XM_018214574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJM4"/>
    <dbReference type="STRING" id="149040.A0A194XJM4"/>
    <dbReference type="GeneID" id="28824300"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682795"/>
    <dbReference type="InParanoid" id="A0A194XJM4"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000007">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="11">
        <location>
            <begin position="75"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="10">
        <location>
            <begin position="263"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ19977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="63514" checksum="CF96441DD43A891D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJW5</accession>
    <name>A0A194XJW5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_730451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074759.1">
        <property type="nucleotide sequence ID" value="XM_018219480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJW5"/>
    <dbReference type="GeneID" id="28829206"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730451"/>
    <dbReference type="InParanoid" id="A0A194XJW5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="172" mass="18637" checksum="4BAEFF702C6F643A" modified="2016-10-05" version="1">MAQIAPISFTSPLQDDDTEIERAWWNLELQWVEEAEEDGYESSTLDGESDEGETDEDSDEWEDVSESGSEVQQQRNYKMSIQDLTTSPLDLSTITPIMAVQSELHLRGGSSGSDADDERDDTPDTESDDDFYGKYESTGSSSSGSGGSSGHYDVSDADSVASESTGPIYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK44</accession>
    <name>A0A194XK44_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_705917</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074517.1">
        <property type="nucleotide sequence ID" value="XM_018217486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK44"/>
    <dbReference type="FunCoup" id="A0A194XK44">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XK44"/>
    <dbReference type="GeneID" id="28827212"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705917"/>
    <dbReference type="InParanoid" id="A0A194XK44"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000045">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="14">
        <location>
            <begin position="434"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ20162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="859" mass="94541" checksum="6DD43599E798980E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKL5</accession>
    <name>A0A194XKL5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_578893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208972.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28818698"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578893"/>
    <dbReference type="InParanoid" id="A0A194XKL5"/>
    <dbReference type="OrthoDB" id="3553147at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF80">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14427" checksum="4833C2BA0DE15239" modified="2016-10-05" version="1" fragment="single">MSVPYNKLAERCIRLLDLYPGELNSPFRGRLRPTGLDIPEFYEALSYTWGSPETAAFLHCESGSLPLTLNLVQALLRLRRTDTIRTLWIDQICINQDDEIERGQQVGLMGGIYRGASIVDIWLGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL46</accession>
    <name>A0A194XL46_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_444918</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074852.1">
        <property type="nucleotide sequence ID" value="XM_018207576.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XL46">
        <property type="interactions" value="1241"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL46"/>
    <dbReference type="GeneID" id="28817302"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_444918"/>
    <dbReference type="InParanoid" id="A0A194XL46"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="14">
        <location>
            <begin position="507"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="13">
        <location>
            <begin position="694"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="12">
        <location>
            <begin position="897"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="10">
        <location>
            <begin position="1798"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ20497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2169" mass="243039" checksum="6904127839DC86DE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLU6</accession>
    <name>A0A194XLU6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COP9 signalosome complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_705058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075508.1">
        <property type="nucleotide sequence ID" value="XM_018217424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLU6"/>
    <dbReference type="STRING" id="149040.A0A194XLU6"/>
    <dbReference type="GeneID" id="28827150"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705058"/>
    <dbReference type="InParanoid" id="A0A194XLU6"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000022">
        <property type="entry name" value="COP9 signalosome complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="225"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="457" mass="51015" checksum="7E69B74676E1853D" modified="2016-10-05" version="1">MASSQGAPPSPTQSRSKKGLFVTEQPKLDLESYIANYTGRTRLERMILIGNCSAVLGIDAFKLAVREAKLGKDITKYLEAQTPLETIAPKEKEAARDLSWMDKTKSTNAAETARLESEVKGYKNNLIKESTRMGNEDLGKHFQAIGDLPKAFEAFSRMRQDAQTPKHIIDISRHLIEVAVEQRNWIAVTSNVQKIRGVMDSKDSDKAIPPFLCVAEGLSSLDSGEYLAAALSFLQTDSGMSSSANSIISPNDVAVYGGICALATMERAELTKNVLENSNFRTYLELEPHIRRAIGFFVNSRYAQCLSILESYRSDYLLDIHLQRHVDDLYQLIRSKSIVQYFIPFSCVTLDSLNEQFAAPGKTIEKELVQMIMRKELDARIDTVNRVLTSVPSAPRAALQSSVLKTAKDYEREAMRRIQHMNILAADVDIKSRNKLPGGDDFFDGGRELRSGRNTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLY2</accession>
    <name>A0A194XLY2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_681709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075449.1">
        <property type="nucleotide sequence ID" value="XM_018214355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLY2"/>
    <dbReference type="GeneID" id="28824081"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681709"/>
    <dbReference type="InParanoid" id="A0A194XLY2"/>
    <dbReference type="OrthoDB" id="3541192at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268438" evidence="7">
        <location>
            <begin position="20"/>
            <end position="545"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="370"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="56762" checksum="BBD91AEB7153F92D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLY9</accession>
    <name>A0A194XLY9_MOLSC</name>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_638949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211597.1"/>
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    <dbReference type="STRING" id="149040.A0A194XLY9"/>
    <dbReference type="GeneID" id="28821323"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_638949"/>
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    <dbReference type="OrthoDB" id="2119228at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="103"/>
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        <location>
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            <end position="230"/>
        </location>
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        </location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ21099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="243" mass="27342" checksum="0C3FE9044B243FB5" modified="2016-10-05" version="1">MGESRQELVQWLNQLLQLNITKVEQCGTGAALCQVFDSIYLDVPMSRVKFNVNTEYAYLQNFKILQNCFTRHGIDRPVNVEQLIKCKMQDNLEFLQWSKRYWDQYFPGGDYDAVARRRGSGAPPPATAPAPRTSAGTARRGTTPTTGPRVPKAGGVGGASSQALIQENNTLKETVTGLERERDFYFSKLRDIELLVQQACEEDPEIEKQEDGLIKHIQTILYSTEDGFEIPAEAEGVDDQETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM69</accession>
    <name>A0A194XM69_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_432179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10247" checksum="C8211F8776640858" modified="2016-10-05" version="1">MVISGSVGFLDAVKAYFTAMLTRKSNEKADIGRIYSATLMVEYVAMICVAPLWSAIYSLGYRLGGLGLGLPFFGGAVMMSLTLALVWKQGLESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMT9</accession>
    <name>A0A194XMT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_681706</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075447.1">
        <property type="nucleotide sequence ID" value="XM_018214354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMT9"/>
    <dbReference type="FunCoup" id="A0A194XMT9">
        <property type="interactions" value="1017"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XMT9"/>
    <dbReference type="GeneID" id="28824080"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681706"/>
    <dbReference type="InParanoid" id="A0A194XMT9"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="10"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="212"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="359"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="536"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ21092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="582" mass="64153" checksum="98F35D983E7415E4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMZ6</accession>
    <name>A0A194XMZ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_705178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075814.1">
        <property type="nucleotide sequence ID" value="XM_018217435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMZ6"/>
    <dbReference type="STRING" id="149040.A0A194XMZ6"/>
    <dbReference type="GeneID" id="28827161"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705178"/>
    <dbReference type="InParanoid" id="A0A194XMZ6"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="144"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="386" mass="42695" checksum="401D03A27C04D456" modified="2016-10-05" version="1">MKIIILGSGIAGLSAAIALRRSSHEVLVPIHLAPNGTRVLLTWGFSPLRAQLVTAHRSIYADGKTLQVNHEEVWDGVEGVYGARFYLAHQVDLWGELELLAREAGVRCFWGLGERGRGGERLIVEQDPENGVVMLADGTERKGDLIVAADGIHSRAVKYVVGFDNPARKTGTACFRCLIPSEEILGDEETRELMEGHEGLFRYLPDGEGRVLVWYPCRGNKVQNIAHIVPEHEGLGAREGEKAKDIKLWTLLSRDPLPTWHKSRLVLIGDAAHPMLPMQGQAGSQAIEDGAALGIMFSNFDATDEKSISDRLKMFANVRMNKASAMQKLSDMTLGDPEDLEKATQPYMPGETVPVTVAEQIRYRFSQNVFKDCEKELEKVKEQNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN50</accession>
    <name>A0A194XN50_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_637304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075874.1">
        <property type="nucleotide sequence ID" value="XM_018211524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN50"/>
    <dbReference type="GeneID" id="28821250"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637304"/>
    <dbReference type="InParanoid" id="A0A194XN50"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="517" mass="55079" checksum="95E5078A29095561" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN97</accession>
    <name>A0A194XN97_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_664796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075971.1">
        <property type="nucleotide sequence ID" value="XM_018212799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN97"/>
    <dbReference type="GeneID" id="28822525"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664796"/>
    <dbReference type="InParanoid" id="A0A194XN97"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="84"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="329" mass="36811" checksum="078B6CBF1D56DE33" modified="2016-10-05" version="1">MSTDKNSTESLASDVNFLSCLLTHPQISDLSSHPPVDCITLCVSSVLYQATTLFEILQSHPRLTKSLVLCGGIGHSTPLIYQAVSRHPKYRTITSEIQGLPEARVLERILNEFFDIEKITSQGCRILIEDQSTNCGANASKTRELLEKNGIETPKSMIVVQDPTMALRTVASFQKVYEGVEMDIRSAPIFVPVTRVGQEGQVEWDTSDVGITIEGLWEKERFYDLIMGEVPRLRDDTEGYGPKGKGFIVHVDIPGEVEDAWQRLVKTSNGQATLSPDLLSKRFVDMVATTSHYLPQSTTPLCPQHITHIIITWKYLFEYVVVKLPVYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XND8</accession>
    <name>A0A194XND8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_715505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075622.1">
        <property type="nucleotide sequence ID" value="XM_018218213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XND8"/>
    <dbReference type="STRING" id="149040.A0A194XND8"/>
    <dbReference type="GeneID" id="28827939"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715505"/>
    <dbReference type="InParanoid" id="A0A194XND8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ21267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="189" mass="20726" checksum="E27B5A9AEDB798FE" modified="2016-10-05" version="1">MASPSSYPPGTHHVPPPRASSPATANFRLNHLMLRITNPEASLRFYNDFLGLHTIFVFNTGAWTIYYLGPPSVSMSELGTASGLLELYHIPGHLDAYKNGNENGGEGFGHIGFTVPDVENALQRAAEFGFKVIKPLGENGVETMGVPSFVKDEDVVEGYKFVFRQLAFVVDPDGYWVELVPQVVRSPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT5</accession>
    <name>A0A194XNT5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_729321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076176.1">
        <property type="nucleotide sequence ID" value="XM_018219370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNT5"/>
    <dbReference type="GeneID" id="28829096"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729321"/>
    <dbReference type="InParanoid" id="A0A194XNT5"/>
    <dbReference type="OrthoDB" id="10480398at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="155" mass="17878" checksum="8E1A11C761A3C9AE" modified="2016-10-05" version="1">MATESPNLQAPDYSHTLSGFFHIYSHRKFLGFVADVEDCNRVLLTTHGRVSQREMEELYTSEVIRLYHEWCSDPRKGGGLPEERRVPFLSRAFKLMTSSEAYAYWDFKRAEDIRAKAQGTLIFDSVIRVAVREENARQESLEKTPINGSNKKSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNY4</accession>
    <name>A0A194XNY4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_665871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075797.1">
        <property type="nucleotide sequence ID" value="XM_018212877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNY4"/>
    <dbReference type="GeneID" id="28822603"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665871"/>
    <dbReference type="InParanoid" id="A0A194XNY4"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="227" mass="25094" checksum="EC86412DC3BB0A8A" modified="2016-10-05" version="1">MPKASRRSSGAASVSRAEPYPAIKPGDKPSTTSAAKSTKRTSSQKASTSSKASDSKVLTEKSPNKLNVPTLQTPPNNNSFLDVTLDTDAIYDTCSTVRQIINALLGKDNKNPKNLNPADVDKDGNPKPFTKASFCRAVGSRPDMLRRFMAAKKMMGGAESAIYPPAYKFFENKRVWEGAKKTKTREKVESDRPHGLPLREPQSYKNRRKIKPVRGSRLEDFLDEYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP83</accession>
    <name>A0A194XP83_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_768128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076244.1">
        <property type="nucleotide sequence ID" value="XM_018221773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP83"/>
    <dbReference type="FunCoup" id="A0A194XP83">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP83"/>
    <dbReference type="GeneID" id="28831499"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_768128"/>
    <dbReference type="InParanoid" id="A0A194XP83"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000298">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="49661" checksum="66E458347356F9F1" modified="2016-10-05" version="1">MTDKLPPNLLALFAPRPPLRFLPPSDHPSGERKTREITGLAQFMPSLKEYVETDEYEPTESWLQKHDRKKLEKKERQENLLKEGPMSCEGTPICPEYLLSSLSEIWTHVSHLEQDMLTVFSIDKPQDDPNIRGDAFKTLIVARLSYDATEQDLESEFGRFGSIERIRIVVDTHQAEKKNKKAKKHRGYAFVVYEREKDMRAALENCDGIRIKDRRVKVDVERGRTVKGWKPRRFGGGLGGRGYTKAIPPRPVGPGGFGSAPGGPGGFRGGFRGGFDGGRGRGGFRGGFQDRGGYGGGRGGIGYQGGGGFSRGGGDRGGYGGSNGYGAPPNAPAGPGGRGGGGFGGGRGGYSGSGSPDRNGPGYSAPSGGYDSRGGGRSYEDRNGGYRGGNRSYGDRDAPRGGSGSNMEPVRPRDGGFRDRDRGDRDGGYGGRPREDDSRKRGYEGNSYEEDPRKLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQR2</accession>
    <name>A0A194XQR2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_728737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076970.1">
        <property type="nucleotide sequence ID" value="XM_018219296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQR2"/>
    <dbReference type="FunCoup" id="A0A194XQR2">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQR2"/>
    <dbReference type="GeneID" id="28829022"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728737"/>
    <dbReference type="InParanoid" id="A0A194XQR2"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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        </source>
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</entry>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
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            <end position="505"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ23253.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
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    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
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        <property type="entry name" value="Fn3_2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ23546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42242" checksum="621C350B12E7F40B" modified="2016-10-05" version="1">MLISLTVGKVDAGVAVLLTQDKRLIEFPSILLPPNISSGSIVDITVARNVASEQKSQAAFHALQDAIYSSFGESEPAAPVLRCRNATQTSVVLEWDPIETATAECISLSLFRNGQKAGNIPRPTQMQSTKISGLAVDTEYTFHLVLRTSAGTYSSEKVVVKTHKMTDLSGITVTPGILPSQLKESLTKAIERIGAKIAPSVRIDTTHFVTTEGRGIDWEKAVEMNIPVVRPEWVEGCERGGRIVGVRQYYLDADPRQRQIAQAEIPQQAPPTEQPKSPPTSPPANGQTNGSSQAIPPTPPAKDVPNQEEEDSEEEGDEEEEKEKTAIPDEQKVRVEDRDQHKVALRPAAPASEDSDEPDEPEEKGRETAEEGNGSGSQTPGHSSFQDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV52</accession>
    <name>A0A194XV52_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_680313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077942.1">
        <property type="nucleotide sequence ID" value="XM_018214050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV52"/>
    <dbReference type="FunCoup" id="A0A194XV52">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XV52"/>
    <dbReference type="GeneID" id="28823776"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680313"/>
    <dbReference type="InParanoid" id="A0A194XV52"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ23587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="13222" checksum="BA3A8D295D364FEE" modified="2016-10-05" version="1">MLLFCPSCSNVLTVSQISVEGDETPVNRLECQTCPYQYIITKRYFERRAFVRKEREDVFGGPGAWDNADKIKIQCPKDGCDGDEAAFFQVQIRSADEPMTGFYKCMTCGNRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVT1</accession>
    <name>A0A194XVT1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_4094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078182.1">
        <property type="nucleotide sequence ID" value="XM_018207312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVT1"/>
    <dbReference type="GeneID" id="28817038"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_4094"/>
    <dbReference type="InParanoid" id="A0A194XVT1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="28018" checksum="5479D70A8C29B10B" modified="2016-10-05" version="1">MTLLQKLIMLLPENFTRTFHNYRKLHNLDIESTYPAFEKTTLQHQEDMAAQMNNLQQFPNITYHTTPTRDFDRSECRAWIFEFLHHGLELSQIDAARKAMRWMYTGDRLFTYSEQQMIDVFGLIVGGGLWSRMQTERLTERFLEYAETVEKIKRNTTTIRDNVNPKTQTQMILAELFVIALFMTSVMISVGLARYQAKHPGEWNDQWWLLVFLVFGAFLLAYFLSAGPESSPLAIIVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWB2</accession>
    <name>A0A194XWB2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">LY89DRAFT_679571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078781.1">
        <property type="nucleotide sequence ID" value="XM_018213897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWB2"/>
    <dbReference type="STRING" id="149040.A0A194XWB2"/>
    <dbReference type="GeneID" id="28823623"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679571"/>
    <dbReference type="InParanoid" id="A0A194XWB2"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWJ1</accession>
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        <name type="scientific">Mollisia scopiformis</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="KUJ24598.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        </location>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="676" mass="73988" checksum="770872D6099C7A03" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1Z2</accession>
    <name>A0A132B1Z2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_743877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="KQ947447">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220995.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A132B1Z2">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B1Z2"/>
    <dbReference type="GeneID" id="28830721"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_743877"/>
    <dbReference type="InParanoid" id="A0A132B1Z2"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ06400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="27015" checksum="CFA43A5EF799004C" modified="2016-05-11" version="1">MALHPPQNTSKLIFAPANDKTHSQADQYTKGALEISQLDPRDPFTQFHAWFTLAQQSGVHQPETVCLSTASLPSGRVSARMVYLKELDSKGFVIYSNFGTSKKARDIAGNKWASLTFWWREMERQVRVEGMVERLSSEESQVYFDTRIRGSRVGAWASRQSEVLGEGRGQLEGWVREVEGRFEGEERIPVPGFWGGLRVMPEMVEFWQGRESRLHDRFQYVRMEGGEWKIERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B487</accession>
    <name>A0A132B487_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">LY89DRAFT_661417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061184.1">
        <property type="nucleotide sequence ID" value="XM_018212604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B487"/>
    <dbReference type="FunCoup" id="A0A132B487">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="28822330"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661417"/>
    <dbReference type="InParanoid" id="A0A132B487"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="232"/>
        </location>
    </feature>
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        <location>
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            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="560" mass="60174" checksum="8E175A376F2FF362" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5V2</accession>
    <name>A0A132B5V2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_742861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061988.1">
        <property type="nucleotide sequence ID" value="XM_018220885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5V2"/>
    <dbReference type="GeneID" id="28830611"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742861"/>
    <dbReference type="InParanoid" id="A0A132B5V2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="22215" checksum="F4BE4E764D9C18F5" modified="2016-05-11" version="1">MADANAPPAKKATKGKAAAAAKKTRPAASKVFKYSDPSTLANQEPVDVTFLMWPKSEEEEEEEEEEDDDSDDDKAEVGPLQAILDGFENEREKAYSEAFDSFVKEKGIFSGGELIDLRKKVSAPFEKRADVAREEAVRSGRMKKDEAKAIKGISDKDRKEKRKNKRMLQDRLNEIQRERNTAVHEALNKGGPKAMTVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6F0</accession>
    <name>A0A132B6F0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_677608</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062188.1">
        <property type="nucleotide sequence ID" value="XM_018213690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6F0"/>
    <dbReference type="GeneID" id="28823416"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677608"/>
    <dbReference type="InParanoid" id="A0A132B6F0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="309" mass="35779" checksum="029C85B5B0FCDD44" modified="2016-05-11" version="1">MLRLRRPLMKSHSYLEDSKLRLDHMTYRDSDFVKKSVSKPSHFMISFSREMGEIQSLTHFHFCRQASQLVCRPQNRNSVNLDQIKLTVSNRSVMACSTVGTPDYVDALRVIRQMQDGSFKLKKSVSKPAKKSVSKPAKAKYFGTPDYIAPEVCGPMRYSRVIARSWWRDEPPTPVWRTHAGLPPPRPGQSPMKERCWSTSPGYRGRSRIRQRTQQISRTHFQSSKESAMIRSRRSFHKPGPYARPSDWYCTHLGARWLGTWRGAQMSSFCNCTRWGALYRYGVGFSEATPVILKALKRLIEMELRLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6J2</accession>
    <name>A0A132B6J2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062228.1">
        <property type="nucleotide sequence ID" value="XM_018220849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6J2"/>
    <dbReference type="GeneID" id="28830575"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742634"/>
    <dbReference type="InParanoid" id="A0A132B6J2"/>
    <dbReference type="OrthoDB" id="3529261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34821" checksum="642BD78F8F2F59B0" modified="2016-05-11" version="1">MPYTNLGQLHAHEQSSSDLISRVTAAATFSNGITSVQMSGIERFGKVINEVSGKVASEQLVEKFFHLFDDIFFNRSLRYGVTPKLERKSLPINTCCRGLAPGGKLIVQIGDSLTTSKVTLLGRLLHDMIHAYLWRYAHRSFTDDKLFENGWGFSGHGKAWQDMALVVEDFTKQYLLPLDLGRNEALLMELEQFAEGLNALKASPAGVNKLENEIAKEQLESEVLGASGKAVSKSKMPTTEERSRNMRRSSPMRRRTNRLTKQIPAHIEKARAQKLSQQTLPLSGHDLEVREILKQTADDCIGVLKALKVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B750</accession>
    <name>A0A132B750_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin-binding monooxygenase-like protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_630049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062587.1">
        <property type="nucleotide sequence ID" value="XM_018211228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B750"/>
    <dbReference type="GeneID" id="28820954"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_630049"/>
    <dbReference type="InParanoid" id="A0A132B750"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="564" mass="63885" checksum="D8EF7C89FD4714BD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7H7</accession>
    <name>A0A132B7H7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_764996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062558.1">
        <property type="nucleotide sequence ID" value="XM_018221653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7H7"/>
    <dbReference type="GeneID" id="28831379"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_764996"/>
    <dbReference type="InParanoid" id="A0A132B7H7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013221156" evidence="1">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="133" mass="14025" checksum="681FC5B8257F4789" modified="2016-05-11" version="1">MRLTFLIFGLGAIAAIEPHMKRLPIALTSPSAEDQWEWSKMELIPRGCPGGDGATCCPEGTFSCSDGERCICQACGICCGDPCGSGNCWRPLGYQGHDLGSGCINTVPVQPAVLLLALLHGYDFLISVSGFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7K3</accession>
    <name>A0A132B7K3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_631275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062012.1">
        <property type="nucleotide sequence ID" value="XM_018211273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7K3"/>
    <dbReference type="GeneID" id="28820999"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_631275"/>
    <dbReference type="InParanoid" id="A0A132B7K3"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF162">
        <property type="entry name" value="SATRATOXIN BIOSYNTHESIS SC1 CLUSTER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="391" mass="43938" checksum="F858D24A530249CC" modified="2016-05-11" version="1">MGFTDVEDLNSRQFTLLTWFMWGTGLLLTTLRFAVRYHYFRDFFWDDFFQVIGMLSLTALAVVTQLQRDKIYALKAAAPPDGDPAERTYKHVITDATRDQAKLQFASIFLFWICLWAIKGSLLMFYRRLFYNLPKYMKWWWAAAVACIATFIACVLTNFLECLPMSHRFELDLQGSCPTDNGIRFVATTTTLDILTDIFLMALPIKLLIGLRISMKQKIGVGVMFTLSILIVIFSAIRVSEIYTSLSQLDPNLNVSLALWSILEAAVAVVVGALPSLKSLMRGKRDSSYGSHTRTPKGPYLRSTNAGTKGSRASKALDPTTSASENGRGKQRDVEDLQGDEIPLEALPPTTPDNLKRSGIMRTRDIVISSYTPKSMDSRDEVTIESFIRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7M8</accession>
    <name>A0A132B7M8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoin dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_690889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062757.1">
        <property type="nucleotide sequence ID" value="XM_018216190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7M8"/>
    <dbReference type="GeneID" id="28825916"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690889"/>
    <dbReference type="InParanoid" id="A0A132B7M8"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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    </dbReference>
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        <property type="term" value="F:quinone binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
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        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
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        <property type="entry name" value="GDHRDH"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="29014" checksum="99E0DE2A0878B370" modified="2016-05-11" version="1">MASNGNGTTVAKHQGKRTVIVTGSARGIGKAIALRLAEDGFDVCINDISANKSGIESTVKEIQALGRQSYGHVADVSKLSEVEALIEASVKNLGPLNVMIANAGIAQVKALLDLTEDDVRRMFEVNVFGVFNCYSAAAKQMIKQGSGGKIIGAASIVAYKPFVMLSHYSASKWAVRGFTQAFAMEMAEHKITVNGYAPGIVGTAMWDLIDEELGKKTSVKKGDTIKKYTDDLIALGRTSVPEDVGKTVSFLASPDSDYMTGQTLIIDGGIIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7P2</accession>
    <name>A0A132B7P2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_741785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062770.1">
        <property type="nucleotide sequence ID" value="XM_018220757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7P2"/>
    <dbReference type="GeneID" id="28830483"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_741785"/>
    <dbReference type="InParanoid" id="A0A132B7P2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36982" checksum="EA7A4F12724EAB2F" modified="2016-05-11" version="1">MYASSSFTGVVLEAPPNFPPPKPGSFEDIHGLGQAYDRALHFCKSDGLENWDMSRFGFYDDPELDRIEVYRRTFENFVTYFPEFLLLPFQDVGLNAEFMICALWLVHHDPTGKQFKYYRLPYWLYSLQVTIFPDAPCPFSVLPDIESERVLDLADNHEDHQENQDLIGGESDDDNMGGSSEAESSIRRESRSNLNNNIDANSTGAKGPNTAATNNSNTDLPNSANNGKSVSNTGPVLVDQAELPRCEPCRAAKRICDHKWPCSSCVVKFGANARVKCEAEIPIGLPDSLGTKKGYYGHKTGIMVEREISTGRFYRIPKGASFIMPGGCYHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7W3</accession>
    <name>A0A132B7W3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_711558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062851.1">
        <property type="nucleotide sequence ID" value="XM_018217911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7W3"/>
    <dbReference type="FunCoup" id="A0A132B7W3">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="GeneID" id="28827637"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711558"/>
    <dbReference type="InParanoid" id="A0A132B7W3"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF200">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="598" mass="65892" checksum="3E4E49B67E28B6AD" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8U1</accession>
    <name>A0A132B8U1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-crosslinking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_788716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063171.1">
        <property type="nucleotide sequence ID" value="XM_018223189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8U1"/>
    <dbReference type="STRING" id="149040.A0A132B8U1"/>
    <dbReference type="GeneID" id="28832915"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788716"/>
    <dbReference type="InParanoid" id="A0A132B8U1"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000087">
        <property type="entry name" value="Putative frg1-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ08816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="30514" checksum="F4F434962B291A31" modified="2016-05-11" version="1">MVKPLTFKGDKKAKKRKRVDTEEKFGNGETSTSRELTTTQKDEDPAVEDDSWVTAEATGDVVGPIVLVVPSEPPSCIACDAGGKVFASQLENIIDDDSSTAEPHDVRQVWIANRVAGTETFSFKGHHGKYLSCDKFGMLSANTEAVSPLESFLAIPTADTPGTFQIQNLRETFLTIKPSTSAKSNALPEIRGDGEAITFNTTFRIRMQARFKPKLKASKEEKAREKISRKELEEAVGRRLEDDEVRKLKKARREGDYHEALLLIKVKNKHDKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B956</accession>
    <name>A0A132B956_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PIG-P protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_562313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063293.1">
        <property type="nucleotide sequence ID" value="XM_018208473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B956"/>
    <dbReference type="FunCoup" id="A0A132B956">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B956"/>
    <dbReference type="GeneID" id="28818199"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_562313"/>
    <dbReference type="InParanoid" id="A0A132B956"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="11044" checksum="B4DA7DE22E673F1E" modified="2016-05-11" version="1" fragment="single">KVPTYEYYGFVLYLFSSLTFLMYLLWSYLPSPFLHALGIYYYPNRWWSLALPSFLVMLLVYIYVALASYNTGYLTLPLSSIETIIDDAANVVTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B988</accession>
    <name>A0A132B988_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_316605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063323.1">
        <property type="nucleotide sequence ID" value="XM_018206676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B988"/>
    <dbReference type="FunCoup" id="A0A132B988">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B988"/>
    <dbReference type="GeneID" id="28816402"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_316605"/>
    <dbReference type="InParanoid" id="A0A132B988"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288008" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ08968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="378" mass="37978" checksum="7464BC3AF1E17984" modified="2016-05-11" version="1">MVHFLQTLGLVLTTASVLTVASPLPQPASELNDAPTKVKRATCTFTAAAAAIASKKSCSQITLSNIAVPAGTTLDLTGLASGTEVIFSGTTTFGYEEWSGPLISVSGSGITVNGASGSKIDGGGARWWDGEGSNGGKTKPKFFYAHSLTGSSIIENLSVLNTPVQAFSIDGANGLTLSHITIDNSAGDTGGGHNTDAFDVGDSTDVTIANAIVQNQDDCLAVNSGTSITFTGGTCSGGHGLSIGSVGGRSDNTVSDVTISSSTIKNSMNGVRIKTVSGATGSVKGVTYEDITLSGITQYGIVIEQDYENGSPTGTPTTGVPITVLTLDGVTGTVSSSGTNIYILCGSGSCSDWKWSGVSVTGGKKSSSCKNVPSPASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9J6</accession>
    <name>A0A132B9J6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_599518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062899.1">
        <property type="nucleotide sequence ID" value="XM_018210096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9J6"/>
    <dbReference type="STRING" id="149040.A0A132B9J6"/>
    <dbReference type="GeneID" id="28819822"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599518"/>
    <dbReference type="InParanoid" id="A0A132B9J6"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
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    <sequence length="1047" mass="116286" checksum="51E6EB81D38B9F1A" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9W7</accession>
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        <submittedName>
            <fullName evidence="9">Putative polyketide synthase</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">LY89DRAFT_628214</name>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">CBS 120377</strain>
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        <source>
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        </source>
    </evidence>
    <sequence length="2167" mass="236035" checksum="7986C8ECFC5F27B4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Z5</accession>
    <name>A0A132B9Z5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_281133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063580.1">
        <property type="nucleotide sequence ID" value="XM_018206450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Z5"/>
    <dbReference type="GeneID" id="28816176"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_281133"/>
    <dbReference type="InParanoid" id="A0A132B9Z5"/>
    <dbReference type="OrthoDB" id="4203030at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="213" mass="24337" checksum="1797B20C0C4F6266" modified="2016-05-11" version="1">MEHPPPYVPHEPITTEDLETASIRSAAPSYVSDTPTYVSTIPPSPPRTGLPPIPPLPAPPANPNPSLDAYRISSWSKTQTSNPTTKHYQRIAQRRASNLTRQQQSCLLIAALNGEDGIAQIKKKMDAEQRAKNIRTNEDPYLVGEEAAEQNRQERLRKENGWGVLEREDKRWDWLLAQMSDWEERDKNWKRFRKEVITGNRRKLSNRFGFGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBB7</accession>
    <name>A0A132BBB7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_275618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064041.1">
        <property type="nucleotide sequence ID" value="XM_018206409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBB7"/>
    <dbReference type="GeneID" id="28816135"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_275618"/>
    <dbReference type="InParanoid" id="A0A132BBB7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="13886" checksum="9577A702F8644BC2" modified="2016-05-11" version="1">MKYLGSAPSCSIGLGKSIHKRRLLQDDKTSLECTDAHRHQILLLGGITLALVLPVPANAAEAVISCEEAFETPNDHGLELHPSTRNETNAVGLNKRKQSCRPCEPGPRISAAFAGKWRSWTVSREQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBR1</accession>
    <name>A0A132BBR1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_287976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063794.1">
        <property type="nucleotide sequence ID" value="XM_018206493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBR1"/>
    <dbReference type="GeneID" id="28816219"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_287976"/>
    <dbReference type="InParanoid" id="A0A132BBR1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="500" mass="55076" checksum="F2BE26AACEEC6EDB" modified="2016-05-11" version="1">MQYGVDSAAVGALQAMPGFLKVFGYEDPTSALGYGIDSTVQQLITSLLTLGSFVSSLIAGFFSAYVGLKQALWLACAFNAVAVAIQMATTSKGVLYFGRLLLGLANGFFVTFSNVYTAEASPAHLRGVMVALFAYWVNIGSILGAVVDNFTRVRLDKASYQIPLGCLYIVPTVLTIVLFFVPESPRWLLHKGRDQQARKALETLRGNSVESKYIELEWAEMVRGVEEEKNLAKSIDFLDMFRGTDLRRTLLCYGMIACQTASGVWFLIGYQTYFFGIAGITKSFQFSIMNTCIGFVGVNVGMYAIRHIFGRRSILILGATVCGLSQLASAIAYTIKPTTTTTGQVLVAFTAIFYFFYNGCVGAASYPVATELVSSRLRAWTVGTATSLGYILAWLVGFCSPYFINPQDLNWGPKYGYIWAGSNALCIVFFFFFMPEMKGRSLEEWDEIFNARTPAWKFKSFQCTIKDEAAFDMQEKSGVRIEKEGGILSNEVEDVSGNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC14</accession>
    <name>A0A132BC14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_628514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063749.1">
        <property type="nucleotide sequence ID" value="XM_018211183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC14"/>
    <dbReference type="GeneID" id="28820909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_628514"/>
    <dbReference type="InParanoid" id="A0A132BC14"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="124"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="698" mass="79668" checksum="D327683DA328063C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCN6</accession>
    <name>A0A132BCN6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064114.1">
        <property type="nucleotide sequence ID" value="XM_018220643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCN6"/>
    <dbReference type="GeneID" id="28830369"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740831"/>
    <dbReference type="InParanoid" id="A0A132BCN6"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="487" mass="54813" checksum="7E41AEDE47FD4E9C" modified="2016-05-11" version="1">MVNFGRSGACITCKQRKVKCDESRPGCQKCHKIGKSCPGYPDKWDLAFRNENKIIQRKVQWKQKALEEFPSAKLLMLENALADERLQALCLFFQDYTISTCGICPGWLHFLPKMYQMSAATSLLHHAVCTAAYANLAQKTERPDLAIMAMSHYRESLEVVKQTLVFPGTAFDDSTMTGVILLGIYECINSTLVEGSYHHISGLETLADLRGSLLMQGYGPSLLQTVCCQMLRRILDRRVPPSSVDERLVKLLDPSLLGNEMIINKLEISKFIANVDAKILSGQIQRHWDEILLEFERLEGGLFHWNMRASQEFGFVQVQQPTFIDDKKPFVYHSYLGFWSLSLWNKHRAARILLHQTLLDGLDAMDSGRLSSINQDQKSISKSVIKEMADFILLSIPFSLGDVPLPPSLNGPKSVGGYFLVWSLQVLLRCPSVSDDQQNQAKNALLRIGRRCGLSYATIFAKKYGNSSPTQIVKHVPPQQIPLGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCP6</accession>
    <name>A0A132BCP6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_657263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064124.1">
        <property type="nucleotide sequence ID" value="XM_018212421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCP6"/>
    <dbReference type="ESTHER" id="9helo-a0a132bcp6">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28822147"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657263"/>
    <dbReference type="InParanoid" id="A0A132BCP6"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000499">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007230023" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="51"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ09769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="577" mass="61495" checksum="2E6D41AE13CF45EC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDK4</accession>
    <name>A0A132BDK4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_656317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064865.1">
        <property type="nucleotide sequence ID" value="XM_018212377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDK4"/>
    <dbReference type="STRING" id="149040.A0A132BDK4"/>
    <dbReference type="GeneID" id="28822103"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656317"/>
    <dbReference type="InParanoid" id="A0A132BDK4"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29634" checksum="3E97548676A78C0D" modified="2016-05-11" version="1">MEFRRAADVLLRSQTSPLATALNPRTAVRWTNKAQLDYSSCPNRPASRCLATSSRRYALKNVPTTTSAPLPQTTTSTTNSSSTNAPAPKSPFGGLNDSLGWISGNKSRSSFPIPRAGGSFEKTLNGGSSASDLLSGIINRKQQRAGGVQVDRMLDPGSMLDPDNLAKQMTFDTAEETMVHRSKRVPIKLGPSTGRSVTMGAGLDVGRGFRLLEQSCARNKVRADANKQRFHERGGLKRKRLRRERWRRKFMEGFKATVVRVKQLKNQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRT0</accession>
    <name>A0A194WRT0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_595657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065050.1">
        <property type="nucleotide sequence ID" value="XM_018209874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRT0"/>
    <dbReference type="STRING" id="149040.A0A194WRT0"/>
    <dbReference type="GeneID" id="28819600"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_595657"/>
    <dbReference type="InParanoid" id="A0A194WRT0"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="321" mass="34862" checksum="BAFB7FE4050FD93E" modified="2016-10-05" version="1">MKGLRRVIIQCSIPRVVTRRAYSSEAPLIKVLDVQAPNSGRMRILSLARPAARNAISRALLHELRTNIDKIASEYDTENNEVPPQKIFGGAAEVDERGPTRALVLASEVDSCFCAGADLKERAGFSPEETAAFLANLRNTFSSLAALPIPTISAISSLALGGGLELALCTHMRVFASTATVGLPETRLGILPGAGGTYRLPALIGLGRARDLVLTGRRVSAAEAYFLGIADRLVEVLPKEGEEGKEELMTRAREEVLREAIRLAGEICEGGPIAIRSALQAVNYAREEVENKMYERVVATEDRNEALVAFREKRRPVFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT98</accession>
    <name>A0A194WT98_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_239181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065535.1">
        <property type="nucleotide sequence ID" value="XM_018206088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT98"/>
    <dbReference type="GeneID" id="28815814"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_239181"/>
    <dbReference type="InParanoid" id="A0A194WT98"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28168" checksum="74E417DB582D7112" modified="2016-10-05" version="1">MPSLTLDTTTSPHTQEHGQTQSTSRSASPVRAPPYSPITPTLSTARPIFTHTSQPPPAPIPQPPPETIDFSTNPDVLALKATMSILQQQKKTAEQDMKLLADTKERALRDPERFATALTEGRIHTRGDTLFNPSNEADSDEEMEDADDLGQIESGRQAVARATNEEKWKPLPTPQNVVRMPAVNWEQYGVVGDSLEKIHKDQIARPNEGIPQKMGPDGKFQAGSEGQRRDYLGIAAPYNPLKDKIEKSGTKKSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU82</accession>
    <name>A0A194WU82_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_238894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065522.1">
        <property type="nucleotide sequence ID" value="XM_018206080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU82"/>
    <dbReference type="STRING" id="149040.A0A194WU82"/>
    <dbReference type="GeneID" id="28815806"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_238894"/>
    <dbReference type="InParanoid" id="A0A194WU82"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="640" mass="73111" checksum="344FB96A4F7A07D9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVB4</accession>
    <name>A0A194WVB4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_653422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066263.1">
        <property type="nucleotide sequence ID" value="XM_018212252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVB4"/>
    <dbReference type="FunCoup" id="A0A194WVB4">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="GeneID" id="28821978"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653422"/>
    <dbReference type="InParanoid" id="A0A194WVB4"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40471" checksum="77613E34508C0D29" modified="2016-10-05" version="1">MASASSLPIKLIAFTTALVLGASASRINLRTLIINTFTGPGMYSRIAAALLVLANLKNVPWAWHYRVFQGILYHCLFNKPNIPLDIAPSTLFLPVITSSYSPLLECDYNFHKSNSTYFSDLDVTRSHLICALIQPGIEKLQHNAREKLVLDKEGKPVLGKWSIMLGGVMTTFKREIGMYQGYEMWSRLLAWDRKWVYIVTHFVKKGAVKPKEYILTDGSWFGKGKKYQKVNQNGHASEATGEDLDEKAIFASAISKYVIKLGRLTIHPEVSLEAAGMLPPKPGGWATMTNSGESTPETLEVVETDDAAQESSTGDEWNWKRIEEKNNQGLKLVEHFAALDGLHGEFSGSKEPALGRYRDFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVU7</accession>
    <name>A0A194WVU7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066441.1">
        <property type="nucleotide sequence ID" value="XM_018220396.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RGS"/>
    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="199"/>
        </location>
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        <location>
            <begin position="228"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="726" mass="79038" checksum="6A0773955251E258" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVZ4</accession>
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        <submittedName>
            <fullName evidence="4">RCC1/BLIP-II protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">LY89DRAFT_233187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="28815769"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_233187"/>
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    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
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            <end position="174"/>
        </location>
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        <location>
            <begin position="175"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="362" mass="38331" checksum="BB1C08DBA95AABE6" modified="2016-10-05" version="1">MTTIYAIGSNGSGQLGIGHKEDVSVPKQVLFANDPDQPITQVKAGGNHTLLLSSGTLYCSGDKTTGACGIVSGTSENDIRFYQLRLTSEDSTLNTTPTVFCAATWEVTVVVQKDEHGRNTQLYTLGIGNKGELGQGEFLFRSAKASLINNFPPDNLEVVDLAAAVSHVVVVLSNGDVYGWGSGRKGQLGQPEGIVHSPRKISQLDFKVVKAVCGREFTYLLGEPTSGRYTILGSDKAGVKSSAPEDVRQWKDVGASWGSVFVLKQDGTLLSWGRDDHGQLAPAGLPPLSHIAIGSEHGLGLTKDGEVLVWGWGEHGNCGPDTTDGDVQGRWNVIASSKYLPAESKISSIGAGCATSWICLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW48</accession>
    <name>A0A194WW48_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyphenylpyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW48"/>
    <dbReference type="FunCoup" id="A0A194WW48">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WW48"/>
    <dbReference type="GeneID" id="28826829"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700109"/>
    <dbReference type="InParanoid" id="A0A194WW48"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="61"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36629" checksum="6A7869E4E6385D1A" modified="2016-10-05" version="1">MSRPAILQIGDIVHSQKEWSELGSFADLKVFKGSKSRAGFLKEIESGSYNDVVALYRSNESTTITGPFDAELISKLPSSLKYICHNGAGYDNIDVAACTSRNISVSSTPIAVNNATADIAIFLMLGALRRIHIPYSAIRSSKWRGNSQLGYDPQNKLLGILGMGGIGREVAARARAFGMKIQYYNRSRLSPELEQGAKYVSFEELIKTSDVLSLNCSLRKETVGIIGKKEFGMMKDGVIIVNTARGKLMDEEALVQALESGKVFSAGLDVYEKEPKVHQGLLDNPNVVLLPHIGTATKETQRNMELLVLENIESAVKKGILITQVSEQSSSGSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWQ0</accession>
    <name>A0A194WWQ0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_738188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066753.1">
        <property type="nucleotide sequence ID" value="XM_018220343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWQ0"/>
    <dbReference type="STRING" id="149040.A0A194WWQ0"/>
    <dbReference type="GeneID" id="28830069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738188"/>
    <dbReference type="InParanoid" id="A0A194WWQ0"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16516" checksum="EA311551FECCF7D0" modified="2016-10-05" version="1">MSIDLVGGSLPAGELPINCLIRESHEESGLSSEVVSKLAKPVGTISYVTSSDTKTTSGGESGLIRAEVQFIYDMKVGPEIVPMPYDMEASSIDLFTIDEIKNALDDGEFTPANACLMLDFFIRHGLTTFENEENYTQIISRLHRSSGMQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX71</accession>
    <name>A0A194WX71_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_722161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066941.1">
        <property type="nucleotide sequence ID" value="XM_018218710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WX71"/>
    <dbReference type="GeneID" id="28828436"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722161"/>
    <dbReference type="InParanoid" id="A0A194WX71"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="302" mass="34726" checksum="2C67BF035F5C8518" modified="2016-10-05" version="1">MFGFKFGKQSLPYMEKDKTVYAPLQDGRSSSSDEGDRDEKPMSYTAPAGRSPRFWKLSVIALLLVTNITTFVGLFAVKHLTKRVNSHAALDLDYAPNSWARIDELPTQYNRLNWWTEYSDKNFTEGDMLWDNMNTAHGFIAMDRTWAKERHWPDSMHFPSDNSKNVYLLEAYHLLHCVGVIRKTFWEAVNRADHYTFNPPHSGHCLDMLRQYIVCKADTTPLYVFGDDTAGDEQYRKCNSWDALRQFATDNTACYRDTPKGVDQSTFPFGDHFGYCDGGYDGVKQGERRGPWKHGAVWDGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYE6</accession>
    <name>A0A194WYE6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_699518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067315.1">
        <property type="nucleotide sequence ID" value="XM_018217061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYE6"/>
    <dbReference type="GeneID" id="28826787"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699518"/>
    <dbReference type="InParanoid" id="A0A194WYE6"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267603" evidence="8">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="276" mass="31432" checksum="32A1B182C811A204" modified="2016-10-05" version="1">MIPFLAFFPWIMRILEALPQSLTSRLSLDYEQFLAEKNVCPSPDLFPPTTTASFEDRQHRTIFHDILDSKLLPEEKFLDRLADEAAVTLSAGTLTTAWVLAVAIYYMLANPLLLKKQKLELEAAIPDPSQHTPLATLDTRPYLRAVIQESIRLGYGAPGRVCHIAPDETMLVSSSRDLAILPATPTCMTVYLMHHVESIFPSSYTFNPERWIENPRLDKHLFAIFRSWGSKECRFESDKGVLKLWETETWDVELVGAMVLTKVWNGTKGVRIRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYR6</accession>
    <name>A0A194WYR6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_737741</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067189.1">
        <property type="nucleotide sequence ID" value="XM_018220293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYR6"/>
    <dbReference type="STRING" id="149040.A0A194WYR6"/>
    <dbReference type="GeneID" id="28830019"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737741"/>
    <dbReference type="InParanoid" id="A0A194WYR6"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:electron transport chain"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NDUFB3"/>
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    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10020" checksum="22D0562F2D8CC73E" modified="2016-10-05" version="1">MRSTGVRRAPRPNITGFDPKAFAAASGSPANDPWARAEAWRYSGPFTRFNRFKGSFPGLGIATVAFAAYCGYEYMFLSDDHGHGEGHGEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ94</accession>
    <name>A0A194WZ94_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">DUF726-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_622072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the TMCO4 family.</text>
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        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
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        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="673" mass="73747" checksum="89C3AE0A4D7853F4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZX1</accession>
    <name>A0A194WZX1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_737474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
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    </dbReference>
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    <dbReference type="GeneID" id="28829986"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737474"/>
    <dbReference type="InParanoid" id="A0A194WZX1"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="188" mass="19985" checksum="C446F3E1E63019F6" modified="2016-10-05" version="1">MAQAMASTNGNWFCQPVSGIQYSNVGSLGTYNRIMGAAQLTPASQFAVEQKVRQKALELQGARTPRMTTTEATRGPAYAANGKGQRILEVTRTGGVQRISCAKNFNGSTGRPRVSHLPAAAGNLPLQADAEILTSEGKELSVEFDKTVANFTPSYHGFGGNVATLIQAIEARKAGNEANVKNVTRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZZ8</accession>
    <name>A0A194WZZ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_651398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067634.1">
        <property type="nucleotide sequence ID" value="XM_018212157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZZ8"/>
    <dbReference type="STRING" id="149040.A0A194WZZ8"/>
    <dbReference type="GeneID" id="28821883"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651398"/>
    <dbReference type="InParanoid" id="A0A194WZZ8"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056027">
        <property type="entry name" value="DUF7608"/>
    </dbReference>
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        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24581">
        <property type="entry name" value="DUF7608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="677"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="954" mass="105220" checksum="31799EB92F9CB6C7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X073</accession>
    <name>A0A194X073_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_160375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067946.1">
        <property type="nucleotide sequence ID" value="XM_018205497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X073"/>
    <dbReference type="GeneID" id="28815223"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_160375"/>
    <dbReference type="InParanoid" id="A0A194X073"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="382" mass="43823" checksum="6672E1D1C7FCD815" modified="2016-10-05" version="1">MTSTFHTTAQSNCLTSVSILQLITGTTMRLLQKLFFWFRKSSDIDASYLLQGLPLDILLCIVAFLPAESAVALSLTCKQLKHLLWDDHSPTLGSSPKAKVALLELLALDLPNFIACSPCGRLHDIENVLWYNSSTYNYNPRSRNRENRLPACIQRDQDSDLDDITYTFGTTAFKMAVKRYHQKPDCKKVLKLMSSRSVYFSKWDEWVVAWREECRVVGGSLMHCWQSVHISSNYSYLASHSVTPRNVRICTHVAFNGSTKKSGICCRCRTEWRIDSKYYNLRGRAVFLTWKDLGTGPESEVFRQHNTYTPESSFLRYFFTNRQEAQAQTQTHSNQLPAAVGVVGDLSSAFGDGNLEFDSWLDSRSRKQLFQYQDIYRAMSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0X4</accession>
    <name>A0A194X0X4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_591007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068195.1">
        <property type="nucleotide sequence ID" value="XM_018209633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0X4"/>
    <dbReference type="GeneID" id="28819359"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591007"/>
    <dbReference type="InParanoid" id="A0A194X0X4"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="138" mass="15253" checksum="89B5B5A55E5F4B9E" modified="2016-10-05" version="1">MAMTFFTATDTPLYSMSWMPMTTGQYAGTCIFLIAFATIFRALLAVRVNFFEFLKVLKYRREGGGGVKFGYEEKVAVRPWRVNEAVMLGSMDVVLAGIGYLLMIAVMTMNVGYFMSVLAGVFLGSFIFGRFMASAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1H7</accession>
    <name>A0A194X1H7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_721179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068401.1">
        <property type="nucleotide sequence ID" value="XM_018218619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1H7"/>
    <dbReference type="GeneID" id="28828345"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721179"/>
    <dbReference type="InParanoid" id="A0A194X1H7"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13439" checksum="95664C67FFBAB557" modified="2016-10-05" version="1">MSDLFETQNEVTQNDCDTYAQNLVKGFVTPMPWQGFHSYTLRSNSGLIIQFRSKASPLDSSTAKLAKKVHGHLAPATTYRGLMPNSSVSVWVMEIITGVGYLFTTSTITTAKLDITVTDFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X260</accession>
    <name>A0A194X260_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_708693</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068641.1">
        <property type="nucleotide sequence ID" value="XM_018217700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X260"/>
    <dbReference type="GeneID" id="28827426"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708693"/>
    <dbReference type="InParanoid" id="A0A194X260"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267792" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="228" mass="23845" checksum="229569ADA77348B5" modified="2016-10-05" version="1">MQLFTILLASASVVHAHYNFNALIYAGSTQATWQQVRKRSDSDSHGPILDVSLLDIRCGKDASTAFAPGILTVAAGDSLGFAVDPDIQHPGPAMGYLAKVPAGKTAANWDGAGAVWFKVWEQGPTALNSNGGRIGLKALNFTIPKATPSGDYIARIEHIGLHAASQKNGAQFYLSCSQVTVTGGGSGTPSPLVSFPGAYSATDPGILIQIYYPVPTTYTIPGPKVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2P8</accession>
    <name>A0A194X2P8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_555458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068813.1">
        <property type="nucleotide sequence ID" value="XM_018208361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2P8"/>
    <dbReference type="STRING" id="149040.A0A194X2P8"/>
    <dbReference type="GeneID" id="28818087"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_555458"/>
    <dbReference type="InParanoid" id="A0A194X2P8"/>
    <dbReference type="OrthoDB" id="3519926at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="25699" checksum="17B99E8E68198682" modified="2016-10-05" version="1" fragment="single">ELQLSCSVKTLKRRCKEAGYYSCICCQKPYLTKTQANARWLWGIAHMFWTIWEWSQILYSDEVTFQVGGKKYKQRCIRNKKERCHPDCIQFQMHRGGTIPVHFFGAVGYGYKSPLINIHGTRKSGAFTQTDYLAQFMEDGNSAHGHKTTSNICATWRTSMGITLFPHPAVSPDMNPIEKCWRRIKQALHRRLRQPTTEVQMVVAVLEEWDKIPQEWINGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2V3</accession>
    <name>A0A194X2V3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_736548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068870.1">
        <property type="nucleotide sequence ID" value="XM_018220137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2V3"/>
    <dbReference type="GeneID" id="28829863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736548"/>
    <dbReference type="InParanoid" id="A0A194X2V3"/>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21144" checksum="4F52936EE7CB0FCD" modified="2016-10-05" version="1">MSSQIEELIPLTVAKGSTMRTFIDHSKPDESPEHNWVEVVYDGKEDSEVFAIPNHWHKYHDEIMEVLEGRMIFYLDGKELVTSAGDPPLFIARGHIHGFTAIKGERVRFTERTQPAGTFKATFFQDLLQLQRLPGFLLIMRVFYDGDTYPSLPGGFKTLDYIFITLVGLIAKPFVPATPATLKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X579</accession>
    <name>A0A194X579_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain/Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_698165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069695.1">
        <property type="nucleotide sequence ID" value="XM_018216961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X579"/>
    <dbReference type="STRING" id="149040.A0A194X579"/>
    <dbReference type="GeneID" id="28826687"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698165"/>
    <dbReference type="InParanoid" id="A0A194X579"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="96"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="368" mass="39608" checksum="679E498B87EB6EFE" modified="2016-10-05" version="1">MSTSLDTGSVAKDDLHKNGQPSTSLNGGGGYRVPGRADNPLVNVQPPKREDLQPSYAQMLGESDTGAHGWYGSMIDTLGSCLGTMGAIPCCVICPNPYKPVSQGNVGLVTKFGRFYRAVDPGLVRINPLSERLIQVDVKIQIVEVPKQVCMTKDNVTLHLTSVIYYHITSPHKAAFGISNVRQALVERTQTTLRHVVGARVLQDVIERREEIAQSIGEIIEDVASGWGVQVESMLIKDIIFSNELQDSLSMAAQSKRIGESKVIAARAEVESAKLMRQAADILSSAPAMQIRYLEAMQAMAKTANSKVIFLPSASTAGAQMNLAGSFGEGSEHNGLSAAQKYDNNHGDFGGQDSGFQRAINAHVVENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6B3</accession>
    <name>A0A194X6B3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_719919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069707.1">
        <property type="nucleotide sequence ID" value="XM_018218532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6B3"/>
    <dbReference type="GeneID" id="28828258"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719919"/>
    <dbReference type="InParanoid" id="A0A194X6B3"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="166" mass="17763" checksum="AA4699C39A781FBA" modified="2016-10-05" version="1">MDTEAVGKHSHTYSFIDPEKFKGTLKGKVALVIGAGRGIGRAITIALAQAGASIACVSRTQTEIDQVVEFIIKVFGSQAMAVAADVAMPEAPKVILNKVHALLGAVDMLVNNAGIFRYNTLEHEKDFETWWWVVGGRSQPSRSCGNGACCPAIDVIAEYGNDHIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6E5</accession>
    <name>A0A194X6E5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopropionate ammonia-lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_94304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070100.1">
        <property type="nucleotide sequence ID" value="XM_018223525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6E5"/>
    <dbReference type="STRING" id="149040.A0A194X6E5"/>
    <dbReference type="GeneID" id="28833251"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_94304"/>
    <dbReference type="InParanoid" id="A0A194X6E5"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="37"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="384" mass="40599" checksum="39A44104F0B5654D" modified="2016-10-05" version="1">MPSSIFINQLYRPPSSSSPETLPSPNTGVRAFHQSLPGYKPSPLVSVPAIAARQGIRWCLVKDETERLGLPAFKILGASWATYRALGERLGLRENGDVVSLQRLAEAAKAEGVVLFAATDGNHGRAVARMAGYLGVGARIYVPSLLDEEAISKIRGEGAEVVVYDGDYDQTVLATKVAAENHAEGKGVLISDTALTVDDETANWIVEGYQTMFDEMEEQVLEITGTRTITHVVTPVGVGSLTQAVVTHFQRTPRSPKPMVIAVEPKSAACLKASLEAGEMTSVKTEYTICTGMCCGTLSAIGWPMLKSGISAAVAVEDSDVDTATKNLQSCGINAGPCGAASLAALESLSSGEELALGPQSVVVLLCTEGRRGYEMRSNSQPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6H2</accession>
    <name>A0A194X6H2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069762.1">
        <property type="nucleotide sequence ID" value="XM_018222695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6H2"/>
    <dbReference type="GeneID" id="28832421"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783561"/>
    <dbReference type="InParanoid" id="A0A194X6H2"/>
    <dbReference type="OrthoDB" id="10617051at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14292" checksum="09552F4230F5E5F8" modified="2016-10-05" version="1">MPLSPASTHITHGTSTESPPDNSSACTSNSNLKSSLAKNITSLPLPTSTNDSTLPDPNIRTSPSLLIVLPTSRTISERQKLCSGRVNSYFADPIHTLPQYKRNTIQAGMKDHVEDMLSQVEALTMKINEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X875</accession>
    <name>A0A194X875_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_79868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070669.1">
        <property type="nucleotide sequence ID" value="XM_018223411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X875"/>
    <dbReference type="STRING" id="149040.A0A194X875"/>
    <dbReference type="GeneID" id="28833137"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_79868"/>
    <dbReference type="InParanoid" id="A0A194X875"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="37012" checksum="DDAD6F6EE600B232" modified="2016-10-05" version="1">MVIAVTPSFFCFLLAVCGYYILKGLGILFRRHRTDDLLQFVIKLFVVAALVVYNYSLMGLGIGGIGISWKKQMKNSCQGFDTRVNLDIYIKGDGNPHFPSHKLSLYTPDLPNPPPHQLGIDDFEFTSPIDSSKSPSEPYHTYHRMTGTLSPSQHLAIDFDLPNHLWRIMNLTYTDPSLNPTTSFPGTARTLFKSGTWSPTNETNPHAFIPELSLQIPNLYYYTRHCAYQPFMKVYTTTNLNATQITEQGNRTWSPLNEKEVVMRTAAFGYLPEKLEVCARRNEYEVNGTKMHGLREDVVVPLGLLAALRLQMRADGKFERGCEYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X892</accession>
    <name>A0A194X892_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_748912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070689.1">
        <property type="nucleotide sequence ID" value="XM_018221161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X892"/>
    <dbReference type="GeneID" id="28830887"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_748912"/>
    <dbReference type="InParanoid" id="A0A194X892"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="27934" checksum="24DAC79F5CEDC853" modified="2016-10-05" version="1">MVDISHIIKISSYSQSFPKRFLLEARMKAEKKMRCPPKCTLCYWMAAHTADEGFAHRQKENLIRNERVYESVLCNERLAIILTYNQQETQFASLRALAQNERDSCDRDVQKLAVIASATHRSFDEQITQVQKKMEGASDSYIELYGYRLRRELMYLKKQQKDEDESYERLFSSMAENDHRNIIDMEEDAEDRIREIKDDYRCAIEQLDDLLEPVREQIQILEWSVQEKILSVMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8A8</accession>
    <name>A0A194X8A8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_734497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070756.1">
        <property type="nucleotide sequence ID" value="XM_018219913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8A8"/>
    <dbReference type="GeneID" id="28829639"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734497"/>
    <dbReference type="InParanoid" id="A0A194X8A8"/>
    <dbReference type="OrthoDB" id="3479218at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="57196" checksum="009B059B080AC4AD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9D7</accession>
    <name>A0A194X9D7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_782016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071089.1">
        <property type="nucleotide sequence ID" value="XM_018222538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9D7"/>
    <dbReference type="GeneID" id="28832264"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782016"/>
    <dbReference type="InParanoid" id="A0A194X9D7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="52292" checksum="B56BCD8A6E543FD4" modified="2016-10-05" version="1">MDKSSINTDTDGASPTEAIHVETPDPETSKRLVWKLDLIVLPLLAIIYFTHSLDRANLGNAKTDGFEKDIGLKDNQYSLILILFYIPYGTLNIPATVLAKRYSPAVVIPCLMFCWGTIAASTAAVHNFGGILAARICLGVVEAGFFPSAIFYLTMFYTRTEIAKRISLFYMMGFVANAFSGLIAYSVFQWHRSLYNWQYLFIIEGSLTVTLAILAFILLPRSIAKSNYFTEAEKQCSKLRLQAESEIEGDSFSWSATLTPLLDWHSWMYGFMALCYGCAAASISNFLPTIVKRITVNTVKANLYTVAPNLSGGVFIVLICWLSDKTQQRALCAIGAVAISMIGFICLGTVDITHKTRLGYFFTFLLTFGSFTPAVLVPAWLSSNSISTSGRATTVGLVAGLQNIAGIISSESFRSQDAPIYAPALIISGCFEGAMCVTAAFAYLYYRTINRRLDSGKMQFVRGMEQNPNFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9X3</accession>
    <name>A0A194X9X3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biotrophy-associated secreted protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_707360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071325.1">
        <property type="nucleotide sequence ID" value="XM_018217602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9X3"/>
    <dbReference type="GeneID" id="28827328"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707360"/>
    <dbReference type="InParanoid" id="A0A194X9X3"/>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267989" description="Biotrophy-associated secreted protein 2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="25456" checksum="D97DE06A1C990982" modified="2016-10-05" version="1">MKAFTIAALFNFSLLVSAVPPFDPAGAKNVGNGAGVQFIGGQCLSDADCQSACCANPTGICSGPGASTQNGKTGCGFGGSSSSSAVVAVSSAVAGANIAAASGTSAASTTPANGGPAFDPAGAKNVGNGAGQQFIGGQCLSGADCQSTCCAGPSGICSGLGAQTQAGKTGCGFVSGSASNAGADTASSASAAAPVASSTSAASTASKGGPAFDPAGAKNVGNGQGTQFIGGQCLSGADCQSTCCAGPSGICSGLGAQTQAGKTGCGFVSSAKLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA38</accession>
    <name>A0A194XA38_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_718732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071393.1">
        <property type="nucleotide sequence ID" value="XM_018218438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA38"/>
    <dbReference type="GeneID" id="28828164"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718732"/>
    <dbReference type="InParanoid" id="A0A194XA38"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27808" checksum="B8B7EB63E6BCF67C" modified="2016-10-05" version="1">MSTSTSQPEGISIADELGLDTVKLIVGSGDQKCSFAVHKNPLCKKIPYFDTMLHSKFKEALTDQAEFQEDLPVAFRILINWIYQRKVKALPPSDPRSGGLSQALQLLQLCILAEKLMATQLLDDALAALSKQYMYTYATSPENSNPFEVTPAELCGVYNELPEHSKVRTWVVRVIAHQFSIIRRKDYNNSAFQELLADNFDPLGEFLTGLRMDKHENSDISAYLYAMPPPNHYPSNLYYALPTQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAJ8</accession>
    <name>A0A194XAJ8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_734174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071546.1">
        <property type="nucleotide sequence ID" value="XM_018219883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAJ8"/>
    <dbReference type="GeneID" id="28829609"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734174"/>
    <dbReference type="InParanoid" id="A0A194XAJ8"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="123"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="408" mass="45438" checksum="DF53A3206561CEB8" modified="2016-10-05" version="1">METIVGARGPDGPDISIAGPMMRTIWILYGITFAVVILRLYTQWRITCSLGLGDAIMALSLLCGTGILTTLTIQHHYGLGRHFSYLDPHQKVEALYFNFIGQPLGRHSLLRERSIQQHILNFTGIMAAAFVCKDPRTLWDPIGHPGYCWRPFIQEYTGFAQGAINSATDLFLTILPIRIFYTLKMSIHLKLGLGFLLGLSAFAFVASIIKTVELKAIGNRGDFTFGTVDFFTWVIVEFTLVDIAASAPLALPLFRRLRKPPPKNSYQLQKPYGGHSIVILGGKSAHPQNRNKSRSKLAINDLETTILNSSEDNILTLVDDAGERAGERDLPRAAGRAVDLESGARKKVTSPVCDGKTAIIKQTSFDVSFKVNEGEGVNIDGTRRRDEMWMTKELPKIPWEAQVKMYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAR4</accession>
    <name>A0A194XAR4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_554243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071584.1">
        <property type="nucleotide sequence ID" value="XM_018208345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAR4"/>
    <dbReference type="GeneID" id="28818071"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_554243"/>
    <dbReference type="InParanoid" id="A0A194XAR4"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="1">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="435" mass="47717" checksum="1EA033012331F1B8" modified="2016-10-05" version="1" fragment="single">QYEIEGYPTIMFFDGSGNQPEKYRTMRDLDSLTEFLEDKTGIRVADGAHIPKPSGVPPPINMSSKPSISQVRAIQARPAPMAAPPSGCLLCRDFSGPDGVAAQYPRQSLPRGPDMTGYLADVLCSPFSSATDKARAIFTWLHHNIAYDTVAFFGKNVKHVDPKDTITSGLAVCAGYAGLFSAIALKAGLEAVMVTGHGKGYGYTALKPGEPVPPANPSGHAWNAVRIDGGEWKLLDACWGAGNVGNQVYNKHFTPSYFTMSNDQFGLKHFPQDDKYFFHSDGQIPTWEEYYLGPTPAEPLQLFGSVEDHGLSATSFTPQQKQIPVNSNEVIRFQFSKVCEHWDHEKNGKGKPYCLIIKIWGLDGRKEDFVAMENNDFWWWADISARDLGAPGQTVICYAVTTVNGKDARGMSRGEYLHKKGKCGMGFGGVSAWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBX1</accession>
    <name>A0A194XBX1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_707125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072015.1">
        <property type="nucleotide sequence ID" value="XM_018217579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBX1"/>
    <dbReference type="GeneID" id="28827305"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707125"/>
    <dbReference type="InParanoid" id="A0A194XBX1"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="480" mass="54377" checksum="649361831F1DD1F9" modified="2016-10-05" version="1">MRTSLRRSCNACVKAKHRCDLQIPQCSRCMKRKSRCLYTNEPAPSRPHDTSTGTSGTRKLALENEFDVSSATGRNVRVTPRRFESLVRLENPSNEYLDPFSVYPATRLPRTHVQRLIHHFLSNIAFQYYPLDLNADSNPFLVSWWPLALQDPALFHVSLQTASLDEEVRAQKGFPISELLMVDSVSLVRRKIEDSSLAFQDETLNSVVTLAAIEHGKGHIQASRMHIDGVKRIVDVRGGIDKVKCSSPLTARMVLWVSLLVTGTPQFQTQDDSGDRTGIGPIPQWHLASKDTPSQQLTLDHLDINPVMSNILSHLRNIFHDPHLSNLTTTELHDLTCYVVHKLLLLPPFSTVDTKQSSTSECLRYALALYMLIIHGTTYYSHVDIENAIMVQLKTNLKTLIWTNDFDSLKLWFISIGMAAAGDTADHQWFLDQACIATTALGLQVWDDVLLRLQSILWIRMQQGALFQQRWEEVLISLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCG4</accession>
    <name>A0A194XCG4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_780994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072215.1">
        <property type="nucleotide sequence ID" value="XM_018222438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCG4"/>
    <dbReference type="GeneID" id="28832164"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780994"/>
    <dbReference type="InParanoid" id="A0A194XCG4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17429" checksum="4899DE277974A64C" modified="2016-10-05" version="1">MRLWMLQTNTTRIMHRVCVPHRALAYLLPPLYEIYRLELCIATTSTLQTTPPRSLQAIISHQLCKRHLLERCKPSHHIYSANNTSSNSTYYIVMNSFVGGGLPWEMENIDQLDAVKQSQFCGWIRSWYGGNWKTTLWVAAIMDQASAFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCY5</accession>
    <name>A0A194XCY5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_733456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071972.1">
        <property type="nucleotide sequence ID" value="XM_018219800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCY5"/>
    <dbReference type="GeneID" id="28829526"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733456"/>
    <dbReference type="InParanoid" id="A0A194XCY5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="32898" checksum="53F8691FD217CF3B" modified="2016-10-05" version="1">MEDTSQSRLQTAEESYSSMNLSNNNRSVKQRLSVELNDKNDLEIEFEARLDALKEENQQMRDRSTSQEAVLTAKSQQIKALQAGTSAQLEKAIKKSQGLSNGIKAAGVSNAASANDVIALKSKLEVHIDKIHTLEEEVEELNNEKRALDKGNKSLGASVLLQLRELDGMRRDLAASKHDLGIAKSAVLATLKKLSMARRALATVRSRYAIMHMRMREVKKSATQSLGKAKRWIRALEDQNLEAKRSPFRFIIVCLIGKIRAWKLVQVLFAKWSRMRSGTRAVDGPNEQYPLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDG6</accession>
    <name>A0A194XDG6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LY89DRAFT_781300</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072575.1">
        <property type="nucleotide sequence ID" value="XM_018222471.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDG6"/>
    <dbReference type="GeneID" id="28832197"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781300"/>
    <dbReference type="InParanoid" id="A0A194XDG6"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
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            <end position="115"/>
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            <name>[2Fe-2S] cluster</name>
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        <location>
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        </ligand>
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        <location>
            <position position="390"/>
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            <position position="791"/>
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            <name>Mo</name>
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    <sequence length="1370" mass="150396" checksum="ECDFDD8295D10D6E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF92</accession>
    <name>A0A194XF92_MOLSC</name>
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        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073264.1">
        <property type="nucleotide sequence ID" value="XM_018222429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFJ7"/>
    <dbReference type="STRING" id="149040.A0A194XFJ7"/>
    <dbReference type="GeneID" id="28832155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780886"/>
    <dbReference type="InParanoid" id="A0A194XFJ7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268173" evidence="3">
        <location>
            <begin position="21"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="623" mass="67066" checksum="BA2D5822483CCC47" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFR9</accession>
    <name>A0A194XFR9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_643546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073329.1">
        <property type="nucleotide sequence ID" value="XM_018211799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFR9"/>
    <dbReference type="FunCoup" id="A0A194XFR9">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFR9"/>
    <dbReference type="GeneID" id="28821525"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643546"/>
    <dbReference type="InParanoid" id="A0A194XFR9"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ18974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136697" checksum="119130517AEC65C5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG55</accession>
    <name>A0A194XG55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_612583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ19109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073464.1">
        <property type="nucleotide sequence ID" value="XM_018210626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG55"/>
    <dbReference type="STRING" id="149040.A0A194XG55"/>
    <dbReference type="GeneID" id="28820352"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612583"/>
    <dbReference type="InParanoid" id="A0A194XG55"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="210"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="414"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="586" mass="62817" checksum="F6B2A8C36668983B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGE0</accession>
    <name>A0A194XGE0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_706466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073197.1">
        <property type="nucleotide sequence ID" value="XM_018217531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGE0"/>
    <dbReference type="GeneID" id="28827257"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706466"/>
    <dbReference type="InParanoid" id="A0A194XGE0"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="668" mass="76508" checksum="26184EB74CD43B13" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGH7</accession>
    <name>A0A194XGH7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_485995</name>
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    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073594.1">
        <property type="nucleotide sequence ID" value="XM_018207851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGH7"/>
    <dbReference type="GeneID" id="28817577"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_485995"/>
    <dbReference type="InParanoid" id="A0A194XGH7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8274" checksum="4109839BB54559F0" modified="2016-10-05" version="1">MFMYEAQSVAGHDLIPPPQQTPALYSSEQTWGTYDSHTQNLLQILPYALCIMVSASALCIIISRSSTIGSRREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGJ6</accession>
    <name>A0A194XGJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_775108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073252.1">
        <property type="nucleotide sequence ID" value="XM_018221983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGJ6"/>
    <dbReference type="STRING" id="149040.A0A194XGJ6"/>
    <dbReference type="GeneID" id="28831709"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_775108"/>
    <dbReference type="InParanoid" id="A0A194XGJ6"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="39910" checksum="5E977F23AED9F61D" modified="2016-10-05" version="1">MIMTGSQQVDMQQIEIVEQTKHELLVANIFDKALANNIDDGHDQVATAVSEIIQLFPSSGSTEEMESYLWNLWGTLIQKAQEVPRHDERQRTLVRIVTTLRDQTPVGDSNSITVWGSNYTLWTDLPLLGPCMREAWIAPPGFFRGQIISATSLEDEDDAGERDLSHNEDNTTKEIASEDEDNTAEGIAPDEDHTEEELESWINLNAFAAQLLEHRTMLWANLGLWQLRTALERNGDFVESRIIVASEWIRHAGLQIFDLCFYDVADEDSRNAMAPGPLISQEKGGFTRFRWNYWNGRFWKASEFGGSRSRSATEAATEAATEAATTMQLIPSSRIQGPNLLGHDPNLMLRIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH72</accession>
    <name>A0A194XH72_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_780438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073868.1">
        <property type="nucleotide sequence ID" value="XM_018222382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH72"/>
    <dbReference type="GeneID" id="28832108"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780438"/>
    <dbReference type="InParanoid" id="A0A194XH72"/>
    <dbReference type="OrthoDB" id="3921745at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="397" mass="45801" checksum="4EEC4753B8AC4302" modified="2016-10-05" version="1">MAATRNRMDIVAMLNPTGEDLEMPHVEVEVTTISYDSIHPKPMPVEIGGCYVQPYPTPRNSPVQQHSTPSSIFYNAPQLGPLPSVNHLLGYPSPPPSSEACLPSKTYPPAQTSNGFVKPYVHARHVEQYYTATSCPEYDSYSRRSTRRERDSLRRASRTPPPTPVPAYVEARKQLLVLAQVQASPKKGPSHSNEAYRLIHVHWTRYCKVDMKAGWHAIEHNFKIMFPNEREDCTPGGLSSRYYRDNFIPRLDLHGNVIYKDGKPLMMDMKVRGKDMGECKGCPWTFVERHPWWALKYDWVLQEHKIEAAKIIADIEKRRPGQYSRKQQYVLAIREVESKREAARESKRNGTFSEPLLDDEEFESIPSPTEEEIKEIEDDERYVENLYKEASQQEFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHM1</accession>
    <name>A0A194XHM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome P450 pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_695873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073627.1">
        <property type="nucleotide sequence ID" value="XM_018216790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHM1"/>
    <dbReference type="GeneID" id="28826516"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695873"/>
    <dbReference type="InParanoid" id="A0A194XHM1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="441" mass="49555" checksum="054AE7B85BE51C57" modified="2016-10-05" version="1">MADSSFIVLLFQLFKSNLVLIVFTFIIKHLLRNKYGSGISHIPGPSLAAWTDLWRVNNVRKGKSHMTMIELHKKYGKLVRTAPNVIDVSDAAEIPKIYDIKGAFYLILSVLWKGKAQMSLFSSRDQVYHRELKRKAGNMYSMTSLLEMEDSIDECTALFVKILGELADKGEAMDLGAWLQYYAFDVIGEISFNKKFGFLEKGGDLDDMMATIDGILFYSTVIGQVPYLHPFLLGNPLLPVFVPQVESWNHVVNFTVQAMKARSDSGSPKKETSKDMLSRCLSANLSEDDILILLSTNVFAGSDTTAIALRSTIYHLLKNPSCLSTVLEELDANSHRLSSFITYKESKDYLPYMNAALKEGMRVHPSVGLLLERYVPKGGATICGAYIPEGTTVGINAWTVHFDEKVFEDPESFRPERWLTRDEKKLAEMEKSFFSFGAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHZ2</accession>
    <name>A0A194XHZ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_731786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073742.1">
        <property type="nucleotide sequence ID" value="XM_018219619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHZ2"/>
    <dbReference type="GeneID" id="28829345"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731786"/>
    <dbReference type="InParanoid" id="A0A194XHZ2"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ19387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="359" mass="40445" checksum="EB42ADAD3F34901C" modified="2016-10-05" version="1">MVVGEQMTTDDAGLMGFGDTSLIPLRPFPFISEDMTLSDPLLWTLPYWPSEPAGSGTRIPASELTLIEDEENPLKDKLSRIRDRWINPSFKPPSRILQVHGASAAFLTHVLKCYPKMMARDGSVPPMIHRLQLTSRTAFVPLVNCLAWTKIWEHRTGSDEAVLLNAMQGELEKLYQEHHLYGQADLLAALQASLIYSIIIYLESNMTVKYAAQVLLGQLQEMAYHLLITVTIPKARPSGAVLDQESWVITSAAHRTVLAVYIFEYVICLLNSLPVYSCNELDSIPAPVCGRLWEAQGYGTWRDEYGNWAKMWKGREVVMAELLDRQVESYAYNRVEKWLSEADEFGMLIFTGSLISAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI18</accession>
    <name>A0A194XI18_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_731810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073767.1">
        <property type="nucleotide sequence ID" value="XM_018219621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI18"/>
    <dbReference type="GeneID" id="28829347"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731810"/>
    <dbReference type="InParanoid" id="A0A194XI18"/>
    <dbReference type="OrthoDB" id="3514788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="402" mass="44230" checksum="3A7858FF94E47C32" modified="2016-10-05" version="1">MTVSVSDFPAGTPNRLSLRIGCYILFGVCTATLFVRFYVRAFISRKFGLDDLLITLSWMAEVVHIVCVKLQFENGTGWHVADLAMLPNGVAVINGMILWPWITQALYYFGLGCIKASIVALYLRLAVTPLQRNILWGMLIFVLAQGLSSTIVVAGFLCTPLSQVWTTPTAIGGPTCINILTFNYYNAALFIITDIFLALAPLAVIKNLQMDVKRKRALGIMFSLGVLAIGGTIARQVTNAIAINNTSDFTWHWAPTALCSILESSLGIVFVCVPAMAPLFKNWVGGGSSAKYTPNNYQSDRPSTFGKLRNKPKLRPDDESILCTTQITAVDRKDRDGAVESYEMDQQTGNYIGDGGSERRIITPPTYREQNGKKENECDGKSGVMVNVEYQVNRSHRKSGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI77</accession>
    <name>A0A194XI77_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_466350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074280.1">
        <property type="nucleotide sequence ID" value="XM_018207719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI77"/>
    <dbReference type="STRING" id="149040.A0A194XI77"/>
    <dbReference type="GeneID" id="28817445"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_466350"/>
    <dbReference type="InParanoid" id="A0A194XI77"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="598" mass="66493" checksum="7738C588AE79BD66" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIQ5</accession>
    <name>A0A194XIQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transport protein SEC61 alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_469649</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074398.1">
        <property type="nucleotide sequence ID" value="XM_018207745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIQ5"/>
    <dbReference type="FunCoup" id="A0A194XIQ5">
        <property type="interactions" value="938"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIQ5"/>
    <dbReference type="GeneID" id="28817471"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_469649"/>
    <dbReference type="InParanoid" id="A0A194XIQ5"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="Plug_translocon"/>
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        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
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    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ20043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="468" mass="51372" checksum="1A05794D3C5AF18A" modified="2016-10-05" version="1">MSGLRFLDLIKPFTPILPEVQQPETKVPFNQKLMWTGLTLLIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGISPIISSGMIFQLLAGTHLIDVNLDLKSDRELYQTAQKLFAIILSMGQATVYVFTGLYGQPSDLGAGVVFLLILQLVVAGVIVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAVIALFHLLLTWPNKQRALQEAFYRQNLPNVMNLLATLVVFAAVIYLQGFRVEIPVKSSRQRGARGSYPIRLFYTSNMPIMLQSALSSNVFLISQMLYSRFADNLLVQLFGVWEPREGSAQLFAVSGLAYYMSPPLNFTEALLDPIHTAVYIIYMLVACAVFSKTWIEVSGSSPRDVAKQLKDQGLVMAGHREQSMYKELKRIIPTAAAFGGACIGALSVASDLLGALGSGTGILLAVTIIYGYFEIAAKEGDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ85</accession>
    <name>A0A194XJ85_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative elongation factor 1-gamma 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_579731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ20218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018209023.1"/>
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJ85"/>
    <dbReference type="GeneID" id="28818749"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579731"/>
    <dbReference type="InParanoid" id="A0A194XJ85"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
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        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
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    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="270"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="430" mass="48853" checksum="EDF8C9F9500058AB" modified="2016-10-05" version="1">MAPFGKLYTYPGNPRSTAIRAVAKANNVDLEIVETEPAKGVSAEYLKINKLGKVPTFVGADGYTLHECIAIAIYSTWKLFTPLTFLSRLTSQNEKTTLLGKTKQDYASILKWMSYFNAEVLPTLGGWFRPLIGRDPYNKKNVEDASKAALKAVGVVEEHLLHNTYLAGERITLADLFAAGIISRGFQFFFDKQWRAQNPNVTRWYETVYNQPIYSAVVDKLSFIDEAIKYTPPKKEAASKKEAAPKAAPKPKAKEVEDEEEEEVQEAPKPKHPLEALPKATLPLDEWKRQYSNNDTPDALKWFWENFKADEYSLWKVDYKYNDELTQIFMTSNLIGGFFARLEGSRKYIFGCASVYGVKDDSVIQGAFVIRGQEALPAFDVAPDYESYEFTKLDASKPEDREFVNEQWTWEKPITVGGKEYPWADGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK90</accession>
    <name>A0A194XK90_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMPKBI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_474131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074562.1">
        <property type="nucleotide sequence ID" value="XM_018207792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK90"/>
    <dbReference type="FunCoup" id="A0A194XK90">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XK90"/>
    <dbReference type="GeneID" id="28817518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_474131"/>
    <dbReference type="InParanoid" id="A0A194XK90"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="359"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="469" mass="50770" checksum="92D79937D9915178" modified="2016-10-05" version="1">MGNNPSTNNRPSHQASPSPSHDSSRTSSTRRNPRNLIQAQRAPAEPSMAQARGTTTATHRTRNSQSHSTAAPFSTSSPSQSVNSPSYHSSDSQMGAQISKDEPKVEVRDQPSKPVDVPAPTAMNIESASTRSYSQSIEPSGPPLTQDMSYHLTRPPRLPLPIEEEVHTPGSPIIAPADVDAPALDIESLDHETLPRRSSALSNTTIDEEDAEELRVDKTGATVPTTFEWQQGGEKVYVTGTIFQWNKKHRLHPVPGKPGLLRAVIHVRPGTHHIRFIVDGLMQCSTLLPTTVDFGNNLVNYIEVSADDLPREVPVAVEGTGTPVSNVQAQAQTPPKNAEPKANVEPHATKVKVPPRTKPVIPVGKFSSQIPQYLVDLDKAEDSAAYQYAAAAIEKLPTPPSLPGFLGKPILNAATPMKDDNSVLTMPNHTVLNHLATSSIKNNVLAVSATTRYKRKYVTTIMYKPTGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKD4</accession>
    <name>A0A194XKD4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_705440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074924.1">
        <property type="nucleotide sequence ID" value="XM_018217451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKD4"/>
    <dbReference type="FunCoup" id="A0A194XKD4">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKD4"/>
    <dbReference type="GeneID" id="28827177"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705440"/>
    <dbReference type="InParanoid" id="A0A194XKD4"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="23104" checksum="1AA954B7D3A665D9" modified="2016-10-05" version="1">MTSNHDPSILSPDRTLPPSNPPSQKTFPFPRDYHFPPYFTRQPTLTTRHAQLQKWSSLILSYCRYHKIWKLSLADAIESDLFWNKKLGKRLSREDAREVLEFMRKEGRSEAVGGKDGSVFWVWWRDPEEWAGLIADWVDDTAQKNTVLTLYELTESEATLSQDFHGMDPDLLQKALSILVKRGKAQVFGQEDQQGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKI2</accession>
    <name>A0A194XKI2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075075.1">
        <property type="nucleotide sequence ID" value="XM_018214506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKI2"/>
    <dbReference type="STRING" id="149040.A0A194XKI2"/>
    <dbReference type="GeneID" id="28824232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682414"/>
    <dbReference type="InParanoid" id="A0A194XKI2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="507" mass="55725" checksum="668DB46D0BB66430" modified="2016-10-05" version="1">MASQSSVEEVATPIENPVTPQADDIDLPSKVDLNHPASLTTSMLVAGSSSAMRPSSITPPPSSQAPPRVAPRSITPDASAAGAMSSPPPTVNGHKREVASAGPNVEELAQYTKQELIEMVEKAKAENHKLDAEASEARMSAAHYKLQYRLLTIESEEALKRMEVEHDITRREVEVLQGTGRESTNIEYTQKLKAYCKSLEDDLYAAHRRIEKAKRLIESKEDQIVDAKEEIGRLHERIRQNREHINVLRSPGGPLHVGTPKAPATPHQYQRGTPRYTPSSNRQVRYPASQDNQERFNALLLAGSVLSQENNSAPSTPTIARRPDPRTPNKHNRGVQSLSSFPTTPGSGRPITANSTLLPAPEFSQNTERINVLAHNALQHMNQTEHRRRKSRDSTISASDHEEIVRATNASYREESDEEVQESQASQSATEMLRADPRESFEVAASRTHTPVPGDKAKVNLQSKLFAPISKGGAEKRKRDEEYGPVKKARSDGEAIGLGIGFESGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL11</accession>
    <name>A0A194XL11_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_682460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018214517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL11"/>
    <dbReference type="STRING" id="149040.A0A194XL11"/>
    <dbReference type="GeneID" id="28824243"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682460"/>
    <dbReference type="InParanoid" id="A0A194XL11"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="58266" checksum="B3D9FC179BAF177E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLB6</accession>
    <name>A0A194XLB6_MOLSC</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_681558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075276.1">
        <property type="nucleotide sequence ID" value="XM_018214322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLB6"/>
    <dbReference type="STRING" id="149040.A0A194XLB6"/>
    <dbReference type="GeneID" id="28824048"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681558"/>
    <dbReference type="InParanoid" id="A0A194XLB6"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
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            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="693" mass="77899" checksum="4D3DEF93654245FB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM12</accession>
    <name>A0A194XM12_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_730071</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018219436.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28829162"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730071"/>
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    <dbReference type="OrthoDB" id="3478025at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28048" checksum="AB207E86CDA4B219" modified="2016-10-05" version="1">MGMQSSVDDLLVWTKAVMREDMEAEQCPDQVYNHPSILRGATVARLPFFQTWSRDDVNSWAYCMGWTKTKMPTSRFGALSYNFAAQDHRFAQPEKYIIGGNDTTNRTILQCNGTVNGSNCGLYTFPETESAIMVCCNGLTNGDAADWAARILTQALFNLQPRIDFLELARIEADARNAHYQAMLTEWHSNYDPVPQSVADVLRFVGIYNGMATSLTITSRTKTYDADPASLSSPASDSDRSSLGLHVVFNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMW8</accession>
    <name>A0A194XMW8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_779023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KUJ21503.1"/>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_779023"/>
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    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="340" mass="37590" checksum="1AA742524F24FE8A" modified="2016-10-05" version="1">MSLPRLLLDLSTDLPPTRDHPAHPSSLPTATSIKAHPTNPGSENASIFFVGTATTILEWEGVRLMTDPNFLHKGDHVHLGPGVTGTRETNPAVNLHELPRIDVVLLSHYHADHFDQDVEASLRRSLPIITTPHAKSHLAHKAGENEAFTAVHELDTFQSMMVDIKPASQEQKPNKVPAMKVTAMPGKHVPPGVLGTMNDLMKAVPPTNGWMLELGYNTDAEFSCGYRIYISGDTLMVDELEEIPERYAGQNIDLMLIHLGGTTIPSPKLPLLMVTMDAKQGLQLVQLINPDLTIPVHYDDYDVFLSPLEDFKKVMDEAGLSDKVVYLDRKDQYKFAVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNK8</accession>
    <name>A0A194XNK8_MOLSC</name>
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        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_637576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNK8"/>
    <dbReference type="FunCoup" id="A0A194XNK8">
        <property type="interactions" value="1143"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNK8"/>
    <dbReference type="GeneID" id="28821263"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637576"/>
    <dbReference type="InParanoid" id="A0A194XNK8"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="551"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="700"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ21694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="753" mass="83959" checksum="DF4E116B0C8EF04C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNR1</accession>
    <name>A0A194XNR1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_608208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076104.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNR1"/>
    <dbReference type="STRING" id="149040.A0A194XNR1"/>
    <dbReference type="GeneID" id="28820215"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_608208"/>
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    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="338" mass="37566" checksum="203DBF5CC00CB174" modified="2016-10-05" version="1">MANSLDATAPVYLRHFSFFQRLYYGIRIRVMKSLATAFFSLFRLPGVRDNSILPTYTTVYPCQPKLTNRVFFPKSYKPDDAPLPLYLDIHGGGFALMSPCVDDWFCTEFCNDNKLLVISLDYPKTPAHPYPAGVQAIADLVDAILKDESLPFDRKKVAIGGFSAGATLSLAAPQDARLKGKIGGVAAFYPPTNWTTSIDWKLSTRPKDAGPDGLKSQAGMFDYAYFKPDQNLKDPQASVAFASRESLPPKLCIVGCEFDMLCRDSELMAESLAKVGNGPRTGTDTAWEQNGVRWEKVLKEVHGFDLIPARGEEKARTKARGKKMHQDAAEFLLREVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP93</accession>
    <name>A0A194XP93_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_388370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076254.1">
        <property type="nucleotide sequence ID" value="XM_018207164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP93"/>
    <dbReference type="FunCoup" id="A0A194XP93">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP93"/>
    <dbReference type="GeneID" id="28816890"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_388370"/>
    <dbReference type="InParanoid" id="A0A194XP93"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000697">
        <property type="entry name" value="WD repeat protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="744" mass="81895" checksum="6577878A3605FBC7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPN2</accession>
    <name>A0A194XPN2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_391867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076389.1">
        <property type="nucleotide sequence ID" value="XM_018207197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPN2"/>
    <dbReference type="STRING" id="149040.A0A194XPN2"/>
    <dbReference type="GeneID" id="28816923"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_391867"/>
    <dbReference type="InParanoid" id="A0A194XPN2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000014">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ22034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="50542" checksum="D43D05800A382377" modified="2016-10-05" version="1">MMSSYDAQQLYYDGKVQRATSGKTFTTVDPSTAKPLAEVHQAAPADIDAAIASAKKAFPSWSQTPPIIRSRILLKAVELLRSRNDEIAKIETHDTGKAFSETSTVDVVTGADVLEYFANLVASGGLNGETTQLRPDAWIYTKKEALGVCAGIGAWNYPIQIALWKSAPCLAAGNCMVYKPSEVTPLHGQVLAQIFTEAGVPPGVFNIVHGDGAVGGYLTSHPGIAKVSFTGQVSTGQKVAASSAGGMKYVTMELGGKSPLIILPGTEVENAVDGAMMANFFSTGQVCTNGTRVFVPKSMKSSFERLLLEKMSCIRSLAPMDSNSNFGPLVSEIHYKKVLSYIQHGISVDKARLLHGGATKPKTIPAGYENGFWVQPTVFTDCTDTMKITTEEIFGPVLCILPYDTVDEVIARANNTKLGLAAGVFGKDVNKCHEVISKLEAGITWINTWGESPAEMSSTLVEGSGIVGTVFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQI1</accession>
    <name>A0A194XQI1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_299450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076808.1">
        <property type="nucleotide sequence ID" value="XM_018206562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQI1"/>
    <dbReference type="STRING" id="149040.A0A194XQI1"/>
    <dbReference type="GeneID" id="28816288"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_299450"/>
    <dbReference type="InParanoid" id="A0A194XQI1"/>
    <dbReference type="OrthoDB" id="3595805at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="48351" checksum="964F09F7EB2C33D8" modified="2016-10-05" version="1">MTEIKYAIVILSGNPNWIPWKEVTKTTAIEVDVWKYMDPDVNEPTMVPILAEPIKPTPSTIKNDIIITPASTRTATPGTAHSIPTTTPAVTRPAKFSDLDQDEREELRSLREEYAYKMKKYDRQVEALRAMEAHIQNTIDPKLLIYTYNCPNAWKMMHNLKMECAPTDYSRKKTILGKWGKLKSTAKSSTDLEHWLREWHTIYDEGIELKVPELVDTDRACHDFLTAIYPIAPSFSDSKELEMLDDKQPWSFKQLVRQYSQWRRNTSDRPRTTVKNLAYIAKKQDKPQRSNSPASFNGKERADYTQLPCLCGETQSYSDCPYIIPSKRSSTWKADPEIQKQVDDKVENGSFRLKRRIQFLRDQAEQRIKDKAKSDKKTPDKSSTSAKPAVQVAKGDMYVVKTEFQLTLSRAFLARETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQT6</accession>
    <name>A0A194XQT6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_554026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076774.1">
        <property type="nucleotide sequence ID" value="XM_018208340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQT6"/>
    <dbReference type="GeneID" id="28818066"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_554026"/>
    <dbReference type="InParanoid" id="A0A194XQT6"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="120"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="308" mass="33648" checksum="22E82248D61030C7" modified="2016-10-05" version="1" fragment="single">LGPWVRLEGISISQLPPGGKGVEPVNAPSSTEKYSDRSGSIAAPSLTGLITSVLTESIPFINGVAPKDGSTPTWKVKGSPKKYASSEAPVHLSERVVSGKELDKVDGMSQFSADRKDETWFCRRSCHRNAAEKGTASWQEFVHSFKEHHAETEDAFTPTVIGARQAMSWNTNGIEVNVHGGQWTNITLVLEEMKHKIDPKPLKNRTFPVLQLSATLAGAEEFLVVSIPINDFNKSPYAEYAKDKSLVMAAYTSVERIRVLPSNGDIEWIMATASDAGGVLPQWMQNLAVPGAVAKDVEMFLSWIPSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS01</accession>
    <name>A0A194XS01_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_166636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077430.1">
        <property type="nucleotide sequence ID" value="XM_018205533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS01"/>
    <dbReference type="GeneID" id="28815259"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_166636"/>
    <dbReference type="InParanoid" id="A0A194XS01"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="321"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="621" mass="68740" checksum="9EC4B3B9F249D42E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS70</accession>
    <name>A0A194XS70_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_727827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077398.1">
        <property type="nucleotide sequence ID" value="XM_018219198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS70"/>
    <dbReference type="GeneID" id="28828924"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727827"/>
    <dbReference type="InParanoid" id="A0A194XS70"/>
    <dbReference type="OrthoDB" id="3468948at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23164" checksum="245C184DC3BD540B" modified="2016-10-05" version="1">MPAPAQVPVLSFEPRSGQPISNVSVGLDATILRSWRDGSEYGLADPNFPYFAMEIQISGWRSLQNIILARYTGGKLKKDALYQLKGRFFVDTTSREAGKSYFHVDEAIRFQGPGTIRSFKKPQFMMVGEVVQVQDTSLLLKWVTRDPYRRDMVYDQMAVMNLEKPLTEKEREKVRDQLCCLEGKMESVDHRSDWICTGIRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSC6</accession>
    <name>A0A194XSC6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_170687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077560.1">
        <property type="nucleotide sequence ID" value="XM_018205569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSC6"/>
    <dbReference type="GeneID" id="28815295"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_170687"/>
    <dbReference type="InParanoid" id="A0A194XSC6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="11096" checksum="202A47FD91835553" modified="2016-10-05" version="1">MLGLRIGGWRRLVSRPCEALVHHSFVMVVGLRKGDVIAHAWSFWGRCEVLIGGSCRFVVLFVGVFFFEFLWGEEGWGYVREVYLRGTIEGSGSEEMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSH9</accession>
    <name>A0A194XSH9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_573742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077508.1">
        <property type="nucleotide sequence ID" value="XM_018208699.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSH9"/>
    <dbReference type="GeneID" id="28818425"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_573742"/>
    <dbReference type="InParanoid" id="A0A194XSH9"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000577">
        <property type="entry name" value="WD domain G-beta repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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</entry>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    <sequence length="280" mass="31025" checksum="2A2F3C2A3E451BE6" modified="2016-10-05" version="1">MRFSFLTTLLPLATASSLPTTKADQQPQHIFSNPSSLHESTYRIPTSYESAVLARRILALTPLGTLSTVFPSSSSSNPHESENRPSGLGGLPIGLTDYISDCEGTGDPTILAINIATSFKNAAAGSNISVSLQWVPPYPPKSRIGSFTLPSLFSWFEKADEDKKGALPFSAANLPRFSLLGYLEKIDEGVIHNLELAKCFVSTHKDAKFWLPGNPIHTSEWVRLVVQDVYWIGGFGDRAYIGWIPVEEWRNVTTKEWESVRLPGEKKGWKEWSADAQWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTP8</accession>
    <name>A0A194XTP8_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_606355</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018210421.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XTP8"/>
    <dbReference type="GeneID" id="28820147"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606355"/>
    <dbReference type="InParanoid" id="A0A194XTP8"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30775" checksum="C9D4595B6F3010A4" modified="2016-10-05" version="1">MPFPDYIEKKPKIIFFTDFDGTISNQDSCDWLIEHEGYGYAKMQEGFQAVYDGKRTYGEVSCEQFESIKTPFDQCIEKILTHVELDEHFITFYEWCISASIPLVILSGGLTPIIRALLGRAIGHELRGVEIIANSVVVRNGFESLNDQGGAWRVQFHDENIYGHDKACAIQPYTKHREGLPKHEKSILLYAGDGVSDLSAAKETDLLFAKQGEDKYLVKYCKQQKIPFTEFKNWKEILEITQDLYHDSKSVRQVIEQNRGVLEGNDSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU32</accession>
    <name>A0A194XU32_MOLSC</name>
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        <recommendedName>
            <fullName evidence="8">Auxiliary Activity family 9 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_712823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078185.1">
        <property type="nucleotide sequence ID" value="XM_018218003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU32"/>
    <dbReference type="STRING" id="149040.A0A194XU32"/>
    <dbReference type="GeneID" id="28827729"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712823"/>
    <dbReference type="InParanoid" id="A0A194XU32"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268603" description="Auxiliary Activity family 9 catalytic domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="8">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="315" mass="32362" checksum="D3E89E3EADB6D68F" modified="2016-10-05" version="1">MSPMTKTSALLGFLASVAKVSAHGFVQGIDVDGTYYTGYLVTQYPYETDPPASIGWAETATDLGYVAPDAYASGDIICHKSATNAELSATVEAGKTVTMFWNTWPESHHGPVIDYMALCDGNCSTVDKTTLEFVKIAESGLISDTTSPGTWASDNLISNNNSWAITIPSTLTPGNYVLRHEIIALHSAGSTDGAQNYPQCINLEVTGSGTASPAGTLGESLYTETDPGILVNIYTTGLTYTIPGPTLWSGGSSGSTTSVAAVASSTQAAVVTSSASTSVPTTLATVVKSSSSVAVTSTSSAVETGAQGDDDSCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUI4</accession>
    <name>A0A194XUI4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_726925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078228.1">
        <property type="nucleotide sequence ID" value="XM_018219106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUI4"/>
    <dbReference type="GeneID" id="28828832"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726925"/>
    <dbReference type="InParanoid" id="A0A194XUI4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="798" mass="89576" checksum="E2BB697E137F97DE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUT4</accession>
    <name>A0A194XUT4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_183245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077822.1">
        <property type="nucleotide sequence ID" value="XM_018205635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUT4"/>
    <dbReference type="GeneID" id="28815361"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_183245"/>
    <dbReference type="InParanoid" id="A0A194XUT4"/>
    <dbReference type="OrthoDB" id="3553482at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="29731" checksum="4863369851182811" modified="2016-10-05" version="1">MRTSYSTMEKHTPYHGSIPATIFTCFLQLPLEMRREIWRQTIPTLPRFIPHSPHQQLARADPDRGIYFCINRESRSVYLEIYTSITSQLRISSIRGGLESTSPHANLEHDILYLRHDAYIGKLLQCKFKPEMMDGIRHVAIEEELFRECIPDFWGDILLAFDFVKYIHSFERLDTLTIVEIDHVVKMSLNGDLIAYYVELEKQRNLAGREMAFMGCEGKTEIMSWWTKMLEKSPDWKAPDLRFMRIGPTLKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV79</accession>
    <name>A0A194XV79_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_573974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077972.1">
        <property type="nucleotide sequence ID" value="XM_018208713.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XV79"/>
    <dbReference type="GeneID" id="28818439"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_573974"/>
    <dbReference type="InParanoid" id="A0A194XV79"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268639" evidence="9">
        <location>
            <begin position="33"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="58"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1114"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1412"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1114"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1163"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1341"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1412"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ23617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1627" mass="177453" checksum="5B853CEA5952529D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVU2</accession>
    <name>A0A194XVU2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_679577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078790.1">
        <property type="nucleotide sequence ID" value="XM_018213901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVU2"/>
    <dbReference type="GeneID" id="28823627"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679577"/>
    <dbReference type="InParanoid" id="A0A194XVU2"/>
    <dbReference type="OrthoDB" id="5289641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF1">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="180" mass="20282" checksum="C025040A9D9EC9DD" modified="2016-10-05" version="1">MNLNWIDPKPISDRDDSTRGVNTPPETIADDFLNDHDPLGTPKLSNSSVPWPGSTFIIRCAITGKVITLVDGKIIIAPPGGRGAIYWACIETKGWYGFREINSGRFLGHDKNGYLCCRAERQQGWENFCVRMTPEGGYVLLMTHWERLWHVGPKMDKGVEMLVKVGEKMADGMLWEFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWQ1</accession>
    <name>A0A194XWQ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_679591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078809.1">
        <property type="nucleotide sequence ID" value="XM_018213908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWQ1"/>
    <dbReference type="STRING" id="149040.A0A194XWQ1"/>
    <dbReference type="GeneID" id="28823634"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679591"/>
    <dbReference type="InParanoid" id="A0A194XWQ1"/>
    <dbReference type="OrthoDB" id="3550576at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19349" checksum="71BA80B0821A5E4F" modified="2016-10-05" version="1">MVLAHFICMGGCAIDTSKGRVLIAKRAFVILLKDDEHRDGIVAQLPSDEDIIDRSKTDTLTIILACAQSLWLVVQCIARKSVGDDISELELSTCGFVLCSLVAYGLWWDKPQDVEHRTVIQMPKTEAADDAVSRALSKALSINIQEYDSHRYIWMTFPWTTLLAPSILYIYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWS1</accession>
    <name>A0A194XWS1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_548228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079048.1">
        <property type="nucleotide sequence ID" value="XM_018208268.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWS1"/>
    <dbReference type="GeneID" id="28817994"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_548228"/>
    <dbReference type="InParanoid" id="A0A194XWS1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="237" mass="26017" checksum="F57352BA9FD1404D" modified="2016-10-05" version="1" fragment="single">PKRGLAYKSAKYVQNFQAPGSQVSWAYNWASDMDPTYPSYLEFVPMLWGNSTGHTSSWVSNVNKALARGSSHLLAFNEPDNCGGGACMTPQSAVDAYRTYMNPFAGKAYLGAPAVSNGPTGLPWLTQFLELCTGCHIDFVPIHWYDKATNEAYFKSYIGQAVAVAESLRLSITEFNGAGTEAQQEAFLTTVLPWLDSQTYILQYAWFWCDPTSKMGALVDSSANPTKLGNVYAYTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B189</accession>
    <name>A0A132B189_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_603796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947463">
        <property type="protein sequence ID" value="KUJ06138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B189"/>
    <dbReference type="STRING" id="149040.A0A132B189"/>
    <dbReference type="InParanoid" id="A0A132B189"/>
    <dbReference type="OrthoDB" id="2306559at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="83" mass="9282" checksum="BB885BE5C36C02FD" modified="2016-05-11" version="1" fragment="single">GSSFPADSAKPVPLAVVSLDNDEAFGYLKRVIVTPAVYPRLVEFLHFDIQSTGQKSHCVNTTFWPSQCYVLIRQSDSPCPYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B206</accession>
    <name>A0A132B206_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_703002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060783.1">
        <property type="nucleotide sequence ID" value="XM_018217285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B206"/>
    <dbReference type="GeneID" id="28827011"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703002"/>
    <dbReference type="InParanoid" id="A0A132B206"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="37728" checksum="A308E51EEC277A30" modified="2016-05-11" version="1">MQSPTTFLMASEMEADEEINHDWDFTIVCNSKHFVVTVLPGPLPEDPTTSLLTRYSKAFVEDDDEKIQEAQDEILDLVFDAGWQKFRAIAPPIPKGDSSPRISTKNLHSDLNPETFYFRLVVTEGHAEIVQTPPHPPQFNSFYLNLKDNTLDLPRYSSRDITVTSKLMGLGYIAKVLISGLDMCCKIGTTQSFKAVQREYDCLRQITISKSAASIPAPKLLGLVVDDNGVVLGILEEFIANKGRLSDVIKNEAGVSERRAKWVEQIRKAVALLHEIDVVWGDGKAENVLVGSESDDCFLVDFGGSYTDGWVDRTLMETRAGDDQAVEKIAKFLDDGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B263</accession>
    <name>A0A132B263_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_726526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060840.1">
        <property type="nucleotide sequence ID" value="XM_018219060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B263"/>
    <dbReference type="GeneID" id="28828786"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726526"/>
    <dbReference type="InParanoid" id="A0A132B263"/>
    <dbReference type="OrthoDB" id="10668687at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="570" mass="64191" checksum="6E2513EAC63A48DC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2I2</accession>
    <name>A0A132B2I2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_743738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
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                <person name="Labutti K."/>
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</entry>
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            <strain evidence="3 4">CBS 120377</strain>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36370" checksum="606B7D5E2514EFC0" modified="2016-05-11" version="1">MFSRLSQLVRHFSHPLPNYAHNSAAAFASSASRIMTSSTTADERNTRTIHTAACLIIGDEVLGGKTVDTNSAYMAKFCFKLGMALKRIEVIADDEEEIIEAVKRMSNNYDFVVTSGGIGPTHDDITYQSIAKAFGLKLKLHQEAYEKMKKLSKPHPNQPNFSWDVDSPAKRAKLRMIELPTDDSRDIKQQILFPVDDLWVPVACVNGNVHILPGVPRLFEKLLEGMKPLLLPRLTDPDGTGIHRIIISTPLPESAVAPYLTELAGRVEPKGVKVGSYPRWGKQNNTVTLVGRDQKLLESLVAEVEKNVEGRRVKVEGEDDVDVEAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3T6</accession>
    <name>A0A132B3T6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phthalate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_769634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060692.1">
        <property type="nucleotide sequence ID" value="XM_018221829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3T6"/>
    <dbReference type="GeneID" id="28831555"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769634"/>
    <dbReference type="InParanoid" id="A0A132B3T6"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="54816" checksum="013E75490A4EA7B6" modified="2016-05-11" version="1">MAEKIMPHEDHDDLEKPSLDEHVEHTGEALWTDPRITTFTVEEQKKIVWRIDIRLVLTLGFLYMISLMDRTNLGAANIAGMATELKMNDKNNAYTVVSVVFFLPYAFFQPVATVVIREIGPRRFLAAIVLFWGATMIGFGFVKNWQTMAGLRVILGALEAGFYPGCIYLLSTWYPRYQLQKRNAVFYLIGSMASAFAGILAYGLMQLNGRAGLTGWRWIFIIEGVLTCVLGIFSYIMIVDFPELSPTSWNFLNEKEADFVVARIEHDRADIQVEPFHLGTYLRNGLDWKIWGFSMLYVLTTTNSYAIAYFLPIILRDGMGFDIAKAQCLVAPPYVAAAIVMFVQAYYGDKWHLRGPIIVFNAAMGILGLGLLGYTHNQALRYFGVFLATTACNANCPALVTYQANNVRGQWKRALTSATLIGGGAIGGIIGTTVFRAKDAPGYKPGILTCLIANALIIVITAALTLKFWRANNRVRAGGKMIEGQAGFLYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4M3</accession>
    <name>A0A132B4M3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061713.1">
        <property type="nucleotide sequence ID" value="XM_018216414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4M3"/>
    <dbReference type="GeneID" id="28826140"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691816"/>
    <dbReference type="InParanoid" id="A0A132B4M3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8447" checksum="F9C2BE36CC984846" modified="2016-05-11" version="1">MQNQYPEQQYADLQYMAQAAQAAIPPSPSSIAVHFRLHPASEGQSQAMRFDGRCLCESCYSKQEKDEGVLHMLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9A2</accession>
    <name>A0A132B9A2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_676352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063331.1">
        <property type="nucleotide sequence ID" value="XM_018213577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9A2"/>
    <dbReference type="GeneID" id="28823303"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676352"/>
    <dbReference type="InParanoid" id="A0A132B9A2"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF5">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="525" mass="58758" checksum="BEDA4D572AB3F3F1" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9S2</accession>
    <name>A0A132B9S2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_320607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206712.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28816438"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_320607"/>
    <dbReference type="InParanoid" id="A0A132B9S2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288000" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12616" checksum="C40D13E499E3794D" modified="2016-05-11" version="1">MLPYLFFALCLSLPITNCRDPTGFRDQRSQRSWKVLPFCACRFVVSGRCKPPCLCSRFDNLLKLEHLKKLQPQPNFLGSSLCMGDMQVREVSSPIDTHTIQILPHQPAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBE2</accession>
    <name>A0A132BBE2_MOLSC</name>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">LY89DRAFT_316567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206674.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28816400"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_316567"/>
    <dbReference type="InParanoid" id="A0A132BBE2"/>
    <dbReference type="OrthoDB" id="5414787at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="859" mass="95138" checksum="5459854EE6B73E11" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBE4</accession>
    <name>A0A132BBE4_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_273750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063948.1">
        <property type="nucleotide sequence ID" value="XM_018206388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBE4"/>
    <dbReference type="STRING" id="149040.A0A132BBE4"/>
    <dbReference type="GeneID" id="28816114"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_273750"/>
    <dbReference type="InParanoid" id="A0A132BBE4"/>
    <dbReference type="OrthoDB" id="3562292at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="110" mass="12603" checksum="33E1527193F579C8" modified="2016-05-11" version="1">MYGKMFRVWRDLPMLADCMKTCFNGPSSMMRDRSSKYAQMWRELNSFGARCLGASVQSPYEQSMSALRSGLEEELSTIEEGLEPTTDHDTRKGEEVNKSTDSVYVDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBP0</accession>
    <name>A0A132BBP0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28830376"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740905"/>
    <dbReference type="InParanoid" id="A0A132BBP0"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="507" mass="57409" checksum="37EAD24BC0E28BEC" modified="2016-05-11" version="1">MKERIKIPDANNSIEVAGDSEGLEWRRPSNPSQPTSKPKFLPYLTKKPATAPKAYSRPLETTKSVPKFAQVASSSKEAILPPPRTATCDMAPILHLPLDIWHLITCQLHPSTISALTCTHPLLHNFLTPILYHSVDLSLSAPSTEFWPKTNISIMDHTWSRRSHIAKSQYLFIKQILAHPDLALHVRTLNWTIGLERMGLLPEEIQGEKPVWKDEEMYAVFEMLRDVVRLDVKTGTRSHGHLPLDMVGRGLFPNARYVKLSGIMRREFVDAVLSADMQTQSSDDARGKGKEKEMVGLENLSLDKVPLKTLNLDDLQEEGTFQNQATPYAFRRMSAKKRLLGTEVPQEVPRLGPCQPMQHILTPALYDRCRTLQRLSIRVYGMSERGSSDDELWMDWAVFIEEVKPQEVVFDCDRLPRSHGRGGGSALRFARLREARGRAAVANDRRFGETLLPVLRGGWEGLKLVEIRGVGESVVKELRVLEEKGVKVVFDVDNEESYKWLRTNEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC39</accession>
    <name>A0A132BC39_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_596855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209945.1"/>
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            <begin position="8"/>
            <end position="82"/>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="82" mass="9643" checksum="657F9D07A38BBD89" modified="2016-05-11" version="1">MPAPPTEDYYELLGLHQGCTEKQIKREYRRLSLKVHPDRWSPDSTKMASAHIAFSKVCPELSLWIMWVKAYHGSSTTHTRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCB3</accession>
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        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">LY89DRAFT_690344</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
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        <property type="entry name" value="AMP-binding_C_3"/>
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            <begin position="452"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="821" mass="91998" checksum="ED1616273230E6D4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDB2</accession>
    <name>A0A132BDB2_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_656190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212369.1"/>
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        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="62"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="340"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="519" mass="57216" checksum="9BD7F8BA752E1A76" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDC2</accession>
    <name>A0A132BDC2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_788083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064199.1">
        <property type="nucleotide sequence ID" value="XM_018223133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDC2"/>
    <dbReference type="STRING" id="149040.A0A132BDC2"/>
    <dbReference type="GeneID" id="28832859"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788083"/>
    <dbReference type="InParanoid" id="A0A132BDC2"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ09844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="36778" checksum="3828DDD3C7719553" modified="2016-05-11" version="1">MESTEAPQPAAPVALFKKRTTKGKSNLRKRAATPPPALDGDSDYSSSEDESGRKIKRRKKNTGAVTASSANNPSAASELTSTKYTADRSATIKSSNDATKQSNWYDENATDALSSKNLLGSTRATATTSEAPDGTYKGLANATSFIQKNPNAPTRVVGPIKAPTNIRTITVTDFAPDVCKDYKQTGFCGFGDNCKYLHARESYKAGWQLDKEWENVTKGKKNIGGTTIASANRNAEEEGSDDDDAALEGIPFACIICKDRYKEPIVTKCGHYFCERCALQRYRKDPSCPACGVGTGGVFNVAKGLKKLLDMKRERAAKRRQKAIEAGEEVSEDEEEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDI9</accession>
    <name>A0A132BDI9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_740167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064811.1">
        <property type="nucleotide sequence ID" value="XM_018220557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDI9"/>
    <dbReference type="STRING" id="149040.A0A132BDI9"/>
    <dbReference type="GeneID" id="28830283"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740167"/>
    <dbReference type="InParanoid" id="A0A132BDI9"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="552" mass="61576" checksum="C65145C32433FC7F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BED0</accession>
    <name>A0A132BED0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_272178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064559.1">
        <property type="nucleotide sequence ID" value="XM_018206375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BED0"/>
    <dbReference type="GeneID" id="28816101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_272178"/>
    <dbReference type="InParanoid" id="A0A132BED0"/>
    <dbReference type="OrthoDB" id="3554705at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="24359" checksum="8A7B535371EE59AB" modified="2016-05-11" version="1">MPTSQKESKSSLNRGSVKSAVDAPSGTQRITSSAYSQSGGMKTHTHLHAVSIKVQKAGTTTPSSMSHSQNSARLTKAASSSRIPVSETINVVASEPPVRSISFRPAETSISGREISDKQADEMCRELCLRVWKTDLGKMWDSARAADKKGNVDDQLYGQSLDFFYCFLPMVIKAPATDPVTVSKQGLENYNVLFNRFGDGGTWGQGQSGKNFPHMWFSGPGSEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRV1</accession>
    <name>A0A194WRV1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065068.1">
        <property type="nucleotide sequence ID" value="XM_018215894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRV1"/>
    <dbReference type="GeneID" id="28825620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689357"/>
    <dbReference type="InParanoid" id="A0A194WRV1"/>
    <dbReference type="OrthoDB" id="3562136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="16432" checksum="747F811C13DE8042" modified="2016-10-05" version="1">MAACNHEKTYSKTPPSLRFLSHNFPYIIPNQALNRFVSRCKLCDLIAAQDRATIAENPPPGINMVEGLERDIDLIEEMIAAGIATKQEEEDLGGLRKELENAIMFTNLRIDEAWLPYWEIWGPGDGPELLLDSLFDDGEDVIDWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSC4</accession>
    <name>A0A194WSC4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_251644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065221.1">
        <property type="nucleotide sequence ID" value="XM_018206200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSC4"/>
    <dbReference type="GeneID" id="28815926"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_251644"/>
    <dbReference type="InParanoid" id="A0A194WSC4"/>
    <dbReference type="OrthoDB" id="3561247at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="25328" checksum="18339A7B29D574CA" modified="2016-10-05" version="1">MSYQPSVSFPALPTRRTLFPGRPETSLKRGRAPTRSDENQPTLPPHARPKKKCPPLKPSGAFMFKGTNPLYVRTTFEPDHTKMTISCGYPGCHDFPPKLVDRGLQSTNNYRSHYKKYHPRVPVTAVEVLDVTQRTKKSDQLPSEKPVEQQSHDERYRVLLLAFILKNNLSFSLVDQPETRDLISFLSPTTKQVSRKVMMIDMKNLYAKGKDKQQAVFIEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSQ5</accession>
    <name>A0A194WSQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_253306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065331.1">
        <property type="nucleotide sequence ID" value="XM_018206222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSQ5"/>
    <dbReference type="GeneID" id="28815948"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_253306"/>
    <dbReference type="InParanoid" id="A0A194WSQ5"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="309" mass="34850" checksum="E96FB8A3F26B8BCA" modified="2016-10-05" version="1">MSSKPSEKPGFAAPNFSWADYIKHRPIYPSSYYDRIYRYHSEHSNTWDVAHDVGTGPGIIAQELANKFTHVVVSDPNDTYVDIACDRLTNEFGFPKSKFTFLQESAEKSSVEDGTVDLLIIAQAMHWADVEKAMKSFARQVKSGGTLAISFYGRAQLSNNPKAQAALDKVYDVWTDKLIEGGGFAARAMRATDSAFDIVPFSTEDWEPGVKRTLINTGGKKEPMAMSVKNKASYESKVGKDDVFEAEKDDNWTEVRDLKWLKEFFVTLLYNIPEEQVKRFWDEVEEAIGGLDIPVDIFYPAVQLLATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT50</accession>
    <name>A0A194WT50_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_689059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065488.1">
        <property type="nucleotide sequence ID" value="XM_018215836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT50"/>
    <dbReference type="FunCoup" id="A0A194WT50">
        <property type="interactions" value="1224"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WT50"/>
    <dbReference type="GeneID" id="28825562"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689059"/>
    <dbReference type="InParanoid" id="A0A194WT50"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="29667" checksum="CD1D1F1F48459196" modified="2016-10-05" version="1">MPQNEYMERWKKLHGRRLDHEERARKKAAREGHKASEDAQKLTGLRAKLYQKKRHHEKIQMKKQIKAHEERNVKSSAPAEPSSTPLPQYLLDRSNPTNAKALSSAIKNKRNEKAAKFSVPLPKVRGIAEEEMFKVVKTGKKTAKKGWKRMITKPTFVGPDFTRRPVKYERFIRPMGLRYKKANVTHPELGVTVQLPIISVKKNPQNPMYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWVSHVCFMFKIQPLPKFNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTA2</accession>
    <name>A0A194WTA2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_556551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065540.1">
        <property type="nucleotide sequence ID" value="XM_018208377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTA2"/>
    <dbReference type="GeneID" id="28818103"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_556551"/>
    <dbReference type="InParanoid" id="A0A194WTA2"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="238" mass="27302" checksum="A11399EFC0B2FBC9" modified="2016-10-05" version="1" fragment="single">ILMTMVAFSAIALYNVLELNVIIFATFRCRKGLYFWSFIVATWGIVPHTVGFIFKFFAVTSVWWAPLVLVSVGWFAMVSGQSVVLYSRLHLVVRNYERIRWVLYMIIFNAVVLGIPDMILAFFTNRPNAQASVVNAFTIFDKVQVSIFFVQECIISGLYIYETVRLLRPAEDIGRNPLRKLLVHLILVNVLVLIFDATLLGTEYSGNWEIQTTYKPAIYSIKLKIEFSVLNRLVSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTE4</accession>
    <name>A0A194WTE4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_239848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065580.1">
        <property type="nucleotide sequence ID" value="XM_018206105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTE4"/>
    <dbReference type="GeneID" id="28815831"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_239848"/>
    <dbReference type="InParanoid" id="A0A194WTE4"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="427" mass="47055" checksum="6ED8AC60F81EED24" modified="2016-10-05" version="1">MTPSPISTGPSTQPLNSPASGAMSVASIVSPTSYGFAHPFYEGNNSLNGTNGDSRRESVDSRLGANFGDMRLANSPYASANPSTTSLQSTLAQQRNPGSAHPDRNSGPFRLSSGYQPNYQRVPDGPSMTSRTAPLITGPALGAIARAPEPTKGQAWAFPEEEVQRLPSAARPSDDTNRHGTSFYDDSRRNSYADSIASSQYTTESRLPPGQRRLEDGVPSDYHRASSEYQVSTHHHSLQHRQISELQNDDGSPTNSQPYSRTPELRVSHKLAERKRRLEMKDLFDTLRTLQSVERGAKASKWEILSKAISEHERQTKIIDDQKKQIQRLEAHLGRVEHDLDIARREANSARLENAQLRSDVSGLQGGAPGYHGPAPPVQHSHGYAMQPSEPQQQLPPLRNIPGPEVMNGVQYQHEQRSNGYRPGDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTQ1</accession>
    <name>A0A194WTQ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065419.1">
        <property type="nucleotide sequence ID" value="XM_018220449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTQ1"/>
    <dbReference type="GeneID" id="28830175"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739278"/>
    <dbReference type="InParanoid" id="A0A194WTQ1"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="39979" checksum="A35BC93E7E9205D4" modified="2016-10-05" version="1">MDVDEESSSPVLDKASILASYAPSEAPFSLPDTLPSSPTTISSPIPLPETTESIEYSYTEPLLPSTRTVKVYHKDIAPLLSSAGVRGLITTVVHGTYSSRPATLILFSFSFRSGDHGFRFKNANIKIQFSNRPSSKPEETSPAIATFAPRKIYGLPTKEGRKNTIGGEISLQVPAGPLTVGPTLNGSRESEWEQTHRYKTVGNFWSSKYGTDWDIVYWDMKENKRTKEGIPDRLNVGVVVEREEVGAFTASVDIEVDTPVLSGAFSSPWEKRRPAAFVPGVEMGKWKRTRRFEELSERDWRELVPFEEEWESVFVGERMNRSLEVPGAWPGGPHAAQNDGNDGDVDFVRVKVDIGEQGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTT1</accession>
    <name>A0A194WTT1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_654661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065372.1">
        <property type="nucleotide sequence ID" value="XM_018212311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTT1"/>
    <dbReference type="STRING" id="149040.A0A194WTT1"/>
    <dbReference type="GeneID" id="28822037"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654661"/>
    <dbReference type="InParanoid" id="A0A194WTT1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="270" mass="30794" checksum="89D9F50418351FF9" modified="2016-10-05" version="1">MGDVQTYVTYWKQPEDGSGPDSGDWKQLIVGHKHQGDRRDIVAHDVRGNESTYSLDKHGFEIHKLPTKERDHLNQEEVQKEYYQEIIDLIKKQTGGKDVTCFGNIVRQYKRDALTPEEFIPGQVQGPSPRVHVDVSPIDPERLVGNMMPGKLDAMTKGSRWQFFSIWRPTKSVSRDPLAYADSGSVPNSDYCDIVGPKYNGTILKCGDKREHRWHYCSNMTPDEVVIVKHLDSKRDIPAWRCPHTSIPLPGTEDLPARESIEVRALVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU61</accession>
    <name>A0A194WU61_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_786793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065502.1">
        <property type="nucleotide sequence ID" value="XM_018223020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU61"/>
    <dbReference type="GeneID" id="28832746"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786793"/>
    <dbReference type="InParanoid" id="A0A194WU61"/>
    <dbReference type="OrthoDB" id="10559289at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="168" mass="19328" checksum="D716CE19A47B7593" modified="2016-10-05" version="1">MQLRTGGLGGQLMGTSCSMYGKGKGKGGAKVQNLAFEVDYASNLKPLAVIKREDYFWNRLSCRYPDKMRFSKLPAVKSISFLMLDWYEVVTFCLDDVGLLEPEQWCFSLDADSDIFKAAMGSKWRNVTWKVTIAKDGNRSLCELLMNWNPDGWTWRYWQRLQHEAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUF2</accession>
    <name>A0A194WUF2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_739019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065946.1">
        <property type="nucleotide sequence ID" value="XM_018220430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUF2"/>
    <dbReference type="GeneID" id="28830156"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739019"/>
    <dbReference type="InParanoid" id="A0A194WUF2"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="561" mass="64322" checksum="FF6A2A76CA759BEE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUH6</accession>
    <name>A0A194WUH6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_758307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065965.1">
        <property type="nucleotide sequence ID" value="XM_018221434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUH6"/>
    <dbReference type="GeneID" id="28831160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758307"/>
    <dbReference type="InParanoid" id="A0A194WUH6"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="528" mass="57270" checksum="0ACD70F9BD728C15" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUI7</accession>
    <name>A0A194WUI7_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">CNVH-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_786946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_786946"/>
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    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
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    </dbReference>
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        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="305"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="998" mass="113021" checksum="42799FFAE36CAB04" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUR2</accession>
    <name>A0A194WUR2_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_689222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065707.1">
        <property type="nucleotide sequence ID" value="XM_018215867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUR2"/>
    <dbReference type="GeneID" id="28825593"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689222"/>
    <dbReference type="InParanoid" id="A0A194WUR2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16564" checksum="221AD08389638F1F" modified="2016-10-05" version="1">MSYSAGRYKWEVLRYLTKKELSRLTLTLICRPKAMSPSSFQLEQTSPRTVFRNSIVIEISPMKPSDDIFITAPLTSQIDCRSLSQPCYSNSLSHLAATLGDEYHTSAGAAHRALALVILQRAKIMDSKIPRGVGAMLWAKGGSMEGRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVJ1</accession>
    <name>A0A194WVJ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066343.1">
        <property type="nucleotide sequence ID" value="XM_018213388.1"/>
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    <dbReference type="GeneID" id="28823114"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673783"/>
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    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14101" checksum="502A9AA185848B0D" modified="2016-10-05" version="1">MAQRKSNTALYLGVAAAGGVGYYLYTAGGSPKVAEKQFEADVSKASAKVQEQIPGRTNQAQKEGEKWASVAGAKVDSAVEKGRAELAKAEGKLDQYRKEASADTMKKIDQADKKIEEKAAQAKSGISSWFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXF8</accession>
    <name>A0A194WXF8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_722008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066724.1">
        <property type="nucleotide sequence ID" value="XM_018218693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXF8"/>
    <dbReference type="GeneID" id="28828419"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722008"/>
    <dbReference type="InParanoid" id="A0A194WXF8"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="32342" checksum="4E83F9E0B467D1FA" modified="2016-10-05" version="1">MSTTTPLVWFITGCSSGIGLHLALHALRHGHHVIATSRSPSPSSPPPSELITSLGGHHLTLDVCSPLPILAEKVNEAMSIYGRIDVLVNNAGYALLGAFECISDEEARAQMETNFFGPLSLCRLLVPHFRHRRTGTILQISSAAGLEARASRSLYSASKFALEGFSEALSNEMQPFNVRVLLIEPGAFNSEFADKCVTPAKGWEEVRDEYRGSEMERVMGLVEGMRGGNMRNDVGKGVQAIWDTVMGTGVAEGMEAFLRVPLGRDAAERWEVVGELRRRTLEGTRRVWESCERDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXR9</accession>
    <name>A0A194WXR9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_709623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066747.1">
        <property type="nucleotide sequence ID" value="XM_018217772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXR9"/>
    <dbReference type="FunCoup" id="A0A194WXR9">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="GeneID" id="28827498"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709623"/>
    <dbReference type="InParanoid" id="A0A194WXR9"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="312"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="3">
        <location>
            <begin position="570"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="691" mass="75633" checksum="BD7F8331D17A2DE1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXV2</accession>
    <name>A0A194WXV2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_209263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066869.1">
        <property type="nucleotide sequence ID" value="XM_018205851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXV2"/>
    <dbReference type="STRING" id="149040.A0A194WXV2"/>
    <dbReference type="GeneID" id="28815577"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209263"/>
    <dbReference type="InParanoid" id="A0A194WXV2"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26128" checksum="698C54C0AE699040" modified="2016-10-05" version="1">MPKILTSENLFGSSAPDISAGKHGVRELLRIAKFPMKFRDDHLQSLIAGLKQHKKSHLTPQTLDIATTFAPIVAHISIAGLMTAYYHHGGADRVWYIVRPSHKRLFETHFKELFADRIGRYTCSQFVSHVSLWLDLHVSQLGPLGIRCAEVHQGPGQVLFVLPDSYVWGYSRGYNIVERRLLAPPGWTSTPEHYKPCFDGEILCRGDPCRNKYVKAGNAPEPEVKGQVDDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYA5</accession>
    <name>A0A194WYA5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_757131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066942.1">
        <property type="nucleotide sequence ID" value="XM_018221405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYA5"/>
    <dbReference type="GeneID" id="28831131"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_757131"/>
    <dbReference type="InParanoid" id="A0A194WYA5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="32080" checksum="6BA77F92D927FEDE" modified="2016-10-05" version="1">MSYNLEKDVVDSNDSRNSVSDLEDCPLTGDENHLPLKEQRRKFNFRWPADRSPFWKFWSIAMTIITLILVAVGSHKTSVHDVSLCSASDMKTPTEETYNSGDAVVESWKKENLVETHYYRDLRYMTLNHDSDWLWKEHLDMLSGNIILPAAEDGSTNATLKSISMFHQMHCLAKMRMTLQRAREGEDIGEDWKDDAHWPHCFDYLRSSIMCYADGTLESVSRQPGPVDDGTFVEVIDGGEELRYCRDTKPIYELVRHYGPSSRYGYASKETDFEVAPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYQ7</accession>
    <name>A0A194WYQ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_709519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067451.1">
        <property type="nucleotide sequence ID" value="XM_018217767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYQ7"/>
    <dbReference type="STRING" id="149040.A0A194WYQ7"/>
    <dbReference type="GeneID" id="28827493"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709519"/>
    <dbReference type="InParanoid" id="A0A194WYQ7"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="266"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="423" mass="45252" checksum="9FB0B7B6E42E48C8" modified="2016-10-05" version="1">MIDFTLSESQNAIRAKAAAFSSSVLATAAAKYEKHPTQIERFRALRPFYRQAVEAGLVRGLIPKAFGGDAGTVVEAALLVEEMCKYDRSLSLSIFSTGLGLSSLLIAGTPEQKEELLKPFLSGEGEPLASLLHTEPEGIANWLEKGGKGLQTVARKDGDDWVINGEKIWATNCCGWDDRGADVQCVVCRYSQDGQSQAAEANPAEATMILLVTRDLIASNDLGAYQILKHIESTGHTSTAGPHVKFTNFRVPGHRLLAAPGQAAAVITRAFTSSGALVGAMSTGIMAATFEAALDFAKKDSRGGAQALITRPTVSDLLMDIKMRTDAARFLTWKAASALDNGKGGELALEAKLFCSDLAVKVVVDAMTIVGVTSYNKDSPFPKLLNDAMCLPLTGGGNIGVRRRQLEQLFMADGYRPWASTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYZ4</accession>
    <name>A0A194WYZ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_673020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067269.1">
        <property type="nucleotide sequence ID" value="XM_018213325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYZ4"/>
    <dbReference type="GeneID" id="28823051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673020"/>
    <dbReference type="InParanoid" id="A0A194WYZ4"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51514" checksum="05E5C51250760325" modified="2016-10-05" version="1">MDVEAIDKGSAGKAGRKPSSSGPRSIAALSAEQIARKRATDRACQRVFRQKRRERVEQLEARYKELLRNAPDKAELQAAKQRGIELEEELKRLRAVLDKRKAELGIELTEPSQSSLTVVPNPTPRPSFRDSQAVKSSVSTPKPYLPAVSKSEPDQSTSIGSALIQDSSSGSIWPTTVATDDRPHLSLRPSAQVQRRVSINDVDTVELRSTPLITSPDRKQRPATYFMRQPCLHEWEIPPALRSPSTPIDKILYGMVQHQRALSKKGIHSIELAGPRNPSMTALVAPEQSATVHTVARVISDLLNKITYRTFVDKLGAFLVIYPIYQWLIMQSYETYHNLPSWLLPLLSQRTTPHPIWIIAVGTPTLRDVIIANQEKYDTEEFQFLFVASINVNWPHGLEAALSRKHGGIAASKAFWDHARDLKNWTLDEPFQSRYPELKGFVPFTKYPGKDVRVGNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZG1</accession>
    <name>A0A194WZG1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067449.1">
        <property type="nucleotide sequence ID" value="XM_018213344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZG1"/>
    <dbReference type="GeneID" id="28823070"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673192"/>
    <dbReference type="InParanoid" id="A0A194WZG1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="47862" checksum="2FF129D1DC53A8B3" modified="2016-10-05" version="1">MQFPSHDVDAARRWLLAPASKQLLSNLTPSSSRLAYDWTPLESLIMGVVGLTRELFYASFADACLTILGGKQNVSIELPQDARRRICFSVGTEAFSVILRITKVAWKDVMRDWLTAALIAFAPQAINIWRSRDWNCARKVSQNRQEPQTLPGEYKTASMHCASSSCLVDQGRSSSNEQKSHFSVAVENRREKHQEPEYVTGNHDETEWDYKEAAMKQKEKRAVLDISYVKALKLDDMAQRAVLQNPANRQVVMDRVRCSVEARRQIIDFHASIHRSSTPAASIDIDNILLSFNGLLNHHSRSLAGTKIHTVKKIIEVGILSKLDTDFSYQTKKDGISTLVAMMTSILAKGGDGDYASVLEDEQLPNVLGQAILEIAQLMSTFDREQLAKEKHLLQMISSIKDFKYQGQRPWELLDEFVSLFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZJ7</accession>
    <name>A0A194WZJ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067728.1">
        <property type="nucleotide sequence ID" value="XM_018215515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZJ7"/>
    <dbReference type="GeneID" id="28825241"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687514"/>
    <dbReference type="InParanoid" id="A0A194WZJ7"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="351" mass="40968" checksum="21DC69DE7A9CBB86" modified="2016-10-05" version="1">MEMSTSLDFDVRAVYLNDDTKYAILNTIWSSTHTARDFSNDPSIGDSYLRYYGDQCRNALHSRGFNSIIKTHADVADIVNRLKHPIMTRERLQEYLRTKVQHPSTIDDDEPLCYIIDLAVRLWLIDVGKIQHGFVPGQKPLLWKAGSLKDLVEDRFAGLVSGPSRVVTVKLDRLFTARNLERIAGLQIIWTDNISDHLRLMVDDTRIAIYHHASFLEHHENNCIFPAGFIEETLRTISLLFPQYDKESRKWFKAQQLKFSLDKKTSTSGHLTTEERQIENFVFWYDRLSILKKAFDEAEPSTLAQWWFDRRRRVQWYTFWLAAIVLTLTVLFGMVQCVEGGFQVYKAYYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZK0</accession>
    <name>A0A194WZK0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_785094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067731.1">
        <property type="nucleotide sequence ID" value="XM_018222853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZK0"/>
    <dbReference type="STRING" id="149040.A0A194WZK0"/>
    <dbReference type="GeneID" id="28832579"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785094"/>
    <dbReference type="InParanoid" id="A0A194WZK0"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="574" mass="65384" checksum="1D838DB0BEC82C52" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0F4</accession>
    <name>A0A194X0F4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_687078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068036.1">
        <property type="nucleotide sequence ID" value="XM_018215420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0F4"/>
    <dbReference type="GeneID" id="28825146"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687078"/>
    <dbReference type="InParanoid" id="A0A194X0F4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="73" mass="8224" checksum="BAE9B0F240CCDD20" modified="2016-10-05" version="1">MLKPPKKTLFSALLFPEVRNAQRGLSFSVDTAPGRKVLSHILGLFAFEKLVRVSSRWKTSQTSWCDTDKPCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0N8</accession>
    <name>A0A194X0N8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068116.1">
        <property type="nucleotide sequence ID" value="XM_018215434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0N8"/>
    <dbReference type="STRING" id="149040.A0A194X0N8"/>
    <dbReference type="GeneID" id="28825160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687134"/>
    <dbReference type="InParanoid" id="A0A194X0N8"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="1" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="1" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="260" mass="28245" checksum="CDCC0937E5B0515B" modified="2016-10-05" version="1">MPDNRDPIIQRGVYGTSIVGTSLMVGLRTADIFLQYGILAKGLADPLLNYLNVSQTPNFAPAIAFGLPLQPLLILAMAAGSSIKQAYWVTCISREEMSPSSAIFVSIFNTVFNSANSILALTAAASAFTPSILTEQDKNGASILLIASTVAYFVGLAVEAISETQRKAFKDDSKNAGKLYTGGLFGLARHINYAGYTIWRAGYSFASGGWIWGSIVAAFFTYDFTNRAIPVLDEYCSERYGASWTEYKKKVPYKFLPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Y9</accession>
    <name>A0A194X0Y9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_672134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068213.1">
        <property type="nucleotide sequence ID" value="XM_018213261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Y9"/>
    <dbReference type="GeneID" id="28822987"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_672134"/>
    <dbReference type="InParanoid" id="A0A194X0Y9"/>
    <dbReference type="OrthoDB" id="3904217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="163" mass="17910" checksum="6848C43E8A517E48" modified="2016-10-05" version="1">MPSPTDLIGTWTLLSFAFYTSSSCTSLHSHPLGPHALGRLTFSSDGYMNAFLSNPDIATPLSVPWMAAPETDIGRVARVQAGYCGRYTVYEEGGESRFATEVEMAFDPGLVGRRMVRRWGVEDVEGRRCLVLRPVEGFVLSDGGQAFAELRWVKVELDSDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X137</accession>
    <name>A0A194X137_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_145362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068039.1">
        <property type="nucleotide sequence ID" value="XM_018205347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X137"/>
    <dbReference type="GeneID" id="28815073"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_145362"/>
    <dbReference type="InParanoid" id="A0A194X137"/>
    <dbReference type="OrthoDB" id="3453920at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267775" evidence="1">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="170" mass="18758" checksum="0F1FAA744F31B29E" modified="2016-10-05" version="1">MYAFNKVMKLLISIAIAMVLLTLNSVSALPTSEVAEIETRSALHPCSVFIQRWCQDCEERFDVAYYNVTWTTPWNWPIAAFWNQESDEVNVPTVGSELVAVQVGSNILHIIDTADPAPGDNNDPGKLSFVWGTDTWDSFSPGSPCDVGPVGTNAQYGGSTNYECEWLCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1H1</accession>
    <name>A0A194X1H1_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_152270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068400.1">
        <property type="nucleotide sequence ID" value="XM_018205411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1H1"/>
    <dbReference type="GeneID" id="28815137"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_152270"/>
    <dbReference type="InParanoid" id="A0A194X1H1"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="148" mass="16975" checksum="FE403593F9C7483C" modified="2016-10-05" version="1">MPAALELDNGKHITYELALKKDVNIINEATYPRARRRLFQKLWDQRATIQALVRHHLRLRDQDACIVKAESQWIRGSFNVCIPVEVRSASFNKNLIFRCPMPHKLAEAKHPGTIDEKLSCEVGAYVWMLSMRIVRSLGGAIQAVRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1K4</accession>
    <name>A0A194X1K4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_651143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068430.1">
        <property type="nucleotide sequence ID" value="XM_018212137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1K4"/>
    <dbReference type="GeneID" id="28821863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651143"/>
    <dbReference type="InParanoid" id="A0A194X1K4"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23544" checksum="06726E7FB49585C1" modified="2016-10-05" version="1">MFSRNKNTSTHNGAGTVSGPARTTRSHSLIQHLLRALQFLSAFTSLILFSVRLAKILRLVHKASHSNGAVEGILAAAVLYTLIATALTCGLRAGGGNMLRILLIIFDLLFVGAFIAVAVLTSPKRHGSSGPCTSNANANHLLTHYTSNDVNCRLPWGTFILAILSTLLHAATAAFHGVKDHRRTHRNDHVTKHEAAQNDGRDGYVDGNAPGYNGARATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3N4</accession>
    <name>A0A194X3N4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_122139</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069131.1">
        <property type="nucleotide sequence ID" value="XM_018205153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3N4"/>
    <dbReference type="GeneID" id="28814879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_122139"/>
    <dbReference type="InParanoid" id="A0A194X3N4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="78" mass="8549" checksum="4B7831CD716D551D" modified="2016-10-05" version="1">MLASFLRHQTLSFDKRLRLLSSTSSSTSSFPAGSTATSSPLRHRLVRTKPSDQPLKQLNPSALGRLGLCFCFPEKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X478</accession>
    <name>A0A194X478_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_117893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068982.1">
        <property type="nucleotide sequence ID" value="XM_018205121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X478"/>
    <dbReference type="GeneID" id="28814847"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_117893"/>
    <dbReference type="InParanoid" id="A0A194X478"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="26609" checksum="AB964B6ED4198218" modified="2016-10-05" version="1">MDICPTTSINHHTPMSNTSPEFTLFRFLPTELRLKIYDLILALPPSTTEPRRILKISYSPSLSRYISATPPPTLLHLSHEARTYTQNHYTPLLLGSNAKSPTFHASIPISFLQDTLYLSSLSPLLFTHLHDILFHLSTSPSRHQIQSLAIDLRCWSELIENGFGGLLARMRGLKEVLLVVEFGRVGCFRGVLGFLEVPSWRGDLYWLAETAEMRLKEERLRVRKGGKNPGDDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4C5</accession>
    <name>A0A194X4C5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_708555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069381.1">
        <property type="nucleotide sequence ID" value="XM_018217688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4C5"/>
    <dbReference type="STRING" id="149040.A0A194X4C5"/>
    <dbReference type="GeneID" id="28827414"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708555"/>
    <dbReference type="InParanoid" id="A0A194X4C5"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="75"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="196"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="41165" checksum="347A30CFA71E7745" modified="2016-10-05" version="1">MSNLHPFDIAKCARPNILALKPYTTMRDDYSSNADVTLLDANENAFGPSIASELSTSTCGSGVTIQSALDPKELQLHRYPDAQQTPLKQLFCDLRNTSQSPDAAAKPLKPENVCLGVGSDESIDGIIRAFCTPGKDKILIVCVNLDTENGFSLRSSVTNETLSNDPLIKVVFLCSPQNPTGNLLLRPDIVQVILAAEVNAWPNLIVTSTLSKAFGFAAIRLGVTFSQPQISQLLNNLKGPYNMSAPTIALATLALQPEGIALMKENRVRMFEQRARLLQELPKIPGFGKFLGGFNTNFILVQFLSKPADQGGIPDNVIAQALLHALVTKSRILVRYRGKEAGCVGSLRITKGTGEEVDTILLQIRTALEEAYAREFPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4M4</accession>
    <name>A0A194X4M4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_685948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069488.1">
        <property type="nucleotide sequence ID" value="XM_018215179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4M4"/>
    <dbReference type="GeneID" id="28824905"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685948"/>
    <dbReference type="InParanoid" id="A0A194X4M4"/>
    <dbReference type="OrthoDB" id="3564628at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16575" checksum="C32953B7B021254B" modified="2016-10-05" version="1">MDPLTALGLAGNIVQFIDFAWKLFEGTKAIYKSASGSSHDNAVLQSIANDLRHLSNGIIISNQHSEELRRLATESKRISLELLDALEKLKLQGRNTKWKSFVLALREAWSRGKINEMSDRLSALQSQMNLHIQIMVRALLNSQENVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4S1</accession>
    <name>A0A194X4S1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_686622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069419.1">
        <property type="nucleotide sequence ID" value="XM_018215328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4S1"/>
    <dbReference type="GeneID" id="28825054"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686622"/>
    <dbReference type="InParanoid" id="A0A194X4S1"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="51"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="352" mass="39318" checksum="4B6B6A00486A7498" modified="2016-10-05" version="1">MDVNTMMEDNLTARVPTIGPDDVLRYIQTRSASLKYLFVFFLLLTNACAGLRLYVRCRLVRIFGADDIFLLATMTCFTMYTFSGLFSIRYGIGSNPHEVDNNKTLSAALEWWFLAELFSVLAAALLRISASLHMRKLAETDAQQWLILFIGTGTTVYSTCFFLLQLFQCTPIHFFWTGWLGAEGRCMDQQSLAKMEYVFTVFGVLTDLALAVVPIWLLWTTDLSRKSRSRIRALVLVGLCAGAAALIRLPATQLLPTTDDFFFDCVPVAVSSILEIGMGMIALSAAAYRPILPGFFDDSNKILTAKLPPPIPEEFRTPTKGYGDLASMTGVQMSPRSASFRKVSEARTRYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4Y8</accession>
    <name>A0A194X4Y8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_107188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069598.1">
        <property type="nucleotide sequence ID" value="XM_018205050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4Y8"/>
    <dbReference type="GeneID" id="28814776"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_107188"/>
    <dbReference type="InParanoid" id="A0A194X4Y8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="14648" checksum="FD33487AB0F18C73" modified="2016-10-05" version="1">MGPGILSLSRFASREVENIGPGMDSPSRLASSEVVNMGPGMLSPSRFASREVVNIGPGMLSPSRLASRDVVNIGPGMESPSRLESRDVENIGPGMESPSRFAMSFEVENIGPGMESPSRFRTGAATPVPARRAADKMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5R4</accession>
    <name>A0A194X5R4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069871.1">
        <property type="nucleotide sequence ID" value="XM_018215242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5R4"/>
    <dbReference type="STRING" id="149040.A0A194X5R4"/>
    <dbReference type="GeneID" id="28824968"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686250"/>
    <dbReference type="InParanoid" id="A0A194X5R4"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="561" mass="62220" checksum="B37E62CC97AA1350" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5V1</accession>
    <name>A0A194X5V1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_735565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069809.1">
        <property type="nucleotide sequence ID" value="XM_018220030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5V1"/>
    <dbReference type="GeneID" id="28829756"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735565"/>
    <dbReference type="InParanoid" id="A0A194X5V1"/>
    <dbReference type="OrthoDB" id="3543282at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267880" evidence="1">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="23376" checksum="038BD66270B878B7" modified="2016-10-05" version="1">MRLSHLLTLVLQCQLIYVSALITLESIRDLTRLTDDMRARIEGSGKVSIVPGQRVLGGGEDGDEIEDVVAAALKVLCSELLRELEKPLIEPLNAEVLVDVGEQDLRCRVIRRGYHGFLEATVKFLHEVQERELRWQWDHESMVFEGVGWLQGLWASRKTNIQDRSFIEQQMMLYSETGCFGKSQEVLRSGVEVVEYLNDLLDSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6E6</accession>
    <name>A0A194X6E6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_719470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070111.1">
        <property type="nucleotide sequence ID" value="XM_018218497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6E6"/>
    <dbReference type="STRING" id="149040.A0A194X6E6"/>
    <dbReference type="GeneID" id="28828223"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719470"/>
    <dbReference type="InParanoid" id="A0A194X6E6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="293" mass="33359" checksum="ED5C1CB7D4193FA2" modified="2016-10-05" version="1">MSTLVSSGLKDGLAFYYFDHNDDPEKYTNFGALVYYHYAESADILLADLKAQQSAHPWYSLCSIVLFCYLFRKVQQKLRPPVAYPTRAAPPPPQGKDSGIDMPRQSENLPALAYIPPQQDTAVTLATRLSQSRFGISSIKDQSQEVAGKVQQIEYLLRPRQEEYREILGHYSAGVSNEFHEFLPSKRTTSKLILIKLCSFVATVVRWKCRAEKAMVLCARIRRHWLHADVLAAFASPVIFGERGLGSDRVISQVRFERDYDSHDRVFKAASWPYITGEDDKNEEPGYQQTRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7H2</accession>
    <name>A0A194X7H2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Yippee-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_587189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070112.1">
        <property type="nucleotide sequence ID" value="XM_018209413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7H2"/>
    <dbReference type="STRING" id="149040.A0A194X7H2"/>
    <dbReference type="GeneID" id="28819139"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587189"/>
    <dbReference type="InParanoid" id="A0A194X7H2"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="55"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28271" checksum="E129DA77ED40BA64" modified="2016-10-05" version="1">MAQEPRPPFATYLIPSFHFFFRRRSHDHESQRQRQQSTSSTVSDNVPSLSYSPPNTLRCITCATDIALASQIVSKGFTGRHGRAYLVSAPISLSQASYPPPIPNSTNKDHEWKPDELINTKTGRRVNRELLTGMHVVADVSCNICATTLGWKYVDAKEPSQKYKVGKFILEMKRVVLRVGWEDVTDDEIDEDDGVREYLEEEGEGEEGGPVVFDSEDEDECDDLFAGVWDAEVVRKRRGRRVGGWKRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8H5</accession>
    <name>A0A194X8H5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_782717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070820.1">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="12816" checksum="CC7E52E8607AF451" modified="2016-10-05" version="1">MASATPDKPSVKRTILQSLPIPEFPGWESRLVLFEYPPGVAAPVHNHPVAGTGFVLEGNVASQWEGKEVELYTKGDTFVDWGTTMHLRSENTSQTEWLKFIISYVIKVGQPNVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8M2</accession>
    <name>A0A194X8M2_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_734624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="CDD" id="cd18186">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="284" mass="33352" checksum="2FFF8CFBA095042D" modified="2016-10-05" version="1">MTGQKRRAVDSVELAEQAKLKIKVRLEIRKKQEVHRSISARVIIGSPQVEIWVGEKQQAFIVHQHLLTLHSGYFNRRFSIDEEDEKIQLPEVQPKRFTDFVSWMYYGTLLDTDVTESETAGEDNWALGSFLEAPSFQNHCMDDCFRHACRDERRHFVYVTSIESVYKATEKASVARKFTTDLMNCLNPLKKLKEGSEKWNDWTAMLERCPDLKADMENAVRQDWNGTYPWDCQYRDSYMVEEFNLGERWEEQILARRSLEQITMDAATGEMKSVLQLSHLKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9A2</accession>
    <name>A0A194X9A2_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">COP9 signalosome-like protein complex subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_707224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0003690">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="558" mass="62560" checksum="1CE6858F2EABF0BD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9L0</accession>
    <name>A0A194X9L0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_684853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071169.1">
        <property type="nucleotide sequence ID" value="XM_018214973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9L0"/>
    <dbReference type="GeneID" id="28824699"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684853"/>
    <dbReference type="InParanoid" id="A0A194X9L0"/>
    <dbReference type="OrthoDB" id="4492972at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="25214" checksum="5CDFB6D2A1E80A8B" modified="2016-10-05" version="1">MALFNPFYGLILPFLFIFTIPIAILASITTACAFSVLLFRVTLVYIELALAVIPHWLLGGEITAKQLRRTKSLTNTSPGRRKRRRGSTSSNASATGMLTPVSSDNVMGLSAGPTRDYEGVGGWRIDNPSDDDALWTKINSRLELPADHVRRHHRSLTSGSMPGESTAKVNRSYSPEAIMNTSRARTPPSSAIIGRDEGYFPQIPISSKTSKRNSSSTGSTTSSKGSGLCIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9L7</accession>
    <name>A0A194X9L7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_647061</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070822.1">
        <property type="nucleotide sequence ID" value="XM_018211941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9L7"/>
    <dbReference type="GeneID" id="28821667"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647061"/>
    <dbReference type="InParanoid" id="A0A194X9L7"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="679" mass="75620" checksum="4226D574E432839B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAD5</accession>
    <name>A0A194XAD5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_669190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071082.1">
        <property type="nucleotide sequence ID" value="XM_018213076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAD5"/>
    <dbReference type="GeneID" id="28822802"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669190"/>
    <dbReference type="InParanoid" id="A0A194XAD5"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="202" mass="21638" checksum="8C8F2EADFE01AFFE" modified="2016-10-05" version="1">MAFRPERATRPAVYIAARTQAIGRARRHGQTRPVFVYNLLTAGTIDVDYLGGCGARLFITISSSLYGTSSFEGGGGYGGGNGGVVVVVVGKKDPAGPVPNVSIYDVQSAENGAEAAEPFDRAGVTLLPEQRRALEWMILQERKPRPFKQEQIVEAWLFITISSRLYGNSCWKGGSGGYGGGNGGVWRRFDGRGANEPSSHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAH4</accession>
    <name>A0A194XAH4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_718832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071528.1">
        <property type="nucleotide sequence ID" value="XM_018218450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAH4"/>
    <dbReference type="FunCoup" id="A0A194XAH4">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XAH4"/>
    <dbReference type="GeneID" id="28828176"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718832"/>
    <dbReference type="InParanoid" id="A0A194XAH4"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062137">
        <property type="term" value="C:cargo receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="357" mass="39213" checksum="E8C41473FAA6AF0B" modified="2016-10-05" version="1">MEFRTTGFNGYAVKYSPYFDNRLAVAASANYGLVGNGRLFVLGLDASGIHAEKVYETSDSVYDLAWAESSETQVILAGGDGSIKLFDIAAPGNNPVAQWQEHNREVYAVAYNLVTKDSFVSSSWDGTVKVWSPIRSQSMLTLPTHSCTYSAAFAPRSASIVSCVSSDSHLRIYDLRTPASATNHLVHLIPAHGHAPVPGGPQRPSYEPAEILTHDWNKYRDTVIATAGVDQLIRTFDIRNPKGGPVAILRGHNFAVRKIAWSPHLSDVLISGSYDMTARVWTDGSTSATPSRPITLGPEAWGDEYGRFNAHTEFVTGVDWCLFGTEGWVATTAWDERVCVWDVRTVMGQNRTRFHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAI8</accession>
    <name>A0A194XAI8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_685117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071543.1">
        <property type="nucleotide sequence ID" value="XM_018215022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAI8"/>
    <dbReference type="GeneID" id="28824748"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685117"/>
    <dbReference type="InParanoid" id="A0A194XAI8"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="425"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="633" mass="71915" checksum="CB6FB27F49CDB380" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDB1</accession>
    <name>A0A194XDB1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_732853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072518.1">
        <property type="nucleotide sequence ID" value="XM_018219740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDB1"/>
    <dbReference type="STRING" id="149040.A0A194XDB1"/>
    <dbReference type="GeneID" id="28829466"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732853"/>
    <dbReference type="InParanoid" id="A0A194XDB1"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15957" checksum="23FA06D5C636E6AC" modified="2016-10-05" version="1">MTEHGKCHCGQTEWEVKLEDKSHVLCHCNTCKQLGGGTYSLNQIVPKDNLKITKGKPNIYTYYGDSGKAVRCYFCPNCTSHVYHHQEIMGDKIVVRTVLLDSGKNFKPSAEIFGKDRFGWEKEVATTFDVMPPSPNDKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDF0</accession>
    <name>A0A194XDF0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_41698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072560.1">
        <property type="nucleotide sequence ID" value="XM_018207378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDF0"/>
    <dbReference type="GeneID" id="28817104"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_41698"/>
    <dbReference type="InParanoid" id="A0A194XDF0"/>
    <dbReference type="OrthoDB" id="3561020at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="349" mass="39747" checksum="AACD234B8AFB2C22" modified="2016-10-05" version="1">MASGTPAGLLENLAISPKTIMAALHSSNDTISALDLPPPTMESQQDVPEMPPQFEPPAEFLKFSELPSELRLKIWDEASFFQRDINLWLKTLGELSVSAYTAEDSTTHELFKSHEFVTNTAPPTVLQICKESRVVGLTHYRLSFGTSYEFANLSISTTPHIYVNWDCDRICLLWPQQFQSHKSRSFKTLVNICQENRLRYLALNVLRDAHWPYVEITTAVHSLKEVLLFGSTAQKSATYSDALNIGFVNTETLAMIYPDLWRKIRNHSWAIRLEIPRRDLAKFFNLSKVGNESEGSLWVRQNVPFASNSPEIPWGLQSDLGNDEVRQPPRIETGYITINGFPELSDWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDP4</accession>
    <name>A0A194XDP4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072660.1">
        <property type="nucleotide sequence ID" value="XM_018214840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDP4"/>
    <dbReference type="GeneID" id="28824566"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684228"/>
    <dbReference type="InParanoid" id="A0A194XDP4"/>
    <dbReference type="OrthoDB" id="4971611at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19358" checksum="79CCE51C43900E44" modified="2016-10-05" version="1">MNIFTHRGVWDEHSRQSPILRFLEKYQHHIDSIDIRSTPWSKFYSCDAIFHNTRGDVWISGSHIWRKIAALFEPFDRIFHEVIELRVIPEEDGKYVAYTEFLTHFRLKGDKNEVTAPRFFVFIVGAAEDGEGTDGLVIHELSVFWDTGILTRHIEGNKKKLERKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDR4</accession>
    <name>A0A194XDR4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_615017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072680.1">
        <property type="nucleotide sequence ID" value="XM_018210709.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDR4"/>
    <dbReference type="STRING" id="149040.A0A194XDR4"/>
    <dbReference type="GeneID" id="28820435"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615017"/>
    <dbReference type="InParanoid" id="A0A194XDR4"/>
    <dbReference type="OrthoDB" id="5296720at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56320" checksum="721E6B245853F1D9" modified="2016-10-05" version="1" fragment="single">MYDRPWTKAVRDRIRQDTKRAIMAEGASTSLDADVIISGTMVEQSTLKGGMQALVSQDDAAPTPGSICTIPNELLSQILGHLDTKSISADLFDEPRLDITQASIADLKAVSCVSSLWRQIAFPILFKHARFIVPEPKDHRPAALENQIKPFLAFAIQNSLHTITESFTLIVQDANVSSIGQNPLDRFSSFWISIFDILDPLELLVAAPPEVLGALAACFMILGQSWQFRTPCQYLQLKQSKPSPTSQLKTEDNFIRAQKLLESQIREANDTGNFGPPAGQAPRNIGGSIWPDNPNNAEAEEIAFPARAERSTLLQGRPWSKLLLNEGSSIRAYASYEWWMRSPPSILSDLVGADFDNQKALISPTVRDFSYIGIFPFAKHFRDLVKFLPRLDRLYTQFVPRNQILQDPIRMAQVEATDLWSERNTAYSYLMEQLFNAPPIGSYKYLREFESGDAADKDAWNMAVQYVQRMNGEWKVEKEGVFVRDLAVIGPESDTGDNSLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDS1</accession>
    <name>A0A194XDS1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_668111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072252.1">
        <property type="nucleotide sequence ID" value="XM_018213018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDS1"/>
    <dbReference type="GeneID" id="28822744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668111"/>
    <dbReference type="InParanoid" id="A0A194XDS1"/>
    <dbReference type="OrthoDB" id="4696326at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50108" checksum="E0688B815990D790" modified="2016-10-05" version="1">MGDVREPETPRVKTALMQTIRVVNIKKPTPPPKRPYVDEKEPPSTASSSKSSFTFRVPRAPRSAPPIPRIRQSIITFSFGSKAPSLNSSLPPAEQLIFGLRRKQFYAYLGASIVLFLVSVIIGLAVLSGASKPFVPPFAGIAASTLFLPNTTQQTAALFFQDPSTNGLNLRISPDVDSLPFSPPQRLNLMKDEFPTQNLSLAATSFASMNGFGSVFHQLFYVMDASIMVMNLSCSSISPARCEIISNNMISNSLLPTMAPDSGIAAVYLEAEMGWKVFYHNDAYAISCASYENGTWNTTGIVMGSKAVRGSSIAAAVFRSNIEVLYVDQTMNMLFAVESMNGTWMPPTQVTPIQPSTFSPTSSLAISYASKADVLLAYYLGTDSNIYQFVGREASTLAFPVAISSDFTGRTTPGWTNTPTNVTGGGGGVASIGFEDQLMIFSAEGREVDMSSLNTTSGVFLPSVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEB2</accession>
    <name>A0A194XEB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_683482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072880.1">
        <property type="nucleotide sequence ID" value="XM_018214710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEB2"/>
    <dbReference type="GeneID" id="28824436"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683482"/>
    <dbReference type="InParanoid" id="A0A194XEB2"/>
    <dbReference type="OrthoDB" id="10439602at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="58" mass="6390" checksum="E4EDC02C8A93EF52" modified="2016-10-05" version="1">MHGSDCPKCGATGQSDKTCSSCGAVCTPLIRFAFSHVQLKPPWLEQLLIRSFYANKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEC9</accession>
    <name>A0A194XEC9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_498742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072888.1">
        <property type="nucleotide sequence ID" value="XM_018207944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEC9"/>
    <dbReference type="GeneID" id="28817670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_498742"/>
    <dbReference type="InParanoid" id="A0A194XEC9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="20785" checksum="4129CFF07C1BC3A0" modified="2016-10-05" version="1">MHLRLNLFVSDLLKGTLLSCSNNPSHTKLHDSISHSSKTTQIVSKNETNNCRTLRPQTPLVTERTFRETSKRKVPYFAAQLPKVSAPRMHSHLGKLSRRQPRKCQPTSNAELSSSPLRFPIPPNTSHSRNNALRNMSKANVIMRLMLTARGSALPSSSCPEDRHDAKTASYHHCQHTRLLTVFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XER5</accession>
    <name>A0A194XER5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_643046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072996.1">
        <property type="nucleotide sequence ID" value="XM_018211781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XER5"/>
    <dbReference type="STRING" id="149040.A0A194XER5"/>
    <dbReference type="GeneID" id="28821507"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643046"/>
    <dbReference type="InParanoid" id="A0A194XER5"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268205" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="67"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="418" mass="45738" checksum="546855BBDF6F422C" modified="2016-10-05" version="1">MQSFFKLTAAVLLAGTVLAVPLGPGQHAINYNVDVGVRPYYIINNMTDGALKETLTACENNKKEITQFTIGHRGGGTLQFPEETVESTMAGARMGAGILECDVSFTKDRGLVCRHSLCDLHTTTNILLHPDLAQKCVVPFTPANGTSPANAVCCTSDITTAEYLTLCGKQDGFNASAKNVKDYQYGTPTWRTELYDTCGTVMTLDSYITLVESLPGYRNFTPELKTPPAPYVIMPFNGYTQEQYARDMLNTFINRGIDPSRVYAQSFNPPDIFQWIKEYPDFAKQAIYLDEDGDTPATLTNATARLSSLAAQGVKIIGPPFGYLLNTTADNTTIVPSDYAKVAKQSGLDIIAWTFERSGPLANVAATGEYYYSDIAGAIHYDGQLYEVLDVLGRQIGIRAMFTDWAATVTYYANCMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFJ0</accession>
    <name>A0A194XFJ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_508604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073315.1">
        <property type="nucleotide sequence ID" value="XM_018208054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFJ0"/>
    <dbReference type="GeneID" id="28817780"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_508604"/>
    <dbReference type="InParanoid" id="A0A194XFJ0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="8484" checksum="DA48465FD229D73C" modified="2016-10-05" version="1">MFSFLFAGAVLLEHQVPGYQVLTFLVPECYSIGCLHDARSCFPHVINYIKDSTVISIISELRMTESPRYFDPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFV4</accession>
    <name>A0A194XFV4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_582305</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ19009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073364.1">
        <property type="nucleotide sequence ID" value="XM_018209157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFV4"/>
    <dbReference type="FunCoup" id="A0A194XFV4">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFV4"/>
    <dbReference type="GeneID" id="28818883"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582305"/>
    <dbReference type="InParanoid" id="A0A194XFV4"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="49"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ19009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="552" mass="61303" checksum="0C4D7C6FA513A37E" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG14</accession>
    <name>A0A194XG14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_643143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073067.1">
        <property type="nucleotide sequence ID" value="XM_018211788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG14"/>
    <dbReference type="GeneID" id="28821514"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643143"/>
    <dbReference type="InParanoid" id="A0A194XG14"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF43">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ18712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="501" mass="56424" checksum="2F611188D00D290E" modified="2016-10-05" version="1">MDKDKKNYEVNTAPSTSSYVGVSEAMPQKVPLGKQILYHLWDADQQLKSPQERALVRKLDFGILICSTLRWSMKYIDQSNLTNAYVSGMKEDLNIEVNEYTYMLMCYTIAFAIMQIPSNMIALKVSSRICLVVCEFGWTAFTFAQAAAQNSTHMYAFRFMIGIFEFGFSPIIIFLLGCWYTKTELAKRIAIWHITGFFGQATSGFLQAGIYSSLNGHLGLAGWRWMYIICGCMSVPVAGSVWFLLPDYPHNTKAWYLTEDDKRIALERAAKQGKAEVTGVMDLKLVKRMFGSWRWWVLVLMYIFYGNSCQANNYFAIYLKAEGYSVTQRNVIPACANIVSMVTDFAWGFMSDLTQNRAWWITGPLLFTTVIGSSTLTAWPAADAARVAAFFFVSRGYVTAVTWTWANEINVGNAQERALTISSMNGIFYATNSFLPILIFPQTEGPKFLKGFPSILAFALLAIILVFLADYLHKRQLKQEVEAALASPPSEATDRDVSNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGK8</accession>
    <name>A0A194XGK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_667957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073262.1">
        <property type="nucleotide sequence ID" value="XM_018213006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGK8"/>
    <dbReference type="STRING" id="149040.A0A194XGK8"/>
    <dbReference type="GeneID" id="28822732"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667957"/>
    <dbReference type="InParanoid" id="A0A194XGK8"/>
    <dbReference type="OrthoDB" id="4764735at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="354" mass="38669" checksum="7B740A842B744841" modified="2016-10-05" version="1">MGDIQSEAPTKQSLPSETLPNGSPISSPPVGTPSSEASSIDEPSIATLPDDSSDQEMSEKKECELANLLGSFRAGRWDPYCCPTAYELVYNRVYRRIFEEYSSSVEALSHVNVTFGPLGAYFCTVKDGLFYRDIPPSLVSKLEAVEVEPRQVALGRGNAWVAIWKDGTFSYNLGAHYSDLADALNERFNENAEIAFIALNPYDNDSWFMVDCNGFCSWNFKNMKRDQIAEIRKRTLSYLQRRSRRTGTSYTSVATTGTKTVSIKVTPETSYDEPAKSLLQRAQRLADFRIQTGNGHSIGLPQALKRPAVAAGCVAGVSTTVLGRAFGLRLGSALNLGVAAGAIACTVVSQNMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHC4</accession>
    <name>A0A194XHC4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_717078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073965.1">
        <property type="nucleotide sequence ID" value="XM_018218315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHC4"/>
    <dbReference type="GeneID" id="28828041"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717078"/>
    <dbReference type="InParanoid" id="A0A194XHC4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30420" checksum="89B41B80AE57D1A8" modified="2016-10-05" version="1">MDYQSVWLEIKEDFFSQTDKSKYPEYTARDLERLFEFFSQEANNAFPNETSPDQQCRAEYNVWRIIWSEKEAPPFPGVIPAGLEVDIWMNPPSYLENEDIWSTLATVGITNENEGTEDEDKQELFAASGVNHNTKHDWSIGLYNDGCPNCYARDHKEFECRKTCQQCSGPHTISDCHMSQNSEWGKEALKTEEPDVEDEVKMLKERIRELEDEVALLKTTNTVPKAVVIKRERDDDGYDGYDGYDGHDAESHKRVKMESGYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJD9</accession>
    <name>A0A194XJD9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_580057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074232.1">
        <property type="nucleotide sequence ID" value="XM_018209042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJD9"/>
    <dbReference type="GeneID" id="28818768"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_580057"/>
    <dbReference type="InParanoid" id="A0A194XJD9"/>
    <dbReference type="OrthoDB" id="10044044at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="24659" checksum="DDF8E9EF535BBE27" modified="2016-10-05" version="1">MADPPSTEAEILKQPNDQEPLCDKTSSSSSSSAPPPEERKEEQPKLPKLSAADFRTYNSMAEHMEYFHNHFRQTWTLLHTACTTNTRPRNLSLRQFLQTGLQFISHLETHHSIEEAHIFPVLARKMPEFKNKAELLRQHQEIHKGMESMGEYLERVRDGECELELRVLKERMDGWGEVLWRHLDEEVKTLGAENMRRYWTVEEMRRMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKJ3</accession>
    <name>A0A194XKJ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_579510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075033.1">
        <property type="nucleotide sequence ID" value="XM_018209008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKJ3"/>
    <dbReference type="GeneID" id="28818734"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579510"/>
    <dbReference type="InParanoid" id="A0A194XKJ3"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF85">
        <property type="entry name" value="A, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268387" description="Carbohydrate esterase family 16 protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36398" checksum="54A29C352878383C" modified="2016-10-05" version="1">MPSTVVAVLATAFGLQSSVQAAAIHHFSSCNATSNWPGWAGIKHAFIFGDSYTTTGFNASLTQPTRTNPLGNPTYPGYTAANGPNWVDFLTVKYNASTLLTYNLAYGGATINSALVAPYLPTVSSVAQQIENEWFPAYASKPSTAPWNAQDTLFAIFDGINDVGNSWSKGLPATTTLNGAIFAVYRGLVDELYYAGARNFAFLNVPPVDRAPLALANSAADQATEKADIAAWNSALMEMAKSLKAKKPDVNVFTVDTNKYFTQVLDKPSSYPQTAGYKNTTAYCTAYENGTPQPDSFNLSCGIPVNQYFWLNSLHPTYPMQDVLAEAVAEQLGLGPNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKK9</accession>
    <name>A0A194XKK9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">LY89DRAFT_682352</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074999.1">
        <property type="nucleotide sequence ID" value="XM_018214492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKK9"/>
    <dbReference type="FunCoup" id="A0A194XKK9">
        <property type="interactions" value="1317"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKK9"/>
    <dbReference type="GeneID" id="28824218"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682352"/>
    <dbReference type="InParanoid" id="A0A194XKK9"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KUJ20644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="447" mass="49810" checksum="5506F0DCC0979CE3" modified="2016-10-05" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDASISEGEEEYEEEAPLEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLA9</accession>
    <name>A0A194XLA9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_420878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075318.1">
        <property type="nucleotide sequence ID" value="XM_018207407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLA9"/>
    <dbReference type="STRING" id="149040.A0A194XLA9"/>
    <dbReference type="GeneID" id="28817133"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_420878"/>
    <dbReference type="InParanoid" id="A0A194XLA9"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16650" checksum="F2AFAA1C85DB29A5" modified="2016-10-05" version="1">MAHTYASEYPAGLNVDHGIKTFFEDFYKISDTGTEEAHELYADQFTADATLVMASKVRKGRDEILQIRKGMWEKVASRLHRPVKIFPFGEGAEEVMLYGTVKYVLKDGRKADVEWGARANLVKEEGKWKMGFYQVYLDTAAMQNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLT2</accession>
    <name>A0A194XLT2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_778754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075493.1">
        <property type="nucleotide sequence ID" value="XM_018222237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLT2"/>
    <dbReference type="GeneID" id="28831963"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778754"/>
    <dbReference type="InParanoid" id="A0A194XLT2"/>
    <dbReference type="OrthoDB" id="5356721at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="467" mass="50859" checksum="FDF8070C1079D201" modified="2016-10-05" version="1">MEAPAQALTSFMNETKESSSQQYNDAHLIQTSKSDVQTSSPRSKRLRLNRTTIAFFIMGILIALPTMVVTMAANQMFAGITGVYGISLSLTAAITSFSTPLFARFLPYNICTFICVIFSLLSYTICTLPFPSPSSSITTSKAGPVLGTMFAGFVYAFGTNTYLAVAAFFPQEAVLALSVGSGFAAVLGPATYMGFMVAFGQDWRRSFLVFLPTVLGILVAWWVLMNRKCREAAKRSRLGSRGGKTIESMTSEAERDTGSEGDTESATAAGKVERKEGVCIQERESDTSEMLKTGFSPHRTRLGLLFQIILPKYVAPLIICTTSAVETLARFREAPKGDLQFQISSPTETHNLSSAPSSLFYHIPFIWTWTILQLILLTIGIIQLYHPFLTYYEVWVMVMFLVGGCVGGGFISTNYKVAEDFRKAGEPDEVRSFAMSYAGLGNFGGDALGGGLAVLLQQLVVKSIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMK7</accession>
    <name>A0A194XMK7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2306 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_610080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075845.1">
        <property type="nucleotide sequence ID" value="XM_018210541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMK7"/>
    <dbReference type="STRING" id="149040.A0A194XMK7"/>
    <dbReference type="GeneID" id="28820267"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_610080"/>
    <dbReference type="InParanoid" id="A0A194XMK7"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36912" checksum="A9ED6F7169938C42" modified="2016-10-05" version="1">MRKVYRPLGFSKGYNFPLFVIFAGAIFGFVLARISYLNVTGTSARSFRKSAAPGEWYFFHQGHYRVGIILHLAGCLPAGFLAVWQFVPVIRHKALLFHRINGYVVILLSLIANAGALMIARRAFGGGLDVQSVVGVLAILTTTSLALAYYNIKRLQIDQHRAWMLRAWFYFGTIITTRLFMLASAAIITRSGNYYQVQTCGEVAFNFGGAWTNPRTLPPPTLKMYPQCVNGTNDTPIVVNANMNGLPEQIGAGLGLSFGMALWLALIVHALGVEWYLWLTPAESARLRNVSYERQLEAGFRNPGNAGLTVDRWGDAPAFQPTKTVSLKPMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMY5</accession>
    <name>A0A194XMY5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_778753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075492.1">
        <property type="nucleotide sequence ID" value="XM_018222236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMY5"/>
    <dbReference type="STRING" id="149040.A0A194XMY5"/>
    <dbReference type="GeneID" id="28831962"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_778753"/>
    <dbReference type="InParanoid" id="A0A194XMY5"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35012" checksum="4C4DD87E5EFC2C91" modified="2016-10-05" version="1">MPPHPLDDDVQLNFTYPLYKHETNAWLSSTEAFVRGVFACGKGADKKVQARVKAIFGYTPEDGYLVICDRTLFCPTGEQLCDLGLIHSHYSTPEEGPNTVFTVQDVRKKLTDEVYDHFGLYEPGVVYHLGTFEPSHVPFRVHQAVMQQIDPERRLLHSRTHAAGHLIAVAVQRLHLRGALSGDLTFNGVDRSPNLVVELGGMLDRKHRQAKRDIQREINEIISKNVRLETRRWNWQEALERGVRLPPKSETTIELMRVITLEGNEGLYLCGAPFVANTGVVGRVQIKKLTVHKKEEVTRIEYSISQNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMY6</accession>
    <name>A0A194XMY6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_639433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075804.1">
        <property type="nucleotide sequence ID" value="XM_018211621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMY6"/>
    <dbReference type="FunCoup" id="A0A194XMY6">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XMY6"/>
    <dbReference type="GeneID" id="28821347"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639433"/>
    <dbReference type="InParanoid" id="A0A194XMY6"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="388"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ21449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="570" mass="63716" checksum="1DE3D4CE8ED2AC45" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQB1</accession>
    <name>A0A194XQB1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_574935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076738.1">
        <property type="nucleotide sequence ID" value="XM_018208774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQB1"/>
    <dbReference type="FunCoup" id="A0A194XQB1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="GeneID" id="28818500"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574935"/>
    <dbReference type="InParanoid" id="A0A194XQB1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="37925" checksum="FED5CDFBACB461A1" modified="2016-10-05" version="1">MSKTQAIVVQKKGDAKVTEVSVPKVRDDYIIVKTKAIALNPTDWKHIDFLCEEGERIGCDYAGIVEEVGSKVTKGFKKGDRVAGFVHGGNMVEHEDGAFANIITAKGDIQIKIPDNISFEEASTLGVGITTVGQGLYQSLKLPLPNKPSSSTEKKYLLIYGGSTATGSLAIQYAKLSGLNVITTSSPRNFDYVKSLGAVAAFDYNSPTCSQEIKDFTKDSVTLAFDCIAEGDSPKITVSAMSTSEGGTYSTLLPVPDEQVTAINDKVKNQHTLAYTVVGESFKFGTNEVPAVPADFEEGSKFWELTRELLADGKIKVHRPSVDKYGKGLEGALKGLEAMKAGQVSGEKLVFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRE1</accession>
    <name>A0A194XRE1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_714561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077210.1">
        <property type="nucleotide sequence ID" value="XM_018218140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRE1"/>
    <dbReference type="STRING" id="149040.A0A194XRE1"/>
    <dbReference type="GeneID" id="28827866"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714561"/>
    <dbReference type="InParanoid" id="A0A194XRE1"/>
    <dbReference type="OrthoDB" id="3519533at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="20854" checksum="75E469B367388463" modified="2016-10-05" version="1">MAEGLQIAQVIADLQTLQNADPTAATNLLSASKNPRPSLSTTASSRRKSSNAIPRAGTFTDAPQQARFDKLGRRIVVPRSSAGNGTGTPPPPLSRSASSFGRLNGNGNNNGFGSLGGSLSASRSGSGVGTPVEGTPDEDMKRAKTLLELFEMRGKFKQMGDTGLTRAKQRVDNVVEKYAKMELEEREKAAKARHLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSG6</accession>
    <name>A0A194XSG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_574007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077600.1">
        <property type="nucleotide sequence ID" value="XM_018208716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSG6"/>
    <dbReference type="GeneID" id="28818442"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574007"/>
    <dbReference type="InParanoid" id="A0A194XSG6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="541" mass="59856" checksum="77544AB3F4A66647" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSW2</accession>
    <name>A0A194XSW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_728000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077586.1">
        <property type="nucleotide sequence ID" value="XM_018219220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSW2"/>
    <dbReference type="GeneID" id="28828946"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728000"/>
    <dbReference type="InParanoid" id="A0A194XSW2"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="530" mass="59976" checksum="B89FCB5F563EB967" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT22</accession>
    <name>A0A194XT22_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_170525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077549.1">
        <property type="nucleotide sequence ID" value="XM_018205565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT22"/>
    <dbReference type="GeneID" id="28815291"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_170525"/>
    <dbReference type="InParanoid" id="A0A194XT22"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15455" checksum="BCDF29D618917FC5" modified="2016-10-05" version="1">MKMSTSLERVSALLTRAMSLSNAHIVTRTVPSHATGSSSISVPNHTAAKNTATDAANFSRLGACLTALPVDEKYILPNLLACPITRHVSMIHPSHLKTSNNAKAEVEAEAQRKMRREVHLRWYRGVSEIRYDQCTTAAKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU29</accession>
    <name>A0A194XU29_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_754960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077567.1">
        <property type="nucleotide sequence ID" value="XM_018221338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU29"/>
    <dbReference type="STRING" id="149040.A0A194XU29"/>
    <dbReference type="GeneID" id="28831064"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_754960"/>
    <dbReference type="InParanoid" id="A0A194XU29"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ23212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="300" mass="33758" checksum="92E688CC9502E39A" modified="2016-10-05" version="1">MGSVVNKRRGVATGNNDDEDLLFGQAFDAFDFKTLKRILNIYHKKTKPEETARELFERLKRLEVELEARDRSTIRQSLENEEVLTRKMLRDGPRANPNLQNKMSNTGANNSLVEESKVFCSICATDVLASEVPASHPGCLDVTVAGKLYACKTCIERHIKTHQVKPFLSGDTLLKYARYVELRPIRHHSNFTWCLNLKCGHGQIHHKGLAEPKVICKKCSHATCFKHQKPWHAKLSCEQYDKSLSQGDRAAQSDSLEETKKSSAPCPTCKTQVEKIGGCSNVYCLCGTQFNWDAAMSTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVF6</accession>
    <name>A0A194XVF6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_634007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078471.1">
        <property type="nucleotide sequence ID" value="XM_018211371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVF6"/>
    <dbReference type="GeneID" id="28821097"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634007"/>
    <dbReference type="InParanoid" id="A0A194XVF6"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="339" mass="36298" checksum="03008BAD0854E980" modified="2016-10-05" version="1">MRGIQIKEYVEGPSDLKVTSLPDPTPARDQYTIGIHASATNFFDLLQIAGKYQHQPPLPWVSGSEFAGVILAVPSALPNNRTPKYKVGDKVFGASQGGYATKVCAREEALKPVPKGWSFFEAAGLFVTAPTSYGALVTRAGVKKGDWVLVHAAAGGVGLAAVQIAKAFGATVIATAGTQHKLDVAKSFGADYGINYGEANWPDQVKKLTPKGRGVDIVYDPVGMIDKSTKCIRWNGRLLVVGFAAGSIEKVAMNKVLLKNISIVGIHWGAYATNEPEQIEPVWNGIFKLIDEGKFRGTVFTDKEFVGLESVPEALKSLGSRGTWGKVVVKVPQEGQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVG9</accession>
    <name>A0A194XVG9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_679359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078486.1">
        <property type="nucleotide sequence ID" value="XM_018213852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVG9"/>
    <dbReference type="FunCoup" id="A0A194XVG9">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="GeneID" id="28823578"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679359"/>
    <dbReference type="InParanoid" id="A0A194XVG9"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000024">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="342"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="418"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="565" mass="61153" checksum="93A8E217BB13FDA1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVY2</accession>
    <name>A0A194XVY2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_548631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078748.1">
        <property type="nucleotide sequence ID" value="XM_018208274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVY2"/>
    <dbReference type="GeneID" id="28818000"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_548631"/>
    <dbReference type="InParanoid" id="A0A194XVY2"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ24393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13605" checksum="BFCEB02601024225" modified="2016-10-05" version="1" fragment="single">FAMCIPFQYNWDKKIKGGHCIDQQMFFRWATVPNIVTDLVMFFLPMPAVWGLHLPTSQKIGVTFTFFLGSVYFIRLHAFKDLTWYSVDTYTWTVIETGVYLIATCLPSLRSLIKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWA5</accession>
    <name>A0A194XWA5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cutinase gene palindrome-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_572669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078935.1">
        <property type="nucleotide sequence ID" value="XM_018208652.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A194XWA5"/>
    <dbReference type="STRING" id="149040.A0A194XWA5"/>
    <dbReference type="GeneID" id="28818378"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_572669"/>
    <dbReference type="InParanoid" id="A0A194XWA5"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="261"/>
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        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="464" mass="50868" checksum="9B0550024D54AF20" modified="2016-10-05" version="1">MPPNGNDTSMTGMLDESMLDEYDNVPMSLDSNTLDLGNSHKSYTPLSSAIPHTSADASEERSLVAHNLGDSPMAGVGAGPLPTGFGAQSTLSGSTLTEFTKRRNWSQKVVEELKDFLHILTPDGRIVYISPSGEPLTGYAREELIGTFMSTHIHPDDDAIFVREFNESIATGNPMRFFYRFKKKDKSYTIFESHGHPHLSSEASQFGLASSAASFCKGVFMMARPYPTKNAALLDSFLEHKIENERLRKRIEDLKREEAEEAEESRKNWAKKQEGGSIHPSEQTDTIDSASTPMHHTMTNPDAFAMPPPAKPSAATQALTRQNLEDVNAGNRPDSITDKMARYEGATHIDTIEMLTGLRYQDGERSRGISTGEHSPALIRGDAGIAIPIDKEARAGDKKKKIKMPDEYVCTDCGTLDSPEWRKGPSGPKTLCNACGLRWAKKEKKRPGPLPPPSLPLGNSTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWJ6</accession>
    <name>A0A194XWJ6_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28822423"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_663326"/>
    <dbReference type="InParanoid" id="A0A194XWJ6"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19347" checksum="EEE566F2BA00C6A1" modified="2016-10-05" version="1">MHRAGPSMVRSIYPPWNNESEKAIVAVCSVRLPPDSSRIGQFQPEGPSPPPLQPDPENLNRDRDPRADKLFDQYTAEPEARLLHSKLEISTQVTHPAYWSRGHASKLAKWALEVADIDQVAAGVAAATMGVPFFSHLGFKLDELIEVKGYERHPESIKVWIGTREVFDAKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWU0</accession>
    <name>A0A194XWU0_MOLSC</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWU0"/>
    <dbReference type="GeneID" id="28815811"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_23902"/>
    <dbReference type="InParanoid" id="A0A194XWU0"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="105" mass="11836" checksum="866DE8A2DFBCB522" modified="2016-10-05" version="1">MWLSLGVSVAFPTILRTEQPNPRRHLRFGIRSSEFWHLDSLFRTNCLLCKTELPPCLLQKRIGVNCASRGGHQELRSHAGTVHVSIRKVCSETFDTARPILGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B231</accession>
    <name>A0A132B231_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_790483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060813.1">
        <property type="nucleotide sequence ID" value="XM_018223374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B231"/>
    <dbReference type="GeneID" id="28833100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790483"/>
    <dbReference type="InParanoid" id="A0A132B231"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF9">
        <property type="entry name" value="EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="236" mass="25899" checksum="466332F1A0B0CD73" modified="2016-05-11" version="1">MKLIVAGGTGLVATEVIRQALQMSEITSVIALARKPVQLNNIDTSKLKTVIIDDYEKYPDQVKAEFAGADACIWTVAVTPMRSRGVDFAEVKRICQTCALAGFKTMVEAGPSKPFRFLYISAEGTPRDLTKKPLFMGEYQLMRGETENMMLAFSADHDGVEVCVAQPGMVTSSVTFWRTAQAILFGFTNIFTRAIPNISRTELATAMLGQVIRGFKKEPLTNADLLRLGRVGLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3B7</accession>
    <name>A0A132B3B7_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_790576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018223383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3B7"/>
    <dbReference type="STRING" id="149040.A0A132B3B7"/>
    <dbReference type="GeneID" id="28833109"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790576"/>
    <dbReference type="InParanoid" id="A0A132B3B7"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43496" checksum="6B9454BF353A346F" modified="2016-05-11" version="1">MEKAKAAVGNFLSKDGKHDTTVHETVNPAVQQEHVTPTRHENVTTAVDREVHQDHHHTSVQPILHKEVLPEQHTHQMGGVEHRNIKHGNDSHVKDRLAAEAAQFKNTREVGETQHTSAAAPSVAGEHVHHHVHENIQPVVQKETVQPSVVHTTVPIHEVHQNEAKHHTATSLPPVSMAEFNKQGGSLTGREERTDAFGGEPRSVGGTLGGAGARGTTSLTENDTTRSGHHSGNHLGSTGTTGTTGSGLGSSTTGTSGTSGYDSTGTKTKPSMMDKLNPKKDADVKAIPGREIICAVCTADSIRTRFNNSSSESPHNPLFLLVKISASRYSHLTYPITTTLKAPLPIPLQAPRHIRKPFINTSEIQASSFLFQSDALSEAHGVDVQQRLARLDEMHFGSRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B421</accession>
    <name>A0A132B421_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_633029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060772.1">
        <property type="nucleotide sequence ID" value="XM_018211325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B421"/>
    <dbReference type="STRING" id="149040.A0A132B421"/>
    <dbReference type="GeneID" id="28821051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633029"/>
    <dbReference type="InParanoid" id="A0A132B421"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="339"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1136" mass="128190" checksum="17E469D2046F8F2E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B470</accession>
    <name>A0A132B470_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNF7 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_790118</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B470"/>
    <dbReference type="FunCoup" id="A0A132B470">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B470"/>
    <dbReference type="GeneID" id="28833060"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790118"/>
    <dbReference type="InParanoid" id="A0A132B470"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="398"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52726" checksum="CE1DFF5DE739836A" modified="2016-05-11" version="1">MSELLTYLQNNEPQFRKARLAALYSDFRYLLTTNPDGYSANLSAWRTGLSSAAKAGVLPNGDHFSITFDEELLRSLETKEWGRPLSLGTVVREAVAGAKTGKGEGRWWMEKEFLEKEDSVYTKGWGINIQVPGPGDVVRWGLRQLGLGGNEDRLVTGKVVVLENLEEAGREAQKRLEGPRGRIERILSKDEFKEKVEDVFGEKKKLSGRDMELLLRFLARDKQILAYDGETVKVKAPNEKVAAPITTEDTTIASLKTLIKDLEIQTTVLSKRIDELLLTAKEAAARKNTVAARAALRSKKLAETTLVKRHATLAQLEEVFAKIEQAADQVELVRVMEGSTRVLTGFNQEVGGVERVDDIVDQLREQMSQVDEVGNVITEIGQAGAVDEGEVDDELEAMEREEREKVEAKERAEREERERQEAAETKKRLDALEEVERSAKKQSEEADVEKRLSTSTESLKRMSLDPENVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4F0</accession>
    <name>A0A132B4F0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_396869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">CBS 120377</strain>
        </source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="537" mass="59375" checksum="0F840009A6912B20" modified="2016-05-11" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">CBS 120377</strain>
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</entry>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ06687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="83" mass="9349" checksum="C298492DB94EE8EB" modified="2016-05-11" version="1">MIDLFKEQGEALLPSSELYEGSHRPKTKRSLCTPKLLTLWTIINLVSSLALISTFALQQPPTINSLLKKTSYYCTYIISTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B557</accession>
    <name>A0A132B557_MOLSC</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061162.1">
        <property type="nucleotide sequence ID" value="XM_018223343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B557"/>
    <dbReference type="GeneID" id="28833069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790192"/>
    <dbReference type="InParanoid" id="A0A132B557"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="642" mass="74907" checksum="545DF5536EF5A5C1" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5L9</accession>
    <name>A0A132B5L9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_725680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061898.1">
        <property type="nucleotide sequence ID" value="XM_018218995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5L9"/>
    <dbReference type="STRING" id="149040.A0A132B5L9"/>
    <dbReference type="GeneID" id="28828721"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725680"/>
    <dbReference type="InParanoid" id="A0A132B5L9"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="246"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="50978" checksum="EE1F751F4381B902" modified="2016-05-11" version="1">MTTVERYRPPHHFHSDAPSNDRRPHSSANPITKDIPPAVPSPPRLFTRTSPPRRPQVPPIPSPISKMADDESSQWIFTDEEMLSTPSILDGITPVEERCRRAKGVNFITQAGILLKLPQLTLAVASTFFQRFYMRRSLVPERGGIHQYLPRSQSHKQLKSKEGSLTLTPEQSIAATALFLATKTEENCRKTKEIVIAVAKVAQKNASLIIDEQSKEYWRWRDSILLYEETMLEELTFDLVLKSPYTVLYIFLQQLNLGENKLVRNVAWAFLNDSCMTTLSLTQTAKDIAVAAVYFALKFQNESIPDDEYGTAWWETLGGNPEIITKAVDVLTTFWSENPLSRKDIPYAENPVSGDDLEQTRRRESDGSSTSVASQNGDAKRSPEQKPTPDEKPSPEDKSRPDTKLSPEDQPGTEAKPSPKRKLEEAEIEEGEEPEPETKRAKTQESTQSQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7F8</accession>
    <name>A0A132B7F8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_659201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062538.1">
        <property type="nucleotide sequence ID" value="XM_018212506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7F8"/>
    <dbReference type="STRING" id="149040.A0A132B7F8"/>
    <dbReference type="GeneID" id="28822232"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659201"/>
    <dbReference type="InParanoid" id="A0A132B7F8"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000008">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="188"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="514" mass="54616" checksum="4E942705E62632A6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7I9</accession>
    <name>A0A132B7I9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_702382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061992.1">
        <property type="nucleotide sequence ID" value="XM_018217249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7I9"/>
    <dbReference type="FunCoup" id="A0A132B7I9">
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="344" mass="37928" checksum="B66A55B9CCD74BC8" modified="2016-05-11" version="1">MPDSSAPTTSNLVYFGSRIASAAISRLLTAPFRWRSWNGAPVVYKDQEPKPLHLKENDTIAHWIGEEDADIVILFLHGGGYTQPCSHGHMQYFHRLVTDINNLPDSTLSITVLLLAYTLAPEAQFPTQLKQATTLLSYLLKEGSRPASSILIAGDSAGGGLSLSLLSHLLHPHPDIRTLNLNAPLRGVFLYSPWVSFDTSQDSYARNAQKDSLVPNVPRKWAGMYLGTGEGEVDPGITMGGDSYSEPLLGNASWWEGMHEVIRDVWIFGGKDEVFIDSMYAFQAKFCMGWVAGGGVEERVVVGFVEAEAHIGPVMDVLLQYKKKSVTQLRFEEWLKGCLAEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7T4</accession>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="176" mass="20008" checksum="04CBA70D1D4B48B9" modified="2016-05-11" version="1">MCQVPKMLLPVTIANLLHQQNPHKRSVSTSAVSRHDSIRASAQQHIRRSMSEKQSSANNTIRYTRPTGPELVSSKHPSCLGLPLAWTSIHDQFIAYMATHAPLDKNGNIPRHEEKKERWKTADIAQELVVRFPRLGGHIKPSVIEKRLILLDQAGDNDYFKMPYSAYAYEEWGRGI</sequence>
</entry>
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    <accession>A0A132B852</accession>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A132B8M4_MOLSC</name>
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            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
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        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
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    <dbReference type="InterPro" id="IPR036864">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="47"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ08746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="513" mass="59091" checksum="7E2D05E724ACAB23" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8W7</accession>
    <name>A0A132B8W7_MOLSC</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28819807"/>
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    <dbReference type="OrthoDB" id="1263307at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="27605" checksum="6ADDE3D221327DAC" modified="2016-05-11" version="1">MSPSKPTIIVLHGSWHSPPHYERLTSLLTEAQYPPICPTQPTFDAKPPTKTLYDDADFVRSMLTELVEQEQKEVILVLHSYGGVLGTQAVTEDFSRSAREKKGLKGGVIHLLFMTGFVLHNGECLASPLGGSLPPFIPVEEDGSCNMLEPARRLYNDLPTAEQEHWVSLLRPHPEIASLTPLTNVGYKYVPSTYLFCENDQALPLEVQKSMVASVEGEVFGGKMGEVSCGAGHSPFLSMPEKVVEVIDGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Z9</accession>
    <name>A0A132B8Z9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre protein translocase Sec Sec61-beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_690849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063237.1">
        <property type="nucleotide sequence ID" value="XM_018216183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8Z9"/>
    <dbReference type="FunCoup" id="A0A132B8Z9">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8Z9"/>
    <dbReference type="GeneID" id="28825909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690849"/>
    <dbReference type="InParanoid" id="A0A132B8Z9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ08882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="113" mass="11528" checksum="2BAFADD9266D9E1B" modified="2016-05-11" version="1">MSSPRPSSPVNSPAGALGSSTGRPSSPTPPGGPKTAIRRRAAADQKDKVANARPSSTRAAGAGGSSSTMLKLYTDESPGLKVDPVVVLVLSLVFIFSVVALHIIAKVTRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9L2</accession>
    <name>A0A132B9L2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_724507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063298.1">
        <property type="nucleotide sequence ID" value="XM_018218906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9L2"/>
    <dbReference type="STRING" id="149040.A0A132B9L2"/>
    <dbReference type="GeneID" id="28828632"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724507"/>
    <dbReference type="InParanoid" id="A0A132B9L2"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288043" evidence="9">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="69"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="248"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ08943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="453" mass="50269" checksum="8D88E35A0A45CEEB" modified="2016-05-11" version="1">MKTSWLTILPVWLLGTIVTASTPLQYCSVDAEEKTDLCFAVASFKNSTTQANDLSLHISTKFVVDATGWASVAIGPKMDNALMFIMYPGGEQGRITVSTRTTRYHAIPKVVSEDAPETHVTKTWIDDTGLYNAQIMCYNCESWSGTTLDVMSPSQPWIWATNWDQPTHSDDVHLKLRPHNAKGFTMLNMASSYSESGDIIAQVSTQRITQEPNTDDAGPAPPTMQDESDDHHPAKEHHKHSAFGLVSLHGFLLSFGFFALTFGVLGIRSGSSKSYKIHWTIQTGGGSAIVVGCLMGIYLSYKHGGHFGTFHQWIGLSMIPSVIIQGLLGYLHHVNYLKYGRRTAVSYYHIWLGRAALIIGNLNVGFGLNLAGAESFKWFTWYAGLAIQLSVLIPMWYFYARGKTILDAVRNKPVAKDVVRYESVEQDAFIVDDELDEFEDEGLGHDDLKNGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA14</accession>
    <name>A0A132BA14_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063576.1">
        <property type="nucleotide sequence ID" value="XM_018216066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA14"/>
    <dbReference type="GeneID" id="28825792"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690284"/>
    <dbReference type="InParanoid" id="A0A132BA14"/>
    <dbReference type="OrthoDB" id="113620at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="60" mass="6921" checksum="2DFE5F93BD7775EE" modified="2016-05-11" version="1" fragment="single">MIELSEDHEARMDELEGTLRGHIGLIEEALDRLEGKATDEDRGKKMDDYYGKRGRNEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAR3</accession>
    <name>A0A132BAR3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_315300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063299.1">
        <property type="nucleotide sequence ID" value="XM_018206667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAR3"/>
    <dbReference type="GeneID" id="28816393"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_315300"/>
    <dbReference type="InParanoid" id="A0A132BAR3"/>
    <dbReference type="OrthoDB" id="3557586at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="180" mass="20286" checksum="50F54DB6FAAA406E" modified="2016-05-11" version="1">MLNILDITAPMSKTISEFGPRQNDQLHQEVSSITGFSHCLKDEGENILSSSPAYSLNTLYEDYFSTPNCEQTDFAWDSEDGWHQICNLCLHERCPDCEGVIFTSVTDFQDVLTFENREIWICADCKHGFCLGRRLKLVSLCRSCGHEACAECLGRIDEIHHRPACCKCLKGAEVEVDKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAY9</accession>
    <name>A0A132BAY9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_317285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063359.1">
        <property type="nucleotide sequence ID" value="XM_018206684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAY9"/>
    <dbReference type="GeneID" id="28816410"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_317285"/>
    <dbReference type="InParanoid" id="A0A132BAY9"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="28641" checksum="ED2361561B2A3BEF" modified="2016-05-11" version="1">MAFVRSNNDDIVDGALRTPPDGGPHGSGDTHLFLEAENRGADKEGRKTGSTASHAEQKILSIGSLVNELACLGLVAASLFGIAAILWVYDGRPYPEWSMGRLGNVTLNTIISIISTAFRAALLAPVAQSISQFSWLWYTRPRSLEDAVYYDFASRGPFGSLRFLSKLHIRSLASIGAIIIFTALALDPFFQQSVKYNTRSAVDATQQAQSVAAYNYGTGFKGAAEVSDGYTSLPYNMRAAVYQGLLAGNLISIPDPPFNYPTGNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCK8</accession>
    <name>A0A132BCK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_701077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064481.1">
        <property type="nucleotide sequence ID" value="XM_018217167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCK8"/>
    <dbReference type="GeneID" id="28826893"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701077"/>
    <dbReference type="InParanoid" id="A0A132BCK8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="36971" checksum="6F9658E3C8FD552A" modified="2016-05-11" version="1">MAEPVTVELDLQDVDDLNENDSAFGDDVQSATTSIGSSILKYRQENGRTYHAYKDGKYVLPNDEGENDRLDLQHHMYCLMLDGKLTTAPIPKDQQLHRVLDLGTGTGIWAIDFADEHPESQVLGIDLSPIQPRFIPPNCMFEVDDLEEDWTYKHKFDLIFMRMMTGSVSDWPRCFKQCYDNLNPGGWMEIHDMKFPIEDNDDSFPTDCAVKQWTDFVIEAAQNLGRPLDSAKNYKQQLIDAGFENVVQVMYKWPQNHWPKDKKLKELGRWMYENFSSGLSGLSMALYTRGLGWTAEQTEAFLVEVRKSMKDPKVHRYYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCU4</accession>
    <name>A0A132BCU4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_710629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064607.1">
        <property type="nucleotide sequence ID" value="XM_018217844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCU4"/>
    <dbReference type="STRING" id="149040.A0A132BCU4"/>
    <dbReference type="GeneID" id="28827570"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710629"/>
    <dbReference type="InParanoid" id="A0A132BCU4"/>
    <dbReference type="OrthoDB" id="3926760at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="41365" checksum="963F0F4D27913D8A" modified="2016-05-11" version="1">MPPNPAAVGVVVAVSIVAAAAIAVYESPQARQFAEDVRRKIAIALHSLGDEINPQSRQPRFNRPEDAEGFLMSQAGADPGIDADEESKKRQREELMYWNAVHLEKKEKERQMNGTRPENRSRGSSFDDFLHEDPSGEKGTYVYNTGTDTNQTEGLRNRGVQGLNRGSFYANPFGDEHNIEMDEQRAIDASLMDPDMSEREEMMSDIYSANEDPRPSRQTPATIAEQLIDTSDDPVPDPPVSFPTMEDHFMGETTNFTNMATADRDDSAYASIHAWADNANHSFYSPLPVTPGAITPQQQEVRPSSPTFSDPDVSVPGSGFATPTDSASLAGSGEEIWAPRSGATSEADVMSVDGEGVSTPGTWTEVGSVVSEDDVGAGVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDD7</accession>
    <name>A0A132BDD7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative N-carbamoylsarcosine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_787448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the isochorismatase family.</text>
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    </dbReference>
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            <begin position="31"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ10416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="23857" checksum="D2AB4511CEC23193" modified="2016-05-11" version="1">MSGLSPSEYPEYAQFIANKKGSTVGYGTKPALLLIDVCKAYFTPGPLDISSYSNAASAPDSMKRLMAAAHAGGCPVIWAKTNYIHPKIRDAGLLAIKNPSLDVFRDGDSRGLNEFLEGFEPDDNEIIIHKKCPSAFFGTNLLTQLHVLWVDTLIIGGFCTSGSVRATALDSMQSGLRTMVVASACGDKSRETHFSNLFDINAKYGDVVSEQESIENLKAGR</sequence>
</entry>
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        </submittedName>
    </protein>
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            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="match status" value="25"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="213"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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            <end position="1624"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1861"/>
            <end position="1893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2073" mass="231706" checksum="C41A028553A7FF79" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDI5</accession>
    <name>A0A132BDI5_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064082.1">
        <property type="nucleotide sequence ID" value="XM_018206417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDI5"/>
    <dbReference type="GeneID" id="28816143"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_276341"/>
    <dbReference type="InParanoid" id="A0A132BDI5"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="513"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="518"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="58729" checksum="53B2D9AFF5634642" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDV4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_261483</name>
    </gene>
    <organism evidence="2 3">
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        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064788.1">
        <property type="nucleotide sequence ID" value="XM_018206276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDV4"/>
    <dbReference type="GeneID" id="28816002"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_261483"/>
    <dbReference type="InParanoid" id="A0A132BDV4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="18194" checksum="9350E92733283E88" modified="2016-05-11" version="1">MSCTCINERERDNTKCRSIYAFSARTDTRPGLFAMVWRALPGLCLSICSKMSRCFFYLVLDTLHLIHISPLLPLPPSLSQPRSLRFHDFVFLLAYLFPLCVCLSAFAFLPTTTTTTYIRSYKPCTACPSQWARLEKMMVVVVSCWRGNQGEGLCGCLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDZ8</accession>
    <name>A0A132BDZ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_787492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064828.1">
        <property type="nucleotide sequence ID" value="XM_018223078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDZ8"/>
    <dbReference type="GeneID" id="28832804"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787492"/>
    <dbReference type="InParanoid" id="A0A132BDZ8"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288128" evidence="1">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="346" mass="35935" checksum="9FCCEF2FCE93F550" modified="2016-05-11" version="1">MTGLLFIMVLCLAMRSINASCNGNNCLNALHRNKDSNSFCLNYLSLAGQPIPNYLANCHDSPSRVSSACFCYSPTPTAICSTALSSTVSISSASASITSTTLFACPASCSVSTASASTVTVTITDTLPPTCPSLSPSSIVIYTCSTTDYSSASPTLPSSNLSAAPSSAALSSTSSIASASASPTSSSSPTSTPVSIPPNFSLLGANSNTSADGQVVDGELADDYFLGFDLPYGETNLTFGIDPISQYLYINGSNNVIYVIWAINFPGGDPPMLVSLLPGDYSGYTQWPVVCTVAPTLQLSCVAQGMDTYNIFYLVDENQDGHFELAIGDYAATVNVKGPVDLFVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE18</accession>
    <name>A0A132BE18_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_266104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064272.1">
        <property type="nucleotide sequence ID" value="XM_018206312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE18"/>
    <dbReference type="GeneID" id="28816038"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_266104"/>
    <dbReference type="InParanoid" id="A0A132BE18"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16654" checksum="B3D496D58C946BBE" modified="2016-05-11" version="1">MVSSPVLQRLLPVSLSIYYNYHIGRANCLLASKHITQHKSENSSPKRIPSNPCSLHPTRSKGSSHLILNQETPRSVPFQSPVLHPRTEPCTPPPMHRTHKNPQPTNQENPSILHTHPFSTPTHPTNPFVHSEPKRKAEGWMDIFVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEN0</accession>
    <name>A0A132BEN0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_270862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064492.1">
        <property type="nucleotide sequence ID" value="XM_018206363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEN0"/>
    <dbReference type="STRING" id="149040.A0A132BEN0"/>
    <dbReference type="GeneID" id="28816089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_270862"/>
    <dbReference type="InParanoid" id="A0A132BEN0"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="19497" checksum="0D37C2A14F36C374" modified="2016-05-11" version="1">MASNTIASKLLEQNKDAAKTYQPMPLFSELSSLGLEVPHTLIITCADPRISPEKFLDLGPVGPVIIRNVCGHVAPALNDIVSLDSLVNFTDVIIVHHTDCGSLMMKNENVRNYIKKELPEAKDVDSMKFGGTIEIHQSVKDDLAILRASPLIKKDLREHSYGFILDIKTGEFITVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRQ3</accession>
    <name>A0A194WRQ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial distribution and morphology protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_626182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065033.1">
        <property type="nucleotide sequence ID" value="XM_018211099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRQ3"/>
    <dbReference type="FunCoup" id="A0A194WRQ3">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WRQ3"/>
    <dbReference type="GeneID" id="28820825"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626182"/>
    <dbReference type="InParanoid" id="A0A194WRQ3"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9357" checksum="3F028378E3437E5B" modified="2016-10-05" version="1">MSASLAPECDEVKERYDSCFLKWYSEKYLRGKGTTDECAALFKDYKRCLTSALKEKGIDKMLEEAREDHKENDAANLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSY8</accession>
    <name>A0A194WSY8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_236247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065421.1">
        <property type="nucleotide sequence ID" value="XM_018206061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSY8"/>
    <dbReference type="GeneID" id="28815787"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_236247"/>
    <dbReference type="InParanoid" id="A0A194WSY8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="60" mass="6874" checksum="982F0B3E894AAACE" modified="2016-10-05" version="1">MTSNAGAQVAKSVTSAMIVSLDQVILLFIYRSSWYKMQHDDGSIWRNFMTDRTQILARGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTG2</accession>
    <name>A0A194WTG2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_759951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065314.1">
        <property type="nucleotide sequence ID" value="XM_018221490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTG2"/>
    <dbReference type="STRING" id="149040.A0A194WTG2"/>
    <dbReference type="GeneID" id="28831216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_759951"/>
    <dbReference type="InParanoid" id="A0A194WTG2"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26817" checksum="9241ABA56221395D" modified="2016-10-05" version="1">MRTKQTKTTSKRTEPSKSKKPFKSTVKPTQEVAPSDQKAHLWEIKSPCAEPTGQWPKGVSSCNDGSWRKTITWLLTKVKDFISKRKGGCVLDIPPGNCVKFGAQVHLSEAFALRLVAEKTTIPVPRVLSAFIKDGSTYIVMEKINGITLEDAWGKMPDAERRLVMAELKDYFEQLRKIPHPRPGTICTAAADDHALYDLRIFHGDRGFGPFRARRTSIYSFGTVIRAGNQLERTTWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTS9</accession>
    <name>A0A194WTS9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_594936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065711.1">
        <property type="nucleotide sequence ID" value="XM_018209829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTS9"/>
    <dbReference type="STRING" id="149040.A0A194WTS9"/>
    <dbReference type="GeneID" id="28819555"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594936"/>
    <dbReference type="InParanoid" id="A0A194WTS9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="335" mass="36022" checksum="0236F10FB053F574" modified="2016-10-05" version="1">MATQTKLQTGAWLETPGPNARVVIRNDLPIPSPSKGEVLVKLECTGVCHSDVYGITGQTSRSTNIMGHEGIGRIVEVGPGASQDLLQKRVGVKWLYSYCNECEICEVNVTACPNQHNSGRDVPGTFQQYVVSPIEPLTMIPDTLDSAMAAPLLCAGISIYSAIMKLDLKSGQWLVILGAGGGLGHIGVQIAQRKGSKVIAVDTGEEKRKLCMDLGATCFLDFKTDDVTTEVKKLTNGYGAHGAVCLSGIRAGYELALSVLRNLSSLVPYKMAVHGFTIIGSSVGTKAQLDELLQMAVRGEITTITKVHEFEELDDLLEKLKRNQISGRVVVKIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUA6</accession>
    <name>A0A194WUA6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_674124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065896.1">
        <property type="nucleotide sequence ID" value="XM_018213412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUA6"/>
    <dbReference type="GeneID" id="28823138"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674124"/>
    <dbReference type="InParanoid" id="A0A194WUA6"/>
    <dbReference type="OrthoDB" id="5330646at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="194" mass="21232" checksum="6E1FB27296C3E737" modified="2016-10-05" version="1">MNILKPLLIITVPTPTPVTHFIDVEMENVLNPPCTMMFAPVPFGLNPGQTSVITEDVTSIGLIGVPNPAMTGPYLPTDETTVQDVYGMWLGPTPEAGGFSIEFNIVGPYPPAEGEDRASKAAATDTKTKSVKWKRVDFKALSLSELNCAERQLNEAKETFQDNDEASKLIKSWLDEVADEKKKYEPKEESKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUX0</accession>
    <name>A0A194WUX0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_758098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065814.1">
        <property type="nucleotide sequence ID" value="XM_018221422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUX0"/>
    <dbReference type="FunCoup" id="A0A194WUX0">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="GeneID" id="28831148"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_758098"/>
    <dbReference type="InParanoid" id="A0A194WUX0"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32411" checksum="E49C9EB10AB306B8" modified="2016-10-05" version="1">MSDSDSTYEAYRYNPSLGAAVAFVVLFTSTTTFHLYQMIRTRTWYFIPFVVGGAFEFIGYIGRAISSQQSPNWTIGPYLVQTLFLLLAPALFSASVYIQLGRIILLVDGEDHSIIKKRWLTKIFVTGDVLSFLTQAIGGSIMASGTLSAMHTGAHIIVGGLFIQVVFFGLFMVVAFVFDFKLHKYPTPDPAIPSQKHLKTLYIASILIMIRSLFRVVEYIEGNNGYLLRHEYYLYISDAVLMLGVMVLFNVIHPSEVHALLRGGKVSKGFRMITLNTSKLSSTSSDETGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUY8</accession>
    <name>A0A194WUY8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_688953</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066141.1">
        <property type="nucleotide sequence ID" value="XM_018215813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUY8"/>
    <dbReference type="FunCoup" id="A0A194WUY8">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WUY8"/>
    <dbReference type="GeneID" id="28825539"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688953"/>
    <dbReference type="InParanoid" id="A0A194WUY8"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="153"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="335" mass="37306" checksum="3E2E1FA14DA9F96D" modified="2016-10-05" version="1">MAPTGLYSRFKAYYTGEKDPEVPPVSTTTAVALLVLYTLIYVLPFYISSTTRPSPQLSRDAPSVIRGRIRSVTLSCIICSVTTFVILSSVEHGDPFQSLHLMGYYPIGLDETVKTVALTAILFAGPLFEAGIAEGGWRDWIRLRGVNETVSGWIGWRNYVAGPLTEEVLFRSASVPLLLLSQVSNARIIFLTPVVFGLAHVHHFYEFRITHPHTSIIAALLRSLLQFSYTTLFGGYVTFIYMRSGSLLSVILVHAFCNWRGLPRFWGRISAAETVMGPDVGEGKRSEDNPTKNSNDDKLAIVWDIAYYLILLFGAVAWYKSLWTLTESDSALTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVD0</accession>
    <name>A0A194WVD0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">LY89DRAFT_738559</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066276.1">
        <property type="nucleotide sequence ID" value="XM_018220387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVD0"/>
    <dbReference type="FunCoup" id="A0A194WVD0">
        <property type="interactions" value="1253"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WVD0"/>
    <dbReference type="GeneID" id="28830113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738559"/>
    <dbReference type="InParanoid" id="A0A194WVD0"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="143"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KUJ11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="939" mass="101109" checksum="6DEA7528745991EE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVQ3</accession>
    <name>A0A194WVQ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_654362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066022.1">
        <property type="nucleotide sequence ID" value="XM_018212297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVQ3"/>
    <dbReference type="GeneID" id="28822023"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654362"/>
    <dbReference type="InParanoid" id="A0A194WVQ3"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="204"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="58894" checksum="B23AAC06B112724F" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYW6</accession>
    <name>A0A194WYW6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_651217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212143.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28821869"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_651217"/>
    <dbReference type="InParanoid" id="A0A194WYW6"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
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    </dbReference>
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    </feature>
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            <end position="703"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        <location>
            <begin position="770"/>
            <end position="794"/>
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        <location>
            <begin position="16"/>
            <end position="178"/>
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    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="805" mass="88016" checksum="B99BE588C4DEC3E5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZP3</accession>
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        </submittedName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="4331875at2759"/>
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            <begin position="1"/>
            <end position="19"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="265" mass="27396" checksum="06D4880CB7C2C6E2" modified="2016-10-05" version="1">MHALNVALGLGASLSLCLASLHNREINDPVGIYLDSMCYPLYTNQSRTIALKLSINEMIPSLAFSPFPCEQALYLRAICIANGTTVDDFLAEQECLCHGSFFEVTAGCDDCLFAHGYQLITPQEAAGNLSSRSVAECAPTPPFQPYTNLIGVANITSASLSPPLTPGHDKFPNMTAVSNYFTETASATPGSITGSATARLTSWTNTEGNIYTPTSIPPDSGTGSASAVSTTSSGSTSQSTNVAATRGVGVVGGLLAAGVGVMAIL</sequence>
</entry>
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    <accession>A0A194WZP4</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="1177" mass="133311" checksum="EA54858948E0CAF8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X047</accession>
    <name>A0A194X047_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13573.1"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23224" checksum="143766ED3BA47ABF" modified="2016-10-05" version="1">MPPITKIWFAKIKPSTKTDSPEFHDIWTTVLQFCNQQSGKEAAGHTLWQDINDSKNLIFISGYPSQESTDAADSLYVKTHAPKLMEFVENDGIVQLSRDVTELPIKDAFVSLGLYGQGQGGGAAGFEKSSKGIQSLLQGMEGNTGTLSGKDEWPAILRRRKGLAPDTNAEDTVVVVSGWKSDQYYQSAVKRLNQQSLPPRKLSIYKKIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X299</accession>
    <name>A0A194X299_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_686777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X299"/>
    <dbReference type="GeneID" id="28825087"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686777"/>
    <dbReference type="InParanoid" id="A0A194X299"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="34199" checksum="30975464655295D6" modified="2016-10-05" version="1">MTSYVKNIALVGASGLVGGQVLKNLLAAGKFEVTAISRQESKATFPSSIAVKKGDYSSSEFLESALQGQDVLILTLAIMTPPDVQTNFIKAAAKAGVPWVLPNEYGNDGASEEVMKNIPILVGKKKYRDLIEGLGVSNWIGIATNMWIDFGLKGGRFSIDIPKRTATVYDEGTHPFVTTSIPQVGRGIAKLLSLPITSTSGLSLSDYKNKYAYIRSFLVSQNDMIAASQRATKTKPEDWEIKHMPLDDYIKAGSELMRAGNRMGMFNILYGNSYKKGCGDQYHGRENTNENIGLEDEDLDEVVQKVVDELEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2M8</accession>
    <name>A0A194X2M8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_784879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068447.1">
        <property type="nucleotide sequence ID" value="XM_018222829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2M8"/>
    <dbReference type="GeneID" id="28832555"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784879"/>
    <dbReference type="InParanoid" id="A0A194X2M8"/>
    <dbReference type="OrthoDB" id="3550792at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="830" mass="92392" checksum="112A7479F8A85264" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3D3</accession>
    <name>A0A194X3D3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_783800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069065.1">
        <property type="nucleotide sequence ID" value="XM_018222724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3D3"/>
    <dbReference type="GeneID" id="28832450"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_783800"/>
    <dbReference type="InParanoid" id="A0A194X3D3"/>
    <dbReference type="OrthoDB" id="3532148at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="36728" checksum="DF4F7F7ABCCBC03E" modified="2016-10-05" version="1">MSSEVSSQASFLFFRQLPPEVRCMIWTLLSMTEPRVVPILYQSDTTSYTARIRPPAVLQTNRECRHEALKIYHELRLGLRSNIGCYINPLTDSVYLRSNLNRASNRIDDLTVIEPWQRGRLITTSPAGDTSLGSTQSTQTEQGNTVGASSSSDVEGNTNPGMLRSRRHSKIMLDDLIHSPDAEIIFKSFHINFVTWDLMRRYYRHRRHKIPVHIKELCVVFEKGSLPLKIDFTLKEIQHIDAFPEEAPLQLETVEEKRTAWNLIRSLKKSNIFVNLRDRRSGRPIALNFPVYAKALDLGESSEWQELLSETGRVACNEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3Q2</accession>
    <name>A0A194X3Q2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_589148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069178.1">
        <property type="nucleotide sequence ID" value="XM_018209514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3Q2"/>
    <dbReference type="STRING" id="149040.A0A194X3Q2"/>
    <dbReference type="GeneID" id="28819240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_589148"/>
    <dbReference type="InParanoid" id="A0A194X3Q2"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="60" mass="6685" checksum="4B727EE67EA5BE8C" modified="2016-10-05" version="1">MSLIEASKANLPNLRQLFVNARTELEESTYSRTAFYNIVLFMSSVAVFSLVAQRVNKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X548</accession>
    <name>A0A194X548_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="9" type="ORF">LY89DRAFT_708190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069660.1">
        <property type="nucleotide sequence ID" value="XM_018217668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X548"/>
    <dbReference type="FunCoup" id="A0A194X548">
        <property type="interactions" value="1285"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X548"/>
    <dbReference type="GeneID" id="28827394"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708190"/>
    <dbReference type="InParanoid" id="A0A194X548"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="8">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ15305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="32060" checksum="048EBB53A4E01C66" modified="2016-10-05" version="1">MAPSQLPPIFNATSQDIEMLLSAQCHLGSKNLQTHMSPYLWKTRPDGINVINIGKTWEKIVLAARIIAAVDNPADICVISARPYGQRAVLKFAAHTGAVAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLVWWMLAREVLRLRGSIANRETEWDVMVDLYFYRDPEAEENKEALEEKVPGADEVGTTAIETGFAATGGDWEVAGPSATAFAGATTAAPAGAGWDATGADDWAASGTATGEWGAATDATKPAGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5Z5</accession>
    <name>A0A194X5Z5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_89069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069953.1">
        <property type="nucleotide sequence ID" value="XM_018223493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5Z5"/>
    <dbReference type="GeneID" id="28833219"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_89069"/>
    <dbReference type="InParanoid" id="A0A194X5Z5"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="29699" checksum="3B49F58CC2701FB7" modified="2016-10-05" version="1">MDSMRSLNTSLPRSTPAPSKHQDPPEPLLSAFKAAALSVTNLYKSAAVDQGRARAEGYQDALSELLSFLDKEDIGLSDGEGWRIRSWATERLDGRDSTSQNMESDDELSEKTDRGSSPVLQRSQSATRLSSTLHTTRTASPIRTESAPPPSLIPPTTSDYTTDSVPQQATFTFRSSHPYPPDADIILSDLDSSDHARPPTQDATHSSSTTGITLSRASRSRHNSHPARVNTRSVNTISRGAGQKRKINFGDFFDIGNLGHKDGFGGGGKRGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6B0</accession>
    <name>A0A194X6B0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_93794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070071.1">
        <property type="nucleotide sequence ID" value="XM_018223523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6B0"/>
    <dbReference type="STRING" id="149040.A0A194X6B0"/>
    <dbReference type="GeneID" id="28833249"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_93794"/>
    <dbReference type="InParanoid" id="A0A194X6B0"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="555"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="712" mass="79527" checksum="EDF6A77F146E762F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7K2</accession>
    <name>A0A194X7K2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_648214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070434.1">
        <property type="nucleotide sequence ID" value="XM_018211999.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7K2"/>
    <dbReference type="GeneID" id="28821725"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_648214"/>
    <dbReference type="InParanoid" id="A0A194X7K2"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1509"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="616"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1418"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="753"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1418"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ16079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1645" mass="183555" checksum="52B9F1026983D916" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7Y6</accession>
    <name>A0A194X7Y6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_586297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070633.1">
        <property type="nucleotide sequence ID" value="XM_018209360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7Y6"/>
    <dbReference type="GeneID" id="28819086"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586297"/>
    <dbReference type="InParanoid" id="A0A194X7Y6"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="35586" checksum="FC85A418C56CF847" modified="2016-10-05" version="1">MKELPLDFHLRHYTNYTNTVVFDTINAVPGLKTSAAFFSFLRANLVLPSSTLNSTTSTPLLDPSSSQTLPPLGPSTLATMSSADDAGDEVLLPPNPLEGVPELITKPLTTEDDKISALKLVADSIAQQRNIAASAIIFNPLILALYIGLMAAISQYLYKDRGDIGVVITTGAGVTMACLVAIRSATGGYLTAAEEMTWKWAQNEDGEDDIIIGSRFGDEIMGAAVLRLERSGNGGAKKKKASGKTGGKGLVRAWTVRVKYRGKGVGTELLEEAVRITREKLGNSAEIGFAAEHANSKKVLPNFFNGIFKKKEARAARALEKVVESMDGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8L1</accession>
    <name>A0A194X8L1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_749126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070804.1">
        <property type="nucleotide sequence ID" value="XM_018221169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8L1"/>
    <dbReference type="STRING" id="149040.A0A194X8L1"/>
    <dbReference type="GeneID" id="28830895"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_749126"/>
    <dbReference type="InParanoid" id="A0A194X8L1"/>
    <dbReference type="OrthoDB" id="3519926at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="28054" checksum="FD47E005188FC7ED" modified="2016-10-05" version="1" fragment="single">ELQLSCSVKTLKRRCKEAGYYSCICCQKPYLTKTQANARWLWGIAHMFWTIWEWSQILYSDEVTFQVGGKKCKQRCIRNKKERCHPDCIQFQMHRGGTIPVHFFGAVGYGYKSPLINIHGTRKSGAFTQTDYLAQFMEDGNSAHGHKTTSNICATWRTSMGITLFPHPAVSPDMNPIEKCWRRIKQALHRRLRQPTTEVQMVVAVLEEWDKIPQEWINGLIEQQDFWVHDLIKRCGWSTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8Q5</accession>
    <name>A0A194X8Q5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_87034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070911.1">
        <property type="nucleotide sequence ID" value="XM_018223471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8Q5"/>
    <dbReference type="GeneID" id="28833197"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_87034"/>
    <dbReference type="InParanoid" id="A0A194X8Q5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="401" mass="44233" checksum="EDCAAF20B14D90A4" modified="2016-10-05" version="1">MVAAMHPEFSGPSGQLVECSYMDPRIDLKAARQLLNRSDLDGNEFGTALSNLIELVKFHKADELLSSSSEILLHGSKHVTTNEQPGISESSSQVSNELSITDPTKDPDLEELDEALRISQEKGLVMKFTDPGLTWKTMRNSVIVTNLPSSGERIMKEAEQNLRDAFRIPQTVKCYMRKPRGLKLFALHATLVFDTPAEAIAMESQIDQKFFQGRVLGCRYLGYGTKNFEAHDSAKETADSMDSDAADEVTSDNHQPASENPVADDIEIVLGTAKSTSALTRLTNHLNTFVRPRQTKEEHVPPLEVSSEHVAEDERSVEVVETGNMREDEKVVPGNTDDAEKLAEGQRTKQGGQQMQDKPVENDAEDQQDIAGIRSLNPEDLNPDPSRADEGVASELMEDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8S0</accession>
    <name>A0A194X8S0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_670063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070920.1">
        <property type="nucleotide sequence ID" value="XM_018213142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8S0"/>
    <dbReference type="GeneID" id="28822868"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670063"/>
    <dbReference type="InParanoid" id="A0A194X8S0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14989" checksum="D37A92E890A92815" modified="2016-10-05" version="1">MNNIAKKCHKKNPLQFAFCQRCGVWSCEDCEVFPKPKIKRPETERIRIQRPMSEYRTSKREEKPRLQGHTGAGHRKSKLEENKRPETKRMEMQKSTSENRALTKQEQPKIVGHADSGTRRSKFQEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8W9</accession>
    <name>A0A194X8W9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_617946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070970.1">
        <property type="nucleotide sequence ID" value="XM_018210818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8W9"/>
    <dbReference type="STRING" id="149040.A0A194X8W9"/>
    <dbReference type="GeneID" id="28820544"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_617946"/>
    <dbReference type="InParanoid" id="A0A194X8W9"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="294"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ16615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="44568" checksum="1125881EF1F3C97F" modified="2016-10-05" version="1">MAGERLSSILKHLTPGSSGLSTITAKHADDVVITLAIRTPLAKGFKGSFKDTELDYLVYSLLKQVVQKSRIDPQLVEDICCGNVSDGKAAYKLRAAALAAGFPNTTAASTVNRFCSSGLKATQDIANQIASGSIEIGVAMGAEMMSIGGDRLEKPFHPEILQNQESADCMQPMGQTSENVGKDFNISREMQDRFAAESYRRAEVAQKAGWFEDEIVPITTEVKDPKTGDLKKVTVTKDEGPRWGTTFEGLSKIRPAFPDFGDKSTGGNSSQVTDGAAAVLLMKRSRAIELGQPILAKYVGATVAGLAPRIMGIGPSIAIPKLLGKFNITIDDCDIIEVNEAFASMAVYCKDVLKIPHEKMNIRGGAIALGHPLGATGARQIVTGLSECRRQKKKILLTSMCIGTGQGMAGLFVNEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X922</accession>
    <name>A0A194X922_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL Lipase/Acylhydrolase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_647306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070964.1">
        <property type="nucleotide sequence ID" value="XM_018211951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X922"/>
    <dbReference type="FunCoup" id="A0A194X922">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X922"/>
    <dbReference type="GeneID" id="28821677"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647306"/>
    <dbReference type="InParanoid" id="A0A194X922"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="260" mass="29291" checksum="A4D159D462026D74" modified="2016-10-05" version="1">MEPLGQFLMFGDSITQGSHDQSRGFGLGAELQAAYVRRLDVINRGFSGYTSDHALEVVAKVLPNPSQAPIKFLTIWFGANDANKNLEQGQFVPADRFKQNLNQIVNHPAVKAHSPHIILLTTPPFEENVLQKFQEDWGYAGEVRKAKDAAEYAELVREVGKETDVDVVDVWTLFMEKAGWKTGEPLPGSKAMGKNEVLADLLYDGLHISPTGYRVVFDALIKLIKEKWPEYRPYKMPFVTKVAWEIELGDQMWDVKNDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAC5</accession>
    <name>A0A194XAC5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071475.1">
        <property type="nucleotide sequence ID" value="XM_018215012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAC5"/>
    <dbReference type="GeneID" id="28824738"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685072"/>
    <dbReference type="InParanoid" id="A0A194XAC5"/>
    <dbReference type="OrthoDB" id="5070419at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="12893" checksum="CD970388AC2F8681" modified="2016-10-05" version="1">MATSSSNVQLALTTASSLMGIVAVSGGIYGMANPLGFSSTLGIPITSSTSPALPFVSFAAARNLGSGVTMLALLATGQRKAVGTVLLCGTVVAWGDAWVCNSSGGSGDKTVGHAVAGVIAAALGWGMNWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAH5</accession>
    <name>A0A194XAH5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_616916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071499.1">
        <property type="nucleotide sequence ID" value="XM_018210780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAH5"/>
    <dbReference type="FunCoup" id="A0A194XAH5">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XAH5"/>
    <dbReference type="GeneID" id="28820506"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_616916"/>
    <dbReference type="InParanoid" id="A0A194XAH5"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="7">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="27330" checksum="77D3738DFACA616E" modified="2016-10-05" version="1">MASTDEDRMRKQREAGERESAKLWRACRTVHEMVRDRGYQLSDAEVTMSFDAFKQKYTTDDGSISRKMMNFSASPTLEMIKRYSNPVTAHDLHPSSPDIGTIWVEFLPDSNVGIKQMRAFAQHLTANNFHTGILITGVNITPAALKIIPAVASETRIECFMEADLLVNITHHELVPQHVLLSKEERTALLQRYRLKDTQLPRIQLGDPVARYLGLRRGQVVKIIRKSETAGRYASYRLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAJ6</accession>
    <name>A0A194XAJ6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_684828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071137.1">
        <property type="nucleotide sequence ID" value="XM_018214963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAJ6"/>
    <dbReference type="FunCoup" id="A0A194XAJ6">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XAJ6"/>
    <dbReference type="GeneID" id="28824689"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684828"/>
    <dbReference type="InParanoid" id="A0A194XAJ6"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="389"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="612"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1175" mass="131749" checksum="EF725DEEC51481B3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAK9</accession>
    <name>A0A194XAK9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_685108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071534.1">
        <property type="nucleotide sequence ID" value="XM_018215021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAK9"/>
    <dbReference type="GeneID" id="28824747"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685108"/>
    <dbReference type="InParanoid" id="A0A194XAK9"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="152"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="31961" checksum="59265F40A8F27095" modified="2016-10-05" version="1">MAQSTPAPVPELKTYNGNCHCGAFKFSVQMPDIKSVVECNCSICFRKGYKWAFPGEGPFTIERGGGDLKEYEFGVKSMVHKFCGVCGIGIGGSRHAAPPGQQLGINVRTLQDVDLWALEVNKYDGCAIAPAYEAPKYKGPEPTAEIENAKTYTGSCHCGAVTMALKTKEPLSGGSEHIQECNCSICARNGTILTYPASDQVHIENKGSLTSYVFGRGFQSHEFCGICGVSVYIKKLDVSDEAWEKESGKGRSKEVWKGICPVNLRCFDCVEWDAIQVKKGYYKDVGREYVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAX3</accession>
    <name>A0A194XAX3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_67212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071262.1">
        <property type="nucleotide sequence ID" value="XM_018213259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAX3"/>
    <dbReference type="STRING" id="149040.A0A194XAX3"/>
    <dbReference type="GeneID" id="28822985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_67212"/>
    <dbReference type="InParanoid" id="A0A194XAX3"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
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        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="27212" checksum="057DC246BD0DE5F2" modified="2016-10-05" version="1">MASKKGAYENTASDTDFRKKYDRAEYAQKAKDREAKEKEESKLRYEAKLAGKKYYAPLTGEETLTQARASRLDVSQNVGKVMLMPAGAATGKKGRGAGFYCEACDLTFKDNLQWVEHENSMQHLRAIGQTGEVKKASAEDVRERIERIWERMQEEKKDDVKTLGERLEIRKEEEEKDREERRRKRKELVERQRAEKEKEVKIKKEYGEDVRVEGEHDEDDMMASMGITGFGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC81</accession>
    <name>A0A194XC81_MOLSC</name>
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        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_584224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018209256.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XC81"/>
    <dbReference type="GeneID" id="28818982"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584224"/>
    <dbReference type="InParanoid" id="A0A194XC81"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
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        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="247" mass="26457" checksum="CD6EDC554BE53ECD" modified="2016-10-05" version="1">MKFTQVALPVLFSTAIAAPTKTIKERSTEICGQYDSLVTRTYTVYQDLWGEDNASSGSQCTTIDSETDGTVVWSTSWTWAGGSSDVKSYANVALTTTGVELSAISSIPGVWKWSYTGTSLVADVSWDMFTSSTATGSNEFEIMVWLAALGGAGPISSTGSAIATMTINDVSFELYSGPNGDTTVYSFVAVDEATDFSGDLLDFFNYLVDNEGFSTSQFITTLEAGTEPFTGICVSFCPSHNYINYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCA9</accession>
    <name>A0A194XCA9_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071742.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCA9"/>
    <dbReference type="GeneID" id="28832222"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781601"/>
    <dbReference type="InParanoid" id="A0A194XCA9"/>
    <dbReference type="OrthoDB" id="3565130at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="649" mass="71889" checksum="E328AEE0F9B5D52A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCF7</accession>
    <name>A0A194XCF7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684764</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCF7"/>
    <dbReference type="STRING" id="149040.A0A194XCF7"/>
    <dbReference type="GeneID" id="28824668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684764"/>
    <dbReference type="InParanoid" id="A0A194XCF7"/>
    <dbReference type="OrthoDB" id="3547906at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="110" mass="12543" checksum="90E30A752219843D" modified="2016-10-05" version="1">MSVLLIALICHEFGGNRYSSPLLSFCAMLSVKLYTKTWKEPGNYNSCLSSVIWVVQLIIFHTSACLEKAELGEILGWRLLLFIVSKEVVLTYRDVDLHIDHVPRLLLSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEN3</accession>
    <name>A0A194XEN3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_774505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072988.1">
        <property type="nucleotide sequence ID" value="XM_018221970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEN3"/>
    <dbReference type="GeneID" id="28831696"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_774505"/>
    <dbReference type="InParanoid" id="A0A194XEN3"/>
    <dbReference type="OrthoDB" id="3563007at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="898" mass="102275" checksum="3D255F78F77A5AB3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF05</accession>
    <name>A0A194XF05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferas-like protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_667811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ18748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073103.1">
        <property type="nucleotide sequence ID" value="XM_018213002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF05"/>
    <dbReference type="STRING" id="149040.A0A194XF05"/>
    <dbReference type="GeneID" id="28822728"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667811"/>
    <dbReference type="InParanoid" id="A0A194XF05"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="244" mass="26660" checksum="6D8B90F178087CCD" modified="2016-10-05" version="1">MAQQQHRPGHHDPEFTTNPLWAAVNEYTMSHLHPSSRPNGAVLDSTLESIKSNGTPSGSTGTVQSKFLELQCRILKIKHVLEIGTLGGYTSIRIATENPRCHVTSIEVSEKHAAVARENITKAGVADRVEVLVGPALEILPTLLADIEAGKRERFGLTYIDADKLNSVNYFDFGVKMGYSGGLVVVDNMVSRGNLVVEDKRDHEHVKGGRLVVETVGKDTRVDAVVMQTVAKKNYDGFLFAAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFQ2</accession>
    <name>A0A194XFQ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_499920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072957.1">
        <property type="nucleotide sequence ID" value="XM_018207956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFQ2"/>
    <dbReference type="GeneID" id="28817682"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_499920"/>
    <dbReference type="InParanoid" id="A0A194XFQ2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="164" mass="18036" checksum="8DBAF40BB8632BAE" modified="2016-10-05" version="1">MQSTDQKMRVSSGLPYRLPLSTARAVKMLWNMAKMIKDAGICNPHLSVENSTGFKALVPSLSFHNCSSQATKLRVCLAIFINSASVAGNACQNLLHNTTIFFLAYPPADSFCSNAFGLCNLILKIAESQISHLLCREASRKSVGLVVCPVYVFVTYYRLNNHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG07</accession>
    <name>A0A194XG07_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073431.1">
        <property type="nucleotide sequence ID" value="XM_018219576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG07"/>
    <dbReference type="GeneID" id="28829302"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731498"/>
    <dbReference type="InParanoid" id="A0A194XG07"/>
    <dbReference type="OrthoDB" id="5245631at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="352" mass="39883" checksum="BA056F78F110DC11" modified="2016-10-05" version="1">MVKARPHQHELLDEDEDEELNDENSIIVDVPPPRSKSRKRTVSDLSGEVKVKTPSPKKRKVLPVRGKDGDEEKLPSTRPVVEIPARTMSPPRATTGTIEGHESGRKTNHRRFDSEEPVEEVFSTTREPAGNAEDSQSEEHEDEDSDDDAPEAVGMQEAAQTIRAREKDAAKAVKEQAAASRQKRKEREETLRKQAESTKKRKPKTEVERLEDRVIITIESDDDEDEKVRADIEAIDDEDDVAPPTRISRHRDVPDLLPLEFLEDDDPNEVIAAEEAPRIAPRKKKFKELLEKGPKDRRVGKTTYRVTKTQSTNLAPKAAHNARSVKESWLQGRSGMKIDSNRKPFSKGFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGQ7</accession>
    <name>A0A194XGQ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_773675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073708.1">
        <property type="nucleotide sequence ID" value="XM_018221945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGQ7"/>
    <dbReference type="GeneID" id="28831671"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773675"/>
    <dbReference type="InParanoid" id="A0A194XGQ7"/>
    <dbReference type="OrthoDB" id="3555020at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="235" mass="27664" checksum="2C649CB9C902C1CF" modified="2016-10-05" version="1">MNDLPSPSTPRNLRKRPQKRTVPEDDDDDSTDNEPSAKKKRQWKRDWVRWVSESKWEKDPSYKQKVGSEEIHGSDAMKFYNLTGEEMDTLPFWKFENINSLSHPGRSYVDNEVKRLAYRKLAMLVGFHKEDMEENELLRQGYILFEEKQIQRRQGNPNTPTEPITGTIFIPKPHETYRNPLTGIPHGCWESPVWRNGVLIGHWLNAQFTPDDDGEWIPKERFKPLGSDTWIEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGV4</accession>
    <name>A0A194XGV4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_559581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073758.1">
        <property type="nucleotide sequence ID" value="XM_018208438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGV4"/>
    <dbReference type="STRING" id="149040.A0A194XGV4"/>
    <dbReference type="GeneID" id="28818164"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_559581"/>
    <dbReference type="InParanoid" id="A0A194XGV4"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="27238" checksum="6D0CB0D2CA794864" modified="2016-10-05" version="1" fragment="single">YFTSTRMLNYQLQHCKSTRSKTEIPFLVLTPLDVPQYQVDQLAEEGATIIPISLIKVPSWIKPGAHRWQNVMSKLRLFELTEYSRILFLDADTFILKPMDGIFSDPASFPLNTSQQVIQEDNEAPLPPTYLFASLPEVLHTMHPYPPHAWRNFNAGFFLFSPSLALFNYYLSLLNITNRFDPTYPEQNLLNYAHREFGNMPWRRLGGRHGEWNINLPNMNDVRKGVRSVHAKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGV7</accession>
    <name>A0A194XGV7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_731765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073719.1">
        <property type="nucleotide sequence ID" value="XM_018219612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGV7"/>
    <dbReference type="GeneID" id="28829338"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731765"/>
    <dbReference type="InParanoid" id="A0A194XGV7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="27618" checksum="14D85060ED8EA5F9" modified="2016-10-05" version="1">MCVTWLHVHHCGHSEKHEHNCYPSLLQRECYEEYVCKNLHTGISCWMCARRLRRQVLRLKDPSEQEEVRVSLDSNMEEHARLEAVVKKWREAAAGTLSNSDQPSETREDGNQRWTYSNRAFTSSPEWKDAVAKVVADEIGSDEDEEFENEESDDDEFAVKKPDTPLKQLENSTAIIKKMPGVMKSIEDNTATIKDMQDVKKLVADNTTAIKELSGAVKGWLEEEAREEAQTAHVMKKPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHK6</accession>
    <name>A0A194XHK6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 alkane hydroxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_611457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074050.1">
        <property type="nucleotide sequence ID" value="XM_018210581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHK6"/>
    <dbReference type="STRING" id="149040.A0A194XHK6"/>
    <dbReference type="GeneID" id="28820307"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_611457"/>
    <dbReference type="InParanoid" id="A0A194XHK6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268255" evidence="9">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="486" mass="55495" checksum="6DFE1990F6EAB734" modified="2016-10-05" version="1" fragment="single">MFLAVLYWLINDILYRIAAKKAGCSIPIKYFHWDPFLALDLFYQRLSDMRAGDSVATDRNLLKKYGKTVQTNAWGIKQYVISDPVNIQTILATQVDKFGNEPMNRKMCGDFLGDGVMTVDGHLWKKSRQMINPVFARAQVSELSSFEKQLSRMMEKIPKDGGTIDMQPLCKQLFLDSSTEFVFGKSANSLSPETDSPIARRLPGIFDEALVSMFTRYMMGKFSFMAGSKKKFLAQCKEVHDIIDGFIDEEIELQKFGTNIDSAGPYSYVLLKEMVRTTDDRRAIRNELMNVFFPAHDSSAIFLSNIIFLLARYPNKWDKLRAEVLGIGKQKLTFELLKSMKYMQAVMNETLRLHSPAGGSWKTCLAPCILPHGGGASGKEPILLQAGDQVRMSFAPLHVDPDIWGKDAEEFKPERWENLKQSWNYIPFMGGRRICPAQQNVLTDVACIMVRLMQRFKGLENRNECYEYVDRIAFTRESRNDVKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHL6</accession>
    <name>A0A194XHL6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_611468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074060.1">
        <property type="nucleotide sequence ID" value="XM_018210582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHL6"/>
    <dbReference type="GeneID" id="28820308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_611468"/>
    <dbReference type="InParanoid" id="A0A194XHL6"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="617" mass="67214" checksum="A84942D0082AB546" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIL3</accession>
    <name>A0A194XIL3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_705802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074326.1">
        <property type="nucleotide sequence ID" value="XM_018217479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIL3"/>
    <dbReference type="STRING" id="149040.A0A194XIL3"/>
    <dbReference type="GeneID" id="28827205"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705802"/>
    <dbReference type="InParanoid" id="A0A194XIL3"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122879" checksum="7B5810A8A990A234" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJE3</accession>
    <name>A0A194XJE3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_682009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074596.1">
        <property type="nucleotide sequence ID" value="XM_018214418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJE3"/>
    <dbReference type="GeneID" id="28824144"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682009"/>
    <dbReference type="InParanoid" id="A0A194XJE3"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="53"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41609" checksum="75E5398ABA1E4EBA" modified="2016-10-05" version="1">MTNTDAQAILNYLAELEFPKIMETSLQFALFKTYGIPTISGLLVATKEFSTPENASKRYADTTVLISEFTSHHPKSERVIKAIARMNYIHSMYQKSGKISNEDLLYTLSVFVTEPITWVEKYEWRPFTEMEICAVGTFWKSIGDAMGIQYKGQLARSEWVDGLEFVEDIQNWAESYEVRYMVPAPSNKTTADELVPLLLFYVPRRFKPAASHIVGVLMGDRLRAAMSFPTPPRAYFNLAHVMFESRRYCLRYLSLPRPTFMRARELADKPDKTGRYHLGKYLAHPYYNKPGLLNRWGPEAWFVWYMGGDVPGSNGNQYIPEGYTFEEVGPRPMKNKGSEETKAWEEKIKAERPAGCPFAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJR6</accession>
    <name>A0A194XJR6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_666851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074377.1">
        <property type="nucleotide sequence ID" value="XM_018212940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJR6"/>
    <dbReference type="FunCoup" id="A0A194XJR6">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJR6"/>
    <dbReference type="GeneID" id="28822666"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666851"/>
    <dbReference type="InParanoid" id="A0A194XJR6"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="734"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1098" mass="122990" checksum="BA76557310E533AB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKA0</accession>
    <name>A0A194XKA0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_716637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074572.1">
        <property type="nucleotide sequence ID" value="XM_018218281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKA0"/>
    <dbReference type="FunCoup" id="A0A194XKA0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKA0"/>
    <dbReference type="GeneID" id="28828007"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716637"/>
    <dbReference type="InParanoid" id="A0A194XKA0"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="317" mass="35004" checksum="462DA61D882A3D84" modified="2016-10-05" version="1">MKKIAWLPAGLRGNLQWTQCPRAIISNTFPRGPGFQAPKNQFSTSNHLQASIAAPEVRFKNQGSEGDELEGGAVFNARLVPNSASYFTAQPIFTDDLLKLQNILKRYANLPVLKPGDAPRVAWRSLADYRNLVGETVKAAKYSKIVEVLHRLNHIHPSLMPQEVQEALNEYKRDVNPYQNQAKLGHVNTLGKALGVGRRKSSSARAWVVDGTGEVLVNGKTLTEAFGRIHDRESAIWALKCTNRVDKYNVWALVSGGGTTGQAEALTLAVGKALLAHEPALKPALRRAGCMTRDPKRVERKKPGHVKARKMPAWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKC9</accession>
    <name>A0A194XKC9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_550176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074919.1">
        <property type="nucleotide sequence ID" value="XM_018208293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKC9"/>
    <dbReference type="STRING" id="149040.A0A194XKC9"/>
    <dbReference type="GeneID" id="28818019"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_550176"/>
    <dbReference type="InParanoid" id="A0A194XKC9"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="34519" checksum="375D432A35CDF7B5" modified="2016-10-05" version="1" fragment="single">HLYGIRKPKNAPIEVSSSTSLAFTSTLSSLLPSKNKEDIFSSHNRNTKKRAARDLEDEERGRQDIGGVDEDVLHRSKRKMEQKAKLYSRMKRGDYVAAEGEADGLVDFDRKWVEGGKEEESEVESDDGQGEMVDYEDEYGRARRGTRAEAERMERRKMNKVLGAEELDRMSARPAMPKTGLIYGDTVQSMAFNPEESVVQKMEEIARKRDRSMTPPEMKHYEADKEIRSKGVGFYSFSKDEGLRGKEMEALEKERLETERVRKEREAKKEKRRLEIEERRKAIGEKRARKQADSFLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKY6</accession>
    <name>A0A194XKY6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_453958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075114.1">
        <property type="nucleotide sequence ID" value="XM_018207628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKY6"/>
    <dbReference type="GeneID" id="28817354"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_453958"/>
    <dbReference type="InParanoid" id="A0A194XKY6"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="19818" checksum="9BB73CF253991547" modified="2016-10-05" version="1">MSADAAPTPLSKVDSAVQGLSSSPPKEEKAAKRRQSSVAAAGVFNIKDLEEEGTKLEIAKETQKLNWRINKSPMSLEEPEKSALKKMLTTPPIKKIDLHFPLGLEVTARNLKGVTIKDALDAIYKQYRKKADDELETPVLAGFEWDPEESWTRLIVHCKKEGAPQPKKKAKKGEAAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL68</accession>
    <name>A0A194XL68_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_694643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075335.1">
        <property type="nucleotide sequence ID" value="XM_018216717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL68"/>
    <dbReference type="FunCoup" id="A0A194XL68">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL68"/>
    <dbReference type="GeneID" id="28826443"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694643"/>
    <dbReference type="InParanoid" id="A0A194XL68"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="303" mass="33109" checksum="6120A25E43FB7979" modified="2016-10-05" version="1">MSRANHLSGDPAAINEFIDKFDIFLLDCDGVLWSGDHLFPGTVETLELLRSKGKKVVFVTNNSTKSRSDYQKKLTSMGIPSNVEEIFASAYSSAIYISRILKVPPPKNKVFVIGEIGIETELKSEGIEFIGATDPAFRRDITPEDYKGIADGSLLDDNVGIVLAGLDFHITYLKYAHAYQYLARGAKFLATNTDSTLPANHTFFPGAGSISIPLINMTGQQPTALGKPSQAMMDSIEGKFQFDRKKACMVGDRLDTDIRFGIEGKLGGTLAVLTGVAKKEHWEGEDAKVVPAYYVDKLSDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMM4</accession>
    <name>A0A194XMM4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_609947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075736.1">
        <property type="nucleotide sequence ID" value="XM_018210537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMM4"/>
    <dbReference type="STRING" id="149040.A0A194XMM4"/>
    <dbReference type="GeneID" id="28820263"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_609947"/>
    <dbReference type="InParanoid" id="A0A194XMM4"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="240" mass="26819" checksum="54F5EEBF859DB084" modified="2016-10-05" version="1">MAIPVAITKGGRERVPQASALFAEAFATDPVITYILHNMPESKRLTYLPKYFNALLTAAALNDATFIEIDDFKSCVTMMHPGKKVDNPWTLIPAGLVQMLFDIGFGPCWRMLFEFSPMTDRCKLKGLRGQKKYFYVFFTATASSAQGQGLCTKLLNHWQDIASREKVPMWLEATTEKSMKIYAKCGFEVVERMTLGKGKVEPKGLKPVKEGGSVKGKEELEGVPIWAMVWWPEGSKPVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMM7</accession>
    <name>A0A194XMM7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_547989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075768.1">
        <property type="nucleotide sequence ID" value="XM_018208267.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMM7"/>
    <dbReference type="GeneID" id="28817993"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_547989"/>
    <dbReference type="InParanoid" id="A0A194XMM7"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="270" mass="29908" checksum="9F4EDA1A181359F5" modified="2016-10-05" version="1" fragment="single">ARTPVYFLGIGGPNSMVNTEHPSYSQIISIGHEIATQVKPRAVVVFSAHWQDGPSKVSINVAEQADIIYDFYGFPKHYYEYKFPNKGSPEIAEKVIEKLTGAGIEVERVERGLDHGVWAGFIVAFDPKKNPLNVPIVQVSLFASEDTDQHYRMGQALESLRDEGILIIGAGMAVHNLHDFRASRGTGQTMPYTFSFDEALKEAAESKPEERRANMLESMKASDARKAHPTLEHILPMHVAAGAAGLDVGERLWTLPEGSLSWAQYRFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMQ1</accession>
    <name>A0A194XMQ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_577391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075788.1">
        <property type="nucleotide sequence ID" value="XM_018208887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMQ1"/>
    <dbReference type="GeneID" id="28818613"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577391"/>
    <dbReference type="InParanoid" id="A0A194XMQ1"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="607" mass="67117" checksum="54DDE4216FDC3FF0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMQ9</accession>
    <name>A0A194XMQ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_433118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075771.1">
        <property type="nucleotide sequence ID" value="XM_018207493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMQ9"/>
    <dbReference type="GeneID" id="28817219"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_433118"/>
    <dbReference type="InParanoid" id="A0A194XMQ9"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="170" mass="19013" checksum="8B9940518D01559C" modified="2016-10-05" version="1">MTLFRLIPSRGVSSDGRRAEPRHEESKSRCILCRSEVGITVPQQEQATTRAILVANPSSCFGPGTRMRNHPYLDASSCSQCCREPSPNLLADRSWSLCHATRDLVSPEMRTSARISDQAAPKVDHVSTLHDDYCRPFWNIMRVDLSKQNRRRSQPMPLSSSSAAVSATRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN10</accession>
    <name>A0A194XN10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_715431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018218205.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XN10"/>
    <dbReference type="GeneID" id="28827931"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715431"/>
    <dbReference type="InParanoid" id="A0A194XN10"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="436" mass="45848" checksum="B02D29A731B2D89C" modified="2016-10-05" version="1">MASFANACRLSARLTARQLRQDAAARGFRSSAKVMAAQNFTMPALSPTMTEGNIAKWNVKEGDSFSAGDVLLEIETDKASMDVEAQDDGIMAKITQGDGTKGIQVGSRIAVIAESGDDLSTLEIPAEEKEAAPSPKKEASTPKSESSSESQTEATPTPSSSASSEASAKPAGKPKKQTYPLLPSVGHLMKEHGIEESAIEKMSPSGPNGRLLKGDVLAYLGSISSSYPAELSSKIEKLTHLDLSNIKVAASAPAPAPKPKPAESIPEPVIPQESEIAVPISMQAVLDVQKRIQSTLGVFMPLSTFIARATDVANDNLPRSKTQAATADELFNQVLGLDTVTTSAGVRGTFLPQITALPSADPSAPVKPAKQLDIIDILSRKTRSTSSGLASKPLPGLSNSVNVFSVKVPKGDEKRAQVFLDRVKSVLEAEPGRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNL5</accession>
    <name>A0A194XNL5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trichothecene C-8 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_639303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075677.1">
        <property type="nucleotide sequence ID" value="XM_018211612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNL5"/>
    <dbReference type="GeneID" id="28821338"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_639303"/>
    <dbReference type="InParanoid" id="A0A194XNL5"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
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    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ21322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="514" mass="58196" checksum="C11FA4034DAD7461" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNR8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNR8"/>
    <dbReference type="FunCoup" id="A0A194XNR8">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNR8"/>
    <dbReference type="GeneID" id="28818592"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577036"/>
    <dbReference type="InParanoid" id="A0A194XNR8"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="NCBIfam" id="TIGR01197">
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        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="144"/>
        </location>
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            <end position="185"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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            <end position="26"/>
        </location>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21818.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="601" mass="63507" checksum="00C8B18FFBCF67EC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPI1</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268473" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="144" mass="16256" checksum="79E04700AB220FCE" modified="2016-10-05" version="1">MHTLTHTILSLLLFCLTTTNACMHYKATFPFNPTLPFEASISDNRITTCWISTTYAEHRALQIAVKAQKSEEAGFLPWEFECLRLGIEGYKAHANVGARTVTYIAHGQEFYFIPKEKEDVVGEKWVYDLKLWCGKPGKGGLIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPT8</accession>
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            <fullName evidence="5">CHY-type domain-containing protein</fullName>
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            <taxon>Leotiomycetes</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UCP017292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF1">
        <property type="entry name" value="HELPER OF TIM PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12943" checksum="1925B0B1E80A501A" modified="2016-10-05" version="1">MSTSTTHGTPAVHGLDVSDKTQCAHWHSAKDIIAIKHKCCGMYYACISCHEAIAEHENQVWPKKEQETTKAVLCGNCRRELNITEYLRCDNICPNCKATFNPGCRNHYHLYFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPU1</accession>
    <name>A0A194XPU1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_393247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076429.1">
        <property type="nucleotide sequence ID" value="XM_018207206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPU1"/>
    <dbReference type="GeneID" id="28816932"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_393247"/>
    <dbReference type="InParanoid" id="A0A194XPU1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="84" mass="9801" checksum="1AAF144B9786D506" modified="2016-10-05" version="1">MSYPTKMIKNNKSKENVKSIERERQHRLKRTSRDSVERERTEKMICQRKKNTASATASTIRNSKENASSEPRIHTHTHTLAASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRA7</accession>
    <name>A0A194XRA7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">LY89DRAFT_636901</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077041.1">
        <property type="nucleotide sequence ID" value="XM_018211507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRA7"/>
    <dbReference type="FunCoup" id="A0A194XRA7">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XRA7"/>
    <dbReference type="GeneID" id="28821233"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636901"/>
    <dbReference type="InParanoid" id="A0A194XRA7"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="371"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="238"/>
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        <location>
            <position position="319"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
            <position position="322"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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            <dbReference type="PROSITE" id="PS50206"/>
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        <source>
            <dbReference type="EMBL" id="KUJ22686.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="478" mass="51594" checksum="99997909D5D2D089" modified="2016-10-05" version="1">MDSATKTAERLRIQIAATEEQLKNLKGQLADLEAQSLGNSFQNVSVQEELDPVTHEKWPLAAEDYKRYGRQMIVPNIGIQGQLRLKNASVLIVGAGGLGCPAAAYIAGAGVGTIGIVDGDEVETSNLHRQILHSTSKVGMKKVDSAILYLKSLNPNLKYNAHTSHLTPENSQGIVSQYDLVLDCTDHPTSRYLISDICVLLQKPLVSASALRTDGQLIVLNSPPLLAGNEAGGPCYRCVFPKPPPAESVVSCGDGGILGPVVGVMGVLQALEATKLIASGKLTSSGSEEAKKDASMLLFSTNSNPPFRSVRLRSRRPKCFACSAEAGLTLEGLSSGSLDYVLFCGINVPVSILGRDERIEAKEYAKLKTENRTDHLLVDVREKVQFDICSIEGSVNVPFSSFQGSRFKEGDGKQPTWIPQSLPPDAPIYVVCRLGNDSQVVTKRLKESGLNKNGRYIGDIKGGLKSWKEQVDSSWPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRQ5</accession>
    <name>A0A194XRQ5_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_311590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077186.1">
        <property type="nucleotide sequence ID" value="XM_018206638.1"/>
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    <dbReference type="GeneID" id="28816364"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_311590"/>
    <dbReference type="InParanoid" id="A0A194XRQ5"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="term" value="P:signal transduction"/>
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        <property type="entry name" value="PX_domain"/>
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        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
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        <property type="entry name" value="Phox-like domain"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
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        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
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        <property type="entry name" value="RHOGAP"/>
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    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="902"/>
            <end position="1017"/>
        </location>
    </feature>
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            <begin position="1465"/>
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        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="60"/>
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        </location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1531"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1545" mass="168487" checksum="4FB71CFAA5DF03D0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRT3</accession>
    <name>A0A194XRT3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_637035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KUJ22759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211513.1"/>
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    <dbReference type="STRING" id="149040.A0A194XRT3"/>
    <dbReference type="GeneID" id="28821239"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637035"/>
    <dbReference type="InParanoid" id="A0A194XRT3"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="222"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="626"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="756"/>
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        </location>
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            <begin position="156"/>
            <end position="355"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113253" checksum="FD7EDFB750490765" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUE3</accession>
    <name>A0A194XUE3_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_179098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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    <dbReference type="KEGG" id="psco:LY89DRAFT_179098"/>
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    <dbReference type="OrthoDB" id="4932428at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20478" checksum="15911CFDED8CE333" modified="2016-10-05" version="1">MDLHFCWEIHVTRNHQNIGDIIQSLNTHRVNTLTELCRIERIAASGSEDDQLAFQEPMTSAWSYYVNSNQMLNELRNLTRDYPFSSDVLDDAKWRVSNDPASNRTWNYAWLVLIKMKDDEMIEAYAASEAAKPEMWAGRTPDDEEAQQLAACFAYAWNSALEQMLRHWDTAPSRTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUH0</accession>
    <name>A0A194XUH0_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_703231</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POA1 family.</text>
    </comment>
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    <dbReference type="EMBL" id="KQ947404">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217307.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28827033"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703231"/>
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    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="7">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="19376" checksum="D5644D3CC52A200C" modified="2016-10-05" version="1">MAKRALQALSLTKHSGDIFDAPDHTVLIHACNTQGKWGAGIAIPFKDAYPDAFNTYHEHCLSDPVQTGTCLLIEPCGPSKHWIACLFTSAKHGRGKDKPDEILENTRRAVEDLLEKVKEAEGKGEMVGSLRMCKINSGKFGVEWERTEMVLKEVEVKEGHRGVVEVWDREGDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV43</accession>
    <name>A0A194XV43_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_11481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078433.1">
        <property type="nucleotide sequence ID" value="XM_018205101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV43"/>
    <dbReference type="GeneID" id="28814827"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_11481"/>
    <dbReference type="InParanoid" id="A0A194XV43"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="24376" checksum="04EEEC179B31B3D2" modified="2016-10-05" version="1">MMTIPSYRYSIRPVSIGDYGPQYLALLHVGAHHSLHIVYDCSTRRTLGRRTRTRMTAGIRTAKIDRWYCSRGWAVEAKRQRQRRSKLVDQDRRRKKGKRARSAHGQTDIRLVCVGSYSHSPHTSHLTPHTSHLTHTRTPSSMTPVAAPSRIAPPLTLHPREWIKIKRGQAKDPRWTPRPLSNDSLHVVQSRTGLSSLQQPCHYWAKEVDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVD0</accession>
    <name>A0A194XVD0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_557875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078451.1">
        <property type="nucleotide sequence ID" value="XM_018208405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVD0"/>
    <dbReference type="FunCoup" id="A0A194XVD0">
        <property type="interactions" value="1401"/>
    </dbReference>
    <dbReference type="GeneID" id="28818131"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_557875"/>
    <dbReference type="InParanoid" id="A0A194XVD0"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="180"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="487" mass="55765" checksum="E0CCECE79840D770" modified="2016-10-05" version="1" fragment="single">SYAGNEHWSALLEDITDLKIDLDSLDTSEMTDFKPQILFGRTHASRSEIISSLPPRPVCDILITRWYKTMDMASLILHTPTFMKEASKLHNPNKTPLMWFGLLFSVLGLASHFYAVSGEELPTLPEPFTSTSQMSVFYRDRCAQCLVEVNYLRPRRYTVETLCFYFALEKFQGKDSEFGDYVVLGIIIKVAMRLGYHRDASHYPNISSFEGEMRRRKWSLIYQLDLVTSAQVGLPRTIREEETDTLEPKNLLDTDIEEGMATLPHPRPSTDVTPVAYAIFMVRLLRQLGRIVDQINSTTPPPYEKVMSLDSQLIETHATLPPYLTMKSLSHSIIDGSDLILRRYSLEVCFQKSRCVLHRKYLIPGKSILKFRYSRTTSVDAAMRLLNIQRSFHDSIQPGGRFSGEQWRNSALINQDYVLAAMILCLDLSWDMRLGGGIRSNFGDEIEKMWPRNERLQALESSYAIWLKSSEMSALAVKAAETLRIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVJ0</accession>
    <name>A0A194XVJ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_13540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078506.1">
        <property type="nucleotide sequence ID" value="XM_018205269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVJ0"/>
    <dbReference type="GeneID" id="28814995"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_13540"/>
    <dbReference type="InParanoid" id="A0A194XVJ0"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268699" evidence="1">
        <location>
            <begin position="20"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="94"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="271"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="49834" checksum="F0A2E16BC392AF97" modified="2016-10-05" version="1">MKSVLSLTSLLALAAAVVAADDDDACENEVEIRQDTTLKTSTSTFAANVTNVFAPVTAPHVDTQDIANIVPQSNVSLYYASNITTSAGLVVNHTMALPAVLLEEIASISSVDCTPSSVAVTFNDSSFFAAAESVWTSNGTFVMITNHLGDCDPELERSFFVVDSLSFDNTTLVATASSLKSNVSSTAAKTQISFGAVPGVALAKRDLTIDPSFTISPSLALTPDTVLYSYSPYVTVTADTASFTSNVTLSGYLEYNWFLFKMEKLYIDIDAGFTADLAISAEVTSAYSTTFTYAPTALFYGLTVPGVLELGPQLQFSVDAEISASEAVTITSEVTLALADGNVHVDLLDESNAGTSGWTPTYTASANISGEVDAALNPTAALTVEIAINFFGGLLDLSTGLTAKPGFNNSFILTAAKGVDLSGVQNLTTSGTCAEGLELASNFPFSVEAFVTEFYSTELYSVDLPILADCFSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWI1</accession>
    <name>A0A194XWI1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_713401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078943.1">
        <property type="nucleotide sequence ID" value="XM_018218047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWI1"/>
    <dbReference type="GeneID" id="28827773"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713401"/>
    <dbReference type="InParanoid" id="A0A194XWI1"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="342" mass="38974" checksum="4FFAD5D93F4A3EE1" modified="2016-10-05" version="1">MEVHVLDNYYLAITLLITIGYQLFFFSIAFSLKFDKLTDFAGGTNFVVLAIITLAFSGHHNARQIVCSLFIMVWGARLSAFLLFRILKTGKDDRFDDKRDKFFPFLGFWVFQMIWVWTVSLPVTVLNSPNVTQYPQPAFGTGRDIAGVILYAIGMIMESVSDVQKYLFKARQSDKSAICDKGFFSWTRHPNYFGEIIIQFGIYMIAVSPAANGYVKGQAYKALYATILGPFFLTILLMFVSGLTLQERPGAKKRYEKNNHWEEYSRYLNRTSILIPFPPQLYEKMPTILKRTIFLEFPIYVFDPAKHSDAGKGQSGAEEGNAHKPSTSTDNRQSGDRLVNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX59</accession>
    <name>A0A194XX59_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_713469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079029.1">
        <property type="nucleotide sequence ID" value="XM_018218056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX59"/>
    <dbReference type="GeneID" id="28827782"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713469"/>
    <dbReference type="InParanoid" id="A0A194XX59"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="289" mass="30958" checksum="FFF37887261D991D" modified="2016-10-05" version="1">MTFLETSAVTAEFRRRQRERRERGGLRNRRHQRRGDDDEAKDAGDTKASSDDDDSPSQDESSKSSSQTRTSTSSLTSLSKSSQSLASASTTTSTLSQVTTTPVSKTSVALTSLRTSTSLQTTPLPVVTTPSATALPASTRSRQSSSTLSSEIATSQTTGPGISSKQSPNEAGSNKETVTILAVTGAIVGILALLALIFYIRRKFKRPKIREEEREARAYAARSIWGNSSTTSNALSHTTMEQFVPPITMGRSQNANSNGAGNDAVDRRECGPIFLVTESCIWAVAWGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B253</accession>
    <name>A0A132B253_MOLSC</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_692455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060833.1">
        <property type="nucleotide sequence ID" value="XM_018216540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B253"/>
    <dbReference type="GeneID" id="28826266"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692455"/>
    <dbReference type="InParanoid" id="A0A132B253"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="310"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="598"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="930" mass="106489" checksum="24CEE8F20C9A535F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2K6</accession>
    <name>A0A132B2K6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_769184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060916.1">
        <property type="nucleotide sequence ID" value="XM_018221810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2K6"/>
    <dbReference type="FunCoup" id="A0A132B2K6">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="GeneID" id="28831536"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769184"/>
    <dbReference type="InParanoid" id="A0A132B2K6"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF532">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="542" mass="58955" checksum="9D494EFEE14F5067" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2Y0</accession>
    <name>A0A132B2Y0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_602986</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060958.1">
        <property type="nucleotide sequence ID" value="XM_018210276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2Y0"/>
    <dbReference type="STRING" id="149040.A0A132B2Y0"/>
    <dbReference type="GeneID" id="28820002"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_602986"/>
    <dbReference type="InParanoid" id="A0A132B2Y0"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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    <sequence length="1217" mass="135388" checksum="7844B466D8446439" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 120377</strain>
        </source>
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    <accession>A0A132B590</accession>
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="219" mass="24941" checksum="94C8911A55C6E089" modified="2016-05-11" version="1">MPLGIITSIAACPAIIGTTEAVQQGKKQNSREKHRSRKANLLVTCHDPSRKARDIHGGTVVLRNNKLYCTNVNPKSKYLPDEGYDNEASQGHLFAGYFFPYPESSWGRRGEGYVSTIMDDPPQLNWIYVDKDTYEVKYGLKKDTIGHHVGPWNVTPIDRRLNLDGWEGFTVVEEEEGVWALYFDWDDDGLDGKVGLDKRIMEVELSRKEIRMMKGDCIM</sequence>
</entry>
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    <accession>A0A132B5D0</accession>
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        <lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
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    <dbReference type="GeneID" id="28823471"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678456"/>
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    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="4">
        <location>
            <begin position="297"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="533" mass="59964" checksum="FAB0A3506E750B0D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5W9</accession>
    <name>A0A132B5W9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_765866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062161.1">
        <property type="nucleotide sequence ID" value="XM_018221691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5W9"/>
    <dbReference type="STRING" id="149040.A0A132B5W9"/>
    <dbReference type="GeneID" id="28831417"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765866"/>
    <dbReference type="InParanoid" id="A0A132B5W9"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="485" mass="55649" checksum="6873810956C782FF" modified="2016-05-11" version="1">MEAHEGTIAIIEASVRSFSERQQPFRIYHGSTNSTRDSQRRLDKAVDTSKLNHVLSINKEDKMASVEPNVPMDALLQATLEHGLVPLVVMEFPGITAGGGFSSTSGESSSFRYGFFDGTVNWIEIVLANGTVTRASRTEKPDLFWGAASSFGTLGVVTLLEVRLREATNRDSKPDGRLSGRYRLRSGRLTSSLPAGASVHQFTRRSDPWFYIHVQRRCATAGNSVVKEYVPLVDYLFRYDRCGFWVGRYAFRYFITPFNRITRFLLDRFMHTRVMYHALHASGQSRMYIIQDVAVPYNAALEFQEWLDDTFNMYPLWLCPLRQRRDGGNPEARHGLYASLADPEASSEFMMNFGVWGPGSKNRIEFVRQNRLLEQKVDELGGQKWLYAHAYYTQDEFWSIYDRKAYDALRAKYGASYLPSVYEKVKVDVDAEERAIRASWVAWLLWLFWSIWPLSGLYGVYKAFRGGEYLLQKESSSLIRTLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6C4</accession>
    <name>A0A132B6C4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Reducing type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_354188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062246.1">
        <property type="nucleotide sequence ID" value="XM_018206953.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B6C4"/>
    <dbReference type="GeneID" id="28816679"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_354188"/>
    <dbReference type="InParanoid" id="A0A132B6C4"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
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    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_AT"/>
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    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
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        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GroES-like"/>
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        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
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    </dbReference>
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        <property type="entry name" value="PKS_MFAS_DH"/>
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    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="37"/>
            <end position="463"/>
        </location>
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            <begin position="1047"/>
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        <location>
            <begin position="2583"/>
            <end position="2657"/>
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        </location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2666" mass="294742" checksum="78D39207D06EC4E3" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6M2</accession>
    <name>A0A132B6M2_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_349096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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            <end position="39"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="344"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="42164" checksum="C41DB3BAC2EA96D4" modified="2016-05-11" version="1">MAQPTSKFCGIPSRYRLYLASSPILCVADALSALIRLITLSIRLPIKPRQAFQLVVHARSDPINSEDKKPPESQTWPRYLFFILGTLPAAIKLSSFSGTPWTQVWGLMFATSFIVTELITLLGHPHPHPSSSDQPTSTSTVEAILALSTLQWETSTHAPIRTKTHSLFQTLSKLETTLFLTALLTHLGLQIWTIHTLWQPASRVLETAPLARGIVTWVTFAISLYLMLTSLAWLVASCFGLQGHVARFWTLAWKAEIAAALLPHPPSQNHGSGSGTGSTIPPPPGWVHRAGSAMAIWAYLVGMIWCGYWVLERVVGRWEAVGRVLLLDARGEEEERGVRVDENAYLCFWVFLGGLGSCGLWYAFLYEEVGTVNPSWTDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B756</accession>
    <name>A0A132B756_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_691133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B756"/>
    <dbReference type="GeneID" id="28825964"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691133"/>
    <dbReference type="InParanoid" id="A0A132B756"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="32607" checksum="729E13417F49DED8" modified="2016-05-11" version="1">MSEFSPFPRLPPELRNKIWGHVANQEPRALDLWTDFKRCEIANTIFYTQAYECELSHRPPPPIFRVNSESRKEALKHYTLEFATGMTLPKGISVTVSARIYINYSVDILLPRGYWNLVAFSNLASRAGGRLKHLAVDVNGSLWKDNLRDYCKKRCWVFYELQELILYDSSGVDMFKRSDFLEKFRERYRGGPKDLSFTDWVEDPTAQMVGVKNIFEKMFDRIEGKVEEEVEKPKGEGRVLTEADIHPSYLKDCEPTHADDLQRPVVRLARLEVTEPTVVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B795</accession>
    <name>A0A132B795_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_789525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062224.1">
        <property type="nucleotide sequence ID" value="XM_018223265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B795"/>
    <dbReference type="GeneID" id="28832991"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789525"/>
    <dbReference type="InParanoid" id="A0A132B795"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="36549" checksum="25793D865D3B8664" modified="2016-05-11" version="1">MDSETVPRAQYRQLGQSGLKVSLPILGGMGMGDKSNGVSEEIFGKAIREYNIPRHKLIILTKCYNPARESNTPELLALNKKELEVHPDYVNQFGLSRQGIFNSVNASLRRLQLDYIDLLQIHRYDPETPIEETMKALHDLVQMGKVRYIGASSMWAYQFAMMQFCAEKHGWTKFISMQNNYSLLYREEEREMNKFCDETGVGLIPWGPLNTGRLARPSRDQTTARAKNQKVTTHDAAIIDRVEEIAGKKDCKMSQVALAWINERVASPISSFSSVARMDEALAANQIVLTEDEEKYLEELYEPRPIKGHSNWKGRLAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7D1</accession>
    <name>A0A132B7D1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_711984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062254.1">
        <property type="nucleotide sequence ID" value="XM_018217944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7D1"/>
    <dbReference type="GeneID" id="28827670"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711984"/>
    <dbReference type="InParanoid" id="A0A132B7D1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="91"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="380" mass="42598" checksum="827BC1A6910DE7DB" modified="2016-05-11" version="1">MAPSATEVLPIDSRIKDYVVQKKDTLALPAAARARLEKAGINLSNGYPERPAKPLYLDDAIEIRNVDREHVDAGARADKSKSALFSAAKEVIDLTKHIGTEIVGLQLKDLTDQQRDELALLIAERSVVFFRDQDLTPQEQKKLGEHFGEVEIHPQVPHVPGVPGVTIIWPALQATERKASFRQPGGASKWHTDLVHEKHPAGITHLHNDTIPSIGGDTLWASGYAAYSKLSPEFRKIIDGRKAVYVSAHTYLDRNDPTAGPKRIERIHPIVRVHPATGWKSLFVNRAMTKEIVGLDKAESDLILNYLYDVYEQNVDIQVRFKWTPRTSALWDNRITIHNASWDYEGSEPRHGTRVTSLAEKPYFDTDAPTRREALGLPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8J8</accession>
    <name>A0A132B8J8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_325056</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063080.1">
        <property type="nucleotide sequence ID" value="XM_018206736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28816462"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_325056"/>
    <dbReference type="InParanoid" id="A0A132B8J8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1178"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1202"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1296"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="427"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="639"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="972"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1376"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="373"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="908"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ08725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1661" mass="183877" checksum="2FDE34A09E137B06" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAG5</accession>
    <name>A0A132BAG5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_286113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063747.1">
        <property type="nucleotide sequence ID" value="XM_018206485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAG5"/>
    <dbReference type="STRING" id="149040.A0A132BAG5"/>
    <dbReference type="GeneID" id="28816211"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_286113"/>
    <dbReference type="InParanoid" id="A0A132BAG5"/>
    <dbReference type="OrthoDB" id="3600056at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288027" evidence="6">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="494" mass="51248" checksum="BFB5D6FE592E5961" modified="2016-05-11" version="1">MFLWSTLFVLLQCNSVRGTRQIQKRQITATPPTTCTPSSATTTINSQADAKALSTCFVIAGSVLVSTAVNGTISFDGPQNITGNLIADSADLLTGLSSSSLSNISGDIIITNLSNTFDVFNFPSLGSAGSLTLSSLPGLGSVETLQGFTTKSMTISNTSLGSAPLLSNDTEILDINNNFRIGDLAFNLASISTSLNFDSNGAATFSFPKLVWASNITAINVPQLNLPVLAVVNNSFGIYGSLEVGLNAPQLTTIGTFENAVGTGSLSVVSSPELTTLGLGSLRLIGGNLSVIGNNALRSIALTALQTVGGGMDLEGGFHSANFSSLVSVKKAMSIQTTDSSFDCSTYKALDFTVIQGGFECRTINSSMSTAPAPVVDSPSPGISPGAKAGFGIAIPLIAVLSAGATFFWLRHKKRNRMTVTVAPRLGYSIGAELPGGGKNEEKGLPVQVNELGEYYFKPVPEAHELCGGETVEEGRGGGEMRVERVQESGSSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAR8</accession>
    <name>A0A132BAR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_629224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063112.1">
        <property type="nucleotide sequence ID" value="XM_018211199.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BAR8"/>
    <dbReference type="GeneID" id="28820925"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_629224"/>
    <dbReference type="InParanoid" id="A0A132BAR8"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="6"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="931"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2417"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="931"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="963"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ08757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2504" mass="273633" checksum="6B9DB6689098CAB3" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBF2</accession>
    <name>A0A132BBF2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064105.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBF2"/>
    <dbReference type="GeneID" id="28825770"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690164"/>
    <dbReference type="InParanoid" id="A0A132BBF2"/>
    <dbReference type="OrthoDB" id="3545468at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288052" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="21660" checksum="EDF28F41B0525ADB" modified="2016-05-11" version="1">MASTLLFLLSSLLSIGRALPNVTAIQIDAGTCQAFPNSFHGAGDNADAFVFHPDQADNLALNGLTTGIYGTNLVAYPNSATDPPTPTIFCCDRGGTILDGFGVQSLLLPTNRTNDEELGYLESGSKPETYTLEVNGTALDGVYLGKGNVTTWGFRKGSGDMKDLWLVRLLAPSPTMRRRGEDGGVVLYDGEVKGFLKVVGWVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBK2</accession>
    <name>A0A132BBK2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_711310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063382.1">
        <property type="nucleotide sequence ID" value="XM_018217894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBK2"/>
    <dbReference type="GeneID" id="28827620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_711310"/>
    <dbReference type="InParanoid" id="A0A132BBK2"/>
    <dbReference type="OrthoDB" id="3562932at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1260" mass="135259" checksum="C70D81914202A95F" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC76</accession>
    <name>A0A132BC76_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_760748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064326.1">
        <property type="nucleotide sequence ID" value="XM_018221516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC76"/>
    <dbReference type="STRING" id="149040.A0A132BC76"/>
    <dbReference type="GeneID" id="28831242"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760748"/>
    <dbReference type="InParanoid" id="A0A132BC76"/>
    <dbReference type="OrthoDB" id="3504677at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288125" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="25758" checksum="6328F56A1880CEF5" modified="2016-05-11" version="1">MILSIVALSSLGRMVTADCTRNVLVAAADLYVAAQTAGQLGDLQKLLTTDYKYQENNKASDVKSSVLGTALKIDHRKTTADTIACASYTELVATTSKPYVIGTQLRHTADGANVTLIDTIAATTGSLSFNAAKTLGYIQKEDWSVIDASKRDSRTVLQNAADAYLDMWTNASAYNAVPWGTPCERVEGSSLNSPYTVGAPKGGSTQRNSMRRYVIDDTLGSCDFRLENGKLRFVHTITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCN5</accession>
    <name>A0A132BCN5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_787903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063969.1">
        <property type="nucleotide sequence ID" value="XM_018223116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCN5"/>
    <dbReference type="FunCoup" id="A0A132BCN5">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCN5"/>
    <dbReference type="GeneID" id="28832842"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_787903"/>
    <dbReference type="InParanoid" id="A0A132BCN5"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
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    </dbReference>
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        <location>
            <begin position="82"/>
            <end position="545"/>
        </location>
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        <location>
            <position position="137"/>
        </location>
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        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ09614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="564" mass="62086" checksum="61BFCF3D036337C6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDB8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_760184</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="320" mass="35933" checksum="D91EBD4316A7C5D6" modified="2016-05-11" version="1">MAVEHVVFRALIRRGRSSVQLNFILITILRYATRARRAFTSIRDVTARYYNPAKSADMGTTGLGTRRNTKKFRQKYLDKKAEAAASAQATSSPKGSSSKITGLPDRTGSSKIPSGEASPVKLIEEVNSLAARRRKWQNSELSFAAKPVTKSTELNREVYVDSNFFKLQIDSKIQLFKYSIIVEDHVTPINVEGVRRVKKETKSFLTREYLTNNRFVNVPAHKKWALDYDLVIISVGPLYTRSGRDLARAMMLSSNLGGQPPRNGRVAPPPLSVRVEDLGPLDMGHLVKHVTKKEFAADLNDELKALDIICWKRSTRKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDX3</accession>
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        <submittedName>
            <fullName evidence="4">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_628203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_628203"/>
    <dbReference type="InParanoid" id="A0A132BDX3"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0005763">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ09867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="11027" checksum="39DCFB6A942C27E5" modified="2016-05-11" version="1">MVVKIRLARFGRRKAPFYNIVVAQARTARNSKPIEVLGTYDPIPKAPTDGEGKPFKDVKLDSARAKYWLGVGAQPSDPAWRLLSMAGLLEPKYRPTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WS04</accession>
    <name>A0A194WS04_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_739746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065108.1">
        <property type="nucleotide sequence ID" value="XM_018220498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WS04"/>
    <dbReference type="GeneID" id="28830224"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739746"/>
    <dbReference type="InParanoid" id="A0A194WS04"/>
    <dbReference type="OrthoDB" id="4835952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267395" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="72" mass="7330" checksum="A8D35BC50CFF1F4F" modified="2016-10-05" version="1">MQFSVIALLSLVAVAFASPIALPDRLDDIVARQTTATSSGVDAEAPAMSDADGNVVSFNTASVYLDATAKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSH9</accession>
    <name>A0A194WSH9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_739897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065271.1">
        <property type="nucleotide sequence ID" value="XM_018220525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSH9"/>
    <dbReference type="STRING" id="149040.A0A194WSH9"/>
    <dbReference type="GeneID" id="28830251"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739897"/>
    <dbReference type="InParanoid" id="A0A194WSH9"/>
    <dbReference type="OrthoDB" id="5390271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26903" checksum="23154620BC72D5F7" modified="2016-10-05" version="1">MACLAAAYHALYRLDEAEKLKLEVLKARKKIQGDKHPATLMAVANLAATYVRQERLNTAVDLVVPLVAARKEVLGERHRDTLTTLLILTNIYIKKSMWDEAEDACIQVIEGRVSVLPLNHPHTIWSKAHLALIYHHQGRLNEASAVCEDVILAQEEVRGSEHEETLLSIHNLALVRKSQGQAELAFQLMTRARDSRRKTLGQCHYRTLESDRALQRWQLSATGEATQERNSRYAGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTC1</accession>
    <name>A0A194WTC1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_239475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065558.1">
        <property type="nucleotide sequence ID" value="XM_018206096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTC1"/>
    <dbReference type="GeneID" id="28815822"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_239475"/>
    <dbReference type="InParanoid" id="A0A194WTC1"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267423" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="20131" checksum="E9309A47B9835A1B" modified="2016-10-05" version="1">MQLSLTFLTAFASLAMAQNPFLYNPGDLTSITAGSSFMIKWAPSTGTTDTVTILLRQGNPAQLTTVETIASSITNTGAYLWPVPASLVNGALYTFEIYDDLNHDLANYSNQFSIVSTNTVTSVLAAPASTITTNGHVTTVYATATAAAVVGSSSVSGSGSGTTTSPVESPVATKNAGSRREVGGVVMGVVVGVLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTW2</accession>
    <name>A0A194WTW2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative inorganic phosphate transporter C8E4.01c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_237335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065479.1">
        <property type="nucleotide sequence ID" value="XM_018206073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTW2"/>
    <dbReference type="GeneID" id="28815799"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_237335"/>
    <dbReference type="InParanoid" id="A0A194WTW2"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="112"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ11124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="669" mass="75485" checksum="52B32903573733C6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWR9</accession>
    <name>A0A194WWR9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_709976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066484.1">
        <property type="nucleotide sequence ID" value="XM_018217794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWR9"/>
    <dbReference type="STRING" id="149040.A0A194WWR9"/>
    <dbReference type="GeneID" id="28827520"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_709976"/>
    <dbReference type="InParanoid" id="A0A194WWR9"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="247"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ12129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="312" mass="34680" checksum="284E8938D6AD019D" modified="2016-10-05" version="1">MAPSDLAQLLEMGFEQERAELAVKKTGGLQGAMDWLETNQDKPIEELRAPAANDDETNPSIEPAALKEGEVAKSLVCDDCGKRFRSEAQASFHGDKTGHENYSESTEEIAPLTEEEKKQRLEELREKMKEKKAKQAIIDKEEQKRNEKIRMKSTKEVQDAKEELAKNEQIKAAAKKRQEKLDDMAAKKRIQDKIAADKEARRLKAETEKANREGRQAPIQAEVPDAPVVSTGPRKEATEARLRLQTNGGTVMKTFPVDTTLFEVGQALETENGGPVESFTMTFPRKVFSGSVDFGKTLKEAGLVPSAVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WX97</accession>
    <name>A0A194WX97_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative PKS-NRPS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_209836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066905.1">
        <property type="nucleotide sequence ID" value="XM_018205860.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WX97"/>
    <dbReference type="GeneID" id="28815586"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_209836"/>
    <dbReference type="InParanoid" id="A0A194WX97"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="22"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="961"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2417"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3543"/>
            <end position="3622"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="961"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1115"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2498"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2507"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="3976" mass="438036" checksum="D736B9B4B03976DC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXU1</accession>
    <name>A0A194WXU1_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_193282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067148.1">
        <property type="nucleotide sequence ID" value="XM_018205722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXU1"/>
    <dbReference type="GeneID" id="28815448"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_193282"/>
    <dbReference type="InParanoid" id="A0A194WXU1"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="234" mass="25039" checksum="7EC635A93BE18BA5" modified="2016-10-05" version="1">MPFLKKSEVAEDVRSFDAPPTEEHPAMRGSNKSNIVDSINLGLTVLALLSAMTIVGTSAETLQVYNTTRLGNGHFLSMWPNEFDIRPTVALVVCGSIMIVAAALGVVVKKVPAIANHTLLATPLSLLFPSISLVAALIATSFFYGVNTSSSTFSLQSWTCQWSDIDMDVKPHWGTLCKESKVALYLSVMMIPLQVLVLGTVVVGFLGRVRGWVAGKGKGNGGMEEERKGSPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXW0</accession>
    <name>A0A194WXW0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_785388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067166.1">
        <property type="nucleotide sequence ID" value="XM_018222891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXW0"/>
    <dbReference type="GeneID" id="28832617"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785388"/>
    <dbReference type="InParanoid" id="A0A194WXW0"/>
    <dbReference type="OrthoDB" id="3798994at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267678" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="278" mass="28674" checksum="0C4AB68F2EB8C27C" modified="2016-10-05" version="1">MELRRRRKVLVVLLSFWQSLAGAANTTSEVANLGIAAQACLATGFWDCSCIMLDFQCGCECSRFSSDVRACIVNSCSPVQQNQALNLFSSTCATATIITTSISTKLSSTSSVSSKTTSSISQMTTTSKGTILSSSNSKASASQTITQSKATASIASNTNTSPTSMGSGTTGLSVKTYRLSSTSTGTSENGGVFPILISSSDTGPTTAGTQSTWGPYRGNTSAMGTATACWQVSASGTARTTCAIQANPFQASAGSLEPGRVLVPMIWGIGVFVFLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYC0</accession>
    <name>A0A194WYC0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_673070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067321.1">
        <property type="nucleotide sequence ID" value="XM_018213331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYC0"/>
    <dbReference type="GeneID" id="28823057"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673070"/>
    <dbReference type="InParanoid" id="A0A194WYC0"/>
    <dbReference type="OrthoDB" id="3561182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="632" mass="72106" checksum="A293B39C32A8F0B5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZI6</accession>
    <name>A0A194WZI6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_592498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067479.1">
        <property type="nucleotide sequence ID" value="XM_018209702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZI6"/>
    <dbReference type="FunCoup" id="A0A194WZI6">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WZI6"/>
    <dbReference type="GeneID" id="28819428"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_592498"/>
    <dbReference type="InParanoid" id="A0A194WZI6"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="19450" checksum="217D56E8679EDAD4" modified="2016-10-05" version="1">MSSSVRLLVCSIGNPGSYLNTLHSAGHSVLSVVASALSYPPFQKSRAFGNGLVSAGSKFTLWQSTSLMNVSGAGVASAWRQFQKESRGESIRLVVVHDELELGLGQVKVKSGSASAKGHNGLKSINGLLKGSDYTRIGVGIGRPESRDSDAVASYVLRKMNGAEKSKIEGSAGKVVEELRRLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X048</accession>
    <name>A0A194X048_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_785055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067684.1">
        <property type="nucleotide sequence ID" value="XM_018222851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X048"/>
    <dbReference type="STRING" id="149040.A0A194X048"/>
    <dbReference type="GeneID" id="28832577"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785055"/>
    <dbReference type="InParanoid" id="A0A194X048"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLL-like beta propeller" evidence="1">
        <location>
            <begin position="100"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="195" mass="21236" checksum="45A1F58C7AC26726" modified="2016-10-05" version="1">MFLTPLSAFLPYPFAGGTATRISGGVFTSPINSISYAPNTLDLFGLGTNSAAYHKSYNNVAVWSGWNSLGGIFTSNLVASTWGDNEIDVFGRGTDNAMWWNHWNGVFTSEPSSVSWGPGRIDVFGIGTDGAMYHKYYDSGVWSTTWENLGGVLLSAPTPVSWGPDRLDIFTIGTDDAVWHKYWTGSAWGGWERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0D0</accession>
    <name>A0A194X0D0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068011.1">
        <property type="nucleotide sequence ID" value="XM_018215417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0D0"/>
    <dbReference type="STRING" id="149040.A0A194X0D0"/>
    <dbReference type="GeneID" id="28825143"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687062"/>
    <dbReference type="InParanoid" id="A0A194X0D0"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="25664" checksum="59430CF9BE3B8ABC" modified="2016-10-05" version="1">MQPSRVSSEAPEVVPGQFLTTNSESLSNLSPSTYQASTHLSGHSRAHSWLSSISDRKSKQPDSSSTLVPQIIQDDAAPYQPKVHSRRVFGLVTTIILVAITFCLGGGIGGGVASAVLSGQKSKSTSTSSSSPAQATTIIDASGCPLINNSTYTSQTGSTFLTVCSTSILSSDSGQIIDFSNSIQSSFDSCLNACAVATGCVGASWYMFDPQMPSRNMGCWLKNGTGEEVVASGGLSVVSGYLKSALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1C1</accession>
    <name>A0A194X1C1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_151648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068346.1">
        <property type="nucleotide sequence ID" value="XM_018205399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1C1"/>
    <dbReference type="GeneID" id="28815125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_151648"/>
    <dbReference type="InParanoid" id="A0A194X1C1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="160" mass="18617" checksum="7FF3039B646DD104" modified="2016-10-05" version="1">MLQRRQWHSMEFAHHNQRLDAKPWSGSMDMEWRARNLTCEEAWLLPISLCDDCSFRLDPDTEEVLISETDTRPAPHLMSFPSAAPRSTNISLLYTTEKHHCEKRETTHEILQTTSNCFEQPFEPSHAVAVATNLNESHRACYHGFFAPGHIVWKDAYDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1Z6</accession>
    <name>A0A194X1Z6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_132648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068571.1">
        <property type="nucleotide sequence ID" value="XM_018205249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1Z6"/>
    <dbReference type="GeneID" id="28814975"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_132648"/>
    <dbReference type="InParanoid" id="A0A194X1Z6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267784" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12949" checksum="25F94E596943D485" modified="2016-10-05" version="1">MAMRGWKWSGGKLCLILPLLLDQRPFGITDYYYYFTERAGLARWETRGSLVGQKRNIHGCCITSNSRLTGTRLSPQNPEKHMAAACRVQRLCTVIADTRAAAPATVLDSQNTVCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X275</accession>
    <name>A0A194X275_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_708689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068628.1">
        <property type="nucleotide sequence ID" value="XM_018217699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X275"/>
    <dbReference type="STRING" id="149040.A0A194X275"/>
    <dbReference type="GeneID" id="28827425"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708689"/>
    <dbReference type="InParanoid" id="A0A194X275"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267735" evidence="3">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="75"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ14273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="40118" checksum="432668E085BA24B4" modified="2016-10-05" version="1">MAICRFVSFAACISYVLGACSSIEVRKEWRSFTTDEQTAWIDAVKCMAELPHNSSLVATVGEFAAIAKITSNSSYYDDYTYVHSDLNPTIHFTGLFFPFHRYFVWSYTQALKNDCGYTGVAPYWNWTIDAANVKDSTIWSDDASSGLGQPVGIASNDFVVGTGGFSSNFTLAYPTTHGLRRNFTLVPYSADAGSSFFPDPDIDANATFTPAKINALIANYTGDFKGFQKYMEGFEGPHGSVHEILGGDLAGYCPEDANEACFDDEPSPTFSANEPMFWMHHAMVDRVWWLWQNHHPNNTYAFEGGSVQNFTDYDQFPNGGPPWLSMDSILPTDGILMPAETTLEDIWITEGDLLCYTYDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3E4</accession>
    <name>A0A194X3E4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_736580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068904.1">
        <property type="nucleotide sequence ID" value="XM_018220145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3E4"/>
    <dbReference type="FunCoup" id="A0A194X3E4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="28829871"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736580"/>
    <dbReference type="InParanoid" id="A0A194X3E4"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47134" checksum="3AD16C3E167F21E0" modified="2016-10-05" version="1">MARRDDSPPSTESSGASISSFTPLEESVPHSPSRTRHLPFRIPKWRRQAHSEGPFLNEKRRIHIRQLIKSAILILLLTSLAIVTWLALILTVANRLRIPHLNNGLQKILETYHAPNSTHAAYPTWVEDFSRGVKPVSCHSHNDYWHRIPLYEGLAVGCVGTEADIWIGNHGNGTVDLFVGHNQKSLTQSRTLRTLYLDPLYDILSNQNTLSSSLPNVTNATGTQDAVSGSPTGVFSTSPSTSLILALDMKTDGHATWDTVIAQLDTLRVQDWLTYWTPSQGVVQRPITIVGTGNTPFDLVISNSSYRNIFFDAPLTSLSDPNTPYNSNNSYYASSSIKAAIGTVSFGKLSGGQRDKVTAQVDKANQLDLRSRYWDTVSWPVGWRNRVWEQLEDLEVGILNVDDLAAGARWDWEMCVVGGVNICNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3L1</accession>
    <name>A0A194X3L1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_736451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068767.1">
        <property type="nucleotide sequence ID" value="XM_018220120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3L1"/>
    <dbReference type="GeneID" id="28829846"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736451"/>
    <dbReference type="InParanoid" id="A0A194X3L1"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29353" checksum="701D51619888980A" modified="2016-10-05" version="1">MSRLEKLPAELRHQIFSYCVVSPTGYLEPIDLRGLRCPKDTSLSGTYSFYLACNTPLDRDSMYKWSITGLDNPRLRNKISTSLLRTNKQIHAEASSIFWNSNTIFFFDIEEMVEFETKAGSVPFRNIVTMCVGLNERAESLEWQQIEGILQQLSKSRSTSDATSKSSLKKLELAISKRMINFISKWSLSENINHANKGMIKDAIIAWYLLKTLERGKELGSGIERCVVLGKEQVCEPLEAVDLDKMVELWRQAWGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4B1</accession>
    <name>A0A194X4B1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_128046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069373.1">
        <property type="nucleotide sequence ID" value="XM_018205213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4B1"/>
    <dbReference type="STRING" id="149040.A0A194X4B1"/>
    <dbReference type="GeneID" id="28814939"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_128046"/>
    <dbReference type="InParanoid" id="A0A194X4B1"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ15018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="363" mass="41003" checksum="96CCB6833F67BD46" modified="2016-10-05" version="1">MNSDITLTALMHHSQTRRKACEQCVRGKRRCDLLVPRCSRCAKRRVDCEYAGVKDVLEPLQSAPFCGPARSTRSTNLTIEPLSKTFELQELLFPLNSIDSPVRVAHTPLQFNYLTTYFRISIRSLALQSRTFFIHPSFLRNLIPTPLESAISVCALSTLNSPSTFDVLDSYLKTLITSSPATFYSPSTILFSVQALIIFQTIRLLSSDERRLLHAEANFPLLNTWTIALQTAYFSLPSDSTSYKDWVLKESVRRTILTSVLLRSMYGTLRDGYTDLVPLLASLPVSSNGKFWELERNESRWEGVRKEEVSTYWEFVGAWISESASNGKSEKGEFERVLLCLEEDGKVGEAGRELISNVKFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4G1</accession>
    <name>A0A194X4G1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_736001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069299.1">
        <property type="nucleotide sequence ID" value="XM_018220073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4G1"/>
    <dbReference type="STRING" id="149040.A0A194X4G1"/>
    <dbReference type="GeneID" id="28829799"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736001"/>
    <dbReference type="InParanoid" id="A0A194X4G1"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ14944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="39326" checksum="A8DCD62090060CB6" modified="2016-10-05" version="1">METRSRARQEPDAISDTPMALDVPLERIAPTLTQNTPQSAIPQPNMGWHMDPNDLPLEHPIEFMRQLESIGWNGGEHFFPGKHDEFCFVCGGSMELFGCQTCETCYHAACMSPTLEVDDVPTFWFCPHCVDRELHIPPDLSTSYLTPMSPPQPGGVYPSPSQSSLGQASTPNSQPNAPAPLSKRKPEGQMIDIKGSKQKIHEIARSLNNATLTETRKEPKADLTKAPSGRSRRTNSPPRKRSKYSAYSSEVDKALAVIHKELEAAAQNGKSEGSLRERIHTLEQELRLKDGQILLSSRELEVARQQGDTARLQAEVKELRAQNEGLKTLVEKKDAELRDWRSKLKTLLGNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4H4</accession>
    <name>A0A194X4H4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_784001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069314.1">
        <property type="nucleotide sequence ID" value="XM_018222743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4H4"/>
    <dbReference type="GeneID" id="28832469"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784001"/>
    <dbReference type="InParanoid" id="A0A194X4H4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="44435" checksum="DD3DC68E6187EECC" modified="2016-10-05" version="1">MAKNRSANISRKGKKAAQAARKNAKATVVETPVKTVDASSEAELTQSEASFCEAVMNEAESATTTELDNIESGNASKSSTEQVTLNKEFNFDFAENKADTYPIIDPTFATEVFEVLSPASPVAEPASALPTAEFTFSVPRVIADLKARVKKAAGMDNIEKDCAPIIEAPKELEIREKLPEADLELAKKDIDQAKRDVQLSEMQTQIDELQNNMNEWHTGHVQTRNEIEVMIASMSACLKKVTDLRQRLRSVEGDTLGLVNIVKDLQTQITVVKAVLAGIPHLHQELHELKEEVATMKEGSAAMKEDAAAALKKAHAEIAALQKTYVEAAAMKQAKAQVEQMVNTLTAASVPLPKSEKKTIRIVLDKALNKLEKLPTIGPVGSRKGEADTPRVPGIHKAGRAGSGGGFCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X520</accession>
    <name>A0A194X520_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1168-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_540735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069630.1">
        <property type="nucleotide sequence ID" value="XM_018208165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X520"/>
    <dbReference type="STRING" id="149040.A0A194X520"/>
    <dbReference type="GeneID" id="28817891"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_540735"/>
    <dbReference type="InParanoid" id="A0A194X520"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="101" mass="10963" checksum="3B05A569450BEBE4" modified="2016-10-05" version="1" fragment="single">MSEPIPESIPTSADPRSKRPTKKRALSPRSQTASQISSLMSKPDTVINLPSTSITTHPGSAPPEIVQNVQGSSAGAGSGEFHVYKASRRREYERLRGMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5C9</accession>
    <name>A0A194X5C9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_783447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    <sequence length="516" mass="57019" checksum="CE3F9667548EB799" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Labutti K."/>
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                <person name="Grigoriev I.V."/>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </feature>
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        <location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="211" mass="23695" checksum="92A889FDE17530A7" modified="2016-10-05" version="1" fragment="single">PHKTRSGIPPPARRSMEDESRELPPGWVRQYDSKSHHQFFVDTASSPPRSIWHHPYDDETYLSTISASERERIRNLHPVPTRADIEAESSGDDEHHHYEGGGGEESLSGPKKFGRKVKDKLTGSTHQEREVARRKREEEERRMYEQHQHIRRQMSLAAETGQPQLLGKDRNGKDVYIEPPAADPYGGGFGGGGFGGYGGGLGYGYNPYSQG</sequence>
</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
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        <location>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="26"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="595" mass="65482" checksum="90F2FD0C588F0028" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7F3</accession>
    <name>A0A194X7F3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_103097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070446.1">
        <property type="nucleotide sequence ID" value="XM_018205023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7F3"/>
    <dbReference type="STRING" id="149040.A0A194X7F3"/>
    <dbReference type="GeneID" id="28814749"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_103097"/>
    <dbReference type="InParanoid" id="A0A194X7F3"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="47594" checksum="1013CC2CC07E1D34" modified="2016-10-05" version="1">MKVLLGATQLAKRSDVTEEHGRRDLRDNLESDFKKGDSPAEWAPGHPVAWGHEQWKFSSGEEKSVTSVSATSDEKYFAIAIDDTLVIFEVDGYKLASVLKTGDGPIKSIEFARKPSEDTYVLACQYGDQYGRATNVKIWLLDQDCREIDPDKKIVVEGYLPTFAPSVFSSDCKTLLLLATTTDEWGSHLAIVALDVQTGKEKFRMTGHTDSIMWTGFSPDDKFIASAAWDRYMKLWSGEDGKFIRDYGPTGAQNWACAFDPEGVNLAVTTGAHRALMWRIDDPQSFPIALAGKVGWERVISNSPDGTKLAIGSADGRLMVHETKAMTLIQVWQLGAEIGGSRWLKEVTEIKWLDNGNRISWTPSDGSLQMYDFETNMKWKWAAGKEDKWRRGAWFNTVVLLERKGLIGSRDQDGAFRMWKIPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7N0</accession>
    <name>A0A194X7N0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070533.1">
        <property type="nucleotide sequence ID" value="XM_018215043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7N0"/>
    <dbReference type="GeneID" id="28824769"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685216"/>
    <dbReference type="InParanoid" id="A0A194X7N0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23602" checksum="E7AF208F0992DB1F" modified="2016-10-05" version="1">MSGNDYYGGNQGQYPPQPNYGQQGQYPPQPNYSGNPPQHQAYPPQPNYGSPSPAPYGQQPPYGQQPPYGEQPQYGQQPSYGQQPPYGQGAQQPPYPSGQPNYGEDRSGPQGQLAPGEVGPNGERGLGATLVGGAAGGFAGHEFGGGALGTIIGGVVGAIGANALEHRHKKHKEEKKWEEQQGQYGAQAQYGGSQYGLAPQGHHHGHHRKHSRSRSRGLGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7R9</accession>
    <name>A0A194X7R9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endoglucanase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_618508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070212.1">
        <property type="nucleotide sequence ID" value="XM_018210841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7R9"/>
    <dbReference type="STRING" id="149040.A0A194X7R9"/>
    <dbReference type="GeneID" id="28820567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_618508"/>
    <dbReference type="InParanoid" id="A0A194X7R9"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267939" evidence="3">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="271" mass="29709" checksum="82E4EF4877DA6176" modified="2016-10-05" version="1">MLSLSHLSVVLALLHYSTCTPFHSVFSRATTALAASEHCGDEDYVILSGTPWIVYNMLYNADVTVGTQCTNFESVEKPATGNPEVIWSSVTDIEYVESTDNVPKGYSFVGLTQNLETTISAISSIPASYNWSRTNTTAFKGNICFDFMTSDTKGDSTSTSAQELMLWLQYEGSQLPIGWGDVVTTIDSLFGTSWKLYEAKNTDTGITVHSMLPDVQFDGSFEGDLKEWLEALVNLGRFTNETYVNVGNAGTEFFYGDSVMNATLGLQIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8D5</accession>
    <name>A0A194X8D5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_782684</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070780.1">
        <property type="nucleotide sequence ID" value="XM_018222605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8D5"/>
    <dbReference type="FunCoup" id="A0A194X8D5">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8D5"/>
    <dbReference type="GeneID" id="28832331"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782684"/>
    <dbReference type="InParanoid" id="A0A194X8D5"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.20:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="447"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="690"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="997"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ16425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117960" checksum="B2737749A6E84EE9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8H0</accession>
    <name>A0A194X8H0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_84129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070815.1">
        <property type="nucleotide sequence ID" value="XM_018223447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8H0"/>
    <dbReference type="FunCoup" id="A0A194X8H0">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8H0"/>
    <dbReference type="GeneID" id="28833173"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_84129"/>
    <dbReference type="InParanoid" id="A0A194X8H0"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="27936" checksum="FA2380D8086CF769" modified="2016-10-05" version="1">MEDKKFSEVQGGGSLILAWQIRNKRVLVVGGGEVAAGRILNVLNADAKVTVVSPREGLNPEVAYRIEKGQVDHLDRKFEPSDLDNVDMVLTAVDDPEASSQIWKLCKERKIAANIADVPPECDFYFGSVHRDGPLQVMVSTNGKGPRLANIVRRSIAENLPNNIGEAITKVGKLRQMLRKVAPGPEEGPKRMSWMIKVSDAYSLEDLCEMTDKDMETLLGFYGPDKVPRLGCLRAMEGEIDAFDGSFGFCVGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X973</accession>
    <name>A0A194X973_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_586081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070687.1">
        <property type="nucleotide sequence ID" value="XM_018209354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X973"/>
    <dbReference type="GeneID" id="28819080"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_586081"/>
    <dbReference type="InParanoid" id="A0A194X973"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="467" mass="50812" checksum="FF6E43732DD1EE24" modified="2016-10-05" version="1">MTGAEVRGIERVSETERKKSGGWDQIVFWFSVNLSFTSFASGMLGTEFYSLSFKTSVAIIMTMSLVGVATTAWITTLGPKYGLRTMALARFAGGWPGTFVFSVLNILTQLAYSVTVAIAGAQALHAVNEDVSLIAGIILISVVVMVLSVYGLNFVKIWERWAWILCFIIFMIIIGLGARGGYDVNKNNVTHDTGSDLIGDILSYAGIYYSISSGWTTIGADYNVDLPANTPPMRSAVLTFIGIYVPIVATAIMSCALLSITNPDYIAAFEKDSLGGLIGKILEPAGGFGKFLLVILMFSAVSCNIPNTYSGALSIQTLHPVFMKVPRVIYVILFTAVYLIAAIAGREHFGELLSDFASLLSYWTAFFTVIMLLEFLWFRRKSGHLGPINPDNFNDFSKLPPGYACCGAILVAIGGCVPAMAETWYTGPIALMVATPYGGDLGFEFSAVFTFVSYLVFRNLEIRYFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9W6</accession>
    <name>A0A194X9W6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_719259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070922.1">
        <property type="nucleotide sequence ID" value="XM_018218482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9W6"/>
    <dbReference type="GeneID" id="28828208"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_719259"/>
    <dbReference type="InParanoid" id="A0A194X9W6"/>
    <dbReference type="OrthoDB" id="3904217at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="16503" checksum="135B4668900898B2" modified="2016-10-05" version="1">MKQLIGVWKLLFITQPNNEPADTNLTGRIIFNDQGYMNALIRSGAAVPLPDSVDWDTATDAQIAAITRRIVAYSGQYEVRNESGQLFTHTTLDVSLDPSWMEEVQVRHAAFSNGTDGKSVLTLIPVENGKLADQSLVWEKLDLPTLTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAE5</accession>
    <name>A0A194XAE5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_585234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071491.1">
        <property type="nucleotide sequence ID" value="XM_018209313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAE5"/>
    <dbReference type="STRING" id="149040.A0A194XAE5"/>
    <dbReference type="GeneID" id="28819039"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585234"/>
    <dbReference type="InParanoid" id="A0A194XAE5"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="478" mass="54791" checksum="6E2F01A89690ADEF" modified="2016-10-05" version="1">MYTLTYHQVMPAFLDFIFPFGQQIYTRDFFFGGIRHENRLLDSDLGPDLPKLRRSGQEIRVCYSLKSVEKTDEPGEKHSPWSVRQTATYHSFDVETGSALWISVKGNDLIQDRVMTATENLGPDQRPFSTKERAFEEAMSIHLINCKWAGEQWRWYLNYLEEELQGGAGRRALSAKVVRERRPEEKEKLEFLRARSMSTKGTSKGRSGMTTFCQSPKPQPNRTRSASRESGAELDGHSQFSFDDSRDIQSLEDKTNEAIFVLNANIDVLGELKVYYHDLVVSQEHVKLFASNHNRVVERFGKQITSIINDLRMQITRAGALLRMLSDRKALVSLYGILNYRNAAASMTFAAKSQESANNMERMTRKMEELTVDMNELAQKTTQETVSMRIITLVTLFFLPGTFISTIMSTDIVRFQGPNGGPGPKTFQAEALKLYVYITLPMMLLTFAAWFLIYKLESRKADKKRRRKSLEKQTAENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAS4</accession>
    <name>A0A194XAS4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_49607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071618.1">
        <property type="nucleotide sequence ID" value="XM_018207926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAS4"/>
    <dbReference type="GeneID" id="28817652"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_49607"/>
    <dbReference type="InParanoid" id="A0A194XAS4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21558" checksum="CB00958099CE1D26" modified="2016-10-05" version="1">MFLEVKAIEGEVEQLKSQRTNLITILAGLFLLLWPIISSLPPFSPLPIAWILWPWQNQIDTARYRLREVNTVQRTVLSLELLTVELLDEKRHDVLCSVRQLEQAMRSTENLTPEQGLEAKSLKYQLEWLSAQIIIRLHKKAQEVEQANREREQAEHTERKVQSAFQGQALQEPEDDSSICPECTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAY7</accession>
    <name>A0A194XAY7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_684921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071272.1">
        <property type="nucleotide sequence ID" value="XM_018214986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAY7"/>
    <dbReference type="STRING" id="149040.A0A194XAY7"/>
    <dbReference type="GeneID" id="28824712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684921"/>
    <dbReference type="InParanoid" id="A0A194XAY7"/>
    <dbReference type="OrthoDB" id="3632757at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268022" evidence="1">
        <location>
            <begin position="26"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="200"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="454" mass="51452" checksum="84EBA83AAED47328" modified="2016-10-05" version="1">MIQSTGLKTLVAVLLSVGVAQSSAATREPQYVTLPSLREQLAITDAWRSERIANIPNILKKYDVDAWLISQHEHAEDTVFWSLKRATQFAARRRTLQLFLASPAPGLQSSYSWIDNTPEVWSNLLDVLEAQDARSIVVNVDAEIAFSGGMHAGELVEIQRRVGEKWQSRFVAEPMVGVEVVGTMPRGKEGDRLKWYKGLMETAWAMIGEAFSERVITPGFTTTEDVEWWLRDKVQAMNYTTWFQPDVSIIGKDDFGDPNPSPIQPKNVIHYGDLLHVDFGVTAIGMNTDTQHLAYVLYPGETEKDIPQGFRVGLKKANRLQDIVRENMKIGMTGNAILTKSLEQMKNEGFDGRVYCHPIGDWGHSAGTLIGMFNLQDEVPVLGDLPLLNHTYYSVELYAEHFVPELNKTLNFYLEEDVHWVDGDQWDWVWGRQENFHLIHSKAANQEGFFVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBI9</accession>
    <name>A0A194XBI9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rh-like protein/ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_55411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071890.1">
        <property type="nucleotide sequence ID" value="XM_018208342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBI9"/>
    <dbReference type="GeneID" id="28818068"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_55411"/>
    <dbReference type="InParanoid" id="A0A194XBI9"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="453" mass="48985" checksum="33D3B88707A2E463" modified="2016-10-05" version="1">MPAASVVLKAWEACDLTDTLFVLVCTVFCWPIIPAVGLAYSGYSHRRNGMSSFMPSIMVIATCSIQWFVIGYSFAYGEGSGVIGDFKYAFHNGVLADPVGTIPAILFSEFQLVFEATVCAIAVGGACERGRMLPLIPFIVLWSTFIYCPLAHMVWSETGFLGQLGVLDFAGGTPVHICSGATASALSIYLSYPLFRSKKSSTRTPSHIQLHRPGNSMSQLIALVIIWNAWLAFDAGTTLSLNFKSVMAMCVTNLCASGGALTWASMTYFETGKWSLDSTFMGAIAGLVMITPAAGFVDMPTAFFFGVFGAVICRQALRIKSTKFAKKMKWVDNGDTFATHCVGGIVGTVATGLFARKEVAFYDGATAIDGGVFFDGNVKQLGIQLLEALIGFMWSFIGSYILFALIDCVPGLEVLAKDEEIVSGMDAAEMEESFDGQWEDDYHPFVNGRLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC22</accession>
    <name>A0A194XC22_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_570040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071657.1">
        <property type="nucleotide sequence ID" value="XM_018208583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC22"/>
    <dbReference type="FunCoup" id="A0A194XC22">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="28818309"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_570040"/>
    <dbReference type="InParanoid" id="A0A194XC22"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="19227" checksum="AAA84AD50B271096" modified="2016-10-05" version="1" fragment="single">DPVFIAIDFEDPNSVAYGFDRNSDTQVGLSVLDSRNIHSASAKQSLGIKTFNFVTGSNQYFKTSARKDLWATSEHIPTTEMLQCIKKVIPRDRNIILVGHGFSHDVAALQSLGFDFYTSILGHFDTDVIARRLKFEDVSLGAVLKELGCPTLNLHNAGNDANFTLRALILLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCB5</accession>
    <name>A0A194XCB5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_733626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072159.1">
        <property type="nucleotide sequence ID" value="XM_018219825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCB5"/>
    <dbReference type="GeneID" id="28829551"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733626"/>
    <dbReference type="InParanoid" id="A0A194XCB5"/>
    <dbReference type="OrthoDB" id="3474594at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="102" mass="11526" checksum="62AF007B25A845E5" modified="2016-10-05" version="1">MSKAKLTWEAARKAYEELETAGDFKPPSGDIVAAAIAFSVMIAFEYRPRKKDEPFVPELFVKDMLGDCAATQIDALLDRKGWHHLDRDKLKRTAAMHVGDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCH6</accession>
    <name>A0A194XCH6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">LY89DRAFT_582902</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072233.1">
        <property type="nucleotide sequence ID" value="XM_018209188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCH6"/>
    <dbReference type="STRING" id="149040.A0A194XCH6"/>
    <dbReference type="GeneID" id="28818914"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_582902"/>
    <dbReference type="InParanoid" id="A0A194XCH6"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19943">
        <property type="entry name" value="NirB_Fer2_BFD-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011565">
        <property type="entry name" value="PRK14989.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="21">
        <location>
            <begin position="900"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KUJ17878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117798" checksum="88E0D2DE38661A0A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCT8</accession>
    <name>A0A194XCT8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_732669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072321.1">
        <property type="nucleotide sequence ID" value="XM_018219713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCT8"/>
    <dbReference type="STRING" id="149040.A0A194XCT8"/>
    <dbReference type="GeneID" id="28829439"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732669"/>
    <dbReference type="InParanoid" id="A0A194XCT8"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="293"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="676" mass="75835" checksum="34E47C1587F574BE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD11</accession>
    <name>A0A194XD11_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_58595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071997.1">
        <property type="nucleotide sequence ID" value="XM_018209349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD11"/>
    <dbReference type="STRING" id="149040.A0A194XD11"/>
    <dbReference type="GeneID" id="28819075"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_58595"/>
    <dbReference type="InParanoid" id="A0A194XD11"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="34300" checksum="397BB97DF28682AA" modified="2016-10-05" version="1">MATPAGNASASPPGTNINGNKRRGKKRIRSFTADERACHSAIEKQRREALNASFIDLARLIPALAPVHRLSKALIVQESIQYLKTQREMCLAAANEIQSMLAENMELVAEVNSWRKAYDVAGTGSQQVTPVGDAVRALLEFDRQVYGTFPAGFGDNGPAEEHVEEGAENNSRPRIEEHREVVQPKPPQNMAPVPDTGLSSQENVPAQPSFPIQQTLHPDPNELSEAIQIPDNFMILNQLPEQPSSLGQNIPPSFDTVYDLISTSDADMLQPDHFADLNLRHDIFHDFTIPLPEIGYDMAPAHDIPNFENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD51</accession>
    <name>A0A194XD51_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_697000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072037.1">
        <property type="nucleotide sequence ID" value="XM_018216872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD51"/>
    <dbReference type="FunCoup" id="A0A194XD51">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XD51"/>
    <dbReference type="GeneID" id="28826598"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697000"/>
    <dbReference type="InParanoid" id="A0A194XD51"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="49621" checksum="C13681E19B4D9DB4" modified="2016-10-05" version="1">MTLAAGPRFSRQATNAYASRPIDVTDFSWFTPKSPFWHAFAPKLHAAKPKCAPPKLSHKAVTGLAVAGSVYHPTNLLEMSDEDVLSMKRSHALFLDMLDYDTSHLSFTPGTQGIVTTAGGAYFPVLLTSLLLLRQTGSALPVEIFILDDSEYESLVCESVFPQLGATCILLSPFLASSNYKFVVEGYQIKILSILFSSFEHVLFLDADNFPVSDPEPLFSSSAYTSAGLVLWKDFWKPTFSPHFVNITSTEPSLENTIEAGQILVSRRERARTLMLAAYYNIWGEWYFDLITQGGPGEGDKDTFLPAARAVGEEVYVVGRGPEYLGARGNGAAVLQFDAVGDWACAKERVAPLFIHASWPPKLNALHNVRSERQWGSEEHALSLFGADMEKVAWGFMIEMACEGEFWDWGEGNKTSTGVCEQTRGCFRNMFGQEYIFKAGVRNESFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDF9</accession>
    <name>A0A194XDF9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_583060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072541.1">
        <property type="nucleotide sequence ID" value="XM_018209193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDF9"/>
    <dbReference type="STRING" id="149040.A0A194XDF9"/>
    <dbReference type="GeneID" id="28818919"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583060"/>
    <dbReference type="InParanoid" id="A0A194XDF9"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
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    </dbReference>
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        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ18186.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="915" mass="99572" checksum="07AD0E9984A57E94" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDV7</accession>
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        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28828108"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717934"/>
    <dbReference type="InParanoid" id="A0A194XDV7"/>
    <dbReference type="OrthoDB" id="10630784at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KUJ18370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="280" mass="30312" checksum="B39A7955F0EFC9A8" modified="2016-10-05" version="1">MGSEASSTCHGHRLFQLFREYLNLPEITTIDQICSGLVQVGLLVLISTTGRYFTWLGSYLGALGLNVNVPLYIQVRAESIAQAALPIVLGRPPLPVYQQPPPVLPAGGGVHTEMAMYRLRLCWYTALETATPVAAIAGLQVAMAMPLVAPAYPNVNAITFPLMGSAFVLGYTYDQAATQACKALYEYFHVTLGSESAPFGMLSSPVAAPGSIEAERNARRAQFSDVYLTIPNGMPFLNPPVGVGRVTINVFHKEMGQQELAWQRAFAKYLMCDCCGSSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFM4</accession>
    <name>A0A194XFM4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_732499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28829412"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_732499"/>
    <dbReference type="InParanoid" id="A0A194XFM4"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="100" mass="10621" checksum="1899E917EC509B9A" modified="2016-10-05" version="1">MKISNVLALVLLPAAALATPIPLEDREASPGYASYGSYPPPAGGYGKYSGYGSYKERRDAAGYGAYSGYGSYPPPAGGYGKYSGYGSYKRVADWVKSLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG76</accession>
    <name>A0A194XG76_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_683654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018214739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG76"/>
    <dbReference type="GeneID" id="28824465"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683654"/>
    <dbReference type="InParanoid" id="A0A194XG76"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="404" mass="45799" checksum="E43322DF3455CA04" modified="2016-10-05" version="1">MANIQPYTIAVSQAKIDRLHQKLALTDFPDEVENVGWDRGAPLADVKRLTEYWQEKYDWRATEAKLNELPNYTADIQAEGFETLKIHFVHQPSKVKGAIPLLFVHGWPGSFDEVVKILPELVEPKNSEHPAFHVVAPSIPGYGFSEGSRKPGFRVKQTGEICHKLMLALGYDEYVSQGGDIGCFVTRQMGKQYAQSIKASHINMPRPNPPSPHGDVELYMQHMQTPLTDKEKEGLKRWQWFTKEGSGYNLQHGTKPQTIGYSVTDSPVGLLAWIYEKLHDWTDSYPWTEDEVLTWVSIYWFSTAGPAASQRIYYEMYHDPDKPRVSSFEYIPDVLLGTANFPMELSVTPKLWNKTLGPLVLASEWDKGGHFAAYERPDAIIQDLRDMFGKKGGAYAVVKGQTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGN5</accession>
    <name>A0A194XGN5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073656.1">
        <property type="nucleotide sequence ID" value="XM_018214655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGN5"/>
    <dbReference type="GeneID" id="28824381"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683193"/>
    <dbReference type="InParanoid" id="A0A194XGN5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="53" mass="6415" checksum="1C7EAA5A3E826FE7" modified="2016-10-05" version="1" fragment="single">METPVILSLPLEKGKSQREIVQKTQVPRKTVRRIFKQEHSRRERKKKYSKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGR1</accession>
    <name>A0A194XGR1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_780925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073312.1">
        <property type="nucleotide sequence ID" value="XM_018222434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGR1"/>
    <dbReference type="GeneID" id="28832160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780925"/>
    <dbReference type="InParanoid" id="A0A194XGR1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268269" description="Glycoside hydrolase family 92 protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="284"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="86975" checksum="6EEC4978EBEB6877" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIR9</accession>
    <name>A0A194XIR9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_612048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074369.1">
        <property type="nucleotide sequence ID" value="XM_018210603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIR9"/>
    <dbReference type="STRING" id="149040.A0A194XIR9"/>
    <dbReference type="GeneID" id="28820329"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612048"/>
    <dbReference type="InParanoid" id="A0A194XIR9"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001559">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="631" mass="68619" checksum="990288085F9EFD8F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIV9</accession>
    <name>A0A194XIV9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_682850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074404.1">
        <property type="nucleotide sequence ID" value="XM_018214582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIV9"/>
    <dbReference type="GeneID" id="28824308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682850"/>
    <dbReference type="InParanoid" id="A0A194XIV9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="74" mass="8051" checksum="D96D235230ADDD00" modified="2016-10-05" version="1" fragment="single">MPAPHFKGSVHWYIDTCLSLLTAALTITRYSAKLHHDSTPQSNSCKLKLLDSFSNSVRSRTSANPPSIALPAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIZ2</accession>
    <name>A0A194XIZ2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_470567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074444.1">
        <property type="nucleotide sequence ID" value="XM_018207760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIZ2"/>
    <dbReference type="GeneID" id="28817486"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_470567"/>
    <dbReference type="InParanoid" id="A0A194XIZ2"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="530" mass="59633" checksum="7432D92BF8F1AF6A" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK37</accession>
    <name>A0A194XK37_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_695118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074829.1">
        <property type="nucleotide sequence ID" value="XM_018216751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK37"/>
    <dbReference type="GeneID" id="28826477"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695118"/>
    <dbReference type="InParanoid" id="A0A194XK37"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="17"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="3">
        <location>
            <begin position="399"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="503" mass="56297" checksum="26704DB88964E69C" modified="2016-10-05" version="1">MHTTNPLDEEFAELAEYTLDQWNVPGLSIAVVDGHDIWAEGYGYATLPSIKATSETLYYGGSLTKSHTAAAVSLLITSGNYSGLTLQTPVSALIREDFVLEDEWATKHITLEDVLGHRTGMARHDMSYGGDYGGHMGTPKDVVRSLRYLPMSSEPRSTFHYSNIMYVAAAYVVDTMSGQRIADFLKERVWGPLGMKSTFFSLTDAKKAASKRMAVGYSWQEDHYESTPHPDVTVITGAGSIIASVHDHARWLRALLSCSAPLTEADCKELKSPRTFIADQPEGSPYAGFMAYTLGWETDWYNGYQVFMHSGGIEAFGNHIIFIPELNWAAVASGNTAYTSTFACIELIHKLLDDKIGLSHAQRFNWLEYHKGKRLKQINFYNDAQSNFYPYTLDKRPLSLQLERYAGTYYNPGFRNFTIYVKDDTLQIDRYASYNVHMDLEQVTGDYFMAYMDSMTVPGSIYQNAVAAEFVIGPDGVARKFGIAEEPSMGPNGRVWFDRVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKA8</accession>
    <name>A0A194XKA8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_666238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074931.1">
        <property type="nucleotide sequence ID" value="XM_018212889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKA8"/>
    <dbReference type="FunCoup" id="A0A194XKA8">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKA8"/>
    <dbReference type="GeneID" id="28822615"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_666238"/>
    <dbReference type="InParanoid" id="A0A194XKA8"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="227"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="34389" checksum="02CFB33CE3ED591A" modified="2016-10-05" version="1">MSNGRQAGKSSTSFHFAAGLGSGVLSAVLLQPADLLKTRVQQSGHSSLLATIREISKSSTSIRSFWRGTLPSALRTGFGSAIYFTTLNALRRNVARSNLLASIGAIDKNAVQTYSSSLPKLSNLANLTTGAVARTGAGFILMPMTIIKVRYESNLYAYNSIAGAGKDILRTEGLKGFFSGFGATAIRDAPYAGLYVLFYEQLKKRLSLVSQKLPVAGEVQAGMKGSKSASINFGSGVLAAGLATAITNPFDAIKTRIQLQPKRYLNMLHAGKKMIQEDGFKSLFDGLGLRMGRKAISSALAWTLYEELIRRAELALGKAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKL2</accession>
    <name>A0A194XKL2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_451784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075036.1">
        <property type="nucleotide sequence ID" value="XM_018207615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKL2"/>
    <dbReference type="GeneID" id="28817341"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_451784"/>
    <dbReference type="InParanoid" id="A0A194XKL2"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="520" mass="59775" checksum="6A8F346636615612" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL10</accession>
    <name>A0A194XL10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_665345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075218.1">
        <property type="nucleotide sequence ID" value="XM_018212835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL10"/>
    <dbReference type="FunCoup" id="A0A194XL10">
        <property type="interactions" value="1011"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL10"/>
    <dbReference type="GeneID" id="28822561"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665345"/>
    <dbReference type="InParanoid" id="A0A194XL10"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="18665" checksum="D5F5F020DF729EB8" modified="2016-10-05" version="1">MPPKIDPNEIKVIHLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATGDWKGLRVTVKLTIQNRQAAVSVVPSASSLVIKALKEPPRDRKKEKNIKHSKSITLDEVIEIARTMRFKSLSKELKGGVKEILGTAFSVGCQVDGRSPKDVSDDIESGEIESRVPPTVLEHNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL43</accession>
    <name>A0A194XL43_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_456492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075206.1">
        <property type="nucleotide sequence ID" value="XM_018207640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL43"/>
    <dbReference type="STRING" id="149040.A0A194XL43"/>
    <dbReference type="GeneID" id="28817366"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_456492"/>
    <dbReference type="InParanoid" id="A0A194XL43"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268360" evidence="1">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="313" mass="34714" checksum="E3683874A465F721" modified="2016-10-05" version="1">MVSSHLQLRWFPLCLVALSILWRSIEAQQVIAPPPAVHGTLTFNITNDHTIRVTINNPPINLFNNNLLDDMLSFLTSLVPSNRATPPPKVVIFSSSNPDFFMMHRDVQGIIPPLVPWKLQAINNYISITRYLQNITTTVFIAECNGRAFGAGNEVMVQMDMRFAGPNASVGFFEDGLGVFPGGGGQQFLLELVGKARTMEYVLGALQIDGPTGAEIGWFNRYYESADAMTRSIDDLAARISTFPNGTVNATKSGLSWRNPTLEVLEADIAEFIRLDAMPDRAPLEEMFLNVTKNETATPFEMNTPLNMPELYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL61</accession>
    <name>A0A194XL61_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_579088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074867.1">
        <property type="nucleotide sequence ID" value="XM_018208986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL61"/>
    <dbReference type="GeneID" id="28818712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579088"/>
    <dbReference type="InParanoid" id="A0A194XL61"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="47"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="47"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ20512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="506" mass="55730" checksum="E57D5A9A498B07F2" modified="2016-10-05" version="1">MDAFDHDLSFEGEGLFNRDDVNTSGLPPLPFTPSYELSDAFSTTFEDPFSYQSNTDFSSILEDNNTHPHNESSHNTVDPDNKLLGFGVTNVKAPIFDDAGHTWPAMTAELYGMFFVAEDVFGDNNTNANRPLELTCYRRNLFQISGTVTLSRGIKSMVNEHGQQVPLYDMMATISALESIEGKSTEIISVPWKTSTGTSSEDKAGAAPPQWPLDLSMNPELDPSVVSIPIAWKRLQFKHATANNGRRKGLQQHYVIQINIMATLATGETVKLAEIRSGPIIVRGRSPRNFDSRKDVPLSEKKLDSKPRTMSDAGVSAPQVKVDPGVANSSYRFYALNALQQQPLDLPDWTNNPLATLSTSEIHARQAKRPTLTNQSSSASNPPRPPVPKARWKSESVPTKSSQATAPIDLSLADDEYGKAHPGGHLRPGEPASPVIDRDRLGKKGVGSPVENADLLYEYFPLSLDDWMPPVDAIYRPHVVHHTIVPPDLKAAQVKNKTKRYFSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM19</accession>
    <name>A0A194XM19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_715401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075484.1">
        <property type="nucleotide sequence ID" value="XM_018218202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM19"/>
    <dbReference type="FunCoup" id="A0A194XM19">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="GeneID" id="28827928"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715401"/>
    <dbReference type="InParanoid" id="A0A194XM19"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="294" mass="32395" checksum="1551E42203908534" modified="2016-10-05" version="1">MASNTLPTAKLNTGAEIPMLAYGTGTAHFKSSNLDQIDRKTVESIKTALSLGFYHLDGAEVYNTEAEIGIAIKESSIPREKLFITTKVFTNMTTIPTALETSLIKLGLSYVDLYLIHNPFFTTSALTLQTAWKAMEAVHRSGKARAIGVSNFLRSHLLSILSIATIVPAINQLEYNPYLQREGIVSWSLERGIRTAAYGPLVPIRKARPGPLDAVLEVLTAKYGVCEEAVLLRWTVQMGVVAVTTSGKRERLEGYLQAGGFELTEGEVDEISRVGREKHFRGSHWGFDYGDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM58</accession>
    <name>A0A194XM58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_730051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075618.1">
        <property type="nucleotide sequence ID" value="XM_018219432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM58"/>
    <dbReference type="GeneID" id="28829158"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_730051"/>
    <dbReference type="InParanoid" id="A0A194XM58"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16625" checksum="D05B85F3085BB018" modified="2016-10-05" version="1">MRAPVGGQGSESEEDEEGEDPAAGDEENEEDDQLVQTMEDEDTIPRIEGELAKCLGKAAFSLALQHGRRKGSGLEKNIETLSQFVVFLSGISLFVLQCEESTTGENKDNAMATYPTVMSELKRKFEKDDTEAARLGDSMEVSRDPSTFRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMA3</accession>
    <name>A0A194XMA3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_681806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075574.1">
        <property type="nucleotide sequence ID" value="XM_018214374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMA3"/>
    <dbReference type="GeneID" id="28824100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681806"/>
    <dbReference type="InParanoid" id="A0A194XMA3"/>
    <dbReference type="OrthoDB" id="10511669at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24067" checksum="C7F9BEDBA05C5CB8" modified="2016-10-05" version="1">MRWPKSTDVLSSESWTSHVRSFGVQIDPSPAAAYLDLNMCFINGEGSGTSLEWASERKLRICRAFKEGCERRRFSAPNHNYSYHNLKKAGGEQRKIHIRTLVAVMGCGIEWVKWMGANVLEDWDTGLLVKGVQRLLEHEKLNTEKGKEMEPFVTSYMDERGGRREAELLLDLSRYLMHYALPWTSEGAMTPYEPVCVVSRSREYDAGTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNM1</accession>
    <name>A0A194XNM1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_694257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076118.1">
        <property type="nucleotide sequence ID" value="XM_018216692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNM1"/>
    <dbReference type="FunCoup" id="A0A194XNM1">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="GeneID" id="28826418"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694257"/>
    <dbReference type="InParanoid" id="A0A194XNM1"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="39936" checksum="1F3D3F4C0FB04D15" modified="2016-10-05" version="1">MEYTRLGNSGLKISKVIFGCMSFGTPEWQEWVLDEAAALPLLKHAYDVGLNTWDTADIYSNGQSEEIIGKALKKYEIPRNRIVILTKCYFGVAEDGTQPPIAAASVNDGLMVNRTGLSRKHILDAVDQSVKRLGTYIDVLQIHRLDRDTPREEIMRALNDVVDSGKVRYIGASSMAAWEFQTLQNIADKHGWHKFISMQNYYNLLYREEEREMIPYCRDTGVGLVPWSPLARGALARPFTDRSTLREKSDSGLTRLIRSKESEIDKQVNERVQEIAKKHGVSMTTIATAWCLSKDKVNPIIGLSSKERIDQAVESVQFASSGKLTAEDIAYLEEGYAPKELIGLLTGSQSYATHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ05</accession>
    <name>A0A194XQ05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_636251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076695.1">
        <property type="nucleotide sequence ID" value="XM_018211482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ05"/>
    <dbReference type="FunCoup" id="A0A194XQ05">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQ05"/>
    <dbReference type="GeneID" id="28821208"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_636251"/>
    <dbReference type="InParanoid" id="A0A194XQ05"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="30984" checksum="911B55EDF1ADD717" modified="2016-10-05" version="1">MLRPRIPRIGHALHSFRRSFHQVPPLVHDFREGVPGLLSPAGFDMAWTKYQSLMCSKLNDLTAGGPWENSEPKDVAINFARDPNSAPIFNYASMAHNNHFFFQCLSPNPPEMPLALKTDLEKSFGSIETLRREMVVTASSMFGPGFVWLIKERSSKKYKILCTYLAGSPYPGAHFRRQTVDVNTGEGSGTEAYKRMASQPPTNTVGAHGAHARKDTLPAGGIDATPVLCINTWEHVYLPDYGIGGSGSGGKRAFAESWWYAVDWNVVADKADVKGSLPMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ98</accession>
    <name>A0A194XQ98_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_606857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076723.1">
        <property type="nucleotide sequence ID" value="XM_018210435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ98"/>
    <dbReference type="STRING" id="149040.A0A194XQ98"/>
    <dbReference type="GeneID" id="28820161"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606857"/>
    <dbReference type="InParanoid" id="A0A194XQ98"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="239" mass="27349" checksum="671FFD8839BB7566" modified="2016-10-05" version="1">MAHHDEFRQWPFLNEEEFELACAFFDQRYVRAHLGPTRQIFKIRHRRIATSGNSYIEILRLLQLPEQPDELSAMLERLGGGFGESADVEMNIDSKDEEDDQEALRDPDSLPGYTPYAQQPYVMYEIHLHPTYRLPTLWFTLHDLPAGEPTFDLDAIYRYLVPPQYKDNLRALGVTGGISAAPHPVTDVPAFFIHPCQTKEAMEKFDCTMQDYLMVWIGLVGSCVGLWVPPEMAISVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQB0</accession>
    <name>A0A194XQB0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_680385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076599.1">
        <property type="nucleotide sequence ID" value="XM_018214070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQB0"/>
    <dbReference type="FunCoup" id="A0A194XQB0">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQB0"/>
    <dbReference type="GeneID" id="28823796"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680385"/>
    <dbReference type="InParanoid" id="A0A194XQB0"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="21794" checksum="49DF7F7FC804C75C" modified="2016-10-05" version="1">MAPKVAIVFYSMYGHIKALAEAEKEGLKKAGIEADIFQVPETLPQEVLTKMHAPPKSDYPAIDAATLEKYDAFLFGIPTRYGNFPAQWKAFWDTTGSQWASGGYWGKFAGVFVSTGTQGGGQESTVIASLSTLAHHGIIYIPLGYKHTFSQLSTLTEMRGGSPWGAGTFSGADGSRMPSTLELELATIQGEQFGLAVSKVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQJ4</accession>
    <name>A0A194XQJ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_607075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076823.1">
        <property type="nucleotide sequence ID" value="XM_018210443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQJ4"/>
    <dbReference type="FunCoup" id="A0A194XQJ4">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQJ4"/>
    <dbReference type="GeneID" id="28820169"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_607075"/>
    <dbReference type="InParanoid" id="A0A194XQJ4"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="745" mass="82404" checksum="7F2020BF4659B359" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQM7</accession>
    <name>A0A194XQM7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_607274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076930.1">
        <property type="nucleotide sequence ID" value="XM_018210451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQM7"/>
    <dbReference type="FunCoup" id="A0A194XQM7">
        <property type="interactions" value="1117"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQM7"/>
    <dbReference type="GeneID" id="28820177"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_607274"/>
    <dbReference type="InParanoid" id="A0A194XQM7"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="28437" checksum="06927572D65D40DE" modified="2016-10-05" version="1">MLEARLEQADLLKKIVDAIKDLVQDCNFDCNDSGVALQAMDNSHVALVSMMLKAESFSPYRCDRNVALGLNLTSLTKVLRAAGNEDILTIKAEDAPDVLNLVFESSESDRLSEYDLKLMDIDQEHLGIPDTEYAATISMPSTEFRRICVDLMALSESVSIEASKDGVKFSCAGDIGNGAVTLRPHSNVEKPELDVEIELTEPVSLTFSLKYLVNFCKAAGLSKSVKLCLSNEVPLLVEYQLAGSSYLRFYLAPKIGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQQ3</accession>
    <name>A0A194XQQ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Las1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_392486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076407.1">
        <property type="nucleotide sequence ID" value="XM_018207199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQQ3"/>
    <dbReference type="STRING" id="149040.A0A194XQQ3"/>
    <dbReference type="GeneID" id="28816925"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_392486"/>
    <dbReference type="InParanoid" id="A0A194XQQ3"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="34362" checksum="FA4844649A987408" modified="2016-10-05" version="1">MVQYITTPWRTRAELLRVRSALYPSSSSGPMKEEEIKTAVAKVGVWMQRGNCPHLVESSAVLWSAVLNDRVGNSSYCVRAAYAAAFCRFVTGLLDSHQDKRRKLSMYSIAKTLGLPATYVELRHQATHEELPSLSKLRIATHKALKWIWDYYWVHLKEEITSMSENREYVEKLVREKDAGIRARMEEFVGNWDQDRLMGILVEIQGATDDVVILARSSRLQRLVVDGGKGNSRKRKLDSEVKSLDEVKAEMEMMNRELDNEMEDDGPQSEVAHPEARKEPPTSKGWTMWEGPWTPKPIGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQY8</accession>
    <name>A0A194XQY8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076921.1">
        <property type="nucleotide sequence ID" value="XM_018214126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQY8"/>
    <dbReference type="GeneID" id="28823852"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680701"/>
    <dbReference type="InParanoid" id="A0A194XQY8"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16039" checksum="156635EE82AEB159" modified="2016-10-05" version="1">MDELIHVLQPHPEDRLHLRLHRARSVILTAQELVEIRAAQRTFEGAYIRTALGQFSFALVVLKIFTAEFYSIGALFATYGVGIFLVSLYRRYEGNRQFFSEMGEDGLGRKRFRTSGNAVVVLTALSVGAYASLIVLTARLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR61</accession>
    <name>A0A194XR61_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_396234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076572.1">
        <property type="nucleotide sequence ID" value="XM_018207233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR61"/>
    <dbReference type="GeneID" id="28816959"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_396234"/>
    <dbReference type="InParanoid" id="A0A194XR61"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25222" checksum="48DDFCBEC3983CD6" modified="2016-10-05" version="1">MPRLQMISAVLQTVFLIACGLVISHNLYLSVEGKFTSNDLYKNWTEAVELAAKNHNRSNQTTLAIGPGAVVISNDTAFNATSTSTSSSNSNESFYLKSLPRDLLVYTIITIMAYYWQIWLERTFPARPRPSVKVVSEKFGDDESREEEVVKKWIAQGKIRRASLSWWNTFVKWALDMVVGGLWMTTVYILLGGLLKMDTSPKALFKGLKWVRLSIPSEKYNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRX3</accession>
    <name>A0A194XRX3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_165300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077400.1">
        <property type="nucleotide sequence ID" value="XM_018205521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRX3"/>
    <dbReference type="GeneID" id="28815247"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_165300"/>
    <dbReference type="InParanoid" id="A0A194XRX3"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="87"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="930" mass="104488" checksum="5516A41D77A3022C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS10</accession>
    <name>A0A194XS10_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_161032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077286.1">
        <property type="nucleotide sequence ID" value="XM_018205502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS10"/>
    <dbReference type="FunCoup" id="A0A194XS10">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XS10"/>
    <dbReference type="GeneID" id="28815228"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_161032"/>
    <dbReference type="InParanoid" id="A0A194XS10"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="210"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="408" mass="44877" checksum="4CEB5E4402B6B830" modified="2016-10-05" version="1">MPAPNVPKPGPAKLSKNAGLEEWLEEAKQCHYLPEAIMKQLCEMVKECLMEESNIQPVSTPVTICGDIHGQFYDLLELFRIAGGMPGETNVQKPTTQTTIISSDDIEPPTEITNPKLKKKIRSSDSGIESASGEDDDEEEERGRPRTAGASSRGGSAGGDSAIGVNEISGSGNQNFIFLGDFVDRGYFSLETFTLLMCLKAMYPDKITLVRGNHESRQITQVYGFYEECQQKYGNASVWKSCCQVFDFLVLAAIVDGEVLCVHGGLSPEIRTVDQIRVVARAQEIPHEGAFCDLVWSDPEDVETWAVSPRGAGWLFGDKVATEFNHVNGLKLIARAHQLVNEGYKYHFSNKSVVTVWSAPNYCYRCGNVASIMNVGEDLNPKFSIFSAVPEDQRAVPAGRRGAGEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS12</accession>
    <name>A0A194XS12_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_163492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077338.1">
        <property type="nucleotide sequence ID" value="XM_018205514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS12"/>
    <dbReference type="GeneID" id="28815240"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_163492"/>
    <dbReference type="InParanoid" id="A0A194XS12"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="84" mass="9216" checksum="EF271184499DBDD9" modified="2016-10-05" version="1">MASSEWYRDNLLISTNPSLIQPAAVNAAFDSDMMHWVKAIDETLLKKMLDNSLCFGVYELPSSSSDIAGRAGPRQIGLARIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSB5</accession>
    <name>A0A194XSB5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_306231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076977.1">
        <property type="nucleotide sequence ID" value="XM_018206599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSB5"/>
    <dbReference type="FunCoup" id="A0A194XSB5">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XSB5"/>
    <dbReference type="GeneID" id="28816325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_306231"/>
    <dbReference type="InParanoid" id="A0A194XSB5"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002054">
        <property type="entry name" value="DNA mismatch repair protein MSH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000013">
        <property type="entry name" value="mutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="831"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="864" mass="96342" checksum="3E27126DFE7DD03D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSD5</accession>
    <name>A0A194XSD5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_777704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076997.1">
        <property type="nucleotide sequence ID" value="XM_018222156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSD5"/>
    <dbReference type="GeneID" id="28831882"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777704"/>
    <dbReference type="InParanoid" id="A0A194XSD5"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40424" checksum="7C0EF322ACDA3C9C" modified="2016-10-05" version="1">MKSSLYTVVSAISLVSAHPHAALNPKVLVSRQFNTQDPYTNWPTYDQLPLDPSYPTKAAWGVWGADDVQGALNHITNATILAARGEIQLGRAINLNMDLNAFTTPINPNRKPLNHLFQPGDGYTDDVVVLNTQVSTQYDGLRHFPYSTDGNTTTYQWYNDLIENFDQVVGPAPTEVLGIQQAAQKGIAGRGVLLDFVGWALTQNMTFDAFTGYGINTSSLDAIAAWQGLPSNWSLPGDMLLIRTGWTKAYLNLTSYNQEILPWDPNLGSVGMNCSDDSLAWLWEKKLALIGADNPAFESLPMDKTIGGVARSLHQVFIGGWGQSIVEFLDLETLAEELHQLGRSTFFLTIQNLNIKSGIASPPNALAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT76</accession>
    <name>A0A194XT76_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_755455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077870.1">
        <property type="nucleotide sequence ID" value="XM_018221351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT76"/>
    <dbReference type="STRING" id="149040.A0A194XT76"/>
    <dbReference type="GeneID" id="28831077"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_755455"/>
    <dbReference type="InParanoid" id="A0A194XT76"/>
    <dbReference type="OrthoDB" id="5417021at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ23515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="30383" checksum="30E8C70A64B9F89F" modified="2016-10-05" version="1" fragment="single">MSASAGALVLCSKAVVQDSQGDSTNINDPMPNIWSSMQRWIDHLPSRTSEEARRRQELQNELSWCYSKLNENRSTTNMRSFQHIFGHCDLLCGNILILSNDKPRIDRPDAPEERNRISPTEVRFIDFEFAMHCPAAFDIANHFSEWGGFDCDYNMLPGRVIRQKFIDKYLASYIQHANITLPDFASAASKLAYEVNMFRGIPGLWWGIRGFVSVLESKIDFDWIPYANKRLAEYWGWKAEAEGLRDRNGEEMTLREKMWDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTR4</accession>
    <name>A0A194XTR4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_679046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078065.1">
        <property type="nucleotide sequence ID" value="XM_018213800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTR4"/>
    <dbReference type="GeneID" id="28823526"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679046"/>
    <dbReference type="InParanoid" id="A0A194XTR4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="53" mass="6242" checksum="A2A4DEF6FB6C41D6" modified="2016-10-05" version="1">MELLVELGIFEVWISTEHSQTSSVFATLRKSARLKKDIRVHFNDRTEGPYMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUR6</accession>
    <name>A0A194XUR6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_776095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078236.1">
        <property type="nucleotide sequence ID" value="XM_018222010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUR6"/>
    <dbReference type="FunCoup" id="A0A194XUR6">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XUR6"/>
    <dbReference type="GeneID" id="28831736"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776095"/>
    <dbReference type="InParanoid" id="A0A194XUR6"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="12">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="181" mass="21102" checksum="5C0EA93CB7D143AF" modified="2016-10-05" version="1">MSNNPLPSSFDGNSDFYEENRWQKFSRRLKEEPLIPLGCVLTCMALFGASRSIRAGDHNRTNRMFRARIYAQGFTLVAIVAGSMYWQTDRQKRKEFDVAVAERKAKEKNEAWIKELEARDEEEKELRELRRRRAEGRQAIKKEEKILEQVDSGKGASSVVEDEERKKSVLESVQEMVWGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVG6</accession>
    <name>A0A194XVG6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_727352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078675.1">
        <property type="nucleotide sequence ID" value="XM_018219145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVG6"/>
    <dbReference type="GeneID" id="28828871"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727352"/>
    <dbReference type="InParanoid" id="A0A194XVG6"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="11633" checksum="8607D391ADB5CD0E" modified="2016-10-05" version="1">MVAAATRIKIRQEISTTMDGKVVSWGNNYFGPAVPAAPAAASVNLPRRSESSAGRVRLQARDAAVPRGHNISDLIDFVRSGPQLDKENSGSLHTRVYPQKPLVLILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX53</accession>
    <name>A0A194XX53_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_634440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078722.1">
        <property type="nucleotide sequence ID" value="XM_018211387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX53"/>
    <dbReference type="FunCoup" id="A0A194XX53">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XX53"/>
    <dbReference type="GeneID" id="28821113"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634440"/>
    <dbReference type="InParanoid" id="A0A194XX53"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="348" mass="37231" checksum="74F81C8417A53A99" modified="2016-10-05" version="1">MHSKVVIIGSGPAAHTAAVYLARAELKPVLYEGFLANGIAAGGQLTTTTDVENFPGFPDGIGGSELMDAMRKQSEKFGTNIVTETVSKVDLSSRPFKYWREWSEDEAPDTADAIIIATGASARRLGLPGEDKYWQNGISACAVCDGAVPIFRNKPLVVIGGGDSAAEEAMFLTKYGSHVTVLVRRDVLRASKTMAKRLLANKKITVRFNSVGGEVKGDDKGLMSHMVIKDVKAGKEETIEANGLFYAVGHDPATALFKSQLDTDEEGYVITKPGTSYTSVEGVFAAGDVQDKRYRQAITSAGSGCIAALEAEKFLAEQEDEENTLEAEKGAAKGNNVVVPEYRSNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1I9</accession>
    <name>A0A132B1I9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein-like protein TMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_633144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060603.1">
        <property type="nucleotide sequence ID" value="XM_018211329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1I9"/>
    <dbReference type="FunCoup" id="A0A132B1I9">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B1I9"/>
    <dbReference type="GeneID" id="28821055"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633144"/>
    <dbReference type="InParanoid" id="A0A132B1I9"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287768" evidence="8">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="478" mass="51898" checksum="49C0DEB9AB466269" modified="2016-05-11" version="1">MGALLSLPLLAVPSMGTVFGFMASCCGAATCSAVCSACGKCGNSVATRIAYALILLVNSILSWIMLTPWAINKLQHLTLDYMTISCPDGPCYGWVAVHRINFALGVFHIILGFILLGVNSSKNPRAAIQNGFWGPKIIAWLALIVVSFLIPESFFFVWGNYISFFAATLFLLLGLILLVDLAHSWAEYCLDQIEASDSRAWRGVLIGSTLGMFAASLAMTIVMYVFFAKGGCTMNQTAITLNLIFLLIVSGISVHPYVQEGNPKAGLAQSAMVAIYCTYLTMSAVSMEPDDKNCNPLIRAQGTRTTSIVIGAIVTMLTVAYTTTRAATQGVALGGSGKSVRLPNEDEHDLVTQQPDSRREMRAAALRQAVEEGSLPADALDDDDDDSDSGNTAKDDERNSTQYSYALFHVIFFLATAWVATLLTMNFKDDSTKDVEDFAPVGRTYWASWVKIVSAWVCYGIYTWTLVAPIVLSDREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1S2</accession>
    <name>A0A132B1S2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_769615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060681.1">
        <property type="nucleotide sequence ID" value="XM_018221826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1S2"/>
    <dbReference type="GeneID" id="28831552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769615"/>
    <dbReference type="InParanoid" id="A0A132B1S2"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="228"/>
        </location>
    </feature>
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            <end position="254"/>
        </location>
    </feature>
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            <end position="326"/>
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    </feature>
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            <end position="368"/>
        </location>
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            <end position="408"/>
        </location>
    </feature>
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            <end position="435"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="79"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ06326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="516" mass="55988" checksum="7349C93D34638ED9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1T5</accession>
    <name>A0A132B1T5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_769671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060703.1">
        <property type="nucleotide sequence ID" value="XM_018221830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1T5"/>
    <dbReference type="GeneID" id="28831556"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_769671"/>
    <dbReference type="InParanoid" id="A0A132B1T5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="337" mass="37282" checksum="B001B60455A32B19" modified="2016-05-11" version="1">MSSSTSNLYGSINSSRLQNHPKTRLVKKYVFKAAKFIFYIIKLITKFIVLTIQKLFNLSLYPMLSVIVTIFALTIYSFFLDQVVERLSGWVVGLTFGGLQIVALPKTTILETPTHWYVIPLPEVASLVTPSATLSMITTIVVEVLSETYALTTEDYTYPALAFSQGTSQMLPEVFESLTILASVEPIQIAHSEAISTSEIQLPSTDSPEAQKFSTPSRISIAFLEPEHSPEPQLHTTSSPLPISPTQEEITALLELPTTIAVSMDTLSEDTESYTPSISTRKEEHTSSSSWQSGILIATRVETLHESLFTFATISSRSLVESETQTPQPTNLNHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3B2</accession>
    <name>A0A132B3B2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative o-acetylhomoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_692177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061176.1">
        <property type="nucleotide sequence ID" value="XM_018216481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3B2"/>
    <dbReference type="STRING" id="149040.A0A132B3B2"/>
    <dbReference type="GeneID" id="28826207"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692177"/>
    <dbReference type="InParanoid" id="A0A132B3B2"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="453" mass="49318" checksum="05853E13A3565E24" modified="2016-05-11" version="1">MPASGSLRGVTKEPGFDTLQLHAGQEPDPVNGSRAVPLFQTCSYNFMDAADGASKFAWQKDGYVYTRMGNPTISVLEQRMTMLEGGVGAVATASGHAAQFMALTSIMEPGDNFVSTSWLYGGTYNQFRVYLKKFNIHVKWVEGQDPKAVAAAIDDRTRAVYLETIGNPKHNVPDIAAIAKVAHDAGIPLIVDNTFGMGGYVQQPFKLGADIITHSVTKWIGGHGTSMGGIVIDGGKFDWSKSGKFPGFTEEADGYHGMKFWDAYGYKALAAKLRMDAMRDLGPCMSPFNAWLFLMGLETLSLRGARHCENALAFAEWLEAHPLVKWVLYPGLKSHPDHEYATKNLKNGYGGVLTFGVDGNIEEVSAVVDNLKLCSHLANVGDAKTLIIHPWRTTHQQLPDEEKVQAGVTPDLIRVSLGLENIEDIIHDFQQAFDGAGLKPLKTLPVTNGTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4C5</accession>
    <name>A0A132B4C5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_691750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061630.1">
        <property type="nucleotide sequence ID" value="XM_018216400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4C5"/>
    <dbReference type="STRING" id="149040.A0A132B4C5"/>
    <dbReference type="GeneID" id="28826126"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691750"/>
    <dbReference type="InParanoid" id="A0A132B4C5"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="404" mass="43227" checksum="64036249F915A9D9" modified="2016-05-11" version="1">MADDEFDIDIYGDTNPEQEVDLSAKKDEDEEGDMKIDDLEPTNGHATEPNSIDHEEEQDDDFVDIKTSFNDQSSKMQPQQKIKSTDEPGGDVLNIPKQAPQIQGVKRKEGSDDRPIDPGATTALLISELHWWNTDDDIRGWVNQAQVEDELKEITFSEHKVNGKSKGQAYVEFSSQQAATAAKHKIDAFGEGQQYVKKHTVVYSNPNVNPFKTLPKDAPLRAGKDGQSNPSRGGYNNDRGNTNGNFGGNFRGRTPGYNARGGMNNNMNNFNRNFSGPAMGNMGGGFNSGMGGFPSGPMGNQFGGGFNNRGGMMGGGMRGGGMRGGRGGMNGMMAGMPMGGMPMGGMPGAMGGMPMNMGQMAGGMPGAGGFNGMQPHFNPAFFQGNQAAGGDWQNPHGAKRPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4Z4</accession>
    <name>A0A132B4Z4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_789579</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061835.1">
        <property type="nucleotide sequence ID" value="XM_018223273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4Z4"/>
    <dbReference type="FunCoup" id="A0A132B4Z4">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B4Z4"/>
    <dbReference type="GeneID" id="28832999"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_789579"/>
    <dbReference type="InParanoid" id="A0A132B4Z4"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000102">
        <property type="entry name" value="Similar to galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="134"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="414"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ07480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="56005" checksum="7B10D5E0FB5FDEF6" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B581</accession>
    <name>A0A132B581_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_742790"/>
    <dbReference type="InParanoid" id="A0A132B581"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="29707" checksum="C0A9642317737D4C" modified="2016-05-11" version="1">MAPIFNITNEASTEKYLAANMPLIANAIVEAVKNKTSNITASTSEMVKRVANKATHEAYCELNFCHDKPPTHPAKNVTVVFGKCADDGFNQYGCDASGKPFKHPMIRAVAPIIEDLLKRASKAANDIKCQFKLCDDNLHPSKYIGMHSTDVFGNCPQDGEFYQFGCDASGKPYKHEHLAGRSLQTVLADEALATQHHSDDGKSNITQMLFILLVAVVAFIAMFMLYGKVKKILGERKERKAGRDLAQMEDGIPEMAVIVVEEEEYSDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5W6</accession>
    <name>A0A132B5W6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_660072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062160.1">
        <property type="nucleotide sequence ID" value="XM_018212539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5W6"/>
    <dbReference type="GeneID" id="28822265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_660072"/>
    <dbReference type="InParanoid" id="A0A132B5W6"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="37004" checksum="203805F6C4FD7A4A" modified="2016-05-11" version="1">MNNTTISLDHIEQLQGWTASPNGRGTINIIQNSFLTISLCAWTMLCLNVPPLGASRTAQARHKIMIFCEAILGPEFIFQTALGQWASARRSVASFTASGLQGWTMKHGFFADMGGYVLDPPDFPPFPLSAKQVHYLVTNNYIDYALVAITSDAIDDKNKSDGMARIITMVQVLWFVLDTIARAAQGLAISTLELSTIAYVWCSIGTWFFWRNKPQDINVPVIVVPNQTMAEIVRNAGSAADEKYISTPPDFVGREHHHWTLYWAHWFNILHHMGIVLHTRKRPVDKISDDQFLPLSVGSNAILIFFQLGFAGIHIAGWNFRFPTPTERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B654</accession>
    <name>A0A132B654_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_353952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062237.1">
        <property type="nucleotide sequence ID" value="XM_018206952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B654"/>
    <dbReference type="GeneID" id="28816678"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_353952"/>
    <dbReference type="InParanoid" id="A0A132B654"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="254"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="446" mass="48584" checksum="C30DAC25DE43953F" modified="2016-05-11" version="1">MVNKHRITPTFSVRDVEVANISVDDSSGVDDSTVGSTSETNPFPDGGLAAWTCVLGSFFALFCTFGWLNALGLFQTYYERTLLITQSASTISWIFTLQLFFMWAGGAVFGRIIDTYGTHHVAIPCAIGCALFVFMINICDQYYQLILVQGVGFGVSAAGLFSCATTSVGQYFDKRKALALGIALSGSSTGGFVHPLYLQRLIDHFGFKQAIRWASLVIAVSGALACMLMSARLPRKKWDKNLSFIDFSLFKRSTFTMYCIGTFFVTWGLFAPWSYLPSMSLRHGFSEGTAIYTIVLLNAASTIGRILPAHLADRLGRFNLVSIITILNAACLLGFWYPLEISTTTAHVQILAFGALYGFTSGAFIGIMMSCVAELGQVETLGQRFGTYQFVVGVGSLTGLPIQGALIPADNHGFRYLILFSGSCMVVGAGFICTARMLRKSRSWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6W2</accession>
    <name>A0A132B6W2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_346144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062328.1">
        <property type="nucleotide sequence ID" value="XM_018206881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6W2"/>
    <dbReference type="GeneID" id="28816607"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_346144"/>
    <dbReference type="InParanoid" id="A0A132B6W2"/>
    <dbReference type="OrthoDB" id="3557516at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12046" checksum="AE20C929F039B363" modified="2016-05-11" version="1">MASNTTNTKTAAPTPPFPSTNGAGPSKDSILNDLRRQLDDSDISSNAGSNSSGRRRRRRKNKSALGQPLAATGPTVIPRLAETKPVRLQLGLNLDVELELKARIQGDVSLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7Z9</accession>
    <name>A0A132B7Z9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative peroxisomal membrane protein PMP47A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_658918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062893.1">
        <property type="nucleotide sequence ID" value="XM_018212495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7Z9"/>
    <dbReference type="STRING" id="149040.A0A132B7Z9"/>
    <dbReference type="GeneID" id="28822221"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658918"/>
    <dbReference type="InParanoid" id="A0A132B7Z9"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ08538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="316" mass="34298" checksum="A2FF7BC1115D0FF9" modified="2016-05-11" version="1">MAPSTAAQQSDNVAHALSGAGGGILAMTLTYPLITLSTRAQVESKRADSGFLDAVQRIVQREGITGLYAGLDSALFGISVTNFVYYYWYEWTRSGFEKAAVTAGRASKKLTTVESMIAGAIAGSATVLLTNPIWVVNTRMTTRQRNKESDEAVLPGAKPPKAPTTIGTLLALIKEEGPQALFAGVVPALVLVINPILQYTIFEQLKNTIEKKRRVTPTMAFMLGALGKLFATSITYPYITVKSMAHVAGRDGDKENMMQAMRRIVKEEGYTGLYKGIGPKVTQSVLTAAFLFAFKDVLYEQTVRIRRTMAAKALTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8C6</accession>
    <name>A0A132B8C6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_599572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 8"/>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062976.1">
        <property type="nucleotide sequence ID" value="XM_018210101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8C6"/>
    <dbReference type="GeneID" id="28819827"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_599572"/>
    <dbReference type="InParanoid" id="A0A132B8C6"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000286">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="302"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="392" mass="43784" checksum="2894A671F1FBD8E2" modified="2016-05-11" version="1">MGFSSWNQFGDQISEQLFRDTIDTMASNGLRDAGFIYINLDDGWQHYKGNRSQNPLEPDPVKFPSGMKALADYAHSKGFKLGIYSGPGDSTCAGYTGSLGHEFEDAAMFASWGIDHLKYDSCCSEGPDAPIPEVQAIVLKMSEALLAQSRPMVYHACHCGWADIWEWAASEGANQWRIGQDISDDFNYPGNREKYYFDVLDMLDVGNNITQYSGPGHWNDYDMLIVGLDGNSTQLVGTGASNIEYRTHFSMWCMVASPLLIGSDVRTLSDYDLETLTNSEVIEVSQDPLGQAAQVVGTQDVDGNLQVYAKAMADGSYAVALLNRGTVTADMSISARRDLTVPWDRYRLRDLWKHKDHGCYDIPYTIEVMPHEAKILRMWQVDLNATACQYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8G1</accession>
    <name>A0A132B8G1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_702066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062312.1">
        <property type="nucleotide sequence ID" value="XM_018217232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28826958"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_702066"/>
    <dbReference type="InParanoid" id="A0A132B8G1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="942"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="277"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="613"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="910"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1222"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1454" mass="160061" checksum="964A7D71673B189E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8G3</accession>
    <name>A0A132B8G3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_629164</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063053.1">
        <property type="nucleotide sequence ID" value="XM_018211197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8G3"/>
    <dbReference type="STRING" id="149040.A0A132B8G3"/>
    <dbReference type="GeneID" id="28820923"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_629164"/>
    <dbReference type="InParanoid" id="A0A132B8G3"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="795"/>
        </location>
    </feature>
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        <location>
            <begin position="712"/>
            <end position="783"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="795" mass="85478" checksum="89411C2485EF640B" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8Y5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_328130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206764.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_328130"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="684" mass="73855" checksum="6568021FF4D515E4" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B951</accession>
    <name>A0A132B951_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_540787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
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        <property type="protein sequence ID" value="KUJ08935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018208168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B951"/>
    <dbReference type="FunCoup" id="A0A132B951">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B951"/>
    <dbReference type="GeneID" id="28817894"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_540787"/>
    <dbReference type="InParanoid" id="A0A132B951"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ08935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="360" mass="40930" checksum="EDBA738B36E0E09F" modified="2016-05-11" version="1" fragment="single">TPPARAVVPQQDFSPPTPEVKRRIEENRLKAKALRVRSIAAQEAAARTPSGFLAEDVSSSGRTRSQAAVLSTNVPESSRDARNTSTKDDGIQPARNFKKYVDHDFSKMTDTKGGFLSVDDDPFNKALHAPKEGEKPAHMTLKEWETHQTLKSLRQRKEGLFEPGLGLGAKERGKKCRECGGLEIDWLWEDTFKCEICHRCKEKFPEKYSLLTKTEAKVDYLLTDPELKDVDLLPHLSKANPHKSHWHDMMLFLRYQVEEYAFKTKWGSAEALDAEFEKREGDKKRRKEALFRNKLRELKKKTRTDAYRRNARGGGKVGQFGDRIGSGKHEHEWGQTVENADGMTVKTCVGCGMEVEELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9D9</accession>
    <name>A0A132B9D9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_598735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063375.1">
        <property type="nucleotide sequence ID" value="XM_018210056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9D9"/>
    <dbReference type="STRING" id="149040.A0A132B9D9"/>
    <dbReference type="GeneID" id="28819782"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598735"/>
    <dbReference type="InParanoid" id="A0A132B9D9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="58365" checksum="2235241159677D05" modified="2016-05-11" version="1">MIFTTSLLFSGLPIFALTLIVWIGHACFKYHQYERMRVQFGCSPFKHYPSWDRILGLDYVYDMVKAIKENRFLEFQKETYSASGAKVWRANFLGNRMIYSSESENMKAVSTSHGDCFAVEPIRVGNGAITPFPGRGVSSSDGAKWQASRDLVKPYFDRAGYSNLQRLSQHVDRLLDKIPKDGSVIDMQPLFQRWFLDTSTDFLFGETVNSLDKPENQWPFRDMIAVMAGLRLRLQLSSFLFLHRDPEWLAACKRIHVFLDTYIEKAYKQLEDEKNGMQATYASGEARNDFLWTIARQVPDKLELRTQLTAVWIPSNETTSILMSNTLFALARHPEVVQKLRKEILKYGDKLLTFEGLRSIDYLRWIINESHRLYPVSLQTVRACVKNTSLPTGGGTHGKAPIFCAKGDIVHCNRYLMHRDPDFWGSDAEIFRPERWAEVRPLWNFVPFGGGPRICPAHVMVDTECSYTIFRILQNFKAIEPRDDEPYTAVMRVGPSNKNGCKLSFVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9Z6</accession>
    <name>A0A132B9Z6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_788719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063174.1">
        <property type="nucleotide sequence ID" value="XM_018223190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9Z6"/>
    <dbReference type="FunCoup" id="A0A132B9Z6">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9Z6"/>
    <dbReference type="GeneID" id="28832916"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788719"/>
    <dbReference type="InParanoid" id="A0A132B9Z6"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288037" description="glucan 1,3-beta-glucosidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="98"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ08819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="424" mass="46612" checksum="D362292F0613DF43" modified="2016-05-11" version="1">MLLKNTLAAIVSAAAVVAALPATAQPLSKRSVSFNWGSEKVRGLNIGGWLLLEPWITPSIFQGLNQSLGIVDEFTLTQQLGTEAAYNILKPHWDSWCTFADFQKIANAGFNTVRIPVGYWAYALEDGETYTQGAAPYIDAAVDWARGTGLKIWIDLHGAPGSQNGFDNSGHRISTPGWQQGDTVAQTLSILNTITAKYAQPSYQDVIVAIELLNEPLSSELNLDTLKQYYRDGYDQVRAISDTPVMLHDGFVSPSTWNGFLSVSDNNSQNVAVDHHEYQVFTDALVALVPWQHRQLVCNNAPTYASGADKWVVVGEWTAAMTDCAPALNGYGIGARYDGTYPGSSYVGTCADKSNIAMWNETFKGDMRGYIEAQLEVFESHTQGWVFWNFKTESAHEWDAFVLLDNGLFPQPLGSYEFSAICTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB09</accession>
    <name>A0A132BB09_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB09"/>
    <dbReference type="GeneID" id="28823262"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675771"/>
    <dbReference type="InParanoid" id="A0A132BB09"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ09602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="20604" checksum="0FF9C79180DE5287" modified="2016-05-11" version="1">MIHGPDGFCLAFNNLADTIYVPRYIPRFPRFFCAHFHTAEGSEDRMVIKKSRIDSFGLRALAQTNLEDYPDLDELVIKIHFNAPPIDDPNEKVFLVGKDEFDLMENWEEVKPRSVYDVDVPEPEDRNFCVPITPETLATTAINPRVISLATEPCSDDNACCYKAPKRQPWRRRRFRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BB11</accession>
    <name>A0A132BB11_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_274087</name>
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    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063965.1">
        <property type="nucleotide sequence ID" value="XM_018206390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BB11"/>
    <dbReference type="GeneID" id="28816116"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_274087"/>
    <dbReference type="InParanoid" id="A0A132BB11"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="170" mass="19594" checksum="8DEDD0CE0B80A6DD" modified="2016-05-11" version="1">MWEFCERRREIAECWAGLRSARMLMFAARVRLQSCHLAIPRLRSPAPPSEQLQPQQDGDSAALNLLNISTYFSIRNTNYDPPHPSLPNPRHRQPGRAGRNSSSNRRRRQTQPQRLHTLKDNWHSHLSLPPTHPHRRRRLLRSKPEAESETRREVEGDTRGRGEAYGAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBA4</accession>
    <name>A0A132BBA4_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064013.1">
        <property type="nucleotide sequence ID" value="XM_018220624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBA4"/>
    <dbReference type="GeneID" id="28830350"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740737"/>
    <dbReference type="InParanoid" id="A0A132BBA4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="124" mass="14195" checksum="CADF901BC1110D13" modified="2016-05-11" version="1">MEPHQQISAQPSFNDFQQGRAGRGNGARARRYDVEDIPKFHSPPRNRGRAPSPQTFMPPQFGPKSPLRAPDSHNKSMPSVPRQEDINDWDDVYYEGHEFQIATRPIRILRLLEAETPPSGDEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBJ5</accession>
    <name>A0A132BBJ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690098</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063998.1">
        <property type="nucleotide sequence ID" value="XM_018216030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBJ5"/>
    <dbReference type="GeneID" id="28825756"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690098"/>
    <dbReference type="InParanoid" id="A0A132BBJ5"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288059" evidence="1">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="127" mass="13212" checksum="883F194880FDB6A2" modified="2016-05-11" version="1">MRSTIAIALSFLTAAVSAAPTVRSASTVEVQFSNVVTGANGNAWIPLDGSAVVLGEAYADTDLEVNGTLFVTSLEFTADFQNVACTVLKTATNTVVASIADPAQDFQTFSEKPLNWQAGFTISCTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC79</accession>
    <name>A0A132BC79_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_760853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064387.1">
        <property type="nucleotide sequence ID" value="XM_018221524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC79"/>
    <dbReference type="GeneID" id="28831250"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760853"/>
    <dbReference type="InParanoid" id="A0A132BC79"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="591" mass="66532" checksum="48C93FE427D03F41" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BC86</accession>
    <name>A0A132BC86_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_268278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064380.1">
        <property type="nucleotide sequence ID" value="XM_018206337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BC86"/>
    <dbReference type="GeneID" id="28816063"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_268278"/>
    <dbReference type="InParanoid" id="A0A132BC86"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="30371" checksum="366FC0AF7B36D63A" modified="2016-05-11" version="1">MPPQSTTWNFKCGHSFLEATIPEGDHENTVTSYKVCPRCEETISAEQHAKEVAMSEDEYALHIHEKHHDFLQKAGEKVDDGSDLDYYFTLTSQANDVEWAKQIIKIGYQFAFSHQPRIGTVAEDLEVKAKKLRVLVNAEDVNFEKLPTGNGKKAKQVKNEWRIRYVKVTEAKKLFDGLLMGYSEEDINMSLSLESEVRSVWAGVLGVYDPEEDELNKWLGQTGVEEEPARVSYLDEEWLSGVEEELGQISDEDEITDNRDSIKFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BD62</accession>
    <name>A0A132BD62_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative vitamin H transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_675766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063952.1">
        <property type="nucleotide sequence ID" value="XM_018213535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BD62"/>
    <dbReference type="GeneID" id="28823261"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675766"/>
    <dbReference type="InParanoid" id="A0A132BD62"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ09597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="495" mass="54987" checksum="DE720B5336C17165" modified="2016-05-11" version="1">MEEKMPEPTDIQLDEKLPPQIVVVDDEEKLILRKIDVHLMPFMFVTYMLQYLDKITLGYTAVMGIQADIHLVGQQYSWCSSAFYFGYLVASFPGSIGFVKFPLGKYLSTAILCWSIILMCHGAASNFTSLIILRVLLGVFESIISPGFSLITGLWYKPSEHSLRHGIWFAGNGQASIFGGVLGYAIGEIRSPLAAWRWLFIIFGLITFVWSMVLMIFMPDSALNARWLTPHEREIAHSRPQKQSRSFKSTHWKPSQALEAIMDPKTWLLFFYTALTSLPNGGVTNFTSVIIKGLGYGELRTLQLGMPQGACQVVFTLTAAYLATKLRRSRCIIIACLLCIATLGWCLVGYLPASHKSGRLGGVCIFAAYASGFPLSLSIIASDVAGYTKKTVVSAILFLAYCAGNISGPQVFFAREAPHYQTGCKVCIICLCLGIVDILVLRQYMDWENKRRDKAQGVKIEAEPGRLSGEIGVVELPSAGLDETDWEQEGFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEU8</accession>
    <name>A0A132BEU8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_259688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064739.1">
        <property type="nucleotide sequence ID" value="XM_018206264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEU8"/>
    <dbReference type="GeneID" id="28815990"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_259688"/>
    <dbReference type="InParanoid" id="A0A132BEU8"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="484" mass="56028" checksum="6D3EB5168DD3591D" modified="2016-05-11" version="1">MLQFLTNLTATTSSCLIFRALCSGRPANFIELAFSKVPHLHLEEHTWQDIEDFLHTNIRTVTDHLPPDERRDRIIAEIVPEVVGKSEGVFMWASVVVEDLLTLIAAGREEELYEKIKELPPELESLYASIIAKIPPRSRHHTYNYLQLQVSAGHGENAPHNLLGIMLASFPPEQVRTAPSNIDRWSDDAKIVACHRTRRMLRDNCSGFVKLPHFNPSWSKEEQVNRFCCGEVYVHKSVKDYLFNKESFKKVWSGIDQKLLIHSHLQRVSFCFHLLKVDFVTRYQAVPRIWRNEDSVLVAVPKLFLKAVSVGEVDEKLDLSVTWLLALENLVRTKASSLTEIVDFYDATFVLEYRNFERCTNDPPFEAWNTNMLCLAVSYGLIPYIKAYVHRNLHLRKGRPLLHYLFGAYVELSYDTFEPVAKILHRHGSRFDQVFNGRTTWEYILIHMQFGVYINSWERDGYDKILILCLEQGANPNQKINLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT45</accession>
    <name>A0A194WT45_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_739337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065485.1">
        <property type="nucleotide sequence ID" value="XM_018220455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT45"/>
    <dbReference type="FunCoup" id="A0A194WT45">
        <property type="interactions" value="1060"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WT45"/>
    <dbReference type="GeneID" id="28830181"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739337"/>
    <dbReference type="InParanoid" id="A0A194WT45"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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            <dbReference type="Pfam" id="PF11500"/>
        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="28"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="146" mass="15837" checksum="EBBE6B905B68DBDD" modified="2016-10-05" version="1">MDAKSSSNSSVRYEDYADIEAPPSYNDTISSFPVSSTSSSPSAYYSSQISSQLQTLTTQISSLESQKSLLAHAQDEKILSCLTTHIQTYLSDFASTGLRRGTLILVPASGLKSTNAVPTDYDFKDPEEYDRVVRMRGKEDGSGDGS</sequence>
</entry>
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    <accession>A0A194WWU6</accession>
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        <lineage>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0031177">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
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        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="530"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113985" checksum="8EDF3A9385F21DDB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXC9</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_721986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXC9"/>
    <dbReference type="GeneID" id="28828416"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721986"/>
    <dbReference type="InParanoid" id="A0A194WXC9"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267560" evidence="2">
        <location>
            <begin position="19"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="546" mass="60860" checksum="95BDB557E9BA2B45" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXE9</accession>
    <name>A0A194WXE9_MOLSC</name>
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            <fullName evidence="3">chitinase</fullName>
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    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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    <dbReference type="FunCoup" id="A0A194WXE9">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WXE9"/>
    <dbReference type="GeneID" id="28825404"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688281"/>
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    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
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    <dbReference type="InterPro" id="IPR017853">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
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    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
    <sequence length="380" mass="42243" checksum="67CE8A817AF9F587" modified="2016-10-05" version="1">MTDRNRFIPDLEAAIRMSLDGVTDKAPADIARGSILDLMILKQKNRGLKTLLSIGGWTFAHENKVFDVPAHSAEGRAEFAISTVELVKDLGFDGIDIDWEYPQNEEQAKDFVLLLKEVRVALDAYAEKSALGYHFLITIACPAGATEYGIMHLKEMDQYLDSWHLMGYDYSGAWSPVTSHGSNVYKDKVHADNTQYSTHDAVQAYIAAGVPAQKIVMGMPLYGRTFQQTDGLGSKHGGVSDAADYRDLPKPGAVEHFDPDTVATYSYNEATRELTTYQGKDETRVKAEYLKTNELGGAMFWQAFQDKQGDDSLVHTVRKSMGSLEDSRNLLHYPESQYSNIKNVQPVQESVQQTESGQRQEHLNAAGSALAVIGHWLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXP4</accession>
    <name>A0A194WXP4_MOLSC</name>
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        </submittedName>
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXP4"/>
    <dbReference type="STRING" id="149040.A0A194WXP4"/>
    <dbReference type="GeneID" id="28832642"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785739"/>
    <dbReference type="InParanoid" id="A0A194WXP4"/>
    <dbReference type="OrthoDB" id="5006988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="140" mass="14881" checksum="5CC665305C132C94" modified="2016-10-05" version="1">MSLTAATSLAERGISTSAKIGKRGQTWCGCRNGMDHSTCDQANDDLRNQLGSGPNINGGQAYYSIKSPSVAFVCNKDQYSAQVFGGSVPTGSQHVTQACGLYVAGTWRIDGLPAMDYRYMDWNNGLDFCAHAEGSGSHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY88</accession>
    <name>A0A194WY88_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_211728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067004.1">
        <property type="nucleotide sequence ID" value="XM_018205876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY88"/>
    <dbReference type="GeneID" id="28815602"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_211728"/>
    <dbReference type="InParanoid" id="A0A194WY88"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="266" mass="30815" checksum="C2E9DCFC65541E09" modified="2016-10-05" version="1">MGNGCSKPSAVFQKFPEFPLDIQLLVWEHAIQGIPARVVALRRGTELNDIPALLHTCHDSRTLALQRYEWTENKKGHGRRAYPPRMRSYFCFIDYELDSVYLPPLKYSLKSSPSLISSSAYGTHLRNLRTIIILWKFSVPWQSLLKPTKIAKFCPNLRKLIIVKPGYRGPGGRFLELVASEPLQDILEIYGGVCVQRCHLKRWHSAALKCSVNCTKSFEKLEVQELHFKMYLNVQECKRYLWQKGLESRFEIVPKQNSFKTGFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYC9</accession>
    <name>A0A194WYC9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_756189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067300.1">
        <property type="nucleotide sequence ID" value="XM_018221367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYC9"/>
    <dbReference type="GeneID" id="28831093"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_756189"/>
    <dbReference type="InParanoid" id="A0A194WYC9"/>
    <dbReference type="OrthoDB" id="3531154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="49382" checksum="EB2662B718338B5A" modified="2016-10-05" version="1">MLSTRQFFTSKPFPWPCAVEQAPFTNYLTGISLRQTDLSRSKIRDCAITDCSITGHTLAPIILEDCLIENSNIDACELINCVIKDSKVNESDMKRCTIYQNSRVTQSTMDQSLMLNSSAQRVHCENSYFYESELIKCKMVVCKLNNTHAVGIEAKSSLLRFCNIAGSRAKFTRSTLDDCKVCAKDSTVVESRTLSHPLALYKFPPEIRNLIYEYAIDGKGRGSPLIAALRGEPKLYHEALAVLNRTCVFDADKDILRKASSVLRTARPDEHADVLGQVRHTIIGADLLFVLATITFVLNEYKVLESIHINEWDYMQHGRANEDGHSDLLRFCKKLFRAKNLSMKKLTITFGSVLDLPFKTDTRDALMKAVNRDLENMLGVQGKKMQTEGASDEFTPKTTWTWTATPGTKLWLAMEDVDSTFKKFAESESESNAMDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYD7</accession>
    <name>A0A194WYD7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_623821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066977.1">
        <property type="nucleotide sequence ID" value="XM_018211034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYD7"/>
    <dbReference type="GeneID" id="28820760"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_623821"/>
    <dbReference type="InParanoid" id="A0A194WYD7"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="42477" checksum="B50507AC8E146E1C" modified="2016-10-05" version="1">MGWTYNVVDPNVATNAPTVAGVGITFTILSFSIVCLRLYVRKYIVKAINIDDWLIVVTWFFSFIFVCITLAQTRWGLGLRNVEDMPPQDVYEFGYLQYIGAPFYICAILGFKLSIIFAFLRIAVDRTYRIGIICISITCSAFYFCFFVAQLNFCFPVSKSWDPTITTGSCFSAVLFYTAMGSLTFIFDILTMLTPIPILLHSCFSPCKNFMIAFLYLLGIFLSLIQILRITSLRSARSYLDTSTVLTWSLVEVNLGIILSSLIPLAPLPVLQSFLEKGSPQSLAQSLASFDTRRTIDKVRDGFKKRFGRESELRNRVVLFLGYGELRPDLEREQRPGSRLGASTEELNFPMGILKTTEVIISREGSSWGELKEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYI1</accession>
    <name>A0A194WYI1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067373.1">
        <property type="nucleotide sequence ID" value="XM_018215605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYI1"/>
    <dbReference type="GeneID" id="28825331"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687908"/>
    <dbReference type="InParanoid" id="A0A194WYI1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267695" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21066" checksum="D0F00F72E720D6F0" modified="2016-10-05" version="1">MLCCLTSAAVSAILSPFGLSVVSASRAHSLVSFHLALDFLFHYLDENSSPCVHAKKLQETSANHSYRVSRMEFFCIVWKEWQAAVSSVHWSLPCRLRNLLHANQRKKSFQAFLGIAYQPCMLTVPGMHVEKASKRMRHIILQSNGWLHRGAALETEFFVSNVGERDARELIREHRRMGVTAGCRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZK8</accession>
    <name>A0A194WZK8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_199713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067402.1">
        <property type="nucleotide sequence ID" value="XM_018205778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZK8"/>
    <dbReference type="STRING" id="149040.A0A194WZK8"/>
    <dbReference type="GeneID" id="28815504"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_199713"/>
    <dbReference type="InParanoid" id="A0A194WZK8"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_1"/>
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    </dbReference>
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        <source>
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            <dbReference type="EMBL" id="KUJ13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="479" mass="53802" checksum="8C4D631C4992B295" modified="2016-10-05" version="1">MTTKVLPKDFLWGFATAAYQIEGAPEADGRGPSIWDKFCAIPGKIADGSSGAVACDSYHRTGEDIALLKETGAKAYRFSIAWSRIIPLGGRDDPVNPAGIAFYKTFVDDLLKEGIVPMVTLFHWDLPQELDERYGGLLNKEEFVKDFANYAKVMFEALPKVKHWITFNEPWCSSILGYNTGLFAPGHTIDRKKSPVGDSSKECWIVGHNFLLAHGTAVKIYREEFKPKNGGEIGITLNGDAVYPWDTEDPLDVEAAERKLEFSIAWFADPIYHGRYPASMTAQLGSRLPSWTPEEIALVQGSNDFYGMNTYTANYIKHKTGTPPADDFLGNLETLFENKAGECIGPETQSFWLRPNPQGFRNLLNWISKRYNQPKIYVTENGTSLKGENDLPLEQIVDDEFRAEYYRGYVGALAKAVGEDGVNVRAYMAWSLMDNFEWAEGYETRFGVTFVDYEGGQKRYLKKSAKVVGPLFDSYTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZP0</accession>
    <name>A0A194WZP0_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_737977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220318.1"/>
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    <dbReference type="GeneID" id="28830044"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737977"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="456" mass="51851" checksum="159F24153819E71C" modified="2016-10-05" version="1">MASVSQAQGELKSSDTHVSGQSTVDTSNTGSGNAATTPSQTLPQLSPVPSYPTAPTQMTHYQQFPTAPQNYLLRYPTRSHLAPRLPPLKRPFTPMTSRLNHTQVHVLALSFENHGLAETHRQEINKLLDTFQYRYNYTVTDFRIPENGSQVDSENAICKEIMSYKNGSANFGPSLLWVYYGGHGGHGGFSGGEFCLEGDTVPGTDMNIVRWAPIRNALASLYCDVIVVIDSCESGAAYDPNLELRPNGYRMDLLAACGTDKTTKGPGDFSFTKSIDDNLNQMADGDYRISLHDLTTALRNRRDFVAWALVYHAPNWWNLPRWNTETQPELVHRNMRDDGYSTIHLNVYASQSLYPGQSATVSGGFKSLAQSEMEMEREVMRRVQFVFFDEKGTLFNDRQEYEDYQKQLQEEDERWEAEEKELDEEERRMEKEMENDKLRRRDEDEARKKYNGGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X036</accession>
    <name>A0A194X036_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_737531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018220269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X036"/>
    <dbReference type="GeneID" id="28829995"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_737531"/>
    <dbReference type="InParanoid" id="A0A194X036"/>
    <dbReference type="OrthoDB" id="5303703at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="758"/>
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        </location>
    </feature>
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        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="866" mass="96127" checksum="AE8F5ABC31E06AFF" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X053</accession>
    <name>A0A194X053_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_160211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067930.1">
        <property type="nucleotide sequence ID" value="XM_018205493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X053"/>
    <dbReference type="GeneID" id="28815219"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_160211"/>
    <dbReference type="InParanoid" id="A0A194X053"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="51072" checksum="9D7B574A124EC9C3" modified="2016-10-05" version="1">MPIIDNTPVSPYQDYVSGLVPNKHGYLAELLQLQRSGPQPTSNDEPVFVNEFQVLDIVDGKFACQVFRPELVGPVDQQFTRLLEEHPEGLKSRFLIFRHNSILRQQRTAPRLEINGNYLNAISSRFELDPSFLEKHFALCELHQNKTIPRLVPVPLPKDGSCLQIMCNSACHFTMCRTKADGHKIVVIFGFHYYEETEDIPDLTNGPFQSATTGKISIEDVLAIQEQPLHLLYNTILDALLEFGMICFRAEWDPRANELTAEKLLERRQRLRTEHLALAATRRSLGMFSDKSRINHGASDAKWRTLTDNLTALLETSDKINTELKDHLQSTHSIDAIEEARRGLRQNETLKRLTIVAFIFIPVNLSCAFFSMNVKQLNNSSMDIGYFFLGILVSGFLAWALAAAISSTFRALARARAEISKDGRKPVSPNGGRSEPLEKNRVADEVPVSWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0W9</accession>
    <name>A0A194X0W9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_736839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068198.1">
        <property type="nucleotide sequence ID" value="XM_018220178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0W9"/>
    <dbReference type="GeneID" id="28829904"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736839"/>
    <dbReference type="InParanoid" id="A0A194X0W9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267771" evidence="1">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="215" mass="22981" checksum="19C11BC959E49AE1" modified="2016-10-05" version="1">MRLLSTLNLFLGLCASSVLANSLSTTSNLIKDDSLEITDQQVRSHTRDFAPLKLRDLELLSITSDALESRTPDTNTDDEALRRVRVEQDKVGTGNADGIEALVDGCAVVFAWAAGNVYCAHISENHEATTVAALGKLIGSKKIEAITLDWPKDASGEDPDGEAMLKRIETAIEKFNTGTGKVTPKVTPYSWAPMSAGQTFIATPKDVGVSTESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Z4</accession>
    <name>A0A194X0Z4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_736860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068218.1">
        <property type="nucleotide sequence ID" value="XM_018220183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Z4"/>
    <dbReference type="GeneID" id="28829909"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736860"/>
    <dbReference type="InParanoid" id="A0A194X0Z4"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="85" mass="8847" checksum="96FCA2318F45DC27" modified="2016-10-05" version="1">MTVWGYPVLLDWALGMTLITLVTVAQLSTLPKLIAFVSGLIISVRSLGETISIAVYNAVFTTATLHMGDNVGKAAAEAGLPTASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2R5</accession>
    <name>A0A194X2R5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_686799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068669.1">
        <property type="nucleotide sequence ID" value="XM_018215363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2R5"/>
    <dbReference type="GeneID" id="28825089"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686799"/>
    <dbReference type="InParanoid" id="A0A194X2R5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="54" mass="6228" checksum="E5831825AE1F3AF2" modified="2016-10-05" version="1">MTLVLRPHATDRIRLCLCLWPLPLPLPLVLLGCLRTKSSRRGYVMKLRASWAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4C7</accession>
    <name>A0A194X4C7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_686599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069388.1">
        <property type="nucleotide sequence ID" value="XM_018215321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4C7"/>
    <dbReference type="GeneID" id="28825047"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686599"/>
    <dbReference type="InParanoid" id="A0A194X4C7"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="73" mass="8141" checksum="36D1E68EA1A03A0F" modified="2016-10-05" version="1">MHSLYNFNPAYLHGLCVKAESGPKDTFDRITTAALVILGAAKMFIHIWRLFNRSKRPGESPHGESPVRSSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4E3</accession>
    <name>A0A194X4E3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_649679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ15050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069405.1">
        <property type="nucleotide sequence ID" value="XM_018212076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4E3"/>
    <dbReference type="STRING" id="149040.A0A194X4E3"/>
    <dbReference type="GeneID" id="28821802"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_649679"/>
    <dbReference type="InParanoid" id="A0A194X4E3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="279" mass="30226" checksum="C9AAC4D25DD1D7B3" modified="2016-10-05" version="1">MTTLRLREQDLEGKVAVITGATRGIGRAIAMNLASRGASILGTCSHASSLDLIANMRDEIDALYKEANQERTCRTTGLAANITSPTCAEDIVKKILDLRYGVDIFVNNAADSLPGGIGDLTVNEIQKSMISNIQTPVLIVDEFVKRKMFRPESRIIYISSIRSRQPWSEQLMYAAGKSAGESLCRTWSMAFGGNEEKFSFMAGTTANSVSVGLTQTDSVMQCPPDALEKFKQEFIPLQSIPRFGQPDDVADVVGMLCSRDTRWITGCVLSASGGGIKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4H9</accession>
    <name>A0A194X4H9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_569883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069324.1">
        <property type="nucleotide sequence ID" value="XM_018208581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4H9"/>
    <dbReference type="GeneID" id="28818307"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_569883"/>
    <dbReference type="InParanoid" id="A0A194X4H9"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="333" mass="38390" checksum="31782D6937085014" modified="2016-10-05" version="1" fragment="single">LRQCVADHSSCGTRNHGVKLPSRLLELHSNAIRLREACEVSRNMKYATLSHCWGPRGVEAKLTKELLEDFRANIRPESLPRTFQDAISITRRLGLAYLWIDSLCIIQDDPVDWEKESISMSEVYGNSWVNIAASWAKDCSEGCLYRSNPKIDRFQVEVKAWQDRQVRLQTLEVIPANMVLNSISMSVLSDRGWVLQERLLSPRTLHFTKAQIFWECNTLLGCESFPNGVPACTTVSDIHIVKNNLSEQWHRIITKYTRCNLTQRRDVLVAMSGIIKRLQEQRQDICVAGIWRQDPEMQLLWMRSPSDVQKARYLYTAPTWSWASSQGPIQQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5S4</accession>
    <name>A0A194X5S4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_686260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069883.1">
        <property type="nucleotide sequence ID" value="XM_018215244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5S4"/>
    <dbReference type="STRING" id="149040.A0A194X5S4"/>
    <dbReference type="GeneID" id="28824970"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686260"/>
    <dbReference type="InParanoid" id="A0A194X5S4"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ15528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="37393" checksum="C502D2EDD101A499" modified="2016-10-05" version="1">MASNHYKTLNEHYPWTANPTVVLAPMRMISTPPLATEVSRAGGFGFLGVGTDVSTFSPMLKEASSILESSLPTSEGVLPIGVGFICWGVDLSVAISVFESAPLKPAAAWLFAPREPKDLISWTEGIRKATNSRTKIWIQVGTVTMALDVVKSCNPDVLVIQGADAGGHGLAQSSSIISLLPECGDALAKEGFGHIPLIAAGGIIDGRGVSAALTLGASAVCMGTRFLAAPETPISNGYKNAVVKASDGGVTTARTTVYDKIRGTIGWPATYNARGVLNQSFWDHGKGMSEEENKRLYEEEMKKGDAGWSDQGRMTTYAGTGVGLVRNTQPAGEIVKEVMRDAKERLKTVGNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X626</accession>
    <name>A0A194X626_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_697744</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="5"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069990.1">
        <property type="nucleotide sequence ID" value="XM_018216928.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X626"/>
    <dbReference type="GeneID" id="28826654"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697744"/>
    <dbReference type="InParanoid" id="A0A194X626"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="666"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="706"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="853"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="911"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="17">
        <location>
            <begin position="1000"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="411"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="529"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="618"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ15635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149562" checksum="DA2D579A185F9DDD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X657</accession>
    <name>A0A194X657_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_587490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070018.1">
        <property type="nucleotide sequence ID" value="XM_018209434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X657"/>
    <dbReference type="STRING" id="149040.A0A194X657"/>
    <dbReference type="GeneID" id="28819160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_587490"/>
    <dbReference type="InParanoid" id="A0A194X657"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10331" checksum="4A83A109E3F8BE54" modified="2016-10-05" version="1" fragment="single">TGDITYYEAGLGACGWTSDGSTEQVVALPYELMGTQSNGNPYCGKTITISYQGKTTQAKVVDKCMGCMGDSIDLSNAAFLELAELAVGRASAEWWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X676</accession>
    <name>A0A194X676_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fe-S cluster assembly protein dre2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_697776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070035.1">
        <property type="nucleotide sequence ID" value="XM_018216930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X676"/>
    <dbReference type="STRING" id="149040.A0A194X676"/>
    <dbReference type="GeneID" id="28826656"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_697776"/>
    <dbReference type="InParanoid" id="A0A194X676"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11000:FF:000002">
        <property type="entry name" value="Fe-S cluster assembly protein DRE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="241"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="343" mass="36725" checksum="8D7CC2300F55157F" modified="2016-10-05" version="1">MAPAIMIDNEADFNPVVSTTKPSSSSSLRTLLLAPPSISSHEENLRNILASHDRSVTDLQMLDRLSAGLVTLPDSAYDLVLILTDADGTRTESTQLLSRNVFDRVVKALKGWGKLQTQDGTLGQDRHNGAEIHELILAGLVADGTSWVKPDYGVHGFVSLRSKGKGAVSDAGPPVATTTVQVNGKRKSVDMTGTKPAGVGFVDFGDDFGEPIITGEDDDDDELIDEDTLLTEEDLKRPANVPPECVPRVGKRRRACKDCTCGLAQKLEAEDAAKREAADAQLKTLKLDSDDLAEVDFTVKGKVGSCGNCSLGDAFRCDGCPYIGMPAFKPGEEVRLLSNDVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6C4</accession>
    <name>A0A194X6C4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_647438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069974.1">
        <property type="nucleotide sequence ID" value="XM_018211958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6C4"/>
    <dbReference type="FunCoup" id="A0A194X6C4">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X6C4"/>
    <dbReference type="GeneID" id="28821684"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_647438"/>
    <dbReference type="InParanoid" id="A0A194X6C4"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ15619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="194" mass="22104" checksum="748EB58B343D9EBD" modified="2016-10-05" version="1">MAGSHMRYRHLSRKSSHRQALLRNLVTSLFEHESISTTWHKAKEAQRLAEKLVTLGKKNTEASRRKALGIFYKPHDLVPKLFGPLRERYADRPGGYTRVLRVESLKPDQAPSAILELVDGPKDMRFAMTARTIAKDRAEGQESTEMTDRNVEKVTRYRPDGEKDLESMVAKLSNLKVGDRSNASTDERRWGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X709</accession>
    <name>A0A194X709_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_735102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070315.1">
        <property type="nucleotide sequence ID" value="XM_018219977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X709"/>
    <dbReference type="STRING" id="149040.A0A194X709"/>
    <dbReference type="GeneID" id="28829703"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_735102"/>
    <dbReference type="InParanoid" id="A0A194X709"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="187"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ15960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123756" checksum="3B50D97E0E89D8A1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X796</accession>
    <name>A0A194X796_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_708059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070396.1">
        <property type="nucleotide sequence ID" value="XM_018217657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X796"/>
    <dbReference type="STRING" id="149040.A0A194X796"/>
    <dbReference type="GeneID" id="28827383"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708059"/>
    <dbReference type="InParanoid" id="A0A194X796"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="50750" checksum="C675229F4447922F" modified="2016-10-05" version="1">MSSFQHLLGKHLTSTPLNTGEVVAKVAEASVEDVDTAVSAALAAFPSWSSLSPIQRGKPLKKMAEKILSSTPELAELDAISMGRPVSSFFDADYAAVHFNYFGEAAYAQGHTSLNTPGFINMSLRQPFGVVGIIIPWNAPLVFFSKKVAPAVAAGNCVVLKSSEKAPLTSWKVSQWIKECGFPPGVINVLSGHGHISGSAISSHMSIRAISFTGSTRTGRAIQIASANSNLKKVVFELGGKGPALIFDDADLEQAAKDTENSIFWNSGQTCMANSRIYVQDTATEKFVEVFKKLASARKMGDPTKGEINHGPQADKVQFEAVNKYIDAGKESGGKLALGGEEAKTNGETKSLLIHPTIFLNADESSRIMKEVIFGPVVVINTFSTEAEVIAKANHTEFGLYACLYTKDLERALRVSKKLESGMVGVNCAAPTGCWDLPFGGWKGSGTGRESLLESMDHFLEVRSIYFKCPGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8J3</accession>
    <name>A0A194X8J3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_84502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070841.1">
        <property type="nucleotide sequence ID" value="XM_018223454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8J3"/>
    <dbReference type="FunCoup" id="A0A194X8J3">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X8J3"/>
    <dbReference type="GeneID" id="28833180"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_84502"/>
    <dbReference type="InParanoid" id="A0A194X8J3"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="176"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="267" mass="29397" checksum="6A50A2121C0F98C5" modified="2016-10-05" version="1">MAPKIITWAPLDIFSPAPIHHKPLAIIILNQELKLPLYLYHQLWLNSTFVIAADGGANRLYDLNKAHSTTLSTNAIIGDLDSLLPSVRSFWEDRGIPIMHDSDQYSTDFTKAVNYIRASPSRKDIDIVVLGGLGGRVDQGLSVLHHLYLFQDSVTYEDGRMYLLSSEAVTFVLKKGKHGIKAKERWEGIGSGEGKGEVGLGKHVGILPLKGESVISTQGLEWDVKDWKTVFGGLVSTSNHVKEETVKVETDEDVLFTIDLNFAGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X900</accession>
    <name>A0A194X900_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071001.1">
        <property type="nucleotide sequence ID" value="XM_018219938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X900"/>
    <dbReference type="STRING" id="149040.A0A194X900"/>
    <dbReference type="GeneID" id="28829664"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734740"/>
    <dbReference type="InParanoid" id="A0A194X900"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="69" mass="7587" checksum="4F35A42DDD4405C3" modified="2016-10-05" version="1">MVRHIVNCKTKADVEPAKKLVEEQGGKIVDTYTLIPAFVVDMPKDSVSAFESSPHIETVELDSEVKTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X970</accession>
    <name>A0A194X970_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_781965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071024.1">
        <property type="nucleotide sequence ID" value="XM_018222532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X970"/>
    <dbReference type="GeneID" id="28832258"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781965"/>
    <dbReference type="InParanoid" id="A0A194X970"/>
    <dbReference type="OrthoDB" id="5429287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="708" mass="79046" checksum="6432782E4F4E6258" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9R3</accession>
    <name>A0A194X9R3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_617769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070867.1">
        <property type="nucleotide sequence ID" value="XM_018210812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9R3"/>
    <dbReference type="STRING" id="149040.A0A194X9R3"/>
    <dbReference type="GeneID" id="28820538"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_617769"/>
    <dbReference type="InParanoid" id="A0A194X9R3"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268005" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="12">
        <location>
            <begin position="358"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="444" mass="48925" checksum="3220F226B15388E5" modified="2016-10-05" version="1">MMFISITLAIWLAISQVQCLVQKDDVGKLPALGWNSWNAFACDINETKLLTAANQIVSLGLKDSGYEYVNIDDCWAVKSGRDNKTGQIIPDPIKFPSGIDGLAKSIHSLGLKIGIYGSAGTETCAGYPAQLGHEYLDAATFAAWGIDYFKYDNCYVPSNWTDPYDACVPDQWQKYGPFVNGTCAKSSTDAPTGYNWSTSNTAHRYAIMRDALLAQNRTILYSLCEWGQADVVTWGNATGNSWRMSGDINPWWARVAEILNENTFLLNSVNFWGHNDMDMLEIGNGNLTLAESRSHFAFWAAMKSPLIIGTALDVLPATHVAILRNKYLLAFHQDPLFGAPATPYKWGTNPDWTFNATNPAEYWSGESSQGTLVLALNTLGTKAPKTIVWKEVPHLEKEHDAFQVTDIWSGESLGCVSKGIEIKVEAHDTVGYIVGEKCAPMFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9U3</accession>
    <name>A0A194X9U3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_707347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071293.1">
        <property type="nucleotide sequence ID" value="XM_018217599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9U3"/>
    <dbReference type="GeneID" id="28827325"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707347"/>
    <dbReference type="InParanoid" id="A0A194X9U3"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268043" evidence="2">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="474" mass="52916" checksum="9F8EE9D43765CE2D" modified="2016-10-05" version="1">MARSFVILLFPSLTYAYTTFETNCSIPTNSTNFVSSNGTRGTMDILWSCLFTIITCTWIVQHLNVPEQREDRNPGIWGTIWWAIKRGWTSAKWMLVTVLAPEILLAKNVGDLTTVKLDLEKLQDWAAQDGVPWTRTHSLFANMGGFVIRRSSPKRAQNPTESKEPSTAELGLSANASQPVLIHLLTQDIVLLRSKGLLPKLPYITLEEINDKSKSDSLIRAIIVVQIIWMVIQIIARAFRSLAISQLEVSVVAFATCAIILYGINWEKPKGVQVPITIISYPGPFPKDTMEIVERDRNGADISVFSGLMFLVEKLFTCLYDGESTVKWPLGKPIPNVYNRDDPWVNRIMGESVLSQSDIFGLFLGTAVFGAVHIAAWNFVFPTPVESLLWKIAAILCTTMGLVFGGYMVTLSTFSDIESLGYIYKIALAILFFLIPASYVVCRLFLVVEIFRSLCFLPPSAYIATWATNVPHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAH2</accession>
    <name>A0A194XAH2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_685099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071520.1">
        <property type="nucleotide sequence ID" value="XM_018215017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAH2"/>
    <dbReference type="GeneID" id="28824743"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685099"/>
    <dbReference type="InParanoid" id="A0A194XAH2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="506" mass="55250" checksum="816E9F6DCA3AF1DC" modified="2016-10-05" version="1">MASVEKMNDAEYPVDSKEAPGSESDIERGNGLVQVASNYVVDRKLEKKMLFKFDIHILPMLAIMYLFNSIDKSNLGNAKTDGLTKDLHFTGNQYNILLSIFYVPLVLTAVPMNMLTKKFGAKFVLPIAMIIFGSMAMISAGTTNFGGIVTTRWFLGMAESGFYPGVIFYLTTFYKRNELAGRLSIFYAASEVAGAFTGLIAFGVFQIKDALYGWQYLFIIEGGLTVLGGIIAIIVLPKSAATAYFLNEDEKALAYHRIAANSSTVVDSEFSFRQAIRVFKQDRLWPVYMSIGFCVGVPLFSVSNFLPQIVAQLGYSTVKTNLYTVAPNIVGACFVVFVAFSSDYWGDRSCHLAATLATTAVGFVVLACVDVPNHLGVGYFACFLLCAGGFITSPLLSTWYNNNTPDENQRAILTPVMVCTANAMGLVAANIFTEQSAPRYVMASIICACFGFAGVAIVLSLGFWMKYDNARRNRAQGVNTKAGDVPTSELKGGQKDPSWRWMGGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAK0</accession>
    <name>A0A194XAK0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_64100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071142.1">
        <property type="nucleotide sequence ID" value="XM_018211695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAK0"/>
    <dbReference type="GeneID" id="28821421"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_64100"/>
    <dbReference type="InParanoid" id="A0A194XAK0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="168" mass="19057" checksum="2B4612A662167136" modified="2016-10-05" version="1">MMSIERLASCLRIKQRELEFCPQPQPQPQPSNASRDPPLVLTPHRQKEQGKARASKRRLKPTSSFSHNSGITAHVLLTFPSLLPLVYSLSVGLSAGRNENFTLINCLLVVWFIHSFVPLHSFNHTITQSHNHTITQSHNHTITHHIYPPARIRITSSYAFDTLERIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAX2</accession>
    <name>A0A194XAX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_50810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071670.1">
        <property type="nucleotide sequence ID" value="XM_018208051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAX2"/>
    <dbReference type="GeneID" id="28817777"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_50810"/>
    <dbReference type="InParanoid" id="A0A194XAX2"/>
    <dbReference type="OrthoDB" id="4838114at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="494" mass="53555" checksum="C422392519CABA39" modified="2016-10-05" version="1">MPLLTKMLPLRETVEDFQAASLHSSHQQHQDEGQEKDKDSGYEDFQEFDEEDECLDSDMEGSIIHRGRPKKAVRAPAIPARNERRASKILENVMLELQTLDGKEAKDTDSRSMVPESDPHESYLSSEEDASLSDDYDDLESLSGTASPSAEDADNEEGRESFSRGSRRKSQEDTARVVSFICVGKPQIVDIFISSNHASPIERGNGSIPKRHSMNLEALTALTQTQSSSPAKSSRRPTPLKLYPNSIRRMSISSITSSHTSNSSYNQPAPTNASNTNLSSLPPRKSSRLALNINSLITSTKTTLQKSVSASAAVPSHSFLTSDPFSTTASNEDTQPTTPKTPTSIAAAAWKRGLSKTLTKARKPSMPKLYTAYTNSSSASISPDKKRISTAHSNLSSNNLARIISESIPDAETRSRSSVYSSASSQRDPAVEPVVEVKRSSTMPVLTSPTTSTSYIPPVVQKPPPIPASTTPVSAGGRRSFSLGLGRKKSVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB13</accession>
    <name>A0A194XB13_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_51268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071689.1">
        <property type="nucleotide sequence ID" value="XM_018208077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB13"/>
    <dbReference type="GeneID" id="28817803"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_51268"/>
    <dbReference type="InParanoid" id="A0A194XB13"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13150" checksum="FBFF036325ED395A" modified="2016-10-05" version="1">MLNGTQKSHPRPFNPLPDPKMPSIHFLVFALSPSISIVRLVSFVSDTAKRAKQPPPHDIAYDAASCHDQQGLAPFMIAFFTQSQLSHFTPTRRSLLGRALIDWVISTQFYRGTQNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBC0</accession>
    <name>A0A194XBC0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_584830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071825.1">
        <property type="nucleotide sequence ID" value="XM_018209293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBC0"/>
    <dbReference type="GeneID" id="28819019"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584830"/>
    <dbReference type="InParanoid" id="A0A194XBC0"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="212"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="439"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="67081" checksum="15027AB5F361E331" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDJ1</accession>
    <name>A0A194XDJ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_614870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072598.1">
        <property type="nucleotide sequence ID" value="XM_018210705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDJ1"/>
    <dbReference type="FunCoup" id="A0A194XDJ1">
        <property type="interactions" value="1351"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDJ1"/>
    <dbReference type="GeneID" id="28820431"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_614870"/>
    <dbReference type="InParanoid" id="A0A194XDJ1"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="23946" checksum="294201A08A28AA61" modified="2016-10-05" version="1">MGALKYVEELQKKKQSDVLRFLLRVRCWELRQLNVVHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQRSLKSTAEERVGRRCANLRVLNSYWINQDSTYKYFEVILVDPQHKAIRRDPRINWIVNPVHKHRESRGLTATGKKSRGLGKGHGYNKTTAGRRKTWKRHNTLNLQRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDK0</accession>
    <name>A0A194XDK0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_583116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072581.1">
        <property type="nucleotide sequence ID" value="XM_018209195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDK0"/>
    <dbReference type="FunCoup" id="A0A194XDK0">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDK0"/>
    <dbReference type="GeneID" id="28818921"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_583116"/>
    <dbReference type="InParanoid" id="A0A194XDK0"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="86" mass="9918" checksum="B3582FC3C54DB1A6" modified="2016-10-05" version="1">MSYFRITLMRSGIGLPKRTQGVLKALGLRQRMKTVFYPVTPEVAGQIMKVKELVAVREVDRALTKHELKAERKPDPGFYMERAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDW0</accession>
    <name>A0A194XDW0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_746635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072718.1">
        <property type="nucleotide sequence ID" value="XM_018221097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDW0"/>
    <dbReference type="STRING" id="149040.A0A194XDW0"/>
    <dbReference type="GeneID" id="28830823"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_746635"/>
    <dbReference type="InParanoid" id="A0A194XDW0"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="146"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="512" mass="58330" checksum="3570372E1D275D45" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDY1</accession>
    <name>A0A194XDY1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_706602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072312.1">
        <property type="nucleotide sequence ID" value="XM_018217539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDY1"/>
    <dbReference type="GeneID" id="28827265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_706602"/>
    <dbReference type="InParanoid" id="A0A194XDY1"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="322" mass="36632" checksum="639967A01AD62BD7" modified="2016-10-05" version="1">MNVRIDRHANATVWRPPEGEIPFDVPEAGKPCHTWYKVVGDLNVTSPSIVPLITLHGGPGVCHELLGPLADLNEQYGIPVIFYDQIGNGKSTHIREKAGDEAFWSVELFMRELDNLIDYLGIRDGFDLYGQSWGGLLASQYATLHPKGLRKMILANSPASVELVLKGEEALRAALPKEVRETIERCEREGTTDSEEYAKALEVYRKRHICRIDPFPEEMNIAMRHMKEDPTVVNTMWGGDKLKPTGSLKDWTIIKDIPKIEVETFVLHGRYDQVQDISVIPFFELLPRVRWVTLEKSSHLPFFEERERYMELLGGFCGGFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFN7</accession>
    <name>A0A194XFN7_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_780634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFN7"/>
    <dbReference type="GeneID" id="28832127"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780634"/>
    <dbReference type="InParanoid" id="A0A194XFN7"/>
    <dbReference type="OrthoDB" id="5389823at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="571" mass="64133" checksum="EF64FBD58F018066" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XG62</accession>
    <name>A0A194XG62_MOLSC</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_581070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073486.1">
        <property type="nucleotide sequence ID" value="XM_018209091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XG62"/>
    <dbReference type="STRING" id="149040.A0A194XG62"/>
    <dbReference type="GeneID" id="28818817"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581070"/>
    <dbReference type="InParanoid" id="A0A194XG62"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="14685" checksum="16047EAC26104734" modified="2016-10-05" version="1">MNFAHIEQAQQGGQNYHFEAPQSMDTTGQVAPIGMKPRVTATLWEDESTLCFQVDVKGTCVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKLKHVVKIGPMHLKGVWYLIPLLSPSPFLPLLNLTKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGD2</accession>
    <name>A0A194XGD2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_716779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073551.1">
        <property type="nucleotide sequence ID" value="XM_018218289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGD2"/>
    <dbReference type="GeneID" id="28828015"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716779"/>
    <dbReference type="InParanoid" id="A0A194XGD2"/>
    <dbReference type="OrthoDB" id="3439935at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="845" mass="89086" checksum="5AAAFAE3D78EE672" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGN0</accession>
    <name>A0A194XGN0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_612915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073651.1">
        <property type="nucleotide sequence ID" value="XM_018210645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGN0"/>
    <dbReference type="STRING" id="149040.A0A194XGN0"/>
    <dbReference type="GeneID" id="28820371"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_612915"/>
    <dbReference type="InParanoid" id="A0A194XGN0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="564" mass="64586" checksum="C7B24D07A59BA8F3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI76</accession>
    <name>A0A194XI76_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_491450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073822.1">
        <property type="nucleotide sequence ID" value="XM_018207900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI76"/>
    <dbReference type="GeneID" id="28817626"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_491450"/>
    <dbReference type="InParanoid" id="A0A194XI76"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="90"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ19467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55166" checksum="0E00D8B9C80D7C75" modified="2016-10-05" version="1">MMSNTDPVDPGTAAGPSPATEQKSGDDLWSEAVKLLRPGDEEQLRLEKADKLPVLEEVLAAAIKKRERCKDRQWRIKKRDGTVIVLRDVFDKIASWLKKLESIGDCVAQLDSVHLALPWSVIKFFLQLSTGDNEKLGSVYDQLEKITNLIGRYGIFEELYLEESSKASNLLKKAIVKLYASVLTFLAEAKRYYAQDTAKRMAKNILQISDWDVDKLADNIQSEQACVDEIARLIDAESLRNASQGIKRLSKGAREHKEELRKALGDLGIDHINDQLTVLTKDLASTKKRELLDWISKIPYSEHHESVRKGRLKGSGIWLFEQTQYEEWRKSTSSSLLWIHGIPGSGKSNLASLVIDTLRENRMNPQAEPLAYVYCARNANEPERADPSPIVRCLLRQLACPKPKMDIQDVVLRKHQELEEEGFEGVNPRDLSLIESKELILDLLESHRATIIIDAVDECIPGSRYQLLSTIKDLLQNASCPVKILPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIL7</accession>
    <name>A0A194XIL7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_467514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074319.1">
        <property type="nucleotide sequence ID" value="XM_018207728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIL7"/>
    <dbReference type="STRING" id="149040.A0A194XIL7"/>
    <dbReference type="GeneID" id="28817454"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_467514"/>
    <dbReference type="InParanoid" id="A0A194XIL7"/>
    <dbReference type="OrthoDB" id="5239590at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268345" description="LPXTG-domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="46720" checksum="F5174B37D94BF449" modified="2016-10-05" version="1">MLSLSIPVILTLSTFAHGLLVNPTSPQCADVCGNSLTSTSGSEMTCNDLAYYSSLYGATFKQCIACELNSTYYDPTSKVSDLNYAIYNLRYALSWCLFGLDNNTALTDTPCLTLFSCGPLQGAFEYDNLNQSASPYSYCPSLNSVSVPKCSSCLQEMGNENYLANYVTILKAACLQQPAPGGSLSIAGTPFSSTMVNITTPSATPISSYNPSSGGLSLGAKIGIAVGGLLFLLIMSGCCIVWTGKRRRRRVLAEKARASGYEWQAGRHGTTPLETSQHSNNGGHAQFFDSPQSQKPLFTTNAWGQIVDESPVSGHPDSAISRGGGGGFEKAYFSPYSSTYTSPVSAVERRGEQGWPRDQKKAVVEPEDERGERIEMGAVMSGAGEYPLDRKHAVEDFGITPVQGGGGGAGWAPILSHPGYGRGRGGLGLGEEDARRGDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJB2</accession>
    <name>A0A194XJB2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_438025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074603.1">
        <property type="nucleotide sequence ID" value="XM_018207522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJB2"/>
    <dbReference type="GeneID" id="28817248"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_438025"/>
    <dbReference type="InParanoid" id="A0A194XJB2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="245" mass="27678" checksum="B955E59C06A9BCA2" modified="2016-10-05" version="1">MREMALRHSAVMSYKGKRSSSLRGSLIRGASGSHTRRFDHSRASSAPLLPADGVLDAGRWAFPFLVGALLCLDRSHSKSHRNANIPIPPADLSTLSDMLTRIWWNGIICRMLCIYLLYFIYHQDLPCLFPVTWQMERGHNHHSEEPRIVEDFFPSYYYRAEIESYGHDAENRQTPQERIQQSGRTTNAYLNHQKVVGGTLPLPRRAGDGAASDLLSIHRSRYCTVHQIYGAEPLNQDSGSGFLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK58</accession>
    <name>A0A194XK58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SURF4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_682250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074881.1">
        <property type="nucleotide sequence ID" value="XM_018214469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK58"/>
    <dbReference type="FunCoup" id="A0A194XK58">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XK58"/>
    <dbReference type="GeneID" id="28824195"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682250"/>
    <dbReference type="InParanoid" id="A0A194XK58"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="303" mass="33992" checksum="50A9DC1517D1F4FD" modified="2016-10-05" version="1">MAQIRGTAGYNLGGQTSFGQPSRGDTMNDPSPLDAIREQTGKIEDFLDTLSDPVKPYLPAIGRFLIVVTFLEDALRIITQWSDQLLYLHDYRHIPYGLTHIFLIVNVLAMVSCSSLVIARKYSDYAVAGLIGVVVTQALGYGLIFDLNFFLRNLSVMGGLLMVLSDSWVRKSKAFAGLPELDEKDRKMYFQLAGRVLLIFLFIGFVFSGKWSVWRVIVALFGFVACVMVVVGFKAKFSAIMLVVILSVFNLLVNNFWTLHEHHPHKDFAKYDFFQILSIVGGLLLLVNSGPGKYSIDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKB6</accession>
    <name>A0A194XKB6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_779348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074958.1">
        <property type="nucleotide sequence ID" value="XM_018222283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKB6"/>
    <dbReference type="GeneID" id="28832009"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779348"/>
    <dbReference type="InParanoid" id="A0A194XKB6"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="37519" checksum="E23E7CF139C6E2D8" modified="2016-10-05" version="1">MSRQSQYHAYLQEIRVDEACKFLLKDAKFINWRHATDSQQLVILGDIGCGKTVMMAYLIDELRRRNEHQLPQPKICYHYCQNDEIGQAICTFSVLLLSLLEQFSGLKRTFFEWYQQAAASGIEPATYFKNPNEWLQKALETLDRPLLLVIDGLDECNRASRNSLLKSLRNLSQKSPRLKILLSSHPQEEIFEQLSGVAKIALGSDAGRDKVIVEKTVERQLFYLSKDVKELVTETLSRLAQGSAIWTKMTVELIEVHGIRGLGPMRVFLGETPQPEQHCLNTNHHELFSFTRPVRVGTDAATVSEGGASENGSFWDEQQEPLREAARLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKG0</accession>
    <name>A0A194XKG0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptide-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_665972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074632.1">
        <property type="nucleotide sequence ID" value="XM_018212881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKG0"/>
    <dbReference type="GeneID" id="28822607"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665972"/>
    <dbReference type="InParanoid" id="A0A194XKG0"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47239" checksum="F3F2AD858D4B1B32" modified="2016-10-05" version="1">MSISVALQSVAFYVLSCSTCAKINHRRKAKVQAKRERAEKHALETEQPGLYRHPSPFSTNPYWTEEIMMGPGPPKQKGESKNASQRALNTAGQGSSYAGSTAMSSEPPSSPTNVTENSRISGDGWNRKRYQREDEALWGHDIPGPGQRIMDAIARAGSSAGRLLEGRLSRSGPGREEEGPSHYYLAKNPPVNDLHPPVVSTAPSSREETRWMLQPPPAAKIMEGKERVNRSRASSNGSSRRGGEEIPLSRQVTERLVDARLQRGETPYSEGRPVSSKNNPRTLAPLSGPGMEHSRDRSRSPSMDSSGSSDAGMRRKRKPPPISISMSSKSSRDAVEHIPIPASIEMREQSVRPMLSTIISSSAAVPQLPIEDDGALQPTTNSAINSRASSPSRRLSPNANAMPVSIPKMEAKFPGNSDYKFHRSTSMENAEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKW3</accession>
    <name>A0A194XKW3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_779194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074772.1">
        <property type="nucleotide sequence ID" value="XM_018222276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKW3"/>
    <dbReference type="FunCoup" id="A0A194XKW3">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKW3"/>
    <dbReference type="GeneID" id="28832002"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779194"/>
    <dbReference type="InParanoid" id="A0A194XKW3"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
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        <property type="entry name" value="TPP-binding domain"/>
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        <property type="entry name" value="Sirtuin"/>
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        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
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        <property type="entry name" value="Ssirtuin_cat_dom"/>
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    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
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        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="585" mass="63333" checksum="FBE9F783AF368E90" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM32</accession>
    <name>A0A194XM32_MOLSC</name>
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        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">LY89DRAFT_430765</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
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        <property type="nucleotide sequence ID" value="XM_018207467.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="M28_Fxna_like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="M28_fam"/>
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        <property type="entry name" value="Peptidase_M28"/>
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    </dbReference>
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        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15 20" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="215"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="19">
        <location>
            <begin position="493"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="18">
        <location>
            <begin position="807"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KUJ21238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113037" checksum="ED701C8715156CAB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XME3</accession>
    <name>A0A194XME3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_433164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075775.1">
        <property type="nucleotide sequence ID" value="XM_018207495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XME3"/>
    <dbReference type="GeneID" id="28817221"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_433164"/>
    <dbReference type="InParanoid" id="A0A194XME3"/>
    <dbReference type="OrthoDB" id="5392974at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="440" mass="50376" checksum="D3E535DD2B03FD77" modified="2016-10-05" version="1">MDTLWKTHEFDAVDYSVFKAPKRQRSRVALGWAINEEDNSDNNALHWATFGNVKDWATWFDDKESLYDLEMPQKAASFLFFKRDVAPDNLPSDDANILQHIPVDEVSFRLIVDNFHIHRAFPILLENGAASFSRIPCKIGGRECKVYTLRVEEKMEKHTAITITYFPKTKDLESKMYALVLGLNDQEIIKAFGQLRAASGNLFSPFTLMKIFLELERNTRLKFVSDKVTLLETLVDIYGGLPVTMGRATPKPGTYDHRGDDSHGLLNLFLEVGYAKGGIAAWKAQLFGMKKSIKEFRAMSSPTSQEIDPSDYLSRLIEDYHVQIHKCDVLLQAIPLAFQRDTFHQSRLDTRQMKALALLTMVFLPGTFIAILMAVPEFEAMKNVRSLPPWSWYLALTLPLTAVVLVTYVLWVALGDDKWQKRFKTAWEKLNCGRRRGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMX6</accession>
    <name>A0A194XMX6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_577416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075794.1">
        <property type="nucleotide sequence ID" value="XM_018208891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMX6"/>
    <dbReference type="STRING" id="149040.A0A194XMX6"/>
    <dbReference type="GeneID" id="28818617"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577416"/>
    <dbReference type="InParanoid" id="A0A194XMX6"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268422" description="GEgh 16 protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="30649" checksum="C365D49BE41F8208" modified="2016-10-05" version="1">MPSLKQLLCVAPALLAVAYSQGVILSAQGTKGSVASLPLQVSLTQSDANIINSQEIAENAVNECGRTLLAGNIDIGENTEDQLLNKTVTSVTKGSTVSVTLNQVNADGAGPYTCDLDPTGNADGTSGQLNLTMTEKDAGDGTTTLTLTMPSDLACIGSSAGNVCTVRCFNTAAAGPFGGCFAVQQTDTTASVNQAATITTAQTLEGIQAQIEVNQKDLGAAIKANAEAATTSEQGVDAVNEILSIDSTASATAGAAEATSAANAKAAGSTTSATSAKASKAAAAAAAKAKGAKDGNGKNGRRGARVFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNX9</accession>
    <name>A0A194XNX9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_770823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075792.1">
        <property type="nucleotide sequence ID" value="XM_018221868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNX9"/>
    <dbReference type="GeneID" id="28831594"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770823"/>
    <dbReference type="InParanoid" id="A0A194XNX9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="523" mass="58720" checksum="9021B2A6BCBFE8CB" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP98</accession>
    <name>A0A194XP98_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">LY89DRAFT_388649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076259.1">
        <property type="nucleotide sequence ID" value="XM_018207165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP98"/>
    <dbReference type="FunCoup" id="A0A194XP98">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XP98"/>
    <dbReference type="GeneID" id="28816891"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_388649"/>
    <dbReference type="InParanoid" id="A0A194XP98"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ21904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="287" mass="32132" checksum="6858481AD478CD59" modified="2016-10-05" version="1">MAAPAPLRATSLRNLNLLLRTAPRFVQNQFRRQQSTTSASSSVNPEEVSHFNALASTWWDPHGSSRLLHLMNPLRHDFIRTCHASQPDAPLRSGLKYLDIGCGGGIFAESAARLGSTGSVTAIDPSSEVLAVAKGHARRDPGLKDKLTYLNTSIEGLPLLTSAEEQYDLLSLFEVIEHITHPAEFLDKCTPFVKPGGWIVMSTIARTWMSWFTTKLVAEDLARIVPRGTHDWEKYINEEELRAHFLRERGWNSPRVMGVVYVPGLGWKEVSSSERVGNYFFGIRKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPP4</accession>
    <name>A0A194XPP4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_704819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076513.1">
        <property type="nucleotide sequence ID" value="XM_018217405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPP4"/>
    <dbReference type="STRING" id="149040.A0A194XPP4"/>
    <dbReference type="GeneID" id="28827131"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_704819"/>
    <dbReference type="InParanoid" id="A0A194XPP4"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268480" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="143"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ22158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="40716" checksum="36562DD77891A6CB" modified="2016-10-05" version="1">MVLLKSLLAFTGLATLSLAKGPGGPPPTYDNSAVLDLIPDNFDKIAISGKPALVEFFAPWCGHCKNLAPVYEELAQNFAFAKDKISIAKVNADAEKSLGKRFGIQGFPTIKYFDGKSDKPEDYSGGRDLESLTEFISKKTGVKPRTKKAAPSSVEMLSDKTFKEQIGGDKDVLVAFTAPWCGHCKSLAPIWEKVAADFVNEPNVLVAKVDAEAENSKATAKDQGVSSYPTIKFFPKGATEPVAYEGGRTEGDFVTYLNEKAGTHRVIGGGLDATAGTIEALDALVSKFTGGSSISEVAAEATKAAADFKEQAQYKYAEYYVKVFDKMSKSDGYAAKELARLDNILKKGGLAPAKLDEFTSKTNILRRFVDKVTGGKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ63</accession>
    <name>A0A194XQ63_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase-like superfamily-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_574754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076755.1">
        <property type="nucleotide sequence ID" value="XM_018208755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ63"/>
    <dbReference type="STRING" id="149040.A0A194XQ63"/>
    <dbReference type="GeneID" id="28818481"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574754"/>
    <dbReference type="InParanoid" id="A0A194XQ63"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="164"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34414" checksum="2023D797CF34F5A2" modified="2016-10-05" version="1">MASPEAGSTFAAATALKCLSSHEYEANFVDDWCIGSVPHGGYATATFMQVASKHFSSTLSAQNQPHTIAVHLDFLRRTSAGPALFTVKDTKLGRQASVIHVTLSQEGREEVIGSLTQGNISAEEGVSFDTTYSLDPAPLPVNLSHLAKDQDENWARAREMPFASFRKATQKTMFHFPRERQRKRSQADEWVRLVSGEKWTDASIGYLADMWQNPYDVKNMEKTAGEKGPAKFWYPTLLLNLDIKKSLSEKPCEWLFVRVNSKRIQNGRMDLEVVIMDEEGDIIALSHHIAFALPAARNLAARRTGASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ68</accession>
    <name>A0A194XQ68_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_729665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="63" mass="7395" checksum="C9A0EB7AAC76B085" modified="2016-10-05" version="1">MSPLKYARIDKFLLSLTYFGLALQGAYSIRLYRNYQSLNTGYNKKRWALKTLEKEQGLESKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQK8</accession>
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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        <source>
            <dbReference type="EMBL" id="KUJ22451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="123" mass="14300" checksum="851816E349879E51" modified="2016-10-05" version="1">MAHHNVNFLTFLDQILPDRRSPDVRQNDIVGNAIRNTIDFWTSGLDMSNYSAHVLVIANELISLIALGDGQQRWMVILALKWLVEEAEFLVEEFEDMEDELEMVFLCGLMDELQMLWYGVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQW6</accession>
    <name>A0A194XQW6_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_548560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="191" mass="20816" checksum="E72B75BEA55AEE6A" modified="2016-10-05" version="1" fragment="single">KKIAIITGSTRAVRIGPSITKFVHSVLEAHLSTSKTTNIELSIVDIATFNLPVFDEAVVPASVPFAARNISWSTEISKYSAYILITACYNQGPPGGIKNAIDYLYNEIKGKPFLIISYGMEGGEKASESLAVSLKSMHTVVMETRPMLSLVRNESIEFGLPLDLRLAAGGTLGEESLRRWEGEKKEEVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT06</accession>
    <name>A0A194XT06_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194XT06"/>
    <dbReference type="GeneID" id="28821183"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_635734"/>
    <dbReference type="InParanoid" id="A0A194XT06"/>
    <dbReference type="OrthoDB" id="5420387at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="962" mass="106012" checksum="98E781D8F5B655C5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU54</accession>
    <name>A0A194XU54_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A194XU54"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <location>
            <begin position="1"/>
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    </feature>
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        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30792" checksum="4AF8ECFF42151759" modified="2016-10-05" version="1">MVSLRSGKVLEESNKQPTKPATLPRAPVSKKRKAEEAESTENEKENLTPAAAVEPTVSKNNATPPPPEPKEYERTPGRIGPIKKKDFSIEPNIKPFKGPPGKKVRKTFEEKEEEYAQFARENEGHCFHELHVCYAKGPNGSPTYDKSGFELDYQKVARWMNPSAYNKTAMVKGMDRAVNRAQNEQEQMAEIFYEKGEAPKGTEYFQAVGMWKDRVSKDLNVPWHKIGVAHFREWEKKGFKRVRKGEYLIVPIEQRERMTRLLSGASLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU73</accession>
    <name>A0A194XU73_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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    <dbReference type="AlphaFoldDB" id="A0A194XU73"/>
    <dbReference type="GeneID" id="28815314"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_177300"/>
    <dbReference type="InParanoid" id="A0A194XU73"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="184" mass="20743" checksum="C34F25BCCFBB1DBF" modified="2016-10-05" version="1">MQMQTQLTQIIVLTTPPFLINRVISHHTTRQTQSCLSINQTRSHSLLHPDFHPHPQSLTRHKAGVTRKRPDPISVCHCRGQQRREPDPSPSAAALAFTLSRQILEASRIKSRAGLGSSILWHLSPFEYANNSHRKSTMREMFAVERNRQTPAFAETYGYGFPVFRLGLSVSTRGNGNAVLCCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUF5</accession>
    <name>A0A194XUF5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative ABC bile acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_31</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078024.1">
        <property type="nucleotide sequence ID" value="XM_018206624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28816350"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_31"/>
    <dbReference type="InParanoid" id="A0A194XUF5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000092">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="409"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="619"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1285"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KUJ23669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1567" mass="172867" checksum="E6C9D3D5569DFDA9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV64</accession>
    <name>A0A194XV64_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_726969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078274.1">
        <property type="nucleotide sequence ID" value="XM_018219109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV64"/>
    <dbReference type="STRING" id="149040.A0A194XV64"/>
    <dbReference type="GeneID" id="28828835"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726969"/>
    <dbReference type="InParanoid" id="A0A194XV64"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="602" mass="67487" checksum="1909FF18FC12C5D3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVM5</accession>
    <name>A0A194XVM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative aromatic peroxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_703412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078638.1">
        <property type="nucleotide sequence ID" value="XM_018217321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVM5"/>
    <dbReference type="GeneID" id="28827047"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703412"/>
    <dbReference type="InParanoid" id="A0A194XVM5"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268669" evidence="8">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="46776" checksum="A27F2A9D995E4E17" modified="2016-10-05" version="1">MKTSLVSLAVLAIAVSEVAAFPALAAEHAERLANSQRGKRSTLARSIHKKRVTFDPASQYTSTTGAHAFVPPNFAAGDVRGPCPGLNAAANHGYIPHNGVGTMGDFVNGTNEAYGMALDLGGFLAVYGSVFDGNLLGYSIGGPTSLNQLPLNNLLGLTGAPQGLSGSHNKYEADTSPTRGDLYLYGNDYEVQVPQFQQYYDALIEGVDADTQYANLIDFRIARFNDSITRNSHFFYSPFAGVLVSPAGFSFPVRMMANHSAEFPEGSLSKAQLMSFFSITGKSGKFVYTVGHERIPDNWYKRAIGDEYTIPGFLADVLDFGEKYPPLLDVGGNTGKTDSFTPVDIGSLTKGVFSAADLLEGNNLECYALQISQAALPDILGGAETNIGDLTQILKPLSDNIAENLLGLGCPTLNGIDDSQYDVYPGYNNCPNGCSGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XW84</accession>
    <name>A0A194XW84_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_8345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078337.1">
        <property type="nucleotide sequence ID" value="XM_018223442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XW84"/>
    <dbReference type="GeneID" id="28833168"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_8345"/>
    <dbReference type="InParanoid" id="A0A194XW84"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="193" mass="21951" checksum="F34CF3A95F931340" modified="2016-10-05" version="1">MAPSHFTTNETPSCRRSSTKMLLSYLNNAGFSSPSLQTTPFRSPRAANGLQIPDPELVPSWCLMLLLPYLLCLNNRVPTEVRASLTNGEGQDATAVDNTTRKKALNGQKNAGIDRRELRSNLQEKRQQISYTILRTWLGRSFESIPYLEILLIRKLELRKSSNHGSNLQNSTRSFPIMDEYGMVLTRKYNDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWC7</accession>
    <name>A0A194XWC7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_604354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078382.1">
        <property type="nucleotide sequence ID" value="XM_018210354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWC7"/>
    <dbReference type="STRING" id="149040.A0A194XWC7"/>
    <dbReference type="GeneID" id="28820080"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604354"/>
    <dbReference type="InParanoid" id="A0A194XWC7"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="301" mass="33305" checksum="79EA4FCD71550C13" modified="2016-10-05" version="1">MAYRQNFNPDSLPAFAEPERKHGNSSSSSSTPQYNQPPPQQAYSSKPPPPLPADQQAGGRRLSPQMQPHGYGTPPPNRGYASPPPNQQYGGGRPGHSSPPLPPQQQYGTGRPGPGGRAPPISRPPPSPAPPAGADPALWPLFKAVDKAGTGNLTEKELRAALVNGDWTSFDPHTVKMMIRMFDTDRSGTIGFEEFCGLWGFLAAWRSLFDRFDTDRSGNISLDEYTNALVAFGYRLSPQFVDTLFRTYDKRGEGAISFDLFVQSCISLKRMTDVFKKYDDDRDGYITLSFEDFLTEIIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWH2</accession>
    <name>A0A194XWH2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ferrooxidoreductase Fet3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_23441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078836.1">
        <property type="nucleotide sequence ID" value="XM_018206051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWH2"/>
    <dbReference type="GeneID" id="28815777"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_23441"/>
    <dbReference type="InParanoid" id="A0A194XWH2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268700" evidence="6">
        <location>
            <begin position="17"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="147"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="356"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="537" mass="59600" checksum="3CA5FF61A60BED04" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWM9</accession>
    <name>A0A194XWM9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_634045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078487.1">
        <property type="nucleotide sequence ID" value="XM_018211374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWM9"/>
    <dbReference type="GeneID" id="28821100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634045"/>
    <dbReference type="InParanoid" id="A0A194XWM9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="488" mass="54488" checksum="3F51DD4B5CB6CC6C" modified="2016-10-05" version="1">MCILIYLCSTMNGYDGSLMGSINAIGSFQQYYGLSENGAASTGIVFAIFQVGQMAGALFIWLADWRGRRLSIFIGTLGVCVGTIVTSTAKDLSTFIGGRFLLSFFSTLATTAAPLYLIEIAPPMYRGTVAGLYNTLYYMGSILATFTVYGANLHLSGNIIWRLPLWLQMVCPGFVALFVWFLPESPRWLIGQERFEEARAIIVKYHANGDDVHPIVELEMSEMTDSMRDGGLMTWKSTFDIRNLFNSRSRRYRLALCIAFSWFGQFSGNNIASYYLPLLVENVGITNTNTQLLLNAIYAVAGWVFAGSGARFHDVWGRRKMLMGSTFGMAVCLAIVAGTAAGYVHDPSNKAMSIASITFIYIFGCVFAFAFTSMQPIYPGEVLDNIQRAKGMGVFQLTGGAAGFLNTFVAPIALKNIGYWFYVFFVFWDLFEFAVIYFFFVETKERTLEELDEVFEAPNPRKASVAKTRIRRARIHDEDGNEKDVIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWT8</accession>
    <name>A0A194XWT8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ESCRT-1 complex, Vps28 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_679410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078562.1">
        <property type="nucleotide sequence ID" value="XM_018213865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWT8"/>
    <dbReference type="FunCoup" id="A0A194XWT8">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWT8"/>
    <dbReference type="GeneID" id="28823591"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679410"/>
    <dbReference type="InParanoid" id="A0A194XWT8"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ24207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26014" checksum="01832932A36508BA" modified="2016-10-05" version="1" fragment="single">MYQPRQAYAPTPHSYVPSTISATINLDEEVKLAETRAERDLQDSLAEVFSIIITLDELEKAYLKDAISETDYTEICGRLLNQYKAILTDEGVSRAFVDLETFKNEWDMEVPRATERIRIGLPSTVTAPAINAPANNNSGSNGTLILEATQDFITFLDALKLGLLAKDQLHPLLSDVIQSVNKVTDRDFDGRGKIVQWLIALNQMKATEEVSDDQARELELDMNSAYQGFKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1A7</accession>
    <name>A0A132B1A7_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Putative GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_703086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947457">
        <property type="protein sequence ID" value="KUJ06156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018217288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1A7"/>
    <dbReference type="GeneID" id="28827014"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_703086"/>
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    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="212" mass="23755" checksum="35386EB95DD8E45F" modified="2016-05-11" version="1">MPLKLYYATFTDAPRIAEIYMAAFGSNALLCAQFPTPAVRAALQVAIDVLVIRDLREKDEGGVSMQEDEVNGKVISFSKWGHPVHEGEDNTEPMWVWPEGSNIKLLDEWAHKTDVAYKVALGQTPCYRLSFLGTDPLYERRGAASLMLQWGINQCKKDNALAYLESTVETRPLYEKNGFVRVEALSTSINGLLGDGSSMFYKEICFLFQAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1J8</accession>
    <name>A0A132B1J8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947449">
        <property type="protein sequence ID" value="KUJ06258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060613.1">
        <property type="nucleotide sequence ID" value="XM_018216567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1J8"/>
    <dbReference type="GeneID" id="28826293"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692593"/>
    <dbReference type="InParanoid" id="A0A132B1J8"/>
    <dbReference type="OrthoDB" id="4749037at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="376" mass="42508" checksum="A78631D7FB86DB21" modified="2016-05-11" version="1">MGHNPKFVGPVRQPPIHKSGPQELLDPEPREVAPTMKTQGCLDGEKCASTIQWDKYNFNAGTCESNGPIYPADQARVDFVKMIDEGAQLEYCSVCEKTHICPGPPITLPDRDTCGAFLPRWFPKGRFPKPWATYLELMSDITTMEAFKNDPKAVWDKYFHKADDKWESIGREDGGWWKCRVGSDASWAELECTLCHRARYNAAWEQEQRKQRRDVLERLKKLKAWKAKHEKECADRDKAVALAMIRDGPPPMALLTPLPAEPVPPLKIPYDSDDGEGDWTMGPYAGQIVWKAKPYNSKPVIVEKSGGSESQDFKADELTRSISALDLHQIAVEHHEETPVQTFNESGGEVKRGRSLTRKSFSSTSSTRSPNKLFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2N7</accession>
    <name>A0A132B2N7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative PI phosphatase group protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_790307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061011.1">
        <property type="nucleotide sequence ID" value="XM_018223353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2N7"/>
    <dbReference type="STRING" id="149040.A0A132B2N7"/>
    <dbReference type="GeneID" id="28833079"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790307"/>
    <dbReference type="InParanoid" id="A0A132B2N7"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="791"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1161" mass="129450" checksum="8BC9CB2D55E971AE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3T8</accession>
    <name>A0A132B3T8_MOLSC</name>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
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        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
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    </dbReference>
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            <end position="222"/>
        </location>
    </feature>
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            <end position="22"/>
        </location>
    </feature>
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            <end position="183"/>
        </location>
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        <location>
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            <end position="272"/>
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    </feature>
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            <end position="338"/>
        </location>
    </feature>
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            <end position="380"/>
        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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            <dbReference type="Pfam" id="PF14636"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ07052.1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="8 9">CBS 120377</strain>
        </source>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3 9">L-lactate dehydrogenase</fullName>
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    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 9"/>
    <dbReference type="EMBL" id="KQ947442">
        <property type="protein sequence ID" value="KUJ07064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061419.1">
        <property type="nucleotide sequence ID" value="XM_018223337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B598"/>
    <dbReference type="STRING" id="149040.A0A132B598"/>
    <dbReference type="GeneID" id="28833063"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790147"/>
    <dbReference type="InParanoid" id="A0A132B598"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="146"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ07064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33214" checksum="16919EFFC72903BE" modified="2016-05-11" version="1">MSASGGSIAIIGAGSVGSAVAYSLLLRQVVADIVLVDINHELCQAQVNDLSDATFLSNVRIRQGSVQDAQNADIIIITAGAKQKPGDTRLNLIDRNYKVLKSILQSLQPIRNDSILLIVANPVDVLTLFAQRLSGLAKNQVLGSGTLLDSIRLTRILASKLEVADTSIHAFVIGEHGDSQCVAWSTATVHGTPLLKVLPLTDNEREEIATTTRKKAEAIIKVKGFTSYGVAAVTSRICEAIIFDHRQVLPLSHWQQDLDCCLSLPAVLGRDGIISSFPLHLDEEEQSFLSESAKGLRKVIEEYKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5I6</accession>
    <name>A0A132B5I6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_369247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061509.1">
        <property type="nucleotide sequence ID" value="XM_018207048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5I6"/>
    <dbReference type="GeneID" id="28816774"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_369247"/>
    <dbReference type="InParanoid" id="A0A132B5I6"/>
    <dbReference type="OrthoDB" id="3061143at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="511" mass="57579" checksum="67C84C9D7356DA45" modified="2016-05-11" version="1">MRSTKRFRYFRASLPSSRWDNSALMMPAVEFNYKAPVARAGGGIRIAPNFPTDTGPINMALATARNSEVPRLLKKSGELTKEDDSILYYHLQSNEPVYVGKDESDEIFNGVWLNESAIQKLPTAWNNMLKLREMLLKRGEGEYRDRSAFEMILAGRDTRNDSFKSPRCYKIGFTVFPLEPETDMLECGMVEPNKVMIEHQELIVDASRLAAAITTEIVEANAPPEVLKMLARRAAIDVPMMIGSEKNIYSTTCQLNFSDGDEASLEIALGDDGTLHVDVHDDIRQWTTLISLSNNVTGYWPGRTLITSHRIYAVMAPFTVLLCKAANPHLSIRPELMVGSDRAPYLPSVSSVPTLDPEEHISARVTAVNYSNEAIMNRSPLLAREHSSILLQKFETNGELPRSPHALPSALMAFGTRKNQFEWLACATAWEKALLARMNDSYVLPSTIEISRLFRWREAGVTHMPDVQRIQKVLDGNEDTPENRQQDEEDEEFAERCREQLSQGCFEDAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5K2</accession>
    <name>A0A132B5K2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_601038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062037.1">
        <property type="nucleotide sequence ID" value="XM_018210180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5K2"/>
    <dbReference type="STRING" id="149040.A0A132B5K2"/>
    <dbReference type="GeneID" id="28819906"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601038"/>
    <dbReference type="InParanoid" id="A0A132B5K2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="491" mass="52941" checksum="CF7B8BF19A2E6277" modified="2016-05-11" version="1">MAPSATNENGHSNGTAKLDFTTFSNTINGKLVPASDGATRHGINPATKKANPPVPVATKKDLDAAVEAGRAAFKKWAKTSVQERREALVKFADALGSLQEEFAQLLTMEQGKPLMFARQEVQSGPAWIKGIGNLDIPEEVVEDNEDRKVITRYTPLGVVGAIVPWNFPVQLACGKITPAVLTGNVIIVKPSPFTPYCDLKIGELAQQFFPPGVVQVLSGDDNLGPWITSHPGIDKISFTGSTVTGKKVMESASKTLKRVTLELGGNDPAIICKSVNIATVAPKIATLAFLNSGQICLCVKRIYIHKDIYNEFRDAMVEHTKTFKVGNGTEDGVFLGPVQNSMQYEKVKGFFDDVEKNGMKMAVGGKVSETGGYFINPTIIDNPKEDSKIVQEEPFGPIVPIMTWSDEDDVVARANDTQMGLGASVWSSDLDEAARIAKQLEAGSVWVNAHIEVSPLVPFGGHKQSGIGSEWGSSGLKHFCNSQSLFLKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6Z6</accession>
    <name>A0A132B6Z6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_337277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062540.1">
        <property type="nucleotide sequence ID" value="XM_018206829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6Z6"/>
    <dbReference type="GeneID" id="28816555"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_337277"/>
    <dbReference type="InParanoid" id="A0A132B6Z6"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287936" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="27660" checksum="ACF8FB743DEF16AC" modified="2016-05-11" version="1">MFSRRQLRLLTVFVLFFAIAQASWFDLSIFGRDNGKKGVDAGDSSSTNSSSNANQAVSTGVSSTPSSTPVSSTPSSIPTSATSQTSASPSSTPSSTPSSTPPSSTPTSSSAAPSSTPTSTPTQTSDTNSQTSKNADTTSDSTQQTSTSATVVRSTIVMTVSGSLTTSVSSSTQSSAATGTGASGQLSGDGTSSSSGMSPKTKNTVIGVVVGIGGAAILAGLFVVAWRIWGRKKAEDDDDGLMGFRTGSAGGSNPFQSTLENYHNPARNVNASSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7Q6</accession>
    <name>A0A132B7Q6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_765453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062374.1">
        <property type="nucleotide sequence ID" value="XM_018221670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7Q6"/>
    <dbReference type="GeneID" id="28831396"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_765453"/>
    <dbReference type="InParanoid" id="A0A132B7Q6"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="242" mass="27976" checksum="7D0563975A18EB24" modified="2016-05-11" version="1">MIREPAAMASTIPQVETDEPIYFWREHSSPHGYMSQWYHSPFTCPSTTTTYKTAEQYMMHRKALLFSDPTIAAQILTTTSPKAQKALGRKVKNFEQKVWEEERERIVEEGTWLKFRYGVDRGELEGEGVSLRERLVGTGERELVEASPMDRIWGIGFTEKRAGEMRDKWGMNLLGKALMKVRERLRAEEVGDGEEDVKKDGEKEVEKAPEFRAGKDNEVKENDHHGQDEEERPKKRTRSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7V4</accession>
    <name>A0A132B7V4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_600003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947436">
        <property type="protein sequence ID" value="KUJ08333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062688.1">
        <property type="nucleotide sequence ID" value="XM_018210130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7V4"/>
    <dbReference type="GeneID" id="28819856"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600003"/>
    <dbReference type="InParanoid" id="A0A132B7V4"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ08333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="377" mass="40391" checksum="FB6AB976C3041FA4" modified="2016-05-11" version="1" fragment="single">FDAQDQLVSVTGEYVWQSPAVSDIRGPCPGLNAAANHGYLPRNGIATIEQTAAGLEALYNMNPVLGAALAAYAVATDGNVVEGVWSIGGPLPSDPLLGSLLGDGQGISYSHNAYEGDASIGRNDAYLNNGDAHSLNITKFEQVYAVGGAEDRYTLDKFRARFETVQDESIANNPYYFTGAFSTVVVVPAAYNFVINFMSNHTAQEPSGCLDGYNFKSFFGVTGQPGSFVWQRGQERVPDQWYRRPTSNQYTAQDVFLDVGIGYAAYPNTLKFGGNTGTPNSFVGLNVANLSGGVYDAQDLFQGDNLACFSFSVLQEGIPDFLSNTLNSMSAVTSLINQYFGPIVGGLNCPQIQGQSTGLFNQFPGYKYSPIGPATNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8L5</accession>
    <name>A0A132B8L5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
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    </reference>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="453" mass="50524" checksum="81F0A42ED12FE7CB" modified="2016-05-11" version="1">MSSCSYASSTDSAELNFQGVYIAGKPENVQYDVCCKQGVITSMTESQPDQPYGGLLVPSLCHPHIHLDKSYLLSHPKYADLEIEKGDFAEAMKLTSEAKARFDLEDLMERGRALIQESINFGVTHMRAFVEVDLGVKLKCLEAGLALKEEFSDRCHIQICVFAQDPIFSYRDSGRAMQRMLENAASKPGVEAFGSTPYVESNGDLHKQIANIEYAIKIAKRYKLHLDFHIDYNLDPNKQSMVIEALRLLHKMNWPSNFNYPTYRTIIFGHCTRLTLFTTEEWEQLQEQVRGLPISFVGLPSSDLFMMGRPTEKDEGSQRVRGTLQVLQVIRKYGMNAVIGVNNVGNAFTPQGSADPLALASLGVGLYQAGTKQDTDLLLQCVSNRAKLAMGIVQSTPYEIDIDVSDPAEFVVFGSKLSTGSKSFRARRTIQDVVYDPAPDRITVYNGEVVSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="A0A132B8N1"/>
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    </dbReference>
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            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="26"/>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="394" mass="41796" checksum="0EAC2C776D6820C6" modified="2016-05-11" version="1">MADSSETHSLSKEGASEYAPQADMTAGQSSTTGASKNLHSAPISPPDYGTQDGYEMQSLPRLVNQSPAALPVPPPQVQAYEEPFNFNFYRPKKDIRTYLLSLVFLLALALVAVATVFGVKFANLKQQMKDQPKAQNTTLTVYSTDSTSFLSTYTSTASTTLSTTASTTLSKTLLTTLVESFTLPPVTTVSTQTDSTTLLSTVSTTESTTYSTTDSITLSMTLTQSVTLPPVTAVSTLVQQTTIVQISTLQTTLPTATTQLSTVTATSTLSTIQPSAVSACWVLLDDICNNSTQVPPDLTNDGFGNCSTIYRFFYCGLINHLEAIGDLILPADSSPICGGMKEFCNSNEANSTEALVEPPAPPEIRIILASTGIEQVSGGTNTTTLAKLAEHTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B933</accession>
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        <submittedName>
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    </protein>
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        <name evidence="5" type="ORF">LY89DRAFT_764342</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000070700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="232"/>
        </location>
    </feature>
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            <end position="599"/>
        </location>
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        </location>
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        <location>
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            <dbReference type="Pfam" id="PF03033"/>
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        <source>
            <dbReference type="Pfam" id="PF06722"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ08881.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1382" mass="150315" checksum="78FAFDD594135055" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9V9</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
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    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
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        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
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    </dbReference>
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        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288048" evidence="1">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="290" mass="31685" checksum="2BF79022E31F2179" modified="2016-05-11" version="1">MMYMSSVQLMLMGARLVLYDGSPFTPDPKNFIRLVGEQKITHLGISPRYMQTLQMNGINPKDVTDLSHLKIVTSTGMVLSDALFEWFYDFGFAPSTQLCNISGGTDIASAFGTANPILPVYVGGCQCISLGMAAEVFDSTIEGGQGVKGVPVEGGVPGELVCTKAFPTMPVKLWGANSAERCWTHGDFIMIHPQTRQVIFLGRADGVLNPSGVRFGSADIYSVVDANFSDIIADSICVGQRRPQDNDESVMLFLLMKPGKAFTPDLVRRVRAAIRKEHSPRHVPKYVVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9X8</accession>
    <name>A0A132B9X8_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_788118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063567.1">
        <property type="nucleotide sequence ID" value="XM_018223136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9X8"/>
    <dbReference type="STRING" id="149040.A0A132B9X8"/>
    <dbReference type="GeneID" id="28832862"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788118"/>
    <dbReference type="InParanoid" id="A0A132B9X8"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288051" evidence="1">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="23802" checksum="61B815ED38FDF6B2" modified="2016-05-11" version="1">MQFSKLAAITSLLAGVIATPIAGEATKLAKRSEGVHLVNCGSEYSVVVYCPNDSDCNHSPPSGDGCFISGIDTWEGFEQSCTFSTGTTFTWNIEAYAQSEPDYTEVGTGTNTYHNFDIYKDDQHVMYYDGNGYACKSIYYCLDNQSTLGLSGLGSMYPQELVRKCRETDHKLRPTIDEVIVSINEALATFNEGSFSTMEMESHIHDQYPGIELCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BA74</accession>
    <name>A0A132BA74_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_282298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ09281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BA74"/>
    <dbReference type="STRING" id="149040.A0A132BA74"/>
    <dbReference type="GeneID" id="28816193"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_282298"/>
    <dbReference type="InParanoid" id="A0A132BA74"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="274"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="495"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="772"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="934"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="809"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ09281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1255" mass="137676" checksum="F5ED1E5C106797AC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAI8</accession>
    <name>A0A132BAI8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_598116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063785.1">
        <property type="nucleotide sequence ID" value="XM_018210020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAI8"/>
    <dbReference type="STRING" id="149040.A0A132BAI8"/>
    <dbReference type="GeneID" id="28819746"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_598116"/>
    <dbReference type="InParanoid" id="A0A132BAI8"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="262" mass="29717" checksum="71565FD5197E236B" modified="2016-05-11" version="1" fragment="single">MGGCGKSQLALEYCRQGQNEKWFSAILWLDASSPMSISQSFANVANKLLKSNFDIADDKGNIRFVLDTIEAWKSRWLLVFDNFDNPSSFGNTSINEYFPRGGYGSILFTSRHAVAKSLGFCIEVTTMSNKEALQLLLERSRAEKTSENTQEAADIVKRLGYHALAIDQAGAYIQARGLDLNLYMTHYSERKEKVLNEVPELWDYRRKLTTDAEFETKLTVFTTWELSIELIKGSPAVRKDKDHLLTLAGFLDGKEISDELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBX7</accession>
    <name>A0A132BBX7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_290074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063864.1">
        <property type="nucleotide sequence ID" value="XM_018206512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBX7"/>
    <dbReference type="GeneID" id="28816238"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_290074"/>
    <dbReference type="InParanoid" id="A0A132BBX7"/>
    <dbReference type="OrthoDB" id="3524686at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="281" mass="31205" checksum="263C069FC890A05F" modified="2016-05-11" version="1">MPVSQISNDANGNIDPLLLFMPGTAVSVGDNIALSSPRQSFTITSRESNSIRESSEVCNIVSEYDVIEVEDPTNLDEESQALEAGESITHVATTPKAFTTPADDNDWLDLSTIRDTLPREKPLVESTDVLTYEDIAIETGGRKCLKEDFVFVGDSLDPDIRNIHDRKELPDSYISGAHSSPGNSPTEGISTSHQDPEYQQLSEQAVQETRPSPVDPEDNQFEVERVIDDQVVPVGRGRRKKMITQYWVKWKGYPEDDNSWVNEADMHGDLIKAYMAGKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDG2</accession>
    <name>A0A132BDG2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064052.1">
        <property type="nucleotide sequence ID" value="XM_018220626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDG2"/>
    <dbReference type="GeneID" id="28830352"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740773"/>
    <dbReference type="InParanoid" id="A0A132BDG2"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="38373" checksum="B19986EE638E1122" modified="2016-05-11" version="1">MGSDHSKKPQSILPSSFQSLPYEIREQIWLYTLLPRLIYIHPHQRLEPHPYDHESNELVDGLRMTASVRFNHSLHTTSSTPAEAFASYASFVVPDPHYVGRMDGEFLNYEHKLAVQPLAWRGGQAPPALHVCGESRAIALRKGYVLAFKGVDLRLEEEDKEYWKNNHLSDKGIWVNFSTDLIMLDALYRSRMYPKWAPLQPLVVLNKWAPEDVKRIRYLALGGNPGMVLSALRGNCVPVPHGPRWRTEWQWWVSLGYDNLEEIWIDDEFEVTQKEKYYEVSWRDWECQKGAAEQCIRAISMGRSKLPHWTSPLPEVKVVRGKDWRVYFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDR8</accession>
    <name>A0A132BDR8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">LY89DRAFT_689963</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064494.1">
        <property type="nucleotide sequence ID" value="XM_018216002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDR8"/>
    <dbReference type="SMR" id="A0A132BDR8"/>
    <dbReference type="STRING" id="149040.A0A132BDR8"/>
    <dbReference type="GeneID" id="28825728"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689963"/>
    <dbReference type="InParanoid" id="A0A132BDR8"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288164" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="24">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KUJ10139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="477" mass="49000" checksum="381A7A34DF099521" modified="2016-05-11" version="1">MRSFILGALLPALTWAAPAAKRDDAEPTLMTFTFAGELVTATYYGTATSTGAEACPTETFTYDGAVITVPYTGPGTPQSCLTAVSSAAAPCPTETFTYEGVVITVPYTGPGTPQSCLTSSESTPTSASQVESSEPSTTVSAPTETSAPASVATSSPTTIATGPGDGGPSVATSDLVSPTTSTSVAASTSSSSSTVAKGFNYGSSGMTQSTYVTQFNLARDLIGTSGFTSARLYTSIQDGTTAGIISAIPAAIATKTYLLLGLFYPNVDNEIAALTAAIDEYGTDLADLVLGISVGSEDLYRDSVLGINANEGTGATPDELVSFIQATRNAIAGTALSSTLVGHVDTWNSWTNASNAAVITVSDFIGMDAYPYYQTTDDNVISNGQSLFETAYDATVAVAGGKPVWITETGWPVFGSTEANAVASTTNAEIYWQQVGCGFAFDKIPTFWYDLVDEGAVPSFGVTDGTTTPLYDLTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDT6</accession>
    <name>A0A132BDT6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064349.1">
        <property type="nucleotide sequence ID" value="XM_018215988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDT6"/>
    <dbReference type="GeneID" id="28825714"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689873"/>
    <dbReference type="InParanoid" id="A0A132BDT6"/>
    <dbReference type="OrthoDB" id="10398146at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24471" checksum="9F810A5B714356E6" modified="2016-05-11" version="1">MRQFPITFVNGYCTSCMGSDHSSHSGSINTIETVDTDVSSDVKAIGDKLDTLIESCGTIAGVVNSEARRRSSISSPVKVVQFAREVGLRPSDIKIPISKPITTSKESKDGNPLTRDITAPMAVLQEELNKYFQFWRTCLNETIERQLAGNPDMKAVKECLHASYQWLDDNTSKAFEDAERLVTSKCRERVYLVCLFVITAFFFGFLFGVWFNNAWMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BE30</accession>
    <name>A0A132BE30_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_675329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064858.1">
        <property type="nucleotide sequence ID" value="XM_018213501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BE30"/>
    <dbReference type="FunCoup" id="A0A132BE30">
        <property type="interactions" value="1127"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BE30"/>
    <dbReference type="GeneID" id="28823227"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675329"/>
    <dbReference type="InParanoid" id="A0A132BE30"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="554" mass="61737" checksum="C3B855D5F0A9DE1E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEH9</accession>
    <name>A0A132BEH9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BSP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064609.1">
        <property type="nucleotide sequence ID" value="XM_018215926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEH9"/>
    <dbReference type="STRING" id="149040.A0A132BEH9"/>
    <dbReference type="GeneID" id="28825652"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689546"/>
    <dbReference type="InParanoid" id="A0A132BEH9"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="34238" checksum="EF4A8B7CB6E615E0" modified="2016-05-11" version="1">MTETSPLPPLVFMPAQSSRTEAPTPSATPLPPASQKPPVTRNSPAKETASSKTPQFILPKLRLEIRDLNHEGAEVFLTAVIASKALATSVRSVLSLLYHTPDSPTTTVPSTRSVTLILRPMEGVAYTTGSDLDSDHKEIHFSLDYINGIAASRKKDEIMGVLTHEMVHCYQYNAFGTCPGGLIEGIADWVRLNADLSPPHWKKEATGKWDAGYQHTGYFLEYLEQRFSAGTVRRMNEKLRIVRYEEKRFWTELIGRPVEQLWGDYSEAVEKERKQNKDEEGVLVEKEDASTPKLPKDPSTPTTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEY2</accession>
    <name>A0A132BEY2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_656206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064779.1">
        <property type="nucleotide sequence ID" value="XM_018212370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEY2"/>
    <dbReference type="GeneID" id="28822096"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_656206"/>
    <dbReference type="InParanoid" id="A0A132BEY2"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="55"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="430" mass="46033" checksum="1A42091664139871" modified="2016-05-11" version="1">MMYSLIRIISTFSILSIAIAYPSNVFPLRRRHEVTRRGFSQGLVSLLSTSLGEIVDAEVKLGGQSFFVEIDLGSSDLWVVANGYQCIDRSTNAVLPQSSCSYGNSTYTPSSTFSLIANETFGVFYGAGIAQGMVGNETVTFGNITVPQQTVGIVASTTNQGDGVNSGILGLAYPDLTSAHPGTDIDNTTFLYDRLPYNPLVFNMAAQGLIEPFFSLAIERTAFDQETGPGGYLSLGEIAPVPHSSKWVSTPVVILDQIPINVTANKRQLSYWALEVQSVYYGSQTSPSKRNSAPTDASHLSGNKTSFNAVLDNGNFNTFLPSAVAEAINADFSPPATSPGPTGSGDYQWPVACNATPPAFGVKIGGEIFWHDARDMIWNNGDGTCSSAIARAEDVALEGVVASFLGIQFFKNVVSIFDFGQNEIRLAARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRZ5</accession>
    <name>A0A194WRZ5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_689384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065105.1">
        <property type="nucleotide sequence ID" value="XM_018215898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRZ5"/>
    <dbReference type="GeneID" id="28825624"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689384"/>
    <dbReference type="InParanoid" id="A0A194WRZ5"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="242" mass="27166" checksum="4BB9015807318E0C" modified="2016-10-05" version="1">MASPEGPVTQSVTTLLKPGLRLGDDNESPENQEFIRLNKLLKAQPGCLSQYWGHQVENPNIFMWLIDWESKPIYNTFRESPAHDDIAGGVGKLMQFDLDSAPVFVTFTKWDKDAKAALKAPVTEFAYFKLPDGAGEKEENECRELLSTIPDYVTTVGKALGSATGWVFLVEPESAKAPWLHGVYGWQDIEAHMRWREMPEIQAPVKVFMEAGKKGLALVPAVEVPGINKETGWFHVRFHHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSB8</accession>
    <name>A0A194WSB8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_739848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065218.1">
        <property type="nucleotide sequence ID" value="XM_018220513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSB8"/>
    <dbReference type="GeneID" id="28830239"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739848"/>
    <dbReference type="InParanoid" id="A0A194WSB8"/>
    <dbReference type="OrthoDB" id="3548363at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267402" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="10233" checksum="F5AED91F1F3B2E24" modified="2016-10-05" version="1">MLFNAPKLALLALISSVSAQAGLNCSVKGYDTGKHPAYYVNSTITTPAACKAYCAASVASKCSSFAVGGGCLLYNVTVNGNVNPMNTSTFTFYDEACTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSW9</accession>
    <name>A0A194WSW9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion-related small GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_688997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065401.1">
        <property type="nucleotide sequence ID" value="XM_018215826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSW9"/>
    <dbReference type="STRING" id="149040.A0A194WSW9"/>
    <dbReference type="GeneID" id="28825552"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688997"/>
    <dbReference type="InParanoid" id="A0A194WSW9"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="250" mass="27432" checksum="93B8BA878F48C9AB" modified="2016-10-05" version="1">MASWDYIAKLVCIGDSGTGKSSLTIRLCEGRFSAQHDVTIGVEFGSRIMPVGPPHTPIQKPEISRTSSVADISEGLPEPRRKEPEIEQKHMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDISRRPTFLHVMDWLNDLRQIAEPDIVVVLVGNKSDLADENKREVTQVEAEEWAKKNGVLEYVETSAKSGEGVEMAFGRVAERIYQNVEAGKYDLNDRRSGVKGPPVGGNKGVKLGTQGKKSGYGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT27</accession>
    <name>A0A194WT27_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_556462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065466.1">
        <property type="nucleotide sequence ID" value="XM_018208375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT27"/>
    <dbReference type="GeneID" id="28818101"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_556462"/>
    <dbReference type="InParanoid" id="A0A194WT27"/>
    <dbReference type="OrthoDB" id="5428966at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="137" mass="14231" checksum="E6F2A47910C5CE0B" modified="2016-10-05" version="1" fragment="single">DRTAGIDVKEGKYGTALQAAAITGSTLIVRKLIAKGADVNTSGCGWFGNAFQAAAATGSTEVVRLLLEKKANPNALGGWYGNALRAASTKGYVDIVRILLAADFEIYLRGLFYGNALQAAAAEGHTQVVEMLIAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTT5</accession>
    <name>A0A194WTT5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_243306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065720.1">
        <property type="nucleotide sequence ID" value="XM_018206137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTT5"/>
    <dbReference type="GeneID" id="28815863"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_243306"/>
    <dbReference type="InParanoid" id="A0A194WTT5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="157" mass="18012" checksum="F283E5146E2995E3" modified="2016-10-05" version="1">MFGTCHASWYLIWRNTPSLAAHCCCRFESHIKITLTLLVFVRLRSSLKSQALPFSPNHLNFTMSKPNQHKGSFIGIKSFKFAIQPPTVWVMRKPRKISPTQRRLKVSQKEINPTSVDFFFTYAAAFKRSNGAECVYNRHISNGHKQNHLCSLNSGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU12</accession>
    <name>A0A194WU12_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_674042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065803.1">
        <property type="nucleotide sequence ID" value="XM_018213408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU12"/>
    <dbReference type="STRING" id="149040.A0A194WU12"/>
    <dbReference type="GeneID" id="28823134"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674042"/>
    <dbReference type="InParanoid" id="A0A194WU12"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF226">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="564" mass="64522" checksum="3193EC4DD453D350" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUN8</accession>
    <name>A0A194WUN8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_594291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066033.1">
        <property type="nucleotide sequence ID" value="XM_018209792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUN8"/>
    <dbReference type="GeneID" id="28819518"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_594291"/>
    <dbReference type="InParanoid" id="A0A194WUN8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="346" mass="38786" checksum="10545FBDC262A6CD" modified="2016-10-05" version="1">MATTTSQVETVHITTNGTALAKTALKVVLGAMVLGKEGAEIARVHDLKDCAALLDVLQKHGHNEVDTARVYGSSEELLGQLKLQERGIVIDTKVKSIPRGPMYSHKKDGLKRALLDSLKALQTDKIDLWYLHAPDRSTLYEETLEAVDDLYKEGYFKRFGLSNYAAWEVAQICELCERNGWKKPDVYQGGYHALQRTVEPELFPCLRNYGIAFYQYSPIAGGMLTDKYHRNTIEHEEGSRFDPKKMQGKAFRGRYWNDAHFDALDVIRPVAKKLGMTTAEAAVRWASHHSLMKREYGDAVIIGASSTVQLEENLANLEKGPLPEEMAKAFDEGWEIVKGVCGSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUY4</accession>
    <name>A0A194WUY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_234239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066136.1">
        <property type="nucleotide sequence ID" value="XM_018206049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUY4"/>
    <dbReference type="GeneID" id="28815775"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_234239"/>
    <dbReference type="InParanoid" id="A0A194WUY4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267481" evidence="2">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22306" checksum="81BCA1F4C7326AFB" modified="2016-10-05" version="1">MMMMMMLLLTTISDMSFGGGDDDAIVVLPRRFIWSSYSTVQSLSSFLLLKLFHTVPGRPLFSFVELPPSHARRSFPGSGPPSLPRLLLPSGSFLSLGVFYLLFPVAAAVPVPTYVSLFQRGDAYQTGPALYRLRQDSAGDGLAQAKDRRLHTKSTGAPPPVPTPLSCCDYSSYCTIFWLCPVFTTVLFSYCLYRALPNPPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY34</accession>
    <name>A0A194WY34_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_195265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067195.1">
        <property type="nucleotide sequence ID" value="XM_018205732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY34"/>
    <dbReference type="GeneID" id="28815458"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_195265"/>
    <dbReference type="InParanoid" id="A0A194WY34"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="156" mass="17572" checksum="8AED93E85CE36470" modified="2016-10-05" version="1">MYARDVQKLSGFHIRWVLHHVMLSVARISTSSSFLSQNQSPHLHHQQPSYHHPLGLPYLPYNTLTRASGFEAICTVVNAKMGMLSFLQQAKQNRMPGGKPGLPNIRSCSNKLFTRLQELDRTTQTGFRSLACLSFGAVRITNRDRVPHCLQKGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYL9</accession>
    <name>A0A194WYL9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_200309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067416.1">
        <property type="nucleotide sequence ID" value="XM_018205780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYL9"/>
    <dbReference type="GeneID" id="28815506"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_200309"/>
    <dbReference type="InParanoid" id="A0A194WYL9"/>
    <dbReference type="OrthoDB" id="3562711at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267609" evidence="2">
        <location>
            <begin position="27"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="372" mass="39366" checksum="FB478322C493CD1B" modified="2016-10-05" version="1">MAIAMQRTTFHQLLALISVLFQCVLCLPGGCGGTLEILDISSPTYNDTVWACAGIERSSIFGGDALLLAASNQDNVTNCADYCATTSFPDGLMAGIWDSDNSTCECWYIGDLNYYDLPAASPGVTFIDFFEAWNPGGRPSKAQNWGVFTCPAGAESGWADAGNAAYCGPLTLEPAQPALAELGIIGDCWGFCLEYPGVEWVLSRSPSDCNCYGDLAGLKVTLNYTPTDFVIDYYDFEPHSTSSSTFVTTKTSPSTSSHSTKSSTSVASRRSTTSALRSTTSPVTRSTPRSTLKSSLRSTSKSSSHTTIKSTTKKTSTSSEVTSPKSSSHSPTSTAKTISKTTSSKVILRTDTSSSKTSSPSKSSTHSTTKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZW9</accession>
    <name>A0A194WZW9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_753673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067517.1">
        <property type="nucleotide sequence ID" value="XM_018221283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZW9"/>
    <dbReference type="GeneID" id="28831009"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753673"/>
    <dbReference type="InParanoid" id="A0A194WZW9"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="663" mass="74249" checksum="59917AD1408C2082" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X013</accession>
    <name>A0A194X013_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_721336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067649.1">
        <property type="nucleotide sequence ID" value="XM_018218635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X013"/>
    <dbReference type="GeneID" id="28828361"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721336"/>
    <dbReference type="InParanoid" id="A0A194X013"/>
    <dbReference type="OrthoDB" id="5386823at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="124" mass="13065" checksum="EABFB6B832DDAB37" modified="2016-10-05" version="1">MSEATNTKLMDTEPGGEQTQHVLLLVCSPLLSSLPNIYSIDSSSSGQNKKQDEADKSERGEKTAENIRYGEAISEHGFGGETVGNGGKADAADGFGEIEDQSIEGQQRRREQQGYEGAGSGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X049</accession>
    <name>A0A194X049_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_591537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067925.1">
        <property type="nucleotide sequence ID" value="XM_018209660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X049"/>
    <dbReference type="GeneID" id="28819386"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591537"/>
    <dbReference type="InParanoid" id="A0A194X049"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="473" mass="52766" checksum="3FF35B9AC9A5EC28" modified="2016-10-05" version="1">MPSFKRVAVIGAGPSGFAAVKALSDENAFDTIKLFERRDRVGGIWLYDPKPDVFPTSVSRRPKINAPPQQLPAFAEPLGEDIGARTGIYDTLDSNVGAEVMAFTHTPFPKDNSADSVRRYGSNNPTRPYQIIERYIEDGFKEYRHLLSLSTTVENVEKVGEEWVLTLRKANEPLRGEHKDYWWQEKFDAVVVATGHYNVPFIPAIWGIDEAVKALPHKFEHSKSFRSPDDYVGKKVIVVGGSISAADLVGDLAAIVQGPLYLSQRGRNELLDAAFTLPGVVTKPPIRSISANNGGTVEFQDGSTVKNFDKIIFGTGYRLSYPFLNPEPVTAQNRLAGFYQHVFKIGDPSLTVVGQVKAALSFRVYEYQAVAVARFLAGRAKLPSVEEQNDWETKRLAYKGPTNLFHEVKPDFADYFNWLRNFAGAPAEGTKGYELPAWDDGWGPLGLRILSLKDAYWNRLKREAHEGQIRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X055</accession>
    <name>A0A194X055_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_699328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067931.1">
        <property type="nucleotide sequence ID" value="XM_018217048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X055"/>
    <dbReference type="FunCoup" id="A0A194X055">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X055"/>
    <dbReference type="GeneID" id="28826774"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699328"/>
    <dbReference type="InParanoid" id="A0A194X055"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF75">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="281"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="518" mass="56530" checksum="18B90159BCDA1030" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X065</accession>
    <name>A0A194X065_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_753858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067617.1">
        <property type="nucleotide sequence ID" value="XM_018221297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X065"/>
    <dbReference type="GeneID" id="28831023"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_753858"/>
    <dbReference type="InParanoid" id="A0A194X065"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="241" mass="26799" checksum="4B32F26D47A51D27" modified="2016-10-05" version="1">MAKYDRVSSEDSSNEHLLPDDSSSLYSPVALRRSKGFGFSISTACLLVYCALSTTAMVIFMVAILNQLQPQSHDNNCQVNKVFKAAYGHNTALMSVDHKYDALWEVQDGQSQVLLLPDEDSGGELVPGAFSMFHQLHCLSSLRHAIQMAREGKDPGLDQKDNTHWPHCMDYLRKASIEFNNMQTILCWADSTIERETLLSNGSGSQTIDGTHDVRQCGDSRALIKTMRDQGKNVTTEPFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0F0</accession>
    <name>A0A194X0F0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_721378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067702.1">
        <property type="nucleotide sequence ID" value="XM_018218640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28828366"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721378"/>
    <dbReference type="InParanoid" id="A0A194X0F0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1067"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="326"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="658"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="940"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1487" mass="163628" checksum="DF43706175A68D74" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0S4</accession>
    <name>A0A194X0S4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_687159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068156.1">
        <property type="nucleotide sequence ID" value="XM_018215440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0S4"/>
    <dbReference type="GeneID" id="28825166"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687159"/>
    <dbReference type="InParanoid" id="A0A194X0S4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="590" mass="65254" checksum="ED695BC50D3E2D85" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1J1</accession>
    <name>A0A194X1J1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_590769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068416.1">
        <property type="nucleotide sequence ID" value="XM_018209612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1J1"/>
    <dbReference type="GeneID" id="28819338"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590769"/>
    <dbReference type="InParanoid" id="A0A194X1J1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="70"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ14061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="390" mass="42587" checksum="00A92F9E4147807D" modified="2016-10-05" version="1">MASKTFAKVEDVEIQLHELDASKEACDRTSASTYDGDARDNKTNAFIKEWDAPDNQENPRNWSALKKARHIIPVALLCLSVTAGSSMITPGVFAISYKFQVSHTAAILPLSLFVLGLAIGPMLAAPISETRGRGIVYKVSMPLYMLFILGAGFSNSFAGLLICRILAAMAGAPCLAVGAGTVADLFEPSKMAGPGALVVMAPFLGPCLGPVIGGFSATYTEYRWTQWSTIFLALAAYILVLPTSETHRGVLLKRKAKKMNRPPPEPELARKDAIKLLLTITLFRPIRMLVSEPIVLLYSIYNAFTFSVLFAFFEAYPFVFMGEYDFQIWQYGLTFLGIGIGVLLGALGAILVDRLVYQKIVKEGGDRIRNRGPEQRLYIGMIGDLCLPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1Q6</accession>
    <name>A0A194X1Q6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_650762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068127.1">
        <property type="nucleotide sequence ID" value="XM_018212122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1Q6"/>
    <dbReference type="GeneID" id="28821848"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650762"/>
    <dbReference type="InParanoid" id="A0A194X1Q6"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="12">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="13">
        <location>
            <begin position="315"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55486" checksum="4A7E7593C868BA3D" modified="2016-10-05" version="1">MFASSNTSTLLNCIIRIIRSWLLCKAPLFNSVGQSLVFAAYLLINVALTLQNLDLDVVHNWAKRLGWITTCNIAFITFLALKNTPLAFLSSYSYERLNILHQAAGYCTIIFTIFHAIFWIWAGAESGSLHIFLELDNIMGIVAGCAMLVILFTAGILRHFIYEAFYVTHITMFMLVLIAAAMHHPDLSSKSTYITIFAACIWFSDRLLRGARTLWYSMSNRATIHALPLGGVRIIMRRTPWRAVPGSHVFLWIPKARASETHPFTIVSTNPLELVVSPHDGFTRDLSSLASSIPGISLRASCDGPYGTLPNFALFNHLVLLAGGSGATFTFGVALNLIRKMTGVRMRLVIHFIWVVRDSEMQSWFEKELAELSACPAMNLSIYVTGAGNTTTNPKDTKEDSDATITQAQNLENLNTDPEKLEPDTHSPSTSESAQSTLPVILGRPDINAIVRSIVFGTEEQERTIVAACGPNGLMRDTRAVVGDLLVTSGRSVELHCEQFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X300</accession>
    <name>A0A194X300_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_650439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068916.1">
        <property type="nucleotide sequence ID" value="XM_018212106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X300"/>
    <dbReference type="GeneID" id="28821832"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650439"/>
    <dbReference type="InParanoid" id="A0A194X300"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="373" mass="42845" checksum="B95C58443AA6A8BD" modified="2016-10-05" version="1">MPKTVDGIESAAVHDAIKLLTNNLVNIKDTTGKFLMTIPDGRVIDTKGWNENNWEWTHGVGLYGLYKYYSLTGDVSTLKIVEDWFRDRFAAGGTTKNINTMAPFLTLAYLYEETNNQTYLPWLDSWAEWAMYDLERTEYGGMQHITYLTPNMQQLWDDTLMMTVLPLAKIGKVLGRPHYVEEAKRQFLLHINYLFDPQTGLWFHGWTFEDGRHNFARARWARGNSWITIVIPEFIELLDLPEHDPIRIHLIDTLEAQCRALKKYQDASGLWRTLLDHDDEGSYVEASATAGFAYGILKAQRKRYIGKEYEEVASKAVKAVMGQIDSQGELQNTSFGTGMGDSLQFYKDIPRTSMPYGQSMAIMALGEFLRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3J9</accession>
    <name>A0A194X3J9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_671753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068757.1">
        <property type="nucleotide sequence ID" value="XM_018213237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3J9"/>
    <dbReference type="GeneID" id="28822963"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_671753"/>
    <dbReference type="InParanoid" id="A0A194X3J9"/>
    <dbReference type="OrthoDB" id="5332316at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="385" mass="44078" checksum="B1C732D52A2CF2CB" modified="2016-10-05" version="1">MQQRKRPGRPKPHWPKSDSALSLFDELFPEEMLAKSSEQTLAEQRLDKLPAFNWTPDINVGDYPEEKIDTYNQIPQPDPLNPATLPTEYTPVTNISQLREGMRQTMLEDEQSPKGPSVLVLNACSKNLEESDFFRISPKGEHIEGWKSGLLKVIPSRDNKSFEPLGSYFLLFSSDAAARAYLDQTMRLHTLTRLEQTQKQARFPLPPGYLKEEENVQSLLKSFSLVPGFVKLSMRMLSRPYSTRVQTLINEGGPVAVASKEAKAQHMVLFTTDRSHITHGDVADALRQDGKRRNMHWNLAGDRRTSIIRIQNKAREEGDNSVTQKRGKLGGRRTYDGPGRFIITFKDSHEARRFVREWHCRPLHIQQDIRAEDEPPPIVNAEILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3U0</accession>
    <name>A0A194X3U0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_736525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068847.1">
        <property type="nucleotide sequence ID" value="XM_018220131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3U0"/>
    <dbReference type="GeneID" id="28829857"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736525"/>
    <dbReference type="InParanoid" id="A0A194X3U0"/>
    <dbReference type="OrthoDB" id="10558630at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="81" mass="9239" checksum="D8DAC609164619C4" modified="2016-10-05" version="1">MPQSQHSQRSLFSLSTFVTTTKKTQKRQPSGTMEQYIYDTDNIPDHLIQGISPLKDERILKAQKAIAKVDKVFKECNDVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4K8</accession>
    <name>A0A194X4K8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_686584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069354.1">
        <property type="nucleotide sequence ID" value="XM_018215317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4K8"/>
    <dbReference type="FunCoup" id="A0A194X4K8">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X4K8"/>
    <dbReference type="GeneID" id="28825043"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686584"/>
    <dbReference type="InParanoid" id="A0A194X4K8"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="970" mass="108057" checksum="7DD0890B2EC515F9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X5H2</accession>
    <name>A0A194X5H2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Class I/II aminotransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_686184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069783.1">
        <property type="nucleotide sequence ID" value="XM_018215227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X5H2"/>
    <dbReference type="STRING" id="149040.A0A194X5H2"/>
    <dbReference type="GeneID" id="28824953"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686184"/>
    <dbReference type="InParanoid" id="A0A194X5H2"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="88"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="486" mass="54639" checksum="3351F359DF651B17" modified="2016-10-05" version="1">MSFKNRQFSMNRSTGSPRLSTKIQRRFSTHNPDANETNSKIHRQFRNAHEGHKSHAGLDPTRASTGVIWCTERAYEHGFLENPEEWANLGQGAPEVDDEIEGSFHRPTEIDITMAGREYGPTAGIKGLRAAVANLYNVHHRAGKASQYSWENVCIVPGGRAGLIRIAAVLNNAYLGFFIPDYTAYNEMLSLFKNFAAIPSPLSEEDGYHIHPDKIAEEIARGTSVILTSNPRNPTGKVVKNPELAEIQNLCRDRATLIMDEFYGGYNYTSNCDGTTISSAENIEDVDEDDVLIIDGLTKRFRLPGWRIAWIIGPKEFIKAIGSCGSYLDGGANVPFQEAAIPMLEPNKVLKEMQAIQRHFKDKRDYVVKRLRDMGFHIKTVPDSTFYLWLDLEGLPEAIADGLNFFQACLEEKVIVVPGIFFDLNPSKRRDLFDSPCHHFVRFSYGPKMETLKMGLDGIERVVNKFKKDGKLMKSDDDTVAEEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X673</accession>
    <name>A0A194X673_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UPF0160 protein C27H6.8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070030.1">
        <property type="nucleotide sequence ID" value="XM_018215120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X673"/>
    <dbReference type="FunCoup" id="A0A194X673">
        <property type="interactions" value="1226"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X673"/>
    <dbReference type="GeneID" id="28824846"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685628"/>
    <dbReference type="InParanoid" id="A0A194X673"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="350" mass="39017" checksum="11A3F131D08587F8" modified="2016-10-05" version="1">MAETAAKRLKTSPVTIGTHNGHFHADEALAVYMLRLLPTYHSSQLVRTRDPALLQTCHTVVDVGGEYDASANRYDHHQRTFDTTFPNRPTKLSSAGLVYMHFGKAIIAQHLGVPEEAKEVDIIWGKIYESFIEALDAHDNGISAYDTKAIKAAGIEKKFSDGGFSLGAMVSRLNPNWNDPTPSDPVEAQKVEDEKFLVASTRMGEEFSRDLDYYTRSWLPARDIVHAAYAKRLEYDPKGRILVFDGQSVPWKDHLYTLEAEEGGEAQVLYVLYPEKPTPDAKWRIQCVPVSKDSFESRKPLPEAWRGFRDEKLDEVAGVIGGVFVHAAGFIGGNKTFDGAKAMTLKSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X6W0</accession>
    <name>A0A194X6W0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_98879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070268.1">
        <property type="nucleotide sequence ID" value="XM_018223560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X6W0"/>
    <dbReference type="GeneID" id="28833286"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_98879"/>
    <dbReference type="InParanoid" id="A0A194X6W0"/>
    <dbReference type="OrthoDB" id="3531891at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="303" mass="34276" checksum="CF8672C5D88C1FEA" modified="2016-10-05" version="1">MQLNKQKTILVVSEKDNTDEPSRRTGDIWTQLVAHLRSTAPPRSILHPFKVLQADPWKNFKIDIQLEKAVHGYLTPDRQQRASLLVFGVQLVSQRRKTPFKRLTLEAKLMETQGSPSSRPEVLAHAPFVFEEALKRCEIEVQNARRVKDHAAASFNVGGAKIGIGREVTRSRTSRSIHKYFAKGSSATTVDDDGKCSGIWWNVKQSTIPDAQDDAGIDPNYCFAILLTRERNDKAVFKVKINLEAHAGLSYLLENKFSHVIHVKDLNVDPRTWHVGPCRSIDRERLGHFLKPENLVALTKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X717</accession>
    <name>A0A194X717_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069952.1">
        <property type="nucleotide sequence ID" value="XM_018219941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X717"/>
    <dbReference type="GeneID" id="28829667"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734757"/>
    <dbReference type="InParanoid" id="A0A194X717"/>
    <dbReference type="OrthoDB" id="10499034at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267963" evidence="2">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="270" mass="30277" checksum="013EEA9DE470C5C2" modified="2016-10-05" version="1">MKAERLQQVLVSLKFLLLLAVLGSHASEFFSEWQIWKNEQHVSKPLPGSQEIRTYMHAVMVPNYSNMSSGRSSVEKSAWFELADNDLREISRLIQSHDEQAFSTGLERLEYRVAQSQQASQSLQDPSYRAPKWQLKQWQEQVRKGPPVLTGIAKHLKDPSRRPHAMQMLANICDDRFSAKTFKPPVPVQQTNTSPQGRSSRESKPAKPLAVAVVPQVQVRAHLQGKEFGLGYDPGEYVEEFVTPANMFAPSVVPLTASKRVGAKTPSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7R5</accession>
    <name>A0A194X7R5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_646542</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070499.1">
        <property type="nucleotide sequence ID" value="XM_018211928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7R5"/>
    <dbReference type="FunCoup" id="A0A194X7R5">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7R5"/>
    <dbReference type="GeneID" id="28821654"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_646542"/>
    <dbReference type="InParanoid" id="A0A194X7R5"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="212"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="240"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ16144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="544" mass="60562" checksum="638DAE51441AC593" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X813</accession>
    <name>A0A194X813_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_542666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070297.1">
        <property type="nucleotide sequence ID" value="XM_018208200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X813"/>
    <dbReference type="GeneID" id="28817926"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_542666"/>
    <dbReference type="InParanoid" id="A0A194X813"/>
    <dbReference type="OrthoDB" id="3638982at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ15942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="14194" checksum="AD9B3E4D3FA96A78" modified="2016-10-05" version="1" fragment="single">TSSTGATCDSAVMALASGIQSNIDDQNNELTTVTALGNVLAQNPLDSTLYSATQSSLLGFVTKGIAIRQNNQKIAPAGNPAIAGLATVAIAQMTELNLTMSLAVPASGSVDVGTANKTVEALKGDFKGGIVQNMKNLAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X919</accession>
    <name>A0A194X919_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_747791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071020.1">
        <property type="nucleotide sequence ID" value="XM_018221135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X919"/>
    <dbReference type="GeneID" id="28830861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_747791"/>
    <dbReference type="InParanoid" id="A0A194X919"/>
    <dbReference type="OrthoDB" id="10521583at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="254" mass="29750" checksum="95D335A193CEA3B3" modified="2016-10-05" version="1">MSTNNTPGTNVPTPRIVPFRLALPYDGDPKPFTQLTHEIKWTPSPPQIGTLIEDMAYLPNAKDHDLEEFLRDLLKAKCSVDIGHREESGQCRGRLALDWQCFDHNEEWYEGDIGKDMREIFRRMFRLGLRELVLVIGQLEVMELVKQQDPKSFILVRPDIDGTYAEFEDDCYEWRNFLRKSNMEPWEGEKTFQEVEEGIKRAIAGSESAWRDFCGPEIGRMDHETFYRFYKKWICGKGTEEEALKIAFMELREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X992</accession>
    <name>A0A194X992_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_782019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071093.1">
        <property type="nucleotide sequence ID" value="XM_018222539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X992"/>
    <dbReference type="GeneID" id="28832265"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782019"/>
    <dbReference type="InParanoid" id="A0A194X992"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="296" mass="33031" checksum="BF1D5817EBD71F5F" modified="2016-10-05" version="1">MSEAPQSRQLDQETGNTPAPQHTKIDWSNLPENVFKSMEARTASTCAAYLLPTLKEMKAENPQLTLLDVGAGSGSISAEFAQLVGPNGHVTAVDLNPGVIPRAKVVAEQWRVSNISFQTADAYKLAFDDETFDIVHCHQVLVHCKNPWEILREMLRVTKLGGVVAAREGDLETEVMWPPLPGLLKFHHDFEVKLITDRGGHKNAGRQLLSWALRAGAKRDQITTSFGTWTYTEPEDRKMWATSMMEVALGPMLREKNVKAGVAEAEMDEMREAWAEWMNLDEAVMAQLHGEVVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9H6</accession>
    <name>A0A194X9H6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_585643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071134.1">
        <property type="nucleotide sequence ID" value="XM_018209332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9H6"/>
    <dbReference type="GeneID" id="28819058"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585643"/>
    <dbReference type="InParanoid" id="A0A194X9H6"/>
    <dbReference type="OrthoDB" id="3508416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24733" checksum="96AFBDB6013EEAB1" modified="2016-10-05" version="1">MALEAAGVTSRDLARKPLGSSYQGDVFAGSYLHRVNGLPDHLNSAIWMMKLRPDTQHSQIFDIIQCGSVWSLHLKLPTADHSTMAAQLAFVSPQAAAIFMHHYRTYGIQIAGNWISCIYDKHGSPGHTTSETRVLRIEGPATVMNPQFWDAKFRSACSFQLDRWGYLQCDTPGKLRMEFRFSRVDGQAQTCRQMIERVLVHYGISVWYGPDPCGQIGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA90</accession>
    <name>A0A194XA90_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_71708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071440.1">
        <property type="nucleotide sequence ID" value="XM_018218316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA90"/>
    <dbReference type="STRING" id="149040.A0A194XA90"/>
    <dbReference type="GeneID" id="28828042"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_71708"/>
    <dbReference type="InParanoid" id="A0A194XA90"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="85" mass="9529" checksum="71480BDEB0B52D5A" modified="2016-10-05" version="1">MGGGGKIPYPKHVWSPAGGWYSQPSNWKANTAVFGVVIVGITAMMWKLSADREVRTRFPEEGRFFPSRYWSKQIIEHEKSAKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAV4</accession>
    <name>A0A194XAV4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_616525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071247.1">
        <property type="nucleotide sequence ID" value="XM_018210769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAV4"/>
    <dbReference type="GeneID" id="28820495"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_616525"/>
    <dbReference type="InParanoid" id="A0A194XAV4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ16892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="291" mass="32768" checksum="8E23C10F37518ECF" modified="2016-10-05" version="1">MTASELTLHSALQLLNSPIKIPLLGFGVYDSHTEVCIASIQTALKSGYRHIDTAHPRRSYGNEEEVGRAILSSGVSRSELFITSKIRVPADGAQDHYSSILESIQKIDPGPEGYVDLFLIHSPKPPTNVRMRVWFALERLLAERRVKSIGVSNWDVSRIEEMKTWGKRDGAVWPPMVNQIELHPFCQQKEIVSYCHTHNIAIEAYCPIVRNQRANDPTLCSLAEKYRVSTPQILIRYCLQKNWVALVKSDTPKRIVENSDVYGFELTGEDMRLLDGLNEGAAGAIVWAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB05</accession>
    <name>A0A194XB05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_684400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071679.1">
        <property type="nucleotide sequence ID" value="XM_018214872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB05"/>
    <dbReference type="GeneID" id="28824598"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684400"/>
    <dbReference type="InParanoid" id="A0A194XB05"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30296" checksum="EDF5E09272E0CEFB" modified="2016-10-05" version="1">MDTDDANKPPSPPASPPMPPQSRRLFDGTISPLTPSSFEEIQSCPCLESNCNLLSKQKSSCEHARFSNQYTFDASPKRPREEDEDKQTDKTPRGEKRLRLIEGRCQTSEDTTTHDSELDIEMEDAFKSFALDTPMTNTEMEEDIPDAFASKRKRDTAADEKHASKRAKTAESHAAFYSNETRNIAKSVGIPPAKTNRAGSFQDLNCGSKFVMEEEQGSRSKGTRNARLDQSPESERKRKGEEDGGICSKGYKKAKVEYELLFEEWDEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB51</accession>
    <name>A0A194XB51_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_554607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071748.1">
        <property type="nucleotide sequence ID" value="XM_018208350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB51"/>
    <dbReference type="GeneID" id="28818076"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_554607"/>
    <dbReference type="InParanoid" id="A0A194XB51"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33974" checksum="A4BF64378B99CA6F" modified="2016-10-05" version="1" fragment="single">NTASAYVIPRMVPRNPCALGDWLTNDLRDFSHLFDRSKFKANMAIVCPQMKIYDDINDLEGQDWALTSTELSPKSLDSEVHHDYTTAHASLWRSLFDNFLISSNVVFSPAQPALLEIHDAFLEWPIQADTPAIVATFGRMYQAPSPIRQIAVKVLTQLKTQHSLNISLSRGAIFSDSSVSYFACHLRTEGDAMGNFGSYDLQAGTYLQIASTRGYKIMYVTSGDIGEVERIRAQALTDHGITVVTKYDLLKGEDREALRQLSWDQQAMIDLEVLLRAGYFAGVAASSFSYNAAVKRHTIFMSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBG4</accession>
    <name>A0A194XBG4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_684533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071858.1">
        <property type="nucleotide sequence ID" value="XM_018214901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBG4"/>
    <dbReference type="FunCoup" id="A0A194XBG4">
        <property type="interactions" value="1094"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBG4"/>
    <dbReference type="GeneID" id="28824627"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684533"/>
    <dbReference type="InParanoid" id="A0A194XBG4"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ17503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="414" mass="43870" checksum="4A27FBE0BC9B3FAF" modified="2016-10-05" version="1">MADEVNHDELISQFVNITGASPADAQQYLAANRWDLSGAAAEYFTTLEEGTADAQGGENDPQEPEAYTGPRTLDGRPAPQSIPSVASSSRAPPKKRGGIATLGTLGQSSSGPAGGHGHAHDDDSDDEDYEPGEEPRDLFAGGEKSGLAVQDPSSRDPRRVVRDILEQARANVQRPTGESSSSAPPSRFRGSGQTLGGDDTPSQTIPDPHPQAADPGPAETRVLHLWADGFSIEDGPLRRFDDPQNAADLQMIRQGRAPLHLMGVRPDQPVDVQLIKHDEPYKAPPKVYKPFSGSGQRLGSPTPGGSTATSTPAPVTAPAATSSPSVPEQEVDSSQPTLSLRLQLANGTRLPARFNATHTIGDVYGFIERAYPGSSARPWVLATTFPNKDHTDKSLALGDVSEFKRGGTAVQKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBT4</accession>
    <name>A0A194XBT4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_74048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071572.1">
        <property type="nucleotide sequence ID" value="XM_018220595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBT4"/>
    <dbReference type="GeneID" id="28830321"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_74048"/>
    <dbReference type="InParanoid" id="A0A194XBT4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="155" mass="17183" checksum="0C6A4743681D34AD" modified="2016-10-05" version="1">MRSRIDSSALRAACAFSADCAICALSGICAIYVPTSSLSRLHSPMILRYTPFSLSLCFLSTQLHNQRRLNSNLKFRRFRTHQTEYGCTQLQNSFLILCDSRLYLHVKLGLVENAEGRGMKVGTRECIGICKAAMNGNGCPPNTALTFKSRTLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC10</accession>
    <name>A0A194XC10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_781849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072055.1">
        <property type="nucleotide sequence ID" value="XM_018222519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC10"/>
    <dbReference type="GeneID" id="28832245"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781849"/>
    <dbReference type="InParanoid" id="A0A194XC10"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="560" mass="64247" checksum="484599C7A6A5A8FA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XC66</accession>
    <name>A0A194XC66_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_669042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072106.1">
        <property type="nucleotide sequence ID" value="XM_018213063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XC66"/>
    <dbReference type="GeneID" id="28822789"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669042"/>
    <dbReference type="InParanoid" id="A0A194XC66"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="615" mass="70544" checksum="7C019ADC7240F01D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCQ5</accession>
    <name>A0A194XCQ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_668157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072308.1">
        <property type="nucleotide sequence ID" value="XM_018213024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCQ5"/>
    <dbReference type="GeneID" id="28822750"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668157"/>
    <dbReference type="InParanoid" id="A0A194XCQ5"/>
    <dbReference type="OrthoDB" id="10645232at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
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        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26823" checksum="24F1505B55C90E71" modified="2016-10-05" version="1">MDDAGDRQRPTRRLIVHALRHTEAEHKVTKTTNIEICNPRLTQRGQEQCETIRQTFKRVLPSKPKIFSSPLYRALETIFRSFPSFIDAETGTIVRLLAELQSLDDGRNGTASSLHKLSEDWGFEVSFKELRIGYNRKDVKETAAWATIPGRRAFLNTLLEQIFEEMTEGIEEVVFGTHSSIIREVFYLDEDDDYRANRRQFLHSFEWDSDNRKLIPLSQKQVAAYRDTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDH0</accession>
    <name>A0A194XDH0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exocyst complex component Sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_684155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072580.1">
        <property type="nucleotide sequence ID" value="XM_018214825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDH0"/>
    <dbReference type="FunCoup" id="A0A194XDH0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDH0"/>
    <dbReference type="GeneID" id="28824551"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684155"/>
    <dbReference type="InParanoid" id="A0A194XDH0"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="755" mass="87210" checksum="59364CB4A1573A6E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDP0</accession>
    <name>A0A194XDP0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_644367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072655.1">
        <property type="nucleotide sequence ID" value="XM_018211835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDP0"/>
    <dbReference type="FunCoup" id="A0A194XDP0">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDP0"/>
    <dbReference type="GeneID" id="28821561"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644367"/>
    <dbReference type="InParanoid" id="A0A194XDP0"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ18300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="421" mass="47883" checksum="471B8C501478B0B4" modified="2016-10-05" version="1">MSRCDSEKLAPQHKSAFFSFIKSLATFKGDLASLTAPPFLLSPQSIIEFSAYWAEQPCLFVAPSKEEDPEKRALLVLKWFLSTLRQQHNNKDENGKKKRMKPLNPFLGELFLGKWVDDCGTTNLVAEQVSHHPPITACNIWNDTHGVRLQGHVAPKAYFSTTVHIDRKGYSVLHLDKYDEDYLITMPKIHIEGIMTGSLCPELSGATYIRSSSGYTAKIDYSSKGWLSGKKNSFVATLFHDDKQNEPLYTAEGQWSGDFCMKKVATGEVVESFNVDSVPRTPLTVTPVEHQHPLESRRAWQNVADAIHRNDIFAVGHEKTKIENEQREMRKIEKVEGREFPRRYFTKAKQDLVAKSLTEGMKRHASMQGEMEGHHGVWMWDEQKYRRVENNRAQGIKSPMRTRFDSGIGGILLDPDLVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDT9</accession>
    <name>A0A194XDT9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_733025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072705.1">
        <property type="nucleotide sequence ID" value="XM_018219753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDT9"/>
    <dbReference type="STRING" id="149040.A0A194XDT9"/>
    <dbReference type="GeneID" id="28829479"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733025"/>
    <dbReference type="InParanoid" id="A0A194XDT9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="237"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="700" mass="77623" checksum="4E16E9AB32975655" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFQ4</accession>
    <name>A0A194XFQ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_509554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073353.1">
        <property type="nucleotide sequence ID" value="XM_018208062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFQ4"/>
    <dbReference type="GeneID" id="28817788"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_509554"/>
    <dbReference type="InParanoid" id="A0A194XFQ4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28634" checksum="7B8D1E81A5D8CC60" modified="2016-10-05" version="1">MGIIKHSLNPGLEAYRDIKTEPPAFAQENKAISQGRAGCEDTECFSEKLKKMDHQRPAPCVRLEPAPMIDTAFVQPVISSSQQKVKHALGNSDQTQEPVPPAQSPLRMIPRPRILREPRQRSFLISDPLNSNRAQIMISADSQAMEPLIAHYSDDRQSPFDAPRISNQGPFLGLDDLNDFSTFVQPPQTMYDYDNHKFCSATEDISRGGTDVYVDSHDFEGLLSFESSLPDANGPIKHVRDMNKGLKGRYEFDGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHM7</accession>
    <name>A0A194XHM7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_456999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073989.1">
        <property type="nucleotide sequence ID" value="XM_018207645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHM7"/>
    <dbReference type="STRING" id="149040.A0A194XHM7"/>
    <dbReference type="GeneID" id="28817371"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_456999"/>
    <dbReference type="InParanoid" id="A0A194XHM7"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="595" mass="68152" checksum="CCEFCA1F2203B654" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHS4</accession>
    <name>A0A194XHS4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_773580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073677.1">
        <property type="nucleotide sequence ID" value="XM_018221941.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XHS4"/>
    <dbReference type="GeneID" id="28831667"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_773580"/>
    <dbReference type="InParanoid" id="A0A194XHS4"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268265" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1323"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="116"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ19322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1413" mass="154019" checksum="25C0E0282CB9434B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHV9</accession>
    <name>A0A194XHV9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_641076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074160.1">
        <property type="nucleotide sequence ID" value="XM_018211698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHV9"/>
    <dbReference type="FunCoup" id="A0A194XHV9">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="GeneID" id="28821424"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_641076"/>
    <dbReference type="InParanoid" id="A0A194XHV9"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ19805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="329" mass="37995" checksum="E4E667FCB720A5CE" modified="2016-10-05" version="1">MRKGTIVFLVVNFCIIGLLVNAFSTLIGLLFEDGAADAITRAEIPAPGSDLIENRTQMIPKIIHQTYINASIPAQWKPGQQSCIDLHDDYEYKLWTDDKSREFIEAEYPWFLTTFDSYPFPIQRADAIRYFVLHFYGGIYIDLDDGCNRRLDPLLSYPAWVRRTVPTGISNDAMGSIPQHPFFNTVIDSLAGYNRNWFMPYITVMYSTGPLFLSVIWKEYLRVDRPPMEHVRILMPDEYKGFAWSFFNIVKGSSWHGKDAQTIFWMGKHWLLLTVSGFAIAGVVGACLWSLWNMWVMKGKRSSPGRKRMGLWRRISGGKERYELLDRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI55</accession>
    <name>A0A194XI55_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_462857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074198.1">
        <property type="nucleotide sequence ID" value="XM_018207698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI55"/>
    <dbReference type="STRING" id="149040.A0A194XI55"/>
    <dbReference type="GeneID" id="28817424"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_462857"/>
    <dbReference type="InParanoid" id="A0A194XI55"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268276" evidence="9">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ19843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="439" mass="46152" checksum="B180B752F186D9AD" modified="2016-10-05" version="1">MQFSSLLGALALASCGVVAQNVTYCPSGNVCYAVNVPATTASSGSGDIYFQITGPSTLSWIGLGQGTSMTGANIFMIYANSAGDNVTLSPRLGSGNRQPESDTTTDVTLLGGSGISNGVMTANVRCSNCNTWTGGSMSLTDTNSNWIWAYKTGSVISSDDVSANLAQHSNYGETTFNLQNAGGGSSSNPFLATTAMSTSSGNNSGSSSSGSSSVGGDSMPADYANVRMAHAILAPIAFVLFFPIGAMAIRLLSFPGLVWVHAGWMTFTYIIVLSSMGMGVWMAVVSKQLDQYHSIIGLVVVGCLLLQPISGFTHHLLYKREGRPNAATYPHIFWGRAVITLGIINGGLGLQLSGNTVKGEIAYGVVAAVMWLLWMIVIVLAFIRSRNKPEGETGEAVFEKPNDSTERMRISQSVHQQDSPLRLSFSGDNIGLAPKPTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI92</accession>
    <name>A0A194XI92_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_579655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074295.1">
        <property type="nucleotide sequence ID" value="XM_018209018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI92"/>
    <dbReference type="FunCoup" id="A0A194XI92">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XI92"/>
    <dbReference type="GeneID" id="28818744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579655"/>
    <dbReference type="InParanoid" id="A0A194XI92"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="292"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="804"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="665"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="872" mass="97570" checksum="F86DA78530AD36A4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIX5</accession>
    <name>A0A194XIX5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_779631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074072.1">
        <property type="nucleotide sequence ID" value="XM_018222313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIX5"/>
    <dbReference type="GeneID" id="28832039"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779631"/>
    <dbReference type="InParanoid" id="A0A194XIX5"/>
    <dbReference type="OrthoDB" id="3445164at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="24398" checksum="93E324991A8AE5DF" modified="2016-10-05" version="1">MSYYYSSYHPYKAPLEPPRRRWGLRRTSNSLKPSHWQARPSISAALFYHTPRTHTSRSYYHAPPESTRHHHHRSRLTDLPNELKLNIIEVLDPVSSACLGVSSRKMYPLHRSVHKKVGLYDQNVDSRVPLAFKLKNWVPKDYALDWQSEKFVKRERLAALEKERKRERESYWDERRRLWVWDVDYEDRDRGERRHRRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKW6</accession>
    <name>A0A194XKW6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_417116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018207379.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_417116"/>
    <dbReference type="InParanoid" id="A0A194XKW6"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="93846" checksum="ADEBD6A64B16B972" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL26</accession>
    <name>A0A194XL26_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Golgi apparatus membrane protein tvp18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_610634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018210557.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194XL26">
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    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL26"/>
    <dbReference type="GeneID" id="28820283"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_610634"/>
    <dbReference type="InParanoid" id="A0A194XL26"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="148" mass="16158" checksum="94C01886710AECA7" modified="2016-10-05" version="1">MTIAEEFATRNFSIYGQWTGVICIFLCFALGISHLFHVSIMILFGALCLASSFLIIFIEIPLLLRICPTSAKFDTFMRRFTTNYMRAGIYLAMGIVQWLSIIHEASSLIAAAIMLTLAASFYALAGVKGQGFVGSKTLGGQGVAQMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL58</accession>
    <name>A0A194XL58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_665390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075268.1">
        <property type="nucleotide sequence ID" value="XM_018212838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL58"/>
    <dbReference type="STRING" id="149040.A0A194XL58"/>
    <dbReference type="GeneID" id="28822564"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665390"/>
    <dbReference type="InParanoid" id="A0A194XL58"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ20913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="688" mass="74339" checksum="67A6B109679E7926" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN03</accession>
    <name>A0A194XN03_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_694933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075861.1">
        <property type="nucleotide sequence ID" value="XM_018216737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN03"/>
    <dbReference type="STRING" id="149040.A0A194XN03"/>
    <dbReference type="GeneID" id="28826463"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694933"/>
    <dbReference type="InParanoid" id="A0A194XN03"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="577" mass="63555" checksum="1982ED9B07C176B4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN56</accession>
    <name>A0A194XN56_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_767633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075926.1">
        <property type="nucleotide sequence ID" value="XM_018221763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XN56"/>
    <dbReference type="GeneID" id="28831489"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_767633"/>
    <dbReference type="InParanoid" id="A0A194XN56"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="29503" checksum="F84F0315EFCDDEE9" modified="2016-10-05" version="1">MDLSRLYKQLPTELQLRVWEQTLEPRSLKIFDQSSRDKFFELYEDSSPPVVLQLWQRAVISRQYPDWRKAMSKLLSLETFSVISHEMMPKLDGENDKFKQAIERTLLSVQRENDDWQVPQVCVIRTGDVCPTRRRQTDQLDFVDFARGGVKEAYLLKVTRPRCSCSACAGRSALGLLSQGFPTARQILVWSKKDSQKPYTPHPSMFSIWPNDLATQAHGGAKFIVHDSTLVPASAMAILTFTSFMATTTLLEDLAALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNZ3</accession>
    <name>A0A194XNZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_577166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076154.1">
        <property type="nucleotide sequence ID" value="XM_018208873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNZ3"/>
    <dbReference type="FunCoup" id="A0A194XNZ3">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNZ3"/>
    <dbReference type="GeneID" id="28818599"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577166"/>
    <dbReference type="InParanoid" id="A0A194XNZ3"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012104">
        <property type="entry name" value="PHO85_cyclin_1/2/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016511">
        <property type="entry name" value="Cyclin_Pcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="192" mass="21900" checksum="0E577BB2356408EA" modified="2016-10-05" version="1" fragment="single">MSYPSRALNEAALETFIYRPVTSEMIAYLAFKASEVIQCEKSTEDSQLPPSPPQTPPHDDSTTDSPSLPSLERFITSLVRKSNVQVPTLMTTLVYLERLRQRLPPVAKGLRCTVHRIFLAALILSAKFLNDSSPKNKHWAEYSNVRGFEPFGFSKTEVNLMEKQLLFLLDWDLNISEDDLYTHLDPFLVPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP11</accession>
    <name>A0A194XP11_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_388761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076261.1">
        <property type="nucleotide sequence ID" value="XM_018207168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP11"/>
    <dbReference type="GeneID" id="28816894"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_388761"/>
    <dbReference type="InParanoid" id="A0A194XP11"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000925">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="49137" checksum="FEC3B9D452962E6C" modified="2016-10-05" version="1">MDIKQIVNSKGGQKGAAAVAAANGTAQDLHLLHSISQANSIPMSDTGSERGNSPHDSEHSRYSAPRYGQMGGINGGPNAMRYPSPTAMQNPLPMLQQPYRTDSSFDNGMMQQDTTRPPRQPGDATQKAFPCGTCGKGFARRSDLARHERIHSGHRPHVCEHPGCGKQFIQRSALTVHMRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYADCQKTFTRRTTLTRHQNHHTGTVEEAAAATAAALATRGGGSNRGGRPRSDGEQYSNNGSPMSTPSPGQRTMSASPNSELAPLNAMPRHPSEYQPYMSNSPLPGHLRTEYHMQNQPAQTTATFPNGMRPTSHPTGYGPPSILEPTPTMEQRQPGSANGSPHMSTVGWQSPSQNNMPSPSQSNGYVYPDPDPYGSGAIAQQQMYYPSSNTRQQNSGVDGYDVKPRISEMWTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPQ8</accession>
    <name>A0A194XPQ8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_665277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076501.1">
        <property type="nucleotide sequence ID" value="XM_018212830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPQ8"/>
    <dbReference type="GeneID" id="28822556"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_665277"/>
    <dbReference type="InParanoid" id="A0A194XPQ8"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29460" checksum="D875021A4B2682AA" modified="2016-10-05" version="1">MDTYINNRSRLTAIAAAPKKTVSKADKKTCTKDEPVIRKLGASADFSITISGITRNEMRERGKYYTKSMKLPGNIDLYNTPTYSVVKDLTQNMSVQARKAEIMDSKYWEIIVDVQSLSSGPSDPSILHKVQELTPLLNEIQKLIVKITLPSNFITTKADYMNSPTRRFLNRLVRQLRACRSMKWMRIVLVLPKGHPGFESNSPTPAFPAYYVIPFYALRFRSWRIQYQGLGQHTKFLNDFHVSEVDDRNNDFWAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQC9</accession>
    <name>A0A194XQC9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_664282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076820.1">
        <property type="nucleotide sequence ID" value="XM_018212756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQC9"/>
    <dbReference type="GeneID" id="28822482"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664282"/>
    <dbReference type="InParanoid" id="A0A194XQC9"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="182"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="33500" checksum="59D1F1AEB2CE580F" modified="2016-10-05" version="1">MATSASVEAQPEGTENKLRNTTSRERKTSRQERLDQIFDTARARKLKLDQDQGSGGLREQGEEDDPLSGSGCGSASSAKMDTAAAADNSSSADEETFVFRQRSGGETMNYQSTAVQPRPALRKEGSSRNNHPSTTAIRRRGRTHDPRTEGEHDDEDERESWWVRTLSNYGSLELENKGSVARDHLALERTFLAWLRTSLAFASIGIAITQLFRLNTTAASNGGDDPYKHLRQMGKPLGATFLAISIVMLGVGFHRYFESQYWIIRGKFPASRGSVALVAAITFALSVTSLVIVIVVEPGQFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQR5</accession>
    <name>A0A194XQR5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_297732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 120377</strain>
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        </source>
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        <source>
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        </source>
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</entry>
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                <person name="Mondo S.J."/>
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                <person name="Grigoriev I.V."/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <accession>A0A194XSA6</accession>
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        </lineage>
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSA6"/>
    <dbReference type="STRING" id="149040.A0A194XSA6"/>
    <dbReference type="GeneID" id="28823710"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679984"/>
    <dbReference type="InParanoid" id="A0A194XSA6"/>
    <dbReference type="OrthoDB" id="5235778at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
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</entry>
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                <person name="Kennedy M."/>
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    </dbReference>
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</entry>
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            <taxon>Mollisia</taxon>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KUJ23113.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSH8</accession>
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        </recommendedName>
    </protein>
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    </gene>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
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        <text evidence="10">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
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        <text evidence="10">Forms a conjugate with ATG5.</text>
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        <subcellularLocation>
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            <topology evidence="1 10">Peripheral membrane protein</topology>
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        <text evidence="2 10">Belongs to the ATG12 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:Atg8-family ligase activity"/>
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    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="15892" checksum="CB2370D5BAC8350F" modified="2016-10-05" version="1">MSSPSESPSRSSTPSDNTNAIPDAGLQEPDLPLTLASSMILTSLPRDAASALSAAGEFPKPKVTVHFKAVGSAPSVRNQVCKISSTQRFEAVVSYLRRTLQVGPTDSVFLYVNSSFAPALDEIVGNLHRCFKDSNDRLIVSYSMTPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSP2</accession>
    <name>A0A194XSP2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_169684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077516.1">
        <property type="nucleotide sequence ID" value="XM_018205557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSP2"/>
    <dbReference type="STRING" id="149040.A0A194XSP2"/>
    <dbReference type="GeneID" id="28815283"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_169684"/>
    <dbReference type="InParanoid" id="A0A194XSP2"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="303" mass="32773" checksum="6B7427B4D41C8912" modified="2016-10-05" version="1">MALEQIDTTMKPRSFSTLRCLQHENPLGLPRTGSIPRMQRGLPERRKIKDVKKVIAVSSAKGGVGKSTIAVNLALAFARRGLRSGILDTDIFGPSIPTLLNLSGEPRLSPNNQLIPLSNYGVKSMSMGYLVGDQAPVVWRGLMVMKALQQLLHEVDWGGLDVLVLDMPPGTGDTQLTITQQIVLDGAVIVSTPQDIALKDAVKGINMFKKIKTPILGMIQNMSLFTCPHCHNSTHIFGAQSGVTKACEKHGIKFLGDIPLHASICDDADRGKPTVVSEPESDRAKAFMAIAEEVGTKIELFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSX7</accession>
    <name>A0A194XSX7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_728015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077601.1">
        <property type="nucleotide sequence ID" value="XM_018219222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSX7"/>
    <dbReference type="GeneID" id="28828948"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728015"/>
    <dbReference type="InParanoid" id="A0A194XSX7"/>
    <dbReference type="OrthoDB" id="10488250at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="272" mass="31280" checksum="0589148793CE613D" modified="2016-10-05" version="1">MAQSSAPDDPTNGIYNQSITNTEDDGNNKDNQPISLIARINTLPKELRLKILKVEMEYSIVEDCLDGTQRPSIFAALKVNPDQTLYNEFLEEHNRSHAVVHIHNEEDFNKRKMKDLLQIKHLTIIYPLTFRAQKLTIQNKVETLFLDYRYSHNDIKKLSKQLHEQGYPNNNLYNDYIDKKSANIGPTNVLDVLKFLIAANQKSSGLRKLIVRTTGEKVKLVAILSSGLKLEPQKRFHKGFVYYICKKPNDSILTWDPRVSGSYYDEKLNSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT19</accession>
    <name>A0A194XT19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_713783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077646.1">
        <property type="nucleotide sequence ID" value="XM_018218076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT19"/>
    <dbReference type="GeneID" id="28827802"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713783"/>
    <dbReference type="InParanoid" id="A0A194XT19"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="238" mass="26943" checksum="869592E749200094" modified="2016-10-05" version="1">MASQVEGGIMMTEPLTDITSSIDDPYLTETLLSSDNPNVSEMRCTLEGECTTFCHPYPSPVPNPVEQQATDDLLSVCLRDVLSDRLTSWNTNAKQLFYYQDHQDNPIAGARFIRRTLLFAFTRLYDKKQEFRSRDLESQAKIFLGDWFDGDDMWGKHRVFPRSIDKSVFVAVAVGTRMRLWKCSKVADAANGVDITPLWGGVKEGDWGEYLEIGDSVEGVWLRNEIVKMLLGAGEMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTP2</accession>
    <name>A0A194XTP2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_713605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077422.1">
        <property type="nucleotide sequence ID" value="XM_018218065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTP2"/>
    <dbReference type="GeneID" id="28827791"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713605"/>
    <dbReference type="InParanoid" id="A0A194XTP2"/>
    <dbReference type="OrthoDB" id="3541652at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="200" mass="21954" checksum="C4C66BE8FFCF773A" modified="2016-10-05" version="1">MSTLVPHMCSENSLNSLLEPIMCCSEEDCTYSFGPACESCTLILKIREQRRQNLSTDHHSNKHSPKFDVNATGQLFFDGTSNDTSTKAAEDFNADLDSEFQISETRSFDAELPSSASSNLQTFSYPYTDTTSTTQPNSTETSISQTLDPWLSTLFDHTLAGHISGTAFVGGAEEQNPTENACPLCSKPVGDPRDQHLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU93</accession>
    <name>A0A194XU93_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077632.1">
        <property type="nucleotide sequence ID" value="XM_018213999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU93"/>
    <dbReference type="GeneID" id="28823725"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680054"/>
    <dbReference type="InParanoid" id="A0A194XU93"/>
    <dbReference type="OrthoDB" id="10473690at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29209" checksum="B36C7F11483E9511" modified="2016-10-05" version="1">MCTNTKITYLLCLHNISQFRSCRPIITFLLRRGRCETNSTEAFINDYCERCRHFWDRYSISEESRRARAADFRLESDYHGPITPSAVPSAGGKAWFFGFVKDEEEKPARDVSELKLRRKVDVGEASISDMTENKGKRRDSMDSGGTVWPSGIGEKDGDDESKRLGPDEYGNDSDVASDWSRGEGVIKPEEFDLQHLERQLCGSMEEEQGAEKRDQRLRPAAPMPGITLQRRTSMIHHYPAVVTIPPMRLLSLSVNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUA6</accession>
    <name>A0A194XUA6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_664023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077974.1">
        <property type="nucleotide sequence ID" value="XM_018212742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUA6"/>
    <dbReference type="GeneID" id="28822468"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_664023"/>
    <dbReference type="InParanoid" id="A0A194XUA6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="238" mass="26850" checksum="551DACAA173F9388" modified="2016-10-05" version="1">MTPFMSLNAIYLALAILLYLLGYFSFKPPKPLHRSVQLSALKRSLQTYPHFNKNKQDRDLFFKYAAHFLAEGSAPEIPEAQDYIEFDPPFAIFLSVVVTLILLGITALQCAFSAGLGEGAVIFSPSIDRWLAPTTLVLLRAGIVIVFALAGMMSWEFGWATRMRRTLGGIREVCLDGEICKCCGRGGDEVVGEKRREVQEERLSWWIQGLLGKDEDNAVEARKRMEEVIMPVIEKIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWM5</accession>
    <name>A0A194XWM5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_26160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078988.1">
        <property type="nucleotide sequence ID" value="XM_018206277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWM5"/>
    <dbReference type="GeneID" id="28816003"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_26160"/>
    <dbReference type="InParanoid" id="A0A194XWM5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ24633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10110" checksum="B4545C4D54074A2D" modified="2016-10-05" version="1">MSHAQSARIGRMHLSNLPPEIWSLVAEQIHSPQTFIQLIQVCRTFHSIFVPFLHRSHSLLLSRKPAHDWLSWPIPAYLKHAPQGVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1Q0</accession>
    <name>A0A132B1Q0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_726623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060660.1">
        <property type="nucleotide sequence ID" value="XM_018219066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1Q0"/>
    <dbReference type="STRING" id="149040.A0A132B1Q0"/>
    <dbReference type="GeneID" id="28828792"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726623"/>
    <dbReference type="InParanoid" id="A0A132B1Q0"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="364"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ06305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="471" mass="52894" checksum="6193C8E7C472E234" modified="2016-05-11" version="1">MAPITKMSESPAPFRDNLYDASPPPSSRRNTNMTQPSMSPSPGASVSSDKENRSSRPAVDKGKARAPMGPPGVPSMRDGNTRKRAAEQDQAGDRSRRRRTVEVDEDESELDYDPDQDREERRQLRKGLRNLTKTLNENRAEFLAPKSTGLRDTILKANELSHQVKQTSDATIDSRLLVTAADFSLKKTVALCSGDTAQGIDLDDFLMKVKQYMRKGAPEDRAPSNTQRHRRRGQDDDDEDDGDSWNWGYFGRHACVKHISRPSVPGFLLGPLSVEKRVRKPIVRQERLKHSAIKEVRPEVLQAGDIEKNENANLTTLCTQILGQLRQVQAKAIKSVTDRQDDNMTDSQAEELMDKYGVSTDGGIALFKFVINPFSFGQTIENMFYVSFLIRDGKVGIETDNRGLPYLEIKGGRQDEAGGTRDHKPKHQAVLALDMKQWKEMIDVFEITAPMIKHREEEEPSDVSARGWFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2K0</accession>
    <name>A0A132B2K0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_678495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
        <property type="protein sequence ID" value="KUJ06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060983.1">
        <property type="nucleotide sequence ID" value="XM_018213748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2K0"/>
    <dbReference type="GeneID" id="28823474"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678495"/>
    <dbReference type="InParanoid" id="A0A132B2K0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="286" mass="31251" checksum="54559E42E628068A" modified="2016-05-11" version="1">MENLPVDYFVTSQAFTKQTYRDVYPAIDPSSPLNKQDGKVIVITGASKGLGRLGIVLVARTAESLQSVAKEINAINPNIEVLPVPTDLTNPDSIAAMWEKVKTKFDHADVLVNNAGTLTDATSVKDADSGKWWYDFEVNGRGTFLITQGFLKLLGDKKGTVINLTTGAAHTVFPNLSAYSISKLTSLQLIAYISAENPNVNAVSVHPGILPTDMTIEPFKRFALDTPELVGGVVVWLASEEAEFLRGRYISANWSVEELVTRKEEILKENKLTMALVGKFGMDQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3Z2</accession>
    <name>A0A132B3Z2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061467.1">
        <property type="nucleotide sequence ID" value="XM_018216431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3Z2"/>
    <dbReference type="GeneID" id="28826157"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691916"/>
    <dbReference type="InParanoid" id="A0A132B3Z2"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="264" mass="25208" checksum="CE83BF29C2354B2A" modified="2016-05-11" version="1">MSNYDSGNTGSYGDDSYGSSGRQQGGMGGNSGMGGNDTYGSGNTDSYGSSGNQGLGGNDSFGAGQTGQSNLSGGTDSYGAGRAGETGQAGGLGGDNYGSSGRTGQSGFGTSGTDDSYGSTGQSGLGGSDTYGSSGTQGGMGGSDTYGSSGTTGQSGIGGSDTYGSGNTSSGNYGSSTTGGSDTYGSGNTSGGYGDNDTSNTSGNKKGDSTMGKLMEKAGGMMKNEGLQEKGAAKRAAAGNDEYSSGGNTGSYGSGNNNNNDNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4I1</accession>
    <name>A0A132B4I1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_362947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061667.1">
        <property type="nucleotide sequence ID" value="XM_018207009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4I1"/>
    <dbReference type="STRING" id="149040.A0A132B4I1"/>
    <dbReference type="GeneID" id="28816735"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_362947"/>
    <dbReference type="InParanoid" id="A0A132B4I1"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ07312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="506" mass="57393" checksum="FAB45E2880DE4A96" modified="2016-05-11" version="1">MNSGDFGYNEAQTVTSNEQYNIGKKKKLAMRILDRELAIGSPAKQKINRLSMAQGMIPASNADMIIHYNQPVYSGQFSDDGNFFFSVNKDYRVRMYDTSNPYKWRYYKTVDYPGGQWTLTDASLSPDNKYLAYTSIRSQVCLAPTDPNDTGDPYILDLAADTGTARGYRQRFGGSFGIWSIRYSGDGRHLVAGTTGGSVVVYDIESRTPLHRIFGHDEDVNAVCFADKSSPHVLYSGSDDTILKVWDTRSMGDSRAAGAFVGHIEGLTYIDSKGDGRYLISNGKDQSMKLWDLRMVMPTGDFESIRHRRRATRENRFDYRWGEYDEDDWYADPHDNSLVTFRGHRVLRTLIRCHFSPPASTNSRYVYSGSEDGKVFIYNMDATLAGVVDVCEATKASRPRSRHFEMMGWNDDDDDVMNARWRTCVRDASWHPNAPMIVASAWNGYGMSTGTCTVHSWNDGAEDDEAEPGMGLRVDQKLNIDPDFYRDQDRPARRSLRTLRAYVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4I7</accession>
    <name>A0A132B4I7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_405958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
            <dbReference type="EMBL" id="KUJ06577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="149" mass="16492" checksum="0A5E02F917080D67" modified="2016-05-11" version="1">MRMLQTVLWHQWSGSNPICNQILSEIQNSLGHLCDSLLSGSIFISAPTQLCQRGSTRPHLPTDHSIVDLLAPERRSNTYYPCRFRGCEVGGEIVVVDTLPGLVWCTPRSTISSKVEICQPVNSVRVDHHVISRIVRYPAAETAVQTPGS</sequence>
</entry>
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        <name evidence="3" type="ORF">LY89DRAFT_742991</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ07360.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="535" mass="61504" checksum="40DA4DA104C33D19" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4W8</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4Y1</accession>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="738" mass="83400" checksum="02E9A973E290AB59" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5H7</accession>
    <name>A0A132B5H7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_691946</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061499.1">
        <property type="nucleotide sequence ID" value="XM_018216440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5H7"/>
    <dbReference type="GeneID" id="28826166"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691946"/>
    <dbReference type="InParanoid" id="A0A132B5H7"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18921" checksum="54FC59B9455988B0" modified="2016-05-11" version="1">MAITLYEITVPVFIKNLKTLSKCLEKGVAFTKDDGAKISEAGLAESRLIEDMGNLVYQIQRVSDTAKGLAQRIGGVEPVVLEDNEKTFPDLFTRIQKTIEVLEGVKPEHINAQEEAEVVMKTRSGETKWKGKDYALTFAIPNFFFHVVTAYALLRKEGVPVGKADYLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B693</accession>
    <name>A0A132B693_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_725579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062206.1">
        <property type="nucleotide sequence ID" value="XM_018218987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B693"/>
    <dbReference type="STRING" id="149040.A0A132B693"/>
    <dbReference type="GeneID" id="28828713"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_725579"/>
    <dbReference type="InParanoid" id="A0A132B693"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="334"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="942" mass="107387" checksum="7589A3833F76DC01" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6H7</accession>
    <name>A0A132B6H7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_691682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061964.1">
        <property type="nucleotide sequence ID" value="XM_018216384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6H7"/>
    <dbReference type="STRING" id="149040.A0A132B6H7"/>
    <dbReference type="GeneID" id="28826110"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691682"/>
    <dbReference type="InParanoid" id="A0A132B6H7"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="274" mass="30794" checksum="1ADE50B5E9B3A5E9" modified="2016-05-11" version="1">MAAMFKRSFRSNDRVDKVVKLKKSYKDAAKLSKLQKSFDRSPPVGSTLTSPIVTFNVGKEGRLFAAHEDVLSASPFFAAAVRGQFLEAESKRIDLPDEEPEIFSCVLEYLYKGDYYPRLLHNKRRNSWELEDAVSSPNPENTGGRGSVEATTFISSVGEHLLKDTVIYCAAEKYGLEELKRLALRKQGLQSGIEVATILRSARYAYDNTPDSDSRLRAHYLALIIRCRKTFKRSGTMQTEMESGGKLFFDLFVALCNHVDDIVEMGNSKSPKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B8G7</accession>
    <name>A0A132B8G7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_690733</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063050.1">
        <property type="nucleotide sequence ID" value="XM_018216153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B8G7"/>
    <dbReference type="FunCoup" id="A0A132B8G7">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B8G7"/>
    <dbReference type="GeneID" id="28825879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690733"/>
    <dbReference type="InParanoid" id="A0A132B8G7"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    <sequence length="719" mass="79005" checksum="2D6BBA595AD7F07E" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF2">
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    </dbReference>
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        </location>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46936" checksum="EAA32A9ACD9EBE9D" modified="2016-05-11" version="1">MFHDGDVLIVSPTGKQWKLHSLILAQSSPILNKILAAAEPAHLTKKDRDAGKTVFFKLEMVDDSKYRSVDPEGLRYKAFKSVGVNSRALTMPPNINGLGEKATYNEIYDNFFRCMYNLSPEFRQDDDPIARDYIIDCTALLQAADFLDAIPVIRVVVEAHLLRLNQILWHHISEKAENWIHIAAKLHSPLMFRECMIHLVGKYHLENGINQDMLRHSQHGELGAKIWQLIEFKAKELKDKKLKTERHLMEFFPARLAHKDDATSVPGRAIYANDIYFWQALALCRQYFASAFMNGCNYRGADGGLAFYRTVAEGAYLRVDTLDRFHATFEMSSKGKVCLNGSIDLIKNDFKPVVKDLLIDRSQATRGPDTPPFAHFTCTEILDEEFPWYEPPAPTAEYKDDDLDMMGDDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BAM6</accession>
    <name>A0A132BAM6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6 7">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063796.1">
        <property type="nucleotide sequence ID" value="XM_018218897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BAM6"/>
    <dbReference type="GeneID" id="28828623"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724429"/>
    <dbReference type="InParanoid" id="A0A132BAM6"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ09441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="45987" checksum="49F834A5B053FCD2" modified="2016-05-11" version="1">MHVIIVGAGPSGLVLALLLAKANIRTTLLDSASTIDDRPRAAHYAPSAIQVMARAGVLEDIRRDGFIPMNMMWRNVKGEPITGIPKVSQPWSPEAMTVLPLNMLGKVLLEHCEKEERIEIKWNCKVVSVGSDAGKAWAVAEVGREFEKREERYEGDYICGCDGANSQVRRTLFGNEFPGNTWDAQIIATNVYYPFEKFGYDDINFIIDNEDYYMAAKITNDGLWRVSYGEDTKHTLDQVVANQPAKYERMLPGHPKPGDYKLLNVGPYRIHQRCAPSFRVGRILLAADAAHLCNPFGGLGLTGGLVDVGGLAECLEGMEKGVADESILNKYDEIRRQMWHDVINPVSSSNFLRVSATDPETATVKDEFLKMVDEASRDQKVRDELDKAMYAICHDFKQYWKTPGNRVEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBI9</accession>
    <name>A0A132BBI9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_740823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064106.1">
        <property type="nucleotide sequence ID" value="XM_018220641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBI9"/>
    <dbReference type="GeneID" id="28830367"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740823"/>
    <dbReference type="InParanoid" id="A0A132BBI9"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ09751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="492" mass="57041" checksum="19896CA038AFB916" modified="2016-05-11" version="1">METINAPESPGSAVTLIAPTSSSDATFIGMTIELRCMVYKLLLSNPLLSTPEPLDPGSRSQEVEYGLSPALLGVNRQINAEASDWLYGQNKFYMLCKTHRKNTTAPSYEWNPYNGICLSPLTRWLQDTRSMIQATEDNKSAMRKVRYWRVTAAMELDSGQLSSLKLLRNISDFKIRLATQSDMPSSWSSAFKHYPHPHTPWPRMQKFPFGQVLEISNLVKSNEPVERIGDLYDNLLAYARTFEQFQPYKKAMGLTQPDIWHGRELVWYPRNSLSTALRPVLSTKKLEWLQFLDRNLPFQDRNSFHDAHLHPVEAGLLACRHASEFDDMALFKTRRARVIQYLEKHYERVVGASSAITKFMEDQHAGGSLGGSDNEDERCKAGLVLLREYQDAFIRDFLPWIKENIDKYTGWDTFFEQYHCETKDLLRRAQEMIKGKAYCEFLPIFNQVVQLLDKDFIEMQEARQKLFEWDVTDRRCDIDVDLGRFVEGRSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCA1</accession>
    <name>A0A132BCA1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_760799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064353.1">
        <property type="nucleotide sequence ID" value="XM_018221518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCA1"/>
    <dbReference type="GeneID" id="28831244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760799"/>
    <dbReference type="InParanoid" id="A0A132BCA1"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288101" evidence="1">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="218" mass="23213" checksum="8C29B974552956AE" modified="2016-05-11" version="1">MCWIFVALWAAALVGLASGDPVSGASVYHDPETGFTFSQYNVMYSLSETITFRIAVPSPVTANQPYDAVLQVVAPIDVGWAGLAWGGQMTYNPLAVSWSNGNNVVVSSRFATQHAAPPTYSGATYSVFKTGTHVNRTHFQYTAKCTGCTTFTNSAGTPTTINPTGTNRLAFGYSSSRPNNPSSNTSSFPVHDVYNYWSQDFSSGANTAFASLAAKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCD0</accession>
    <name>A0A132BCD0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_740433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064383.1">
        <property type="nucleotide sequence ID" value="XM_018220585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCD0"/>
    <dbReference type="GeneID" id="28830311"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740433"/>
    <dbReference type="InParanoid" id="A0A132BCD0"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288117" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22881" checksum="4C71788E541A502E" modified="2016-05-11" version="1">MKLFHFLSIVPAIFHSTLATSLNDTVEIRATCPSTTRVFDFYPRIFTIKVYTNKFIGDVALVNSGHSKNGYIFHYTPDLATGKAPRFSLTFYNSLRTYENPAGKLPCYLLQSGSGKSAVQFPTCSKPENLGGGTARILSHEWEPRPICLNGQTRYVLVPYFRPNNNAKNVYFDDFTAGEFYPIVYHTASKTPTTMLIIENAPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCJ4</accession>
    <name>A0A132BCJ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_675587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064453.1">
        <property type="nucleotide sequence ID" value="XM_018213522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BCJ4"/>
    <dbReference type="STRING" id="149040.A0A132BCJ4"/>
    <dbReference type="GeneID" id="28823248"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675587"/>
    <dbReference type="InParanoid" id="A0A132BCJ4"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF8">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G13740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="853" mass="95227" checksum="CC0081B1A73C27B9" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDK8</accession>
    <name>A0A132BDK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_675184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064688.1">
        <property type="nucleotide sequence ID" value="XM_018213490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDK8"/>
    <dbReference type="GeneID" id="28823216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_675184"/>
    <dbReference type="InParanoid" id="A0A132BDK8"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="57"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="160"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ10333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="385" mass="43593" checksum="66DB813D5C5DEF57" modified="2016-05-11" version="1">MANILDLAREVQAAAEDFSSGKTRDNLKLLRAIRNLNRIAESPVDRLRRVSYQPVQCAVVRLAVEMGLPHALVEGKTMTAAELAQKSGADHLLTVRVMRVLVAMDICDEIGEEHYESNPTTEALATPTWSGGMRYLFDTIVPTFDKLVAYYNEAGFESDKLLFEYALGQDLWSFLRTHPSLHKDFLDYMKGRKDGQPRWLDYFPVSTQVGDLDVSKHSVTLVDIGGNLGHDLKLFQERCPEIPGRLILMDLPETIAGNSDPLEGIEKIEYDFFTPQPIHDAKFYMFRAICHDWSDENCQKFLGNTVKAMKKGYSRLLINDQVLPNTGAELHPTMLDFTMMAYFNAMERTERQWRTLLDSVGLEIVKIWSFDGGGSEAVIEAMLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEM3</accession>
    <name>A0A132BEM3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_700892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064814.1">
        <property type="nucleotide sequence ID" value="XM_018217153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEM3"/>
    <dbReference type="GeneID" id="28826879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_700892"/>
    <dbReference type="InParanoid" id="A0A132BEM3"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="490" mass="54626" checksum="ABCCD17D2B871ACC" modified="2016-05-11" version="1">MANINLKDIEASKETVAASSEGSVGPAVSHYGQEATHRLLRKLDWRLLPFLCLIYMLCFLDRTNIGNARLDNMEVDLHMGGLDYNVALSIFFPFYVMSEIPSNLMLKRASPRYWFLLIMVTWGIIMTCQGLVKNYAGLLACRVFLGLSEGGLFPGVTFYITMWYPRHETGLRMAIFFSAATVAGAFGGFLARAIALLDGKGGLGAWSWIFIIEGLLTFLVALFCPLAISDYPDKAKFLTEEERVEVKRRLTADTSFSDDFDWRYVKQALTDWKIYANMVLTIGLFTAVYSISLFLPTILKNLGYSSNKSQLMTVPVYMVAFVCTIIGSYVADKSRQRGVFLLGFEVCAIVGFIMLAASSKPNVQYAGTFFAAAGIYPNVPLIGAWNSNNLAGSTKRAVGIGMQVAFGNLGGAISGFIYLSKDEPRFIRGHSILIALISTSLVMTLFMTWWFRRENCRRSRLMMLGNFTPEMLKAQEEELGDKSVTFLYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRL6</accession>
    <name>A0A194WRL6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">LY89DRAFT_626113</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064995.1">
        <property type="nucleotide sequence ID" value="XM_018211095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRL6"/>
    <dbReference type="STRING" id="149040.A0A194WRL6"/>
    <dbReference type="GeneID" id="28820821"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626113"/>
    <dbReference type="InParanoid" id="A0A194WRL6"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="88"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KUJ10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="528" mass="58223" checksum="8A479DF200C2F85F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSV2</accession>
    <name>A0A194WSV2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_739246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065386.1">
        <property type="nucleotide sequence ID" value="XM_018220447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSV2"/>
    <dbReference type="STRING" id="149040.A0A194WSV2"/>
    <dbReference type="GeneID" id="28830173"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739246"/>
    <dbReference type="InParanoid" id="A0A194WSV2"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="345" mass="37528" checksum="D4F368D4FE601D2F" modified="2016-10-05" version="1">MAITKVLLTGASGYIGGAVLAQILKSNHDDVRISALVRSSEHADIIRNLGVESILFKGLDQLDLIKASASEHDLVISCASAMDLPSCLALVEGLAQRRASTGTDVHYIHTSGTLNFGDHPITGKSFLGIRTDKDDIFSWEKETQDDWLLRKVDIGITEAGLRFGVKTYIVNPPIIYGIGNGPIHKQSLQIPALINLSLGFKQAVVLGDGHGIWTIIHISDAARLYDVILQKFLQKQPIDSGRKGYYFVEAGETTWKIISQAIARAGHSQGLFASAELKQLSPETFVESLGIPFLNAGMVEVIWGSNSRIKGIKSRELGWRPEVPIGIFADSIVEDFNIISQNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT52</accession>
    <name>A0A194WT52_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065490.1">
        <property type="nucleotide sequence ID" value="XM_018218778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT52"/>
    <dbReference type="GeneID" id="28828504"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722988"/>
    <dbReference type="InParanoid" id="A0A194WT52"/>
    <dbReference type="OrthoDB" id="10405327at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23909" checksum="B9760B3DAAECC7B3" modified="2016-10-05" version="1">MAGQYSQQRNPGVRHSNPKPQPKKKAPRVPGESRFRNEDLSHNFIGKAYENMPARMYRHNLTATETYKTSGVWWRTARQLVRPETHPEEIVVKKHVSKSLALGAAPTKKSKGRCGRSFRQDNRTSERAMNASPCTKASGEHVSDEDRRQAQDTRLRPEDNLTPCKSTSAQTCEQQTSVQEDNDWVDIESENEQKSPNTDQSATNEDGFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTB8</accession>
    <name>A0A194WTB8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_759013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065556.1">
        <property type="nucleotide sequence ID" value="XM_018221451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTB8"/>
    <dbReference type="GeneID" id="28831177"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_759013"/>
    <dbReference type="InParanoid" id="A0A194WTB8"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="441" mass="50645" checksum="F1CDAD2E63933D34" modified="2016-10-05" version="1">MKRSPCPTILVIGPSLVSASTFATNCTIPSLTTTIVTAPNSRGTLQILWSSLFTIFICIWTVQHLNVPGQRDGRDKNWRGDLKWAWKRFWTKFKWMLFSLIFPEFLLAKAVADWMAAKNTLKIERAYEDPLEWTLAHAFYINMGGFVTRSALRRNDLQGSKLLHLDITHVEIFRLLSYIKKLPITKEEVEDKSKADSLVKASAIAQVAWMVIQVAARTIEGLPVTQMEITACSFAACCFITYMFWWNKPKNINEATDLGLNWVEISERRTSSIVSMRILQIMLMYEWSSMAHINMSLYDQPPRNDSLLRTQRDEHRTQFYFSQGLMFGGIVLGATQCAAWKLDFPTKVDRDIWRFASIASASVVILFYALSLQEINSRWPDAVDRNLSKRKSPIFVVLSLLCGLIYTVCRMFILFESVYSLFHLSPEAFKTTWSTNLPHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTQ0</accession>
    <name>A0A194WTQ0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_723149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065690.1">
        <property type="nucleotide sequence ID" value="XM_018218793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTQ0"/>
    <dbReference type="STRING" id="149040.A0A194WTQ0"/>
    <dbReference type="GeneID" id="28828519"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723149"/>
    <dbReference type="InParanoid" id="A0A194WTQ0"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008443849" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="40"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="650" mass="71259" checksum="B2C6ADEA7A3B7B5C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTT4</accession>
    <name>A0A194WTT4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">O-acetylhomoserine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">LY89DRAFT_688984</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:27822"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-acetyl-L-homoserine + methanethiol = L-methionine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10048"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.5.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from O-acetyl-L-homoserine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="12"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065377.1">
        <property type="nucleotide sequence ID" value="XM_018215823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WTT4"/>
    <dbReference type="FunCoup" id="A0A194WTT4">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WTT4"/>
    <dbReference type="GeneID" id="28825549"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688984"/>
    <dbReference type="InParanoid" id="A0A194WTT4"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000083">
        <property type="entry name" value="O-acetylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KUJ11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="457" mass="49068" checksum="C86D5715BBB71EEC" modified="2016-10-05" version="1">MAPVESEHFETLQLHAGQEPDPATNARAVPIYATTSYTFNDSAHGARLFGLKEFGNIYSRIMNPTVDVFEKRIAALEGGVAAVAASSGQAAQFMAIAAVAHAGDNIVSTTNLYGGTYNQLKVFLPRLGIHTKFVNGDKAEDFAKAIDENTKAVYIESIGNPKYNIPDFEAIAKLAHEHGVPVIVDNTFGAGGYFVQPIKYGADIVVHSATKWIGGHGTTIGGIVVDSGKFNWGANAKRFPEMVEPSPGYHGLKFWETFGPITFAIRVRVEILRDLGSALNPFAAFQLIQGIETLSLRAERHAFNSLALARWLESSPHVSWVSYPGLESHPSHELAKRYLKRGFGGVLSFGVKGGGAAGSQVVDGFKLISNLANVGDSKTLAIHPWSTTHEQLSEEERLASGVTEDLIRISVGTEHIDDIIADFQQSFEASAAAKTTGGAEENAEKTGNVEADAKMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WU27</accession>
    <name>A0A194WU27_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_239290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065539.1">
        <property type="nucleotide sequence ID" value="XM_018206092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WU27"/>
    <dbReference type="GeneID" id="28815818"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_239290"/>
    <dbReference type="InParanoid" id="A0A194WU27"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267449" evidence="2">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="69"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="400" mass="45017" checksum="03D7E445393218D6" modified="2016-10-05" version="1">MKTSFVLYCAVALSGSIQAVLHRFPIHEHYVPTPSFAQRFKREQVPFSYQDFNDDTHKIPFKDVAIVLYGIDATLGTPPQPFLMSIDIDWDVLFVPSIACASQFCNSRKLSRFDSSISSSFVQGQQQLTIEYASMMSHGAISNETLSFGGLQVERQPFLEATDIWADGYFHWYRGYSGVIGFQPRFDTEAVVPFSSPWQTIVESGTLDRNIFSIRLPNGPHDFLQPRTNGELVIGGVDTQYSDHNFTILPLTPTTPDSWSVEARSVIWGDGTSLRQDFDHCVATFSISIPAIRLPGAWSHRLYELIGAREHDGFFMTFPCQNREFLPNLTIVLGGNEMILTPYEYSLESVGQPGSGLSCMVGFDQSPDNTIQLGWPFLENFISVFDQDLREVRIAKSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUH1</accession>
    <name>A0A194WUH1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_722728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065963.1">
        <property type="nucleotide sequence ID" value="XM_018218752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUH1"/>
    <dbReference type="GeneID" id="28828478"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_722728"/>
    <dbReference type="InParanoid" id="A0A194WUH1"/>
    <dbReference type="OrthoDB" id="4497263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="22765" checksum="1BC8B8396638573F" modified="2016-10-05" version="1">MSASATTHPPETSFGTVTSWLPLTTPFVSPDGCSSALWARWGFIQSESYNALAFDPSYDGISFDGRLSCLPPEAKLWWERDSSVKSGVSTEYSIGLIVCPQDYATVGTSIVGAGSTWVACCPSSSSGAKIEIGVGIGGAVICLLAFLLLPIRHQLKERKAGTQLEFSREGRPEWKVELLGAGKILAHHELPAMHETDMDITSIPQWHELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUS6</accession>
    <name>A0A194WUS6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_674019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018213405.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28823131"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674019"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="885" mass="99281" checksum="C0DC438B2753BDBD" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVN2</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_674292"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ11729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="142" mass="16228" checksum="86D197D79147FBD1" modified="2016-10-05" version="1">MGSATPAGERYDRQMIYSAAQQGKEDMAWTKTAVTDRTGWRDAREFNGTRKYREFGLHDARWAGRVSSRDTAGEDVYSRRLVWSSLGPYSRMDYFGWWIVDGGSKWKDIAGPIALVWSFNAAAVPYRVLQQYSTTMSTTVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWI4</accession>
    <name>A0A194WWI4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_688424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018215701.1"/>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_688424"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="134" mass="14536" checksum="7A68FAF546F8F732" modified="2016-10-05" version="1">MMGGTKLLVCGQAVLLPQAEKPSWEVGTCVSPQDKLSCLSVSHTAPPSSSHPSNIKRHHQPPLSTLPIPRASQINPQHHSHPPPSPSQARKPAMAFPFPFPLHNPSHQESKIPESRIYTEKACSTGPVHPVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWK9</accession>
    <name>A0A194WWK9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">LY89DRAFT_653531</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066322.1">
        <property type="nucleotide sequence ID" value="XM_018212257.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWK9"/>
    <dbReference type="GeneID" id="28821983"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_653531"/>
    <dbReference type="InParanoid" id="A0A194WWK9"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <end position="869"/>
        </location>
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        <location>
            <begin position="949"/>
            <end position="1126"/>
        </location>
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        </location>
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        </location>
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            <end position="350"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="10"/>
        </location>
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            <end position="347"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1478" mass="165729" checksum="6C94CB9B57410367" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWL0</accession>
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    </gene>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="26"/>
            <end position="117"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="22620" checksum="22B624CAA22823D6" modified="2016-10-05" version="1">MRLLQYNNDGELSLTKDFIGDEIPKYTVLSHTWGADTEEVTYRDLINSTGKSKVGYEKIRFCGGQARRDDLHNFWVDTCCINKSSDRELSEAINSMFRWYRKAAKCYVYLTDVSTNDQIDLSLQPWEAAFGNSRWFTRGWTLQELIAPLSVEFFYSNGNRLGDKKSLEGQLHKITGIPVSALQSSPLSEFSFDERIS</sequence>
</entry>
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            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="352" mass="38365" checksum="A87CABB614E1D0C5" modified="2016-10-05" version="1">MEIEHDFPAPKAVMPSFERAEQYFSHEESQSLLWTTEDSFFEGAESVEGMNLDFLVSDFSPPSWAVSKSNENNSSTPLTLEMTMEKTGCSKSQLISPPESLPSTALSQSQGSSAEQSAEQPQKAVCLNIDNLETASASAPSKEVTRNEKSYQHLPLLLETTLRFYFKAPSATQAPISDALRLAKDGLQAIQCCLREFYLSSRAQASSSGLSSHDPSPPEPDSESSSILACIILMEKVLFCYDSLLKRRSGPGDVSSPYAPSPAPSSTSTSNPTASSSSGHHCMQPIFIGDFEVEDKASWKMILDAVVAAQKQEARSTISKLEDWASDLAGKGKNEGRLAISFLEQLKRKFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYJ0</accession>
    <name>A0A194WYJ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase-like protein component Gpi16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_785975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194WYJ0">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WYJ0"/>
    <dbReference type="GeneID" id="28832668"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785975"/>
    <dbReference type="InParanoid" id="A0A194WYJ0"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267670" evidence="2">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="581" mass="65423" checksum="BF11E043679FE63C" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYR4</accession>
    <name>A0A194WYR4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067456.1">
        <property type="nucleotide sequence ID" value="XM_018213345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYR4"/>
    <dbReference type="GeneID" id="28823071"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673198"/>
    <dbReference type="InParanoid" id="A0A194WYR4"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="762" mass="85638" checksum="B23D4F29669500DA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYS0</accession>
    <name>A0A194WYS0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_738003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067466.1">
        <property type="nucleotide sequence ID" value="XM_018220320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYS0"/>
    <dbReference type="GeneID" id="28830046"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_738003"/>
    <dbReference type="InParanoid" id="A0A194WYS0"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="292" mass="32956" checksum="6C53C909BEA0C93B" modified="2016-10-05" version="1">MANGNNGAEGHEKVRVLLLFWEADDMNVKAELEPLKFFFAEECHYSVVEFMIPSIDAEGRLSDQIRETENFCMTEKAALIVVYCGHGSVDESKQYRISAFGRGSRHNGGNPWNSSPWLNWNSVQNWLQTINTDVLILIDSCYAAAAAAFDTGLKSLQRTEMIVACGYEAVTHSSMQHMSKKMTKYLRKSHPILGPMPSFTEVLVECLSSTLKTGDSFSVTRLHRDLIRHIVEQNFAQRRFGEATRTPIYIKIDEDNTRSSIKFNRGSVVLGPPVKPLKTLKDFEKPLESEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYU9</accession>
    <name>A0A194WYU9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_687981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067475.1">
        <property type="nucleotide sequence ID" value="XM_018215616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYU9"/>
    <dbReference type="STRING" id="149040.A0A194WYU9"/>
    <dbReference type="GeneID" id="28825342"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687981"/>
    <dbReference type="InParanoid" id="A0A194WYU9"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="178" mass="19875" checksum="B1C8565171A7AFAF" modified="2016-10-05" version="1">MDTINALLHPHHVSLGKNYTSIHMLHQHIDDPYYSLDHHASHKGVSVPRFNIREGQKAFYLEGELPGLTHLSDVVCEFIGNQTMIIRGAIKSFVFAGEGEQTQAAALKDSKAPVETSLTWRLNERHIGKFERSFTFSSRVKPTEIHTSLDSGVLSIAVPKDKEADAKEAAKSEIENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZ31</accession>
    <name>A0A194WZ31_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_687418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067570.1">
        <property type="nucleotide sequence ID" value="XM_018215495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZ31"/>
    <dbReference type="FunCoup" id="A0A194WZ31">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WZ31"/>
    <dbReference type="GeneID" id="28825221"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687418"/>
    <dbReference type="InParanoid" id="A0A194WZ31"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="227" mass="26390" checksum="9DFB6A34A1E56ACB" modified="2016-10-05" version="1">MPLHPPSHPSLTHVRTFTCTAQNLAKSTKQRLKYEHTAVPPYPYGPSQIYKQSNFGLYGTQKIRFGNMVSEKNEIKTRRYWRPNVQFKRLWSEALQNYIKLRITTRVLRTVDKVGGLDEYLLGEKAARIKELGMGGWKLRWRIMQTNAVKERFRLQREAYGLPPKVDAPTRWNGQKATKLQVAEEIREFDADIAKGQELEIGEDMEEQVVEPGSMQEEPMRSEKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZF1</accession>
    <name>A0A194WZF1_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_673183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067439.1">
        <property type="nucleotide sequence ID" value="XM_018213342.1"/>
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    <dbReference type="STRING" id="149040.A0A194WZF1"/>
    <dbReference type="GeneID" id="28823068"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_673183"/>
    <dbReference type="InParanoid" id="A0A194WZF1"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="297"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="818"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="972" mass="106749" checksum="FD7EF24BA050285D" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WZR8</accession>
    <name>A0A194WZR8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_591777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067795.1">
        <property type="nucleotide sequence ID" value="XM_018209667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WZR8"/>
    <dbReference type="FunCoup" id="A0A194WZR8">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="28819393"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591777"/>
    <dbReference type="InParanoid" id="A0A194WZR8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="141"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ13440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="637" mass="69547" checksum="D22DF5FA54FCC57E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1N8</accession>
    <name>A0A194X1N8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_687355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068463.1">
        <property type="nucleotide sequence ID" value="XM_018215479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1N8"/>
    <dbReference type="GeneID" id="28825205"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687355"/>
    <dbReference type="InParanoid" id="A0A194X1N8"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="306" mass="34869" checksum="3214B0E17E4647C6" modified="2016-10-05" version="1">MLVKARPVNESIQEINDNSWVIGDRILLSRRRSPLSGFTWGDGRGSFYVISEAPYPLPPSRPLSATTPFEKVYDAGGVSAVWSIGDAFCKVKILHPDATREHVTLDYLHSKCPLSFAIPEVHYHAEYDGRHYIVLSRLPGHTLTNAWQNMDEEMKQYYVSRVANICKELAVWQADYISGVDGRHLSETYLTRLGQSEDCSPENLLTNCKGLGMDCSIFVLYHYDLGPGNIIVNLADGSMGIIDWETAGFVPREWIRTKFRVSGGMDLPGSDQELRVDWRRRVQRRLGEEGFPDIADRWMVWWRNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X278</accession>
    <name>A0A194X278_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_687358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068464.1">
        <property type="nucleotide sequence ID" value="XM_018215480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X278"/>
    <dbReference type="GeneID" id="28825206"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687358"/>
    <dbReference type="InParanoid" id="A0A194X278"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="209" mass="21561" checksum="A680C51FF248F9D6" modified="2016-10-05" version="1">MASPDKTSTAQGDLCTNTRDSSLGASSLNLNNLNHNRTVNSDRETEPPAYQERPPHYEMSHSDPNPNNPAGDKASTPRSVAVTAGAGDNVSTPHLVAATAVAGDNASTPHLVAATVAAGGNASTPHGNALSGHEAAATSAGTAPRSAGPYGHTYQPPVRGPPPSRLRHCWICSREPTAALILIGGVLTFVYKMYYLYVVGHGDGAEQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3B5</accession>
    <name>A0A194X3B5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_686803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068672.1">
        <property type="nucleotide sequence ID" value="XM_018215364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3B5"/>
    <dbReference type="GeneID" id="28825090"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686803"/>
    <dbReference type="InParanoid" id="A0A194X3B5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="55" mass="6288" checksum="F922406DB95999B2" modified="2016-10-05" version="1">MDSKFEHPEPDPSADGKVRATSKRPMPPLHLPRIQSEKYNNNAEEESRLLNLRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3R0</accession>
    <name>A0A194X3R0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_590123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068807.1">
        <property type="nucleotide sequence ID" value="XM_018209575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3R0"/>
    <dbReference type="GeneID" id="28819301"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_590123"/>
    <dbReference type="InParanoid" id="A0A194X3R0"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S53" evidence="2">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="246" mass="25501" checksum="1C9D0DB0E83C7362" modified="2016-10-05" version="1" fragment="single">ICQCCLQMGARGVTVLSASGDDGVGPQGLCFTNDGKNTSAFLPEFPASCPYVTVVGGTKNVNPEIVAASTDGSFASGGGFSNYFGRPTYQDDVVPAYVKSMGTKFQTLYNSSGRAYPDIAAQAFQFLIVWNGTIRAVSGTSAATPTAASVIALVNDALIAAGKPVLGFMNPWLYSVGFKAFTDVRSGSALGCNTTGFPAQTGWDAVTGFGTPVSFVVDNTTDVWISLMYPQNFPAIRAAAMNGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3T0</accession>
    <name>A0A194X3T0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_686949</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068837.1">
        <property type="nucleotide sequence ID" value="XM_018215399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3T0"/>
    <dbReference type="STRING" id="149040.A0A194X3T0"/>
    <dbReference type="GeneID" id="28825125"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686949"/>
    <dbReference type="InParanoid" id="A0A194X3T0"/>
    <dbReference type="OrthoDB" id="3559948at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008267810" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="187" mass="17524" checksum="1144561816D2B65F" modified="2016-10-05" version="1">MKITISAMLIALAGLVSSQNFGAEPSCAIPCLTSAFSVAGCALTDQACQCGTGQAAIQTAVTPCLLSACDAADVNSAASVGFALCSAFSMTAGANATTTPSSSSHSSTSIIMSTPSATTSTVTAVTTSVGSGVTSTATTTSAKSSGTGSGTSSSASAVSSAGAQKGQMMAAGLGGVVGVLGAVVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3X7</accession>
    <name>A0A194X3X7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_698473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018216983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3X7"/>
    <dbReference type="GeneID" id="28826709"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698473"/>
    <dbReference type="InParanoid" id="A0A194X3X7"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ14898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="32183" checksum="12819B9D46BF29AA" modified="2016-10-05" version="1">MIAYRAPSLLQPHRFREAIKDAHDGKIRPLVAYFCGLSCPPIAKVIAQMGYDMVAVDWEHSSCNVETMTQMVHDIQFMSEGRSHALVRVPGHDHAAIGYALDAGASIMVPQVNTVEDAKHICSAAKFGAIRNGTRSAPPARFLPGISDIGSDPSLGWHENANNNAAVMIQIETLEAIHNLDDILTECGDQIDAVWLGTLDARVSMGLPANGGMGGTEQEWLDAVAVYESTMAKHNKPATGFSMGTPEQMERTARGKCLVVVGAEFYAVMFNCMEQLGKYRAFLPQQNYKGVYKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4F9</accession>
    <name>A0A194X4F9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_619807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069067.1">
        <property type="nucleotide sequence ID" value="XM_018210893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4F9"/>
    <dbReference type="GeneID" id="28820619"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_619807"/>
    <dbReference type="InParanoid" id="A0A194X4F9"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="253" mass="28825" checksum="5CA0FC287B4F6004" modified="2016-10-05" version="1" fragment="single">MDETESGNYQLFRECLSTPLIEKSSTKPESKTKKSRGSGRRKTAIKPVVAQEPDDAEELADFIDYIATEIFTNLPPDLRTLTYSTWLNTPTLQSTYTDPPSPALLHKIINPLPASITDTLTTYSLLNPTLDQDTTSFLTPILSTYISSLLTPPLAPHLARPLATECEICDRSWIPLTYHHLIPRGVHAKVLKRGWHTEDQLENVAWLCRACHSFVHRVASLEELAREWFTVERLLERDDVRAFAKWVGKVRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4G5</accession>
    <name>A0A194X4G5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_120136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069072.1">
        <property type="nucleotide sequence ID" value="XM_018205139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X4G5"/>
    <dbReference type="GeneID" id="28814865"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_120136"/>
    <dbReference type="InParanoid" id="A0A194X4G5"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="334" mass="36315" checksum="6FF41F902507060B" modified="2016-10-05" version="1">MSALPHTPLSIEPEFLAIPSKPQSPICFTFFPAINSQTSTSSVQHLIVFINGLGLPAASWLPSISLLRSQPSCPTIITYDRFGQGLTTSRDPLDGTSGKELGHDFLDVATDLHEIILTISTKKLGLNASDVAHGGKLHLLLVGASIGAPIARLYVQHHPGTVAGMILLDSNIANVNYSDFLPDPSSPDFDPKKMLGEDCTLEQYREARAKLVAMFDLNVKNPEMLDRTTSPKLLPHADKPALKGVGGVGLRLMIVGHDPETFAEMSFQMMGTPRTLSRITNAYWAEYNQGLTKITDEKLSGPVIIANGCGHFIQKDDPIFVADTIMNMIKALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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            <strain evidence="5 6">CBS 120377</strain>
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        </source>
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            <dbReference type="Pfam" id="PF24883"/>
        </source>
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            <dbReference type="EMBL" id="KUJ15039.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1530" mass="172730" checksum="AE09BC7BD35A3989" modified="2016-10-05" version="1"> </sequence>
</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="324" mass="35202" checksum="944D94A89CA2403E" modified="2016-10-05" version="1">MGLVVAVPLPDDSDSHSPVASRQKSETYQSSQTTRYSTILQKASRGKGREGKAVQLAVSWRAPSPLHRALAASDKPNTSLRNTHIPSIAPQDPSRRKQIIDSIAESSSATRVQPAYEAVPAPRRSFIKSLATGAESGHGHYINLQPALLDPRRALAGWLAGWSSPSTLGSPRVYNLKFVQVIYVLSRWIVWDYPELSHSESIMAYGRIASQNLPVPVIEQLLGPHINRWTPGHQIRCAIGTSTRRPGLKRLLLLARPAVARPLTSPSPPGPAERLLALHNAAAAPFVRHITLWKTTATVSSLPGRLIGRASMSLTRSCVGGYLD</sequence>
</entry>
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    <accession>A0A194X783</accession>
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        </recommendedName>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="28833241"/>
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    <dbReference type="InParanoid" id="A0A194X783"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ15677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="245" mass="26976" checksum="F5A723EF49DEF415" modified="2016-10-05" version="1">MSRVTPPVTKLTHAVRRISTSSKAARPSTLLESSRSSRYLPRNTKALKEECKKRQLNSTGNKAELVDRLAAHDMLSTHRDYHSMSSGHRPTTPSVPVYHTIPLMQGFQTSAPKQAINDMSTIDFFFFPEIPADPPLNPFAKLRVPLLPDNYNPDRSPGTPHAIETIDEALPRPEIHIVASHPEDVMPATISEVVGNDGLDIDLASLTKNFSSTAIKELKEKSLVGELWSGIVDDVLGPKSRKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7G2</accession>
    <name>A0A194X7G2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_75073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070468.1">
        <property type="nucleotide sequence ID" value="XM_018221210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7G2"/>
    <dbReference type="STRING" id="149040.A0A194X7G2"/>
    <dbReference type="GeneID" id="28830936"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_75073"/>
    <dbReference type="InParanoid" id="A0A194X7G2"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33992" checksum="0F262EBC5EB68951" modified="2016-10-05" version="1">MDKREAITASNLGPVVSLLAWIMVASVLIAVGIKFTLSSVILRRWITEDIALALATVFSIGFSVSISLAVPNGIGRHQTTLSSDQLKSLQKAVYSASILLVLVSSCAQASILIFLYEITPRLSHQRLIYSVAGFTALFFIPSFFVAVFPCRPPDVWEVLGSQCIDQSFFWRTFAGVNLVIESALILLPAFMVWPMTMDRRRKSIVITGFAARLAVMGAFAAQFYEAQSLETQLLDKTFDTWRYHVTTVFVQGLSIITVCIPYIRNLLLGMESGMIQTGHFRLPDRHGLEPEIPLRLNSLNNTGAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7J4</accession>
    <name>A0A194X7J4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_685717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070132.1">
        <property type="nucleotide sequence ID" value="XM_018215138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7J4"/>
    <dbReference type="FunCoup" id="A0A194X7J4">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X7J4"/>
    <dbReference type="GeneID" id="28824864"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_685717"/>
    <dbReference type="InParanoid" id="A0A194X7J4"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="206" mass="23924" checksum="38F92978C1AA4B36" modified="2016-10-05" version="1">MDTRLIRRPVLDLLSGRSQCLFSLNAASRRNESSYRRTKQRLNIKPDSSFLNSKHSPNQDHIIFNPPSSAPSVLHTPLKFLPKEDKRRQLLASTATRHQATDSILPPPVHVKRSVPHHHLSEADVREIQRLKREEPDNWTCAKLARKFNCSTFFVSICLTQCGVDNTQKKKEMQEKLEAIQARWGPRRRKAREERAKRYELANRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7S8</accession>
    <name>A0A194X7S8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_782515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070573.1">
        <property type="nucleotide sequence ID" value="XM_018222586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7S8"/>
    <dbReference type="GeneID" id="28832312"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782515"/>
    <dbReference type="InParanoid" id="A0A194X7S8"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="349" mass="37189" checksum="0718E9EF066F1571" modified="2016-10-05" version="1">MSISIPRTQKQWTVEGLNGLESLKLNMEAPVPEPSDYEVLVKFHAASLNYRDLMITEGVYPFAQRDGIVPASDGAGEVVAIGPKVTRFEIGAKVVTLFNQGHFGGSLDTKTAKTGIGGMLDGTLRQYGTFLESGLVPMPPSLTYLEASTLSCAAVTAWNALYGLKPLLPGDVVLTQGTGGVSIFGLQFAKAAGATVIATTSSPEKASILKSLGADHVLNYKETENWGEVAKRLTPGGEGVSHVLEVGGPVTMAQSLEAVKIDGVITLIGFLGGVGQPQPGFETALRKLCTVRGVLVGSRGQFEEMNRAIEGNGIRPVVDGRVFALEDVREAYRYLWERRHFGKVVVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X978</accession>
    <name>A0A194X978_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_697540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">CBS 120377</strain>
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</entry>
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        <source>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Labutti K."/>
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            <end position="64"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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            <end position="215"/>
        </location>
    </feature>
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        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="447"/>
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            <begin position="39"/>
            <end position="453"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ16895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="487" mass="54661" checksum="C1CD3D783117E6CA" modified="2016-10-05" version="1">MFNHSDEDIAAQYADRLDGEDAYTTSEEKRLRWKLDLRLIPILWFNVTLGAMDKVTTSTAALYGMKASTGLTGNRYSWVGSAFYFGYLVWCFPSAGLLQKLPIAKTMASAQLLWGLVLIGTGFAKNFETLIALRVLLGVLEAPIVPGNYLIVGMWYSRREQPIRTGLMYTGLSVCFTGPIGYGIGFIAGADKWRYFFWITGAMTCVWAIIVGIFLPDNPVKAKFISERQKAIAIDRVRADQTGIENKTFKREQMIETFLDPKTWLMFLFNIWISIPNGGLTNFAPLIINGLGYTAQRSTLLTMPTGIIQTVSSYMCNGGVFLCAKYLSNYQLRGAWVMFSCIIGMIAAVFLYTLPLYNLHGRLAALYVSYFYLGGYIVALGMNTANTAGHTKKVTTNALIFIAYCVSNIIAPQFFLARQAPLYVLGMGAILASYVLSMITMAIYMAYCAWENRRRDKLDSAAGQKIHRDTDFKDLTDKQNIHFRYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA61</accession>
    <name>A0A194XA61_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_718744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071411.1">
        <property type="nucleotide sequence ID" value="XM_018218440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA61"/>
    <dbReference type="GeneID" id="28828166"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718744"/>
    <dbReference type="InParanoid" id="A0A194XA61"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="298" mass="33395" checksum="1B02FF152D0F024D" modified="2016-10-05" version="1">MSGYTKLAKFMTQKHHPILRKFQHLATRDLLYLQAELCELDFKHDTIAKKDALETDERQYYGRDWQYLESSNQRGFGGEQWAVALATRAKLREYYAALSQYSQIASIPEPSPSERTILHDWIGSPAMGGGCGFLGRDLGGYEQLSVYEDLHQSDLAILSDAHGEDDLFTRFVTGPLLTLYHWILKRRRNPLAIDPENPPVGDNRSNLHHYDDRRIEMVTNILGTVFSSFAPLLSIVVLSFVSNAKARLGLVCAFTILFTCCLAVATKARRVEIFAASAAFASVQVVFIGSSNSNSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBA4</accession>
    <name>A0A194XBA4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_615570</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071810.1">
        <property type="nucleotide sequence ID" value="XM_018210730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBA4"/>
    <dbReference type="FunCoup" id="A0A194XBA4">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XBA4"/>
    <dbReference type="GeneID" id="28820456"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615570"/>
    <dbReference type="InParanoid" id="A0A194XBA4"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106407">
        <property type="term" value="F:Glc2Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033919">
        <property type="term" value="F:glucan 1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268094" description="alpha-glucosidase" evidence="14">
        <location>
            <begin position="30"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="16">
        <location>
            <begin position="97"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="400"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="18">
        <location>
            <begin position="736"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="17">
        <location>
            <begin position="843"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ17455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="966" mass="109767" checksum="621F3C311F685C71" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBK9</accession>
    <name>A0A194XBK9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_569766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071507.1">
        <property type="nucleotide sequence ID" value="XM_018208579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBK9"/>
    <dbReference type="STRING" id="149040.A0A194XBK9"/>
    <dbReference type="GeneID" id="28818305"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_569766"/>
    <dbReference type="InParanoid" id="A0A194XBK9"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268107" evidence="2">
        <location>
            <begin position="19"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="395" mass="44022" checksum="5BD33D211892C96A" modified="2016-10-05" version="1" fragment="single">MFRVFFLITAFVVTTANAQNQTSASQPLGKVGWEPGPTRRGTLTLVWSCLATIITCTWSILHLNVPARGDSAWTKRLRKLKWMCVTILFPEFIFAKAVCELKDAVDNTFEMKRHEIELNWYVEFGRACRVWYRIFHLGNPGRGGTMMGNGPQWTFWTPVHSYFANMGGFDDASVSTIDSLITTSGLLARCRGEPSKSNLFPSKADIEDKGKADLLVKLLAICQILWLVLCVIVRRTTRLPVSPLEIAAVAFSTIAILTYITNLWKPKDVDVPIKLSIPNQYGRVSTDRTALSTARHTLIPFFPFLVKPSGIRFPSTPQSHNSLAVWRASRARISNDSIRKEGSMGMISIITAMSAFVFGSLHCVAWSFEFPSRAEILIWRVGGVASATLPCVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBZ3</accession>
    <name>A0A194XBZ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_584027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072039.1">
        <property type="nucleotide sequence ID" value="XM_018209244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBZ3"/>
    <dbReference type="GeneID" id="28818970"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_584027"/>
    <dbReference type="InParanoid" id="A0A194XBZ3"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="236" mass="26963" checksum="7C1CDAFDB81C185E" modified="2016-10-05" version="1">MSFRISEIVSDSEFHELVEVEFISFEHPRNAFRDLFYPILGTGPDARQQAIKEATSRIIHNHRSNPFSHWVKAIDPHSDRLVGAALWIFFESDPYTGKPLPECTWWPQGEGREFTTRCLMHVSKMRLLCCRGTKAVTDEDQSDLNLCFVHPDFRRQGAGSQLLAWGVSKADEQKMVAYVDASGDGKALYEQFGFVASKQVTVNFTKDNPGELWKRLEKISLPHSFWPMSRPKLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCI7</accession>
    <name>A0A194XCI7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_644969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071817.1">
        <property type="nucleotide sequence ID" value="XM_018211853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCI7"/>
    <dbReference type="STRING" id="149040.A0A194XCI7"/>
    <dbReference type="GeneID" id="28821579"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_644969"/>
    <dbReference type="InParanoid" id="A0A194XCI7"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="91"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ17462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="33080" checksum="021B1062CBEF5F30" modified="2016-10-05" version="1">MASSDKPLRIGYVPEHFSTPLYFAQKHFGLEGELIAFPSGTGHMITSLRAGEIDIGIGLTEGWVAGLGKDEVEGDGGYKIVGTYVETPLCWAISTGAKRDINSIADLKNGKIGVSRIGSGSYVMGFVLADQQGWLSSDPSTQPFEFIPLQTFEKLRNAVNDSTADFFMWEHFTSKRYYDNGEIKKVGEIYTPWSSWKIVASTSIKENDARLEEMFEKLDKGVRYFGGNKEEAVKYISTKLDYSEADAREWMKTVKFTSGTKGVDLSVIQKTVDTLKKAGVLKDGGMKPEQMIASQRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCS7</accession>
    <name>A0A194XCS7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_668179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072330.1">
        <property type="nucleotide sequence ID" value="XM_018213028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCS7"/>
    <dbReference type="GeneID" id="28822754"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668179"/>
    <dbReference type="InParanoid" id="A0A194XCS7"/>
    <dbReference type="OrthoDB" id="10349418at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="102" mass="11412" checksum="D9060B697C72F667" modified="2016-10-05" version="1">MSPLRPTIVIHLMRSTKLRTQTGESIDPVAIERAHEFAETYPHLKHIAHLFSSPTDRDKEVAGTAFAPVLSRGIKHQILPILRANTRLQAMLPTNGVKVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDF2</accession>
    <name>A0A194XDF2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_41651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072558.1">
        <property type="nucleotide sequence ID" value="XM_018207374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDF2"/>
    <dbReference type="STRING" id="149040.A0A194XDF2"/>
    <dbReference type="GeneID" id="28817100"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_41651"/>
    <dbReference type="InParanoid" id="A0A194XDF2"/>
    <dbReference type="OrthoDB" id="5278722at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="502" mass="56338" checksum="435E173BA4CE7373" modified="2016-10-05" version="1">MFNIRKRLGASILLTVLSIISICLLLPDSKVRQLQKITLGTTIEYTDLWKWGSEDDVDDDEDNGNGVRLVIFGDSWVDDLIEEGQGEKGNTWPQVLCEEINCTSRLNFAASQLSDAWPASPPTGAMTSNEIHAWAVSQNQLLRGGDYNYSAYPDLASQIQSYISLPAPRTQPQATIFILSFGFWDIYDFAQLNFPAAQNVTDTSIDFLFDQLDVLYAHFATKLYPITEIPQISNSTNATTYSTSEHKFQVIIPRILDPTLLPGWVIQRPIPAKPSSVAEQQKNAIYLTERWNQGVENKMGAWMERTVDISPAPTESVAPPAESTEPETRADVRENATERQSENGKFQQFDGNVPTKEEKHNSNKDDDKPEEEPKEEETQNLPKKDIFYHDSASILLDIILEHQLEDEGLSDALGLGKGESPYESVSIPCMRPMDLEEDIMELVTHWKENNGMLICKEPEDFMWWDAWSLGGKGKKMVGEAVGEVVREGKSLRAKKEGKGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE01</accession>
    <name>A0A194XE01_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_717616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ17977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072332.1">
        <property type="nucleotide sequence ID" value="XM_018218359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE01"/>
    <dbReference type="GeneID" id="28828085"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717616"/>
    <dbReference type="InParanoid" id="A0A194XE01"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="425" mass="46908" checksum="9EE35011A463745A" modified="2016-10-05" version="1">MPRCDYGTRLPSRADPTRALAPAQPGSSSSSSSSSSSDSGNEDWKMSLPASLRGASPFLLFRLILSANAWRLEPHVRQQHGLSFAFLCAESIRLLRDRVENEGGDIGVRDETISAVATLAGIEHERGNTKMLRMHLEGLKRMVNIRGGLNAIRENNPMVANSVFWAFAVALYEAPYPNLDAELPPFFPNEHDLALPSPAVVSIFQDFGPIHEEPPPLDLTESGVNPGIAVIVNSIQHVSQLVPTASAYPTASTSMVILTRMCTLLSHLLSLPRARLYPEIDTNATLAEAALISESVRFATLLHVFTPWRGLPPDGTLAINHILHQLMASLKQLLANATSRNNTVLLWMLTVGGVSAGQTPERAWFVSHLVELTEELNISNWEGMKSHVRRVIWHERLCENSHQKLWEEVMTKRRELDDGMGVNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEA8</accession>
    <name>A0A194XEA8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyl transferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_613413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072834.1">
        <property type="nucleotide sequence ID" value="XM_018210663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEA8"/>
    <dbReference type="GeneID" id="28820389"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613413"/>
    <dbReference type="InParanoid" id="A0A194XEA8"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF4">
        <property type="entry name" value="O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="216"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="381" mass="43110" checksum="99F6B3B78E2AC11A" modified="2016-10-05" version="1">METALEDIKRLAISSDEDARQSIMSALHKLAYSMESPNDTIRRYGHLTLQTAAIKIGIDLGLFVYLAESKSPLFAEQIAQTTGADIQLLNRVLRYLSAIDALDEVSKNSYRANHITQNLAQKVTEAGIRHYFTTVAPQYHALPTFLKRTNYKSPTDELHTAFQDAWKTSLHAFSWFADNPDHLAPFNDFMALRRQPGLSWLSMYPVVQESRGWEVEMPIYVNIGGGIGHQCAQFKEMYPDIPGRVILQDLSHSIANALQTPGVENMEHDFFEPQPIKGAKFYYMRGVLHNHPPHKVRKLLENTKSAMTQDSILLIDEMILPETGVNANAASIDMTMLTAFASMERTESQWQEIVQAAGLKLVQIYTYNPQSYESVMDVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEB5</accession>
    <name>A0A194XEB5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_667608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072873.1">
        <property type="nucleotide sequence ID" value="XM_018212986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEB5"/>
    <dbReference type="GeneID" id="28822712"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_667608"/>
    <dbReference type="InParanoid" id="A0A194XEB5"/>
    <dbReference type="OrthoDB" id="3563597at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="138"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="361" mass="41456" checksum="BFE5B7C09393D424" modified="2016-10-05" version="1">MKFEQLQAHMSELRAGPNMSSIGSEAQIQLRGLLSLSEDVCQVISQQRILKGLAFEDMHGSEDEWSSEDESEADSENGTGDSSEGANDFSNNKDPASIEIDEQSSIEESDEEYSGRAVIRDRDSQELGLGGRRDSICSKPFVDWLASGNRFFHVCGKLGSGKSTLMKFLCDHKRTQEELEKWAGDDRKLVFAKFFFWRPGSMLQRSISGLLRSLLHDTLKVCPDLISAVLPDQWNNVKSIPWQMQHEPEFGNQETRSAFTRLIENRNMTRHHRFCFFIDGLDEYEETRQEDYKDLLDLLSKWTEAAPDDVKLCVSSREDNVFVNNFSSEQRIRLQDLTKMIYITLFERGWQLPPPKNTTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XF12</accession>
    <name>A0A194XF12_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_717275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073079.1">
        <property type="nucleotide sequence ID" value="XM_018218336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XF12"/>
    <dbReference type="STRING" id="149040.A0A194XF12"/>
    <dbReference type="GeneID" id="28828062"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717275"/>
    <dbReference type="InParanoid" id="A0A194XF12"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="490" mass="53828" checksum="AE7A6B77720513A0" modified="2016-10-05" version="1">MLPPPTLTFTIPSIQDNLVLQCRVYHPTCLAPTSVSQLEEWQKKAAIVAHPYAPLGGCMDDPVVDVIATLLLKQGFVVGTFNFRGAGTSKGRTSWQGKSEQQDYISFIGFMVYYLHQLSPPTLPHDMPNFTLSDPELRDLSPIPSQIVSPTRKRSFPNFTTSEPHNENHNPNLPSIALDREATPEPSTKPVLLLAGYSYGALITSLLPPILTSLLTPFQTSSPGSAYAEIRLRSSSLAASQNLYIKSTISSLLSTHRRGRSLYADSLASPKLRKSSGGVRMGGEEDLRRASHESHRSRSSFAVEAEEIVRKSVDRVRSIGKHHRNDSYEKRFSPRRQNTQGSVTSQKSVGGESVFSNETDGGGGGEEEDRQVEKCKPIPALGQDIQTAYLLVSPLQGFVHGLATMFSAKLCAEHEVKLTVDPTLAIFGDDDVFVSIKKLRAWAKRLNGSGSGKEESRFRFVEVGGAGHFWHDRGAVRILQDEVKGFLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFS0</accession>
    <name>A0A194XFS0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_643579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073346.1">
        <property type="nucleotide sequence ID" value="XM_018211801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFS0"/>
    <dbReference type="STRING" id="149040.A0A194XFS0"/>
    <dbReference type="GeneID" id="28821527"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643579"/>
    <dbReference type="InParanoid" id="A0A194XFS0"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ18991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="864" mass="99021" checksum="85FDA549B283CC53" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGY6</accession>
    <name>A0A194XGY6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_581211</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073749.1">
        <property type="nucleotide sequence ID" value="XM_018209102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGY6"/>
    <dbReference type="FunCoup" id="A0A194XGY6">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XGY6"/>
    <dbReference type="GeneID" id="28818828"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581211"/>
    <dbReference type="InParanoid" id="A0A194XGY6"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ19394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="357" mass="40874" checksum="92A735CF528B922E" modified="2016-10-05" version="1">MGLTGSASRSFLYGLNHTEVVGLDRFMETLDRRRNVEERQRGLITGSYYSAVLMDDPLIWGVLPFKYAFNPSNHRWSLGSYDICFTNRVLKAFFNIGQVLPTHRSLHSIHGGLFQPTITQAIRLLSSQPFAPSPPSHPTIWEPIDTADPFTSGTLTYSTNGIDSFPSPSFFPSQKHSWIHIFPEGRVHQHPQKSLRYFKWGVSRLILESEPLPEIIPIFIDGNQEVMHEAREWPRFVPRTGKKIKIAFGESVDGEKVFGELRAKWKRLVRLQKEALMKRGESTDWQMGELTDGLKYGNEAVELRKEVTMRIRNEVLKLRRSLGYPDEDSKQGLVETWLEEGPKQIGKMEDGSWVGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHX2</accession>
    <name>A0A194XHX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_546407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17975" checksum="5E03314B595E1E44" modified="2016-10-05" version="1" fragment="single">SFEDPIRRELLTQELDTAEDYEPISYAWGDPTMSHEIMCNDCSLFITKNLFQALRRFRGTQPRFLWADGICINQSDEAEKSSQVSFMSRIYEKGYQTLIWLGEDDEHDGWAMSASATSNLISWQELDGLHCLSHLFRRPWFSRIWVINEVGLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI24</accession>
    <name>A0A194XI24_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_683262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073772.1">
        <property type="nucleotide sequence ID" value="XM_018214668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI24"/>
    <dbReference type="GeneID" id="28824394"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_683262"/>
    <dbReference type="InParanoid" id="A0A194XI24"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="185" mass="19045" checksum="57643E831FBA7EAB" modified="2016-10-05" version="1" fragment="single">MTYANLQNYLSGRPGSDPATSVVNRGGSTSSPHSGESPDVPSEPSSVWDSGMKSAFDANNRSPQLGSLTPSANPNNLFDQTGLGQFSTGASILSGRTQPIQSSSGNTMQVPIRSSTPGHPSPPPGFPWSNTGAVVGADLDRQSAQPPHTQPPTNTTSNLPGSSSQRLDLKSWISGPTFPTIGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI99</accession>
    <name>A0A194XI99_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_779781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074243.1">
        <property type="nucleotide sequence ID" value="XM_018222325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI99"/>
    <dbReference type="GeneID" id="28832051"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_779781"/>
    <dbReference type="InParanoid" id="A0A194XI99"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="547" mass="60372" checksum="5DF59F3DA1FE259B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIQ3</accession>
    <name>A0A194XIQ3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_695588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074354.1">
        <property type="nucleotide sequence ID" value="XM_018216771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIQ3"/>
    <dbReference type="FunCoup" id="A0A194XIQ3">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIQ3"/>
    <dbReference type="GeneID" id="28826497"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695588"/>
    <dbReference type="InParanoid" id="A0A194XIQ3"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="51" mass="6281" checksum="4E9DD7E43295C1E6" modified="2016-10-05" version="1">MPSHKSFRTKQKLARAQKQNRPIPQWIRLRTGNTIRYNAKRRHWRKTRIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJE9</accession>
    <name>A0A194XJE9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_695518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074242.1">
        <property type="nucleotide sequence ID" value="XM_018216767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJE9"/>
    <dbReference type="STRING" id="149040.A0A194XJE9"/>
    <dbReference type="GeneID" id="28826493"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695518"/>
    <dbReference type="InParanoid" id="A0A194XJE9"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="479" mass="52319" checksum="DEB6E7E6853A80A1" modified="2016-10-05" version="1">MTSSAQQRLEAIQKTIAPTSTSQAENPPFPYPVPNSTVSFWRTELHPLDSHRSTPELPESCDVVVIGAGYTGVATVHHLLEGREERDAGRGIVVLEAREACSGATGRNGGHLKPDVYFNIPKYQKMYGPTMATTIAAFESSQIHAVKALVDKEKIDCDFTLTRAVDACLDQAHADKALAEFEALVESGEPSTRDVCCKVGKEAEALSGVKGAKVAFSFTAGHVWPYKMVMHLLQRAVDRGVNLQTNTPVLSISDTASKEGYYTLTTQRGPLLAKKILFATNAYTSSLLPSYTEKIVPVRGICTRITCPPGTTPPYLPNSTSVRYGPGWYDYQIPRLDGSIVVGGARHKFMHDLKEWYNVTDDSRLIEPAVSHFENGLMQNTYSGWENSGAKLDRAWTGIMGYTSDLMPHIGAVPGKANQYICAGFNGHGMPLILLATKGVAKMIREDCSFEETGIPGAFKTTEERLKDKQNAILDSKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJY3</accession>
    <name>A0A194XJY3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_578390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074890.1">
        <property type="nucleotide sequence ID" value="XM_018208940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJY3"/>
    <dbReference type="FunCoup" id="A0A194XJY3">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="28818666"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_578390"/>
    <dbReference type="InParanoid" id="A0A194XJY3"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="113"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="610" mass="64642" checksum="8C838D1819F3C31E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJY4</accession>
    <name>A0A194XJY4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_716543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074452.1">
        <property type="nucleotide sequence ID" value="XM_018218271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJY4"/>
    <dbReference type="GeneID" id="28827997"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716543"/>
    <dbReference type="InParanoid" id="A0A194XJY4"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="128" mass="13866" checksum="F21A00D8C2192690" modified="2016-10-05" version="1">MPRVLRSSKTALLNSNGGSNTKSRKATRNRSATGVKGKRSTSTFVPAPASASANRILSKNCGECNRRRKKCDREKPCGWCKKRGILCRYDQTVTEGRESDPVLLKDLNKAKGKGKAKGKGKAKSKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKZ7</accession>
    <name>A0A194XKZ7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_695105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074802.1">
        <property type="nucleotide sequence ID" value="XM_018216748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKZ7"/>
    <dbReference type="GeneID" id="28826474"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695105"/>
    <dbReference type="InParanoid" id="A0A194XKZ7"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ20447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="353" mass="38530" checksum="D05C1E084248E6A9" modified="2016-10-05" version="1">MAIKTLPPLPTSRQAVVQSAKNPGSFEIETRPLPVPSPTQILIKVAAVALNHCDWKMPGRVPCPGAVDGGDYSGTVVRLGETAALTSGLKIGDRVAGAQMASSRRRPWVGAFTSYIVEEADCCWLVPENLSWEEAASVGCAVTTGLPGTPETPILDPKFVLVYGGATASGTFAIQLSGYRVITTCSPKNFKLVEDYGAEKAFDYHLSTCGEEIRAYTNNTLEYALDIITEARTIRQCYAAIGRGGGKYCGFELLPEDLIATMRKFVKADWVLGLEMTGLEIDLPGGYYRKENPELHAWFVDWMKRYAALLAEEKIKPHPIKVNKGGLPKVIEGVEAMRQKEISGVKMVYPMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLB5</accession>
    <name>A0A194XLB5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_577492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075385.1">
        <property type="nucleotide sequence ID" value="XM_018208896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLB5"/>
    <dbReference type="FunCoup" id="A0A194XLB5">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XLB5"/>
    <dbReference type="GeneID" id="28818622"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577492"/>
    <dbReference type="InParanoid" id="A0A194XLB5"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="9">
        <location>
            <begin position="303"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ21030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="572" mass="63004" checksum="B77CC243C52CC0B2" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XLG2</accession>
    <name>A0A194XLG2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_609265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075326.1">
        <property type="nucleotide sequence ID" value="XM_018210515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XLG2"/>
    <dbReference type="STRING" id="149040.A0A194XLG2"/>
    <dbReference type="GeneID" id="28820241"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_609265"/>
    <dbReference type="InParanoid" id="A0A194XLG2"/>
    <dbReference type="OrthoDB" id="5427204at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="673" mass="74429" checksum="E6CA8CA09F1B1895" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM03</accession>
    <name>A0A194XM03_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_705116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075630.1">
        <property type="nucleotide sequence ID" value="XM_018217429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM03"/>
    <dbReference type="GeneID" id="28827155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_705116"/>
    <dbReference type="InParanoid" id="A0A194XM03"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25704" checksum="63872AFF0175CEA7" modified="2016-10-05" version="1">MAPKISARISLRWLPSTEAPSEPTDTIVFGVGAYFVDLRVLKTDNTIDWALAGERQIVSTDPLKVRWIKTLDSLGLTEEPDEGDFTTLPNGDSLETGAMPCPEKGMAVTQYEEVWQVLAPQSGPDGEKGSAWILESIDAADTMKTFLGRIGGSYMAMRGKTGEAWKEGEFGARSEEWDASDRKWKNKHVIGYIAGLPSPAELGTGLFAGEDTWKEGDKVAVLGQEYIVRAFEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM61</accession>
    <name>A0A194XM61_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_770466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075581.1">
        <property type="nucleotide sequence ID" value="XM_018221849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM61"/>
    <dbReference type="GeneID" id="28831575"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_770466"/>
    <dbReference type="InParanoid" id="A0A194XM61"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ21226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="33931" checksum="CB3C20EF494CBAE1" modified="2016-10-05" version="1">MSSVPLHRIDQLQGSLRKTPNTPTFSLAVTRTIWTTGPPMPGFQLRDKEYRSYFVHIYKELTAAACSGDSQIPDLTHKQILEIVQQLKVHPCTKSEAQDFFRSASNNNDAQRIERAVILAAGLLVPLNFKAGGGARRGATVSWENNDTLSQMAEKEFAARLQTSSAARTKCPSCNRVTKFPRSFNARQLTRIAGFEIIWTNNLLDHLLLEDDDGTLKVYIFHQAKILEHHLSLANTIIPSKLSKETLHTLAMLIPRSDRRVRKWYKGLQKTHVLDPGVLSLEYLKPELRDIDHFKFWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMU5</accession>
    <name>A0A194XMU5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_378222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075940.1">
        <property type="nucleotide sequence ID" value="XM_018207108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMU5"/>
    <dbReference type="GeneID" id="28816834"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_378222"/>
    <dbReference type="InParanoid" id="A0A194XMU5"/>
    <dbReference type="OrthoDB" id="3561020at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="277" mass="31990" checksum="8D8F26A612C773FD" modified="2016-10-05" version="1">MATSSISNLVTLGGTKQSVDTQPLPSQQTFTCFPTLPVEIRLQIWKFAAHISRNVDLHIAEQYRQPRDSYCPNDTICFYASHTRVPAVLFANLESRKESLKWYNFEFDMKSALSREDDFHRSICINWAVDRICFKMPVSRAGETKFSDMYPTIIDRCKAMHIRSLAVIVDARNNPNSHTYWFIATFRFLDEILLLADTEEAAVLWASERDQGFDIIPFPDGCPSPRMLKLGRYPFVIFDKYMQILSNSWATAAEYEQLAGIEIKTRPQVKMMRIFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XN36</accession>
    <name>A0A194XN36_MOLSC</name>
    <protein>
        <submittedName>
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        <name evidence="5" type="ORF">LY89DRAFT_704470</name>
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        <name type="common">Conifer needle endophyte fungus</name>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 120377</strain>
        </source>
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            <end position="923"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
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        <source>
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</entry>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="294" mass="32442" checksum="216261D0466D1801" modified="2016-10-05" version="1">MVDQNQRPGKVATNNKVAAESSSAAPASRSAHRAPLSQSAFNPGSPTKVDITYVRLPGASADITLSATGATLNKYKSTKSTYSNGLATYVKAYPFQNQGFDFVAHFMKAMSPADRVDFLAANWVEVVVELRAYFANASNVVNQLAKLGPEFTDHIKNLDIKLKLPPLAELSKMTLALLPASAGYKLIEEVVQEIFQFPAIGRMNVVLCIPHSIQDGIHDQHLSHALPFFPMSFTGWNVDIQAQGMYKPKLILREDLNSLNGLRAIEVKRKEDEELRVLNAVFVRHSIYEPETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPJ7</accession>
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="83" mass="9669" checksum="051486C37C7CC6F0" modified="2016-10-05" version="1">MLQQEFSDSPNEAVGEEGEKRKWVSDIRGQVEAILYHLEVAGRREERHRKREERDDMLDEQRNRVDDWLESITVSGADPNSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="107" mass="11543" checksum="3A78BBFD3549D106" modified="2016-10-05" version="1">MSDFALSSSQANAEISASDATTVDGQSFWDNDNLRGRLQAALRQEIRNRLHPNKEVEAYWAKKDAAAKLALKAILGGGDEDEAMNDAGESEARGELAATIDHMHVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQS1</accession>
    <name>A0A194XQS1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_714214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076759.1">
        <property type="nucleotide sequence ID" value="XM_018218111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQS1"/>
    <dbReference type="FunCoup" id="A0A194XQS1">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XQS1"/>
    <dbReference type="GeneID" id="28827837"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_714214"/>
    <dbReference type="InParanoid" id="A0A194XQS1"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000132">
        <property type="entry name" value="Cell-cycle checkpoint serine-threonine kinase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="281"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="679" mass="76038" checksum="3BBFEEDA6E3EC40F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR38</accession>
    <name>A0A194XR38_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_680770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077008.1">
        <property type="nucleotide sequence ID" value="XM_018214135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR38"/>
    <dbReference type="GeneID" id="28823861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680770"/>
    <dbReference type="InParanoid" id="A0A194XR38"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="28954" checksum="3C6B1387EAE682CD" modified="2016-10-05" version="1">MASNNAPWADAPFALIPTPGDGQDLNRLHEAVFLAREMACAHNGMLRSLNSIYQQCVHVSESQDILDLLQYSKFWCAWLEEHHEAEEKWYFPDIERITGVEDLMAGMVTQHKDFMPGLEELTKYVNETTVEAYDGRELRRIVDDFGAILTKHLTEEVEVLAALEVHDGPALKHAYLEFDKELRKGDKSVLFPMVLGSTDRTYEKGPMWPPVPDFLKYVVHYWFERKYQGAWRFSPSTTWGEKRPLLCLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSP4</accession>
    <name>A0A194XSP4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_713725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077573.1">
        <property type="nucleotide sequence ID" value="XM_018218072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSP4"/>
    <dbReference type="GeneID" id="28827798"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713725"/>
    <dbReference type="InParanoid" id="A0A194XSP4"/>
    <dbReference type="OrthoDB" id="5425648at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="497" mass="54156" checksum="0B8EF54A4B0ABF73" modified="2016-10-05" version="1">MHGHMKVVKPIGYEMKSKLESEDNSDSESVSSGSSPTFHPNDWQSIRKTQKSFYLVLPIAFFASFSMAITNPSTLFAYATLLCKDALACQKEEENSYSGTFAASTAVTNLCGILVLGILPLLRRMSTKAPLYFWLISRAHSVGFLMLGVYFDNLWIALCGRVFEGFAKDNILQLCLNAIFVHAPGYNQVSQFFALSLALFMLGQALGSSVAGIFSDFRTSFVLAIGMFALCIIYLFLAIPENKLAGSTREITDGEPSDHESMGRPSLIRNFVVSVRSLFGEPALLPLQFTLLLYFGGASYTLSAVMVYASLRFQFTVKENGWLVSTAATSGSIYLFGILFILRKICHSKADAKAFVWSSRKRPPPDFWFGIASLALFALAVPCVGLAYHGWHLYPIIAVTAMGFSTPTFIRTYAVSLVSDGTQAISSLAFMEASGALISPLILGAVQSKIGVKTVFVVASGMVIVGTLSLLGSAFWRGFGRRKSAIRAIDSVDYQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTB1</accession>
    <name>A0A194XTB1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_713899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077798.1">
        <property type="nucleotide sequence ID" value="XM_018218088.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A194XTB1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XTB1"/>
    <dbReference type="GeneID" id="28827814"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_713899"/>
    <dbReference type="InParanoid" id="A0A194XTB1"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
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        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="545"/>
            <end position="650"/>
        </location>
    </feature>
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        <location>
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            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1319"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="1107"/>
            <end position="1133"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1628" mass="182725" checksum="8C27C65DC8F4FB9E" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU69</accession>
    <name>A0A194XU69_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_744404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078220.1">
        <property type="nucleotide sequence ID" value="XM_018221035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU69"/>
    <dbReference type="STRING" id="149040.A0A194XU69"/>
    <dbReference type="GeneID" id="28830761"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_744404"/>
    <dbReference type="InParanoid" id="A0A194XU69"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268612" evidence="1">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="208" mass="22267" checksum="E8AE5980282D7952" modified="2016-10-05" version="1">MKFTTSLLTLAGLASLAIASAIPGTAELPSCGYKNYPTGIMTFKGTIDGHQVQLNGSAQEINTQMTAKFPGFNPDALVAAKFASRDAAVNLFARNKSPPVLCWPVAGQDWSFCNAATIQDGINYLDNFDGLCGVPGTTCVRISCSYNAAIYLCNDNAYGITPNCAYMASYATDIINDCVFYDDQGNAYVCGQEFDTDGYNIIVREDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUK2</accession>
    <name>A0A194XUK2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coagulation factor 5/8 type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_692736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078171.1">
        <property type="nucleotide sequence ID" value="XM_018216588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUK2"/>
    <dbReference type="STRING" id="149040.A0A194XUK2"/>
    <dbReference type="GeneID" id="28826314"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692736"/>
    <dbReference type="InParanoid" id="A0A194XUK2"/>
    <dbReference type="OrthoDB" id="5186230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268626" description="Coagulation factor 5/8 type domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30475" checksum="17FCBA0F20C07FF2" modified="2016-10-05" version="1">MELHTSILILFHTLLISHVSGTDVLKSDTVSLTTSGFNSLIIFNIGILANGDIMYYSNTAGSKDTLVASNGSYIGGSPLSDKVRSFKSGNNTGIDRVEISMNSQHVKDLMSSPGPGNSTTLYQNFEALKMAWNLDAVNNDDESIYDVDSTVAFARMLGGIGYKYTIAPYTNTAFWVSVKTKINSGLDSPLLDRVYLQCYDGGAGNDPKSWQSSLGMKVVPLVWVTNDSKPSQGTTAAQAKSRFAGWNKGAALAGGGYWNDYDIERMKSSYAAYGDVLMNVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWP2</accession>
    <name>A0A194XWP2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_26448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079013.1">
        <property type="nucleotide sequence ID" value="XM_018206302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWP2"/>
    <dbReference type="STRING" id="149040.A0A194XWP2"/>
    <dbReference type="GeneID" id="28816028"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_26448"/>
    <dbReference type="InParanoid" id="A0A194XWP2"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="529" mass="59181" checksum="4A66F77BD2B0C6B7" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XX19</accession>
    <name>A0A194XX19_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_634822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078969.1">
        <property type="nucleotide sequence ID" value="XM_018211410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XX19"/>
    <dbReference type="GeneID" id="28821136"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634822"/>
    <dbReference type="InParanoid" id="A0A194XX19"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="518"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73429" checksum="B3A4870703D7D142" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B237</accession>
    <name>A0A132B237_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_412770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060658.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B237"/>
    <dbReference type="GeneID" id="28817069"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_412770"/>
    <dbReference type="InParanoid" id="A0A132B237"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="162" mass="18156" checksum="00805F105E3B0D96" modified="2016-05-11" version="1">MSLDLLSDDLVLDIIDLVSYNTRCLCDIARSSKRLNDLATPFLYKEIDLGTWNGEILLLRALLGNPRLGYVNLSALNILDTFTLYAVLCSKAQSSNVLPLSCPADHVTSKHCKSFTSCRNTWKTATDRSLTPSEQALVPTRISKYCTTPEEVQKWLLDLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B289</accession>
    <name>A0A132B289_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_410620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060870.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B289"/>
    <dbReference type="GeneID" id="28817045"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_410620"/>
    <dbReference type="InParanoid" id="A0A132B289"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="225" mass="25934" checksum="C11BC8DE07AA478D" modified="2016-05-11" version="1">MSRQGRSRQEYLDAGFTSTQITKAKAYRRTIESANARQSLEDKALEDAETRPFNRNDLRGLYFILLNLFPKAGKDAIADAIDPSWQLTPHSDELQDDSSFDEIVGHLSLLRFSYECWNKVFSVDRQTESQFWLFSEPFAHNTADEKNVWGEEDDMRSFETLSTFTDKPAENDNGPSTDRLGLFVTKTKGSVKDKNWHRTPFHGWVAWLSERGQGLSTRHFRSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2C9</accession>
    <name>A0A132B2C9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_412122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060758.1">
        <property type="nucleotide sequence ID" value="XM_018207333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B2C9"/>
    <dbReference type="GeneID" id="28817059"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_412122"/>
    <dbReference type="InParanoid" id="A0A132B2C9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="19447" checksum="6C437FDB77BFE46B" modified="2016-05-11" version="1">MGHLANAFVISTRNLDRYGSGEKYRQGGSLQPLYFPIYASYFARLYIQYGAIPTAIFLHVSSSHGFPDGMPVALFVPFLFLGAYKVGGLLFKDFYIVAIIEDFSHLGYMWISDASDIFVHTVPTLGASDPVSCRCNSSSSKFESRTMRCRTSTQYGRRTFPPTAFPYSIFPNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B308</accession>
    <name>A0A132B308_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_692151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061143.1">
        <property type="nucleotide sequence ID" value="XM_018216475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B308"/>
    <dbReference type="GeneID" id="28826201"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_692151"/>
    <dbReference type="InParanoid" id="A0A132B308"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="368"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="876"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123783" checksum="5596DBF670F2715C" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B385</accession>
    <name>A0A132B385_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_790241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061220.1">
        <property type="nucleotide sequence ID" value="XM_018223348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B385"/>
    <dbReference type="STRING" id="149040.A0A132B385"/>
    <dbReference type="GeneID" id="28833074"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790241"/>
    <dbReference type="InParanoid" id="A0A132B385"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="273"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="684" mass="76763" checksum="CA640937B7A2B062" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4C4</accession>
    <name>A0A132B4C4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_712600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947446">
        <property type="protein sequence ID" value="KUJ06517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060872.1">
        <property type="nucleotide sequence ID" value="XM_018217991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4C4"/>
    <dbReference type="STRING" id="149040.A0A132B4C4"/>
    <dbReference type="GeneID" id="28827717"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712600"/>
    <dbReference type="InParanoid" id="A0A132B4C4"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF29">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="327" mass="35489" checksum="64B0FCCE6FD7E680" modified="2016-05-11" version="1">MASKKIIVVVGATGKQGSSVAHTFLKLPEWHVRCLTRNPSSSASQALSALGAEVVQGDLSDVSSLSQAFSNANTIFLNTDFWENFVAAGKAPQQGISSDKAAFQKEILYGKNAVQAASAVPSLDRIIYSAIPGVTKGSGGKYSVHHADSKGTIVEYILDDSNLAKKASFIYLGAYTTNALLAPRFIGENYAFVLPFSKSDTFPIIDPEHSTGPFVCALLDEDVGTNLLAYDSYLSFGEVQDLWSKASGEDAGYMQATVEMFRAQGVSEEMLNALEAMKEFGYMGELNFIEPSQLKSKVQTKSFEQWLKGRDWEEVAMPTLNTGRTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B4R1</accession>
    <name>A0A132B4R1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_790008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061588.1">
        <property type="nucleotide sequence ID" value="XM_018223321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B4R1"/>
    <dbReference type="GeneID" id="28833047"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790008"/>
    <dbReference type="InParanoid" id="A0A132B4R1"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF10">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="227"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="959" mass="107955" checksum="03116B9063E23518" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B539</accession>
    <name>A0A132B539_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_691615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061877.1">
        <property type="nucleotide sequence ID" value="XM_018216371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B539"/>
    <dbReference type="GeneID" id="28826097"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691615"/>
    <dbReference type="InParanoid" id="A0A132B539"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287873" evidence="2">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="99" mass="10896" checksum="2919D0CF5AC13D7A" modified="2016-05-11" version="1" fragment="single">MNLRLIIFATLLMALVPTSNTITAESQNEHLPLNMREFPIISTRPRVPISMRTYVSRENARRAQLSSEAAGGLVVGGIAGCFILVCIAIGLCRHIFGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5K6</accession>
    <name>A0A132B5K6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_659925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062045.1">
        <property type="nucleotide sequence ID" value="XM_018212532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5K6"/>
    <dbReference type="GeneID" id="28822258"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_659925"/>
    <dbReference type="InParanoid" id="A0A132B5K6"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="443" mass="48604" checksum="F217D902B3E0793D" modified="2016-05-11" version="1">MLAARDQENLVHGHQQVAASKPLNQTTRGLQPKTPGNKYPKTPLRIPLNDENAPTGFGKTGKGKGLDNLVSGKKIATFDKNAFITPMAPRERAPLGAKTTNAKAKAFQTPAGPTLGKELEKSKPKQTSARRPKKVIHADTVKLEVHGDESPLTERDVEYCPPKPKELPFECDDFPDGCLNYSALKPENMMRDIYQSYYQPMLKRQAAKHDKDSQDLYDKVMKEHDEGVMKMMEEDWTVGDVPEAFRHLRKKQIQPQDKPIAKSTEQIKKPTAMSNKGPATITSRKAASALSVAPKAAPVAPKASKPAPKASFLYRSKAPVVPSLPSNTSSMRHTAATAASRSTIGYTKGRSASGALNANTFKPERSGLQRSVSNMSQGSDTTITPANFKDAEPEWKNPSFLKAFEVDDDELEPGLRGVLPESLRRMDGDEEEFVMPLPSSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5P9</accession>
    <name>A0A132B5P9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_712245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061569.1">
        <property type="nucleotide sequence ID" value="XM_018217965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5P9"/>
    <dbReference type="STRING" id="149040.A0A132B5P9"/>
    <dbReference type="GeneID" id="28827691"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_712245"/>
    <dbReference type="InParanoid" id="A0A132B5P9"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ07214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="41491" checksum="C31693F5F0B9C766" modified="2016-05-11" version="1">MPSRLPEIKVTPITPSAGSKVDYGAIVTGLDLKNLDDASFKALEDAIYTHKVVVVKDQQDLVPLKQFELIHRFDPDTKPVHGFGDPDAYKDNEFVKLVVPNSGGVRLVGKGYHGPDHYGLKDLIVPTVNDYNKLHGSNLDPEEFASGQTRFFTLRCIQAPKGPDLTVRWDNGSGLTMKTKPGETAFVSGVQLHNLLSPEDQMLADHSRRELAPHPYTWKGTRKYRSTGMGLEKGGEVLPLDKLPAWTPDKVHTYPMIWVDERTGEKASQIMPTCVRKLHLRTSFDEKERVVEDLEEIRLLLNGWMDKILRPEYICFPPVEDGDVAMWNNYIWSSNIDREEAYIPLWKNPPVPRHTSISFIFSSEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5U0</accession>
    <name>A0A132B5U0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_677879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061609.1">
        <property type="nucleotide sequence ID" value="XM_018213708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5U0"/>
    <dbReference type="GeneID" id="28823434"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677879"/>
    <dbReference type="InParanoid" id="A0A132B5U0"/>
    <dbReference type="OrthoDB" id="3434684at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ07254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="115" mass="13359" checksum="27D17EEE60B1E856" modified="2016-05-11" version="1">MDPEINTAPLQFHEEDGYSMNSLMNRLDEFQHAQQWECLERLTLENSWLEQHVTRHREKSARVAFLLREIEGAANEMQRALEACCSEEVAADRAWLAFWHVREKQGAASGNGSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5U9</accession>
    <name>A0A132B5U9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_677888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061619.1">
        <property type="nucleotide sequence ID" value="XM_018213710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5U9"/>
    <dbReference type="GeneID" id="28823436"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_677888"/>
    <dbReference type="InParanoid" id="A0A132B5U9"/>
    <dbReference type="OrthoDB" id="10490427at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287876" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15627" checksum="C57FF70956C98AF3" modified="2016-05-11" version="1">MRPTILLALLSASTISARVIPAWMLSPPASSNIGRNLDDSTIIRDTDEPTIIRSGGKSIGIRSLDESNVIRSEDDTIIRSLDDSNIIRSEDDTIIRSLDESNVIRSKDDTIIRSVDDSPIIRSEGQGKIIRRDDVEIVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B636</accession>
    <name>A0A132B636_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061709.1">
        <property type="nucleotide sequence ID" value="XM_018220904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B636"/>
    <dbReference type="STRING" id="149040.A0A132B636"/>
    <dbReference type="GeneID" id="28830630"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742986"/>
    <dbReference type="InParanoid" id="A0A132B636"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25900" checksum="B63B074D13EC7955" modified="2016-05-11" version="1">MDRTDLHCEEKQDDTCIRMDSGLTTQAYPSLSSTFWQKPHSRFVIVLVGADEVPFGIHKDVLCARSPFYGGELATLDQNGLELVCKLPDTDIEAFGCLQSFIYTGQVYRMKSGDSIPDFSVLFRAWKLAKTLKMAHLQTNLLDCMAVRHYQMASIPGVQIIKEAWEDTEEGCPLRIKLMDWMAEYMRDGNGAAKLAKRLPNEILSELCMLIARPPAKPTPESLAELLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6C2</accession>
    <name>A0A132B6C2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall biogenesis protein-like protein Ecm15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_691995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061582.1">
        <property type="nucleotide sequence ID" value="XM_018216447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6C2"/>
    <dbReference type="FunCoup" id="A0A132B6C2">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="GeneID" id="28826173"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_691995"/>
    <dbReference type="InParanoid" id="A0A132B6C2"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="118" mass="12711" checksum="28D3C0B6A1850323" modified="2016-05-11" version="1">MSEKIEYTNLPTPPACVADFCLIPIGTPTASVSNEVAAVQRLMKASGLSYSMHSAGTTVEGTWDEVMRLIGQAHTLVHQNGVLRVQTDIRAGTRTDKKQHFSEKVTKVKSILAADGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B794</accession>
    <name>A0A132B794_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_600331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947437">
        <property type="protein sequence ID" value="KUJ08113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062468.1">
        <property type="nucleotide sequence ID" value="XM_018210153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B794"/>
    <dbReference type="GeneID" id="28819879"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_600331"/>
    <dbReference type="InParanoid" id="A0A132B794"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ08113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56056" checksum="B667AC10DB514BEC" modified="2016-05-11" version="1">MQPLDHKASTSTITTTTSSSTDLATEKDHKSSTSTIVVTTTTCSSSDLELEKAPLQITHVLPAEKLDQRPFRQLRHVIFTVYRRLFTFVIIANIVALIIVDIRPRDTKFYFKAISSAASANLFLCVAIRQDYIINILFDVFAATPKSAPLRFRRILTKVFEFGGVHTSAGICSTAWFIRLAIFLTLSFENGSLRDVPILALTYVLLLLFSGIVIFAHPKMRSKTHNTFERMHRFGGWLCSVTFWTLIVLTARVMADLPGSKQSTIEVLIHLPSFWLLSINTIHTIVPWLRLRKLEATPEKLSDHALRLHLKANIGGFYTVRISDSPLSEWHSFACFIDSKPVNGSTNSVVISRAGDWTSKTIAEPKSYYWIRGLPTRGVLYMSLTFRSVVVVTTGSGIGPCLNLLSMHASTRPACRVLWSTPKPLATFGQEICDDVKECDPAAVIWDTKKFGRPDMVGLTWQLLKESQAEAVFVVSNPKVTKMVVYAMESRGVAAYGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7S9</accession>
    <name>A0A132B7S9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062092.1">
        <property type="nucleotide sequence ID" value="XM_018220830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7S9"/>
    <dbReference type="GeneID" id="28830556"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742509"/>
    <dbReference type="InParanoid" id="A0A132B7S9"/>
    <dbReference type="OrthoDB" id="10431695at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287959" evidence="1">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="139" mass="16062" checksum="319BBBA5D2D194BD" modified="2016-05-11" version="1">MRIVNGLALWLLMASTCCVAAWDFGLNERTKSECQLVDFDTLQAIKRDGHNFHIGPKGFYINTKNGCFITEVDSSEFKTKQPKAYESWDYLMKLANGEQMEEKEDYTIIPAEREIDRSTTLNIALILWFILSRVFPGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B7Y9</accession>
    <name>A0A132B7Y9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_658826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947435">
        <property type="protein sequence ID" value="KUJ08481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062836.1">
        <property type="nucleotide sequence ID" value="XM_018212493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B7Y9"/>
    <dbReference type="FunCoup" id="A0A132B7Y9">
        <property type="interactions" value="806"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B7Y9"/>
    <dbReference type="GeneID" id="28822219"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_658826"/>
    <dbReference type="InParanoid" id="A0A132B7Y9"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="6">
        <location>
            <begin position="61"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="5">
        <location>
            <begin position="201"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ08481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="859" mass="95819" checksum="CA54CAEF6F271A54" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B973</accession>
    <name>A0A132B973_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063307.1">
        <property type="nucleotide sequence ID" value="XM_018216115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B973"/>
    <dbReference type="GeneID" id="28825841"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690522"/>
    <dbReference type="InParanoid" id="A0A132B973"/>
    <dbReference type="OrthoDB" id="3495587at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16991" checksum="5F672CE0A4C127BA" modified="2016-05-11" version="1">MHFATVAKGLVLTKSHSHTHSDSTPADSTPPSAPEPVPHKINKITTLPEFEQILTDHHHRRVIIFCVTTTYRDPDVDEEGWYHHYEKLNDVHFVRVDLDESEELEERLKPRVRPCWFSFHKGQETGWSSGGMKRFLQMHSERKGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9A6</accession>
    <name>A0A132B9A6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_315797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063306.1">
        <property type="nucleotide sequence ID" value="XM_018206669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9A6"/>
    <dbReference type="GeneID" id="28816395"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_315797"/>
    <dbReference type="InParanoid" id="A0A132B9A6"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="416" mass="43988" checksum="66E95A11424F45D1" modified="2016-05-11" version="1">MSRFSPDRVQTGPRSQSALTMAFQRFTTMLLHDRTAPIITAFASIVAFVLSLLALLSTSKQGGLIQYDLVMLNTSTIFQNAIKVETAGASGTSSASVAARAANVPYIPAPTAAPVLHGRDPLSLPSPSQVSSFFASIGSGLSSAVSPPQSTGTASTSSGTDSNGLLGDLESFFNALVGSATGAIGDEVVQVVNSIVADVTKALGVKDWYGLYMTGFCDGEYTSSDGMNTSSCTQYTDLHINSTNSTVQLGTTTLDFSALNIPAKLSASGGQIKAVLKTVLALQIIGIVSAGILIILAPLEILFSFFRRWLVHLVIGCLAALATACFAVIAFAATAIQVAVSSLVNDLGDGLGIEAYSGGNLLALVWISYILMEYAAVLWFIRWFIRWHAHRYVRREKGLGPSQRPLVRTAESRFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9K0</accession>
    <name>A0A132B9K0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_676452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063437.1">
        <property type="nucleotide sequence ID" value="XM_018213583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9K0"/>
    <dbReference type="GeneID" id="28823309"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_676452"/>
    <dbReference type="InParanoid" id="A0A132B9K0"/>
    <dbReference type="OrthoDB" id="36970at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ09082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="733" mass="81934" checksum="DCC327D3FEFC8460" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBK8</accession>
    <name>A0A132BBK8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_788259</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063744.1">
        <property type="nucleotide sequence ID" value="XM_018223155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBK8"/>
    <dbReference type="GeneID" id="28832881"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_788259"/>
    <dbReference type="InParanoid" id="A0A132BBK8"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007288100" evidence="16">
        <location>
            <begin position="25"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="125"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ09389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="481" mass="54146" checksum="C1F33BFE2ED3EDA9" modified="2016-05-11" version="1">MLLVVGRFLWVLFSIICFSGTALGQENLTEVLLSYPACSAKCSATYLPIANCAFTDLRSCMCTNYTLQYEIGACVLSTCNITDQIISSTITQNEICNGVPQPWEGGRAIRASIIIACFTFPIIGLRFITRIYITKKLWWDDWTILIATVLMLPNTAIPIYLSYHGLGLHFYDVHPADTPNLEKLFYISQIFYVLIQNIPKFSILLLYLRIFPTPRFRKMLFIAMAWQVAHTLAFLCGVAFQCVPVDSFWDPFIKKDHCIDIATLTYFGAGFSIFEDIVIMSLPVYELKGLNLSLRKRMALVFMFALGSFACVTSMIRLKFMIGFGKSIDSTWTNVDVVIWSQIETYTAVICGCLMCIRPLFIKYIPSVFSTKASQPSSSQLHSATWGARISSRIKAERTSRYGNRLDDEESIEVGKGLEAGNMERRGSQGNVIKVTTENVVQYEMKRTSERRAGSQDSDDIADELGLGSKENLNDRSVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBM8</accession>
    <name>A0A132BBM8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_724405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947432">
        <property type="protein sequence ID" value="KUJ09409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063764.1">
        <property type="nucleotide sequence ID" value="XM_018218893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBM8"/>
    <dbReference type="STRING" id="149040.A0A132BBM8"/>
    <dbReference type="GeneID" id="28828619"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_724405"/>
    <dbReference type="InParanoid" id="A0A132BBM8"/>
    <dbReference type="OrthoDB" id="3560230at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="316" mass="35137" checksum="003482DB46F8CCD7" modified="2016-05-11" version="1">MAIHPDLPGVEVTICVNGIPLEEFDDPPEEGTPFQPNTTKSISKYVKSMTDQEFTIKYTMGHPFDVDCPNLKVHVCVDGKSVPGKAFDRDRFPGGKIVEGIISGVKYVENGEKMFKTFCFSAVKTTLDDDAYKRVDKDINLMAKVGSIAVTLWRGGDAVRVSRKKDWSAKLRTSDVHEKALKGEPKYHGVSLGDAKPVAFKNTILRTAKLDETPLASFTFKYRSEGKSRVALKELLVIERTPEPEEPSPAPAEAVSFEDLDADQKRKVEEFMRNLKSGSSQAPGIKREFKTEDGPSSQPKRPRRLGEKVTIDLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BBU2</accession>
    <name>A0A132BBU2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_657434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947431">
        <property type="protein sequence ID" value="KUJ09866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064221.1">
        <property type="nucleotide sequence ID" value="XM_018212429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BBU2"/>
    <dbReference type="FunCoup" id="A0A132BBU2">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BBU2"/>
    <dbReference type="GeneID" id="28822155"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_657434"/>
    <dbReference type="InParanoid" id="A0A132BBU2"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090518">
        <property type="term" value="P:L-arginine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090515">
        <property type="term" value="P:L-glutamate transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090517">
        <property type="term" value="P:L-lysine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090516">
        <property type="term" value="P:L-serine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090514">
        <property type="term" value="P:L-tyrosine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="37"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ09866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="502" mass="54200" checksum="FC117DE4599B8493" modified="2016-05-11" version="1">MASYSAIAAPSGYTSDASRGRRRRSSRAMKDQNFGGQASWLSSNINLVNTIIGAGTLAMPLAMSHMGIVLGVVVILWSGLTAAFGLYLQTRCARYLERGTSSFFALSQITYPNAAVIFDAAIAIKCFGVGVSYLIIIGDLMPGVVRGFNESADSIPFLVDRHFWVTVFMLVVIPLSFLRRLDSLKYTSVVALISIGYLVILVVYHFAKGDTKADRGIIRVIRWGGLVQVLQSFPVIVFAYTCHQNMFSILNEIKDNSPRRTTSVIAASIGSAASIYILVAITGYLSFGNSVAGNIVGMYVPSIASTIGKAAIVILVMFSYPLQVHPCRASVDAVLKWRPYGLKSSRNSPNSSPARTVPLLTGASAQPIARNDTIGELRFAIITTVIIILSYTAAMTVSSLDKVLAYVGSTGSTSISFILPGLFYYKISSPDSIHHQRLSKDEDEADSGEEDEEGLLGQGNSRTMPWRKTILRKLSLALAIYGLFVMVLCLGTNMFFSGGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCA0</accession>
    <name>A0A132BCA0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_723760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ09893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064248.1">
        <property type="nucleotide sequence ID" value="XM_018218844.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BCA0"/>
    <dbReference type="GeneID" id="28828570"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723760"/>
    <dbReference type="InParanoid" id="A0A132BCA0"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="14"/>
            <end position="445"/>
        </location>
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        <location>
            <begin position="837"/>
            <end position="1143"/>
        </location>
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        <location>
            <begin position="837"/>
            <end position="980"/>
        </location>
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        <location>
            <begin position="995"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ09893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1973" mass="216820" checksum="0582E4E2BEC05FDC" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BCL5</accession>
    <name>A0A132BCL5_MOLSC</name>
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        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_656754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212401.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_656754"/>
    <dbReference type="InParanoid" id="A0A132BCL5"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="102"/>
            <end position="124"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="300" mass="33686" checksum="D873024733D4649A" modified="2016-05-11" version="1">MHPQINLLALRDHAPNFTIPAQQCTLNTCSIIQGQLQYDPSLAGNAFFLALFASLLSTHILLGTYYRTWTYSVGLVCGLILELCGYIGRVQMHFNPFIQSPFFMYVISLTIAPVFLCASIYVCFNRLIIIFGTQLARLKGRALVSLFIASDFLSLLLQTGGGAIAVIADTESFEYVGIHLMMAGLALQVASLVIVLALAADFALRYWKKCYEWDEKFETIREKKYFRGFVFGLLLATVTILIRSIFRVVELTGGFHGRLWNDEVAFMCLDGTMVATAYIFLTVFHPGLAFHGRWELVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BES2</accession>
    <name>A0A132BES2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_596406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064864.1">
        <property type="nucleotide sequence ID" value="XM_018209922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BES2"/>
    <dbReference type="GeneID" id="28819648"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_596406"/>
    <dbReference type="InParanoid" id="A0A132BES2"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ10509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="676" mass="76027" checksum="A8FD7AE650947145" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BFT3</accession>
    <name>A0A132BFT3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_760559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064932.1">
        <property type="nucleotide sequence ID" value="XM_018221509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BFT3"/>
    <dbReference type="GeneID" id="28831235"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_760559"/>
    <dbReference type="InParanoid" id="A0A132BFT3"/>
    <dbReference type="OrthoDB" id="3557569at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="305" mass="35359" checksum="7D12B85BA5F1F2F3" modified="2016-05-11" version="1">MSLNNCKQNGPTKMPLDNPMFTLFNRLPTELRLKIWEAARPGPRVVNIKERLVERNGQPTWALWSPSKAPSPLFACRESHHVALKFFVPCFAFASSIPETYFDFRTDTCYLRFDAFADDCADVFEFFIQRLERIYDTDHVRQVQNLAVLLNPEDVSARVYQLAQILSFFGSIQKLTVVVGHFDREEDDQGDILFIEAIDVTKTIQNYEALSQEPPQFHETMETPLAMDLISPAELESSLENRRHFNRILTQERIEEGREVEDLGDIPMPHIEYKSVITGSLKSRLDSLREEYRQKIKEHDDQSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRM7</accession>
    <name>A0A194WRM7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_655400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065011.1">
        <property type="nucleotide sequence ID" value="XM_018212340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WRM7"/>
    <dbReference type="STRING" id="149040.A0A194WRM7"/>
    <dbReference type="GeneID" id="28822066"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_655400"/>
    <dbReference type="InParanoid" id="A0A194WRM7"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25866" checksum="7EB0EC11C9E8417C" modified="2016-10-05" version="1">MASAKHLTMLVARGRPAARLTNSVRPFAPTTSSLAAFSTSTLRAYATPSGPPPPGFRLPKPERWDESKESSLDKAGKYFLLTEMARGMYVVLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEEREDGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAAARADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WS15</accession>
    <name>A0A194WS15_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_562647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065123.1">
        <property type="nucleotide sequence ID" value="XM_018208480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WS15"/>
    <dbReference type="GeneID" id="28818206"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_562647"/>
    <dbReference type="InParanoid" id="A0A194WS15"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ10768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24930" checksum="990F6B21278C046F" modified="2016-10-05" version="1" fragment="single">VYKECRVTESLLRSNFGQGTGASIIFLLPTIFIHRTPIIPALQLILKIIILGSIFQYTFDIVNQTTGVLEDTINKPYRPVPSGLITLRGAKKRWLLTWILSPLLTAAISGRYAALWQLVWQLDVGFCYAWPRPNGPITRNSFIVLGTLALVSHANAIAADQYPDRNMDFMLRSALSIWAGMVAHLQEFHDVVGDKASGKRTLAVILAPSRIWLVRKVTCLIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSQ4</accession>
    <name>A0A194WSQ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPC2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_723253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065002.1">
        <property type="nucleotide sequence ID" value="XM_018218799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSQ4"/>
    <dbReference type="STRING" id="149040.A0A194WSQ4"/>
    <dbReference type="GeneID" id="28828525"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_723253"/>
    <dbReference type="InParanoid" id="A0A194WSQ4"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="668" mass="70515" checksum="F9A653B3471E704F" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTE7</accession>
    <name>A0A194WTE7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_739864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28830244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_739864"/>
    <dbReference type="InParanoid" id="A0A194WTE7"/>
    <dbReference type="OrthoDB" id="3644718at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22019" checksum="1EDBD4548DC40EEC" modified="2016-10-05" version="1">MGNSTSKTAPRDETRLQLGNVSAGIAGGTGKSGDGHWGSDGKVERVVQTGQLLDLPTEIHLHIFENASPITRRLLGATCLAFYRIYKQDYYETEIVINVLDIFHDPLSQTWAPLIGTLEYRRILSNWAIAPKIGPLMPGCNQLLIETEVDQYAYKVKQLLAKRHHNYRFADERGVTRVVTPTLDFVSLAGGSAIIEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUJ4</accession>
    <name>A0A194WUJ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_228558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018206018.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A194WUJ4"/>
    <dbReference type="GeneID" id="28815744"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_228558"/>
    <dbReference type="InParanoid" id="A0A194WUJ4"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="74"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="55887" checksum="5AA2C1F72A5BAEE5" modified="2016-10-05" version="1">MRTKTMLSIDEEKVMGQEELVDIEANTRTHLGIIFTPTSDHSSQSFPPQKEEATVLHKFLRYPAPGSLTIKSTSWLDGVRGVAALGVYMFHAMGCWARIVPAWHADADQNNILQLPILRTFFVSGGAAVSLFFVISGYVLTHRSLRWMRAGSAHRVPPAVASSMFRRGFRLYLPPVLLTFCEMLSTRCGFVPGYNFTFVPESSFFAQFVDWISETYHLISPIYNFKRAMQGFITHPKYDAVVWTIPLEFYGSFVCYILLLILVWIPNDGARMGLVALLSISSMSMGSWNIFCFLSGMLIADFNLSQEENGTVSSTMPRIRGIAWTAVFATAFYVAGFPTLMVGEAHLKPMPGFEILRSLTPTALYMQDHSRFWWSISGVALLLSISQLPRLRSIFETYFCQYLGKISFSLYLVHLFSLVLFGLKFQEFLMRVAGLQPHANTLLYWAVCGVWYFVFTLLVFAVAGQVERWVDVPSVRFAKWLEAKCLSMCRDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUV1</accession>
    <name>A0A194WUV1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_786602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066085.1">
        <property type="nucleotide sequence ID" value="XM_018223000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUV1"/>
    <dbReference type="FunCoup" id="A0A194WUV1">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WUV1"/>
    <dbReference type="GeneID" id="28832726"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786602"/>
    <dbReference type="InParanoid" id="A0A194WUV1"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="631"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="862"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="969" mass="108563" checksum="8B9B7CDB0658A853" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW57</accession>
    <name>A0A194WW57_MOLSC</name>
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        <submittedName>
            <fullName evidence="2">DUF654-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">LY89DRAFT_688655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066558.1">
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    </dbReference>
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    <dbReference type="GeneID" id="28825474"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688655"/>
    <dbReference type="InParanoid" id="A0A194WW57"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:rescue of stalled ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
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        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="725" mass="81626" checksum="D23F98F2CB11B8F1" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0H9</accession>
    <name>A0A194X0H9_MOLSC</name>
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        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">LY89DRAFT_650626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_650626"/>
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    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="315"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="414" mass="45437" checksum="5DC8533E500F647B" modified="2016-10-05" version="1">MGSFWSLLMPSNAPQDNGFKVLIIGAGIVGLTVAQGRRENGIPFEIFERDVKGSRAQGWALTLHWCLNAFERTLGSKIAASIPTAVVDSSLKEDAGNFLFLNCATCEPRYRIPPSKRRLRLHRQKLRDVISSGLDIQEGKRLKAIEELPQGGVKAHFTDGTSSTGSMIVGADGNNSAVRKYLLPKSFKLNHLPVNLVGVVRHFTPEQAAPIRALDPLLFQGLHPDTGNYLWYSIQECIDEPDGRKSFDALVIISWFIKDEVKDAIPATHAERIALMKQRAEGYAEPLRSIVIDIPDDLPFTTPLRLADFPSVPWDNRNGQVTLAGDSGHAMTMYRGEGANHGILDAALLVDQLKKIHEGSVSLKTAIDAYEIEMRPRTHAAVLKSRQAALDAHDWDALTEDSPTIGARSPPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0Q2</accession>
    <name>A0A194X0Q2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_785143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947422">
        <property type="protein sequence ID" value="KUJ13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067797.1">
        <property type="nucleotide sequence ID" value="XM_018222859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0Q2"/>
    <dbReference type="GeneID" id="28832585"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_785143"/>
    <dbReference type="InParanoid" id="A0A194X0Q2"/>
    <dbReference type="OrthoDB" id="9970537at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13591" checksum="B58164A244665BE3" modified="2016-10-05" version="1">MEQFEFHPAATHPGRTWLEKASLGSKIEEMILNEDPTNGRRTLLQRHEPGSLDAKESLHDYIEEIFIVEGDLGDKRTGLIYEKGYYAYRKPGMVHGPFFSEKGCLMFITCTPVEEGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1G6</accession>
    <name>A0A194X1G6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_736696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068047.1">
        <property type="nucleotide sequence ID" value="XM_018220164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1G6"/>
    <dbReference type="GeneID" id="28829890"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736696"/>
    <dbReference type="InParanoid" id="A0A194X1G6"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="166" mass="18940" checksum="7BA1E0E33776E594" modified="2016-10-05" version="1">MECLRRVFRVLSLSHDYPDPVKLNHELPRLNALEFSLLEKLPSELVVQIISYLPPESASMFAISCRPFYYMPRKQVLEPLQYGNGITMVVDHQRMIIEISSIKGATPAARIHGTTLSLLLKDFPFSTVCHLCGKLHSLASPEPICPSPQYPRPWRQCLVLDEIRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X1V6</accession>
    <name>A0A194X1V6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase substrate binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_698602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068526.1">
        <property type="nucleotide sequence ID" value="XM_018216994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X1V6"/>
    <dbReference type="STRING" id="149040.A0A194X1V6"/>
    <dbReference type="GeneID" id="28826720"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_698602"/>
    <dbReference type="InParanoid" id="A0A194X1V6"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="330" mass="36311" checksum="BF011B3604365FC7" modified="2016-10-05" version="1">MSQSISQPQTTPDLTLSSLDSSPPIASTAHLSHVSYLFGYPIAHSLSPLLHNTIYKHLNLSYAYHLYETRSLASCLALTHSPKFFGAAVTMPHKVAIIPYLDVLTPEGEAIGAINTIFLRNSPDGRRLLCGTNTDCIGIREAILQNVSKEAAKEMEGKPGMVIGGGGTSRAAVYALKHFLGCGEIYLVNRDKREVDQVIAECESKGFGEGLRFVGSVEEAKKLQAPRLVISAIPDFEPKTEEEIMTRRVIETMLGKEEKGEILEMCYHPSPDSAIARISQRSGWQVIGGVEAMIWQGLEQDKIWLRRRISTLPVEKVKEVIAAKLSKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X293</accession>
    <name>A0A194X293_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_699014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068307.1">
        <property type="nucleotide sequence ID" value="XM_018217023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X293"/>
    <dbReference type="GeneID" id="28826749"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_699014"/>
    <dbReference type="InParanoid" id="A0A194X293"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ13952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="485" mass="53087" checksum="3B7F4CFC03FEBD66" modified="2016-10-05" version="1">MGKATTIVSAVFLAIGGFLFGYDSGIITSTIAQPRFITYFNHPSDSLQGGIVSSLQGGAIAGTIVTFVVADALGRKRTIALGSAFATLGCALQAGAASMAMLIVGRFIAGMAVGILTSTIPMYAGEISQASFRGILSGLLQWMLSWGFLVAQWLGYGCTFVDTDFQWRFPLAFQCIPALILLCGVWFLQESPRWLMEKDRHEEALAVLHKLHDDGTEATKEYVELEFREIRDVIIADRSTNQISWSSIFRKPSWRRRLLLGCGVQAFGPLSGINVINYYGPHIYELLGIGTQESLMIIGISGALSIVYCTIGLWSLDRIGRVKPLILSAGGCALALVVNAALSQHLTGAGPNQLRAMVAMNFVFSLFYTPTGIISWVYPAEIFPVDIRAKGNSISTFVNWTLNLVFAQISPNALSAIGFKYFYAFFCFGVIAVVCYSLFYPETKGKTLEQMDELFGDHLHYLLLFRVLEAPALMELPMQMKGDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X2R3</accession>
    <name>A0A194X2R3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_736505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068826.1">
        <property type="nucleotide sequence ID" value="XM_018220127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X2R3"/>
    <dbReference type="GeneID" id="28829853"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_736505"/>
    <dbReference type="InParanoid" id="A0A194X2R3"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
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            <end position="337"/>
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            <begin position="455"/>
            <end position="465"/>
        </location>
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        <source>
            <dbReference type="EMBL" id="KUJ14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="465" mass="52951" checksum="BFF18B1F79CDD048" modified="2016-10-05" version="1">MPDFNDFVLDASWDAASPPPLQTWTRAPQGQNIMIGEGSGQNSSPFSMTAQVFTRKCSEIGFSQPFLDKLISRAPLFEYRFVFPGPTDPTATAVSPTHLEVAMANFENDSFFCLFRYGLIDRRSHCLLFLKTGDYLKKDLLKATDFIPWLDNNQEVLQRHPMLILNVILAFIQGREYEFVEWRMDLYDMESRLGVTRDGTYLNSSGYASIDHDFRLLNADIAGFVKKVADTELSASTVLEHAKSVQRLMGICEDLQSSPNNQLRILSEQREELQATIIRAELYLKHMKMARDVLQSLTAVLYNRISKQDTDSMKTIAVVTLVFLPATFISAIFSTGIFNFHATESPDNPRTVSKYGWVYLIACLLSTALTLISWSCWYRWGRVWLEKLNFSRIHSHGTRKSSNSGKRQLWRRGIAALPRLRRAPNRRVNTDVENPLRNPDPPEELHNMTIPNIGVSPQQSGNENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3H2</accession>
    <name>A0A194X3H2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_136989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="28815008"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_136989"/>
    <dbReference type="InParanoid" id="A0A194X3H2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="76" mass="8805" checksum="910E5CDF66F801D1" modified="2016-10-05" version="1">MVGTLSHDPSTVIWNFTLIHPSVLPQISKRALTARFLDPDLNLRPRPKNSVQLTLSQIYKKENQTQFVSSFVQRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X557</accession>
    <name>A0A194X557_MOLSC</name>
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        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_686083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="28824932"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="527" mass="57879" checksum="A41CC27A8192E571" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X634</accession>
    <name>A0A194X634_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_90467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069996.1">
        <property type="nucleotide sequence ID" value="XM_018223510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X634"/>
    <dbReference type="FunCoup" id="A0A194X634">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X634"/>
    <dbReference type="GeneID" id="28833236"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_90467"/>
    <dbReference type="InParanoid" id="A0A194X634"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ15641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="126" mass="14068" checksum="E71FD0EC0F751E55" modified="2016-10-05" version="1">MSSQPLLQTAPGKRIALPTRVEPKVFFANERTFLSWLNFSVIIGALSVGMLNFSDKIGYISACVFGLVAIFCGAYALYTYHWRAKSIRQRGQAGFDDKFGPTFLAVCLLGAIIFNFIIRGVMLYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X8I5</accession>
    <name>A0A194X8I5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_734521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070779.1">
        <property type="nucleotide sequence ID" value="XM_018219917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X8I5"/>
    <dbReference type="GeneID" id="28829643"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734521"/>
    <dbReference type="InParanoid" id="A0A194X8I5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17308" checksum="03ECD5AC6175C131" modified="2016-10-05" version="1">MDPTSPKRQAKRTHVPGIAIEGHYGMMVNPRGANARDSAYAYTTSPPPNHVPPKPEPEPRKNLTYMSLTGISGVAEKMTASPSPLRIVGANGPSLSFGELYKGIAKERKIEEKDVGDLITVRESQMRELVREHNEMRERCKELERMLERAQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X909</accession>
    <name>A0A194X909_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070627.1">
        <property type="nucleotide sequence ID" value="XM_018213127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X909"/>
    <dbReference type="GeneID" id="28822853"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669805"/>
    <dbReference type="InParanoid" id="A0A194X909"/>
    <dbReference type="OrthoDB" id="3545182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="762" mass="84799" checksum="35E30A2D6DEB7AA6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X952</accession>
    <name>A0A194X952_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071061.1">
        <property type="nucleotide sequence ID" value="XM_018213072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X952"/>
    <dbReference type="GeneID" id="28822798"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669173"/>
    <dbReference type="InParanoid" id="A0A194X952"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="49189" checksum="F1B3D67193397AE1" modified="2016-10-05" version="1">MSNAVLPTRRRSNSRSYWQNAKPTPSINATQNVQPHPSILGLALFIDAVALTLPTVLVASIILEMTTTVLVTLLAGFVLNTLPVLETLPNTAPTDLAGTTEVKLSARAKTLFLFEGDTGATAFVTVGRREVDDIERDEVEEVRLVLVTFEDNAEAESHESFEEDEEELEMNWAAWVDLVLDTDDDGERLGLLELKTGTVELVCMVPVDVSFMLELVDVDFRLVLGTLLVNLVELTRDICREVDANVAAVPLDKTSSGVDNKSCALKPKLNIDVEDRSRLMLELVPRTITEVKSEGSTGNTDEDVRVGATPRVELNNRSGKTLELVTDKLRDVVLDSRNCGVDDEVREEAAPRMEIDTKLLDDDDNIEAGTAAVVKLENVEIGVDVPLGTELNSDKTGLNVEVVATWLVTEIDVDINSTVVIVAAATRLLLFDISSDAELEAAVVELALGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9I3</accession>
    <name>A0A194X9I3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_684868</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071190.1">
        <property type="nucleotide sequence ID" value="XM_018214975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9I3"/>
    <dbReference type="FunCoup" id="A0A194X9I3">
        <property type="interactions" value="1064"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9I3"/>
    <dbReference type="GeneID" id="28824701"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684868"/>
    <dbReference type="InParanoid" id="A0A194X9I3"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="412"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="772" mass="88935" checksum="6D0382467D529406" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9S3</accession>
    <name>A0A194X9S3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_782161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071273.1">
        <property type="nucleotide sequence ID" value="XM_018222553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9S3"/>
    <dbReference type="STRING" id="149040.A0A194X9S3"/>
    <dbReference type="GeneID" id="28832279"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_782161"/>
    <dbReference type="InParanoid" id="A0A194X9S3"/>
    <dbReference type="OrthoDB" id="5279415at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="484" mass="55108" checksum="1CB2F9B94D612307" modified="2016-10-05" version="1">MADTHNHVPDHICMMEGPDPELSISTSQFDDLRDDLRRADDEISRLQALLRENNIDYRRVHRPSQSESLDNSQDSELEVGEKLPDLPQEIMFQILGYSLTSSTTLTDPFYKGRKSNMTPEEQFARKKINVNFLATSKVFRDEGKALILKNNDIVFTQVAALANFAKIPAALRVKIDHVTLRVVGRYYGDKAKKEFNMQEESRYHALVPKFKIPLLARPKGMIKEHGIHAYCYMQVGDFLKALFVPRRISNGRQYKLLPSLKTMRMDLINFSDHLVLGRTYFTPIIRWHLNKFLDELLVTGGSLGGEEDEEMYVLRNLVSNGGLFSENGAVFISVPGGLKPLPPYGITHELVRSEEVPMKSFQKYHPEGGTPPKSHPERKTVFKWAADSLSERKRWIEFDYLTGEELTPDWNDIESEIDSEDMYDESEDEGDGSDFDHGSYDSSSSNHLLGTDDFYAGSDDGFESAVETLEPIFKSQVVVDETTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9Z2</accession>
    <name>A0A194X9Z2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_707355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071309.1">
        <property type="nucleotide sequence ID" value="XM_018217601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9Z2"/>
    <dbReference type="STRING" id="149040.A0A194X9Z2"/>
    <dbReference type="GeneID" id="28827327"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_707355"/>
    <dbReference type="InParanoid" id="A0A194X9Z2"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="49233" checksum="AA837670A002FEAF" modified="2016-10-05" version="1">MAEAMHQCQNWAAQALDRSIQTISSHPRYVLYGISAVCLAAWLLISATRYLKQSTNTRPATPDLEKPASRSLKAPSRAPGVWEPMKFDRPAAVPALNWNVYTSKPKPYRPFRHGPYHITMGLRNMDWNEWIELDNHYLKFHADKAKRIIERGPNCSHTDPSAFDGAVELLEEFCSYLPERYPTLYKRTPVGMDNIVTGETFNIVERPLIEDPMQMAARMVQDDLAIMFEKADGQYYLLAGSILLAGFWKLEDKLGMPLSEIHTHGDVPGYKEKLEKGMMNFFRRVQPNGPVQRNNYFIQVDDELAWSSSIGSEDGPEGTVGWFTAEKNKAIEHHYFRSERQSLRRLSRSGGVVFTIRTYFHPITEICEEPYVPGRLASAVRSWGDDVSKYKGKERYQDVLLEYLDAKHKEQVEAGLEVDKEEEVRAYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XA88</accession>
    <name>A0A194XA88_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_718461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071032.1">
        <property type="nucleotide sequence ID" value="XM_018218418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XA88"/>
    <dbReference type="GeneID" id="28828144"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_718461"/>
    <dbReference type="InParanoid" id="A0A194XA88"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="92" mass="9879" checksum="E266EC6AC4565C56" modified="2016-10-05" version="1" fragment="single">MLLAFPRPRISVGRFTQVALVMFVSCSVFFGFRHLAAQTSFGSDILASFDLSSSSKDGNATLLALAPSYINAIMNPNDESFSQAECPKLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAC3</accession>
    <name>A0A194XAC3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_669181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071072.1">
        <property type="nucleotide sequence ID" value="XM_018213074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAC3"/>
    <dbReference type="GeneID" id="28822800"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_669181"/>
    <dbReference type="InParanoid" id="A0A194XAC3"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="216" mass="23870" checksum="A41FBEF3FD54314F" modified="2016-10-05" version="1">MSSLSYSSRDTSTFSQTASSTSASSTSNSASEVSTTLFPSEFGFYRFSSSSTVALTTKDPSPFASIQSNSGFRSKPDLTFYQGRNKWYRQLASAQFVGPEGKPHITLGSTRYGAAPTEKVECEGFFRVSHHFSLYLNSVRYREHFQWSECSHAELKGFGIGHSSGMKLVRMKTGEVVVVYAKVSCAVKKIGKMRFLEVELGNEFQVMAVMSLIAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAI4</accession>
    <name>A0A194XAI4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_73285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071535.1">
        <property type="nucleotide sequence ID" value="XM_018219739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAI4"/>
    <dbReference type="GeneID" id="28829465"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_73285"/>
    <dbReference type="InParanoid" id="A0A194XAI4"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="242"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="438" mass="50820" checksum="327E53B495876705" modified="2016-10-05" version="1">MIPREIVAQLIAERGDLNPAPRGIQEVITACCFLSILLPAGVVRLSAGPIIFGLYFYILFWTEQQSRQSYLLGVSCTILVYRWLDLVVIHKPERDFWKVEEQDDGTVVQGRAPEGWWPRLKWAFFLWNNQRGVGWNIEPDCLPAAVPRGYSRSQFLKDTFRRFGYALLSQALTNAVLRIGYFYFLSQYPWDDQSYHFFRFPLTGQIMLSWVTAFKLYTNINMLYFALALVTVLLNIYEPRDWPPIFGSFLFDGWSVRNMWGRCWHQMMRRPCSEAGRIVKNIFGFRKGGFMSRYSQIWVGFAVSALAHQAGAKVGMYQDGGYWQAVYFMTQPLAIMFEDGIMALGRRAGVKSSGWTKFIGRAWVFLWFSWTLRFMVAYQPTSWLIDESVIPWNSATIAAADKIDPDLAVLLTAEHWKLRWLCNALGIECGYYSDKVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAJ0</accession>
    <name>A0A194XAJ0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_585563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071132.1">
        <property type="nucleotide sequence ID" value="XM_018209327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAJ0"/>
    <dbReference type="GeneID" id="28819053"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585563"/>
    <dbReference type="InParanoid" id="A0A194XAJ0"/>
    <dbReference type="OrthoDB" id="3508416at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="206" mass="23893" checksum="2AC1F022FB47739A" modified="2016-10-05" version="1" fragment="single">FNVSRMVREERAGIVRSPTENRRYLSNSHSRAAARTIEDLHPSLNCVLFWKDLPGDITEKEIIDQIDTGAVFSVHIRPGVPPLHPFPAANIAFMRHDGATAFLSKVRDNSLWLRGAQIDSANVTWNQHGQLDYENQDRSRVIEIKGPKKFMNWPVWDDFMKSCTKYQLCYHRFRPCPDDDYQRILEVAFARVDAQAEAIYYAIRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAL2</accession>
    <name>A0A194XAL2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_734190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071563.1">
        <property type="nucleotide sequence ID" value="XM_018219889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAL2"/>
    <dbReference type="GeneID" id="28829615"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_734190"/>
    <dbReference type="InParanoid" id="A0A194XAL2"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="194"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="709" mass="81694" checksum="4B43719C3DB18132" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAS3</accession>
    <name>A0A194XAS3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_50069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071631.1">
        <property type="nucleotide sequence ID" value="XM_018207959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAS3"/>
    <dbReference type="STRING" id="149040.A0A194XAS3"/>
    <dbReference type="GeneID" id="28817685"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_50069"/>
    <dbReference type="InParanoid" id="A0A194XAS3"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268013" evidence="3">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="356" mass="40246" checksum="1F3CCA3DA8DA5E35" modified="2016-10-05" version="1">MHFSQVFSSVLLLLTSAIAAPIEERNTCTTLAVRKEWRTLSKAERLEYVGAVKCLMAKPAQTGAFFAGAKTRYDDFLALHINSTDYVHFNGPFLPWHRWLLHLWETELRTTCGYKGYQPWWDLLQDNTIGGYAKSPLFDNTYGLGGNGPYIADVSSNITFPVQTPTVIPGRTGGGCVEVGPFANMTINMGMGLDLSYNPHCMRRDFSPTLVAEAFSNAYYEAALASENFQELNQNIQGYSFEISGMRLHAALHIGVGGQVGDEADMWSSPGDPIFWFIHASLDRLWNNWQRECWETRQSEIMGPDTIFAYPFDFFGEIPYTNITLDYELEYEHFGSNVRIGDIMDVEAPNLCYTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XAS7</accession>
    <name>A0A194XAS7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_684369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071636.1">
        <property type="nucleotide sequence ID" value="XM_018214866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XAS7"/>
    <dbReference type="FunCoup" id="A0A194XAS7">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XAS7"/>
    <dbReference type="GeneID" id="28824592"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684369"/>
    <dbReference type="InParanoid" id="A0A194XAS7"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ17281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="704" mass="79892" checksum="08DD7E350B559DE3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XB96</accession>
    <name>A0A194XB96_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_684488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071793.1">
        <property type="nucleotide sequence ID" value="XM_018214894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XB96"/>
    <dbReference type="GeneID" id="28824620"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_684488"/>
    <dbReference type="InParanoid" id="A0A194XB96"/>
    <dbReference type="OrthoDB" id="5271370at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ17438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13214" checksum="9B0029F04061A8B9" modified="2016-10-05" version="1">MIVNARGKASYRWLLTDAERKHIAALLDIQVGDLAIRGTTMNRERQICKVCGKASGLDDIVKDSLDSGTHTKEYVINALRLGPKHETTSLYDIYCSDCGEKHVYKAGWAVYDFSWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBK3</accession>
    <name>A0A194XBK3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_541730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ17142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071497.1">
        <property type="nucleotide sequence ID" value="XM_018208185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBK3"/>
    <dbReference type="GeneID" id="28817911"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541730"/>
    <dbReference type="InParanoid" id="A0A194XBK3"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23432" checksum="47E551CEBFA186F0" modified="2016-10-05" version="1" fragment="single">MLIKHSRSKKPVAIMDPDCAICSQPALAQCECEAKGLDIAVRQAEQRMMTSVFNDIRAWVRGHAQDYILSYFSMLTTRRKDHHAQTIHRITERAAYYYRARPHPTEIAAADAELKRGIDEDWKASVQRYPEVLEYFYGLVDLNLPGDEEPGVRDPPLSALGGVAVGRERERKVRLREPSEVEERRRRRRSRGAEDRDRDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBR5</accession>
    <name>A0A194XBR5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_615795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071958.1">
        <property type="nucleotide sequence ID" value="XM_018210738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBR5"/>
    <dbReference type="GeneID" id="28820464"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_615795"/>
    <dbReference type="InParanoid" id="A0A194XBR5"/>
    <dbReference type="OrthoDB" id="5229624at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="332" mass="36025" checksum="59F7ECE572310630" modified="2016-10-05" version="1">MPAMSNNHQSTPRMSSSDTSNSNCSSSRQCMTNMVTKILDSMVAHNPDTLPLAMIYRATENSHPAALGMMTSWRTITKAGPPSLLAIDTTNGTAYFALDISEGNDAIQNVLRGRVKVVGQNITELELFINRFRGDHGFSFSSQELPSNYKDLMNPPANRTKPSRADLEAISAALFANSSNPASNTSVTVADDCQFTELGWRVIDTGNYGNASSSPLDCTWPTDHPTDPNARINLVIDEEMGFVITSGVVPGKVFPYANITESAFIPDTLTAAQEAQQAWMDQMIELGTIPMLEPTGATGDTLELLQLYNDELQAMQINVYLSGPGMTSPWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XBZ4</accession>
    <name>A0A194XBZ4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_781844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072048.1">
        <property type="nucleotide sequence ID" value="XM_018222518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XBZ4"/>
    <dbReference type="GeneID" id="28832244"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781844"/>
    <dbReference type="InParanoid" id="A0A194XBZ4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ17693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="534" mass="58335" checksum="4AAEBD905B5119D8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD16</accession>
    <name>A0A194XD16_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_733482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947414">
        <property type="protein sequence ID" value="KUJ17647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072002.1">
        <property type="nucleotide sequence ID" value="XM_018219804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD16"/>
    <dbReference type="GeneID" id="28829530"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733482"/>
    <dbReference type="InParanoid" id="A0A194XD16"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="46"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ17647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="367" mass="41452" checksum="D67B130736BE4578" modified="2016-10-05" version="1">MALDITPAVLAYVPPDPPLEQFEPARDRAFFADPTKASLLSQASSIEALTPYIGTELKGVQVSQLTDAQKDELALLVAERGVVFFRDQDITLEQQHALAAHYGKQDRDPSQQDPRHVTILGHDFNIRAKDRNVAAYHGDHSFEVNPPSYTLLRMLRTPETGGDTIFTSQVALFDKLSPTFQKAFEGFFGIHSSEKYYLNSINGGGKPRRAPIITEHPLVRTHPVTHLKSLNYNPLFVTGVKGLNDRESFHTLNFLYDHLHSADDLTVRWKWTPDSIAFWDNRVVVHRAVPGGYEPSSREGKRTAIFGERPFFDPSISESWSERKERLKKEKLSIESNSEYAVKTNGHLENGTRLDEPELNFSKLNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XD27</accession>
    <name>A0A194XD27_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_696500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072435.1">
        <property type="nucleotide sequence ID" value="XM_018216843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD27"/>
    <dbReference type="GeneID" id="28826569"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_696500"/>
    <dbReference type="InParanoid" id="A0A194XD27"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="566" mass="62828" checksum="0F466568107DEF59" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XE03</accession>
    <name>A0A194XE03_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_48305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072770.1">
        <property type="nucleotide sequence ID" value="XM_018207841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XE03"/>
    <dbReference type="STRING" id="149040.A0A194XE03"/>
    <dbReference type="GeneID" id="28817567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_48305"/>
    <dbReference type="InParanoid" id="A0A194XE03"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="56397" checksum="4A87164BABF8853F" modified="2016-10-05" version="1">MTTKTGIIGGGVSGLRCADVLLQQGFQVTILEARDRLGGRMHQDTLPNGHIVDMGPNWIHGTDNNPILDLAKMTKTATHSWADEADALYDDQGKRVSNASELSGTFWGIIMEAFKFSEHHGATIDPSRSLWDFFLEKASLMSKNDEEKRKANMLLQIAEMWGAFIGTPISRQSLKFFWLEECIDGENLFCAGTYQNILAVITKHAKEQAIIHLNTKVNRIETENGQPILHTTNGGSFEFDEVVVTAPLGWLKKNKSVFNPELPSRLTEAIDAIGYGNLEKVYVTFPRAFWQGPSDEPNKEPPAGFIQWLHPAYSKPPASKDWNQEAVDLATLPGASAHPTLLFYIFGDQGSLIAKKWNDLHTESQRTTWLADYFQPYISKLPHYDAASKDCIPSYCLATSWTTDDLAGNGSYSNFPVGLKEGDKDIEIMREGLPDRNLWFAGEHTAPFVALGTVTGAYWSGEMVAQRIARKYGKECEVLDSQNVGGSSTGHDGGKDVNVRGFADDGLKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XER1</accession>
    <name>A0A194XER1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_501319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073018.1">
        <property type="nucleotide sequence ID" value="XM_018207967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XER1"/>
    <dbReference type="GeneID" id="28817693"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_501319"/>
    <dbReference type="InParanoid" id="A0A194XER1"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ18663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="165" mass="18133" checksum="1017C3069F0AD6FF" modified="2016-10-05" version="1">MQLGMQLNCTQTLYPIECLRADCSQSCVIPPVESGTAPFLAGLDLLGEESIVDIVALCSGPCCSVKNELEFVMAVGQVADNTCWHIKGSYIRSRRRGRVTVQTAMKLLMKHSDVVGVSELVSLQGSRQMIGVSRNRAALFRVSWNFNSPRSQSHLFLIVVRDVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGU2</accession>
    <name>A0A194XGU2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_642377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073704.1">
        <property type="nucleotide sequence ID" value="XM_018211746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGU2"/>
    <dbReference type="GeneID" id="28821472"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642377"/>
    <dbReference type="InParanoid" id="A0A194XGU2"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="419" mass="46165" checksum="01065BCC600FAA48" modified="2016-10-05" version="1">MSNKFQVHVLIIGAGIGGLAAAIGIARAGYQVTVIEKSSQLGEKGAGIQVPPNSSHILSRWGLLKTLSAEAMQPGSIIIRSYHDDSILSKLKLKGRDSIEEAYDYPWLHIHRETLHKALSDEATQHGVVFRLGSTVAGIDFQNSTVRIQDQKIISADIIIGADGVNSVCREALLGRPDPPVLTGDMVYRISLSTTEMKKHVELEALATKPNFNYWAGPGEHAVGYLIEHGTQFNIVIAAKDNLPFSFSRGKGDVNEMRERFEGWSSTFTLLLELASESTVWRLCCGREMETWTHGGGSFSLLGDACHSMLPYLAQGAAQAVEDGAVLGALFSRCESREDVFDVLGVYEELRMPRANMVARVSREKVGMRWRDSGEGSLNPWANLNFQKELFGYDVEGEVDNTWNRYKAATAEMRKSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHM5</accession>
    <name>A0A194XHM5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_682536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073991.1">
        <property type="nucleotide sequence ID" value="XM_018214528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHM5"/>
    <dbReference type="GeneID" id="28824254"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682536"/>
    <dbReference type="InParanoid" id="A0A194XHM5"/>
    <dbReference type="OrthoDB" id="10506936at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="75" mass="8258" checksum="E914EEE2B771A77D" modified="2016-10-05" version="1">MATSTFHNATTGLFNATNTTVDLNNTCTNSTTWDSFCIEPGFIAAITLIVVPLWLGSLVFAIRCSQVRWITKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHU5</accession>
    <name>A0A194XHU5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_461305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074145.1">
        <property type="nucleotide sequence ID" value="XM_018207685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHU5"/>
    <dbReference type="GeneID" id="28817411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_461305"/>
    <dbReference type="InParanoid" id="A0A194XHU5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="137" mass="15410" checksum="B2012855FB2A1415" modified="2016-10-05" version="1">MEPCRPRRRRTAILIAVVSRYADEARAKKNRGRTSSALVLRRVVFNCAIFQEQSSLLEYGVAVALAGLKLLQKFWLTLILAAARSASSYVLGTEIEYAYIYSETFLMVLPMVACDESVVERRSGLSSMWRAEDARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XI58</accession>
    <name>A0A194XI58_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_465325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074265.1">
        <property type="nucleotide sequence ID" value="XM_018207711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XI58"/>
    <dbReference type="GeneID" id="28817437"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_465325"/>
    <dbReference type="InParanoid" id="A0A194XI58"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="867" mass="96389" checksum="253CC9DF917E3C57" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIC6</accession>
    <name>A0A194XIC6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_464483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074234.1">
        <property type="nucleotide sequence ID" value="XM_018207706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIC6"/>
    <dbReference type="GeneID" id="28817432"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_464483"/>
    <dbReference type="InParanoid" id="A0A194XIC6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ19879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17305" checksum="0DBF2A519D6F0131" modified="2016-10-05" version="1">MRPVTSTAPVPRASNPPPIRRPLPSITLMDHLYLPSIWPVWSWRRKLGSLREGCTRLDETRLHLSQFRISPWISTSYTITDPQSSSTYPPLPHASSWSAMLNPEVGHFRHEEISLKCLPWRLEGFASYRTRCSHDARSIIKTGARPFSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIC7</accession>
    <name>A0A194XIC7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_642611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073877.1">
        <property type="nucleotide sequence ID" value="XM_018211759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIC7"/>
    <dbReference type="STRING" id="149040.A0A194XIC7"/>
    <dbReference type="GeneID" id="28821485"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_642611"/>
    <dbReference type="InParanoid" id="A0A194XIC7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="462"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="7">
        <location>
            <begin position="678"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1163" mass="128888" checksum="13E676A52A45E048" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIL2</accession>
    <name>A0A194XIL2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_641363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018211710.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28821436"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_641363"/>
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    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="259" mass="28470" checksum="84B46498DA10CFBE" modified="2016-10-05" version="1">MSAMDMFWAAPPISRTLAASAFVLSICVYTGMIPFYWVLFHYSKFMVLPPELWRIFTSFLITGKDLGIIFDTYFLYTYGSKLETASPRFTGPGDFFMYIVFVCATVLGLNIFVTGGMIFTSALVLAFAYTSTQDDRGQKATFFIVTIPAQWIPYAMLLMTFIMAGPEAAKVQATGLVAAHLHDFLTRLWPTFGGGRNLVPTPAFVKRMWQSTEASVADRAYGTAFTPAQRTSGTSTGAAGGVLPESWRNRGSGHRLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJG8</accession>
    <name>A0A194XJG8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_682032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074629.1">
        <property type="nucleotide sequence ID" value="XM_018214423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJG8"/>
    <dbReference type="FunCoup" id="A0A194XJG8">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="GeneID" id="28824149"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682032"/>
    <dbReference type="InParanoid" id="A0A194XJG8"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="271"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="490"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="575"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="843" mass="93812" checksum="0DA938F3540456B0" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJS5</accession>
    <name>A0A194XJS5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_579784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074387.1">
        <property type="nucleotide sequence ID" value="XM_018209028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJS5"/>
    <dbReference type="STRING" id="149040.A0A194XJS5"/>
    <dbReference type="GeneID" id="28818754"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579784"/>
    <dbReference type="InParanoid" id="A0A194XJS5"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="5">
        <location>
            <begin position="239"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ20032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46696" checksum="DFE4D75794547351" modified="2016-10-05" version="1">MLVVCTDVRVQRTYPGQSGINPLPMDWGNKDPQKRGPVVVSRGQTTIRRRNAIGAHGGSYSIYYALAVASKEIKVDHRPDFTNTEPAANLGPFPQWADKKKIVSMDPLGHLAPWLFSETIEKENADCQPAITRAHMKLPELEQSVREGRLVPDGKVCLNESGELAVTKFAVEPVWYLPGVAERFGIDEGSLRRSLFEHTGGSYPELITRGDIKLFLPPIGGLTVYCFGDPAKMSDEKVRLALRVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQKGGSGVVIYFRKEGRALGEVTKYLVYNARKRGLDRASEYFKRTENIAGVKDMRFQALMPDILHWLGIKKIDRMLSMSNMKHDAIVSQGIPIHERVELPESWMPEDSRVEIDAKITAGYFTTGHRMTEEELAAVKGRSWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKJ9</accession>
    <name>A0A194XKJ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_682343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074989.1">
        <property type="nucleotide sequence ID" value="XM_018214490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XKJ9"/>
    <dbReference type="GeneID" id="28824216"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682343"/>
    <dbReference type="InParanoid" id="A0A194XKJ9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="244" mass="27863" checksum="EA98E3494B47E4AA" modified="2016-10-05" version="1">MCHISSQLYGCGHMRAIITYCESCTFLSKRPSQTKIQAEAQYYKTKGLYCNFYATKWYAKLMECPNFQYKYRSGLEEDCRGRIFTLKKHWCGTSPIYQLSALEPLEQPLIENEDLTDQLADLEKASRTEVNKRNDKYFLEQKAALDKLAVDGEGMDKAYTELMEGLSKFEKMSKHKSSAECGDQPTTAENMPGEGEPAGTRERMPEEGETVDECKKSNVRMVRTSMTYSPEDVVGEVVEPMFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XKU1</accession>
    <name>A0A194XKU1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_716156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075205.1">
        <property type="nucleotide sequence ID" value="XM_018218251.1"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XKU1"/>
    <dbReference type="GeneID" id="28827977"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_716156"/>
    <dbReference type="InParanoid" id="A0A194XKU1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="19"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="971"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2491"/>
            <end position="2569"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="2571" mass="281702" checksum="73CE843A045A4002" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL74</accession>
    <name>A0A194XL74_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_638532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075236.1">
        <property type="nucleotide sequence ID" value="XM_018211582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL74"/>
    <dbReference type="GeneID" id="28821308"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_638532"/>
    <dbReference type="InParanoid" id="A0A194XL74"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ20881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="179" mass="18843" checksum="3BBA9F7463332823" modified="2016-10-05" version="1">MSANQDSVSNQGEFHSRVPPSEPLTTKGHAPGVKVGNDAAPEFHAETLPAGTAPSDRTFQPQTQSEIPGQAMNPNISKETWTSASDTIGGATSADVHTGYGHPGSGQTSNELHGVRKKEKNGLAGVGADPTNTFRERGQDIDFPKGTKGKSGTLEERQNVPGAEEREPVSSEEVAPMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL75</accession>
    <name>A0A194XL75_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_579338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074882.1">
        <property type="nucleotide sequence ID" value="XM_018208998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL75"/>
    <dbReference type="GeneID" id="28818724"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_579338"/>
    <dbReference type="InParanoid" id="A0A194XL75"/>
    <dbReference type="OrthoDB" id="3498215at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="412" mass="45285" checksum="60EC7E9C51A59390" modified="2016-10-05" version="1">MPQTSAPANKPVKHRACDECRTRKLACSKDPDGCERCRRENIVCHYSEQKPMGRPRKRQFIETTREEPTNNANIDIDVSALPLVADDLEGYNDSNVAEPYFTNTQSSYGLRPEPTSEQLMSKLDNGRTIWHFGDGDIMNGPHINFGNIDFGPPDGPLPSLDSAPQLTTSNASVSDSEQSTPQALPLGPCSCLPSMYLSLSALQTLPTDIVVALKTVRSAAATAASCIWCAQCGAIVLDNPNPPIESFQNTMLLGTILPIIANSYQKLLKMVDDETDAAEAAGETKTFRFQDYGGLCGKQKTVEHTMACLDKELMFNAVEMPAHQWRTTVRALLRVDIYGHEQDGFRHKGLKDLVGEMELRQRTRHDMLDAHVAAGNMEYGSFGQKLCLGEQTHGCLQILKMAKVAIDALVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL93</accession>
    <name>A0A194XL93_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase Ure2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_681539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075256.1">
        <property type="nucleotide sequence ID" value="XM_018214319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL93"/>
    <dbReference type="FunCoup" id="A0A194XL93">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XL93"/>
    <dbReference type="GeneID" id="28824045"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681539"/>
    <dbReference type="InParanoid" id="A0A194XL93"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="231" mass="26635" checksum="7FBF2FC3B83C30E5" modified="2016-10-05" version="1">MTATIKPLTLYGGVLGPNPAKVSLVLNTLSIPHEAVYVPYTDIKGPEYTKLNPNGRLPTLEDLNNGIKLWESGAIIEYLVEKYDPEFNLSYEPGTEEYYLCKQWLHFQMSGQGPYFGQAVWFMSLHPEKIESCIARYINEIKRVSAVLDKHLSTHQWLVGNKMTYADLSFLPWQEFAFEKVTPRFFAAKTEFPHVQRWIEEMSAVPGVKKVLDEKKVKNREIYGERADRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM27</accession>
    <name>A0A194XM27_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate 1-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_577528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075588.1">
        <property type="nucleotide sequence ID" value="XM_018208900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM27"/>
    <dbReference type="GeneID" id="28818626"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_577528"/>
    <dbReference type="InParanoid" id="A0A194XM27"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="307"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ21233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="445" mass="49299" checksum="4ADCF8F118A8D713" modified="2016-10-05" version="1">MGSLGHETTPLQVAIVGTGIAGLTAAIALRQHPNINVVLYEKATELKEIGASITLGPNGLRTLERLGLQDCITDQVAYRGPNPISRIYRHWKTNEIIGEDFYENVSEPLHYTARFHRGHLQQALLKHIPRDTIHLKKKLVSVTVHPVDGVQMTFQDGTTATTDLLIGADGIASGVRKSFAPDFKLEWSGHTAFRGIFPASLVAPIAGVPLDSTHWWGPDTNFFATRLARDLFTVQGGIYADPNDPVAIAKFRDGGRWDREADVELLREKYVDWNPVVQNLANTCPDIRYYPNYFCGSSLPTWIFGLGRVTLIGDAAHAHGGAFATGGSLAIDDAYALYLAILEVYPVTETGRRLGREGVERALRLYESTRRPHAVRLLKVVHANNEMKTRKILAETRETDEELRARAKAGSGTTWLHEHDVVKAFEEVVRAERERGKGVSEVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM30</accession>
    <name>A0A194XM30_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_771897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075177.1">
        <property type="nucleotide sequence ID" value="XM_018221897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM30"/>
    <dbReference type="GeneID" id="28831623"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_771897"/>
    <dbReference type="InParanoid" id="A0A194XM30"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268399" description="Cellulase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="11">
        <location>
            <begin position="34"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="174" mass="17564" checksum="B9A77B3C337A5074" modified="2016-10-05" version="1">MKSSTLLALLATAITPIVAISGQATTTRYYDGLEGACGCGTSSGAFSWQLGVASGVYTAAASQAIYSSSGATWCGAGCGTCYNLTSTGSSPCQDCGTGGDAGQSIIVMVTNLCPNNGNAQWCPAVGGTNEYGYSYHFDINAESEVFGDNVVVNFEEVACPSAAVSDYSQCVCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM91</accession>
    <name>A0A194XM91_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARF/SAR superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_681529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ20887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075242.1">
        <property type="nucleotide sequence ID" value="XM_018214316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM91"/>
    <dbReference type="STRING" id="149040.A0A194XM91"/>
    <dbReference type="GeneID" id="28824042"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681529"/>
    <dbReference type="InParanoid" id="A0A194XM91"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="122" mass="13898" checksum="099694752BE2CF89" modified="2016-10-05" version="1">MTIGDVGGQKTLRSYWRNYFEKTDALIWVVDATDRLRVDDCREELHGLLQEERLSGASLLVFANKTDVSGCMDEDEIQQGLQLDAIKTHKWHIIRCSAITGANLQEGLAWVIQDAKARLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPB7</accession>
    <name>A0A194XPB7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_715010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076361.1">
        <property type="nucleotide sequence ID" value="XM_018218171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPB7"/>
    <dbReference type="FunCoup" id="A0A194XPB7">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XPB7"/>
    <dbReference type="GeneID" id="28827897"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_715010"/>
    <dbReference type="InParanoid" id="A0A194XPB7"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="295" mass="33665" checksum="F44D4324EF1262B9" modified="2016-10-05" version="1">MASKGLQTFSRSLRTLRTFTPSSKDPLTQCLAPRLCRSMATETAMPSEANRMFGNSFLQTASDPIYDLPDPTVTTTVYKFPEMEPLRFESYDSKHLHLPLRRDILHRAVVFEGDATRQGTASTKTRWEVHGSHRKIRPQKGTGKARLGTRQSPMLKGGGKSFGPHPRDFSTELPRKVYDLAWRTALSWRYRRGELIICEDGMDIEYPKTRYVKDIFQHNGWGQPDGRSLVITGSFRKNLFRALRHAGEDGRIQMAREVDVKDLLELGRVIIEKKALDEMLKEHSSDLGPKFKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPP2</accession>
    <name>A0A194XPP2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_394738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076481.1">
        <property type="nucleotide sequence ID" value="XM_018207220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPP2"/>
    <dbReference type="GeneID" id="28816946"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_394738"/>
    <dbReference type="InParanoid" id="A0A194XPP2"/>
    <dbReference type="OrthoDB" id="4362523at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ22126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12543" checksum="7AE08D08219A81DC" modified="2016-10-05" version="1">MSQLEHGEQPASYSTSASLYQLRLFKLIVIAFLMSRMSTSSSSEHASSKARIEAVIPTIVNILEPFQASSASIGVMHNGKTLYTKGFGICDRDDSRIPDEKTMYHIVSCTKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPS8</accession>
    <name>A0A194XPS8_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_777397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076615.1">
        <property type="nucleotide sequence ID" value="XM_018222141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPS8"/>
    <dbReference type="GeneID" id="28831867"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777397"/>
    <dbReference type="InParanoid" id="A0A194XPS8"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="147"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ22260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="434" mass="48176" checksum="1517815575811104" modified="2016-10-05" version="1">MAPSDTPKKPFHIAVCGGGIGGLCMAIGLLHQNISCTLYESAPAFAEIGAGVSFGPNAIRAMSLIDPDIKKGYDKIATSNAWPEKRKFWFDFNLGQKSHTWGDMKAPGEEMLRVAQVVAGDIGQSSVHRARFLDVLVDLVPDGVAKFGKRVEKVDKKGKKMILTFHNGSTAEADAVIGCDGVKSRTRQILLGEDHRTTDPTFTGKYAYRGLIPMEKAVGAIGEELARNSQMYMGRHGHVLTFPIENGRTMNVVAFRTKEDGKWEDERWVLPMKKEDMFDDFAGWGDSVQQILSLMEKPDVWALFDHPPAPTYYRGCLAILGDAAHASTPHQGAGAGQAIEDAFILSNLLGQVESVNEIEKAFHAYDAIRRPRSQKVVTTSREATAIYDFEDEKLGTDLDLIKRTLETRYDWIWNEDLPQQLRRAREIAGQRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPU2</accession>
    <name>A0A194XPU2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_728436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076630.1">
        <property type="nucleotide sequence ID" value="XM_018219263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPU2"/>
    <dbReference type="STRING" id="149040.A0A194XPU2"/>
    <dbReference type="GeneID" id="28828989"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_728436"/>
    <dbReference type="InParanoid" id="A0A194XPU2"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ22275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="299" mass="31678" checksum="97055F340D34F3E0" modified="2016-10-05" version="1">MSASPPKETEHEGVQSPDDPDAQMNQDPHSSGLAYEFEVKEQDRWLPIANDILRILKLAVTGTASRTCIECSRMFLNWPVIELGAQTLQVCCVTAIICPIMSHSSSSPSPQAPSSTSKTSKGSKDDYLDSNIRNFAPVARIMKTALPENAKIAKEAKECMQECVSEFISFITSEASEKCHQEKRKTVNGEDILFAMTSLGFENYAEALKIYLSKYRETQSTRGENRPGSQGFGSAAAGGSGGAANATSSTTFAGGPEGTNNILGGQPGEGADHDGGSYGNIYGGQVSSGHNGATGGEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XR28</accession>
    <name>A0A194XR28_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_680652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076864.1">
        <property type="nucleotide sequence ID" value="XM_018214118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XR28"/>
    <dbReference type="FunCoup" id="A0A194XR28">
        <property type="interactions" value="836"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XR28"/>
    <dbReference type="GeneID" id="28823844"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_680652"/>
    <dbReference type="InParanoid" id="A0A194XR28"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ22509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="109" mass="12215" checksum="F0AF9AFB9F0E1A1D" modified="2016-10-05" version="1">MPSEAGHRLYVKGRHLSYQRGKRNTTPGTSLIQIEGVSDTKAANFYLGKKVAFVYRAQKEVRGSKIRVIWGKVTRPHGNSGVVRAQFRRNLPPKSFGASVRIMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSD7</accession>
    <name>A0A194XSD7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_165778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077411.1">
        <property type="nucleotide sequence ID" value="XM_018205525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSD7"/>
    <dbReference type="STRING" id="149040.A0A194XSD7"/>
    <dbReference type="GeneID" id="28815251"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_165778"/>
    <dbReference type="InParanoid" id="A0A194XSD7"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012985">
        <property type="entry name" value="Peptidase_S64_Ssy5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08192">
        <property type="entry name" value="Peptidase_S64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30889" checksum="B9CE18AE1995F585" modified="2016-10-05" version="1">MNMNPFRGQWDSTGSPDMLSLSPQDIKATRKYHKDTIKSLGKQIIHLKERDRSQLTLDALQKHDEKFSALKAQKKDYERHLPTLVKHNPKWSLASRAESSGWRSDPNGWQMDWGLATLIKNVTSPNRLPEWEFTKGEIALGIANVIAEEFPIVFPSSLTTISDVSLQSEELVIKYGRTTGWTLGKVNGCDSYHFDWQADTVTSRSLSIVGLNNIPFSRAGDSGSMILNRKGEAVALLFAGNLLSKESVNGLAFAVSMEATIADIKRRTPVIDMKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSV2</accession>
    <name>A0A194XSV2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinol dehydrogenase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_574077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077576.1">
        <property type="nucleotide sequence ID" value="XM_018208720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XSV2"/>
    <dbReference type="STRING" id="149040.A0A194XSV2"/>
    <dbReference type="GeneID" id="28818446"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_574077"/>
    <dbReference type="InParanoid" id="A0A194XSV2"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="33385" checksum="A8E7495E8159CB96" modified="2016-10-05" version="1">MAFFLQFLKSQLWVRLPIPSDDYSEQVIAITGANTGLGFESARHFLRLGAANVILCVRTRAKGESAADELVRSLHVSRTRIEVWEVDLASFASIEAFGEKLKSLKRLDVFVQNAGILTTKFARVEGCESHIAINVVSAAYLSVLALQVLQRSSIENGAKGRMVFVGSDLHLIAKFKEKNESGSLLKALNSEALADMNDRYKVSKLLLLYFVRDLAVKNPYNAPSVSDLKLNMPSVVIDYITPGACDTSIFRDDVHWIQQAIINVAVRLIARTAEEGSRTILSAVSPSVGRAEHGAFLMDCKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XSZ9</accession>
    <name>A0A194XSZ9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_755212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ23323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="475" mass="54205" checksum="E7645F43F012A71E" modified="2016-10-05" version="1">MSYRSLYSTPENTPLRPQIVEASTPWSEVSLEDHASHRFESPRGYRKLIRSFFRAHLRNWNRTLWLAMFLAYVGRWLSTSDGVHKHGSFPEKQSLQSATIPAKPLPALPFLPLTNTSNAAPISLLARVDDDEYIVLPNATSILMPIEGTPVDEDEWLTGNQAGNQALPPASTKKKMLEIVTDFPGSMAGRDKHKNTRTARGILGGVMGWESLLPDMFGADHATIGMDGMCLIEDCIGGRGSPFGLADVFFQSGPAGTDEYSHAWIFQEYTPDVIVMNIGNSDWDSFQSHYQEYNKTLWELSVVFEETYISMIKAIRTLAYPKYSTSIDSRYTYTARNAAVGIPIFIMRPFRGQLEQATHSVVDRLQKEGDKAIFWLDTSGWLNTEVDFQGRAEDQDFFLDEESPSKQWRLTERGNQRVAILLHMHVCRYLARDREKCAFLPPEIYQGKALDHEAIHFDEFLENERERKLKKMFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT10</accession>
    <name>A0A194XT10_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_777065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="28831829"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777065"/>
    <dbReference type="InParanoid" id="A0A194XT10"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268636" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1025"/>
        </location>
    </feature>
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        <location>
            <begin position="1141"/>
            <end position="1232"/>
        </location>
    </feature>
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        <location>
            <begin position="1340"/>
            <end position="1445"/>
        </location>
    </feature>
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        <location>
            <begin position="1110"/>
            <end position="1131"/>
        </location>
    </feature>
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        <location>
            <begin position="1295"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1467" mass="150531" checksum="DC67A14A362AFF44" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XT24</accession>
    <name>A0A194XT24_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_606300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077810.1">
        <property type="nucleotide sequence ID" value="XM_018210417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XT24"/>
    <dbReference type="GeneID" id="28820143"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606300"/>
    <dbReference type="InParanoid" id="A0A194XT24"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23324" checksum="189388EF0A09F793" modified="2016-10-05" version="1" fragment="single">MENAASAVTKLFAKDPAPSQSEVEGQEVTDTTSAPTSTSNDVDKTVDKEVAPAVEHTHVKKEHETREQTVVEKERHQDHYQTTIQPLKDSEVLPEKHDHVQETKERSINNDDGTAKAKAEADRTGFESTSEQQESESKTTEPTQEKEHVHHHLHETVQPVIEKEVIDPSVTHKRVDVKEKIQEPSVNHGVTTNSTISVDEFEKKLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTN1</accession>
    <name>A0A194XTN1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_777296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077923.1">
        <property type="nucleotide sequence ID" value="XM_018222135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTN1"/>
    <dbReference type="STRING" id="149040.A0A194XTN1"/>
    <dbReference type="GeneID" id="28831861"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777296"/>
    <dbReference type="InParanoid" id="A0A194XTN1"/>
    <dbReference type="OrthoDB" id="3436787at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="538" mass="55444" checksum="C5BAC19C4DBC021B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTY9</accession>
    <name>A0A194XTY9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077527.1">
        <property type="nucleotide sequence ID" value="XM_018219214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTY9"/>
    <dbReference type="GeneID" id="28828940"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727946"/>
    <dbReference type="InParanoid" id="A0A194XTY9"/>
    <dbReference type="OrthoDB" id="3536671at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16714" checksum="3DDB215FE3C2C5CB" modified="2016-10-05" version="1">MTTSPTSPHRPRRESRFTEGSETTFPPSSSSPGATPPTNDDHLLFTILSEMDEHERRRRRRQRGNSNSSVESFASIESPSSSKEREGRRRSVVFAREESSGSVGGSGMGGRRSLDERPREREGIKGLVKGRLRALTTGERRKDVKPYPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU20</accession>
    <name>A0A194XU20_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_777348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077991.1">
        <property type="nucleotide sequence ID" value="XM_018222140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU20"/>
    <dbReference type="STRING" id="149040.A0A194XU20"/>
    <dbReference type="GeneID" id="28831866"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_777348"/>
    <dbReference type="InParanoid" id="A0A194XU20"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="436"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ23636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="622" mass="68695" checksum="24629FE933EE2AA4" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUS9</accession>
    <name>A0A194XUS9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_693563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077817.1">
        <property type="nucleotide sequence ID" value="XM_018216644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUS9"/>
    <dbReference type="GeneID" id="28826370"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_693563"/>
    <dbReference type="InParanoid" id="A0A194XUS9"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="449" mass="52785" checksum="422AA4A5BE624016" modified="2016-10-05" version="1">MGTVFGFTASKDDELRETAWLDGLRGVAAFLVMVYHYHLDMFKFNTEAPYGAPNTQPWELWRLPYLRIIWCSGHTQVGIFFVLSGFVLSWSSLSSIREGRPEKFVQSLGSASFRRWMRLFLPCFLIGLLSLLQFYFALVELPITRRSSFSAQLLDYLWECERFSNPFHLERTNWEVLHKYNHTMWTMPVEWAGSLVVFMVLLMVSRIQSYTRRTIILAMVPIYSCLSAKWNYWLFTTGILLADYVKQAGGFKQLSDHMSRRSRLFWIFVLLVGGWLGGIPGKREWYERPGYEWTDNWIPTNWQDIEGGQRYFWCWSGIMIIWGLAHFTTLRRFFERPFCRYLGKISFMLYLTHRMIGTILGGPIRKQILNVLGTHYRAPDQPEIELVEINGFFWNIVAYLLAWACMLPLALALANWSTILVDEPCVKFTKWVDDKFVNGFVLEHERRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XV19</accession>
    <name>A0A194XV19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_776094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078234.1">
        <property type="nucleotide sequence ID" value="XM_018222009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XV19"/>
    <dbReference type="GeneID" id="28831735"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776094"/>
    <dbReference type="InParanoid" id="A0A194XV19"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="682" mass="74482" checksum="7505FED555C306F3" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVJ1</accession>
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        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_604932</name>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078700.1">
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    <dbReference type="AlphaFoldDB" id="A0A194XVJ1"/>
    <dbReference type="STRING" id="149040.A0A194XVJ1"/>
    <dbReference type="GeneID" id="28820099"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604932"/>
    <dbReference type="InParanoid" id="A0A194XVJ1"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="262"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="516" mass="58595" checksum="875A39057B3BF9A5" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVM7</accession>
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        <recommendedName>
            <fullName evidence="7">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">LY89DRAFT_679084</name>
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        <name type="synonym">Phialocephala scopiformis</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KUJ23762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078117.1">
        <property type="nucleotide sequence ID" value="XM_018213803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVM7"/>
    <dbReference type="STRING" id="149040.A0A194XVM7"/>
    <dbReference type="GeneID" id="28823529"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679084"/>
    <dbReference type="InParanoid" id="A0A194XVM7"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="257"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="197"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="257"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ23762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="809" mass="91023" checksum="FFEFDC7E01BB4076" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVP9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_2996</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078142.1">
        <property type="nucleotide sequence ID" value="XM_018206563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVP9"/>
    <dbReference type="GeneID" id="28816289"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_2996"/>
    <dbReference type="InParanoid" id="A0A194XVP9"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="273" mass="30615" checksum="AE985C1F12295002" modified="2016-10-05" version="1">MAPIRRYLRITKYSVLECRIYLDNPALAESWLLNSRNPILPHVIESVRPLVLPKLREENERSKKSGKKKGVKDVVVEEDFEVSIFLTETSTRHSLLSKQKHFRDKGKKTLQSNSSKLTGDTNDTAIEVEDAPIIRREDSDEDEPNLEDLPAAEDEGSDSDGLFVDEDAGQRRSKRPRATTNDSTSTVSLGSEPSTKRRRDGQEEISAEDGDDKKKMAMDTTYDGFAIYGRVLCLVVKRKDKKGKGPASLGNGQATMENWITSTQMPPQDDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XXE5</accession>
    <name>A0A194XXE5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase class C and other penicillin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_745349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078817.1">
        <property type="nucleotide sequence ID" value="XM_018221060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XXE5"/>
    <dbReference type="GeneID" id="28830786"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_745349"/>
    <dbReference type="InParanoid" id="A0A194XXE5"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="27"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ24462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="404" mass="44384" checksum="1DE5740E28D6A931" modified="2016-10-05" version="1">MEAFERALASGTAKDGRAARVSHGIIVAAVDKSGEYIYKNASGLVSLHPDSPPVQFDNELVMASCTKLITTIAALQCVERGLIGLDESIDKHLPELANSQVITYDSKSEKESFTLAPAKTQVTLRQLLNHSSGLAYDLGEPALEAWRKSRGETPLSLWAPVVPAFSTPLLFEPGTQWAYGSGIDWVGLLICRLAQRMSLENYLIDNIFAPLNMVSTTFHLWYKPEICQKFLQPAYRLPDGSLIPGILPYPHPPADEYGGNGLLSSMPDYMKVLGDIIKDSPVLLKKETVELMFSPQFEEGSGALQHLKNNQTLFENSAGGHIGNHAINFGLGALFFTQQMPLTGAPPGTLAWGGLPNMMWFANREKGVAGFYATQLIPQSDFRNTKLAALFQRSLWKMVNKQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1S9</accession>
    <name>A0A132B1S9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_726641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060691.1">
        <property type="nucleotide sequence ID" value="XM_018219071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1S9"/>
    <dbReference type="GeneID" id="28828797"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_726641"/>
    <dbReference type="InParanoid" id="A0A132B1S9"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="120" mass="13775" checksum="15D4D67459BA3169" modified="2016-05-11" version="1">MIGIVGWLFLDEVLGSSVPVLFSLLFLWVFEVQLLLQIISINRIAVVLDNRELIRRLEAVFIIWIPAHLVPPPIPLFVTINKYWDRTSKLLILLVVDASLNYFFLRTVSCTTTASPNTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3C0</accession>
    <name>A0A132B3C0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_400203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061247.1">
        <property type="nucleotide sequence ID" value="XM_018207259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3C0"/>
    <dbReference type="STRING" id="149040.A0A132B3C0"/>
    <dbReference type="GeneID" id="28816985"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_400203"/>
    <dbReference type="InParanoid" id="A0A132B3C0"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="14472" checksum="E98912D880221637" modified="2016-05-11" version="1">MEESQSSPPSCTTCHKLQADLPQPLKRCAKCQTTTYCSRDCQKQDWKLHKRVCASQAASHDGEPTPSTSTSTGGRHNPGFHAINSMMGLSSDDFLHKLPERGALTQLIDCFRMRAEDEYNFAGNTLGCYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B476</accession>
    <name>A0A132B476_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_661395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947443">
        <property type="protein sequence ID" value="KUJ06819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061174.1">
        <property type="nucleotide sequence ID" value="XM_018212600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B476"/>
    <dbReference type="STRING" id="149040.A0A132B476"/>
    <dbReference type="GeneID" id="28822326"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_661395"/>
    <dbReference type="InParanoid" id="A0A132B476"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="57"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="437" mass="48061" checksum="D01E9198D3415EA5" modified="2016-05-11" version="1">MLLDYVPPVQNEYHKFVTNQKFAYIDSIELESGEQLEGVVVAYKTWGKLNGNGDNCLVVCHALSGSSDIVDWWGPLLGNGNAYDTSRYFIFCANVLGSPYGTTSSLSLDPRSGQSYGPEFPQSTIRDDVRLHKLVLDALGVSSIAAVVGGSMGGMMTLEWPLCTPEGYLKNIIPISTSVDHDAWGIAWAEAQRQCIYADPAFEEGYYLPTPATQPAAGLAAARMVGMLTYRSSPSFNSRFGRGEGGSQLKAVNEVLANTTLVNGNGKSKRDSKSNGVHNSAKDFKAHSYLRYQGEKFVKRFDANCFIHLTQKMDHHDVTTNRIPPHELCSMSKQESLRRVFRKVPKNALVIGIDSDVLFRPEQQVEIADALPEASLVMIPSVEGHDGFLLEFEILGPLIEAHLRKQCPWIYEGAPLVVEDSTSAVRDSVFGEVESGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B477</accession>
    <name>A0A132B477_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_601929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061496.1">
        <property type="nucleotide sequence ID" value="XM_018210224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B477"/>
    <dbReference type="FunCoup" id="A0A132B477">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B477"/>
    <dbReference type="GeneID" id="28819950"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601929"/>
    <dbReference type="InParanoid" id="A0A132B477"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ07141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="300" mass="34046" checksum="8E4E04E50EA7AD63" modified="2016-05-11" version="1">MPPAKKRKTKATVDVAEEPAQVTIAEAEPASEQPEPAQKQIENELPGASSSDAATKAKERMERFKALQARAKTGAQKNLKEATLESQRLATDPNLLTSLNRKSAVASHNLLKADVEAAGGDFERKRAWDWTIEESERWDKRLKKKDAHRDDQAFQDYRQDSRKVYKRQIRDLKPDMDHYEKEKMAAVEKAAASGGLEIVEIDDGELVAVDKDGTFYSTADSTGFVEHKPPKDAVDRLVKDLQQAEEARLKKRKERMGQNGEDGDVTYINEKNKQFNQKLSRFYNKYTAEIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B489</accession>
    <name>A0A132B489_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_790009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947441">
        <property type="protein sequence ID" value="KUJ07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061590.1">
        <property type="nucleotide sequence ID" value="XM_018223322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B489"/>
    <dbReference type="GeneID" id="28833048"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_790009"/>
    <dbReference type="InParanoid" id="A0A132B489"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287843" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="70" mass="7290" checksum="69F82F610389B7CE" modified="2016-05-11" version="1">MKTSILLFLALLQVFALAAPVPSAEGLIDRTASPATLEEEGCDEAKAAAIAAGADPDLADVAYPDIYKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B530</accession>
    <name>A0A132B530_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_601706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061796.1">
        <property type="nucleotide sequence ID" value="XM_018210210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B530"/>
    <dbReference type="GeneID" id="28819936"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_601706"/>
    <dbReference type="InParanoid" id="A0A132B530"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007287845" evidence="2">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ07441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="311" mass="33742" checksum="EEFC0216E9124D40" modified="2016-05-11" version="1">MHSRLLFLLGGVARVLAQTQYTSTGTAAVAKARATALTESPTSDVVGKSFNRFVTIWCENTDYSMAAADPNFAYLATQGILLTNYLAITHPSQPNYVAAVGGSTHGISSDSFSRINSSSQTIVDLLEAGGVSWSEYQQDSPYSGFEGNYINQQTGANDYVRKHNGLMSYDSVTSNLDRLAKIKNFTMFETDLANNQLPQWMFITPNMTNDGHDTSVTVAGAWARSFLTPLLSNSNFMQNTLILLTFDETESYTSNNQVYSILLGDAIPASLVGTTNNTAFNHYSQMATVEKNWNLGNLGLGDATAASFFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6L5</accession>
    <name>A0A132B6L5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_742654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
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    <dbReference type="InParanoid" id="A0A132B6L5"/>
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    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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        <property type="term" value="F:lyase activity"/>
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    </dbReference>
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        <property type="term" value="F:polygalacturonase activity"/>
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    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
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    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="405"/>
        </location>
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            <begin position="538"/>
            <end position="596"/>
        </location>
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        <location>
            <begin position="1346"/>
            <end position="1576"/>
        </location>
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            <end position="1660"/>
        </location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF12708"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
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            <dbReference type="Pfam" id="PF05193"/>
        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        </location>
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        </location>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23288" checksum="B3FC6243588129C0" modified="2016-05-11" version="1">MLSLMLPRKSINRPKPQKQKPSVDEQQPKSRPKPLAKLFKKSSSRRASSISSSNTEASHPHTTLDSPPLPVEGVSVWNAAGQDIRTLQQRNTSTSNLSSTSTLLELPATRPALPHSPVRQSGDSYEAFLSHAQDMERRRHERDSMMAQAWLKAEERRRASRSWPSDPWRGGFGPPASDARYGGAGAFSPRRVSSGEDGVRGWLGRNGLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9G9</accession>
    <name>A0A132B9G9_MOLSC</name>
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        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="7 8">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947433">
        <property type="protein sequence ID" value="KUJ09050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063405.1">
        <property type="nucleotide sequence ID" value="XM_018217209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9G9"/>
    <dbReference type="FunCoup" id="A0A132B9G9">
        <property type="interactions" value="1086"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132B9G9"/>
    <dbReference type="GeneID" id="28826935"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_701554"/>
    <dbReference type="InParanoid" id="A0A132B9G9"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ09050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="379" mass="41306" checksum="523AE4C79ED60497" modified="2016-05-11" version="1">MYQMLQRGGMRGPPKRFDEYYRCYPTVMLPGPEREDLNYGGKIIMPASALEKLTRLHITYPMLFELINGRDERTSHCGVLEFIAEEGKIYLPHWMMQTLLLETGDLVQIKSTDLPPASLVKLQAQDVNFLEISDPKAVLEKAFRQFATVTKGDIFSFKYNDTVYDVAVLEVQPSSEKMGVSMLETDVKVDFEAPIGYVDPPKTRASSGTSTPRSMAGLPAGGVLHSQGTMAQAINYDAIAPSSNAALAGAKAVSSNFLLGGQKLSSKKGAKAPTPKPSTPVAGTSSNVPAPTVARRTNGPQPLRLPPNKLFFGYEIKPVKTQADKDKENADAAQPHFAGAGQILRDGKRKENSDKDKPAEPEKKPDPSAGRRLDGRKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B9N4</accession>
    <name>A0A132B9N4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-hydroxyacyl-CoA dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_690741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947434">
        <property type="protein sequence ID" value="KUJ08709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018063064.1">
        <property type="nucleotide sequence ID" value="XM_018216156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B9N4"/>
    <dbReference type="STRING" id="149040.A0A132B9N4"/>
    <dbReference type="GeneID" id="28825882"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_690741"/>
    <dbReference type="InParanoid" id="A0A132B9N4"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ08709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="263" mass="28285" checksum="C263B1EB05956911" modified="2016-05-11" version="1">MKIEGRTFVVSGGASGLGRACVEDICKKGGYVAILDMNEELAEELVKEIGGGKTKFFETNVLETESITAAVKGTLGWVKETGREVGGVIAAAGVSTPAKILDRNLNPFSLSDFDFVMNVNVRGTIDLVRQVLPHMARTEPADADGERGIVIMVASSAAFDGQPGQVAYSASKGAIRSLTLPMTRDLARYGIRVVTIAPSLFDSRMTAMMSDKVRASLTRVMEFPLRPGKPQEFSQLVTHSIENIMLNGVVLRLDGGMRMPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BDY4</accession>
    <name>A0A132BDY4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_740600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947430">
        <property type="protein sequence ID" value="KUJ10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064564.1">
        <property type="nucleotide sequence ID" value="XM_018220611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BDY4"/>
    <dbReference type="GeneID" id="28830337"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_740600"/>
    <dbReference type="InParanoid" id="A0A132BDY4"/>
    <dbReference type="OrthoDB" id="10483606at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="131" mass="14920" checksum="5CC39663723EC227" modified="2016-05-11" version="1">MSSVYLLQWIVIAVLLVTVLVLIKYRNSSDRQSPSVAWTSTEDKIHAEEQIQNNNVLQKANEKLARELRYLCREGGPVSSSRERLQALEACQTQLRATERVLQDTQSKLIILEHGKSVLHERQRAEGSHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132BEZ1</accession>
    <name>A0A132BEZ1_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_626709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947429">
        <property type="protein sequence ID" value="KUJ10267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064622.1">
        <property type="nucleotide sequence ID" value="XM_018211118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132BEZ1"/>
    <dbReference type="FunCoup" id="A0A132BEZ1">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A132BEZ1"/>
    <dbReference type="GeneID" id="28820844"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_626709"/>
    <dbReference type="InParanoid" id="A0A132BEZ1"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ10267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="624" mass="68916" checksum="79DEE0ACA47533BB" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WRJ4</accession>
    <name>A0A194WRJ4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_710449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018064981.1">
        <property type="nucleotide sequence ID" value="XM_018217830.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A194WRJ4">
        <property type="interactions" value="253"/>
    </dbReference>
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    <dbReference type="GeneID" id="28827556"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_710449"/>
    <dbReference type="InParanoid" id="A0A194WRJ4"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ10626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="245" mass="26974" checksum="8C563D2E032C277C" modified="2016-10-05" version="1">MAAPSTILRRLRPISARGNLLARTYHSYDHPPPPGPFSTTESTILSASLPHIPSHGFTLTSLSLGAKDAGYIDASTNLFPQGPFALVHYHLLTQRLGLAQKKEVLEADEGIGAKVKKLTWERLMGNKEIVHRWQEALALMAQPSNVPTSLKELAAQSDEIWFLSGDISVDTSWYTKRASLSTIYAATELFMTTDKSPDYIDTREFLDRRFKDVQFVGGVVGSVSQWVGFTASAGLNVLRSKGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WS56</accession>
    <name>A0A194WS56_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_251059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065156.1">
        <property type="nucleotide sequence ID" value="XM_018206193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WS56"/>
    <dbReference type="GeneID" id="28815919"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_251059"/>
    <dbReference type="InParanoid" id="A0A194WS56"/>
    <dbReference type="OrthoDB" id="3559391at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="267" mass="30873" checksum="A86ACA02BEC07478" modified="2016-10-05" version="1">MAFSVFSDEIVLLVLSYPDVLTTEDIYNVMLTCKRLYRVGIPLLYRTTQFNSPNIARPPHLSNLLRMIDLEPRRGSWVQLASVGWPGNHEKMWSKTFELVSIFHSPQSIEFHVMSWREDKDLNFARFLGECTNTSLRTVTVEDHNLRIKDIVAFYALPNLIHFRVINFCADESDSIVYNSQSTFVLTKLQKLEFLNSSFPITPQASLLSQHPVLTEFAWIINPNGWWSNAWDEDILSALTTPFASLYKSAFKHHILGVPKRCHQREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSN7</accession>
    <name>A0A194WSN7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065054.1">
        <property type="nucleotide sequence ID" value="XM_018215892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSN7"/>
    <dbReference type="STRING" id="149040.A0A194WSN7"/>
    <dbReference type="GeneID" id="28825618"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689347"/>
    <dbReference type="InParanoid" id="A0A194WSN7"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10836" checksum="DF63935A621ACA26" modified="2016-10-05" version="1">MSFLLRTLPRQSRPLALRASLPTQAFSTTLTQRKSATETVKDAAKTVDRAVSDKLVDGIEIGRMFPLFPLLPLLPHPPFPQQQFHFNIYCDERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSP7</accession>
    <name>A0A194WSP7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_253247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947428">
        <property type="protein sequence ID" value="KUJ10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065326.1">
        <property type="nucleotide sequence ID" value="XM_018206221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSP7"/>
    <dbReference type="STRING" id="149040.A0A194WSP7"/>
    <dbReference type="GeneID" id="28815947"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_253247"/>
    <dbReference type="InParanoid" id="A0A194WSP7"/>
    <dbReference type="OrthoDB" id="5390271at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8856" checksum="0BA138F56ACEFE69" modified="2016-10-05" version="1">METRKTKLGVDHPDTLTSMNNLAFTWKGSGKEIEAVRLMEECVQLRKRILGVNYPDSISFCTALNTWKAEQEDVALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WSS4</accession>
    <name>A0A194WSS4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal trans-2-enoyl-CoA reductase</fullName>
            <ecNumber evidence="13">1.3.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_786673</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2E)-decenoyl-CoA + NADPH + H(+) = decanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44960"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:44961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-dodecenoyl-CoA + NADPH + H(+) = dodecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44956"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:44957"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-octenoyl-CoA + NADPH + H(+) = octanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:44953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-tetradecenoyl-CoA + NADPH + H(+) = tetradecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33764"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PEX5, probably required to target it into peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.38" evidence="13"/>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065365.1">
        <property type="nucleotide sequence ID" value="XM_018223008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WSS4"/>
    <dbReference type="GeneID" id="28832734"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_786673"/>
    <dbReference type="InParanoid" id="A0A194WSS4"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033306">
        <property type="term" value="P:phytol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052388">
        <property type="entry name" value="Peroxisomal_t2-enoyl-CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317:SF7">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="304" mass="31751" checksum="95B893F11D6A7F9A" modified="2016-10-05" version="1">MGSPVAMTDTEHFSPYRADGKLYGFVCIVTGAQQPVGHAIVEELAAHGAACIYACDKGTSSSYTALIESVAKAYPNTKVIGYPFNVAKEDETLGLIDDVLNSWGRLDVWVCSAGLLGPPSLEATTPADLQKCFEANSMAPFFALKYAPPAMGKLCSKQGYPNAAPKDQKYGSIIVVSSVASTYGGCWGPCYTMSSHAALGVVRAGVAVLKGSGVRINCISPGQIDAGVDLQSFDMRGMTAQFPPASLQSKETQKRDIGLERSGLPVEVGRVAGFLASGFSSYITGANMVVDGGASVMNPLTVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WT84</accession>
    <name>A0A194WT84_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_689087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947427">
        <property type="protein sequence ID" value="KUJ11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018065523.1">
        <property type="nucleotide sequence ID" value="XM_018215841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WT84"/>
    <dbReference type="GeneID" id="28825567"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_689087"/>
    <dbReference type="InParanoid" id="A0A194WT84"/>
    <dbReference type="OrthoDB" id="4161611at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9100" checksum="604B75EC14B97F22" modified="2016-10-05" version="1">MDIQEACIHSPLDSTKAQIRVLRLQPRLNPVPDMIVCSLAVADLDHSNCQYEALSYEWGDPKSKELPIVLKGVEVVVRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WTF0</accession>
    <name>A0A194WTF0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_759934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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    </evidence>
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    </evidence>
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
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    </evidence>
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    </evidence>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="5 6">CBS 120377</strain>
        </source>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="RefSeq" id="XP_018066016.1">
        <property type="nucleotide sequence ID" value="XM_018212296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUL6"/>
    <dbReference type="GeneID" id="28822022"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_654351"/>
    <dbReference type="InParanoid" id="A0A194WUL6"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="131"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="411" mass="45798" checksum="5B66AB7815AC06D3" modified="2016-10-05" version="1">MGDYGERSMTPNVASSVIIIGSGCTGLAIAHGLRKAGIPVVVCEKNAAVFSPGERDWNMGLHWGVPILKSLIPDYAAAQLQSVQVDPNTPTKPVDSLAFLNGQTGEVMVAPEIPNFHRLRRSKLRALLAKDLDIRWNKRLKNLVFEDDNSSVIAVFEDGEHITGRLIIGADGARSTVRKLLLGPEIAPSTRLPYSATFVQAKYTHEQALFLRSFHPLYIAAPHPDGYFAFFGLQDAPDADKPEGWTFFFYISWNASLEQQTTERVTFGNKERLAQVKRKSKGYCEPWKSAFEWVPEDQPAWYFDLTVWDPSLPDHQWDTRNGRVTLAGDAAHPMTYQRGQGLNHSITDAGKLVEAITTEAKLATAIEKYEAEMKTRAGEEVKLSVLNTTMLHDWAKVMESPVFKAGLQKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WUS7</accession>
    <name>A0A194WUS7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_688878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066060.1">
        <property type="nucleotide sequence ID" value="XM_018215798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WUS7"/>
    <dbReference type="GeneID" id="28825524"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688878"/>
    <dbReference type="InParanoid" id="A0A194WUS7"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36466" checksum="B2E518797736FE8F" modified="2016-10-05" version="1">MLFEVPGEVKSASLNTAAAPFPDFLIDNHSLPDLVPQYHAASMSNSLADSPESQAIRHEIADLEKRLRDANARLNSIEDREEADSNAPSKVLRSDGPFSASSHHFLLLLSDSALPLGSFAFSSGLESYLAHSRPSSSFPAFLEFSLSSYASTTLPFVLAAYRKPEDLLDLDDALDAAIMCTVGRRASVAQGRALLSIWDRSFSSALPPGASGAAVESLKGIAGLMKSASSKESSDLPPASAHLGPLFGTIACLLGMSLQQTAYVFMLSHVKALLSAAVRASIFGPYHAQKLLASVEVQEGIQAVIDQQWNTKIEDAGQSVPVMDLWIGRHEMLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WV19</accession>
    <name>A0A194WV19_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_213058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066168.1">
        <property type="nucleotide sequence ID" value="XM_018205884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WV19"/>
    <dbReference type="GeneID" id="28815610"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_213058"/>
    <dbReference type="InParanoid" id="A0A194WV19"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="98" mass="10858" checksum="06480A54FA5A061E" modified="2016-10-05" version="1">MNACGGSNSSSPGSGQNFEWPMSVQFWALYPTPKPMEKHIAAKAARRRPVLTAALTDDCFDVRSLSSFTSSSGTALYWLLDIFIFLLLNGRMIEMGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVI3</accession>
    <name>A0A194WVI3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_541006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ11971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066326.1">
        <property type="nucleotide sequence ID" value="XM_018208175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVI3"/>
    <dbReference type="STRING" id="149040.A0A194WVI3"/>
    <dbReference type="GeneID" id="28817901"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541006"/>
    <dbReference type="InParanoid" id="A0A194WVI3"/>
    <dbReference type="OrthoDB" id="3827557at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="108" mass="12555" checksum="285C9C8166B3AB55" modified="2016-10-05" version="1" fragment="single">SGEKNRYWIPNLDINKKVITQEIQYYLGPESTVRPYTREGEDGFLITTPGECLTDEQIDDICRKSKEVWEKQAAARSKKDADKPLKRPLHQPIVVSRASRTDSTRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WVX2</accession>
    <name>A0A194WVX2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_674304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947426">
        <property type="protein sequence ID" value="KUJ11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066097.1">
        <property type="nucleotide sequence ID" value="XM_018213431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WVX2"/>
    <dbReference type="GeneID" id="28823157"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_674304"/>
    <dbReference type="InParanoid" id="A0A194WVX2"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="26506" checksum="2AA8844378D2C6A6" modified="2016-10-05" version="1">MHGRWCGVGAGFVLARRCSGSSRDGRSVSTSLSTARSCLVEDLITTFLDSRDQIATRSATGCLDYTSTTRSVGPQDGTSRRVAFFLADAVISYGAVGPQNLNFGRIQCKSSVGNAVKARGSQFPLDERVKDADGPDVDVAWSRGDNDDGIEDENAVGCTERPRDRKRSLASPKTKTNANHDHTKTSLPTLALGRRRGLAVCCAVSLHSRSHKFNSISTTEMCPGAEVQARSKDVGRDRVDGPGEGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WW79</accession>
    <name>A0A194WW79_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_593846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066580.1">
        <property type="nucleotide sequence ID" value="XM_018209772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WW79"/>
    <dbReference type="GeneID" id="28819498"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_593846"/>
    <dbReference type="InParanoid" id="A0A194WW79"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
        <property type="entry name" value="YwbE family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ12225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="21928" checksum="05077F8682E0022B" modified="2016-10-05" version="1">MSARHANRSRRPQQPDRERGSGRPRGGFGDSERGPLSYGPVPSTRQVNVGSPVSIVLKVDQPTGHQVQGIVAELLTRGDHPRGIKVRLQDGRVGRVQKMISMGVSTVTAETIAFSRSRYSDFRADATEEPEREASLADYVVKDKRKSKGLKGGSTATTGPDNGHNGTIQNADDSSTISPTVTCPVCGDFQGDEAAVAHHVDGHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWK4</accession>
    <name>A0A194WWK4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_623511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066711.1">
        <property type="nucleotide sequence ID" value="XM_018211017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWK4"/>
    <dbReference type="GeneID" id="28820743"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_623511"/>
    <dbReference type="InParanoid" id="A0A194WWK4"/>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="252" mass="28011" checksum="C4220163AAC77280" modified="2016-10-05" version="1">MTNNEHPEEHTTEQTPLLVDGPADDSHHLESSNLIRFRNAIGINVQSASSNPHELENARRKPSGLYREIIGIQRSRTRQYYIFEYFYYGALIVQILIGAILAALGSLSNVHPTVITTFGVLNTAIAGILALMKGQGLPDRLRKDAYEMKKVQDFIEETDIRLAIEEDVHPGELNDIVQKVFDMYNTARDTAEMNHPTNYAHQVDGPENTGRGTTQSVGHDGTEDDSMGIKSVNRMATNVTTGSKGKTKFVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WWQ6</accession>
    <name>A0A194WWQ6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_593978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947425">
        <property type="protein sequence ID" value="KUJ12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066372.1">
        <property type="nucleotide sequence ID" value="XM_018209776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WWQ6"/>
    <dbReference type="FunCoup" id="A0A194WWQ6">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194WWQ6"/>
    <dbReference type="GeneID" id="28819502"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_593978"/>
    <dbReference type="InParanoid" id="A0A194WWQ6"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="365" mass="41728" checksum="943F412D53087646" modified="2016-10-05" version="1">MQKVIRRSVLAEKQAARRHAKRKETATREWAKSNREQDRHLRREAIDQLKQARLNRREDWELGSLAPKRDVGKSKDTYGTIHTQRMRGTLLHHKDRAEAFQPVGGRYLNIVKNDRVVLLEGRDKGKIGKITAVDKARAECTVEGLNLIDVAVPSYMISAEDPDQRPIRTIEKPVPLASVRLVYPLSDPETGVTRDVIIKKLKNGPIFHDRHLNKTKWSRIVPGLNIVIPWPKTPPKEHKDGPNDTLRIDVEQQTYVPSLLRPPMPGSVIDELRNKFSKFRTRHDPEYIEAKLAEDRAVEEKKKQAAEMRTPLKEINRRERKLRKAKGKGKLSTEMLERIGHIIAKKRGLTMGVVGAPKEALPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WXT7</accession>
    <name>A0A194WXT7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_721624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067100.1">
        <property type="nucleotide sequence ID" value="XM_018218660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WXT7"/>
    <dbReference type="GeneID" id="28828386"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_721624"/>
    <dbReference type="InParanoid" id="A0A194WXT7"/>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21228" checksum="7C286DD061E1CD1B" modified="2016-10-05" version="1">MSSQVEELIPLSLGKGSTMRTFIDHSKPDDSPDHNWVEVTYDGKDDSEVFDVPRHWHREHDEIMEVLEGRMIFNLDDKEMVISAGDPPLLITRGRIHGGRGIKGERVRLTERTRPSGTFKAQFFQDLLQNERFPGFLLATRVFYDGDMFLALPGGFKTLDYLFITIVGFIAKAFVPAKPATLKRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WY77</accession>
    <name>A0A194WY77_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_757068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018066907.1">
        <property type="nucleotide sequence ID" value="XM_018221401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WY77"/>
    <dbReference type="GeneID" id="28831127"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_757068"/>
    <dbReference type="InParanoid" id="A0A194WY77"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25932" checksum="64B2071DFAF2B192" modified="2016-10-05" version="1">MATSNAQKLAQAEQAIDTFLLAFPRILSPPGFPDLQFHGPGEIHGIVILPLWQQTAEFNTNCPHWPHFNTFLDGLAPLMKLITSRISDVLSNPNNLLPDQYAHYPNNFGKAIQAWNIRQSTVLAGQLIQPRILSNMNCFETVRLSAMLASDDPRRPSTSRSSDTVVITTVGDYLYGDMWRHAGDIYKTMDELITLPGKVEILNTRFGVQNNRFTGRRFQLEFFLPDISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYA3</accession>
    <name>A0A194WYA3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_197426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947423">
        <property type="protein sequence ID" value="KUJ12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067301.1">
        <property type="nucleotide sequence ID" value="XM_018205759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYA3"/>
    <dbReference type="GeneID" id="28815485"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_197426"/>
    <dbReference type="InParanoid" id="A0A194WYA3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12468" checksum="20A1419CDD6CBB2F" modified="2016-10-05" version="1">MTSTYVSRSTNVRENHLSQYDCASSPSPSSSQLLSHPYRTSRVAFLHPFRHDLTLLLRSRLRSSGLLSCTRLAGMSSSSTSSLLLCLLGFGLLDASLLHSGLCCAVDGHCDRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYH3</accession>
    <name>A0A194WYH3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Cytochrome P450</fullName>
                <ecNumber evidence="16">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="16">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">LY89DRAFT_688280</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23 24">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="16"/>
    <dbReference type="EC" id="1.6.2.4" evidence="16"/>
    <dbReference type="EMBL" id="KQ947424">
        <property type="protein sequence ID" value="KUJ12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018067012.1">
        <property type="nucleotide sequence ID" value="XM_018215677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194WYH3"/>
    <dbReference type="STRING" id="149040.A0A194WYH3"/>
    <dbReference type="GeneID" id="28825403"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_688280"/>
    <dbReference type="InParanoid" id="A0A194WYH3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000198">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 16" id="KW-0288">FMN</keyword>
    <keyword evidence="4 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0521">NADP</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="19">
        <location>
            <begin position="500"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="671"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KUJ12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118573" checksum="DF0B404FD35AC08B" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194WYK3</accession>
    <name>A0A194WYK3_MOLSC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_198761</name>
    </gene>
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        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        </lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="KUJ13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A194X0B0</accession>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">LY89DRAFT_591672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="28819390"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_591672"/>
    <dbReference type="InParanoid" id="A0A194X0B0"/>
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    <dbReference type="Proteomes" id="UP000070700">
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="69" mass="7841" checksum="086C1C9655E43EA8" modified="2016-10-05" version="1" fragment="single">FLLKLMVAIHIIGGQPARSPEIGSIKVRNSFTLSRNIFVINGRVAIVTTYNKSLKRRGKIEYVFRCFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X0T1</accession>
    <name>A0A194X0T1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_784671</name>
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    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Leotiomycetes</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018222809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X0T1"/>
    <dbReference type="GeneID" id="28832535"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_784671"/>
    <dbReference type="InParanoid" id="A0A194X0T1"/>
    <dbReference type="OrthoDB" id="3534625at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ13806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="107" mass="11842" checksum="CB0A01559F928186" modified="2016-10-05" version="1">MEGKEAYREVSSNLDSQDSKYIDESREQSPQAFDDLKRPEPDPYPLLSTLPESVASFFSTVSSDGFPPDLPKAQPWRQILAAPLPPQQDGKLIIACPKKCLYGSNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X134</accession>
    <name>A0A194X134_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_687238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ13903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068258.1">
        <property type="nucleotide sequence ID" value="XM_018215457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X134"/>
    <dbReference type="GeneID" id="28825183"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_687238"/>
    <dbReference type="InParanoid" id="A0A194X134"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ13903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="58704" checksum="E6467D6AB40B2D63" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X231</accession>
    <name>A0A194X231_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_541099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947421">
        <property type="protein sequence ID" value="KUJ14054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068409.1">
        <property type="nucleotide sequence ID" value="XM_018208177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X231"/>
    <dbReference type="GeneID" id="28817903"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_541099"/>
    <dbReference type="InParanoid" id="A0A194X231"/>
    <dbReference type="OrthoDB" id="4733706at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="165" mass="16858" checksum="44D46C2CE2EDF0FE" modified="2016-10-05" version="1" fragment="single">GQLDVTTGFDITWPNSAFITIDPIKGEILSMDVSGVQVNPLPLTFITGSGCVQVALRFGLKAGLGINLLGTSANIQAGAFVDAPAYQACAEFNSAAPCELGLTQKVFGDAGAFADIAVKIDFLQFSEGPSVVTTFFSADLPTACLASTTTLAIANTTSSKASVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3J7</accession>
    <name>A0A194X3J7_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_621164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068954.1">
        <property type="nucleotide sequence ID" value="XM_018210938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3J7"/>
    <dbReference type="STRING" id="149040.A0A194X3J7"/>
    <dbReference type="GeneID" id="28820664"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_621164"/>
    <dbReference type="InParanoid" id="A0A194X3J7"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="84"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="444" mass="48115" checksum="0DE604EE6EDC5EF4" modified="2016-10-05" version="1">MTSSNGPPHFEYHDGALSWGTTKLLDENIICVTTDHSQSTIFSLTATEEGSQKQFELQITNTTSLPPEFLNRHLLKGLPAYLHPDDNVIHVLISTLSGTGLAPSFFDDVLHPVLLGIGLLDSSYHVLRTENTNSVAEFAKATLLPAAAAGKKQTVLILSGDGGLVDTVNGILEEGNPPSTYRRPVLAQLPLGTGNALFHSLHKPTSAGVPSLYIQGLRTLLHGTPRPLPIFRATFSPSARLLTNEARTASPLKNNTLYGAVVASYGLHSTLVADSDTTEYRKHGDKRFGLVANDLLFPDDGTRPHAYLAEVVLSYDGHKDTVPRGEHGYVLATLVSNLEKTFTISPESAPFDRALRVVHFGALSGEETMEIMKAAYDDGKHVQSDEVGYENVESMRINFKESGESWKWRRCCVDGSIVGVEEGGWMEVSLLGSGEEVVDVVADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X3K3</accession>
    <name>A0A194X3K3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_686428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069128.1">
        <property type="nucleotide sequence ID" value="XM_018215284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X3K3"/>
    <dbReference type="GeneID" id="28825010"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686428"/>
    <dbReference type="InParanoid" id="A0A194X3K3"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="105" mass="10716" checksum="F16C05D473E620DE" modified="2016-10-05" version="1">MSSSSSSSSSGVGSGCTATLQCDVLAGTYVVPSHESEPATACHPCAAGKGSTRLFLTAVCWSRGTVPVFTPTLSYPASYLPPIDRVRSLSLSLSLEASAGKMNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X415</accession>
    <name>A0A194X415_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_650444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947420">
        <property type="protein sequence ID" value="KUJ14562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018068917.1">
        <property type="nucleotide sequence ID" value="XM_018212107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X415"/>
    <dbReference type="GeneID" id="28821833"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_650444"/>
    <dbReference type="InParanoid" id="A0A194X415"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 120377</strain>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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                <person name="Seifert K.A."/>
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X4N2</accession>
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        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
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    <organism evidence="13 14">
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">CBS 120377</strain>
        </source>
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        <subcellularLocation>
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    <comment type="similarity">
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    <dbReference type="OrthoDB" id="1076608at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Csc1-like"/>
    </dbReference>
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        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="215"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="465"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="929"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114410" checksum="12E6315A7838ED47" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X518</accession>
    <name>A0A194X518_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_708507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947419">
        <property type="protein sequence ID" value="KUJ14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069252.1">
        <property type="nucleotide sequence ID" value="XM_018217685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X518"/>
    <dbReference type="GeneID" id="28827411"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_708507"/>
    <dbReference type="InParanoid" id="A0A194X518"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="450" mass="52178" checksum="49CAE235C736CC06" modified="2016-10-05" version="1">MIEGPDDFDYLVWDKNDEEWEIVQPKLRQRSTLHAVEDLGTAKFGSTAKWVSPMSIGGYNIIYRLKVEGFDSEVLVRRPIPCYAQFPVEKTSIEAVTMMNLKKHTKIPVARTFFHGEDPKLGSFIIMEYIEHSRCMSTAYNATNEDVSKPFTLNPDIPEEVLQNHYQHVAACLLELSQHTFPRIGSLVEVNPGTFSIAARPVTKNMNDMLQLANIPGMHIAQLVFRQNDLVRTEQECRNKYVARQLFRRLARDGKLSKFGFKEDNWSAQSKTKSMKLSSMPSNSDSFRLYCDDLRPSNILLTASDAITAIIDWEFTYAAPSQFSLDPPWWLLLDTPDQWDAGLDNWITLYEPRLETWISAMQKAEEDTKLNGGIAGVPLSTFWLTYVARKSWAFETIFWKYLDERFFGPREQGLPRNHYWKARIDLLSEDERNAMEPFVEQKMETRKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X619</accession>
    <name>A0A194X619_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">LY89DRAFT_686034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="KQ947418">
        <property type="protein sequence ID" value="KUJ15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018069607.1">
        <property type="nucleotide sequence ID" value="XM_018215193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X619"/>
    <dbReference type="FunCoup" id="A0A194X619">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X619"/>
    <dbReference type="GeneID" id="28824919"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_686034"/>
    <dbReference type="InParanoid" id="A0A194X619"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="101"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KUJ15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="204" mass="22575" checksum="0586DCB7CED79FF4" modified="2016-10-05" version="1">MASTSFVRGKATLPDLPYDYGALEPSISGKIMELHHKNHHQTYVNSFNAASEQLEAAESKEDIAAQIALQPLINFHGGGHINHTLFWENLAPSKNGGGGEPAGSLKTAIESSYGDFSQFKTKFNTALAGIQGSGWAWLVKDNETGQVQIRTYANQDPVVGKYTPLLGVDAWEHAYYLQYQNRKAEYFSAIWDVINWKAVEGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X728</accession>
    <name>A0A194X728_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_98212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070249.1">
        <property type="nucleotide sequence ID" value="XM_018223554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X728"/>
    <dbReference type="GeneID" id="28833280"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_98212"/>
    <dbReference type="InParanoid" id="A0A194X728"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="512" mass="57142" checksum="1A905051E5BAECEA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X7F6</accession>
    <name>A0A194X7F6_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_670549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947417">
        <property type="protein sequence ID" value="KUJ16024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070379.1">
        <property type="nucleotide sequence ID" value="XM_018213169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X7F6"/>
    <dbReference type="GeneID" id="28822895"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_670549"/>
    <dbReference type="InParanoid" id="A0A194X7F6"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ16024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24677" checksum="40CCE938BBA64FDB" modified="2016-10-05" version="1">MLQDRLNDAAIALSRVLSDARIKFGIFGGYAIAVLGGQRESKDIDCVAALSKQAVISLFDGKLGFVAVPQTREDYVAFLWSNTPNRSNAVLVEIFCEQFPGARYSMSNVQPNAVAINGASLGNGTAPFLDPVYLFKGKLRAAATRAKFHDSADLRWLEGRFRETIKARRAEFSSKYVGLAMKRYAELEPLFIRLGIDVAVAKDAAANLDPNNLPRPAPGDVQLGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X850</accession>
    <name>A0A194X850_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_80342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947416">
        <property type="protein sequence ID" value="KUJ16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018070700.1">
        <property type="nucleotide sequence ID" value="XM_018223421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X850"/>
    <dbReference type="GeneID" id="28833147"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_80342"/>
    <dbReference type="InParanoid" id="A0A194X850"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="248" mass="27955" checksum="739EFF8677C38A46" modified="2016-10-05" version="1">MPPPPLALSPALPSELLTYVLTHQIYPTTLLICQPRNVFLTSLLSSIPQPIQRQPPPPETHLPDPEDEDPPPRHPLLIPTLHQIATSRSVNVVFIPTVSHLRAYLSVFPPPTENASPPEPKLDKPGKEVPLLVVYGLVDLHRDTSEWSAQGFGNSVASLVEAGRRGDRKIVVIEEKKEEDSSYVVEGEEVERKPGWKVWDERVPMLNGNIRRAGFESEESAWSGRTIEIGRIYARWFRFGRGDWDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X930</accession>
    <name>A0A194X930_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_733684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071033.1">
        <property type="nucleotide sequence ID" value="XM_018219833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X930"/>
    <dbReference type="GeneID" id="28829559"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_733684"/>
    <dbReference type="InParanoid" id="A0A194X930"/>
    <dbReference type="OrthoDB" id="3560099at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="74"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ16678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="331" mass="37494" checksum="5E571C00698A15B7" modified="2016-10-05" version="1">MTQSSSGSMVQIPVDILQSLVTSIDALRHEVVNLRQERLTLQFQTPNPATPASTITTQSEVPRDDTTEEYGKTFQCFNKLPPEMRDAIWRVAAKAPRVVTAKIAPRSGPESSDTVYAPSALPPMLSVSKEPRKVALEVYTCFTDPETRLPRLYMQPDIDTMLLLNRDFNRVFQGKARKMWRKTPKFKHLALDWKFCHELLLHANDDRVIQGMFNVLAITGVKVVSIVLGDIDESVENVAFGSPRGCPEELRCRNLQAFLIARRGKAVGECSWRTIVFLISEYMQAILDRNLSVDRITASVPRETDNALQKYANGLWVPPRFRYVTIKGQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X942</accession>
    <name>A0A194X942_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_645565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071046.1">
        <property type="nucleotide sequence ID" value="XM_018211887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X942"/>
    <dbReference type="GeneID" id="28821613"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645565"/>
    <dbReference type="InParanoid" id="A0A194X942"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="346" mass="36827" checksum="CD1E804EBDCF507E" modified="2016-10-05" version="1">MATHLVYRLTNRGPKCTIKQVSERRPTPDKHEVLVKIHAVSLNYRDIVIANGTWPFPAKDNLIPCSDSAGKVVAIGSDVEGFAIGDKVVAAFDVATLYGPLKDWNHGHGGPIDGVLREYAAFPASVLVKIPSESKLGFPQLSTLVCTGVTAWNALYGNIPLKPGQTVLFQGTGGLSITGLILAKAAEATTIITSSSSAKLALVKSKYGVDHTINYKTTRNWAAKVNKITNNNGVVFILENGGSGTIKQSLECITAGGIISVIGFLSPAKQKDMPDVAGLALAKGVVVRGITVGNRNMLKDLVRFVAARGLERPVDKTFGFEQAEVEAAYEYLKSGKHVGKVCISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X972</accession>
    <name>A0A194X972_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_645599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071076.1">
        <property type="nucleotide sequence ID" value="XM_018211888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X972"/>
    <dbReference type="GeneID" id="28821614"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_645599"/>
    <dbReference type="InParanoid" id="A0A194X972"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34342" checksum="9F24171D7B9484D7" modified="2016-10-05" version="1">MLTKLRFLEDSPRFETEIPYELYGHPKFDSGRITNCTYTEVDNILIEDVRQNPKNFTLENAGFTYITHESICSLASEHFETAGSNLEKSPIVTAYLEETMSLVKEQTSADRVICFDWRFRRSGGPNDIKSDPFEVEDIRFQAVRPGFLVHCDFSHDGGLERLEMHLLPEELELVRSGKVKARIINVWRPLGTVKNAPLVLTDRRSVHKEDLIEVEKVLPDKVERAYFVKYQAYHRWYYLSEQSPKDVAMFVTWDCDEEEVKAAYPPHGAASQFTEDPYECPRESVEARLIVFTSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9G9</accession>
    <name>A0A194X9G9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_585086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071166.1">
        <property type="nucleotide sequence ID" value="XM_018209306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9G9"/>
    <dbReference type="FunCoup" id="A0A194X9G9">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194X9G9"/>
    <dbReference type="GeneID" id="28819032"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585086"/>
    <dbReference type="InParanoid" id="A0A194X9G9"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="124"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="612"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ16811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="850" mass="96582" checksum="38647456F714A878" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194X9I2</accession>
    <name>A0A194X9I2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_585653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KQ947415">
        <property type="protein sequence ID" value="KUJ16789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018071144.1">
        <property type="nucleotide sequence ID" value="XM_018209333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194X9I2"/>
    <dbReference type="STRING" id="149040.A0A194X9I2"/>
    <dbReference type="GeneID" id="28819059"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_585653"/>
    <dbReference type="InParanoid" id="A0A194X9I2"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="156"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ16789.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="779" mass="86601" checksum="4A7F71F845D7DBAE" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
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                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="2 3">CBS 120377</strain>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ17729.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XCG5</accession>
    <name>A0A194XCG5_MOLSC</name>
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        <lineage>
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="533"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ17854.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XCN9"/>
    <dbReference type="GeneID" id="28822748"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_668145"/>
    <dbReference type="InParanoid" id="A0A194XCN9"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="841"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="139"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KUJ17935.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
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    </gene>
    <organism evidence="6 7">
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        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072470.1">
        <property type="nucleotide sequence ID" value="XM_018222461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XD62"/>
    <dbReference type="STRING" id="149040.A0A194XD62"/>
    <dbReference type="GeneID" id="28832187"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_781207"/>
    <dbReference type="InParanoid" id="A0A194XD62"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268092" evidence="2">
        <location>
            <begin position="22"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="126"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="472"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ18115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="758" mass="84852" checksum="7116FDCDD041FAC6" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XDV0</accession>
    <name>A0A194XDV0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">LY89DRAFT_717920</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947413">
        <property type="protein sequence ID" value="KUJ18353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072708.1">
        <property type="nucleotide sequence ID" value="XM_018218380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XDV0"/>
    <dbReference type="FunCoup" id="A0A194XDV0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XDV0"/>
    <dbReference type="GeneID" id="28828106"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_717920"/>
    <dbReference type="InParanoid" id="A0A194XDV0"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KUJ18353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="148" mass="15878" checksum="E6338C59A5BEBC4C" modified="2016-10-05" version="1">MSYSSRPLPSHIRQASTSGNSTSNGQSPILLARINEKKAELENLKQLRDLSAGLAGQMQMLEEKLSTLSDGTEAVATVLGNWHNVLRAISMASMKIPKPKENSEDAEPKNDETTSDPAMPLPQTLVRIPTEHAPMLQQNSTGGGASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XEE8</accession>
    <name>A0A194XEE8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_498298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072874.1">
        <property type="nucleotide sequence ID" value="XM_018207939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XEE8"/>
    <dbReference type="GeneID" id="28817665"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_498298"/>
    <dbReference type="InParanoid" id="A0A194XEE8"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30613" checksum="9B0B7671D77883FE" modified="2016-10-05" version="1">MQEDDPWIEGKGRPPNFYYTQQRILHSAAEKEGWEWVVTYPNDVIGVARGNFMNLSTSLGIYAAVSKELNNGELEFPGSETFYNMFDCFTSSRLHAAFNLWAALEPGCRNQAFNVVNGDAETWANLWPKVARRFGCKVPARQFERETPDASEMKLAEVPPFEDLAAVNGMKGKVPQGKVSQRIDLVRWCQKKDVKDAWAKIAEREGVEKGALEKATWGFLGFVLGREYNIVISMSKARKFGWTGYVDTWESFEETFDELEKEKVIPEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XER0</accession>
    <name>A0A194XER0_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_643035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018072991.1">
        <property type="nucleotide sequence ID" value="XM_018211779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XER0"/>
    <dbReference type="STRING" id="149040.A0A194XER0"/>
    <dbReference type="GeneID" id="28821505"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_643035"/>
    <dbReference type="InParanoid" id="A0A194XER0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ18636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="545" mass="61307" checksum="A52F114BF61FF2E8" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFS3</accession>
    <name>A0A194XFS3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative histidine kinase M3YPp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_581896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073334.1">
        <property type="nucleotide sequence ID" value="XM_018209131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFS3"/>
    <dbReference type="GeneID" id="28818857"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_581896"/>
    <dbReference type="InParanoid" id="A0A194XFS3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="521"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="847"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="976"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ18979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112149" checksum="F68F296712D30A61" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XFV8</accession>
    <name>A0A194XFV8_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_501267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947412">
        <property type="protein sequence ID" value="KUJ18657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073012.1">
        <property type="nucleotide sequence ID" value="XM_018207965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XFV8"/>
    <dbReference type="FunCoup" id="A0A194XFV8">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XFV8"/>
    <dbReference type="GeneID" id="28817691"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_501267"/>
    <dbReference type="InParanoid" id="A0A194XFV8"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ18657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13300" checksum="611785EE512113AC" modified="2016-10-05" version="1">MAPPSALTIATSSVQRLMKEEASYHKELKSQESRLEKLLASKSEDENAEYSLKQERTAIEETKAVFPPLTERLEDAVHKLEDKLDAERDNGASAEEVSKAEGVITDAKKVIADARAAAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGK4</accession>
    <name>A0A194XGK4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_780274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073653.1">
        <property type="nucleotide sequence ID" value="XM_018222368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGK4"/>
    <dbReference type="GeneID" id="28832094"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_780274"/>
    <dbReference type="InParanoid" id="A0A194XGK4"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="413" mass="46129" checksum="AEF8F4071B0AD8D0" modified="2016-10-05" version="1">MDPGYLDTTPVRPPPPGQTSNFINPVSRSYQLVAVIAVTFALVVLFIGFRLYFRLKVTKSFGADDWLCIVATILTLSYSALILKLLWKPGGGILGIHLWDVPLSHYIEYSKGSLADSVLIRITNTSIKVAFFVWYLRLFSVIKYVKIMVLVGMVTVITFCVAFITIDLVACCPWPSEHGGWLDPKMLSRCNKIAPNLVTSGAYFSVITDFYILFIPLHQVPGLNLSRNKKIGLSFIFLTGTLACAAGLTNLIIRQDKKIFDPADFSWTIVPVYATSIVEINVGLMCHSMPIVLFQFVTRLSHIGTSLSSWIRERRERRRSPAESSSNLAASADEDNPPPQLPEVPSGNNNLTGIRTFVQNIYRSGAQTSKREETVLPTFKEELTSVDPSYHHGLKSIRPTHIEDSRQTNNSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XGY1</accession>
    <name>A0A194XGY1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative peroxisomal adenine nucleotide transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_613014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073744.1">
        <property type="nucleotide sequence ID" value="XM_018210649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XGY1"/>
    <dbReference type="STRING" id="149040.A0A194XGY1"/>
    <dbReference type="GeneID" id="28820375"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_613014"/>
    <dbReference type="InParanoid" id="A0A194XGY1"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="240"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ19389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="476" mass="51420" checksum="B717F0B965B2638D" modified="2016-10-05" version="1">MANIYNSQLDAYSLYHKNQEASSPSALNGPALPALGHALAGSTGTAISNLAIYPLDLVITRLQVQRSLRKSSASQDEYKGVIDAFDKVYHNEGGIKAFYSGVVQDTGKSIADSFLFFLFYNYIRTNRLQKKGLSATTLPVFEELAVGTIAGACSKFFTTPIANIVTRKQIATMVAARSSTSLAEPSAREIAADIRNEKGLQGFWSGYSASLILTLNPSITFFLYETFKRAFLPRSERDNPSTHVTFIMAAMSKAIASTITYPFSLAKARAQTSSKRPVDSESAEIIMKEAENVENRSDVKKVGQDAKKFAQSNTVFDTILKIYRTEGAAGLYEGVFGEILKGFFSHGITMIIKETVHKMIIQAYYLVLKALNRYPSPSELAKQAGQSVQDAGEKAGDLVKGGYNNVTEAVSNMVGGTKETAGVAAERVGVIGNNTTEAAKTANDYASKEAGHLLGNAQEMLGGKIERVGQGIKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XH65</accession>
    <name>A0A194XH65_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyamine transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_695986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947411">
        <property type="protein sequence ID" value="KUJ19469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018073824.1">
        <property type="nucleotide sequence ID" value="XM_018216796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XH65"/>
    <dbReference type="GeneID" id="28826522"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_695986"/>
    <dbReference type="InParanoid" id="A0A194XH65"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ19469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="491" mass="53790" checksum="B67582E8BACB546D" modified="2016-10-05" version="1">MPMAETSLSPEREDNTTVPDLKTQTQDGRYPSEVLEDEVWDGPDDPDNPLNWSPSQKWSIILLISTITLVFSSSSSIFGPALPEFLREFDSKSDTIATLTISEYAAGYILGPLVIAPLSELYGRLPVVHASNLVFVVFTVACAVSSDIPMFITFRLGQAFSVYGTGTLGPSFIADLMPIERRGLAMTIFAVGPTLGPSISPTIGGILALKAGWRWIFWFIAIFAGILTILTAVILKETYAPILLARRHARKQNPLGTTQAPTPASVIRAAIVRPVKLLIHSPVTLILALQSSIALSYLNLILSTFALLFQTQYNFTTWQSGLTLFGLGVGFIVGQLVVGSFSDGWLKHQNSRRNEIRPEDRLPPLIIGSILIPTGYFWCGWSIEYHTHWIVPIIGSALVSTGAMFCFLPVSMYLIDAYTVFAASATAGNIMVRSIVSAILPLAAEPLYGKVGYGWGDSIFAFIALAFLPVPIFLVRYGHYLRTHPRFQVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XHZ1</accession>
    <name>A0A194XHZ1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_460429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074133.1">
        <property type="nucleotide sequence ID" value="XM_018207681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XHZ1"/>
    <dbReference type="STRING" id="149040.A0A194XHZ1"/>
    <dbReference type="GeneID" id="28817407"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_460429"/>
    <dbReference type="InParanoid" id="A0A194XHZ1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="369" mass="40112" checksum="CBB03478128A469D" modified="2016-10-05" version="1">MADPSSKPDLGKVVVIGGCGFLGSHIVDALRSTCKAEIFVVSRSATKYPDHHPDVKYIDVEINKTNAAGVPDIESVFAENKIDVVFHTATPSALTGKEQEFEEVNIKGTNNVILAAQHTGVKAFVYTSSQAVTLPNFQEGASNADESWPLILGKDQADLYARSKAAAEKAVIEANHPGGLRTCALRPGGMVGIRDNLVTPTIGNLYFNGDPNTQIGDDTALSDYGSVLDTARTHVSAAVALLRAHSSPTPIPESERVDGEAFYITGEHVRFWTFARSFYKHFGNKADKKPTVLSKGFALILARVLMFFFGLVGKESPLKVNDVYYACATMTASNEKAKKRLGYEVREPIDVAVEKASKWYLENRRPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XIS9</accession>
    <name>A0A194XIS9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tom7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_731369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074495.1">
        <property type="nucleotide sequence ID" value="XM_018219566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XIS9"/>
    <dbReference type="FunCoup" id="A0A194XIS9">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XIS9"/>
    <dbReference type="GeneID" id="28829292"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_731369"/>
    <dbReference type="InParanoid" id="A0A194XIS9"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="52" mass="6032" checksum="1166003E0F1487B9" modified="2016-10-05" version="1">MQLSEESKERIGKVIDFSRVAIHYGYLPLIIYLGYTYSEPRPSLIRLFSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XJ61</accession>
    <name>A0A194XJ61_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_682941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947410">
        <property type="protein sequence ID" value="KUJ20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074519.1">
        <property type="nucleotide sequence ID" value="XM_018214606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XJ61"/>
    <dbReference type="FunCoup" id="A0A194XJ61">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XJ61"/>
    <dbReference type="GeneID" id="28824332"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682941"/>
    <dbReference type="InParanoid" id="A0A194XJ61"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="296" mass="32677" checksum="1BAEB7EEE01EF087" modified="2016-10-05" version="1">MSTTTHTTEEIDQTKAPSIHLTNLSYTFPSTHSGLSNLTLSLPPKSRTLLIGANGAGKTTLLRLLSGKRLAPSNTISIGGLDPFKDGLEGVTYLGLEWVLNPIVRTDIGVKELLKSVGGDHYPDRKDELVRVLDIDLDWRMHAVSDGERRRVQLAMGLIRPWRILLLDEITVDLDLLSRSNFLAFLKKETETRECTIVYATHILDNLAEWPTHLVHMSLGKVKEWGEIEGFELGEKGYGKTGNSRLGELVLGWLKDDLRERGPRNKGTTSEGTAYLTGGLGGYGAEDAIKAGKRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XK68</accession>
    <name>A0A194XK68_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">LY89DRAFT_682259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018074891.1">
        <property type="nucleotide sequence ID" value="XM_018214470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XK68"/>
    <dbReference type="FunCoup" id="A0A194XK68">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XK68"/>
    <dbReference type="GeneID" id="28824196"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_682259"/>
    <dbReference type="InParanoid" id="A0A194XK68"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268335" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KUJ20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22985" checksum="7D10E75CF727D1C0" modified="2016-10-05" version="1">MKVSTSSLLLAASTLLGTALSHNIQLAAHGRECFHEMLHKDDKMTVTFQVGDREFGSAGNLHVDFWIQNPSGGYETHERSVSNGDHSFTAQHDGKFVYCFSNEHWSASSKDVSFNVHGIVYVPEAEAPSDPLEAEVRQLSELLAQVKDEQSYIVVRERTHRNTAESTNARVKWWSIFQMGVLAAEGVFQVWWLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XL13</accession>
    <name>A0A194XL13_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_455760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947409">
        <property type="protein sequence ID" value="KUJ20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075176.1">
        <property type="nucleotide sequence ID" value="XM_018207633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XL13"/>
    <dbReference type="STRING" id="149040.A0A194XL13"/>
    <dbReference type="GeneID" id="28817359"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_455760"/>
    <dbReference type="InParanoid" id="A0A194XL13"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="319" mass="35460" checksum="EABEBFE003AF859A" modified="2016-10-05" version="1">MSVTDWNTGDKSAMLSIGTHKLFLSASGPDRKSGEPVILLMQGLGSTINEWVAVRRLVLPLARWVNYDRSGLGRSEAPPQQPDSISAASVASELDTLLKNAGIEPPFIVVCHSWGGMTAREFLHLRQKDVVGIVFVDANTEKSYDAGNWPLPFVIAVTDGVDWLESTGLEADHVLSDKEWAQVKEAENDPQLQKTVVAEQRGFRSDSAPLASKHQIERQVLGSHPVSVITCNSARDMQRMYESGVAAGKGTEAEREQFRNMLVDHNQRQTDWQQDLLRLSCNSRFIRVDNSGHNVQLVQPAVVAREIRWVWDSVQVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XM35</accession>
    <name>A0A194XM35_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_729993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075556.1">
        <property type="nucleotide sequence ID" value="XM_018219425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XM35"/>
    <dbReference type="GeneID" id="28829151"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_729993"/>
    <dbReference type="InParanoid" id="A0A194XM35"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="242" mass="27868" checksum="C43D130FA3DE6929" modified="2016-10-05" version="1">MDTKASQSKKCSRNFYHFSCGHRGLRQELPSYTHSSTCGKWDPDHTCENIMLGLNVAKVEMECKHCAPEPPAVAEPAATAATVKSITTAAGIERLKEIRANYENNEILRKVRHQELEKQEKAEFEKCAERKEIETLRQLRRQEREKKEKAKEEALAEEIEKLKAKTVRQKAYIAACKASLAEREASLAEFQRKYKAEANGLEKEAEAEARRVEDLRLEEQKLATEMVEMEMEDQELKDWVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XMZ3</accession>
    <name>A0A194XMZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_681988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947408">
        <property type="protein sequence ID" value="KUJ21496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018075851.1">
        <property type="nucleotide sequence ID" value="XM_018214413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XMZ3"/>
    <dbReference type="STRING" id="149040.A0A194XMZ3"/>
    <dbReference type="GeneID" id="28824139"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681988"/>
    <dbReference type="InParanoid" id="A0A194XMZ3"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="186"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ21496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="357" mass="39591" checksum="F8F50D0CC4F5A80B" modified="2016-10-05" version="1">MSKNTMKAVVFKGTLKVEIEDRPIPKIVDQTDMIIKVKYSALCGSELHVFRGHQPSKTDFIMGHETTGEVSEIGSAVKNHKVGDTVVMPFTVSCGECFYCQKGFSSRCEKCLLFGCPLLDGGQAEYMRVPLADATAVKAPEGIDEKKLVLMADIFPTGYFAAANAFRGFDEETIHQSVVVLIGCGPVGLCALINALEYKPRVVIAVDRVESRLELAKKLGAEPWNDQKDRAGLEKRVKELTDGRGADTIIEGVGHADALKTGFELMRPWGNISSFGVHNEEIPWTGNQAYGKNLRIQMGRCPVRSIFPQALEMLKKKQHLLDFMTDKFMPLSEAIEGYDIFNKMQVQKVVFVPEHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNR9</accession>
    <name>A0A194XNR9_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">LY89DRAFT_637907</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076235.1">
        <property type="nucleotide sequence ID" value="XM_018211553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNR9"/>
    <dbReference type="FunCoup" id="A0A194XNR9">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XNR9"/>
    <dbReference type="GeneID" id="28821279"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_637907"/>
    <dbReference type="InParanoid" id="A0A194XNR9"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008268518" description="GPI mannosyltransferase 2" evidence="13">
        <location>
            <begin position="33"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KUJ21880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="443" mass="48693" checksum="FF66B26C59626ECA" modified="2016-10-05" version="1">MQFLTRNLDHPIRKLVALFLCWKTLLLLVALCSPGPGYDTSGSLTEASHGKEQLPVALRHTISKLIRWDALYFVKAAERGYSFEQEWAFGWGFTRVIAACTEFLKAAGIPHYDGLEAWVAINLAHIAHLISVLLLFYLSSDVFPGSSQNFALTAASLHVISPAGLFLSAPYAESSCAALSFAGCLLFMKSLNRNGRATAIHDLYLILAGVSFGIATTFRSNGILNGLLLLEEAFRTLFVLSYERSGATLRRLLAAGLGGMCVGSGFLLPQYIAYQEYCGCKDTVPRIWCQGTLPSIYSFVQSHYWNCGPFRYWTVSNIPLFVLGTPIFTILIVSGLWALQYTAANGPPRATKQYDVKSSQISFGREGISVLRNMAVSQLFLAGMTLTTAHVQIITRISSAYPVWLWYLAASSHEGRLLGIFVKFMVLYGVIQAGLYASFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XNT4</accession>
    <name>A0A194XNT4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_387569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076250.1">
        <property type="nucleotide sequence ID" value="XM_018207162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XNT4"/>
    <dbReference type="GeneID" id="28816888"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_387569"/>
    <dbReference type="InParanoid" id="A0A194XNT4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ21895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="196" mass="21342" checksum="F70220E99A896497" modified="2016-10-05" version="1">MHRRLQTYPSQPSPAQPGILMLATAAAAAAALTSIVSLHKILSCASLGHFSRLFLFLLPLLSPIASIRLDLTSPHLTSPHLTSPPLTSPHLPSTSSSFLLRPVCLCVCRLSNVNGRGRQQRKLSNSRYIQACIWWNKDISGATSRTRFPRDNHPTISTPHLSHEPASTVTGHIADSATRATYLHRCTSGSDKSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XP16</accession>
    <name>A0A194XP16_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_681271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ21911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076266.1">
        <property type="nucleotide sequence ID" value="XM_018214249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XP16"/>
    <dbReference type="GeneID" id="28823975"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_681271"/>
    <dbReference type="InParanoid" id="A0A194XP16"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ21911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="221" mass="24724" checksum="87343804CD7431AF" modified="2016-10-05" version="1">MTNFDIEIVSDTVCPWCYVGKQKLEKAIKAYKELHPESNDSFSTTWKPYYLNPGAPKTGIDKTTYYKTKFGEERTAVIFDRLSQVGKEAGIKFKFGGKTGNTRDSHRLIQLGKSKSPAVQTRVVEELFSAYFENEKDITSHEVLLSAAKKAGLDEKEAKEWLESDKGGKAVDEEVEEARLNQISGVPNFTFEGKYIVGGAQDSEVFLNLFEKIKASKSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XPY1</accession>
    <name>A0A194XPY1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_606746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076670.1">
        <property type="nucleotide sequence ID" value="XM_018210431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XPY1"/>
    <dbReference type="GeneID" id="28820157"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606746"/>
    <dbReference type="InParanoid" id="A0A194XPY1"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ22315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="355" mass="39545" checksum="3C0E3DE3C83B4FB3" modified="2016-10-05" version="1">MVLGLHGHSHVDINSIKNSHPDPTTSIYPQLSPDDAPYQVQEVDMRSAIFIPEEFQYGRDGKVPVILVPGTGSFGGEAFRCNFAKLLKASNFGDPLWLNIPGMMCDDAAKNAEYVAYAINYISTTCSKKVAVIAWSQGNLCVQWSLKYWPSTRGQVSNFICLSADFRGTTNAWLMAPAAGVPCAPAVRQQRRRSKFITTLMSNGGDSAYVPTTSIYSRTDEVVQPQFGKWASALMYDERQVGVTNCEVQVAACKKPAGLYYTHFTLLYNPLAWAFTEDAICNGGPGRLDRIDMKCCMRTKTHGLNRLDVLRTKELIRCGKAILNYPAKLKYEPELPPYCAREEKTYVPDYEADIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQ58</accession>
    <name>A0A194XQ58_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_694532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947407">
        <property type="protein sequence ID" value="KUJ22189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076544.1">
        <property type="nucleotide sequence ID" value="XM_018216711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQ58"/>
    <dbReference type="GeneID" id="28826437"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_694532"/>
    <dbReference type="InParanoid" id="A0A194XQ58"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
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            <begin position="251"/>
            <end position="271"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="308"/>
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            <begin position="342"/>
            <end position="361"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="452" mass="50729" checksum="D5C7AB64A751A534" modified="2016-10-05" version="1">MTVDNIQITPEERRRVVRKLDLHLLPLCFILYTFSVLDRSNLGNAKLAGLAEDINISGDKYTWLANLFYIAYIIFQFSNLGWKIFKPHKWVTFVVLYWGIVSTLQAVCTSWQGLMACRFFLGWAETMFGPGIPLYFSFFYPPEYLGLRFGIFLSGSALANAYGGALAYALSHIHSSVANWKFLFIIEGVPTVLLAVATWFFLPDSPEKARFLNERERLVAEAFAQNQPGDFEHEGLQVSQLMDAFKDYRNYFFALLNFSCNVSFASLPLFLPTIISELGTFSQLESNGLSAPPYLLCFFVIIATAIVSDRVRLRGPFASFFALLAAIGFIILGTATSVTARYVGIFLTVNIFVTTTIILIWNSNINATGSKRAGGLWIMMTVGQCGTLLGTNIFPSSERPFYRKGMWIACSFSLLAAVASAVLSTLLFLENRRRDRKYGRLGIARRLKFGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQD4</accession>
    <name>A0A194XQD4_MOLSC</name>
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        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">LY89DRAFT_390052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
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    </dbReference>
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        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ21947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111815" checksum="91D73F73CF59D6B9" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQM2</accession>
    <name>A0A194XQM2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_575826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
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        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="28818537"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_575826"/>
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    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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            <end position="497"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
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            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ22570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="510" mass="57907" checksum="5C988C6B9F4E9BB8" modified="2016-10-05" version="1">MRDGKFTPEFDAFVKEKLDKWHVPGMSIAVIQGDDVCAKGYGFARLPDEPVRPETLFNCASMTKAFTATATSLLVDDKNHPDVKWDTPMSHLIGDDFVLSDGRYTAEVTIEDMLSHRSGLPDCDDACYGIYAKNPDNTKSIVRKLRHIPLVSPLRTTYNYCNVGYTVVAHMIERLTGQWFGDFLREKIWEPLGMKNTYYGLDDLRKRRGTDDLAKSYRWDKIEEKNEEMPWCDQPEGSGCGEVFSNVLDYAAFLKCMMKKSGPISEEGHKELVAPRIITSPGEEPMPFMAHRLYALGWEIENFHGERTVGHDGAVTGFACKMLYIPRLNWGMVAFGNKDFANDAIDGIAWGLVDDLMGIPEEQRFDWDEDAQRIWDKYEPKTREQLFPKIPDPPIPLSRPLSEYAGVYNHPGFGDMVVELKDGKLQVDATDRTWRFMHYLDHVSGDFFFVDRVEVPSKETGTGKAQFRINADGRVIAFGMDLIAGMEDEKEPIWFERGDLHEGKDEGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQT2</accession>
    <name>A0A194XQT2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">LY89DRAFT_302569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076886.1">
        <property type="nucleotide sequence ID" value="XM_018206579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQT2"/>
    <dbReference type="GeneID" id="28816305"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_302569"/>
    <dbReference type="InParanoid" id="A0A194XQT2"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KUJ22531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="524" mass="59292" checksum="9489456412A8D956" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XQW0</accession>
    <name>A0A194XQW0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_547333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076923.1">
        <property type="nucleotide sequence ID" value="XM_018208261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XQW0"/>
    <dbReference type="GeneID" id="28817987"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_547333"/>
    <dbReference type="InParanoid" id="A0A194XQW0"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112986" checksum="9E0C3490F24C6127" modified="2016-10-05" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XRJ2</accession>
    <name>A0A194XRJ2_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">LY89DRAFT_606807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018076702.1">
        <property type="nucleotide sequence ID" value="XM_018210434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XRJ2"/>
    <dbReference type="GeneID" id="28820160"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_606807"/>
    <dbReference type="InParanoid" id="A0A194XRJ2"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="124"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KUJ22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="566" mass="62906" checksum="F40B37FF1A4E60FA" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS05</accession>
    <name>A0A194XS05_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_314228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947406">
        <property type="protein sequence ID" value="KUJ22926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077281.1">
        <property type="nucleotide sequence ID" value="XM_018206660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS05"/>
    <dbReference type="STRING" id="149040.A0A194XS05"/>
    <dbReference type="GeneID" id="28816386"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_314228"/>
    <dbReference type="InParanoid" id="A0A194XS05"/>
    <dbReference type="OrthoDB" id="5357734at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37576:SF2">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ22926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="623" mass="67514" checksum="462ED77B42AD3BEC" modified="2016-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XS36</accession>
    <name>A0A194XS36_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_167529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947405">
        <property type="protein sequence ID" value="KUJ23110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018077465.1">
        <property type="nucleotide sequence ID" value="XM_018205545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XS36"/>
    <dbReference type="GeneID" id="28815271"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_167529"/>
    <dbReference type="InParanoid" id="A0A194XS36"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="205" mass="22529" checksum="45A0B5848C78CFDD" modified="2016-10-05" version="1">MSLDARCSMLDTCTPTLGNALQPSTPTRAVPMAQQQLSRFGVQHRPEAGACTFIISGQRPLVLRRPAKHCLDLVRLVASLASCGYRRALILAFVYVHHLYAVPSDRRVERHSWNCRSKSGSRPRCLSSPCAAAQDFFSAGSFTTLGNTSRRTTQDLPSSMKKSFSLREALKGTQEQSRQGVQNGKVSWNMSRGTAAKQSPCTRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTU5</accession>
    <name>A0A194XTU5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_633430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078100.1">
        <property type="nucleotide sequence ID" value="XM_018211341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTU5"/>
    <dbReference type="STRING" id="149040.A0A194XTU5"/>
    <dbReference type="GeneID" id="28821067"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_633430"/>
    <dbReference type="InParanoid" id="A0A194XTU5"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="251" mass="26758" checksum="B7D0ED017F653F31" modified="2016-10-05" version="1">MSILVTDLKPHLALVTGASGGIGRATCLALANMGCSIAVHYHSSEDKAVTLVKELKSKGVRAEAFRADLTKYEEVRSLHKAVVDTLGPPTILFNNAGLTLKSGIKAITEISIDDFEHTWRANCGSAFLMTQLCLPDMEKKGWGRVIFCSSVAGFNGGVVGPHYASSKSALHGLIHWLAGAYSKTGVTVNGVAPALIQETTMLPGNNEELAKKIPIGRLGYPEEVAETVIWMVKTGYVTNKVIGVDGGFFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XTZ3</accession>
    <name>A0A194XTZ3_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_565569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078033.1">
        <property type="nucleotide sequence ID" value="XM_018208534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XTZ3"/>
    <dbReference type="GeneID" id="28818260"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_565569"/>
    <dbReference type="InParanoid" id="A0A194XTZ3"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="5">
        <location>
            <begin position="39"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ23678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="460" mass="51019" checksum="44B7A8EFADB33AF0" modified="2016-10-05" version="1" fragment="single">TRQLSSGPAPVRLSSFPGKDEAHRNVTIDVARQQQEMLGFGHSWTDSAVSLFETLEPSFFNMVMEDLFGQNGNNMAFMRHTVGSSDLSDTYYTYDDNGPVNQGKPDPGLLNFSLGAAGTRMADMIALMGDYKSDVTLCGSPWSAPGWMKKNGLLVADVHWSDDGTNNIANNSFDPAYADEFANYLARYIDAFQARGVNVNAISPMNEPLNSQGGYPCMYLGAEDEANLIVDALGSLMKERDVEIWAFDHNTDASFYPYQVLEKAQEYVQAVAWHCYALPAPDYSVLAEFRRRYPHIPQFMTECANYKPQAGTFNFQVAENFMLSIKNGASGATMWVMATDSYYGPHTPLAGCDGCLGSIIVHSPTLYTKTNDYYMIGQFSRFIRRGAISYATSDGGTAEDLSDKEQFYTIAAQNPDGSWVIVFMNNYGQEQNVVLQFTGQEEVFWQGVVPNATVVTWLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XU53</accession>
    <name>A0A194XU53_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_662643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078205.1">
        <property type="nucleotide sequence ID" value="XM_018212659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XU53"/>
    <dbReference type="GeneID" id="28822385"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_662643"/>
    <dbReference type="InParanoid" id="A0A194XU53"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ23850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="197" mass="22521" checksum="0387F22ADA7656E3" modified="2016-10-05" version="1">MASRTIVPSLLSPHERNNERTNQTKTLNGWNLRVRCATQSPLPEHVSPLKRAAVVNSMPEKYRTTFLAHNRKKKTLNYYDENGQIRWNYIEGVLKAKSSESDREAVGFSVRQSKFEHYHGVPDKRPPQISRTTKEKAAILKSHNQKWAAVRSHLTTGTEAASPAHEADKEATSTIHSHDRVMSEKEQKEYDKMWGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUD6</accession>
    <name>A0A194XUD6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_7451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078285.1">
        <property type="nucleotide sequence ID" value="XM_018221053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUD6"/>
    <dbReference type="GeneID" id="28830779"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_7451"/>
    <dbReference type="InParanoid" id="A0A194XUD6"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13824" checksum="327B594EC8D9E8CF" modified="2016-10-05" version="1">MPGGLNIIVEVIFVPIVVFCIIGFVIFKRKRKLERRRQIEQRNPFTKPWDPTAASTNLPPPQPVYGGFRAEATDFPPQYGYSQQGNYEAGKPWEQSVVNVQPYTPAQIGGYQQPYHQQSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XUL0</accession>
    <name>A0A194XUL0_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_727055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078360.1">
        <property type="nucleotide sequence ID" value="XM_018219115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XUL0"/>
    <dbReference type="GeneID" id="28828841"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_727055"/>
    <dbReference type="InParanoid" id="A0A194XUL0"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="199" mass="21809" checksum="7DA033720B112690" modified="2016-10-05" version="1">MSNIPLTTATTQSNPTRTWVVGVLSSRKTVVSEFVRLISEHENVFEIPVNGVGSDVNWVDWIVGGVGSWGTLQNVITAFSTNHLPLVICLREIGNISRHYIAGDRIIVSGYSRGAWAARYLAMLIDMIGLPKDGDEALFHRLYKACDNATILDESVAARLMEGYDCWQDVKINALCCFDTVGSFGLPLTGLAEPLAYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVB6</accession>
    <name>A0A194XVB6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_563843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078314.1">
        <property type="nucleotide sequence ID" value="XM_018208503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVB6"/>
    <dbReference type="FunCoup" id="A0A194XVB6">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XVB6"/>
    <dbReference type="GeneID" id="28818229"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_563843"/>
    <dbReference type="InParanoid" id="A0A194XVB6"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="116" mass="12784" checksum="198EC319F45A9A0E" modified="2016-10-05" version="1" fragment="single">FVPPIDVFSTEAAYILHIALPGAKKDDVGVNFDSDKGVLNIAGVVYRQGDEEFLKTLTQSERKVGAFDRSVKLPPANEEKEEIDGDAITAKLEDGILVVTVPKVEKEWTEVKRVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVK3</accession>
    <name>A0A194XVK3_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_604616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078516.1">
        <property type="nucleotide sequence ID" value="XM_018210366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVK3"/>
    <dbReference type="STRING" id="149040.A0A194XVK3"/>
    <dbReference type="GeneID" id="28820092"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_604616"/>
    <dbReference type="InParanoid" id="A0A194XVK3"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KUJ24161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="448" mass="49953" checksum="4AAC1C2F28C2AF90" modified="2016-10-05" version="1">MPLSGGQKDPFAGWAATLVDGLDTLYIMGLQEEFDNALKALDSIDFSTPKAERVPVFETTIRFLGGLLGAYDVSGPKYPIILQKADQLGEFLLRAFNTSTGIPVPYFWWGKQDDILQGENNVIIAQIGSLSLEFTRLAQLTGKRKYFDSISKITNHLDAAQNHTRIPGLWPSTIDTKGPSFPSASFTLGAFSDSLYEYLPKEHILLGGNTDQYLRMYRAALGPAAKYHFFQPKTPGNQDILFTGSLEARSEGPPSLNPDVQHLGCYAGGMVGLGARINNSPEELAMAIRLTNGCVWSYQNTASGIMPEIFSVEACQSPCEWTDENAVELGHQHGFTRVVDSSYQLHPEAIESVFVMYRITGDPIWQERGWKMFKVIVKHTRTAIANSRLQDVTNPVPPQEDSMESFWLAETLKYFFLLFSEPDVISLDDFVLNTEAHPFRQRDSSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XVN5</accession>
    <name>A0A194XVN5_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_679552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078750.1">
        <property type="nucleotide sequence ID" value="XM_018213890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XVN5"/>
    <dbReference type="STRING" id="149040.A0A194XVN5"/>
    <dbReference type="GeneID" id="28823616"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679552"/>
    <dbReference type="InParanoid" id="A0A194XVN5"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ24395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="508" mass="55490" checksum="CB64F1A8503C9FC7" modified="2016-10-05" version="1">MYAASIQSTTGTLAGYARKMTQNGRPDMEIILEDHNEGKTYTTFDPLSGRVEITAPHEARFDEIRITLEGTVKTFVENLSPHSTKARTTATHNFLRLSMPIRESDYPQPRIAEAGRTYTFPFNFVVPDQLLPRSCSHACVSDHVRDAHLRLPPSMGGRSFSGQDDLTPEMAKVNYAIKVKIVRTRERDGQEVVLVEGSKKIHIIPAIAEEPPMSVTHLDKDYVLSKTKSLKKGMFSGKLGKITVTAAQPNALVLPAPSASSTMVPGTTMTTVNLRFDPHDSSSQPPRLGGLTTKIKASTFYAARPAMEVPSHFGMVHQFESTRGVYDTSVPLSSRCVEAVTWTRHTPSPAYVRRNSASSTSSDDCSDEIHASPPKENKPYYTAEILLPITLPTSKAWIPTFHTCILSRSYTIDLSLTIHTPGTGVPASTVALHLPVQIAANGNNARRATLTAEEAAAELADADEFLRPRVLEMPSPELVGNSVINAGAELPPSYEDFAVPRRSVVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWR6</accession>
    <name>A0A194XWR6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF605-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">LY89DRAFT_679752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 120377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018079043.1">
        <property type="nucleotide sequence ID" value="XM_018213937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWR6"/>
    <dbReference type="STRING" id="149040.A0A194XWR6"/>
    <dbReference type="GeneID" id="28823663"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_679752"/>
    <dbReference type="InParanoid" id="A0A194XWR6"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KUJ24688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="458" mass="50383" checksum="70953AE76CDF670C" modified="2016-10-05" version="1">MAANIPAKLKAADLTRFIVRASQLEAVKPVVAYWCEYWIVNQILAKGLHNGDPETLQYTTTLMDKLELIKAENATNDAIVDDAAGQAYVEHFGLETFFRADRAVKANVVTKQTADTFQAAATFLELVNIWGTPDAETQSKIKYAKWNAVRIVRAIREGKDPNESNPKPDPVQEEVLPELDPNDPEVQQLEGPSKPQPASVEDVPDEQDKVEARIARQSSIDQSLHPSAEVSARGSPGNFEPYPRDGFPYTAVQDDNVSPLEPSPNERTGSVGGGYFPEVPTFTSQNQEPTLPTAPPDVLNLPQQPSAPPGFRAPEDFESFPPPTLPDDPPMPPQDFYRQSPPAQQPHVPPPQVTAYTPPVQQSPYQPPHQQPPPQFQPPPQQYQPPPQQYQPPPQRHIPAPAPAQAPAPIRKDQLITDDMSIAKAQKHARWAISALNFEDAETAVKELRAALQTLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWS4</accession>
    <name>A0A194XWS4_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_23335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078834.1">
        <property type="nucleotide sequence ID" value="XM_018206044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWS4"/>
    <dbReference type="GeneID" id="28815770"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_23335"/>
    <dbReference type="InParanoid" id="A0A194XWS4"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ24479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="288" mass="33324" checksum="899943F9835CE7CC" modified="2016-10-05" version="1">MYNVSIFPRRHASRGVFPPIIGRQDSRRRTRHYDEVSTKDHPAWICQSTLQTTIFHPSHSDRQQSSESNHQHSEPRALAGHVSKRTDRKVNALPPPPKRKINIQSNDKDSEEPEEKRDGHGDGDREDNTLLQGSGAEESDEEFESAEEDLSEEIWDEETRRQIQAEAQAELEKQNARAEARIFRPSQFLDGPGWITLESGSGYQLLAEDHKRVWRVTGPASGSYTRMIRINLVQLRNAGWIWDDVNRGWNRDFWKAQIFCTEVMEWKSFHRAYVGPPFCAQVFRSLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWT1</accession>
    <name>A0A194XWT1_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">LY89DRAFT_634614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078849.1">
        <property type="nucleotide sequence ID" value="XM_018211397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWT1"/>
    <dbReference type="FunCoup" id="A0A194XWT1">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="GeneID" id="28821123"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_634614"/>
    <dbReference type="InParanoid" id="A0A194XWT1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KUJ24494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="285" mass="31985" checksum="D000BA8B1D6D87F3" modified="2016-10-05" version="1">MASVPVSGVSSATVLLNNGVSMPKVHLGVYQSTNRTKNAVKWALQAGYRAIDCAETYGNEKEVGAAIISYLKANPELSRDEIWFTTKLRVNTSYDVTRSSLKGSIKRTKLGYVDLYLLHTPSGGREKRLECWRALEDALIEGEVRSIGVSNYGIKHLQELLDSKPRVIPAVNQIEVHPFNTHSNLTAFCQKHGIVVQAYSPLVQGRRMDHPTIVELSKKHKVSQAQILLRWGIQKGFVVLPKSTNQERIIANADIWEFEIEETDMERLDGLDEGLVTEWDLLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-10-05" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A194XWZ5</accession>
    <name>A0A194XWZ5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beclin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">LY89DRAFT_776667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947404">
        <property type="protein sequence ID" value="KUJ24584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018078939.1">
        <property type="nucleotide sequence ID" value="XM_018222063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A194XWZ5"/>
    <dbReference type="FunCoup" id="A0A194XWZ5">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="149040.A0A194XWZ5"/>
    <dbReference type="GeneID" id="28831789"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_776667"/>
    <dbReference type="InParanoid" id="A0A194XWZ5"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="157"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="288"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KUJ24584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="493" mass="54961" checksum="28C7D394491879A3" modified="2016-10-05" version="1">MPIYCQKCRTPLKLDSSLEDLNPAAFDLLVGATSQQYPKNTFSRPPYPEGRRKLYEQVSKNAGPPTIRRNLASGHRSDTAPPSLGNPAMSFVMLTESQVVPPSVVVKSPEDTNPGNNRHDKVVALDGQDEGKAMSQDMERASRLFEILSARSDIDHPVCTECTDMLVAGLQHRLEAATKERDAYVSFLKQVNAEIPTEEEVQESKDALAKARKEEEAAIEELKKLEAEKAAVDEEIAQLEEEARSLDIEEEKFWRDRNAFAMKLAEFQNIRDSVNLQYDHDTQLLEKLQRTNVYNDTFCISHDGKFGTINGLRLGRLSNVPVDWPEINAAWGHTVLLLQTVADRLGYKFQGYELQPMGSTSRIIRYETPNPSSSRNSPRAGKKHILELYSSGDMPLGLTFMHRRFDIAMEAFLECMRQLGAFVEAESAKSSESGRGLALPYKIDGAMIGDVSIKLGIAQDDAWSRACKFTLTCCKFLLAHASNVNAASGRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1G2</accession>
    <name>A0A132B1G2_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">LY89DRAFT_678950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947450">
        <property type="protein sequence ID" value="KUJ06222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060577.1">
        <property type="nucleotide sequence ID" value="XM_018213780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1G2"/>
    <dbReference type="STRING" id="149040.A0A132B1G2"/>
    <dbReference type="GeneID" id="28823506"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_678950"/>
    <dbReference type="InParanoid" id="A0A132B1G2"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="293"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KUJ06222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="526" mass="61563" checksum="7645CA6096440178" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1L5</accession>
    <name>A0A132B1L5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">LY89DRAFT_603462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947448">
        <property type="protein sequence ID" value="KUJ06290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060645.1">
        <property type="nucleotide sequence ID" value="XM_018210306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1L5"/>
    <dbReference type="GeneID" id="28820032"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603462"/>
    <dbReference type="InParanoid" id="A0A132B1L5"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KUJ06290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="558" mass="61425" checksum="73AF63E3863FC796" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B1S5</accession>
    <name>A0A132B1S5_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">LY89DRAFT_415683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947452">
        <property type="protein sequence ID" value="KUJ06183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060538.1">
        <property type="nucleotide sequence ID" value="XM_018207369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B1S5"/>
    <dbReference type="GeneID" id="28817095"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_415683"/>
    <dbReference type="InParanoid" id="A0A132B1S5"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KUJ06183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="54" mass="6077" checksum="3BDD68E4C16A46E5" modified="2016-05-11" version="1" fragment="single">MKTTKIIIHYSNSTIYYLLPLIGFPPHLPTSAHLLGILAIRSRICFKVILSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2F9</accession>
    <name>A0A132B2F9_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyribonuclease-like protein tatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">LY89DRAFT_603079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="350" mass="38723" checksum="7FFC96A7AE255D11" modified="2016-05-11" version="1">MATEYTIEAAASASQSSVPITNGVKKLYKPRYIDIGINLTDPVFTGLYYGTQRHPNDLSGVLQRAKEAGCEKLIVTGSDLKESRKAVQLAKEHPRVIYATIGVHPCNCSQFTKSPSPSTILDELRAMAVEAKASNHAVAFGEIGLDYDRLEHCPKEEQLKYFEAQLSLATEVQLPLFLHSRAAHADFIRILSSFSSRLPRKGVVHSFTGTKEEMWDLVEKGWDIGVNGCSMKTAENCEVVREVPLDRLQVETDGPWCEMRASHVSADFLLGMGVGPKAEEEEEEDQNGELKEWKSVKKERWAEGLMIKGRNEPCMIGHVAWAIAGIKGISVKQVSEAAWANSVRMFGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2L9</accession>
    <name>A0A132B2L9_MOLSC</name>
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        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">LY89DRAFT_790290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
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            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947444">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="psco:LY89DRAFT_790290"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="1"/>
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        </location>
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            <end position="644"/>
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        <location>
            <begin position="22"/>
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        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KUJ06636.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="644" mass="68875" checksum="19DB888A3A34DF98" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B2Z2</accession>
    <name>A0A132B2Z2_MOLSC</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">LY89DRAFT_662194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 120377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947447">
        <property type="protein sequence ID" value="KUJ06409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018212636.1"/>
    </dbReference>
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    <dbReference type="STRING" id="149040.A0A132B2Z2"/>
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    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abhydrolase_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="349"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KUJ06409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="592" mass="63283" checksum="AC2EA872FEFB48DE" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B3X7</accession>
    <name>A0A132B3X7_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_603110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947445">
        <property type="protein sequence ID" value="KUJ06624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018060979.1">
        <property type="nucleotide sequence ID" value="XM_018210287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B3X7"/>
    <dbReference type="STRING" id="149040.A0A132B3X7"/>
    <dbReference type="GeneID" id="28820013"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_603110"/>
    <dbReference type="InParanoid" id="A0A132B3X7"/>
    <dbReference type="OrthoDB" id="3554968at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ06624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="59" mass="6769" checksum="987488655D5CA46C" modified="2016-05-11" version="1">MLYTTYHKGQQQTGKFKDNIRFLPAPVGDLLLNYLVVVIPLLQVFLRRSAPHAIISPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B588</accession>
    <name>A0A132B588_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_358073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947439">
        <property type="protein sequence ID" value="KUJ07575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061930.1">
        <property type="nucleotide sequence ID" value="XM_018206977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B588"/>
    <dbReference type="GeneID" id="28816703"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_358073"/>
    <dbReference type="InParanoid" id="A0A132B588"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="89" mass="8289" checksum="ADF36F848CE837AD" modified="2016-05-11" version="1">MAGLLGNVTNTLDNTLTGGDKEQGQGGLLGSVGGTVNKTVDGAGNAVGQTTDGLGNTVGKTTEGVGNTAGGLTDTAGGAVGGATGQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B5U6</accession>
    <name>A0A132B5U6_MOLSC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">LY89DRAFT_742555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 120377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KQ947438">
        <property type="protein sequence ID" value="KUJ07785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018062140.1">
        <property type="nucleotide sequence ID" value="XM_018220839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B5U6"/>
    <dbReference type="STRING" id="149040.A0A132B5U6"/>
    <dbReference type="ESTHER" id="9helo-a0a132b5u6">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28830565"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_742555"/>
    <dbReference type="InParanoid" id="A0A132B5U6"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KUJ07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070700"/>
        </source>
    </evidence>
    <sequence length="578" mass="64942" checksum="F0DB661A3DEE717D" modified="2016-05-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-05-11" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A132B6S4</accession>
    <name>A0A132B6S4_MOLSC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">LY89DRAFT_660658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mollisia scopiformis</name>
        <name type="common">Conifer needle endophyte fungus</name>
        <name type="synonym">Phialocephala scopiformis</name>
        <dbReference type="NCBI Taxonomy" id="149040"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Mollisiaceae</taxon>
            <taxon>Mollisia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-10" db="EMBL/GenBank/DDBJ databases">
            <title>Full genome of DAOMC 229536 Phialocephala scopiformis, a fungal endophyte of spruce producing the potent anti-insectan compound rugulosin.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Walker A.K."/>
                <person name="Frasz S.L."/>
                <person name="Seifert K.A."/>
                <person name="Miller J.D."/>
                <person name="Mondo S.J."/>
                <person name="Labutti K."/>
                <person name="Lipzen A."/>
                <person name="Dockter R."/>
                <person name="Kennedy M."/>
                <person name="Grigoriev I.V."/>
                <person name="Spatafora J.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 120377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KQ947440">
        <property type="protein sequence ID" value="KUJ07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018061732.1">
        <property type="nucleotide sequence ID" value="XM_018212561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A132B6S4"/>
    <dbReference type="STRING" id="149040.A0A132B6S4"/>
    <dbReference type="GeneID" id="28822287"/>
    <dbReference type="KEGG" id="psco:LY89DRAFT_660658"/>
    <dbReference type="InParanoid" id="A0A132B6S4"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000070700">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>